Dr David Humphreys

Dr David Humphreys

Conjoint Lecturer

Bachelor of Science (Honours): 1994

Doctor of Philosophy (PhD) Biological Sciences:  1999

Medicine & Health
School of Clinical Medicine

Dr David Humphreys is a bioinformatician and lab scientist that manages the Genome core at Victor Chang Cardiac Research Institute. He specialises in generating and analysing high throughput sequencing data sets.

  • Book Chapters | 2014
    Keam SP; Sobala A; Humphreys DT; Suter CM; Hutvagner G, 2014, 'Computational analysis, biochemical purification, and detection of tRNA-derived small RNA fragments', in , pp. 157 - 167, http://dx.doi.org/10.1007/978-1-4939-0931-5_14
    Book Chapters | 2010
    Beilharz TH; Humphreys D; Preiss T, 2010, 'miRNA Effects on mRNA closed-loop formation during translation initiation', in Rhoads RE (ed.), miRNA Regulation of the Translational Machinery, Springer-Verlag, Berlin Heidelberg, pp. 99 - 112, http://dx.doi.org/10.1007/978-3-642-03103-8_7
    Book Chapters | 2007
    Humphreys DT; Westman BJ; Martin DIK; Preiss T, 2007, 'Inhibition of translation initiation by a microRNA', in MicroRNAs: From Basic Science to Disease Biology, pp. 85 - 101, http://dx.doi.org/10.1017/CBO9780511541766.009
  • Journal articles | 2024
    Lewis A; Humphreys DT; Pan-Castillo B; Berti G; Felice C; Gordon H; Gadhok R; Nijhuis A; Mehta S S; Eleid L; Iqbal S; Armuzzi A; Minicozzi A; Giannoulatou E; Chinaleong J; Feakins R; Sagi-Kiss V; Barisic D; Koufaki MI; Bundy JG; Lindsay JO; Silver A, 2024, 'Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn's Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets', Journal of Crohn's and Colitis, 18, pp. 895 - 907, http://dx.doi.org/10.1093/ecco-jcc/jjad209
    Journal articles | 2024
    Patrick R; Janbandhu V; Tallapragada V; Tan SSM; McKinna EE; Contreras O; Ghazanfar S; Humphreys DT; Murray NJ; Tran YTH; Hume RD; Chong JJH; Harvey RP, 2024, 'Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologies', Science Advances, 10, http://dx.doi.org/10.1126/sciadv.adk8501
    Journal articles | 2023
    Chiang IKN; Humphrey D; Mills RJ; Kaltzis P; Pachauri S; Graus M; Saha D; Wu Z; Young P; Sim CB; Davidson T; Hernandez-Garcia A; Shaw CA; Renwick A; Scott DA; Porrello ER; Wong ES; Hudson JE; Red-Horse K; del Monte-Nieto G; Francois M, 2023, 'Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction', EMBO Reports, 24, http://dx.doi.org/10.15252/embr.202255043
    Journal articles | 2023
    Marjaneh MM; Kirk EP; Patrick R; Alankarage D; Humphreys DT; Monte-Nieto GD; Cornejo-Paramo P; Janbandhu V; Doan TB; Dunwoodie SL; Wong ES; Moran C; Martin ICA; Thomson PC; Harvey RP, 2023, 'Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line', eLife, 12, http://dx.doi.org/10.7554/eLife.83606
    Journal articles | 2023
    Mullari M; Fossat N; Skotte NH; Asenjo-Martinez A; Humphreys DT; Bukh J; Kirkeby A; Scheel TKH; Nielsen ML, 2023, 'Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-39936-x
    Journal articles | 2023
    Murtha LA; Hardy SA; Mabotuwana NS; Bigland MJ; Bailey T; Raguram K; Liu S; Ngo DT; Sverdlov AL; Tomin T; Birner-Gruenberger R; Hume RD; Iismaa SE; Humphreys DT; Patrick R; Chong JJH; Lee RJ; Harvey RP; Graham RM; Rainer PP; Boyle AJ, 2023, 'Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction', Scientific Reports, 13, http://dx.doi.org/10.1038/s41598-023-41894-9
    Journal articles | 2022
