Conjoint Professor

Professor David Goldstein

MBBS, FRACP, PRCP (UK)

Medicine & Health
School of Clinical Medicine

Prof Goldstein is a Conjoint Clinical Professor. He has been involved in a variety of clinical research projects ranging from laboratory basic science to novel therapeutics trials to psychosocial aspects of Cancer care. He has been PI of a number of NHMRC and Cancer Australia funded therapeutic trials including both investigator initiated and as Australian PI for multinational studies. He has also been involved with psychosocial and cross cultural/CALD research for many years. His clinical interests are treatment of GI malignancies including pancreas cancer, colorectal cancer, anal carcinoma, hepatobilary and upper GI malignancy and renal cell carcinoma and lymphoma.

Prof Goldstein has been a Chief or Principal Investigator on $39,000,000 peer reviewed funded grants. He was the Director of the UNSW Translational Cancer Research Network, a $6,000,000 5 year CINSW funded program now completed. He was the adult program leader of the UNSW National Cancer Survivors Centre and is involved with a research program associated with survivorship issues. As part of this activity, he was the Chief Investigator of a 5 year Cancer Institute NSW translational program grant of $3,100,000 to study the impact of chemotherapy induced peripheral neuropathy, now completed.

He also actively participates in two laboratory research programs dealing with stromal biology, pancreas drug resistance and modelling optimal targeted therapies.

Prof Goldstein has 370 co-authored peer reviewed publications, since 2017 citations 17460, overall 33917, H index 80, since 2017 56 [Google Scholar]. He has presented at numerous national and international meetings: ESMO- ESMO Asia, ESMO GI, USA – ASCO, Japan - Japan Pancreas Society, Gastro week and medical oncology group, New Zealand, S. Korea, Singapore, COSA ASM.

National and international collaborations with researchers at University of Sydney, MRC (UK), University of Liverpool, GERCOR, NCIC. Invited reviewer for leading scientific journals, and grant applications (NHMRC, ARC).

 

 

 

