Professor Fabio Luciani
Professor

Professor Fabio Luciani

INSTITUTION AND LOCATION

DEGREE

 

 

Completion Date

 

FIELD OF STUDY

 

University of Bologna, Italy

 

Humboldt University, Berlin, Germany

 

University of New South Wales, Australia

 

University of New South Wales, Australia

Masters

 

Ph.D.

 

Post-doctoral

 

Research Fellow

06/2000

 

06/2006

 

06/2008

 

06/2009

Physics

 

Theoretical Biology

Biophysics

Theoretical Biology

 

Bioinformatics Immunology

Medicine & Health
School of Biomedical Sciences

I am a Professor in Systems Immunology and Machine Learning at the School of Medical Sciences at UNSW Sydney, and I am a visiting fellow at the Garvan Institute for Medical Research and at the Weill Cornell College of Medicine NY, USA. 

My research program uses a Systems Immunology approach to study of T cell responses with the ultimate goal to develop and new immunotherapies that can be used against incurable cancer and autoimmune diseases.  I am passionate about Immunology, and of discoveries that are rapidly translating into immunotherapies for uncurable disorders. To achieve this goal I have developed a systems immunology program, which is an interdisciplinary approach that combines experimental and computational analyses to translate new molecular and genomics discoveries to  transform current immunotherapies into successful, precise and accessible solutions for a broader community of individuals.

I have a strong focus on utilising single cell cutting edge technologies genomics and computational biology ML techniques to develop next-generation T cell immunotherapies for cancer and autoimmunity, where I lead discoveries that can then be translated into clinical intervention, such as predicting side effects, identifying new solutions for unmet clinical needs.

Our research group in Systems Immunology and Immunogenomics, is an interdisciplinary team with skills in Immunology, Mathematical Modelling, Statistics and Bioinformatics to study immune responses, specifically T cells. I have  over 140 peer-reviewed publications where I have made significant contributions describing landmark bioinformatic methods to combine single-cell transcriptome data with antigen receptor sequences, computational models for haplotype reconstruction of genomes from high throughput deep sequencing data. I developed statistical models that allow for the identification of the full distribution of mutating and recombining genomes from a highly diverse sample, as well as mathematical models that have contributed to the design of public health interventions to control viral infection in prison settings. I have also developed experimental techniques for identification of antigen specific T cells from blood samples and utilised high dimensional flow cytometry, mass cytometry, as well as functional assays.

The current major research focus of my laboratory is on the single-cell analyses of immune cells in the context of viral infections, autoimmunity and CAR T cells. I have successfully applied these techniques in autoimmune disease, viral infections and CAR T cells, and applied to both human and mouse samples. My lab has also developed single cell approaches to study rate populations of antigen specific immune cells isolated from cryopreserved human samples (blood or tissue) and developed novel bioinformatics methods to analyse these data to explore how T cell phenotypes and clonotypes change longitudinally over time in the same individual.

During my career I have been successful in obtaining research funds from public and private sector for a total of >20 millions. At UNSW Sydney, I am a Principal Investigator of a recently funded Institute, the UNSW Future Institute of Cellular Genomics, which has planned to invest US$ 4.5 Millions over the next 7 years to deliver cutting edge single cell technologies in cellular genomics. In the last three years, I have successfully obtained research funds from private sector (BD Bioscience) to lead a project on the application of single cell multi-omics to study CAR T cell therapies, and specifically from samples obtained from a clinical trial conducted in Sydney. In this project my laboratory has led the experimental and bioinformatics analyses.  My track record and skills provide evidence that I am capable to lead the data analyses and contribute to the experimental design in this project.

 

Research Interests

Systems Immunology 

  1. Immune Receptor analysis using Next generation Sequencing Our group is very much interested in the study of T and B cell receptors and how these highly specific proteins determine successful immune responses. We use statistics and bioinformatics to analyse immune receptor data generate din our lab and from collaborators. 
  2. Bioinformatics software We have experience in software tools to study pathogen genomics, immune cells and we also develop workflows for integrated analyses across genomic, immunological and clinical data sets.
  3. T cell responses in influenza virus   We are closely collaborating with professor Katherine Kedzierska (Peter Doherty Institute in Melbourne) on the study of T cell responses that arise during influenza virus infection using single cell genomics

Single Cell Genomics and Multi-Omics

  1. Analysis of single cell multiomics in the context of Coeliac disease. This project is a collaboration with Prof Chris Goodnow's team at the Garvan Institute.
  2. Understanding CAR T cell therapy response in the context of blood disorders and solid tumors. This is an exciting project in collaboration with clinicians at Westmead Hospital in Sydney, and also with Researchers at Weill Cornell in New York.
  3. Single cell isolation and Single cell transcriptomics. This is our new interest. We are studying how antigen speciifc T cells change their phenotype upon antigen encounter, and how these cells further develop into protective memory cells.

 

