Conjoint Lecturer

Dr Etienne Farquhar

2015 PhB Science

2015 Hons (1st Class)

2021 PhD (UNSW Dean's Award)

Medicine & Health
School of Clinical Medicine

Dr Etienne Masle-Farquhar is a Research Officer (postdoctoral scientist) at the Garvan Institute of Medical Research, with A/Prof Owen Siggs and Prof Chris Goodnow, and a Conjoint Lecturer at St Vincent's School of Clinical Medicine, UNSW Medicine & Health.

Etienne co-leads the Exceptional Responders in Autoimmune/Inflammatory Diseases (ERAD) program.

Etienne completed Hons (First Class) with A/Prof Anselm Enders and Prof Stefan Broer at the John Curtin School of Medical Research (ANU, Canberra) and completed his PhD (UNSW Dean's Award for Outstanding PhD Thesis) with Prof Chris Goodnow and A/Prof Joanne Reed at the Garvan Institute.

Supported by the Garvan ERAD and HOPE programs, Etienne leads several projects utilising multi-omics and genomics to reveal mechanisms and improve treatments for autoimmune and autoinflammatory diseases.

Location
Garvan Institute of Medical Research
  • Journal articles | 2022
    Ho WHJ; Law AMK; Masle-Farquhar E; Castillo LE; Mawson A; O’Bryan MK; Goodnow CC; Gallego-Ortega D; Oakes SR; Ormandy CJ, 2022, 'Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases', Breast Cancer Research, 24, http://dx.doi.org/10.1186/s13058-022-01525-z
    Journal articles | 2022
    Masle-Farquhar E; Jackson KJL; Peters TJ; Al-Eryani G; Singh M; Payne KJ; Rao G; Avery DT; Apps G; Kingham J; Jara CJ; Skvortsova K; Swarbrick A; Ma CS; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O'Sullivan M; Cooper MA; Seppänen MRJ; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, 2022, 'STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation', Immunity, 55, pp. 2386 - 2404.e8, http://dx.doi.org/10.1016/j.immuni.2022.11.001
    Journal articles | 2021
    Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow CC, 2021, 'Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0237830
    Journal articles | 2020
    Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
    Journal articles | 2019
    Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, 35, pp. 297 - 314.e8, http://dx.doi.org/10.1016/j.ccell.2019.01.004
    Journal articles | 2017
    Burnett DL; Parish IA; Masle-Farquhar E; Brink R; Goodnow CC, 2017, 'Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation', Immunology and Cell Biology, 95, pp. 775 - 788, http://dx.doi.org/10.1038/icb.2017.50
    Journal articles | 2017
    Masle-Farquhar E; Broer A; Yabas M; Enders A; Broer S, 2017, 'ASCT2 (SLC1A5)-Deficient Mice Have Normal B-cells Developments, proliferation, and Antibody Production', FRONTIERS IN IMMUNOLOGY, 8, http://dx.doi.org/10.3389/fimmu.2017.00549
  • Preprints | 2022
    Masle-Farquhar E; Jackson KJL; Peters T; Al-Eryani G; Singh M; Payne K; Rao G; Apps G; Kingham J; Jara C; Skvortsova K; Swarbrick A; Ma C; Suan D; Uzel G; Chua I; Leiding J; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper M; Seppänen MRJ; Mustjoki S; Brothers S; Vogel T; Brink R; Tangye S; Reed J; Goodnow C, 2022, STAT3gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2DhiCD8 killer T cells, , http://dx.doi.org/10.1101/2022.02.11.480027
    Preprints | 2021
    Masle-Farquhar E; Peters T; Jackson KJL; Singh M; Ma C; Suan D; Uzel G; Chua I; Leiding J; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper M; Seppänen MRJ; Mustjoki S; Brothers S; Vogel T; Brink R; Tangye S; Reed J; Goodnow C, 2021, Overactive STAT3 drives accumulation of disease-associated CD21lowB cells, , http://dx.doi.org/10.1101/2021.12.20.473595
    Preprints | 2021
    Masle-Farquhar E; Peters T; Miosge L; Parish I; Weigel C; Oakes C; Reed J; Goodnow C, 2021, Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint, , http://dx.doi.org/10.1101/2021.07.01.450650
    Preprints | 2020
    Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow C, 2020, Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice, , http://dx.doi.org/10.1101/2020.08.05.237545

2022: Triple I Sphere Grant: 'Elucidating Cellular and Molecular drivers of Rheumatoid Arthritis disease flares'

2022: Equity Trustees Funding: 'Rheumatoid and Psoriatic Arthritis Project'

2021: Millenium Science Spatial Pioneers Fellowship: 'Spatial transcriptomics to elucidate mechanisms driving Inclusion Body Myositis'

2018-ongoing: Philanthropic support (Inclusion Body Myositis; Rheumatoid Arthritis; Systemic Sclerosis).

 

2023: Publication of the Quarter, UNSW St Vincent's Clinical School; Travel Award, Federation of Clinical Immunology Societies (FOCIS) Annual General Meeting, Boston, USA.

2022:  Triple I Sphere Grant to study Rheumatoid Arthris Flares; ICIS-Pfizer Junior Investigator Award; Travel Award for the B cell-T cell Keystone 2022, Hannover, Germany; Travel Award for the ASI Annual General Meeting, Melbourne, Australia.

2021:  Dean’s Award for Outstanding Thesis, UNSW, Sydney; Oral Presentation Prize, Federation of Immunological Societies of Asia-Oceania (FIMSA), FIMSA Annual Meeting, Seoul, Korea; Travel Award, FIMSA Annual Meeting 2021, Seoul, Korea; Best Postdoc Oral Presentation, St Vincent’s Campus Postdoc Symposium, Sydney, Australia.

2020:  Best Student Oral Presentation, St Vincent’s Campus Research Symposium, Sydney, Australia.

2019:  Travel Award, 2nd Human & Translational Immunology Conference, Kos Island, Greece; Travel Award, 2019 ThymE Conference, Weizmann Institute of Science, Rehovot, Israel; Travel Award, World Congress on Inflammation, Sydney, Australia.

2018:  Stuart Furler Travel Award, Garvan Institute of Medical Research; Travel Award, Australian and New Zealand Society of Immunology (ASI) Annual Scientific Meeting.

2017:  Shortlist for 2017 Writing NSW Writer & Scientist Grant, “Is winter coming? Immunology as a game of thrones”; 3rd place, 3 Minute Thesis (3MT), Garvan Institute of Medical Research.

2016:  Australian Postgraduate Award (APA) scholarship, for full duration of PhD undertaken at the Garvan Institute of Medical Research; Chancellor’s Letter of Commendation for Outstanding Academic Performance in 2015, Australian National University, Canberra.

2015:  Awarded the Alexander McTaggart Memorial Scholarship, Australian National University, Canberra, Australia.

2011:  French Baccalauréat Mention Très Bien (equivalent ATAR: 98).

2009: "Dux" of Telopea Park School, Canberra, Australia: Best Overall Academic Performance over the course of Secondary Education.

Etienne studies the molecular and cellular mechanisms by which germline and particularly somatic (=acquired) mutations drive immune-mediated diseases, with a specific focus on autoimmune disease and autoinflammatory diseases. This research is primarily performed directly on blood and affected tissue samples from patients, with the aim to identify gene, protein and cellular pathways driving clinical pathology - which may be therapeutically targeted to benefit patients.

Specific projects include: rheumatoid and psoriatic arthritis, gout, VEXAS, inclusion body myositis, atherosclerotic heart disease.

Student or research assistant applications are welcomed.

My Research Supervision

Co-primary supervisor: Honours student x 2.

Co-primary supervisor: Undergraduate student x 1.

Secondary supervisor: PhD student x 1.

Direct line manager: Research Assistant x 1.

Co-manager: Clinical Trials Coordinator x 1.