PhD, BSc (Advanced) (Hons)
David leads the Structural Virology Group at the EMBL Australia Node for Single Molecule Science. Having completed a bachelor of science majoring in biochemistry and chemistry, David undertook his PhD under the supervision of Professors Jill Trewhella and Mitchell Guss at the University of Sydney. During that time, David employed both crystallography and small-angle scattering to understand protein structure. He also authored the internationally accepted standards by which biological small-angle scattering data are now reported in publications. In 2012, the award of an NHMRC Early Career Fellowship enabled him to join the group of Leo James at the MRC Laboratory of Molecular Biology, Cambridge. Here he studied the role played by the HIV capsid during the early stage of infection, revealing structural dynamics and interactions with the host at a molecular level not previously seen. Since returning to Australia, David leads an independent research team focused on understanding the molecular details of host-pathogen interactions through the use of crystallographic, single molecule fluorescence, and cryo-electron microscopy methods.
2022-2024: NHMRC Ideas Grant GNT2013215 "Understanding how viruses overcome the nuclear pore complex, the gatekeeper of genomic access"
2020-2022: NHMRC Ideas Grant GNT1182212 "The HIV Capsid is a Functional Scaffold that Directs Bidirectional Cargo Transport"
2019-2024: Wellcome Trust Collaborator Award 214344/Z/18/Z "What is Special About Pandemic HIV-1? How Capsid Cofactor Interactions Regulate DNA Synthesis, Innate Immunity and Pandemic Potential"
2019-2021: NHMRC Project Grant GNT1158338 "Control of HIV Capsid Uncoating"
2019: ARC Linkage Infrastructure, Equipment and Facilities Grant LE190100165 "X-ray Facility for Protein Crystallography"
2018-2020: ARC Discovery Project DP180101384 "Regulation of DNA Synthesis and Host Evasion by Lentivirus Capsids"
2012-2017: NHMRC Early Career Fellowship GNT103652 "Proteins Involved in HIV Infection and Host Defense"