Associate Professor Deborah Cromer

Associate Professor

PhD in Mathematical Biology (Imperial College, London UK, 2008)
BSc (Hons Class 1 and University Medal) in Mathematics and Computer Science (UNSW, 2000)

Medicine & Health

The Kirby Institute

Associate Professor Deborah Cromer leads the Infection Epidemiology and Policy Analytics Group in the Infection Analytics Program at the Kirby Institute, UNSW. She has made significant contributions to understanding immune correlates of infection for COVID-19, and her work has influenced vaccination policy internationally. She has also assisted with public understanding of immunity and vaccination through frequent media contributions and appearances, and presentations in public science forums and to school students. She is passionate about encouraging and supporting females to engage and excel in mathematics. She holds an NHMRC Investigator Fellowship.

Specific Research Keywords:
COVID-19, SARS-CoV-2, Mathematical Biology, Mathematical Modelling, Mathematics, Malaria, Theoretical Biology, HIV, CMV, Vaccination Policy, Influenza, Rotavirus, RSV

Phone

9385 8194

E-mail

d.cromer@unsw.edu.au

Journal articles | 2024

Cromer D; Reynaldi A; Mitchell A; Schlub TE; Juno JA; Wheatley AK; Kent SJ; Khoury DS; Davenport MP, 2024, 'Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-52194-9

Journal articles | 2024

Elias KM; Khan SR; Stadler E; Schlub TE; Cromer D; Polizzotto MN; Kent SJ; Turner T; Davenport MP; Khoury DS, 2024, 'Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: a systematic review and meta-analysis', The Lancet Microbe, 5, pp. e459 - e467, http://dx.doi.org/10.1016/S2666-5247(23)00398-1

Journal articles | 2024

Hastak P; Cromer D; Malycha J; Andersen CR; Raith E; Davenport MP; Plummer M; Sasson SC, 2024, 'Defining the correlates of lymphopenia and independent predictors of poor clinical outcome in adults hospitalized with COVID-19 in Australia', Scientific Reports, 14, http://dx.doi.org/10.1038/s41598-024-61729-5

Journal articles | 2024

Revoltar M; van der Linde R; Cromer D; Gatt PN; Smith S; Fernandez MA; Vaughan L; Blyth E; Curnow J; Tegg E; Brown DA; Sasson SC, 2024, 'Indeterminate measurable residual disease by multiparameter flow cytometry is associated with an intermediate risk of clinical relapse in adult patients with acute leukaemia', Pathology, 56, pp. 882 - 888, http://dx.doi.org/10.1016/j.pathol.2024.04.009

Journal articles | 2023

Cromer D; Steain M; Reynaldi A; Schlub TE; Khan SR; Sasson SC; Kent SJ; Khoury DS; Davenport MP, 2023, 'Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis', Nature Communications, 14, pp. 1633, http://dx.doi.org/10.1038/s41467-023-37176-7

Journal articles | 2023

Docken SS; McCormick K; Pampena MB; Samer S; Lindemuth E; Pinkevych M; Viox EG; Wu Y; Schlub TE; Cromer D; Keele BF; Paiardini M; Betts MR; Bar KJ; Davenport MP, 2023, 'Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency', PLoS Pathogens, 19, http://dx.doi.org/10.1371/journal.ppat.1011755

Journal articles | 2023

Khoury DS; Docken SS; Subbarao K; Kent SJ; Davenport MP; Cromer D, 2023, 'Predicting the efficacy of variant-modified COVID-19 vaccine boosters', Nature Medicine, 29, pp. 574 - 578, http://dx.doi.org/10.1038/s41591-023-02228-4

Journal articles | 2023

Khoury DS; Schlub TE; Cromer D; Steain M; Fong Y; Gilbert PB; Subbarao K; Triccas JA; Kent SJ; Davenport MP, 2023, 'Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection', Emerging Infectious Diseases, 29, pp. 381 - 388, http://dx.doi.org/10.3201/eid2902.221422

Journal articles | 2023

Lee WS; Tan HX; Reynaldi A; Esterbauer R; Koutsakos M; Nguyen J; Amarasena T; Kent HE; Aggarwal A; Turville SG; Taiaroa G; Kinsella P; Liew KC; Tran T; Williamson DA; Cromer D; Davenport MP; Kent SJ; Juno JA; Khoury DS; Wheatley AK, 2023, 'Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adg5301

Journal articles | 2023

Selva KJ; Ramanathan P; Haycroft ER; Reynaldi A; Cromer D; Tan CW; Wang LF; Wines BD; Hogarth PM; Downie LE; Davis SK; Purcell RA; Kent HE; Juno JA; Wheatley AK; Davenport MP; Kent SJ; Chung AW, 2023, 'Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections', JCI Insight, 8, http://dx.doi.org/10.1172/jci.insight.172470

Journal articles | 2023

Stadler E; Burgess MT; Schlub TE; Khan SR; Chai KL; McQuilten ZK; Wood EM; Polizzotto MN; Kent SJ; Cromer D; Davenport MP; Khoury DS, 2023, 'Monoclonal antibody levels and protection from COVID-19', Nature Communications, 14, pp. 4545, http://dx.doi.org/10.1038/s41467-023-40204-1

Journal articles | 2023

Stadler E; Chai KL; Schlub TE; Cromer D; Khan SR; Polizzotto MN; Kent SJ; Beecher C; White H; Turner T; Skoetz N; Estcourt L; McQuilten ZK; Wood EM; Khoury DS; Davenport MP, 2023, 'Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis', The Lancet Microbe, 4, pp. e883 - e892, http://dx.doi.org/10.1016/S2666-5247(23)00194-5