    Alankarage D; Enriquez A; Steiner RD; Raggio C; Higgins M; Milnes D; Humphreys DT; Duncan EL; Sparrow DB; Giampietro PF; Chapman G; Dunwoodie SL, 2022, 'Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors', Differentiation, 128, pp. 1 - 12, http://dx.doi.org/10.1016/j.diff.2022.09.002
    Journal articles | 2022
    Janbandhu V; Tallapragada V; Patrick R; Li Y; Abeygunawardena D; Humphreys DT; Martin EMMA; Ward AO; Contreras O; Farbehi N; Yao E; Du J; Dunwoodie SL; Bursac N; Harvey RP, 2022, 'Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction', Cell Stem Cell, 29, pp. 281 - 297.e12, http://dx.doi.org/10.1016/j.stem.2021.10.009
    Journal articles | 2022
    Nicks AM; Holman SR; Chan AY; Tsang M; Young PE; Humphreys DT; Naqvi N; Husain A; Li M; Smith NJ; Iismaa SE; Graham RM, 2022, 'Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts', Journal of Molecular and Cellular Cardiology, 170, pp. 47 - 59, http://dx.doi.org/10.1016/j.yjmcc.2022.05.012
    Journal articles | 2022
    Ridone P; Ishida T; Lin A; Humphreys DT; Giannoulatou E; Sowa Y; Baker MAB, 2022, 'The rapid evolution of flagellar ion selectivity in experimental populations of E. coli', Science Advances, 8, http://dx.doi.org/10.1126/sciadv.abq2492
    Journal articles | 2022
    Tarr I; Hesselson S; Iismaa SE; Rath E; Monger S; Troup M; Mishra K; Wong CMY; Hsu PC; Junday K; Humphreys DT; Adlam D; Webb TR; Baranowska-Clarke AA; Hamby SE; Carss KJ; Samani NJ; Bax M; McGrath-Cadell L; Kovacic JC; Dunwoodie SL; Fatkin D; Muller DWM; Graham RM; Giannoulatou E, 2022, 'Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing', Circulation: Genomic and Precision Medicine, 15, pp. 267 - 277, http://dx.doi.org/10.1161/CIRCGEN.121.003527
    Journal articles | 2022
    Yang A; Alankarage D; Cuny H; Ip EKK; Almog M; Lu J; Das D; Enriquez A; Szot JO; Humphreys DT; Blue GM; Ho JWK; Winlaw DS; Dunwoodie SL; Giannoulatou E, 2022, 'CHDgene: A Curated Database for Congenital Heart Disease Genes', Circulation: Genomic and Precision Medicine, 15, pp. E003539 - E003539, http://dx.doi.org/10.1161/CIRCGEN.121.003539
    Journal articles | 2021
    Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'Abstract 11948: A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', Circulation, 144, http://dx.doi.org/10.1161/circ.144.suppl_1.11948
    Journal articles | 2021
    Ogawa M; Geng FS; Humphreys DT; Kristianto E; Sheng DZ; Hui SP; Zhang Y; Sugimoto K; Nakayama M; Zheng D; Hesselson D; Hodson MP; Bogdanovic O; Kikuchi K, 2021, 'Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish', Science, 372, http://dx.doi.org/10.1126/science.abe2762
    Journal articles | 2021
    Ridone P; Ishida T; Lin A; Humphreys D; Giannoulatou E; Sowa Y; Baker M, 2021, 'The rapid evolution of flagellar ion-selectivity in experimental populations ofE. coli', , http://dx.doi.org/10.1101/2021.01.26.427765
    Journal articles | 2021
    Santiago C; Huttner I; Chand R; Humphreys D; Young P; Ward A; Fatkin D, 2021, 'TTNtv Carriers do not Have Increased Susceptibility to Chemotherapy-Induced Cardiomyopathy', Heart, Lung and Circulation, 30, pp. S97 - S97, http://dx.doi.org/10.1016/j.hlc.2021.06.018
    Journal articles | 2021
    2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', Circulation, 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949
    Journal articles | 2020
