Conjoint Lecturer

Dr Etienne Farquhar

PhB Science; Hons (1st Class); PhD

Medicine & Health
School of Clinical Medicine

Etienne is a Research Officer (postdoctoral scientist) at the Garvan Institute of Medical Research, and a Conjoint Lecturer at St Vincent's School of Clinical Medicine, UNSW Medicine & Health.

Etienne completed Hons (First Class) with A/Prof Anselm Enders and Prof Stefan Broer at the John Curtin School of Medical Research (ANU, Canberra) and completed his PhD (awarded the UNSW Dean's Award for Outstanding PhD Thesis) with Prof Chris Goodnow and A/Prof Joanne Reed at the Garvan Institute. Etienne currently leads several projects relating to multi-omic study of mutant leukocytes driving autoimmune and autoinflammatory diseases, in his postdoctoral role with A/Prof Owen Siggs and Prof Chris Goodnow at the Garvan Institute.

Location
Garvan Institute of Medical Research
  • Journal articles | 2022
    Ho WHJ; Law AMK; Masle-Farquhar E; Castillo LE; Mawson A; O’Bryan MK; Goodnow CC; Gallego-Ortega D; Oakes SR; Ormandy CJ, 2022, 'Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases', Breast Cancer Research, vol. 24, pp. 31, http://dx.doi.org/10.1186/s13058-022-01525-z
    Journal articles | 2021
    Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow CC, 2021, 'Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice', PLoS ONE, vol. 16, pp. e0237830, http://dx.doi.org/10.1371/journal.pone.0237830
    Journal articles | 2020
    Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, vol. 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
    Journal articles | 2019
    Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, vol. 35, pp. 297 - 314.e8, http://dx.doi.org/10.1016/j.ccell.2019.01.004
    Journal articles | 2017
    Burnett DL; Parish IA; Masle-Farquhar E; Brink R; Goodnow CC, 2017, 'Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation', Immunology and Cell Biology, vol. 95, pp. 775 - 788, http://dx.doi.org/10.1038/icb.2017.50
    Journal articles | 2017
    Masle-Farquhar E; Broer A; Yabas M; Enders A; Broer S, 2017, 'ASCT2 (SLC1A5)-Deficient Mice Have Normal B-cells Developments, proliferation, and Antibody Production', FRONTIERS IN IMMUNOLOGY, vol. 8, http://dx.doi.org/10.3389/fimmu.2017.00549
  • Preprints | 2022
    Masle-Farquhar E; Jackson KJL; Peters T; Al-Eryani G; Singh M; Payne K; Rao G; Apps G; Kingham J; Jara C; Skvortsova K; Swarbrick A; Ma C; Suan D; Uzel G; Chua I; Leiding J; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper M; Seppänen MRJ; Mustjoki S; Brothers S; Vogel T; Brink R; Tangye S; Reed J; Goodnow C, 2022, STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells, http://dx.doi.org/10.1101/2022.02.11.480027
    Preprints | 2021
    Masle-Farquhar E; Peters T; Jackson KJL; Singh M; Ma C; Suan D; Uzel G; Chua I; Leiding J; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper M; Seppänen MRJ; Mustjoki S; Brothers S; Vogel T; Brink R; Tangye S; Reed J; Goodnow C, 2021, Overactive STAT3 drives accumulation of disease-associated CD21low B cells, http://dx.doi.org/10.1101/2021.12.20.473595
    Preprints | 2021
    Masle-Farquhar E; Peters T; Miosge L; Parish I; Weigel C; Oakes C; Reed J; Goodnow C, 2021, Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint, http://dx.doi.org/10.1101/2021.07.01.450650
    Preprints | 2020
    Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow C, 2020, Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice, http://dx.doi.org/10.1101/2020.08.05.237545

2018-2022: Philanthropic support (Inclusion Body Myositis).

2021: Millenium Science Spatial Pioneers Fellowship.

2022:  ICIS-Pfizer Junior Investigator Award (USD$1250); Travel Award for the B cell-T cell Keystone 2022, Hannover, Germany (USD$1200).

2021:  Dean’s Award for Outstanding Thesis, UNSW, Sydney; Oral Presentation Prize, Federation of Immunological Societies of Asia-Oceania (FIMSA), FIMSA Annual Meeting, Seoul, Korea; Travel Award, FIMSA Annual Meeting 2021, Seoul, Korea (USD$150); Best Postdoc Oral Presentation, St Vincent’s Campus Postdoc Symposium, Sydney, Australia.

2020:  Best Student Oral Presentation, St Vincent’s Campus Research Symposium, Sydney, Australia.

2019:  Travel Award, 2nd Human & Translational Immunology Conference, Kos Island, Greece (EUR€1000); Travel Award, 2019 ThymE Conference, Weizmann Institute of Science, Rehovot, Israel (EUR€750); Travel Award, World Congress on Inflammation, Sydney, Australia (AUD$495).

2018:  Stuart Furler Travel Award, Garvan Institute of Medical Research (AUD$5,000); Travel Award, Australian and New Zealand Society of Immunology (ASI) Annual Scientific Meeting ($AUD750).

2017:  Shortlist for 2017 Writing NSW Writer & Scientist Grant, “Is winter coming? Immunology as a game of thrones”; 3rd place, 3 Minute Thesis (3MT), Garvan Institute of Medical Research.

2016:  Australian Postgraduate Award (APA) scholarship, for full duration of PhD undertaken at the Garvan Institute of Medical Research; Chancellor’s Letter of Commendation for Outstanding Academic Performance in 2015, Australian National University, Canberra.

2015:  Awarded the Alexander McTaggart Memorial Scholarship, Australian National University, Canberra, Australia.

2011:  French Baccalauréat Mention Très Bien (equivalent ATAR: 98).

2009: "Dux" of Telopea Park School, Canberra, Australia: Best Overall Academic Performance over the course of Secondary Education.

Etienne studies the molecular and cellular mechanisms by which germline and particularly somatic (acquired) mutations drive immune-mediated diseases, with a specific focus on autoimmune disease and autoinflammatory diseases. This research is primarily performed directly on blood and affected tissue samples from patients, with the aim to identify gene, protein and cellular pathways driving clinical pathology and that can be therapeutically targeted to benefit patients.

Specific projects include: rheumatoid arthritis, inclusion body myositis, clonal hematopoiesis, sporadic adult-onset autoinflammation or autoimmunity.

Student applications are welcome.