Journal articles | 2023

Stadler E; Cromer D; Ogunlade S; Ongoiba A; Doumbo S; Kayentao K; Traore B; Crompton PD; Portugal S; Davenport MP; Khoury DS, 2023, 'Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data', Malaria Journal, 22, http://dx.doi.org/10.1186/s12936-023-04461-1

Journal articles | 2023

Zachreson C; Tobin R; Szanyi J; Walker C; Cromer D; Shearer FM; Conway E; Ryan G; Cheng A; McCaw JM; Geard N, 2023, 'Individual variation in vaccine immune response can produce bimodal distributions of protection', Vaccine, 41, pp. 6630 - 6636, http://dx.doi.org/10.1016/j.vaccine.2023.09.025

Journal articles | 2022

Aggarwal A; Stella A; Walker G; Akerman A; Milogiannakis V; Brilot F; Amatayakul-Chantler S; Roth N; Coppola G; Schofield P; Jackson J; Lenthall H; Mazigi O; Langley D; Lu Y; Forster C; McAllery S; Mathivanan V; Fitcher C; Hoppe AC; Munier ML; Jack H-M; Cromer D; Darley D; Matthews G; Christ D; Khoury D; Davenport M; Rawlinson W; Kelleher A; Turville S, 2022, 'SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern', , http://dx.doi.org/10.21203/rs.3.rs-1207364/v1

Journal articles | 2022

Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7

Journal articles | 2022

Cele S; Jackson L; Khoury DS; Khan K; Moyo-Gwete T; Tegally H; San JE; Cromer D; Scheepers C; Amoako DG; Karim F; Bernstein M; Lustig G; Archary D; Smith M; Ganga Y; Jule Z; Reedoy K; Hwa SH; Giandhari J; Blackburn JM; Gosnell BI; Abdool Karim SS; Hanekom W; Davies MA; Hsiao M; Martin D; Mlisana K; Wibmer CK; Williamson C; York D; Harrichandparsad R; Herbst K; Jeena P; Khoza T; Kløverpris H; Leslie A; Madansein R; Magula N; Manickchund N; Marakalala M; Mazibuko M; Moshabela M; Mthabela N; Naidoo K; Ndhlovu Z; Ndung’u T; Ngcobo N; Nyamande K; Patel V; Smit T; Steyn A; Wong E; von Gottberg A; Bhiman JN; Lessells RJ; Moosa MYS; Davenport MP; de Oliveira T; Moore PL; Sigal A, 2022, 'Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization', Nature, 602, pp. 654 - 656, http://dx.doi.org/10.1038/s41586-021-04387-1

Journal articles | 2022

Cromer D; Reynaldi A; Steain M; Triccas JA; Davenport MP; Khoury DS, 2022, 'Relating in Vitro Neutralization Level and Protection in the CVnCoV (CUREVAC) Trial', Clinical Infectious Diseases, 75, pp. E878 - E879, http://dx.doi.org/10.1093/cid/ciac075

Journal articles | 2022

Cromer D; Steain M; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Kent SJ; Triccas JA; Khoury DS; Davenport MP, 2022, 'Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis', The Lancet Microbe, 3, pp. e52 - e61, http://dx.doi.org/10.1016/S2666-5247(21)00267-6

Journal articles | 2022

Kent SJ; Khoury DS; Reynaldi A; Juno JA; Wheatley AK; Stadler E; John Wherry E; Triccas J; Sasson SC; Cromer D; Davenport MP, 2022, 'Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?', Nature Reviews Immunology, 22, pp. 387 - 397, http://dx.doi.org/10.1038/s41577-022-00716-1

Journal articles | 2022

Koutsakos M; Lee WS; Reynaldi A; Tan HX; Gare G; Kinsella P; Liew KC; Taiaroa G; Williamson DA; Kent HE; Stadler E; Cromer D; Khoury DS; Wheatley AK; Juno JA; Davenport MP; Kent SJ, 2022, 'The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants', Immunity, 55, pp. 1316 - 1326.e4, http://dx.doi.org/10.1016/j.immuni.2022.05.018

Journal articles | 2022

SheelaNair A; Romanczuk AS; Aogo RA; Haldar RN; Lansink LIM; Cromer D; Salinas YG; Guy RK; McCarthy JS; Davenport MP; Haque A; Khoury DS, 2022, 'Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice', Malaria Journal, 21, http://dx.doi.org/10.1186/s12936-022-04075-z

Journal articles | 2022

Stadler E; Cromer D; Mehra S; Adekunle AI; Flegg JA; Anstey NM; Watson JA; Chu CS; Mueller I; Robinson LJ; Schlub TE; Davenport MP; Khoury DS, 2022, 'Population heterogeneity in Plasmodium vivax relapse risk', PLoS Neglected Tropical Diseases, 16, http://dx.doi.org/10.1371/journal.pntd.0010990

Journal articles | 2022

2022, 'PP 2.3 – 00034 CD8+ T-Cell Sieving During SIV Reactivation from Latency', Journal of Virus Eradication, 8, pp. 100159 - 100159, http://dx.doi.org/10.1016/j.jve.2022.100159

Journal articles | 2021

Cromer D; Juno JA; Khoury D; Reynaldi A; Wheatley AK; Kent SJ; Davenport MP, 2021, 'Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection', Nature Reviews Immunology, 21, pp. 395 - 404, http://dx.doi.org/10.1038/s41577-021-00550-x