    Martin EMMA; Enriquez A; Sparrow DB; Humphreys DT; McInerney-Leo AM; Leo PJ; Duncan EL; Iyer KR; Greasby JA; Ip E; Giannoulatou E; Sheng D; Wohler E; Dimartino C; Amiel J; Capri Y; Lehalle D; Mory A; Wilnai Y; Lebenthal Y; Gharavi AG; Krzemień GG; Miklaszewska M; Steiner RD; Raggio C; Blank R; Baris Feldman H; Milo Rasouly H; Sobreira NLM; Jobling R; Gordon CT; Giampietro PF; Dunwoodie SL; Chapman G, 2020, 'Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice', Human Molecular Genetics, 29, pp. 3662 - 3678, http://dx.doi.org/10.1093/hmg/ddaa258
    Journal articles | 2020
    Patrick R; Humphreys DT; Janbandhu V; Oshlack A; Ho JWK; Harvey RP; Lo KK, 2020, 'Sierra: Discovery of differential transcript usage from polyA-captured single-cell RNA-seq data', Genome Biology, 21, http://dx.doi.org/10.1186/s13059-020-02071-7
    Journal articles | 2020
    Santiago C; Chand R; Humphreys D; Young P; Ward A; Huttner I; Fatkin D, 2020, '002 Titin Truncation Provides a Sensitised Template for Cardio-Depressant Effects of Alcohol', Heart, Lung and Circulation, 29, pp. S37 - S38, http://dx.doi.org/10.1016/j.hlc.2020.09.009
    Journal articles | 2019
    Alankarage D; Ip E; Szot JO; Munro J; Blue GM; Harrison K; Cuny H; Enriquez A; Troup M; Humphreys DT; Wilson M; Harvey RP; Sholler GF; Graham RM; Ho JWK; Kirk EP; Pachter N; Chapman G; Winlaw DS; Giannoulatou E; Dunwoodie SL, 2019, 'Identification of clinically actionable variants from genome sequencing of families with congenital heart disease', Genetics in Medicine, 21, pp. 1111 - 1120, http://dx.doi.org/10.1038/s41436-018-0296-x
    Journal articles | 2019
    Humphreys DT; Fossat N; Demuth M; Tam PPL; Ho JWK, 2019, 'Ularcirc: Visualization and enhanced analysis of circular RNAs via back and canonical forward splicing', Nucleic Acids Research, 47, http://dx.doi.org/10.1093/nar/gkz718
    Journal articles | 2018
    Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, pp. 14, http://dx.doi.org/10.1186/s13293-018-0173-y
    Journal articles | 2018
    Humphreys D; Fossat N; Tam P; Ho J, 2018, 'Ularcirc: Visualisation and enhanced analysis of circular RNAs via back and canonical forward splicing', , http://dx.doi.org/10.1101/318436
    Journal articles | 2018
    Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation. Genomic and precision medicine, 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978
    Journal articles | 2017
    Blue GM; Humphreys D; Szot J; Major J; Chapman G; Bosman A; Kirk EP; Sholler GF; Harvey RP; Dunwoodie SL; Winlaw DS, 2017, 'The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease', International Journal of Cardiology, 230, pp. 155 - 163, http://dx.doi.org/10.1016/j.ijcard.2016.12.024
    Journal articles | 2017
    Muthiah K; Humphreys DT; Robson D; Dhital K; Spratt P; Jansz P; Macdonald PS; Hayward CS, 2017, 'Longitudinal structural, functional, and cellular myocardial alterations with chronic centrifugal continuous-flow left ventricular assist device support', Journal of Heart and Lung Transplantation, 36, pp. 722 - 731, http://dx.doi.org/10.1016/j.healun.2016.05.017
    Journal articles | 2017
    Shi H; Enriquez A; Rapadas M; Martin EMMA; Wang R; Moreau J; Lim CK; Szot JO; Ip E; Hughes JN; Sugimoto K; Humphreys DT; McInerney-Leo AM; Leo PJ; Maghzal GJ; Halliday J; Smith J; Colley A; Mark PR; Collins F; Sillence DO; Winlaw DS; Ho JWK; Guillemin GJ; Brown MA; Kikuchi K; Thomas PQ; Stocker R; Giannoulatou E; Chapman G; Duncan EL; Sparrow DB; Dunwoodie SL, 2017, 'NAD deficiency, congenital malformations, and niacin supplementation', New England Journal of Medicine, 377, pp. 544 - 552, http://dx.doi.org/10.1056/NEJMoa1616361