Phone
+61 (2) 9385 3838
Location
Lowy Buidling
  • Book Chapters | 2019
    Van Der Byl W; Rizzetto S; Samir J; Cai C; Eltahla AA; Luciani F, 2019, 'Single-Cell Transcriptome Analysis of T Cells', in Methods in Molecular Biology, pp. 155 - 205, http://dx.doi.org/10.1007/978-1-4939-9728-2_16
    Book Chapters | 2016
    Bull RA; Luciani F, 2016, 'Next-Generation Sequencing, What Has It Told Us So Far?', in Foodborne Viral Pathogens, CRC Press
    Book Chapters | 2008
    Mishto M; Luciani F; Holzhutter H; Bellavista E; Santoro A; Textoris-Taube K; Kloetzel P; Zaikin A; Franceschi C, 2008, 'ProteaMAlg: a Proteasome Modelling Algorithm to address the complexity of intracellular protein degradation kinetics.', in Gastone C; Lamberti E; Fortunati V; Franceschi C (ed.), Biocomplexity at the cutting edge of Physics, System Biology and Humanities, Bononia University Press, Bononia
    Book Chapters | 2007
    Luciani F; Nielsen M; Kesmir C; Di napoli M, 2007, 'Theoretical models for proteasome function: predictive methods to understand the ubiquitin protein system in neurodegenerative diseases. [Chapter on modelling proteasome degradation and of potential mechanisms behind the accumulation of proteins leading to neurodegenerative diseases, such as Huntington disease or Amyotrophic Lateral Sclerosis.]', in Napoli MD; Wojcik C (ed.), The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology, Nova Biomedical Books
    Book Chapters | 2007
    Zaikin A; Luciani F; Kurths J, 2007, 'Constructing a virtual proteasome', in Bertau M; Mosekilde E; Westerhoff HV (ed.), Biosimulation in Drug Development, Wiley-VCH Verlag GmbH & Co, Germany, pp. 373 - 402
    Book Chapters | 2006
    Luciani F; Zaikin A, 2006, 'Mathematical models of the proteasome product size distribution', in Schimansky-Geier L; Malchow H; Poeschel T (ed.), Irreversible Prozesse und Selbstorganisation, Logos-Verlag, Berlin, pp. 196 - 208
    Book Chapters | 2006
    Luciani F; Zaikin A, 2006, 'Mathematical models of the proteasome product size', in Schimansky Geier L; Malchow H; Poeschel T (ed.), Irreversible Prozesse und Selbstorganisation, Logos-Verlag, Berlin, pp. 279 - 292
  • Journal articles | 2023
    Ghita L; Yao Z; Xie Y; Duran V; Cagirici HB; Samir J; Osman I; Rebellón-Sánchez DE; Agudelo-Rojas OL; Sanz AM; Sahoo MK; Robinson ML; Gelvez-Ramirez RM; Bueno N; Luciani F; Pinsky BA; Montoya JG; Estupiñan-Cardenas MI; Villar-Centeno LA; Rojas-Garrido EM; Rosso F; Quake SR; Zanini F; Einav S, 2023, 'Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach', Nature Immunology, 24, pp. 2150 - 2163, http://dx.doi.org/10.1038/s41590-023-01654-3
    Journal articles | 2023
    Gupta M; Balachandran H; Louie RHY; Li H; Agapiou D; Keoshkerian E; Christ D; Rawlinson W; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Bartlett AW; Sasson SC; Ahlenstiel G; Dwyer D; Lloyd AR; Martinello M; Luciani F; Bull RA, 2023, 'High activation levels maintained in receptor-binding domain–specific memory B cells in people with severe coronavirus disease 2019', Immunology and Cell Biology, 101, pp. 142 - 155, http://dx.doi.org/10.1111/imcb.12607
    Journal articles | 2023
    Louie RHY; Cai C; Samir J; Singh M; Deveson IW; Ferguson JM; Amos TG; McGuire HM; Gowrishankar K; Adikari T; Balderas R; Bonomi M; Ruella M; Bishop D; Gottlieb D; Blyth E; Micklethwaite K; Luciani F, 2023, 'CAR+ and CAR T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-43656-7
    Journal articles | 2023
    Luciani F; Louie RY; Cai C; Singh M; Deveson I; Ferguson J; Amos T; McGuire H; Samir J; Gowrishankar K; Adikari T; Balderas R; Bishop D; Gottileb D; Blyth E; Micklethwaite K, 2023, 'CAR +and CAR −T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion', The Journal of Immunology, 210, pp. 159.15 - 159.15, http://dx.doi.org/10.4049/jimmunol.210.supp.159.15
    Journal articles | 2023
    Luciani F; Papa E; Leggeri A; Condò R; Giovannetti F; Calabrese L, 2023, 'Peripheral ameloblastoma: case report and our experience 20 years', Acta Biomedica, 94, http://dx.doi.org/10.23750/abm.v94iS1.13527
    Journal articles | 2023
    Melén E; Lambrecht BN; Lloyd CM; Rothenberg ME; Kabashima K; Luciani F; Coquet JM; Ober C; Nawijn MC; Platts-Mills T; von Mutius E, 2023, 'A conversation on allergy: recognizing the past and looking to the future', Immunology and Cell Biology, 101, pp. 936 - 946, http://dx.doi.org/10.1111/imcb.12688
    Journal articles | 2023
    Shek D; Gao B; Mahajan H; Nagrial A; Carlino MS; Luciani F; Read SA; Ahlenstiel G, 2023, 'In-depth profiling of tumor tissue derived from malignant pleural mesothelioma patients identifies potential biomarkers predicting response to immune-checkpoint inhibitor therapy', Genes & Diseases, pp. 101189 - 101189, http://dx.doi.org/10.1016/j.gendis.2023.101189
    Journal articles | 2023
    Underwood AP; Gupta M; Wu B-R; Eltahla AA; Boo I; Wang JJ; Agapiou D; Abayasingam A; Reynaldi A; Keoshkerian E; Zhao Y; Brasher N; Walker MR; Bukh J; Maher L; Gordon T; Davenport M; Luciani F; Drummer HE; Lloyd AR; Bull RA, 2023, 'B Cell Signatures and Antibody Imprinting Define HCV Reinfection Outcome', , http://dx.doi.org/10.2139/ssrn.4418620
    Journal articles | 2023
    Yang Y; Louie R; Puc J; Vedvyas Y; Alcaina Y; Min IM; Britz M; Luciani F; Jin MM, 2023, 'Abstract 912: Single cell analysis reveals tumor evolution and CAR T cell dysfunction associated with tumor resistance', Cancer Research, 83, pp. 912 - 912, http://dx.doi.org/10.1158/1538-7445.am2023-912
    Journal articles | 2023
    Yang Y; Louie R; Puc J; Vedvyas Y; Alcaina Y; Min IM; Britz M; Luciani F; Jin MM, 2023, 'Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance', Cancers, 15, http://dx.doi.org/10.3390/cancers15235552
    Journal articles | 2023
    van de Sandt CE; Nguyen THO; Gherardin NA; Crawford JC; Samir J; Minervina AA; Pogorelyy MV; Rizzetto S; Szeto C; Kaur J; Ranson N; Sonda S; Harper A; Redmond SJ; McQuilten HA; Menon T; Sant S; Jia X; Pedrina K; Karapanagiotidis T; Cain N; Nicholson S; Chen Z; Lim R; Clemens EB; Eltahla A; La Gruta NL; Crowe J; Lappas M; Rossjohn J; Godfrey DI; Thomas PG; Gras S; Flanagan KL; Luciani F; Kedzierska K, 2023, 'Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan', Nature Immunology, 24, pp. 1890 - 1907, http://dx.doi.org/10.1038/s41590-023-01633-8
    Journal articles | 2022
    Cai C; Samir J; Adikari T; Peters T; Luciani F, 2022, 'The functional and molecular determinants of HCV-specific CD8 T cell responses during early infection', The Journal of Immunology, 208, pp. 169.12 - 169.12, http://dx.doi.org/10.4049/jimmunol.208.supp.169.12
    Journal articles | 2022
    Cai C; Samir J; Pirozyan MR; Adikari TN; Gupta M; Leung P; Hughes B; Van der Byl W; Rizzetto S; Elthala A; Keoshkerian E; Palgen JL; Peters T; Nguyen THO; Louie R; Kedzierska K; Gaudieri S; Bull RA; Lloyd AR; Luciani F, 2022, 'Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-35281-7
    Journal articles | 2022