Journal articles | 2021

Cromer D; Reynaldi A; Steain M; Triccas J; Davenport M; Khoury D, 2021, 'Relating in vitro neutralisation level and protection in the CVnCoV (CUREVAC) trial', , http://dx.doi.org/10.1101/2021.06.29.21259504

Journal articles | 2021

Cromer D; Steain M; Reynaldi A; Schlub T; Wheatley A; Juno J; Kent S; Triccas J; Khoury D; Davenport M, 2021, 'SARS-CoV-2 variants: levels of neutralisation required for protective immunity', , http://dx.doi.org/10.1101/2021.08.11.21261876

Journal articles | 2021

Khoury D; Cromer D; Reynaldi A; Schlub T; Wheatley A; Juno J; Subbarao K; Kent S; Triccas J; Davenport M, 2021, 'What level of neutralising antibody protects from COVID-19?', , http://dx.doi.org/10.1101/2021.03.09.21252641

Journal articles | 2021

Khoury DS; Cromer D; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Subbarao K; Kent SJ; Triccas JA; Davenport MP, 2021, 'Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection', Nature Medicine, 27, pp. 1205 - 1211, http://dx.doi.org/10.1038/s41591-021-01377-8

Journal articles | 2021

Lee WS; Selva KJ; Davis SK; Wines BD; Reynaldi A; Esterbauer R; Kelly HG; Haycroft ER; Tan HX; Juno JA; Wheatley AK; Hogarth PM; Cromer D; Davenport MP; Chung AW; Kent SJ, 2021, 'Decay of Fc-dependent antibody functions after mild to moderate COVID-19', Cell Reports Medicine, 2, http://dx.doi.org/10.1016/j.xcrm.2021.100296

Journal articles | 2021

Pymm P; Adair A; Chan LJ; Cooney JP; Mordant FL; Allison CC; Lopez E; Haycroft ER; O'Neill MT; Tan LL; Dietrich MH; Drew D; Doerflinger M; Dengler MA; Scott NE; Wheatley AK; Gherardin NA; Venugopal H; Cromer D; Davenport MP; Pickering R; Godfrey DI; Purcell DFJ; Kent SJ; Chung AW; Subbarao K; Pellegrini M; Glukhova A; Tham WH, 2021, 'Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2101918118

Journal articles | 2021

Wheatley AK; Juno JA; Wang JJ; Selva KJ; Reynaldi A; Tan HX; Lee WS; Wragg KM; Kelly HG; Esterbauer R; Davis SK; Kent HE; Mordant FL; Schlub TE; Gordon DL; Khoury DS; Subbarao K; Cromer D; Gordon TP; Chung AW; Davenport MP; Kent SJ, 2021, 'Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-21444-5

Journal articles | 2021

Wheatley AK; Pymm P; Esterbauer R; Dietrich MH; Lee WS; Drew D; Kelly HG; Chan LJ; Mordant FL; Black KA; Adair A; Tan HX; Juno JA; Wragg KM; Amarasena T; Lopez E; Selva KJ; Haycroft ER; Cooney JP; Venugopal H; Tan LL; O Neill MT; Allison CC; Cromer D; Davenport MP; Bowen RA; Chung AW; Pellegrini M; Liddament MT; Glukhova A; Subbarao K; Kent SJ; Tham WH, 2021, 'Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain', Cell Reports, 37, http://dx.doi.org/10.1016/j.celrep.2021.109822

Journal articles | 2020

Alahmadi A; Belet S; Black A; Cromer D; Flegg JA; House T; Jayasundara P; Keith JM; McCaw JM; Moss R; Ross JV; Shearer FM; Tun STT; Walker CR; White L; Whyte JM; Yan AWC; Zarebski AE, 2020, 'Influencing public health policy with data-informed mathematical models of infectious diseases: Recent developments and new challenges', Epidemics, 32, http://dx.doi.org/10.1016/j.epidem.2020.100393

Journal articles | 2020

Khoury DS; Wheatley AK; Ramuta MD; Reynaldi A; Cromer D; Subbarao K; O’Connor DH; Kent SJ; Davenport MP, 2020, 'Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models', Nature Reviews Immunology, 20, pp. 727 - 738, http://dx.doi.org/10.1038/s41577-020-00471-1

Journal articles | 2020

Khoury DS; Zaloumis SG; Grigg MJ; Haque A; Davenport MP; Cromer D; Rebelo M; Cao P; McCaw JM; Simpson JA; Flegg JA; Wilson DW; Anstey NM; McCarthy JS, 2020, 'Malaria Parasite Clearance: What Are We Really Measuring?', Trends in Parasitology, 36, pp. 413 - 426, http://dx.doi.org/10.1016/j.pt.2020.02.005

Journal articles | 2020

Price DJ; Shearer FM; Meehan MT; McBryde E; Moss R; Golding N; Conway EJ; Dawson P; Cromer D; Wood J; Abbott S; McVernon J; McCaw JM, 2020, 'Early analysis of the australian covid-19 epidemic', eLife, 9, pp. 1 - 14, http://dx.doi.org/10.7554/ELIFE.58785

Journal articles | 2020

Wu Y; Pinkevych M; Xu Z; Keele BF; Davenport MP; Cromer D, 2020, 'Impact of fluctuation in frequency of human immunodeficiency virus/simian immunodeficiency virus reactivation during antiretroviral therapy interruption', Proceedings of the Royal Society B: Biological Sciences, 287, http://dx.doi.org/10.1098/rspb.2020.0354