    Journal articles | 2016
    Cropley J; Eaton S; Aiken A; Young P; Giannoulatou E; Ho JWK; Buckland M; Keam S; Hutvagner G; Humphreys D; Langley K; Henstridge D; Martin D; Febbraio M; Suter C, 2016, 'Grand paternal inheritance of an acquired metabolic trait induced by ancestral obesity is associated with sperm RNA', , http://dx.doi.org/10.1101/042101
    Journal articles | 2016
    Cropley JE; Eaton SA; Aiken A; Young PE; Giannoulatou E; Ho JWK; Buckland ME; Keam SP; Hutvagner G; Humphreys DT; Langley KG; Henstridge DC; Martin DIK; Febbraio MA; Suter CM, 2016, 'Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity', Molecular Metabolism, 5, pp. 699 - 708, http://dx.doi.org/10.1016/j.molmet.2016.06.008
    Journal articles | 2016
    Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; Maclaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2016, 'Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses', American Journal of Physiology - Endocrinology and Metabolism, 310, pp. E148 - E159, http://dx.doi.org/10.1152/ajpendo.00600.2014
    Journal articles | 2016
    Soetanto R; Hynes CJ; Patel HR; Humphreys DT; Evers M; Duan G; Parker BJ; Archer SK; Clancy JL; Graham RM; Beilharz TH; Smith NJ; Preiss T, 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1859, pp. 744 - 756, http://dx.doi.org/10.1016/j.bbagrm.2016.03.010
    Journal articles | 2015
    Djordjevic D; Deshpande V; Szczesnik T; Yang A; Humphreys DT; Giannoulatou E; Ho JWK, 2015, 'Decoding the complex genetic causes of heart diseases using systems biology', Biophysical Reviews, 7, pp. 141 - 159
    Journal articles | 2015
    Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2015, 'Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep', Physiological Reports, 3, http://dx.doi.org/10.14814/phy2.12495
    Journal articles | 2014
    Deakin CT; Deakin JJ; Ginn SL; Young P; Humphreys D; Suter CM; Alexander IE; Hallwirth CV, 2014, 'Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence', NUCLEIC ACIDS RESEARCH, 42, http://dx.doi.org/10.1093/nar/gku607
    Journal articles | 2014
    Giannoulatou E; Park S-H; Humphreys DT; Ho JWK, 2014, 'Verification and validation of bioinformatics software without a gold standard: a case study of BWA and Bowtie', BMC bioinformatics, 15, pp. S15 - S15
    Journal articles | 2014
    Keam SP; Young PE; McCorkindale AL; Dang THY; Clancy JL; Humphreys DT; Preiss T; Hutvagner G; Martin DIK; Cropley JE; Suter CM, 2014, 'The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells', Nucleic Acids Research, 42, pp. 8984 - 8995, http://dx.doi.org/10.1093/nar/gku620
    Journal articles | 2014
    Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; Caroline McMillen I, 2014, 'Periconceptional undernutrition programs changes in insulin-signaling molecules and micrornas in skeletal muscle in singleton and twin fetal sheep', Biology of Reproduction, 90, http://dx.doi.org/10.1095/biolreprod.113.109751
    Journal articles | 2014
    Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2014, 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', American Journal of Physiology - Endocrinology and Metabolism, 306, http://dx.doi.org/10.1152/ajpendo.00553.2013
    Journal articles | 2014