    Goncharov M; Bagaev D; Shcherbinin D; Zvyagin I; Bolotin D; Thomas PG; Minervina AA; Pogorelyy MV; Ladell K; McLaren JE; Price DA; Nguyen THO; Rowntree LC; Clemens EB; Kedzierska K; Dolton G; Rius CR; Sewell A; Samir J; Luciani F; Zornikova KV; Khmelevskaya AA; Sheetikov SA; Efimov GA; Chudakov D; Shugay M, 2022, 'VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2', Nature Methods, http://dx.doi.org/10.1038/s41592-022-01578-0
    Journal articles | 2022
    Luciani F; Papa E; Leggeri A; Calabrese C; Coniglione F; Calabrese L, 2022, 'DIAGNOSIS AND TREATMENT PLANNING IN ORAL SURGERY USING CONE BEAM COMPUTED TOMOGRAPHY (CBCT): A NARRATIVE REVIEW', International Journal of Clinical Dentistry, 15, pp. 795 - 820
    Journal articles | 2022
    Massey J; Jackson K; Singh M; Hughes B; Withers B; Ford C; Khoo M; Hendrawan K; Zaunders J; Charmeteau-De Muylder B; Cheynier R; Luciani F; Ma D; Moore J; Sutton I, 2022, 'Haematopoietic Stem Cell Transplantation Results in Extensive Remodelling of the Clonal T Cell Repertoire in Multiple Sclerosis', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.798300
    Journal articles | 2021
    Foster S; Luciani F, 2021, 'Omics in immunology', Immunology and Cell Biology, 99, pp. 133 - 134, http://dx.doi.org/10.1111/imcb.12435
    Journal articles | 2021
    González-Candelas F; Shaw MA; Phan T; Kulkarni-Kale U; Paraskevis D; Luciani F; Kimura H; Sironi M, 2021, 'One year into the pandemic: Short-term evolution of SARS-CoV-2 and emergence of new lineages', Infection, Genetics and Evolution, 92, http://dx.doi.org/10.1016/j.meegid.2021.104869
    Journal articles | 2021
    Gottlieb DJ; Clancy LE; Withers B; McGuire HM; Luciani F; Singh M; Hughes B; Gloss B; Kliman D; Ma CKK; Panicker S; Bishop D; Dubosq MC; Li Z; Avdic S; Micklethwaite K; Blyth E, 2021, 'Prophylactic antigen-specific T-cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant', Clinical and Translational Immunology, 10, http://dx.doi.org/10.1002/cti2.1249
    Journal articles | 2021
    Hensen L; Illing PT; Bridie Clemens E; Nguyen THO; Koutsakos M; van de Sandt CE; Mifsud NA; Nguyen AT; Szeto C; Chua BY; Halim H; Rizzetto S; Luciani F; Loh L; Grant EJ; Saunders PM; Brooks AG; Rockman S; Kotsimbos TC; Cheng AC; Richards M; Westall GP; Wakim LM; Loudovaris T; Mannering SI; Elliott M; Tangye SG; Jackson DC; Flanagan KL; Rossjohn J; Gras S; Davies J; Miller A; Tong SYC; Purcell AW; Kedzierska K, 2021, 'CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-23212-x
    Journal articles | 2021
    Kwon JA; Chambers GM; Luciani F; Zhang L; Kinathil S; Kim D; Thein HH; Botha W; Thompson S; Lloyd A; Yap L; Gray RT; Butler T, 2021, 'Hepatitis C treatment strategies in prisons: A cost-effectiveness analysis', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0245896
    Journal articles | 2021
    Lim CS; Sozzi V; Littlejohn M; Yuen LKW; Warner N; Betz-Stablein B; Luciani F; Revill PA; Brown CM, 2021, 'Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes', Microbial Genomics, 7, pp. 1 - 13, http://dx.doi.org/10.1099/mgen.0.000492
    Journal articles | 2021
    Louie RHY; Luciani F, 2021, 'Recent advances in single-cell multimodal analysis to study immune cells', Immunology and Cell Biology, 99, pp. 157 - 167, http://dx.doi.org/10.1111/imcb.12432
    Journal articles | 2021
    Micklethwaite KP; Gowrishankar K; Gloss BS; Li Z; Street JA; Moezzi L; Mach MA; Sutrave G; Clancy LE; Bishop DC; Louie RHY; Cai C; Foox J; MacKay M; Sedlazeck FJ; Blombery P; Mason CE; Luciani F; Gottlieb DJ; Blyth E, 2021, 'Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells', Blood, 138, pp. 1391 - 1405, http://dx.doi.org/10.1182/blood.2021010858
    Journal articles | 2021
    Sullivan LC; Nguyen THO; Harpur CM; Stankovic S; Kanagarajah AR; Koutsakos M; Saunders PM; Cai Z; Gray JA; Widjaja JML; Lin J; Pietra G; Mingari MC; Moretta L; Samir J; Luciani F; Westall GP; Malmberg KJ; Kedzierska K; Brooks AG, 2021, 'Natural killer cell receptors regulate responses of HLA-E-restricted T cells', Science Immunology, 6, http://dx.doi.org/10.1126/sciimmunol.abe9057
    Journal articles | 2021
    Sutton HJ; Aye R; Idris AH; Vistein R; Nduati E; Kai O; Mwacharo J; Li X; Gao X; Andrews TD; Koutsakos M; Nguyen THO; Nekrasov M; Milburn P; Eltahla A; Berry AA; KC N; Chakravarty S; Sim BKL; Wheatley AK; Kent SJ; Hoffman SL; Lyke KE; Bejon P; Luciani F; Kedzierska K; Seder RA; Ndungu FM; Cockburn IA, 2021, 'Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans', Cell Reports, 34, http://dx.doi.org/10.1016/j.celrep.2020.108684
    Journal articles | 2021
    Wagle MV; Vervoort SJ; Kelly MJ; Van Der Byl W; Peters TJ; Martin BP; Martelotto LG; Nüssing S; Ramsbottom KM; Torpy JR; Knight D; Reading S; Thia K; Miosge LA; Howard DR; Gloury R; Gabriel SS; Utzschneider DT; Oliaro J; Powell JD; Luciani F; Trapani JA; Johnstone RW; Kallies A; Goodnow CC; Parish IA, 2021, 'Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-23044-9
    Journal articles | 2021
    Zhao Y; Cai C; Samir J; Palgen JL; Keoshkerian E; Li H; Bull RA; Luciani F; An H; Lloyd AR, 2021, 'Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3', European Journal of Immunology, 51, pp. 1732 - 1747, http://dx.doi.org/10.1002/eji.202049057
    Journal articles | 2020
    Adikari TN; Di Giallonardo F; Leung P; Grifoni A; Sette A; Weiskopf D; Bull RA; Luciani F, 2020, 'Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-77565-2
    Journal articles | 2020
    Adikari TN; Riaz N; Sigera C; Leung P; Valencia BM; Barton K; Smith MA; Bull RA; Li H; Luciani F; Weeratunga P; Thein TL; Lim VWX; Leo YS; Rajapakse S; Fink K; Lloyd AR; Fernando D; Rodrigo C, 2020, 'Single molecule, near full-length genome sequencing of dengue virus', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-75374-1
    Journal articles | 2020
    Bagaev DV; Vroomans RMA; Samir J; Stervbo U; Rius C; Dolton G; Greenshields-Watson A; Attaf M; Egorov ES; Zvyagin IV; Babel N; Cole DK; Godkin AJ; Sewell AK; Kesmir C; Chudakov DM; Luciani F; Shugay M, 2020, 'VDJdb in 2019: Database extension, new analysis infrastructure and a T-cell receptor motif compendium', Nucleic Acids Research, 48, pp. D1057 - D1062, http://dx.doi.org/10.1093/nar/gkz874
    Journal articles | 2020
    Brasher NA; Eltahla AA; Underwood A; Boo I; Rizzetto S; Walker MR; Rodrigo C; Luciani F; Maher L; Drummer HE; Tedla N; Lloyd AR; Bull RA, 2020, 'B cell immunodominance in primary hepatitis C virus infection', Journal of Hepatology, 72, pp. 670 - 679, http://dx.doi.org/10.1016/j.jhep.2019.11.011
    Journal articles | 2020
    Bretaña NA; Gray RR; Cunningham EB; Betz-Stablein B; Ribeiro R; Graw F; Luciani F; Lloyd AR, 2020, 'Combined treatment and prevention strategies for hepatitis C virus elimination in the prisons in New South Wales: a modelling study', Addiction, 115, pp. 901 - 913, http://dx.doi.org/10.1111/add.14830
    Journal articles | 2020
    Bull RA; Adikari TN; Ferguson JM; Hammond JM; Stevanovski I; Beukers AG; Naing Z; Yeang M; Verich A; Gamaarachchi H; Kim KW; Luciani F; Stelzer-Braid S; Eden JS; Rawlinson WD; van Hal SJ; Deveson IW, 2020, 'Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-20075-6
    Journal articles | 2020