Journal articles | 2019

Akter J; Khoury DS; Aogo R; Lansink LIM; SheelaNair A; Thomas BS; Laohamonthonkul P; Pernold CPS; Dixon MWA; Soon MSF; Fogg LG; Engel JA; Elliott T; Sebina I; James KR; Cromer D; Davenport MP; Haque A, 2019, 'Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells', PLoS Pathogens, 15, pp. e1007599, http://dx.doi.org/10.1371/journal.ppat.1007599

Journal articles | 2019

Davenport MP; Khoury DS; Cromer D; Lewin SR; Kelleher AD; Kent SJ, 2019, 'Functional cure of HIV: the scale of the challenge', Nature Reviews Immunology, 19, pp. 45 - 54, http://dx.doi.org/10.1038/s41577-018-0085-4

Journal articles | 2019

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2019, 'Corrigendum: Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration (Journal of Infectious Diseases (2016) 214 (753-761) DOI: 10.1093/infdis/jiw234)', Journal of Infectious Diseases, 219, pp. 1852 - 1853, http://dx.doi.org/10.1093/infdis/jiy729

Journal articles | 2019

Pinkevych M; Fennessey CM; Cromer D; Reid C; Trubey CM; Lifson JD; Keele BF; Davenport MP, 2019, 'Predictors of SIV recrudescence following antiretroviral treatment interruption', eLife, 8, pp. e49022, http://dx.doi.org/10.7554/eLife.49022

Journal articles | 2018

Aogo RA; Khoury DS; Cromer D; Elliott T; Akter J; Fogg LG; Nair AS; Liligeto UN; Soon MSF; Thomas BS; Pernold CPS; Romanczuk AS; Laohamonthonkul P; Haque A; Davenport MP, 2018, 'Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice', International Journal for Parasitology, 48, pp. 903 - 913, http://dx.doi.org/10.1016/j.ijpara.2018.05.010

Journal articles | 2018

Khoury DS; Aogo R; Randriafanomezantsoa-Radohery G; McCaw JM; Simpson JA; McCarthy JS; Haque A; Cromer D; Davenport MP, 2018, 'Within-host modeling of blood-stage malaria', Immunological Reviews, 285, pp. 168 - 193, http://dx.doi.org/10.1111/imr.12697

Journal articles | 2018

Parsons MS; Cromer D; Davenport MP; Kent SJ, 2018, 'HIV Reactivation after Partial Protection by Neutralizing Antibodies', Trends in Immunology, 39, pp. 359 - 366, http://dx.doi.org/10.1016/j.it.2017.12.006

Journal articles | 2018

Pinkevych M; Fennessey CM; Cromer D; Tolstrup M; Søgaard OS; Rasmussen TA; Keele BF; Davenport MP, 2018, 'Estimating initial viral levels during simian immunodeficiency virus/human immunodeficiency virus reactivation from latency', Journal of Virology, 92, http://dx.doi.org/10.1128/JVI.01667-17

Journal articles | 2018

Zaloumis SG; Cao P; Dini S; Davenport MP; Cromer D; Khoury DS; Fowkes FJI; McCaw JM; Simpson JA, 2018, 'In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance', Antimicrobial Agents and Chemotherapy, 62, pp. 10.1128/aac.01292 - 10.1128/aac.01218, http://dx.doi.org/10.1128/AAC.01292-18

Journal articles | 2017

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, 'A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection', Journal of Theoretical Biology, 430, pp. 117 - 127, http://dx.doi.org/10.1016/j.jtbi.2017.07.017

Journal articles | 2017

Cromer D; Pinkevych M; Rasmussen TA; Lewin SR; Kent SJ; Davenport MP, 2017, 'Modeling of antilatency treatment in HIV: What is the optimal duration of antiretroviral therapy-free HIV remission?', Journal of Virology, 91, pp. 10.1128/jvi.01395 - 10.1128/jvi.01317, http://dx.doi.org/10.1128/JVI.01395-17

Journal articles | 2017

Cromer D; van Hoek AJ; Newall AT; Pollard AJ; Jit M, 2017, 'Burden of paediatric respiratory syncytial virus disease and potential effect of different immunisation strategies: a modelling and cost-effectiveness analysis for England', The Lancet Public Health, 2, pp. e367 - e374, http://dx.doi.org/10.1016/S2468-2667(17)30103-2

Journal articles | 2017

Khoury DS; Cromer D; Akter J; Sebina I; Elliott T; Thomas BS; Soon MSF; James KR; Best SE; Haque A; Davenport MP, 2017, 'Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 7701 - 7706, http://dx.doi.org/10.1073/pnas.1618939114

Journal articles | 2017

Khoury DS; Cromer D; Elliott T; Soon MSF; Thomas BS; James KR; Best SE; Aogo RA; Engel JA; Gartlan KH; Akter J; Sebina I; Haque A; Davenport MP, 2017, 'Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo', International Journal for Parasitology, 47, pp. 913 - 922, http://dx.doi.org/10.1016/j.ijpara.2017.05.009

Journal articles | 2016

Adekunle AI; Cromer D; Davenport MP, 2016, 'Artemisinin-based treatments in pregnant women with malaria', New England Journal of Medicine, 375, pp. 283, http://dx.doi.org/10.1056/NEJMc1604709