    Lie S; Morrison JL; Williams-Wyss O; Zhang S; MacLaughlin SM; McMillen IC; Suter CM; Humphreys DT; Ozanne SE; Kleemann DO; Walker SK; Roberts CT, 2014, 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', American Journal of Physiology - Endocrinology and Metabolism, 306, http://dx.doi.org/10.1152/ajpendo.00456.2013
    Journal articles | 2014
    Muthiah K; Humphreys D; Robson D; Macdonald P; Dhital K; Jansz P; Hayward CS, 2014, 'Regression of Cellular Hypertrophy Leads to Functional Recovery Following Implantation with Centrifugal Continuous Flow Left Ventricular Assist Devices', The Journal of Heart and Lung Transplantation, 33, pp. S236 - S236, http://dx.doi.org/10.1016/j.healun.2014.01.614
    Journal articles | 2013
    Humphreys DT; Suter CM, 2013, 'MiRspring: A compact standalone research tool for analyzing miRNA-seq data', Nucleic Acids Research, 41, http://dx.doi.org/10.1093/nar/gkt485
    Journal articles | 2013
    Li CCY; Eaton SA; Young PE; Lee M; Shuttleworth R; Humphreys DT; Grau GE; Combes V; Bebawy M; Gong J; Brammah S; Buckland ME; Suter CM, 2013, 'Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells', RNA Biology, 10, pp. 1333 - 1344, http://dx.doi.org/10.4161/rna.25281
    Journal articles | 2013
    Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen SP; Schmitt N; Fatkin D, 2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014
    Journal articles | 2013
    Ohanian M; Humphreys DT; Anderson E; Preiss T; Fatkin D, 2013, 'A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.', BMC genetics, 14, http://dx.doi.org/10.1186/1471-2156-14-18
    Journal articles | 2013
    Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, 34, pp. 3411 - 3411, http://dx.doi.org/10.1093/eurheartj/eht309.3411
    Journal articles | 2013
    Samaraweera SE; O'Keefe LV; Van Eyk CL; Lawlor KT; Humphreys DT; Suter CM; Richards RI, 2013, 'Modeling and analysis of repeat RNA toxicity in drosophila', Methods in Molecular Biology, 1017, pp. 173 - 192, http://dx.doi.org/10.1007/978-1-62703-438-8_13
    Journal articles | 2012
    Humphreys DT; Hynes CJ; Patel HR; Wei G; Cannon LE; Fatkin D; Suter CM; Clancy JL; Preiss T, 2012, 'Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function', PLoS One, 7, pp. e30933, http://dx.doi.org/10.1371/journal.pone.0030933
    Journal articles | 2012
    Humphreys DT; Preiss T; Hentze M, 2012, 'Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins', Cell, 149, pp. 1393 - 1406, http://dx.doi.org/10.1016/j.cell.2012.04.031
    Journal articles | 2012
    Squires JE; Patel HR; Nousch M; Sibbritt T; Humphreys DT; Parker BJ; Suter CM; Preiss T, 2012, 'Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA', Nucleic Acids Research, 40, pp. 5023 - 5033, http://dx.doi.org/10.1093/nar/gks144
    Journal articles | 2011
    Preiss T; Clancy JL; Wei G; Echner N; Humphreys D; Beilharz TH, 2011, 'mRNA isoform diversity can obscure detection of miRNA-mediated control of translation', RNA - a Publication of the RNA Society, 17, pp. 1025 - 1031
    Journal articles | 2011
    Schonrock N; Humphreys D; Preiss T; Gotz J, 2011, 'Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-beta', Journal of Molecular Neuroscience, 46, pp. 324 - 335, http://dx.doi.org/10.1007/s12031-011-9587-2
    Journal articles | 2010
    Larance M; Rowland AF; Hoehn KL; Humphreys D; Preiss T; Guilhaus M; James DE, 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, 9, pp. 682 - 694, http://dx.doi.org/10.1074/mcp.M900435-MCP200
    Journal articles | 2010