    Castellano-González G; McGuire HM; Luciani F; Clancy LE; Li Z; Avdic S; Hughes B; Singh M; De St Groth BF; Renga G; Pariano M; Bellet MM; Romani L; Gottlieb DJ, 2020, 'Rapidly expanded partially HLA DRB1-matched fungus-specific T cells mediate in vitro and in vivo antifungal activity', Blood Advances, 4, pp. 3443 - 3456, http://dx.doi.org/10.1182/bloodadvances.2020001565
    Journal articles | 2020
    Lee KH; Gowrishankar K; Street J; McGuire HM; Luciani F; Hughes B; Singh M; Clancy LE; Gottlieb DJ; Micklethwaite KP; Blyth E, 2020, 'Ex vivo enrichment of PRAME antigen-specific T cells for adoptive immunotherapy using CD137 activation marker selection', Clinical and Translational Immunology, 9, http://dx.doi.org/10.1002/cti2.1200
    Journal articles | 2020
    Li H; Cameron B; Douglas D; Stapleton S; Cheguelman G; Butler T; Luciani F; Lloyd AR, 2020, 'Incident hepatitis B virus infection and immunisation uptake in Australian prison inmates', Vaccine, 38, pp. 3255 - 3260, http://dx.doi.org/10.1016/j.vaccine.2020.02.076
    Journal articles | 2020
    McGuire HM; Rizzetto S; Withers BP; Clancy LE; Avdic S; Stern L; Patrick E; Fazekas de St Groth B; Slobedman B; Gottlieb DJ; Luciani F; Blyth E, 2020, 'Mass cytometry reveals immune signatures associated with cytomegalovirus (CMV) control in recipients of allogeneic haemopoietic stem cell transplant and CMV-specific T cells', Clinical and Translational Immunology, 9, http://dx.doi.org/10.1002/cti2.1149
    Journal articles | 2020
    Niño JLG; Pageon SV; Tay SS; Colakoglu F; Kempe D; Hywood J; Mazalo JK; Cremasco J; Govendir MA; Dagley LF; Hsu K; Rizzetto S; Zieba J; Rice G; Prior V; O’neill G; Williams RJ; Nisbet DR; Kramer B; Webb AI; Luciani F; Read MN; Biro M, 2020, 'Cytotoxic T cells swarm by homotypic chemokine signalling', eLife, 9, pp. 1 - 71, http://dx.doi.org/10.7554/eLife.56554
    Journal articles | 2020
    Samir J; Rizzetto S; Gupta M; Luciani F, 2020, 'Exploring and analysing single cell multi-omics data with VDJView', BMC Medical Genomics, 13, http://dx.doi.org/10.1186/s12920-020-0696-z
    Journal articles | 2020
    Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
    Journal articles | 2020
    Sironi M; Hasnain SE; Rosenthal B; Phan T; Luciani F; Shaw MA; Sallum MA; Mirhashemi ME; Morand S; González-Candelas F, 2020, 'SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective', Infection, Genetics and Evolution, 84, http://dx.doi.org/10.1016/j.meegid.2020.104384
    Journal articles | 2019
    Abayasingam A; Leung P; Eltahla A; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Cox AL; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Lloyd A; Rodrigo C, 2019, 'Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing', Infection, Genetics and Evolution, 71, pp. 36 - 41, http://dx.doi.org/10.1016/j.meegid.2019.02.032
    Journal articles | 2019
    Keck ZY; Pierce BG; Lau P; Lu J; Wang Y; Underwood A; Bull RA; Prentoe J; Velázquez-Moctezuma R; Walker MR; Luciani F; Guest JD; Fauvelle C; Baumert TF; Bukh J; Lloyd AR; Foung SKH, 2019, 'Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design', PLoS Pathogens, 15, http://dx.doi.org/10.1371/journal.ppat.1007772
    Journal articles | 2019
    Kim KW; Horton JL; Pang CNI; Jain K; Leung P; Isaacs SR; Bull RA; Luciani F; Wilkins MR; Catteau J; Lipkin WI; Rawlinson WD; Briese T; Craig ME, 2019, 'Higher abundance of enterovirus A species in the gut of children with islet autoimmunity', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-018-38368-8
    Journal articles | 2019
    Koutsakos M; Illing PT; Nguyen THO; Mifsud NA; Crawford JC; Rizzetto S; Eltahla AA; Clemens EB; Sant S; Chua BY; Wong CY; Allen EK; Teng D; Dash P; Boyd DF; Grzelak L; Zeng W; Hurt AC; Barr I; Rockman S; Jackson DC; Kotsimbos TC; Cheng AC; Richards M; Westall GP; Loudovaris T; Mannering SI; Elliott M; Tangye SG; Wakim LM; Rossjohn J; Vijaykrishna D; Luciani F; Thomas PG; Gras S; Purcell AW; Kedzierska K, 2019, 'Human CD8 + T cell cross-reactivity across influenza A, B and C viruses', Nature Immunology, 20, pp. 613 - 625, http://dx.doi.org/10.1038/s41590-019-0320-6
    Journal articles | 2019
    Pirozyan MR; Nguyen N; Cameron B; Luciani F; Bull RA; Zekry A; Lloyd AR, 2019, 'Chemokine-Regulated Recruitment of Antigen-Specific T-Cell Subpopulations to the Liver in Acute and Chronic Hepatitis C Infection', Journal of Infectious Diseases, 219, pp. 1430 - 1438, http://dx.doi.org/10.1093/infdis/jiy679
    Journal articles | 2019
    Rodrigo C; Leung P; Lloyd AR; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Cox AL; Osburn W; Kim AY; Shoukry NH; Lauer GM; Maher L; Schinkel J; Prins M; Hellard M; Eltahla AA, 2019, 'Genomic variability of within-host hepatitis C variants in acute infection', Journal of Viral Hepatitis, 26, pp. 476 - 484, http://dx.doi.org/10.1111/jvh.13051
    Journal articles | 2019
    Rodrigo C; Luciani F, 2019, 'Dynamic interactions between RNA viruses and human hosts unravelled by a decade of next generation sequencing', Biochimica et Biophysica Acta - General Subjects, 1863, pp. 511 - 519, http://dx.doi.org/10.1016/j.bbagen.2018.12.003
    Journal articles | 2019
    Singh M; Al-Eryani G; Carswell S; Ferguson JM; Blackburn J; Barton K; Roden D; Luciani F; Giang Phan T; Junankar S; Jackson K; Goodnow CC; Smith MA; Swarbrick A, 2019, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11049-4
    Journal articles | 2019
    Walker MR; Leung P; Eltahla AA; Underwood A; Abayasingam A; Brasher NA; Li H; Wu BR; Maher L; Luciani F; Lloyd AR; Bull RA, 2019, 'Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-49454-w
    Journal articles | 2018
    Cunningham EB; Hajarizadeh B; Amin J; Bretana N; Dore GJ; Degenhardt L; Larney S; Luciani F; Lloyd AR; Grebely J, 2018, 'Longitudinal injecting risk behaviours among people with a history of injecting drug use in an Australian prison setting: The HITS-p study', International Journal of Drug Policy, 54, pp. 18 - 25, http://dx.doi.org/10.1016/j.drugpo.2017.12.013
    Journal articles | 2018
    Isaacs SR; Kim KW; Cheng JX; Bull RA; Stelzer-Braid S; Luciani F; Rawlinson WD; Craig ME, 2018, 'Amplification and next generation sequencing of near full-length human enteroviruses for identification and characterisation from clinical samples', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-30322-y
    Journal articles | 2018
    Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CML; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-05772-7
    Journal articles | 2018
    Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed JH; Cai CH; Lloyd AR; Eltahla AA; Goodnow CC; Luciani F, 2018, 'B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle', Bioinformatics, 34, pp. 2846 - 2847, http://dx.doi.org/10.1093/BIOINFORMATICS/BTY171
    Journal articles | 2018
    Shugay M; Bagaev DV; Zvyagin IV; Vroomans RM; Crawford JC; Dolton G; Komech EA; Sycheva AL; Koneva AE; Egorov ES; Eliseev AV; Van Dyk E; Dash P; Attaf M; Rius C; Ladell K; McLaren JE; Matthews KK; Clemens EB; Douek DC; Luciani F; Van Baarle D; Kedzierska K; Kesmir C; Thomas PG; Price DA; Sewell AK; Chudakov DM, 2018, 'VDJdb: A curated database of T-cell receptor sequences with known antigen specificity', Nucleic Acids Research, 46, pp. D419 - D427, http://dx.doi.org/10.1093/nar/gkx760