Journal articles | 2016

Cromer D; Grimm AJ; Schlub TE; Mak J; Davenport MP, 2016, 'Estimating the in-vivo HIV template switching and recombination rate', AIDS, 30, pp. 185 - 192, http://dx.doi.org/10.1097/QAD.0000000000000936

Journal articles | 2016

Cromer D; Schlub TE; Smyth RP; Grimm AJ; Chopra A; Mallal S; Davenport MP; Mak J, 2016, 'HIV-1 mutation and recombination rates are different in macrophages and T-cells', Viruses, 8, pp. 118, http://dx.doi.org/10.3390/v8040118

Journal articles | 2016

Griffin P; Pasay C; Elliott S; Sekuloski S; Sikulu M; Hugo L; Khoury D; Cromer D; Davenport M; Sattabongkot J; Ivinson K; Ockenhouse C; McCarthy J, 2016, 'Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission', PLoS Neglected Tropical Diseases, 10, pp. e0005139, http://dx.doi.org/10.1371/journal.pntd.0005139

Journal articles | 2016

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2016, 'Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration', Journal of Infectious Diseases, 214, pp. 753 - 761, http://dx.doi.org/10.1093/infdis/jiw234

Journal articles | 2016

Pinkevych M; Cromer D; Tolstrup M; Grimm AJ; Cooper DA; Lewin SR; Søgaard OS; Rasmussen TA; Kent SJ; Kelleher AD; Davenport MP, 2016, 'Erratum: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission (PLoS Pathogens (2015) 11:7 (e1005000) DOI: 10.1371/journal.ppat.1005000)', PLoS Pathogens, 12, pp. e1005745, http://dx.doi.org/10.1371/journal.ppat.1005745

Journal articles | 2016

Pinkevych M; Kent SJ; Tolstrup M; Lewin SR; Cooper DA; Søgaard OS; Rasmussen TA; Kelleher AD; Cromer D; Davenport MP, 2016, 'Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5–8 Days', PLoS Pathogens, 12, pp. e1005740, http://dx.doi.org/10.1371/journal.ppat.1005740

Journal articles | 2015

Adekunle AI; Pinkevych M; McGready R; Luxemburger C; White LJ; Nosten F; Cromer D; Davenport MP, 2015, 'Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo', PLoS Neglected Tropical Diseases, 9, pp. e0003595, http://dx.doi.org/10.1371/journal.pntd.0003595

Journal articles | 2015

Bilcke J; Chapman R; Atchison C; Cromer D; Johnson H; Willem L; Cox M; Edmunds WJ; Jit M, 2015, 'Quantifying Parameter and Structural Uncertainty of Dynamic Disease Transmission Models Using MCMC: An Application to Rotavirus Vaccination in England and Wales', Medical Decision Making, 35, pp. 633 - 647, http://dx.doi.org/10.1177/0272989X14566013

Journal articles | 2015

Fraser ST; Midwinter RG; Coupland LA; Kong S; Berger BS; Yeo JH; Andrade OC; Cromer D; Suarna C; Lam M; Maghzal GJ; Chong BH; Parish CR; Stocker R, 2015, 'Heme oxygenase-1 deficiency alters erythroblastic Island formation, steady-state erythropoiesis and red blood cell lifespan in mice', Haematologica, 100, pp. 601 - 610, http://dx.doi.org/10.3324/haematol.2014.116368

Journal articles | 2015

Khoury DS; Cromer D; Best SE; James KR; Sebina I; Haque A; Davenport MP, 2015, 'Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria', Scientific Reports, 5, pp. 9412, http://dx.doi.org/10.1038/srep09412

Journal articles | 2015

Martyushev AP; Petravic J; Grimm AJ; Alinejad-Rokny H; Gooneratne SL; Reece JC; Cromer D; Kent SJ; Davenport MP, 2015, 'Epitope-specific CD8⁺ T cell kinetics rather than viral variability determine the timing of immune escape in simian immunodeficiency virus infection', Journal of Immunology, 194, pp. 4112 - 4121, http://dx.doi.org/10.4049/jimmunol.1400793

Journal articles | 2015

Pinkevych M; Cromer D; Tolstrup M; Grimm AJ; Cooper DA; Lewin SR; Søgaard OS; Rasmussen TA; Kent SJ; Kelleher AD; Davenport MP, 2015, 'HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission', PLoS Pathogens, 11, pp. e1005000, http://dx.doi.org/10.1371/journal.ppat.1005000

Journal articles | 2015

Tey SK; Davenport MP; Hill GR; Kennedy GA; Durrant ST; Khanna R; Cromer D, 2015, 'Post transplant CMV-specific T-cell immune reconstitution in the absence of global T-cell immunity is associated with a high risk of subsequent virus reactivation', Bone Marrow Transplantation, 50, pp. 315 - 316, http://dx.doi.org/10.1038/bmt.2014.265

Journal articles | 2015

Waugh C; Cromer D; Grimm A; Chopra A; Mallal S; Davenport M; Mak J, 2015, 'A general method to eliminate laboratory induced recombinants during massive, parallel sequencing of cDNA library', Virology Journal, 12, pp. 55, http://dx.doi.org/10.1186/s12985-015-0280-x

Journal articles | 2014

Schlub TE; Grimm AJ; Smyth RP; Cromer D; Chopra A; Mallal S; Venturi V; Waugh C; Mak J; Davenport MP, 2014, 'Fifteen to twenty percent of HIV substitution mutations are associated with recombination', Journal of Virology, 88, pp. 3837 - 3849, http://dx.doi.org/10.1128/JVI.03136-13