Phone
22577
Location
lowy cancer centre
  • Journal articles | 2022
    Livni L; Keating BA; Fiore NT; Lees JG; Goldstein D; Moalem-Taylor G, 2022, 'Effects of combined chemotherapy and anti-programmed cell death protein 1 treatment on peripheral neuropathy and neuroinflammation in mice', Pain, vol. 163, pp. 110 - 124, http://dx.doi.org/10.1097/j.pain.0000000000002384
    Journal articles | 2022
    Mahfouz FM; Park SB; Li T; Timmins HC; Horvath LG; Harrison M; Grimison P; King T; Goldstein D; Mizrahi D, 2022, 'Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients', Clinical Autonomic Research, http://dx.doi.org/10.1007/s10286-022-00895-w
    Journal articles | 2021
    Chiang JCB; Goldstein D; Trinh T; Au K; Mizrahi D; Muhlmann M; Crowe P; O’neill S; Edwards K; Park SB; Krishnan AV; Markoulli M, 2021, 'A cross-sectional study of sub-basal corneal nerve reduction following neurotoxic chemotherapy', Translational Vision Science and Technology, vol. 10, pp. 1 - 11, http://dx.doi.org/10.1167/tvst.10.1.24
    Journal articles | 2021
    Clifford BK; Jones MD; Simar D; Barry BK; Goldstein D, 2021, 'The effect of exercise intensity on exercise-induced hypoalgesia in cancer survivors: A randomized crossover trial', Physiological Reports, vol. 9, pp. e15047, http://dx.doi.org/10.14814/phy2.15047
    Journal articles | 2021
    Kokkinos J; Jensen A; Sharbeen G; McCarroll JA; Goldstein D; Haghighi KS; Phillips PA, 2021, 'Does the microenvironment hold the hidden key for functional precision medicine in pancreatic cancer?', Cancers, vol. 13, pp. 2427 - 2427, http://dx.doi.org/10.3390/cancers13102427
    Journal articles | 2021
    Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Timpson P; Pereira BA; Ritchie S; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2021, 'Ex vivo culture of intact human patient derived pancreatic tumour tissue', Scientific Reports, vol. 11, pp. 1944, http://dx.doi.org/10.1038/s41598-021-81299-0
    Journal articles | 2021
    Li T; Mizrahi D; Goldstein D; Kiernan MC; Park SB, 2021, 'Chemotherapy and peripheral neuropathy', Neurological Sciences, vol. 42, pp. 4109 - 4121, http://dx.doi.org/10.1007/s10072-021-05576-6
    Journal articles | 2021
    Mizrahi D; Park SB; Li T; Timmins HC; Trinh T; Au K; Battaglini E; Wyld D; Henderson RD; Grimison P; Ke H; Geelan-Small P; Marker J; Wall B; Goldstein D, 2021, 'Hemoglobin, Body Mass Index, and Age as Risk Factors for Paclitaxel- and Oxaliplatin-Induced Peripheral Neuropathy', JAMA network open, vol. 4, pp. e2036695, http://dx.doi.org/10.1001/jamanetworkopen.2020.36695
    Journal articles | 2021
    Oar A; Lee M; Le H; Wilson K; Aiken C; Chantrill L; Simes J; Nguyen N; Barbour A; Samra J; Sjoquist KM; Moore A; Espinoza D; Gebski V; Yip S; Chu J; Kneebone A; Goldstein D, 2021, 'AGITG MASTERPLAN: a randomised phase II study of modified FOLFIRINOX alone or in combination with stereotactic body radiotherapy for patients with high-risk and locally advanced pancreatic cancer', BMC Cancer, vol. 21, http://dx.doi.org/10.1186/s12885-021-08666-y
    Journal articles | 2021
    Timmins HC; Mizrahi D; Li T; Kiernan MC; Goldstein D; Park SB, 2021, 'Metabolic and lifestyle risk factors for chemotherapy-induced peripheral neuropathy in taxane and platinum-treated patients: a systematic review', Journal of Cancer Survivorship, http://dx.doi.org/10.1007/s11764-021-00988-x
    Journal articles | 2021
    Trinh T; Park SB; Murray J; Pickering H; Lin CSY; Martin A; Friedlander M; Kiernan MC; Goldstein D; Krishnan AV, 2021, 'Neu-horizons: neuroprotection and therapeutic use of riluzole for the prevention of oxaliplatin-induced neuropathy—a randomised controlled trial', Supportive Care in Cancer, vol. 29, pp. 1103 - 1110, http://dx.doi.org/10.1007/s00520-020-05591-x
    Journal articles | 2020
    Barbour AP; Samra JS; Haghighi KS; Donoghoe MW; Burge M; Harris MT; Chua YJ; Mitchell J; O’Rourke N; Chan H; Gebski VJ; Gananadha S; Croagh DG; Kench JG; Goldstein D; Barbour A; Goldstein D; Samra JS; Harris M; Chua YJ; Yip S; Simes J; Hicks R; Coates A; Gurney H; Do V; Marschner I; Goldstone S; Yip S; Pavlakis N; Goldstein D; Aghmesheh M; Joubert W; Grimes D; Burge M; Bagia S; Jaber M; Bryant R; Nathanson L; Cavallucci D; Fawcett J; O’Rourke T; Jones R, 2020, 'The AGITG GAP Study: A Phase II Study of Perioperative Gemcitabine and Nab-Paclitaxel for Resectable Pancreas Cancer', Annals of Surgical Oncology, vol. 27, pp. 2506 - 2515, http://dx.doi.org/10.1245/s10434-020-08205-2
    Journal articles | 2020
    Butow P; Butow P; Davies G; Napier CE; Schlub T; Best MC; Bartley N; Juraskova I; Meiser B; Ballinger ML; Biesecker B; Goldstein D; Thomas DM, 2020, 'Assessment of the Value of Tumor Variation Profiling Perceived by Patients with Cancer', JAMA Network Open, vol. 3, pp. e204721, http://dx.doi.org/10.1001/jamanetworkopen.2020.4721
    Journal articles | 2020