    Journal articles | 2018
    Singh M; Al-Eryani G; Carswell S; Ferguson J; Blackburn J; Barton K; Roden D; Luciani F; Phan T; Junankar S; Jackson K; Goodnow C; Smith M; Swarbrick A, 2018, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', , http://dx.doi.org/10.1101/424945
    Journal articles | 2018
    Stern L; McGuire H; Avdic S; Rizzetto S; Fazekas de St Groth B; Luciani F; Slobedman B; Blyth E, 2018, 'Mass Cytometry for the assessment of immune reconstitution after hematopoietic stem cell transplantation', Frontiers in Immunology, 9, http://dx.doi.org/10.3389/fimmu.2018.01672
    Journal articles | 2018
    Underwood AP; Walker MR; Brasher NA; Eltahla AA; Maher L; Luciani F; Lloyd AR; Bull RA, 2018, 'Understanding the determinants of BnAb induction in acute HCV infection', Viruses, 10, http://dx.doi.org/10.3390/v10110659
    Journal articles | 2018
    Wang Z; Zhu L; Nguyen THO; Wan Y; Sant S; Quiñones-Parra SM; Crawford JC; Eltahla AA; Rizzetto S; Bull RA; Qiu C; Koutsakos M; Clemens EB; Loh L; Chen T; Liu L; Cao P; Ren Y; Kedzierski L; Kotsimbos T; McCaw JM; La Gruta NL; Turner SJ; Cheng AC; Luciani F; Zhang X; Doherty PC; Thomas PG; Xu J; Kedzierska K, 2018, 'Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-03243-7
    Journal articles | 2017
    Cunningham E; Amin J; Bretana NA; Luciani F; Degenhardt L; Larney S; Hajarizadeh B; Dore GJ; Lloyd A; Grebely J, 2017, 'P10 Injecting risk behaviours among people who inject drugs in an Australian prison setting, 2005–2014: the HITS-p study', Journal of Virus Eradication, 3, pp. 15 - 16, http://dx.doi.org/10.1016/s2055-6640(20)30751-2
    Journal articles | 2017
    Cunningham EB; Hajarizadeh B; Bretana NA; Amin J; Betz-Stablein B; Dore GJ; Luciani F; Teutsch S; Dolan K; Lloyd AR; Grebely J; Haber P; Rawlinson W; Treloar C; Maher L, 2017, 'Ongoing incident hepatitis C virus infection among people with a history of injecting drug use in an Australian prison setting, 2005-2014: The HITS-p study', Journal of Viral Hepatitis, 24, pp. 733 - 741, http://dx.doi.org/10.1111/jvh.12701
    Journal articles | 2017
    Eltahla AA; Leung P; Pirozyan MR; Rodrigo C; Grebely J; Applegate T; Maher L; Luciani F; Lloyd AR; Bull RA, 2017, 'Dynamic evolution of hepatitis C virus resistance-associated substitutions in the absence of antiviral treatment', Scientific Reports, 7, http://dx.doi.org/10.1038/srep41719
    Journal articles | 2017
    Eltahla AA; Rodrigo C; Betz-Stablein B; Grebely J; Applegate T; Luciani F; Schinkel J; Dore GJ; Page K; Bruneau J; Morris MD; Cox AL; Kim AY; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Lloyd AR; Bull RA, 2017, 'Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents', Journal of Viral Hepatitis, 24, pp. 37 - 42, http://dx.doi.org/10.1111/jvh.12615
    Journal articles | 2017
    Leung P; Eltahla AA; Lloyd AR; Bull RA; Luciani F, 2017, 'Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity', Virus Research, 239, pp. 43 - 54, http://dx.doi.org/10.1016/j.virusres.2016.10.014
    Journal articles | 2017
    Luciani F; Paolantonio G; Calabrese C; Calabrese L, 2017, 'Cytology and molecular mechanisms of drug-induced gingival hypertrophy: A rewiew', ORAL and Implantology, 10, pp. 221 - 228, http://dx.doi.org/10.11138/orl/2017.10.3.221
    Journal articles | 2017
    Merani S; Lucas M; Deshpande P; Pfafferott K; Chopra A; Cooper D; Leary S; Luciani F; Gaudieri S, 2017, 'Influence of transmitted virus on the host's immune response: A case study', Viral Immunology, 30, pp. 533 - 541, http://dx.doi.org/10.1089/vim.2017.0001
    Journal articles | 2017
    Ottria L; Luciani F; Piva P; Alagna AM; Arcuri C; Bartuli FN, 2017, 'The flap recovery on the impacted lower third molar surgery comparing 3 different flap designs: A clinical study', ORAL and Implantology, 10, pp. 270 - 275, http://dx.doi.org/10.11138/orl/2017.10.3.270
    Journal articles | 2017
    Rizzetto S; Eltahla A; Lin P; Bull R; Lloyd A; Ho J; Venturi V; Luciani F, 2017, 'Impact of sequencing depth and read length on single cell RNA sequencing data: lessons from T cells', , http://dx.doi.org/10.1101/134130
    Journal articles | 2017
    Rizzetto S; Eltahla AA; Lin P; Bull R; Lloyd AR; Ho JWK; Venturi V; Luciani F, 2017, 'Impact of sequencing depth and read length on single cell RNA sequencing data of T cells', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-12989-x
    Journal articles | 2017
    Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed J; Cai C; Lloyd A; Eltahla A; Goodnow C; Luciani F, 2017, 'B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle', , http://dx.doi.org/10.1101/181156
    Journal articles | 2017
    Rodrigo C; Eltahla AA; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Shoukry NH; Lauer GM; Maher L; Schinkel J; Prins M; Hellard M; Lloyd AR, 2017, 'Phylogenetic analysis of full-length, early infection, hepatitis C virus genomes among people with intravenous drug use: the InC3 Study', Journal of Viral Hepatitis, 24, pp. 43 - 52, http://dx.doi.org/10.1111/jvh.12616
    Journal articles | 2017
    Rodrigo C; Walker MR; Leung P; Eltahla AA; Grebely J; Dore GJ; Applegate T; Page K; Dwivedi S; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Luciani F; Lloyd AR; Bull RA, 2017, 'Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection', Infection, Genetics and Evolution, 49, pp. 88 - 96, http://dx.doi.org/10.1016/j.meegid.2017.01.006
    Journal articles | 2017
    Sierro F; Evrard M; Rizzetto S; Melino M; Mitchell AJ; Florido M; Beattie L; Walters SB; Tay SS; Lu B; Holz LE; Roediger B; Wong YC; Warren A; Ritchie W; McGuffog C; Weninger W; Le Couteur DG; Ginhoux F; Britton WJ; Heath WR; Saunders BM; McCaughan GW; Luciani F; MacDonald KPA; Ng LG; Bowen DG; Bertolino P, 2017, 'A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment', Immunity, 47, pp. 374 - 388.e6, http://dx.doi.org/10.1016/j.immuni.2017.07.018
    Journal articles | 2016
    Audsley J; Bent SJ; Littlejohn M; Avihingsanon A; Matthews G; Bowden S; Bayliss J; Luciani F; Yuen L; Fairley CK; Locarnini S; Lewin SR; Sasadeusz J, 2016, 'Effects of long-term tenofovir-based combination antiretroviral therapy in HIV-hepatitis B virus coinfection on persistent hepatitis B virus viremia and the role of hepatitis B virus quasispecies diversity', AIDS, 30, pp. 1597 - 1606, http://dx.doi.org/10.1097/QAD.0000000000001080
    Journal articles | 2016
    Bartlett SR; Jacka B; Bull RA; Luciani F; Matthews GV; Lamoury FMJ; Hellard ME; Hajarizadeh B; Teutsch S; White B; Maher L; Dore GJ; Lloyd AR; Grebely J; Applegate TL, 2016, 'HIV infection and hepatitis C virus genotype 1a are associated with phylogenetic clustering among people with recently acquired hepatitis C virus infection', Infection, Genetics and Evolution, 37, pp. 252 - 258, http://dx.doi.org/10.1016/j.meegid.2015.11.028
    Journal articles | 2016