Journal articles | 2014

Smyth RP; Schlub TE; Grimm AJ; Waugh C; Ellenberg P; Chopra A; Mallal S; Cromer D; Mak J; Davenport MP, 2014, 'Identifying Recombination Hot Spots in the HIV-1 Genome', Journal of Virology, 88, pp. 2891 - 2902, http://dx.doi.org/10.1128/JVI.03014-13

Journal articles | 2014

Yabas M; Coupland LA; Cromer D; Winterberg M; Teoh NC; D'rozario J; Kirk K; Bröer S; Parish CR; Enders A, 2014, 'Mice deficient in the putative phospholipid flippase Atp11c exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span', Journal of Biological Chemistry, 289, pp. 19531 - 19537, http://dx.doi.org/10.1074/jbc.C114.570267

Journal articles | 2013

Cromer D; Best SE; Engwerda CR; Haque AKMM; Davenport MP, 2013, 'Where Have All the Parasites Gone? Modelling Early Malaria Parasite Sequestration Dynamics', PLoS ONE, 8, pp. Article number 55961, http://dx.doi.org/10.1371/journal.pone.0055961

Journal articles | 2013

Cromer D; Tey SK; Khanna R; Davenport MP, 2013, 'Estimating cytomegalovirus growth rates by using only a single point', Journal of Virology, 87, pp. 3376 - 3381, http://dx.doi.org/10.1128/JVI.02821-12

Journal articles | 2013

Cromer D; van Hoek AJ; Jit M; Edmunds WJ; Fleming D; Miller E, 2013, 'The burden of influenza in England by age and clinical risk group: A statistical analysis to inform vaccine policy', Journal of Infection, 68, pp. 363 - 371, http://dx.doi.org/10.1016/j.jinf.2013.11.013

Journal articles | 2013

Khoury DS; Cromer D; Best SE; James KR; Kim PS; Engwerda CR; Haque A; Davenport MP, 2013, 'Effect of mature, blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria.', Infection and Immunity, 82, pp. 212 - 220, http://dx.doi.org/10.1128/IAI.00705-13

Journal articles | 2013

Lucy C; Yabas M; Cromer D; Winterberg M; Teoh N; Kirk K; Broer S; Parish C; Enders A, 2013, 'Anemia, Shortened Erythrocyte Lifespan and Stomatocytosis In a Flippase Mutant Mouse Strain', Blood, 122, pp. 2183 - 2183, http://dx.doi.org/10.1182/blood.v122.21.2183.2183

Journal articles | 2013

Tey SK; Kennedy GA; Cromer D; Davenport MP; Walker S; Jones LI; Crough T; Durrant ST; Morton JA; Butler JP; Misra AK; Hill GR; Khanna R, 2013, 'Clinical Assessment of Anti-Viral CD8+ T Cell Immune Monitoring Using QuantiFERON-CMV® Assay to Identify High Risk Allogeneic Hematopoietic Stem Cell Transplant Patients with CMV Infection Complications', PLoS ONE, 8, pp. e74744, http://dx.doi.org/10.1371/journal.pone.0074744

Journal articles | 2010

Chan ML; Petravic J; Ortiz AM; Engram J; Paiardini M; Cromer D; Silvestri G; Davenport MP, 2010, 'Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys', Proceedings of the Royal Society of London Series B - Biological Sciences, 277, pp. 3773 - 3781

Journal articles | 2010

Coupland LA; Cromer D; Davenport MP; Parish CR, 2010, 'A novel fluorescent-based assay reveals that thrombopoietin signaling and Bcl-X(L) influence, respectively, platelet and erythrocyte lifespans', Experimental Hematology, 38, pp. 453 - 461

Journal articles | 2010

Cromer D; Wolinsky S; Mclean A, 2010, 'How fast could HIV change gene frequencies in the human population?', Proceedings of the Royal Society B - Biological Sciences, 277, pp. 1981 - 1989

Journal articles | 2010

Jit M; Cromer D; Baguelin M; Stowe J; Andrews N; Miller E, 2010, 'The cost-effectiveness of vaccinating pregnant women against seasonal influenza in England and Wales', Vaccine, 29, pp. 115 - 122

Journal articles | 2009

Cromer D; Christophides G; Stark J, 2009, 'Hidden variable analysis of transcription factor cooperativity from microarray time courses', IET Systems Biology, 4, pp. 131 - 144

Journal articles | 2009

Cromer D; Stark J; Davenport MP, 2009, 'Low red cell production may protect against severe anemia during a malaria infection--insights from modeling', Journal of Theoretical Biology, 257, pp. 533 - 542

Journal articles | 2006

Cromer D; Evans KJ; Schofield L; Davenport MP, 2006, 'Preferential invasion of reticulocytes during late-stage Plasmodium berghei infection accounts for reduced circulating reticulocyte levels', International Journal for Parasitology, 36, pp. 1389 - 1397
Working Papers | 2021

Cele S; Jackson L; Khoury DS; Khan K; Moyo-Gwete T; Tegally H; San JE; Cromer D; Scheepers C; Amoako D; Karim F; Bernstein M; Lustig G; Archary D; Smith M; Ganga Y; Jule Z; Reedoy K; Hwa S-H; Giandhari J; Blackburn JM; Gosnell BI; Abdool Karim SS; Hanekom W; NGS-SA ; COMMIT-KZN Team ; von Gottberg A; Bhiman J; Lessells RJ; Moosa M-YS; Davenport MP; de Oliveira T; Moore PL; Sigal A, 2021, SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection., http://dx.doi.org10.1101/2021.12.08.21267417, https://www.ncbi.nlm.nih.gov/pubmed/34909788
Preprints | 2024

Conway E; Walker C; Lydeamore M; Golding N; Ryan G; Mavec D; Oates J; Kabashima G; Price DJ; Shearer F; Cromer D; Davenport MP; McCaw J; Eriksson EM; Hodgkin PD; Wu L; Le TP; Baker CM; Mueller I; McVernon J, 2024, Optimal timing of booster doses in a highly vaccinated population with minimal natural exposure to COVID-19, , http://dx.doi.org/10.1101/2024.05.14.24307386

Preprints | 2024

Cromer D; Reynaldi A; Hie A; Schlub T; Juno J; Wheatley A; Kent S; Khoury D; Davenport M, 2024, Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates, http://dx.doi.org/10.1101/2024.02.08.24302032

Preprints | 2024

Hao T; Ryan GE; Lydeamore MJ; Cromer D; Wood J; McVernon J; McCaw JM; Shearer FM; Golding N, 2024, Predicting immune protection against outcomes of infectious disease from population-level effectiveness data with application to COVID-19, http://dx.doi.org/10.1101/2024.10.17.24314397

Preprints | 2023

Elias K; Khan S; Stadler E; Schlub T; Cromer D; Polizzotto M; Kent S; Turner T; Davenport M; Khoury D, 2023, Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: A systematic review and meta-analysis, http://dx.doi.org/10.1101/2023.06.18.23291566

Preprints | 2023

Le T; Conway E; Akpan E; Abell I; Abraham P; Baker C; Campbell P; Cromer D; Lydeamore M; McDonough Y; Mueller I; Ryan G; Walker C; Wang Y; Carvalho N; McVernon J, 2023, Cost-effective boosting allocations in the post-Omicron era of COVID-19 management, http://dx.doi.org/10.1101/2023.11.14.23298536

Preprints | 2023

Lee WS; Tan H-X; Reynaldi A; Esterbauer R; Koutsakos M; Nguyen J; Amarasena T; Kent H; Aggarwal A; Turville S; Taiaroa G; Kinsella P; Liew KC; Tran T; Williamson D; Cromer D; Davenport M; Kent S; Juno J; Khoury D; Wheatley A, 2023, Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection, , http://dx.doi.org/10.1101/2023.02.19.23286159

Preprints | 2023

Selva KJ; Ramanathan P; Haycroft ER; Reynaldi A; Cromer D; Tan CW; Wang L-F; Wines B; Hogarth M; Downie L; Davis S; Purcell RA; Kent H; Juno J; Wheatley A; Davenport M; Kent SJ; Chung A, 2023, Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough, http://dx.doi.org/10.1101/2023.03.28.23287848

Preprints | 2022

Cromer D; Steain M; Reynaldi A; Schlub T; Sasson S; Kent S; Khoury D; Davenport MP, 2022, Neutralising antibodies predict protection from severe COVID-19, http://dx.doi.org/10.1101/2022.06.09.22275942

Conference Posters | 2022

Docken S; McCormick K; Pampena M; Pinkevych M; Viox E; Keele B; Paiardini M; Betts M; Bar K; Davenport M; Samer S; Cromer D; Schlub T, 2022, 'PP 2.3 – 00034 CD8+ T-Cell Sieving During SIV Reactivation from Latency', Vol. 8, pp. 100159 - 100159, http://dx.doi.org/10.1016/j.jve.2022.100159

Preprints | 2022

Khoury D; Docken S; Subbarao K; Kent S; Davenport M; Cromer D, 2022, Predicting the efficacy of variant-modified COVID-19 vaccine boosters, http://dx.doi.org/10.1101/2022.08.25.22279237

Preprints | 2022

Khoury D; Schlub T; Cromer D; Steain M; Fong Y; Gilbert P; Subbarao K; Triccas J; Kent S; Davenport M, 2022, Correlates of protection, thresholds of protection, and immunobridging in SARS-CoV-2 infection, http://dx.doi.org/10.1101/2022.06.05.22275943

Conference Papers | 2022

Lau JSY; Cromer D; Pinkevych M; Lewin SR; Rasmussen TA; McMahon JH; Davenport MP, 2022, 'Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design', in Journal of Infectious Diseases, pp. 236 - 245, http://dx.doi.org/10.1093/infdis/jiac032

Preprints | 2022

Stadler E; Burgess M; Schlub T; Chai KL; McQuilten Z; Wood E; Polizzotto M; Kent S; Cromer D; Davenport M; Khoury D, 2022, Monoclonal antibody levels and protection from COVID-19, http://dx.doi.org/10.1101/2022.11.22.22282199

Preprints | 2022

Stadler E; Chai KL; Schlub T; Cromer D; Polizzotto M; Kent S; Beecher C; White H; White H; Turner T; Skoetz N; Skoetz N; Estcourt L; McQuilten Z; Wood E; Khoury D; Davenport M, 2022, Determinants of passive antibody efficacy in SARS-CoV-2 infection, http://dx.doi.org/10.1101/2022.03.21.22272672

Preprints | 2022

Stadler E; Cromer D; Mehra S; Adekunle A; Flegg J; Anstey N; Watson J; Chu C; Mueller I; Robinson L; Schlub T; Davenport M; Khoury D, 2022, Risk of Plasmodium vivax recurrences follows a 30-70 rule and indicates relapse heterogeneity in the population, http://dx.doi.org/10.1101/2022.05.18.22275180

Preprints | 2022

Stadler E; Cromer D; Ogunlade S; Ongoiba A; Doumbo S; Kayentao K; Traore B; Crompton P; Portugal S; Davenport M; Khoury D, 2022, A role for super-spreaders in carrying malaria parasites across the months-long dry season, http://dx.doi.org/10.1101/2022.04.28.22274398

Preprints | 2021

Aggarwal A; Stella AO; Walker G; Akerman A; Milogiannakis V; Brilot F; Amatayakul-Chantler S; Roth N; Coppola G; Schofield P; Jackson J; Henry J; Mazigi O; Langley D; Lu Y; Forster C; McAllery S; Mathivanan V; Fichter C; Hoppe AC; Munier ML; Jack H-M; Cromer D; Darley D; Matthews G; Christ D; Khoury D; Davenport M; Rawlinson W; Kelleher A; Turville S, 2021, SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, http://dx.doi.org/10.1101/2021.12.14.21267772

Preprints | 2021

Khoury D; Steain M; Triccas J; Sigal A; Davenport M; Cromer D, 2021, A meta-analysis of Early Results to predict Vaccine efficacy against Omicron, http://dx.doi.org/10.1101/2021.12.13.21267748

Preprints | 2021

Koutsakos M; Lee WS; Reynaldi A; Tan H-X; Gare G; Kinsella P; Liew KC; Williamson D; Kent H; Stadler E; Cromer D; Khoury D; Wheatley A; Juno J; Davenport M; Kent S, 2021, Dynamics of immune recall following SARS-CoV-2 vaccination or breakthrough infection, http://dx.doi.org/10.1101/2021.12.23.21268285

Conference Abstracts | 2021

Lansink LIM; Engel JA; Lee HJ; Soon MSF; Williams CG; Aogo RA; Cromer D; Davenport MP; Khoury DS; Haque A, 2021, 'Exposure to host inflammation in vivo induces rapid transcriptomic change and impaired maturation in malaria parasites', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 206, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713665801305&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2020

Lee WS; Selva KJ; Davis S; Wines B; Reynaldi A; Esterbauer R; Kelly H; Haycroft E; Tan H-X; Juno J; Wheatley A; Hogarth M; Cromer D; Davenport M; Chung A; Kent S, 2020, Decay of Fc-dependent antibody functions after mild to moderate COVID-19, http://dx.doi.org/10.1101/2020.12.13.20248143

Preprints | 2020

Price D; Shearer F; Meehan M; McBryde E; Moss R; Golding N; Conway E; Dawson P; Cromer D; Wood J; Abbott S; McVernon J; McCaw J, 2020, Early analysis of the Australian COVID-19 epidemic, http://dx.doi.org/10.1101/2020.04.25.20080127

Preprints | 2020

Wheatley A; Juno J; Wang J; Selva K; Reynaldi A; Tan H-X; Shi Lee W; Wragg K; Kelly H; Esterbauer R; Davis S; Kent H; Mordant F; Schlub T; Gordon D; Khoury D; Subbarao K; Cromer D; Gordon T; Chung A; Davenport M; Kent S, 2020, Evolution of immunity to SARS-CoV-2, http://dx.doi.org/10.1101/2020.09.09.20191205

Preprints | 2017

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection, , http://dx.doi.org/10.48550/arxiv.1701.05302

Investigator Grant (EL1: 2020-2024, EL2: 2025-2029)
ARC Discovery Grant (2018-2020)
NHMRC Project Grant (2015-2017)
NHMRC Project Grant (2012-2014)
ARC Discovery Grant (2012-2014)

Australian Museum Eureka Prize Finalist (2016 and 2023)
Young Tall Poppy Science Award (2015)
Aileen Plant Memorial Prize in Infectious Diseases Epidemiology (2015)
Vice Chancellor's Post Doctoral Research Fellowship (2010 - 2014)

Research Interests:
I am interested in the application of mathematical models to understanding infectious diseases both from an epidemiological perspective and as well as a within host perspective. My research includes understand COVID-19 epidemiology and immunology, the dynamics of HIV reactivation during and after antiretroviral therapy and the effects of vaccination on respiratory viruses. I have investigated the spread of mumps, rotavirus and influenza and the impact of vaccination against these common diseases.

Broad Research Areas:
Mathematical Biology and Modelling, Infectious Diseases, Epidemiology, Immunological Modelling

I am passionate about encouraging girls and women to explore their passion for mathematics. I regularly present the applications of my mathematical research at schools and in public forums.

Selection of Current and Past Society Memberships & Professional Activities:
Member of the Kirby institute Executive Committee
Executive Committee Member of the Women in Mathematics Special Interest Group of the Australian Mathematical Society
Executive Committee Member of the Mathematical Biology Special Interest Group of the Australian and New Zealand Industrial and Applied Mathematics Society (ANZIAM)
Member of Australasian Society for Immunology, Society for Mathematical Biology, Australian Mathematical Society, Australia and New Zealand Industrial and Applied Mathematics Society, Australian Society of Parasitology

My Research Supervision

I am currently supervising PhD, Masters and Honours students modelling infectious diseases. Projects apply mathematical techniques to understand COVID-19, HIV and other infectious diseases.

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Associate Professor Deborah Cromer