    Gronchi A; Bonvalot S; Poveda Velasco A; Kotasek D; Rutkowski P; Hohenberger P; Fumagalli E; Judson IR; Italiano A; Gelderblom HJ; Van Coevorden F; Penel N; Kopp HG; Duffaud F; Goldstein D; Broto JM; Wardelmann E; Marréaud S; Smithers M; Le Cesne A; Zaffaroni F; Litière S; Blay JY; Casali PG, 2020, 'Quality of surgery and outcome in localized gastrointestinal stromal tumors treated within an international intergroup randomized clinical trial of adjuvant imatinib', JAMA Surgery, vol. 155, pp. e200397, http://dx.doi.org/10.1001/jamasurg.2020.0397
    Journal articles | 2020
    Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, vol. 240, pp. 119742, http://dx.doi.org/10.1016/j.biomaterials.2019.119742
    Journal articles | 2020
    Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Bringing the pancreas patient back to the bench: Ex vivo culture of intact human patient derived pancreatic tumour tissue', , http://dx.doi.org/10.1101/2020.07.30.223925
    Journal articles | 2020
    Lees JG; White D; Keating BA; Barkl-Luke ME; Makker PGS; Goldstein D; Moalem-Taylor G, 2020, 'Oxaliplatin-induced haematological toxicity and splenomegaly in mice', PLoS ONE, vol. 15, pp. e0238164, http://dx.doi.org/10.1371/journal.pone.0238164
    Journal articles | 2020
    Lim BT; Butow P; Sze ML; Girgis A; Jefford M; Goldstein D; Costa D, 2020, 'Impact of migrancy on cancer clinical trial participation: Factors associated with approach and consent in Australian-born versus migrant groups', Asia-Pacific Journal of Clinical Oncology, vol. 16, pp. 115 - 122, http://dx.doi.org/10.1111/ajco.13290
    Journal articles | 2020
    Makker PGS; White D; Lees JG; Parmar J; Goldstein D; Park SB; Howells J; Moalem-Taylor G, 2020, 'Acute changes in nerve excitability following oxaliplatin treatment in mice', Journal of Neurophysiology, vol. 124, pp. 232 - 244, http://dx.doi.org/10.1152/jn.00260.2020
    Journal articles | 2020
    McNamara MG; Lopes A; Wasan H; Malka D; Goldstein D; Shannon J; Okusaka T; Knox JJ; Wagner AD; André T; Cunningham D; Moehler M; Jensen LH; Koeberle D; Bekaii-Saab T; Bridgewater J; Valle JW, 2020, 'Landmark survival analysis and impact of anatomic site of origin in prospective clinical trials of biliary tract cancer', Journal of Hepatology, vol. 73, pp. 1109 - 1117, http://dx.doi.org/10.1016/j.jhep.2020.05.014
    Journal articles | 2020
    Pothula SP; Xu Z; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Targeting hgf/c-met axis in pancreatic cancer', International Journal of Molecular Sciences, vol. 21, pp. 1 - 18, http://dx.doi.org/10.3390/ijms21239170
    Journal articles | 2020
    Reni M; Riess H; O'Reilly EM; Reeves JA; Chiorean E; George TJ; Scheithauer W; Pascal A; Lerch M; Brenner WS; Ko Y-J; Tabernero J; Van Cutsem E; Philip PA; Goldstein D; Berlin J; Biankin A; Tempero MA, 2020, 'Concordance between independent and investigator assessment of disease-free survival (DFS) in the APACT trial.', Journal of Clinical Oncology, vol. 38, pp. 4618 - 4618, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.4618
    Journal articles | 2020
    Timmins HC; Li T; Kiernan MC; Baron-Hay S; Marx G; Boyle F; Goldstein D; Park SB, 2020, 'Taxane-induced peripheral neuropathy: differences in patient report and objective assessment', Supportive Care in Cancer, vol. 28, pp. 4459 - 4466, http://dx.doi.org/10.1007/s00520-020-05299-y
    Journal articles | 2020
    Tran B; Vajdic CM; Webber K; Laaksonen MA; Stavrou EP; Tiller K; Suchy S; Bosco AM; Harris MF; Lloyd AR; Goldstein D, 2020, 'Self-reported health, lifestyle and social circumstances of Australian adult cancer survivors: A propensity score weighted cross-sectional study', Cancer Epidemiology, vol. 67, pp. 101773 - 101773, http://dx.doi.org/10.1016/j.canep.2020.101773
    Journal articles | 2019
    Lim BT; Butow P; Mills J; Miller A; Pearce A; Goldstein D, 2019, 'Challenges and perceived unmet needs of Chinese migrants affected by cancer: Focus group findings', Journal of Psychosocial Oncology, vol. 37, pp. 383 - 397, http://dx.doi.org/10.1080/07347332.2018.1551261
    Journal articles | 2019
    Livni L; Lees JG; Barkl-Luke ME; Goldstein D; Moalem-Taylor G, 2019, 'Dorsal root ganglion explants derived from chemotherapy-treated mice have reduced neurite outgrowth in culture', Neuroscience Letters, vol. 694, pp. 14 - 19, http://dx.doi.org/10.1016/j.neulet.2018.11.016
    Journal articles | 2019
    McCrary JM; Goldstein D; Sandler CX; Barry BK; Marthick M; Timmins HC; Li T; Horvath L; Grimison P; Park SB, 2019, 'Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy', Supportive Care in Cancer, vol. 27, pp. 3849 - 3857, http://dx.doi.org/10.1007/s00520-019-04680-w
    Journal articles | 2019
    McCrary JM; Goldstein D; Wyld D; Henderson R; Lewis CR; Park SB, 2019, 'Mobility in survivors with chemotherapy-induced peripheral neuropathy and utility of the 6-min walk test', Journal of Cancer Survivorship, vol. 13, pp. 495 - 502, http://dx.doi.org/10.1007/s11764-019-00769-7
    Journal articles | 2019
    Tan AC; McCrary JM; Park SB; Trinh T; Goldstein D, 2019, 'Chemotherapy-induced peripheral neuropathy—patient-reported outcomes compared with NCI-CTCAE grade', Supportive Care in Cancer, vol. 27, pp. 4771 - 4777, http://dx.doi.org/10.1007/s00520-019-04781-6
    Journal articles | 2019
    Tempero MA; Reni M; Riess H; O’Reilly EM; Krishnamurthi S; Österlund P; Ales-Diaz IC; Milella M; Siena S; Tabernero J; Van Cutsem E; Philip PA; Goldstein D; Berlin JD; Li M; Ferrara S; Bruchec YL; McGovern D; Biankin A, 2019, 'Phase III, international, multicenter, randomized, open-label trial of adjuvant nab-paclitaxel plus gemcitabine (nab-P/G) vs gemcitabine (G) alone for surgically resected pancreatic adenocarcinoma (APACT): Subgroup analyses', Annals of Oncology, vol. 30, pp. v259 - v260, http://dx.doi.org/10.1093/annonc/mdz247.010
    Journal articles | 2019
    Tempero MA; Reni M; Riess H; Pelzer U; O'Reilly EM; Winter JM; Oh D-Y; Li C-P; Tortora G; Chang H-M; Lopez CD; Tabernero J; Van Cutsem E; Philip PA; Goldstein D; Berlin J; Ferrara S; Li M; Lu BD; Biankin A, 2019, 'APACT: phase III, multicenter, international, open-label, randomized trial of adjuvant nab-paclitaxel plus gemcitabine (nab-P/G) vs gemcitabine (G) for surgically resected pancreatic adenocarcinoma.', Journal of Clinical Oncology, vol. 37, pp. 4000 - 4000, http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4000
    Journal articles | 2018
    Clifford BK; Mizrahi D; Sandler CX; Barry BK; Simar D; Wakefield CE; Goldstein D, 2018, 'Barriers and facilitators of exercise experienced by cancer survivors: a mixed methods systematic review', Supportive Care in Cancer, vol. 26, pp. 685 - 700, http://dx.doi.org/10.1007/s00520-017-3964-5
    Journal articles | 2018
    Dumbrava MI; Burmeister EA; Wyld D; Goldstein D; O'Connell DL; Beesley VL; Gooden HM; Janda M; Jordan SJ; Merrett ND; Payne ME; Waterhouse MA; Neale RE, 2018, 'Chemotherapy in patients with unresected pancreatic cancer in Australia: A population-based study of uptake and survival', Asia-Pacific Journal of Clinical Oncology, vol. 14, pp. 326 - 336, http://dx.doi.org/10.1111/ajco.12862
    Journal articles | 2018
    Elander NO; Aughton K; Ghaneh P; Neoptolemos JP; Palmer DH; Cox TF; Campbell F; Costello E; Halloran CM; Mackey JR; Scarfe AG; Valle JW; McDonald AC; Carter R; Tebbutt NC; Goldstein D; Shannon J; Dervenis C; Glimelius B; Deakin M; Charnley RM; Anthoney A; Lerch MM; Mayerle J; Oláh A; Büchler MW; Greenhalf W, 2018, 'Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer', British Journal of Cancer, vol. 118, pp. 947 - 954, http://dx.doi.org/10.1038/s41416-018-0004-2
    Journal articles | 2018
    Elander NO; Aughton K; Ghaneh P; Neoptolemos JP; Palmer DH; Cox TF; Campbell F; Costello E; Halloran CM; Mackey JR; Scarfe AG; Valle JW; McDonald AC; Carter R; Tebbutt NC; Goldstein D; Shannon J; Dervenis C; Glimelius B; Deakin M; Charnley RM; Anthoney A; Lerch MM; Mayerle J; Oláh A; Büchler MW; Greenhalf W, 2018, 'Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy', British Journal of Cancer, vol. 118, pp. 1084 - 1088, http://dx.doi.org/10.1038/s41416-018-0005-1
    Journal articles | 2018
    Feather CE; Lees JG; Makker PGS; Goldstein D; Kwok JB; Moalem-Taylor G; Polly P, 2018, 'Oxaliplatin induces muscle loss and muscle-specific molecular changes in Mice', Muscle and Nerve, vol. 57, pp. 650 - 658, http://dx.doi.org/10.1002/mus.25966
    Journal articles | 2018
    Martin AJ; Gibbs E; Sjoquist K; Pavlakis N; Simes J; Price T; Shannon J; Gill S; Jain V; Liu G; Kannourakis G; Kim YH; Kim JW; Goldstein D, 2018, 'Health-related quality of life associated with regorafenib treatment in refractory advanced gastric adenocarcinoma', Gastric Cancer, vol. 21, pp. 473 - 480, http://dx.doi.org/10.1007/s10120-017-0754-1
    Journal articles | 2018
    Tie J; Cohen JD; Wang Y; Li L; Christie M; Simons K; Elsaleh H; Kosmider S; Wong R; Yip D; Lee M; Tran B; Rangiah D; Burge M; Goldstein D; Singh M; Skinner I; Faragher I; Croxford M; Bampton C; Haydon A; Jones IT; S Karapetis C; Price T; Schaefer MJ; Ptak J; Dobbyn L; Silliman N; Kinde I; Tomasetti C; Papadopoulos N; Kinzler K; Volgestein B; Gibbs P, 2018, 'Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: A prospective biomarker study', Gut, vol. 68, pp. 663 - 671, http://dx.doi.org/10.1136/gutjnl-2017-315852
    Journal articles | 2018
    Wang X; Goldstein D; Crowe PJ; Yang JL, 2018, 'Antitumour effects and mechanisms of action of the panHER inhibitor, dacomitinib, alone and in combination with the STAT3 inhibitor, S3I-201, in human sarcoma cell lines', International Journal of Oncology, vol. 52, pp. 2143 - 2154, http://dx.doi.org/10.3892/ijo.2018.4337
    Journal articles | 2018
    ter Veer E; van Rijssen LB; Besselink MG; Mali RMA; Berlin JD; Boeck S; Bonnetain F; Chau I; Conroy T; Van Cutsem E; Deplanque G; Friess H; Glimelius B; Goldstein D; Herrmann R; Labianca R; Van Laethem JL; Macarulla T; van der Meer JHM; Neoptolemos JP; Okusaka T; O'Reilly EM; Pelzer U; Philip PA; van der Poel MJ; Reni M; Scheithauer W; Siveke JT; Verslype C; Busch OR; Wilmink JW; van Oijen MGH; van Laarhoven HWM, 2018, 'Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease', The Lancet Oncology, vol. 19, pp. e151 - e160, http://dx.doi.org/10.1016/S1470-2045(18)30098-6
    Journal articles | 2017
    Kandula T; Farrar MA; Kiernan MC; Krishnan AV; Goldstein D; Horvath L; Grimison P; Boyle F; Baron-Hay S; Park SB, 2017, 'Neurophysiological and clinical outcomes in chemotherapy-induced neuropathy in cancer', Clinical Neurophysiology, vol. 128, pp. 1166 - 1175, http://dx.doi.org/10.1016/j.clinph.2017.04.009
    Journal articles | 2017
    Lees JG; Makker PGS; Tonkin RS; Abdulla M; Park SB; Goldstein D; Moalem-Taylor G, 2017, 'Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy', European Journal of Cancer, vol. 73, pp. 22 - 29, http://dx.doi.org/10.1016/j.ejca.2016.12.006
    Journal articles | 2017
    Makker PGS; Duffy SS; Lees JG; Perera CJ; Tonkin RS; Butovsky O; Park SB; Goldstein D; Moalem-Taylor G, 2017, 'Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0170814
    Journal articles | 2017
    McCrary JM; Goldstein D; Boyle F; Cox K; Grimison P; Kiernan MC; Krishnan AV; Lewis CR; Webber K; Baron-Hay S; Horvath L; Park SB, 2017, 'Optimal clinical assessment strategies for chemotherapy-induced peripheral neuropathy (CIPN): a systematic review and Delphi survey', Supportive Care in Cancer, vol. 25, pp. 3485 - 3493, http://dx.doi.org/10.1007/s00520-017-3772-y
    Journal articles | 2017
    Pang TCY; Xu Z; Pothula S; Becker T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2017, 'Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research', Carcinogenesis, vol. 38, pp. 588 - 591, http://dx.doi.org/10.1093/carcin/bgx030
    Journal articles | 2017
    Sandler CX; Goldstein D; Horsfield S; Bennett BK; Friedlander M; Bastick PA; Lewis CR; segelov E; Boyle FM; Chin MT; webber K; Barry BK; Lloyd AR, 2017, 'Randomized evaluation of cognitive-behavioral therapy and graded exercise therapy for post-cancer fatigue.', Journal of Pain and Symptom Management, vol. 54, pp. 74 - 84, http://dx.doi.org/10.1016/j.jpainsymman.2017.03.015
    Journal articles | 2017
    Segelov E; Lordick F; Goldstein D; Chantrill LA; Croagh D; Lawrence B; Arnold D; Chau I; Obermannova R; Price TJ, 2017, 'Current challenges in optimizing systemic therapy for patients with pancreatic cancer: expert perspectives from the Australasian Gastrointestinal Trials Group (AGITG) with invited international faculty', Expert Review of Anticancer Therapy, vol. 17, pp. 951 - 964, http://dx.doi.org/10.1080/14737140.2017.1369882
    Journal articles | 2017
    Sharbeen G; Youkhana J; Mawson A; McCarroll J; Nunez A; Biankin A; Johns A; Goldstein D; Phillips P, 2017, 'MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity', Oncotarget, vol. 8, pp. 9216 - 9229, http://dx.doi.org/10.18632/oncotarget.13985
    Journal articles | 2017
    Yang JL; Gupta RD; Goldstein D; Crowe PJ, 2017, 'Significance of phosphorylated epidermal growth factor receptor and its signal transducers in human soft tissue sarcoma', International Journal of Molecular Sciences, vol. 18, http://dx.doi.org/10.3390/ijms18061159
    Journal articles | 2016
    Burmeister EA; Waterhouse M; Jordan SJ; O'Connell DL; Merrett ND; Goldstein D; Wyld D; Beesley V; Gooden H; Janda M; Neale RE, 2016, 'Determinants of survival and attempted resection in patients with non-metastatic pancreatic cancer: An Australian population-based study', Pancreatology, vol. 16, pp. 873 - 881, http://dx.doi.org/10.1016/j.pan.2016.06.010
    Journal articles | 2016
    Gandy RC; Barbour AP; Samra J; Nikfarjam M; Haghighi K; Kench JG; Saxena P; Goldstein D, 2016, 'Refining the care of patients with pancreatic cancer: The AGITG Pancreatic Cancer Workshop consensus', Medical Journal of Australia, vol. 204, pp. 419 - 422.e1, http://dx.doi.org/10.5694/mja16.00061
    Journal articles | 2016
    Kandula T; Park SB; Cohn RJ; Krishnan AV; Farrar MA, 2016, 'Pediatric chemotherapy induced peripheral neuropathy: A systematic review of current knowledge', Cancer Treatment Reviews, vol. 50, pp. 118 - 128, http://dx.doi.org/10.1016/j.ctrv.2016.09.005
    Journal articles | 2016
    Sharbeen G; McCarroll J; Liu J; Youkhana J; Limbri LF; Biankin AV; Johns A; Kavallaris M; Goldstein D; Phillips PA, 2016, 'Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids', Neoplasia (United States), vol. 18, pp. 753 - 764, http://dx.doi.org/10.1016/j.neo.2016.10.011
    Journal articles | 2016
    Vickers MM; Lee C; Tu D; Wheatley-Price P; Parulekar W; Brundage MD; Moore MJ; Au H; O'Callaghan CJ; Jonker DJ; Ringash J; Goldstein D, 2016, 'Significance of baseline and change in quality of life scores in predicting clinical outcomes in an international phase III trial of advanced pancreatic cancer: NCIC CTG PA.3', Pancreatology, vol. 16, pp. 1106 - 1112, http://dx.doi.org/10.1016/j.pan.2016.08.013
    Journal articles | 2016
    Wang X; Goldstein D; Crowe PJ; Yang JL, 2016, 'Next-generation EGFR/HER tyrosine kinase inhibitors for the treatment of patients with non-small-cell lung cancer harboring EGFR mutations: A review of the evidence', OncoTargets and Therapy, vol. 9, pp. 5461 - 5473, http://dx.doi.org/10.2147/OTT.S94745
    Journal articles | 2015
    Apte MV; Xu Z; Pothula S; Goldstein D; Pirola RC; Wilson JS, 2015, 'Pancreatic cancer: The microenvironment needs attention too!', Pancreatology, vol. 15, pp. S32 - S38, http://dx.doi.org/10.1016/j.pan.2015.02.013
    Journal articles | 2015
    Jaeger U; Trneny M; Melzer H; Praxmarer M; Nawarawong W; Yehuda DB; Goldstein D; Mihaljevic B; Ilhan O; Ballova V; Hedenus M; Hsiao LT; Au WY; Burgstaller S; Weidinger G; Keil F; Dittrich C; Skrabs C; Klingler A; Chott A; Fridrik MA; Greil R, 2015, 'Rituximab maintenance for patients with aggressive B-cell lymphoma in first remission: Results of the randomized NHL13 trial', Haematologica, vol. 100, pp. 955 - 963, http://dx.doi.org/10.3324/haematol.2015.125344
    Journal articles | 2015
    McCarroll JA; Sharbeen G; Liu J; Youkhana J; Goldstein D; McCarthy N; Limbri LF; Dischl D; Ceyhan GO; Erkan M; Johns AL; Biankin AV; Kavallaris M; Phillips PA, 2015, 'βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer', Oncotarget, vol. 6, pp. 2235 - 2249, http://dx.doi.org/10.18632/oncotarget.2946
    Journal articles | 2015
    Sharbeen G; McCarroll J; Goldstein D; Phillips PA, 2015, 'Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer', Frontiers in Nutrition, vol. 2, pp. 10, http://dx.doi.org/10.3389/fnut.2015.00010
    Journal articles | 2015
    Sze M; Butow P; Bell M; Vaccaro L; Dong S; Eisenbruch M; Jefford M; Girgis A; King M; McGrane J; Ng W; Asghari R; Parente P; Liauw W; Goldstein D; Psycho-oncology Co-operative Research Group Culturally and Linguistically Diverse (CALD) TEAM , 2015, 'Migrant health in cancer: outcome disparities and the determinant role of migrant-specific variables', Oncologist, vol. 20, pp. 523 - 531, http://dx.doi.org/10.1634/theoncologist.2014-0274
    Journal articles | 2015
    Vajdic CM; Goldstein D, 2015, 'Cancer of unknown primary site', Australian Family Physician, vol. 44, pp. 640 - 643
    Journal articles | 2015
    Wang X; Batty KM; Crowe PJ; Goldstein D; Yang JL, 2015, 'The Potential of panHER Inhibition in Cancer', Frontiers in Oncology, vol. 5, http://dx.doi.org/10.3389/fonc.2015.00002
    Journal articles | 2014
    Bennett BK; Goldstein D; Chen M; Davenport TA; Vollmer-Conna U; Scott EM; Hickie IB; Lloyd AR, 2014, 'Characterization of fatigue states in medicine and psychiatry by structured interview', Psychosomatic Medicine, vol. 76, pp. 379 - 388, http://dx.doi.org/10.1097/PSY.0000000000000061
    Journal articles | 2014
    Goldstein D; Bell ML; Butow P; Sze M; Vaccaro L; Dong S; Liauw W; Hui R; Tattersall M; Ng W; Asghari R; Steer C; Vardy J; Parente P; Harris M; Karanth NV; King M; Girgis A; Eisenbruch M; Jefford M, 2014, 'Immigrants' perceptions of the quality of their cancer care: An Australian comparative study, identifying potentially modifiable factors', Annals of Oncology, vol. 25, pp. 1643 - 1649, http://dx.doi.org/10.1093/annonc/mdu182
    Journal articles | 2014
    McCarroll J; Teo J; Boyer C; Goldstein D; Kavallaris M; Phillips PA, 2014, 'Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer', Frontiers in Physiology, vol. 5, pp. 1 - 10, http://dx.doi.org/10.3389/fphys.2014.00002
    Journal articles | 2014
    McCarroll JA; Naim S; Sharbeen G; Russia N; Lee J; Kavallaris M; Goldstein D; Phillips PA, 2014, 'Role of pancreatic stellate cells in chemoresistance in pancreatic cancer', Frontiers in Physiology, vol. 5 APR, http://dx.doi.org/10.3389/fphys.2014.00141
    Journal articles | 2014
    Park SB; Kwok JB; Loy CT; Friedlander ML; Lin CSY; Krishnan AV; Lewis CR; Kiernan MC, 2014, 'Paclitaxel-induced neuropathy: Potential association of MAPT and GSK3B genotypes', BMC Cancer, vol. 14, http://dx.doi.org/10.1186/1471-2407-14-993
    Journal articles | 2014
    Patel MB; Pothula SP; Xu Z; Lee AK; Goldstein D; Pirola RC; Apte MV; Wilson JS, 2014, 'The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: Anti-angiogenic implications in pancreatic cancer', Carcinogenesis, vol. 35, http://dx.doi.org/10.1093/carcin/bgu122
    Journal articles | 2014
    Tempero MA; Cardin DB; Biankin A; Goldstein D; Moore M; O'Reilly EM; Philip PA; Riess H; Macarulla T; Yung L; Wei X; Lu B, 2014, 'APACT: A phase 3 randomized, open-label, multicenter trial evaluating the use of adjuvant nab-paclitaxel (nab-P) plus gemcitabine (G) versus G alone in patients (pts) with surgically resected ductal pancreatic adenocarcinoma (PDA).', Journal of Clinical Oncology, vol. 32, pp. TPS4162 - TPS4162, http://dx.doi.org/10.1200/jco.2014.32.15_suppl.tps4162
    Journal articles | 2013
    Butow PN; Aldridge L; Bell M; Sze M; Eisenbruch M; Jefford M; Schofield P; Girgis A; King M; Duggal-beri P; Goldstein D, 2013, 'Inferior health-related quality of life and psychological well-being in immigrant cancer survivors: A population-based study', European Journal of Cancer, vol. 49, pp. 1948 - 1956, http://dx.doi.org/10.1016/j.ejca.2013.01.011
    Journal articles | 2013
    Butow PN; Bell M; Aldridge L; Sze M; Eisenbruch M; Jefford M; Schofield P; Girgis A; King M; Duggal-beri P; McGrane J, 2013, 'Unmet needs in immigrant cancer survivors: a cross-sectional population-based study', Supportive Care in Cancer, vol. 21, pp. 2509 - 2520, http://dx.doi.org/10.1007/s00520-013-1819-2
    Journal articles | 2013
    Park SB; Goldstein D; Krishnan AV; Lin CSY; Friedlander ML; Cassidy J; Koltzenburg M; Kiernan MC, 2013, 'Chemotherapy-induced peripheral neurotoxicity: A critical analysis', CA Cancer Journal for Clinicians, vol. 63, pp. 419 - 437, http://dx.doi.org/10.3322/caac.21204
    Journal articles | 2013
    Tan CJ; Yang JL; Crowe P; Goldstein D, 2013, 'Targeted therapy in soft tissue sarcoma-A novel direction in therapeutics', Chinese Clinical Oncology, vol. 2, http://dx.doi.org/10.3978/j.issn.2304-3865.2013.08.01
    Journal articles | 2013
    Tan K; Goldstein D; Crowe P; Yang JL, 2013, 'Uncovering a key to the process of metastasis in human cancers: A review of critical regulators of anoikis', Journal of Cancer Research and Clinical Oncology, vol. 139, pp. 1795 - 1805, http://dx.doi.org/10.1007/s00432-013-1482-5
    Journal articles | 2013
    Teo J; Erlich RB; Sagnella S; Dwarte T; Davis TP; Kavallaris M; McCarroll J; Boyer C; Duong HTT; Phillips P; Sharbeen G; Goldstein D, 2013, 'Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers', Molecular Pharmaceutics, vol. 10, pp. 2435 - 2444, http://dx.doi.org/10.1021/mp400049e
    Journal articles | 2013
    Von Hoff DD; Ervin T; Arena FP; Chiorean EG; Infante J; Moore M; Seay T; Tjulandin SA; Ma WW; Saleh MN; Harris M; Reni M; Dowden S; Laheru D; Bahary N; Ramanathan RK; Tabernero J; Hidalgo M; Goldstein D; Van Cutsem E; Wei X; Iglesias J; Renschler MF, 2013, 'Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine', New England Journal of Medicine, vol. 369, pp. 1691 - 1703, http://dx.doi.org/10.1056/NEJMoa1304369
    Journal articles | 2013
    Webber K; Girgis A; Bennett BK; Bonaventura A; Boyle FM; Koh E-S; Friedlander M; Segelov E; Goldstein D, 2013, 'The unmet needs of cancer survivors and their preferences for discussing them with oncologists and general practitioners (GPs).', Journal of Clinical Oncology, vol. 31, pp. 9602 - 9602, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.9602
    Journal articles | 2012
    Butow P; Lobb EA; Jefford M; Goldstein D; Eisenbruch M; Girgis A; King MT; Sze M; Aldridge L; Schofield P, 2012, 'A bridge between cultures: Interpreters' perspectives of consultations with migrant oncology patients', Supportive Care in Cancer, vol. 20, pp. 235 - 244, http://dx.doi.org/10.1007/s00520-010-1046-z
    Journal articles | 2012
    Demetri GD; Garrett C; Sch offski P; Shah M; Verweij J; Leyvraz S; Hurwitz HI; Lopez Pousa A; Le Cesne A; Goldstein D; Paz-Ares L; Blay J; McArthur G; Xu Q; Huang X; Harmon CS; Tassell V; Cohen DP; Casali P, 2012, 'Complete Longitudinal Analyses of the Randomized,Placebo-Controlled, Phase III Trial of Sunitinib in Patients with Gastrointestinal Stromal Tumor following Imatinib Failure', Clinical Cancer Research, vol. 18, pp. 3170 - 3179, http://dx.doi.org/10.1158/1078-0432.CCR-11-3005
    Journal articles | 2012
    Wang X; Crowe PJ; Goldstein D; Yang JL, 2012, 'STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers', International Journal of Oncology, vol. 41, pp. 1181 - 1191, http://dx.doi.org/10.3892/ijo.2012.1568
    Journal articles | 2011
    Luckett T; Goldstein D; Butow PN; Gebski V; Aldridge L; McGrane J; Ng W; King MT, 2011, 'Psychological morbidity and quality of life of ethnic minority patients with cancer: a systematic review and meta-analysis', Lancet Oncology, vol. 12, pp. 1240 - 1248, http://dx.doi.org/10.1016/S1470
    Journal articles | 2011
    Park SB; Lin CS-Y; Krishnan AV; Goldstein D; Friedlander M; Kiernan MC, 2011, 'Long-term neuropathy after Oxaliplatin treatment: Challenging the dictum of reversibility', Oncologist, vol. 16, pp. 708 - 716, http://dx.doi.org/10.1634/theoncologist.2010-0248
    Journal articles | 2011
    Park SB; Lin CS-Y; Krishnan AV; Goldstein D; Friedlander M; Kiernan MC, 2011, 'Utilizing natural activity to dissect the pathophysiology of acute oxaliplatin-induced neuropathy', Experimental Neurology, vol. 227, pp. 120 - 127, http://dx.doi.org/10.1016/j.expneurol.2010.10.002
    Journal articles | 2010
    Goldstein D; Butow PN; Boyle F; Stockler M; Lovell M; Chye R; Forder P; Briganti E, 2010, 'A randomized controlled trial of a standardized educational intervention for patients with cancer pain', Journal of Pain and Symptom Management, vol. 49, pp. 49 - 59, http://dx.doi.org/10.1016/j.jpainsymman.2009.12.013
    Journal articles | 2009
    Girgis A; Hansen V; Goldstein D, 2009, 'Are Australian oncology health professionals burning out? A view from the trenches', European Journal of Cancer, vol. 45, pp. 393 - 399, http://dx.doi.org/10.1016/j.ejca.2008.09.029
    Journal articles | 2009
    Park SB; Goldstein D; Lin CS; Krishnan AV; Friedlander ML; Kiernan MC, 2009, 'Acute abnormalities of sensory nerve function associated with oxaliplatin-induced neurotoxicity', Journal of clinical oncology - official journal of the American Society of Clinical Oncology, vol. 27, pp. 1243 - 1249, http://dx.doi.org/10.1200/JCO.2008.19.3425
    Journal articles | 2009
    Park SB; Lin CS-Y; Krishnan AV; Goldstein D; Friedlander ML; Kiernan MC, 2009, 'Oxaliplatin-induced Lhermitte’s phenomenon as a manifestation of severe generalized nerve dysfunction', Oncology, vol. 77, pp. 342 - 348, http://dx.doi.org/10.1159/000265940
    Journal articles | 2009
    Park SB; Lin CS; Krishnan AV; Goldstein D; Friedlander ML; Kiernan MC, 2009, 'Oxaliplatin-induced neurotoxicity: Changes in axonal excitability precede development of neuropathy', Brain, vol. 132, pp. 2712 - 2723, http://dx.doi.org/10.1093/brain/awp219
    Journal articles | 2008
    Park SB; Krishnan AV; Lin CS; Goldstein D; Friedlander ML; Kiernan MC, 2008, 'Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, vol. 15, pp. 3081 - 3094, http://dx.doi.org/10.2174/092986708786848569
    Journal articles | 2006
    Grimison PS; T Chin M; Harrison ML; Goldstein D, 2006, 'Primary pancreatic lymphoma - pancreatic tumours that are potentially curable without resection, a retrospective review of four cases', BMC Cancer, vol. 6, http://dx.doi.org/10.1186/1471-2407-6-117
    Journal articles | 2006
    Krishnan AV; Goldstein D; Friedlander ML; Kiernan MC, 2006, 'Oxaliplatin and axonal Na+ channel function in vivo', Clinical Cancer Research, vol. 12, pp. 4481 - 4484, http://dx.doi.org/10.1158/1078-0432.CCR-06-0694
    Journal articles | 2006
    Yip D; Karapetis C; Strickland C; Steer C; Goldstein D, 2006, 'Chemotherapy and radiotherapy for pancreatic cancer', Cochrane Database of Systematic Reviews, vol. 4, http://dx.doi.org/10.1002/14651858.CD011044.pub2
    Journal articles | 2005
    Krishnan AV; Goldstein D; Friedlander ML; Kiernan MC, 2005, 'Oxaliplatin-induced neurotoxicity and the development of neuropathy', Muscle and Nerve, vol. 32, pp. 51 - 60, http://dx.doi.org/10.1002/mus.20340
    Journal articles | 2004
    Robotin M; Law MG; Milliken ST; Goldstein D; Garsia RJ; Dolan GM; Kaldor JM; Grulich AE, 2004, 'Clinical features and predictors of survival of AIDS-related non-Hodgkin`s lymphoma in a population-based case series in Sydney, Australia', HIV Medicine, vol. 5, pp. 377 - 384, http://dx.doi.org/10.1111/j.1468-1293.2004.00238.x
    Journal articles | 1988
    Goldstein D; Laszlo J, 1988, 'The role of interferon in cancer therapy: A current perspective', CA: A Cancer Journal for Clinicians, vol. 38, pp. 258 - 277, http://dx.doi.org/10.3322/canjclin.38.5.258
  • Conference Posters | 2015
    Lim HJ; Wang X; Goldstein ; Crowe , 2015, 'Targeting the PI3K/PTEN/AKT/mTOR pathway in sarcoma cell lines', Lorne, Victoria, Australia, Vol. 36, pp. 5765 - 5771, presented at 27th Lorne Cancer Conference 2015, Lorne, Victoria, Australia, 12 February 2015 - 14 February 2015, http://dx.doi.org/10.21873/anticanres.11160
    Conference Papers | 2015
    Pothula S; Xu Z; Goldstein D; Pirola R; Wilson JS; Apte M, 2015, 'Pancreatic cancer: stromal reprogramming offers a novel therapeutic approach', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, San Diego, Pancreas 44(8):1407, pp. 1407 - 1408, presented at American Pancreatic Association, San Diego, Pancreas 44(8):1407, - , http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000363324000233&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Posters | 2015
    Wang X; Crowe PJ; Goldstein D; Yang JL, 2015, 'Overcoming resistance of targeted EGFR/panHER monotherapy by inhibition of STAT3 escape pathway in sarcoma', Lorne, Victoria, Australia, Vol. 7, pp. 21496 - 21509, presented at 27th Lorne Cancer Conference 2015, Lorne, Victoria, Australia, 12 February 2015 - 14 February 2015, http://dx.doi.org/10.18632/oncotarget.7452

AGITG JOHN ZALCBERG AWARD FOR CLINICAL RESEARCH EXCELLENCE

CANCER INSTITUTE NSW MAKE A DIFFERENCE AWARD

PEOPLES HEALTH MEDAL VIETNAM 

Prof Goldstein has extensive clinical trial experience in both design and leadership. He also participated in a number of translational studies and is an active collaborator in three laboratory programs focused upon modeling of the use of targeted agents. His activity over many years in one of the least common cancers and least studied, until recently, in the GI area – pancreas cancer, as well as GIST and biliary cancers gives him great insight into the challenges of approaching a suite of rare cancers. He has also been involved in several large scale epidemiologic studies, the most recent looking at pancreatic cancer. He has contributed to pivotal data resulting in PBS changes in approval for adjuvant gemcitabine in pancreas cancer, imatinib in metastatic and adjuvant GIST and first line nab-paclitaxel in pancreatic cancer. 

My Research Supervision

cosupervising  2x PhD in pancreatic cancer biology, one in pancreatic cancer translational science