    Schonrock N; Yazi DK; Humphreys D; Staufenbiel M; Ittner LM; Preiss T; Gotz J; Ke Y, 2010, 'Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta', PLoS One, 5, pp. e11070, http://dx.doi.org/10.1371/journal.pone.0011070
    Journal articles | 2009
    Beilharz TH; Humphreys D; Clancy JL; Thermann R; Martin DI; Hentze MW; Preiss T, 2009, 'MicroRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells', PLoS One, 4
    Journal articles | 2007
    Clancy JL; Nousch M; Humphreys D; Westman B; Beilharz TH; Preiss T, 2007, 'Methods to analyze microRNA-mediated control of mRNA translation', Methods in Enzymology, 431, pp. 83 - 112
    Journal articles | 2005
    Humphreys D; Westman B; Martin DI; Preiss T, 2005, 'MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function', Proceedings of the National Academy of Sciences of the United States of America, 102, pp. 16961 - 16966
    Journal articles | 2005
    Lu DP; Read RL; Humphreys DT; Battah FM; Martin DIK; Rasko JEJ, 2005, 'PCR-based expression analysis and identification of microRNAs.', J RNAi Gene Silencing, 1, pp. 44 - 49, https://www.ncbi.nlm.nih.gov/pubmed/19771204
    Journal articles | 1999
    Hochgrebe TT; Humphreys D; Wilson MR; Easterbrook-Smith SB, 1999, 'A reexamination of the role of clusterin as a complement regulator', Experimental Cell Research, 249, pp. 13 - 21, http://dx.doi.org/10.1006/excr.1999.4459
    Journal articles | 1999
    Humphreys DT; Carver JA; Easterbrook-Smith SB; Wilson MR, 1999, 'Clusterin has chaperone-like activity similar to that of small heat shock proteins', Journal of Biological Chemistry, 274, pp. 6875 - 6881, http://dx.doi.org/10.1074/jbc.274.11.6875
    Journal articles | 1999
    Humphreys DT; Wilson MR, 1999, 'Modes of L929 cell death induced by TNF-α and other cytotoxic agents', Cytokine, 11, pp. 773 - 782, http://dx.doi.org/10.1006/cyto.1998.0492
    Journal articles | 1997
    Humphreys D; Hochgrebe TT; Easterbrook-Smith SB; Tenniswood MP; Wilson MR, 1997, 'Effects of clusterin overexpression on TNFα- and TGFβ-mediated death of L929 cells', Biochemistry, 36, pp. 15233 - 15243, http://dx.doi.org/10.1021/bi9703507
  • Working Papers | 2019
    Patrick R; Humphreys D; Janbandhu V; Oshlack A; Ho JWK; Ho JWK; Harvey R; Lo K, 2019, Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data, http://dx.doi.org10.1101/867309
  • Preprints | 2024
    Bozon K; Cuny H; Sheng DZ; Martin EMMA; Young P; Humphreys DT; Dunwoodie SL, 2024, Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects, http://dx.doi.org/10.7554/elife.97649
    Preprints | 2024
    Bozon K; Cuny H; Sheng DZ; Martin EMMA; Young P; Humphreys DT; Dunwoodie SL, 2024, Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects, http://dx.doi.org/10.7554/elife.97649.1
    Preprints | 2023
    Murtha LA; Hardy SA; Mabotuwana NS; Bigland MJ; Bailey T; Raguram K; Liu S; Ngo DT; Sverdlov AL; Tomin T; Birner-Gruenberger R; Hume RD; Iismaa SE; Humphreys DT; Patrick R; Chong JJH; Lee RJ; Harvey RP; Graham RM; Rainer PP; Boyle AJ, 2023, Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction, http://dx.doi.org/10.21203/rs.3.rs-3055737/v1
    Preprints | 2022
    Marjaneh MM; Kirk E; Patrick R; Alankerage D; Humphreys D; Del Monte-Nieto G; Cornejo-Paramo P; Janbandhu V; Doan T; Dunwoodie S; Wong E; Moran C; Martin ICA; Thomson P; Harvey R, 2022, Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line, http://dx.doi.org/10.1101/2022.10.31.514499
    Preprints | 2021