    Betz-Stablein BD; Töpfer A; Littlejohn M; Yuen L; Colledge D; Sozzi V; Angus P; Thompson A; Revill P; Beerenwinkel N; Warner N; Luciani F, 2016, 'Single-molecule sequencing reveals complex genome variation of hepatitis B virus during 15 Years of chronic infection following liver transplantation', Journal of Virology, 90, pp. 7171 - 7183, http://dx.doi.org/10.1128/JVI.00243-16
    Journal articles | 2016
    Budzinska MA; Tu T; d'Avigdor WMH; McCaughan GW; Luciani F; Shackel NA, 2016, 'Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma.', PLoS One, 11, pp. e0162586, http://dx.doi.org/10.1371/journal.pone.0162586
    Journal articles | 2016
    Bull RA; Eltahla AA; Rodrigo C; Koekkoek SM; Walker M; Pirozyan MR; Betz-Stablein B; Toepfer A; Laird M; Oh S; Heiner C; Maher L; Schinkel J; Lloyd AR; Luciani F, 2016, 'A method for near full-length amplification and sequencing for six hepatitis C virus genotypes', BMC Genomics, 17, http://dx.doi.org/10.1186/s12864-016-2575-8
    Journal articles | 2016
    Eltahla AA; Rizzetto S; Pirozyan MR; Betz-Stablein BD; Venturi V; Kedzierska K; Lloyd AR; Bull RA; Luciani F, 2016, 'Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells', Immunology and Cell Biology, 94, pp. 604 - 611, http://dx.doi.org/10.1038/icb.2016.16
    Journal articles | 2016
    Fiches GN; Eyre NS; Aloia AL; Van Der Hoek K; Betz-Stablein B; Luciani F; Chopra A; Beard MR, 2016, 'HCV RNA traffic and association with NS5A in living cells', Virology, 493, pp. 60 - 74, http://dx.doi.org/10.1016/j.virol.2016.02.016
    Journal articles | 2016
    Keoshkerian E; Hunter M; Cameron B; Nguyen N; Sugden P; Bull R; Zekry A; Maher L; Seddiki N; Zaunders J; Kelleher A; Lloyd AR; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Luciani F, 2016, 'Hepatitis C-specific effector and regulatory CD4 T-cell responses are associated with the outcomes of primary infection', Journal of Viral Hepatitis, 23, pp. 985 - 993, http://dx.doi.org/10.1111/jvh.12576
    Journal articles | 2016
    Luciani F, 2016, 'High-throughput sequencing and vaccine design', OIE Revue Scientifique et Technique, 35, pp. 53 - 65, http://dx.doi.org/10.20506/rst.35.1.2417
    Journal articles | 2016
    Mina MM; Cameron B; Luciani F; Vollmer-Conna U; Lloyd AR, 2016, 'Natural killer cells in highly exposed hepatitis C-seronegative injecting drug users', Journal of Viral Hepatitis, 23, pp. 464 - 472, http://dx.doi.org/10.1111/jvh.12511
    Journal articles | 2016
    Rodrigo C; Eltahla AA; Bull RA; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Estes C; Razavi H; Lloyd AR; Luciani F, 2016, 'Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia', Journal of Infectious Diseases, 214, pp. 1383 - 1389, http://dx.doi.org/10.1093/infdis/jiw389
    Journal articles | 2016
    Walker MR; Li H; Teutsch S; Betz-Stablein B; Luciani F; Lloyd AR; Bull RA, 2016, 'Incident hepatitis c virus genotype distribution and multiple infection in australian prisons', Journal of Clinical Microbiology, 54, pp. 1855 - 1861, http://dx.doi.org/10.1128/JCM.00287-16
    Journal articles | 2016
    Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936, http://dx.doi.org/10.4103/1008-682X.163190
    Journal articles | 2015
    Applegate TL; Gaudieri S; Plauzolles A; Chopra A; Grebely J; Lucas M; Hellard M; Luciani F; Dore GJ; Matthews GV, 2015, 'Naturally occurring dominant drug resistance mutations occur infrequently in the setting of recently acquired hepatitis C', Antiviral Therapy, 20, pp. 199 - 208, http://dx.doi.org/10.3851/IMP2821
    Journal articles | 2015
    Arcuri C; Luciani F; Piva P; Bartuli FN; Ottria L; Mecheri B; Licoccia S, 2015, 'Dentistry waste treatment through enzymatic fuel cells', ORAL and Implantology, 8, pp. 12 - 18
    Journal articles | 2015
    Bretaña N; Boelen L; Bull R; Teutsch S; White P; Lloyd A; Luciani F, 2015, 'Transmission of Hepatitis C Virus among Prisoners, Australia, 2005–2012.', Emerging Infectious Diseases, http://dx.doi.org/10.3201/eid2105.141832
    Journal articles | 2015
    Bull RA; Leung P; Gaudieri S; Deshpande P; Cameron B; Walker M; Chopra A; Lloyd AR; Luciani F; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Maher L, 2015, 'Transmitted/founder viruses rapidly escape from CD8+ T cell responses in acute hepatitis C virus infection', Journal of Virology, 89, pp. 5478 - 5490, http://dx.doi.org/10.1128/JVI.03717-14
    Journal articles | 2015
    Eltahla AA; Luciani F; White PA; Lloyd AR; Bull RA, 2015, 'Inhibitors of the hepatitis C virus polymerase; mode of action and resistance', Viruses, 7, pp. 5206 - 5224, http://dx.doi.org/10.3390/v7102868
    Journal articles | 2015
    Giannitelli SM; Basoli F; Mozetic P; Piva P; Bartuli FN; Luciani F; Arcuri C; Trombetta M; Rainer A; Licoccia S, 2015, 'Graded porous polyurethane foam: A potential scaffold for oro-maxillary bone regeneration', Materials Science and Engineering C, 51, pp. 329 - 335, http://dx.doi.org/10.1016/j.msec.2015.03.002
    Journal articles | 2015
    Luciani F; Piva P; Caddeo F; Bartuli FN; Arcuri C, 2015, 'Medical waste to energy: Is it possible?', International Journal of Clinical Dentistry, 7, pp. 383 - 388
    Journal articles | 2015
    Mina MM; Luciani F; Cameron B; Bull RA; Beard MR; Booth D; Lloyd AR, 2015, 'Resistance to hepatitis C virus: Potential genetic and immunological determinants', The Lancet Infectious Diseases, 15, pp. 451 - 460, http://dx.doi.org/10.1016/S1473-3099(14)70965-X
    Journal articles | 2015
    Zarzour P; Boelen L; Luciani F; Beck D; Sakthianandeswaren A; Mouradov D; Sieber OM; Hawkins NJ; Hesson LB; Ward RL; Wong JWH, 2015, 'Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas', Genes Chromosomes and Cancer, 54, pp. 303 - 314, http://dx.doi.org/10.1002/gcc.22243
    Journal articles | 2014
    Arcuri C; Luciani F; Piva P; Bartuli FN; Ottria L; Mecheri B; Licoccia S, 2014, 'Medical waste to energy: Experimental study', ORAL and Implantology, 6, pp. 83 - 88, http://dx.doi.org/10.11138/orl/2013.6.4.083
    Journal articles | 2014
    Ayres A; Yuen L; Jackson KM; Manoharan S; Glass A; Maley M; Yoo W; Hong SP; Kim SO; Luciani F; Bowden DS; Bayliss J; Levy MT; Locarnini SA, 2014, 'Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: Lack of potency and selection of resistance mutations', Journal of Viral Hepatitis, 21, pp. 809 - 817, http://dx.doi.org/10.1111/jvh.12212
    Journal articles | 2014
    Bartuli FN; Piva P; Savo A; Di Dio M; Luciani F; Arcuri C, 2014, 'Lower third molar germectomy: The flap recovery on the lower second molar. a clinical study', International Journal of Clinical Dentistry, 7, pp. 289 - 294
    Journal articles | 2014
    Bellavista E; Santoro A; Galimberti D; Comi C; Luciani F; Mishto M, 2014, 'Current understanding on the role of standard and immunoproteasomes in inflammatory/immunological pathways of multiple sclerosis', Autoimmune Diseases, 2014, http://dx.doi.org/10.1155/2014/739705
    Journal articles | 2014
    Boelen L; Teutsch S; Wilson DP; Dolan K; Dore GJ; Lloyd AR; Luciani F, 2014, 'Per-event probability of hepatitis C infection during sharing of injecting equipment', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0100749
    Journal articles | 2014
    Hartfield M; Bull R; White PA; Lloyd A; Luciani F; Alizon S, 2014, 'Evidence that hepatitis C virus genome partly controls infection outcome', Evolutionary Applications, 7, pp. 533 - 547, http://dx.doi.org/10.1111/eva.12151
    Journal articles | 2014
    Leung P; Bull R; Lloyd A; Luciani F, 2014, 'A bioinformatics pipeline for the analyses of viral escape dynamics and host immune responses during an infection', BioMed Research International, 2014, http://dx.doi.org/10.1155/2014/264519
    Journal articles | 2014
    Luciani F; Bretaña NAR; Teutsch S; Amin J; Topp L; Dore GJ; Maher L; Dolan K; Lloyd AR, 2014, 'A prospective study of hepatitis C incidence in Australian prisoners', Addiction (Abingdon, England), 109, pp. 1695 - 1706, http://dx.doi.org/10.1111/add.12643
    Journal articles | 2014
    Luciani F; Bretaña NAR; Teutsch S; Amin J; Topp L; Dore GJ; Maher L; Dolan K; Lloyd AR, 2014, 'A prospective study of hepatitis C incidence in Australian prisoners', Addiction (Abingdon, England), 109, pp. 1695 - 1706, http://dx.doi.org/10.1111/add.12643
    Journal articles | 2014
    McElroy K; Thomas T; Luciani F, 2014, 'Deep sequencing of evolving pathogen populations: applications, errors, and bioinformatic solutions.', Microb Inform Exp, 4, pp. 1, http://dx.doi.org/10.1186/2042-5783-4-1
    Journal articles | 2014
    Sugden PB; Cameron B; Luciani F; Lloyd AR, 2014, 'Exploration of genetically determined resistance against hepatitis C infection in high-risk injecting drug users', Journal of Viral Hepatitis, 21, pp. e65 - e73, http://dx.doi.org/10.1111/jvh.12232
    Journal articles | 2014
    Sugden PB; Cameron B; Mina M; Lloyd AR, 2014, 'Protection against hepatitis C infection via NK cells in highly-exposed uninfected injecting drug users', Journal of Hepatology, 61, pp. 738 - 745, http://dx.doi.org/10.1016/j.jhep.2014.05.013
    Journal articles | 2014
    Tu T; Budzinska M; McCaughan GW; McLennan SV; Luciani F; Shackel N, 2014, 'DELETERIOUS PASSENGER MUTATIONS AS A BIOMARKER FOR HEPATOCELLULAR CARCINOMA', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 10, pp. 44 - 44, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2014
    Töpfer A; Marschall T; Bull RA; Luciani F; Schönhuth A; Beerenwinkel N, 2014, 'Viral quasispecies assembly via maximal clique enumeration', Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 8394 LNBI, pp. 309 - 310, http://dx.doi.org/10.1007/978-3-319-05269-4-25
    Journal articles | 2013
    Bartuli FN; Luciani F; Caddeo F; De Chiara L; Di Dio M; Piva P; Ottria L; Arcuri C, 2013, 'Piezosurgery vs high speed rotary handpiece: A comparison between the two techniques in the impacted third molar surgery', ORAL and Implantology, 6, pp. 5 - 10, http://dx.doi.org/10.11138/orl/2013.6.1.005
    Journal articles | 2013
    Bartuli FN; Piva P; Caddeo F; Luciani F; Arcuri C, 2013, 'Squamous cell carcinoma of the oral cavity and hyperhomocysteinemia. There's a correlation? A preliminary study', International Journal of Clinical Dentistry, 6, pp. 219 - 225
    Journal articles | 2013
    Cameron B; Galbraith S; Li H; Lloyd A; HITS investigators , 2013, 'Correlates and characteristics of hepatitis C virus-specific T-cell immunity in exposed uninfected high-risk prison inmates', Journal of Viral Hepatitis, 20, pp. e96 - e106, http://dx.doi.org/10.1111/jvh.12016
    Journal articles | 2013
    Luciani F; Cecchetti F; Piva P; Motta A; Bartuli FN; Arcuri C, 2013, 'Gingival hypertrophy- hyperplasia? peripheral ameloblastoma!', International Journal of Clinical Dentistry, 6, pp. 1 - 10
    Journal articles | 2013
    Luciani F; Sanders MT; Oveissi S; Pang KC; Chen W, 2013, 'Increasing viral dose causes a reversal in CD8+ T cell immunodominance during primary influenza infection due to differences in antigen presentation, T cell avidity, and precursor numbers', Journal of Immunology, 190, pp. 36 - 47, http://dx.doi.org/10.4049/jimmunol.1200089
    Journal articles | 2013
    Sugden PB; Pham TN; Ratnarajah S; Cameron B; Bull R; White PA; Michalak TI; Lloyd AR, 2013, 'Rare occurrence of occult hepatitis C virus in apparently uninfected injecting drug users: a two-centre, masked, case-control study', J Viral Hepat, 20, pp. 725 - 728, http://dx.doi.org/10.1111/jvh.12098
    Journal articles | 2012
    Bull RA; Eden J-S; Luciani F; McElroy K; Rawlinson WD; White PA, 2012, 'Contribution of intra- and interhost dynamics to norovirus evolution', Journal of Virology, 86, pp. 3219 - 3229, http://dx.doi.org/10.1128/JVI.06712-11
    Journal articles | 2012
    Luciani F; Bull RA; Lloyd AR; Bull , 2012, 'Next generation deep sequencing and vaccine design: Today and tomorrow', Trends in Biotechnology, 30, pp. 443 - 452, http://dx.doi.org/10.1016/j.tibtech.2012.05.005
    Journal articles | 2012
    McElroy KE; Luciani F; Thomas T, 2012, 'GemSIM: General, Error-Model based SIMulator of next-generation sequencing data', BMC Genomics, 13, pp. 1 - 9, http://dx.doi.org/10.1186/1471-2164-13-74
    Journal articles | 2012
    Mccredie L; Luciani F; Teutsch S; Amin J; Topp L; Dolan K; Lloyd A, 2012, 'BLOODY PRISONS: INCIDENCE OF RISK BEHAVIOURS AND HEPATITIS C VIRUS TRANSMISSION IN AN AUSTRALIAN PRISONER COHORT', DRUG AND ALCOHOL REVIEW, 31, pp. 57 - 57, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000311236700175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Nguyen N; Luciani F; Cameron B; Keoshkerian E; Zekry A; Lloyd A, 2012, '801 T CELLS CO-EXPRESSING CCR2, CCR5, CXCR3, AND CXCR6 ARE PREFERENTIALLY ENRICHED IN THE HCV-INFECTED LIVER', Journal of Hepatology, 56, pp. S313 - S313, http://dx.doi.org/10.1016/s0168-8278(12)60813-7
    Journal articles | 2011
    Bartuli FN; Luciani F; Caddeo F; Panetta V; Nisi A; Cecchetti F; Arcuri C, 2011, 'Biopsy of oral cavity: A retrospective study 10 years', International Journal of Clinical Dentistry, 4, pp. 329 - 341
    Journal articles | 2011
    Bull RA; Luciani F; McElroy K; Gaudieri S; Pham ST; Chopra A; Cameron B; Maher L; Dore GJ; White PA; Lloyd AR, 2011, 'Sequential Bottlenecks Drive Viral Evolution in Early Acute Hepatitis C Virus Infection', PLoS Pathog, 7, pp. e1002243, http://dx.doi.org/10.1371/journal.ppat.1002243
    Journal articles | 2011
    McElroy K; Luciani F; Hui J; Rice S; Thomas T, 2011, 'Bacteriophage evolution drives Pseudomonas aeruginosa PAO1 biofilm diversification', BMC Bioinformatics, 12, pp. A2 - A2
    Journal articles | 2011
    Samuel A; Regoes RR; Luciani F, 2011, 'Epidemiological and clinical consequences of within-host evolution.', Trends in Microbiology, 19, pp. 24 - 32
    Journal articles | 2010
    Cecchetti F; Luciani F; Serafico L; Bartuli FN; Arcuri C, 2010, 'Floor of the mouth's lipoma: A retrospective study ten years', International Journal of Clinical Dentistry, 3, pp. 111 - 120
    Journal articles | 2010
    Mclean A; Luciani F; Tanaka M, 2010, 'Trade-offs in resource allocation in the intracellular life-cycle of hepatitis C virus', Journal of Theoretical Biology, 267, pp. 565 - 572, http://dx.doi.org/10.1016/j.jtbi.2010.09.031
    Journal articles | 2009
    Luciani F; Sisson SA; Jiang H; Francis AR; Tanaka M, 2009, 'The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 14711 - 14715, http://dx.doi.org/10.1073/pnas.0902437106
    Journal articles | 2008
    Luciani F; Francis AR; Tanaka M, 2008, 'Interpreting genotype cluster sizes of Mycobacterium tuberculosis isolates typed with IS6110 and spoligotyping', Infection Genetics and Evolution, 8, pp. 182 - 190, http://dx.doi.org/10.1016/j.meegid.2007.12.004
    Journal articles | 2008
    Mishto M; Luciani F; Holzhutter H; Bellavista E; Santoro A; Textoris-Taube K; Franceschi C; Kloetzel P; Zaikin A, 2008, 'Modeling the in vitro 20S proteasome activity: The effect of PA28-alpha beta and of the sequence and length of polypeptides on the degradation kinetics', Journal of Molecular Biology, 377, pp. 1607 - 1617, http://dx.doi.org/10.1016/j.jmb.2008.01.086
    Journal articles | 2008
    Mishto M; Luciani F; Holzhutter H; Bellavista E; Santoro A; Textoris-Taube K; Franceschi C; Kloetzel P; Zaikin A, 2008, 'Proteasome modelling algorithm to predict in vitro kinetics of 20S proteasome degradation', Journal of Molecular Biology, 377, pp. 1607 - 1617, http://dx.doi.org/10.1016/j.jmb.2008.01.086
    Journal articles | 2008
    Pomati F; Orlandi C; Clerici M; Luciani F; Zuccato E, 2008, 'Effects and interactions in an environmentally relevant mixture of pharmaceuticals', Toxicological Sciences, 102, pp. 129 - 137, http://dx.doi.org/10.1093/toxsci/kfm291
    Journal articles | 2008
    Tang C; Reyes JF; Luciani F; Francis AR; Tanaka M, 2008, 'spolTools: online utilities for analyzing spoligotypes of the Mycobacterium tuberculosis complex', Bioinformatics, 24, pp. 2414 - 2415, http://dx.doi.org/10.1093/bioinformatics/btn434
    Journal articles | 2006
    Tanaka M; Francis AR; Luciani F; Sisson SA, 2006, 'Using approximate Bayesian computation to estimate tuberculosis transmission parameters from genotype data', Genetics, 173, pp. 1511 - 1520, http://dx.doi.org/10.1534/genetics.106.055574
    Journal articles | 2005
    Luciani F; Kesmir C; Mishto M; Or-guil M; De Boer RJ, 2005, 'A mathematical model of protein degradation by the proteasome', Biophysical Journal, 88, pp. 2422 - 2432, http://bioinformatics.bio.uu.nl/rdb/pdf/Luciani_bj05.pdf
    Journal articles | 2004
    Bertuccio SN; Pellicanò S; Calzone R; Ranieri SF; Rombolà F; Bertuccio A; Luciani F, 2004, 'Prophylaxis of Herpes simplex virus. Personal experience', Gazzetta Medica Italiana Archivio per le Scienze Mediche, 163, pp. 1 - 3
    Journal articles | 2004
    Pellicanò S; Calzone R; Luciani F; Terra M; Terra L, 2004, 'Acute anicteric viral hepatitis type A with anomalous course. A case report', Gazzetta Medica Italiana Archivio per le Scienze Mediche, 163, pp. 27 - 30
    Journal articles | 2004
    Terra M; Pellicanò S; Calzone R; Luciani F; Terra L; Terra R, 2004, 'Hematologic changes during AIDS infection. A case report', Gazzetta Medica Italiana Archivio per le Scienze Mediche, 163, pp. 19 - 21
    Journal articles | 2003
    Fedeli D; Fedeli A; Luciani F; Massi M; Falcioni G; Polidori C, 2003, 'Lymphocyte DNA alteration by sub-chronic ethanol intake in alcohol-preferring rats', Clinica Chimica Acta, 337, pp. 43 - 48, http://dx.doi.org/10.1016/S0009-8981(03)00329-2
    Journal articles | 2003
    Polidori C; Luciani F; Fedeli A; Geary N; Massi M, 2003, 'Leptin fails to reduce ethanol intake in Marchigian Sardinian alcohol-preferring rats', Peptides, 24, pp. 1441 - 1444, http://dx.doi.org/10.1016/j.peptides.2003.09.008
    Journal articles | 2001
    Luciani F; Turchetti G; Franceschi C; Valensin S, 2001, 'A Mathematical Model for the Immunosenescence', Rivista di Biologia - Biology Forum, 94, pp. 305 - 318
    Journal articles | 2001
    Luciani F; Valensin S; Vescovini R; Sansoni P; Fagnoni F; Franceschi C; Bonafè M; Turchetti G, 2001, 'A stochastic model for CD8+ T cell dynamics in human immunosenescence: Implications for survival and longevity', Journal of Theoretical Biology, 213, pp. 587 - 597, http://dx.doi.org/10.1006/jtbi.2001.2433
  • Conference Papers | 2023
    Shek D; Gao B; Mahajan H; Nagrial A; Carlino M; Luciani F; Read S; Ahlenstiel G, 2023, '177 Exploring the relationship between tumour heterogeneity and response to immunotherapy in malignant pleural mesothelioma', in Regular and Young Investigator Award Abstracts, BMJ Publishing Group Ltd, presented at SITC 38th Annual Meeting (SITC 2023) Abstracts, http://dx.doi.org/10.1136/jitc-2023-sitc2023.0177
    Preprints | 2022
    Ghita L; Yao Z; Xie Y; Duran V; Cagirici HB; Samir J; Osman I; Agudelo Rojas OL; Sanz AM; Sahoo MK; Robinson ML; Gelvez RM; Bueno N; Luciani F; Pinsky BA; Montoya JG; Estupiñan Cardenas MI; Villar Centeno LA; Rojas Garrido EM; Rosso F; Quake SR; Zanini F; Einav S, 2022, Global and cell type-specific immunological hallmarks of severe dengue progression, , http://dx.doi.org/10.1101/2022.12.11.519930
    Preprints | 2022
    Louie R; Cai C; Singh M; Deveson I; Ferguson J; Amos T; McGuire H; Samir J; Gowrishankar K; Adikari T; Balderas R; Bishop D; Gottlieb D; Blyth E; Micklethwaite K; Luciani F, 2022, CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion, , http://dx.doi.org/10.21203/rs.3.rs-1495587/v1
    Preprints | 2022
    Louie RHY; Cai C; Singh M; Deveson I; Ferguson J; Amos T; McGuire HM; Samir J; Gowrishankar K; Adikari T; Balderas R; Bishop D; Gottlieb D; Blyth E; Micklethwaite K; Luciani F, 2022, CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion, , http://dx.doi.org/10.1101/2022.03.29.22273013
    Conference Papers | 2021
    Adikari TN; Singh M; Munier ML; Louie R; Samir J; Balraj V; Cai C; Hardy MY; John JR; Reid H; Kelleher AD; Din JAT; Goodnow C; Luciani F, 2021, 'Single cell RNA sequencing of gluten-specific CD4+T cells reveals a novel gene expression pattern with NK-like cytotoxicity', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, pp. 96 - 96, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000753366400285&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2021
    Cai C; Samir J; Pirozyan M; Adikari T; Gupta M; Leung P; Hughes B; Van der Byl W; Rizzetto S; Elthala A; Keoshkerian E; Palgen J-L; Peters T; Nguyen T; Louie R; Kedzierska K; Gaudieri S; Bull R; Lloyd A; Luciani F, 2021, Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8+ T cells, , http://dx.doi.org/10.1101/2021.09.09.459584
    Conference Papers | 2021
    Louie R; Cai C; Balraj V; Singh M; Jackson K; Deveson I; Ferguson J; Amos T; Gowrishankar K; Bishop D; Blyth E; Gottlieb D; Micklethwaite K; Luciani F, 2021, 'Single cell multi-omics identifies evolving phenotypes of CAR CD19 and endogenous T cell clones', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, pp. 412 - 412, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000753366402197&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2021
    Tikoo S; Jain R; Martinez B; Song R; Wielscher M; Rizzetto S; Shaw LE; Mitchell AJ; Torres-Pacheco ME; Luciani F; Farlik M; