Dr David Humphreys

Conjoint Lecturer

Bachelor of Science (Honours): 1994

Doctor of Philosophy (PhD) Biological Sciences: 1999

Medicine & Health

School of Clinical Medicine

Dr David Humphreys is a bioinformatician and lab scientist that manages the Genome core at Victor Chang Cardiac Research Institute. He specialises in generating and analysing high throughput sequencing data sets.

Book Chapters | 2014

Keam SP; Sobala A; Humphreys DT; Suter CM; Hutvagner G, 2014, 'Computational analysis, biochemical purification, and detection of tRNA-derived small RNA fragments', in Methods in Molecular Biology, pp. 157 - 167, http://dx.doi.org/10.1007/978-1-4939-0931-5_14

Book Chapters | 2010

Beilharz TH; Humphreys D; Preiss T, 2010, 'miRNA Effects on mRNA closed-loop formation during translation initiation', in Rhoads RE (ed.), miRNA Regulation of the Translational Machinery, Springer-Verlag, Berlin Heidelberg, pp. 99 - 112, http://dx.doi.org/10.1007/978-3-642-03103-8_7

Book Chapters | 2007

Humphreys DT; Westman BJ; Martin DIK; Preiss T, 2007, 'Inhibition of translation initiation by a microRNA', in MicroRNAs: From Basic Science to Disease Biology, pp. 85 - 101, http://dx.doi.org/10.1017/CBO9780511541766.009
Journal articles | 2023

Chiang IKN; Humphrey D; Mills RJ; Kaltzis P; Pachauri S; Graus M; Saha D; Wu Z; Young P; Sim CB; Davidson T; Hernandez-Garcia A; Shaw CA; Renwick A; Scott DA; Porrello ER; Wong ES; Hudson JE; Red-Horse K; del Monte-Nieto G; Francois M, 2023, 'Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction', EMBO Reports, http://dx.doi.org/10.15252/embr.202255043

Journal articles | 2023

Marjaneh MM; Kirk EP; Patrick R; Alankarage D; Humphreys DT; Monte-Nieto GD; Cornejo-Paramo P; Janbandhu V; Doan TB; Dunwoodie SL; Wong ES; Moran C; Martin ICA; Thomson PC; Harvey RP, 2023, 'Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line', eLife, 12, http://dx.doi.org/10.7554/eLife.83606

Journal articles | 2023

Mullari M; Fossat N; Skotte NH; Asenjo-Martinez A; Humphreys DT; Bukh J; Kirkeby A; Scheel TKH; Nielsen ML, 2023, 'Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-39936-x

Journal articles | 2022

Alankarage D; Enriquez A; Steiner RD; Raggio C; Higgins M; Milnes D; Humphreys DT; Duncan EL; Sparrow DB; Giampietro PF; Chapman G; Dunwoodie SL, 2022, 'Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors', Differentiation, 128, pp. 1 - 12, http://dx.doi.org/10.1016/j.diff.2022.09.002

Journal articles | 2022

Janbandhu V; Tallapragada V; Patrick R; Li Y; Abeygunawardena D; Humphreys DT; Martin EMMA; Ward AO; Contreras O; Farbehi N; Yao E; Du J; Dunwoodie SL; Bursac N; Harvey RP, 2022, 'Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction', Cell Stem Cell, 29, pp. 281 - 297.e12, http://dx.doi.org/10.1016/j.stem.2021.10.009

Journal articles | 2022

Nicks AM; Holman SR; Chan AY; Tsang M; Young PE; Humphreys DT; Naqvi N; Husain A; Li M; Smith NJ; Iismaa SE; Graham RM, 2022, 'Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts', Journal of Molecular and Cellular Cardiology, 170, pp. 47 - 59, http://dx.doi.org/10.1016/j.yjmcc.2022.05.012

Journal articles | 2022

Ridone P; Ishida T; Lin A; Humphreys DT; Giannoulatou E; Sowa Y; Baker MAB, 2022, 'The rapid evolution of flagellar ion selectivity in experimental populations of E. coli', Science Advances, 8, pp. eabq2492, http://dx.doi.org/10.1126/sciadv.abq2492

Journal articles | 2022

Tarr I; Hesselson S; Iismaa SE; Rath E; Monger S; Troup M; Mishra K; Wong CMY; Hsu PC; Junday K; Humphreys DT; Adlam D; Webb TR; Baranowska-Clarke AA; Hamby SE; Carss KJ; Samani NJ; Bax M; McGrath-Cadell L; Kovacic JC; Dunwoodie SL; Fatkin D; Muller DWM; Graham RM; Giannoulatou E, 2022, 'Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing', Circulation: Genomic and Precision Medicine, 15, pp. 267 - 277, http://dx.doi.org/10.1161/CIRCGEN.121.003527

Journal articles | 2022

Yang A; Alankarage D; Cuny H; Ip EKK; Almog M; Lu J; Das D; Enriquez A; Szot JO; Humphreys DT; Blue GM; Ho JWK; Winlaw DS; Dunwoodie SL; Giannoulatou E, 2022, 'CHDgene: A Curated Database for Congenital Heart Disease Genes', Circulation: Genomic and Precision Medicine, 15, pp. E003539 - E003539, http://dx.doi.org/10.1161/CIRCGEN.121.003539

Journal articles | 2021

Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'Abstract 11948: A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', Circulation, 144, pp. a11948 - a11948, http://dx.doi.org/10.1161/circ.144.suppl_1.11948

Journal articles | 2021

Ogawa M; Geng FS; Humphreys DT; Kristianto E; Sheng DZ; Hui SP; Zhang Y; Sugimoto K; Nakayama M; Zheng D; Hesselson D; Hodson MP; Bogdanovic O; Kikuchi K, 2021, 'Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish', Science, 372, pp. 201 - 205, http://dx.doi.org/10.1126/science.abe2762

Journal articles | 2021

Ridone P; Ishida T; Lin A; Humphreys D; Giannoulatou E; Sowa Y; Baker M, 2021, 'The rapid evolution of flagellar ion-selectivity in experimental populations of E. coli', , http://dx.doi.org/10.1101/2021.01.26.427765

Journal articles | 2021

Santiago C; Huttner I; Chand R; Humphreys D; Young P; Ward A; Fatkin D, 2021, 'TTNtv Carriers do not Have Increased Susceptibility to Chemotherapy-Induced Cardiomyopathy', Heart, Lung and Circulation, 30, pp. S97 - S97, http://dx.doi.org/10.1016/j.hlc.2021.06.018

Journal articles | 2021

2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', Circulation, 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949

Journal articles | 2020

Martin EMMA; Enriquez A; Sparrow DB; Humphreys DT; McInerney-Leo AM; Leo PJ; Duncan EL; Iyer KR; Greasby JA; Ip E; Giannoulatou E; Sheng D; Wohler E; Dimartino C; Amiel J; Capri Y; Lehalle D; Mory A; Wilnai Y; Lebenthal Y; Gharavi AG; Krzemień GG; Miklaszewska M; Steiner RD; Raggio C; Blank R; Baris Feldman H; Milo Rasouly H; Sobreira NLM; Jobling R; Gordon CT; Giampietro PF; Dunwoodie SL; Chapman G, 2020, 'Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice', Human Molecular Genetics, 29, pp. 3662 - 3678, http://dx.doi.org/10.1093/hmg/ddaa258

Journal articles | 2020

Patrick R; Humphreys DT; Janbandhu V; Oshlack A; Ho JWK; Harvey RP; Lo KK, 2020, 'Sierra: Discovery of differential transcript usage from polyA-captured single-cell RNA-seq data', Genome Biology, 21, pp. 167, http://dx.doi.org/10.1186/s13059-020-02071-7

Journal articles | 2020

Santiago C; Chand R; Humphreys D; Young P; Ward A; Huttner I; Fatkin D, 2020, '002 Titin Truncation Provides a Sensitised Template for Cardio-Depressant Effects of Alcohol', Heart, Lung and Circulation, 29, pp. S37 - S38, http://dx.doi.org/10.1016/j.hlc.2020.09.009

Journal articles | 2019

Alankarage D; Ip E; Szot JO; Munro J; Blue GM; Harrison K; Cuny H; Enriquez A; Troup M; Humphreys DT; Wilson M; Harvey RP; Sholler GF; Graham RM; Ho JWK; Kirk EP; Pachter N; Chapman G; Winlaw DS; Giannoulatou E; Dunwoodie SL, 2019, 'Identification of clinically actionable variants from genome sequencing of families with congenital heart disease', Genetics in Medicine, 21, pp. 1111 - 1120, http://dx.doi.org/10.1038/s41436-018-0296-x

Journal articles | 2019

Humphreys DT; Fossat N; Demuth M; Tam PPL; Ho JWK, 2019, 'Ularcirc: Visualization and enhanced analysis of circular RNAs via back and canonical forward splicing', Nucleic Acids Research, 47, pp. e123, http://dx.doi.org/10.1093/nar/gkz718

Journal articles | 2018

Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, http://dx.doi.org/10.1186/s13293-018-0173-y

Journal articles | 2018

Humphreys D; Fossat N; Tam P; Ho J, 2018, 'Ularcirc: Visualisation and enhanced analysis of circular RNAs via back and canonical forward splicing', , http://dx.doi.org/10.1101/318436

Journal articles | 2018

Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation. Genomic and precision medicine, 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978

Journal articles | 2017

Blue GM; Humphreys D; Szot J; Major J; Chapman G; Bosman A; Kirk EP; Sholler GF; Harvey RP; Dunwoodie SL; Winlaw DS, 2017, 'The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease', International Journal of Cardiology, 230, pp. 155 - 163, http://dx.doi.org/10.1016/j.ijcard.2016.12.024

Journal articles | 2017

Muthiah K; Humphreys DT; Robson D; Dhital K; Spratt P; Jansz P; Macdonald PS; Hayward CS, 2017, 'Longitudinal structural, functional, and cellular myocardial alterations with chronic centrifugal continuous-flow left ventricular assist device support', Journal of Heart and Lung Transplantation, 36, pp. 722 - 731, http://dx.doi.org/10.1016/j.healun.2016.05.017

Journal articles | 2017

Shi H; Enriquez A; Rapadas M; Martin EMMA; Wang R; Moreau J; Lim CK; Szot JO; Ip E; Hughes JN; Sugimoto K; Humphreys DT; McInerney-Leo AM; Leo PJ; Maghzal GJ; Halliday J; Smith J; Colley A; Mark PR; Collins F; Sillence DO; Winlaw DS; Ho JWK; Guillemin GJ; Brown MA; Kikuchi K; Thomas PQ; Stocker R; Giannoulatou E; Chapman G; Duncan EL; Sparrow DB; Dunwoodie SL, 2017, 'NAD deficiency, congenital malformations, and niacin supplementation', New England Journal of Medicine, 377, pp. 544 - 552, http://dx.doi.org/10.1056/NEJMoa1616361

Journal articles | 2016

Cropley J; Eaton S; Aiken A; Young P; Giannoulatou E; Ho JWK; Buckland M; Keam S; Hutvagner G; Humphreys D; Langley K; Henstridge D; Martin D; Febbraio M; Suter C, 2016, 'Grand paternal inheritance of an acquired metabolic trait induced by ancestral obesity is associated with sperm RNA', , http://dx.doi.org/10.1101/042101

Journal articles | 2016

Cropley JE; Eaton SA; Aiken A; Young PE; Giannoulatou E; Ho JWK; Buckland ME; Keam SP; Hutvagner G; Humphreys DT; Langley KG; Henstridge DC; Martin DIK; Febbraio MA; Suter CM, 2016, 'Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity', Molecular Metabolism, 5, pp. 699 - 708, http://dx.doi.org/10.1016/j.molmet.2016.06.008

Journal articles | 2016

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; Maclaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2016, 'Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses', American Journal of Physiology - Endocrinology and Metabolism, 310, pp. E148 - E159, http://dx.doi.org/10.1152/ajpendo.00600.2014

Journal articles | 2016

Soetanto R; Hynes CJ; Patel HR; Humphreys DT; Evers M; Duan G; Parker BJ; Archer SK; Clancy JL; Graham RM; Beilharz TH; Smith NJ; Preiss T, 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1859, pp. 744 - 756, http://dx.doi.org/10.1016/j.bbagrm.2016.03.010

Journal articles | 2015

Djordjevic D; Deshpande V; Szczesnik T; Yang A; Humphreys DT; Giannoulatou E; Ho JWK, 2015, 'Decoding the complex genetic causes of heart diseases using systems biology', Biophysical Reviews, 7, pp. 141 - 159, http://dx.doi.org/10.1007/s12551-014-0145-3

Journal articles | 2015

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2015, 'Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep', Physiological Reports, 3, http://dx.doi.org/10.14814/phy2.12495

Journal articles | 2014

Deakin CT; Deakin JJ; Ginn SL; Young P; Humphreys D; Suter CM; Alexander IE; Hallwirth CV, 2014, 'Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence', NUCLEIC ACIDS RESEARCH, 42, http://dx.doi.org/10.1093/nar/gku607

Journal articles | 2014

Giannoulatou E; Park S-H; Humphreys DT; Ho JWK, 2014, 'Verification and validation of bioinformatics software without a gold standard: a case study of BWA and Bowtie', BMC bioinformatics, 15, pp. S15 - S15, http://dx.doi.org/10.1186/1471-2105-15-S16-S15

Journal articles | 2014

Keam SP; Young PE; McCorkindale AL; Dang THY; Clancy JL; Humphreys DT; Preiss T; Hutvagner G; Martin DIK; Cropley JE; Suter CM, 2014, 'The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells', Nucleic Acids Research, 42, pp. 8984 - 8995, http://dx.doi.org/10.1093/nar/gku620

Journal articles | 2014

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; Caroline McMillen I, 2014, 'Periconceptional undernutrition programs changes in insulin-signaling molecules and micrornas in skeletal muscle in singleton and twin fetal sheep', Biology of Reproduction, 90, http://dx.doi.org/10.1095/biolreprod.113.109751

Journal articles | 2014

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2014, 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', American Journal of Physiology - Endocrinology and Metabolism, 306, http://dx.doi.org/10.1152/ajpendo.00553.2013

Journal articles | 2014

Lie S; Morrison JL; Williams-Wyss O; Zhang S; MacLaughlin SM; McMillen IC; Suter CM; Humphreys DT; Ozanne SE; Kleemann DO; Walker SK; Roberts CT, 2014, 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', American Journal of Physiology - Endocrinology and Metabolism, 306, http://dx.doi.org/10.1152/ajpendo.00456.2013

Journal articles | 2014

Muthiah K; Humphreys D; Robson D; Macdonald P; Dhital K; Jansz P; Hayward CS, 2014, 'Regression of Cellular Hypertrophy Leads to Functional Recovery Following Implantation with Centrifugal Continuous Flow Left Ventricular Assist Devices', The Journal of Heart and Lung Transplantation, 33, pp. S236 - S236, http://dx.doi.org/10.1016/j.healun.2014.01.614

Journal articles | 2013

Humphreys DT; Suter CM, 2013, 'MiRspring: A compact standalone research tool for analyzing miRNA-seq data', Nucleic Acids Research, 41, http://dx.doi.org/10.1093/nar/gkt485

Journal articles | 2013

Li CCY; Eaton SA; Young PE; Lee M; Shuttleworth R; Humphreys DT; Grau GE; Combes V; Bebawy M; Gong J; Brammah S; Buckland ME; Suter CM, 2013, 'Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells', RNA Biology, 10, pp. 1333 - 1344, http://dx.doi.org/10.4161/rna.25281

Journal articles | 2013

Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen SP; Schmitt N; Fatkin D, 2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, 67, pp. 69 - 76, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014

Journal articles | 2013

Ohanian M; Humphreys DT; Anderson E; Preiss T; Fatkin D, 2013, 'A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.', BMC genetics, 14, http://dx.doi.org/10.1186/1471-2156-14-18

Journal articles | 2013

Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, 34, pp. 3411 - 3411, http://dx.doi.org/10.1093/eurheartj/eht309.3411

Journal articles | 2013

Samaraweera SE; O'Keefe LV; Van Eyk CL; Lawlor KT; Humphreys DT; Suter CM; Richards RI, 2013, 'Modeling and analysis of repeat RNA toxicity in drosophila', Methods in Molecular Biology, 1017, pp. 173 - 192, http://dx.doi.org/10.1007/978-1-62703-438-8_13

Journal articles | 2012

Humphreys DT; Hynes CJ; Patel HR; Wei G; Cannon LE; Fatkin D; Suter CM; Clancy JL; Preiss T, 2012, 'Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function', PLoS One, 7, pp. e30933, http://dx.doi.org/10.1371/journal.pone.0030933

Journal articles | 2012

Humphreys DT; Preiss T; Hentze M, 2012, 'Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins', Cell, 149, pp. 1393 - 1406, http://dx.doi.org/10.1016/j.cell.2012.04.031

Journal articles | 2012

Squires JE; Patel HR; Nousch M; Sibbritt T; Humphreys DT; Parker BJ; Suter CM; Preiss T, 2012, 'Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA', Nucleic Acids Research, 40, pp. 5023 - 5033, http://dx.doi.org/10.1093/nar/gks144

Journal articles | 2011

Preiss T; Clancy JL; Wei G; Echner N; Humphreys D; Beilharz TH, 2011, 'mRNA isoform diversity can obscure detection of miRNA-mediated control of translation', RNA - a Publication of the RNA Society, 17, pp. 1025 - 1031, http://dx.doi.org/10.1261/rna.2567611

Journal articles | 2011

Schonrock N; Humphreys D; Preiss T; Gotz J, 2011, 'Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-beta', Journal of Molecular Neuroscience, 46, pp. 324 - 335, http://dx.doi.org/10.1007/s12031-011-9587-2

Journal articles | 2010

Larance M; Rowland AF; Hoehn KL; Humphreys D; Preiss T; Guilhaus M; James DE, 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, 9, pp. 682 - 694, http://dx.doi.org/10.1074/mcp.M900435-MCP200

Journal articles | 2010

Schonrock N; Yazi DK; Humphreys D; Staufenbiel M; Ittner LM; Preiss T; Gotz J, 2010, 'Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta', PLoS One, 5, pp. e11070, http://dx.doi.org/10.1371/journal.pone.0011070

Journal articles | 2009

Beilharz TH; Humphreys D; Clancy JL; Thermann R; Martin DI; Hentze MW; Preiss T, 2009, 'MicroRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells', PLoS One, 4, http://dx.doi.org/10.1371/journal.pone.0006783

Journal articles | 2007

Clancy JL; Nousch M; Humphreys D; Westman B; Beilharz TH; Preiss T, 2007, 'Methods to analyze microRNA-mediated control of mRNA translation', Methods in Enzymology, 431, pp. 83 - 112, http://dx.doi.org/10.1016/S0076-6879(07)31006-9

Journal articles | 2005

Humphreys D; Westman B; Martin DI; Preiss T, 2005, 'MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function', Proceedings of the National Academy of Sciences of the United States of America, 102, pp. 16961 - 16966, http://dx.doi.org/10.1073/pnas.0506482102

Journal articles | 2005

Lu DP; Read RL; Humphreys DT; Battah FM; Martin DIK; Rasko JEJ, 2005, 'PCR-based expression analysis and identification of microRNAs.', J RNAi Gene Silencing, 1, pp. 44 - 49, https://www.ncbi.nlm.nih.gov/pubmed/19771204

Journal articles | 1999

Hochgrebe TT; Humphreys D; Wilson MR; Easterbrook-Smith SB, 1999, 'A reexamination of the role of clusterin as a complement regulator', Experimental Cell Research, 249, pp. 13 - 21, http://dx.doi.org/10.1006/excr.1999.4459

Journal articles | 1999

Humphreys DT; Carver JA; Easterbrook-Smith SB; Wilson MR, 1999, 'Clusterin has chaperone-like activity similar to that of small heat shock proteins', Journal of Biological Chemistry, 274, pp. 6875 - 6881, http://dx.doi.org/10.1074/jbc.274.11.6875

Journal articles | 1999

Humphreys DT; Wilson MR, 1999, 'Modes of L929 cell death induced by TNF-α and other cytotoxic agents', Cytokine, 11, pp. 773 - 782, http://dx.doi.org/10.1006/cyto.1998.0492

Journal articles | 1997

Humphreys D; Hochgrebe TT; Easterbrook-Smith SB; Tenniswood MP; Wilson MR, 1997, 'Effects of clusterin overexpression on TNFα- and TGFβ-mediated death of L929 cells', Biochemistry, 36, pp. 15233 - 15243, http://dx.doi.org/10.1021/bi9703507
Working Papers | 2019

Patrick R; Humphreys D; Janbandhu V; Oshlack A; Ho JWK; Ho JWK; Harvey R; Lo K, 2019, Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data, http://dx.doi.org10.1101/867309
Preprints | 2023

Murtha LA; Hardy SA; Mabotuwana NS; Bigland MJ; Bailey T; Raguram K; Liu S; Ngo DT; Sverdlov AL; Tomin T; Birner-Gruenberger R; Hume RD; Iismaa SE; Humphreys DT; Patrick R; Chong JJH; Lee RJ; Harvey RP; Graham RM; Rainer PP; Boyle AJ, 2023, Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction, , http://dx.doi.org/10.21203/rs.3.rs-3055737/v1

Preprints | 2022

Marjaneh MM; Kirk E; Patrick R; Alankerage D; Humphreys D; Del Monte-Nieto G; Cornejo-Paramo P; Janbandhu V; Doan T; Dunwoodie S; Wong E; Moran C; Martin ICA; Thomson P; Harvey R, 2022, Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line, , http://dx.doi.org/10.1101/2022.10.31.514499

Preprints | 2021

Nicks A; Holman S; Chan A; Tsang M; Young P; Humphreys D; Naqvi N; Husain A; Li M; Smith N; Iismaa S; Graham R, 2021, Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts, , http://dx.doi.org/10.1101/2021.09.30.462562

Conference Papers | 2021

Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752020004371&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2021

Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in Circulation, Vol. 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949

Conference Papers | 2021

Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752020004372&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2018

Nicks AM; Humphreys DT; Holman SR; Chan AY; Djordjevic D; Naqvi N; Husain A; Smith NJ; Ho JW; Iismaa SE; Graham RM, 2018, 'Transcription Factors Driving Postnatal Cardiomyocyte Maturation', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528619405230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2017

Coleman JL; Mouat MA; Wu J; Jancovski N; Humphreys DT; Stefani M; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2017, 'Blood Pressure is Increased in Female Mice Lacking Orphan G Protein-Coupled Receptor Gpr37L1', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, VA, Pentagon City, presented at Quality of Care and Outcomes Research Scientific Sessions, VA, Pentagon City, 02 April 2017 - 03 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396815605115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2016

Nicks AM; Holman SR; Chan A; Humphreys DT; Smith NJ; Ho JW; Naqvi N; Husain A; Graham RM; Iismaa SE, 2016, 'Distinct Transcriptomic Signatures Across Postnatal Cardiomyocyte Development', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, LA, New Orleans, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, LA, New Orleans, 12 November 2016 - 16 November 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396816606015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Deakin CT; Deakin JJ; Ginn SL; Young P; Humphreys D; Suter CM; Alexander IE; Hallwirth CV, 2014, 'Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence', in Nucleic Acids Research, http://dx.doi.org/10.1093/nar/gku607

Conference Abstracts | 2013

Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, NETHERLANDS, Amsterdam, Vol. 34, pp. 642 - 642, presented at Congress of the European-Society-of-Cardiology (ESC), NETHERLANDS, Amsterdam, 31 August 2013 - 04 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327744604084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Has received a number of awards including: 2019 ABACBS Professional Bioinformatician award, 2015 listed on NHMRC reviewer honour role, 2004 St Vincents Symposium Best oral Presentation, 2004 Best oral presentation Paul Korner seminar series

Dr David Humphreys is a Senior Scientist who has training in both molecular biology and computer science. He manages the Genomics and Bioinformatics Core Facility at the Victor Chang Cardiac Research Institute where he carries out all aspects of library preparation, sequencing and downstream analysis.

Dr Humphreys has a number of active research collaborations, primarily with Victor Chang Institute faculty and St Vincent’s Hospital cardiologists, utilising RNA‐Seq and exome/genome sequencing. His contributions to projects incorporate both laboratory work and bioinformatic analysis. In the lab, he has experience in generating sequencing libraries for both RNA and DNA applications for Proton and Illumina sequencers.

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