    Nicks A; Holman S; Chan A; Tsang M; Young P; Humphreys D; Naqvi N; Husain A; Li M; Smith N; Iismaa S; Graham R, 2021, Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts, http://dx.doi.org/10.1101/2021.09.30.462562
    Conference Papers | 2021
    Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752020004371&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2021
    Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in Circulation, Vol. 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949
    Conference Papers | 2021
    Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752020004372&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Nicks AM; Humphreys DT; Holman SR; Chan AY; Djordjevic D; Naqvi N; Husain A; Smith NJ; Ho JW; Iismaa SE; Graham RM, 2018, 'Transcription Factors Driving Postnatal Cardiomyocyte Maturation', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528619405230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2017
    Coleman JL; Mouat MA; Wu J; Jancovski N; Humphreys DT; Stefani M; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2017, 'Blood Pressure is Increased in Female Mice Lacking Orphan G Protein-Coupled Receptor Gpr37L1', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, VA, Pentagon City, presented at Quality of Care and Outcomes Research Scientific Sessions, VA, Pentagon City, 02 April 2017 - 03 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396815605115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Nicks AM; Holman SR; Chan A; Humphreys DT; Smith NJ; Ho JW; Naqvi N; Husain A; Graham RM; Iismaa SE, 2016, 'Distinct Transcriptomic Signatures Across Postnatal Cardiomyocyte Development', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, LA, New Orleans, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, LA, New Orleans, 12 November 2016 - 16 November 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396816606015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Deakin CT; Deakin JJ; Ginn SL; Young P; Humphreys D; Suter CM; Alexander IE; Hallwirth CV, 2014, 'Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence', in Nucleic Acids Research, http://dx.doi.org/10.1093/nar/gku607
    Conference Abstracts | 2013
    Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, NETHERLANDS, Amsterdam, Vol. 34, pp. 642 - 642, presented at Congress of the European-Society-of-Cardiology (ESC), NETHERLANDS, Amsterdam, 31 August 2013 - 04 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327744604084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Has received a number of awards including: 2019 ABACBS Professional Bioinformatician award, 2015 listed on NHMRC reviewer honour role, 2004 St Vincents Symposium Best oral Presentation, 2004 Best oral presentation Paul Korner seminar series

Dr David Humphreys is a Senior Scientist who has training in both molecular biology and computer science. He manages the Genomics and Bioinformatics Core Facility at the Victor Chang Cardiac Research Institute where he carries out all aspects of library preparation, sequencing and downstream analysis.

 Dr Humphreys has a number of active research collaborations, primarily with Victor Chang Institute faculty and St Vincent’s Hospital cardiologists, utilising RNA‐Seq and exome/genome sequencing. His contributions to projects incorporate both laboratory work and bioinformatic analysis. In the lab, he has experience in generating sequencing libraries for both RNA and DNA applications for Proton and Illumina sequencers.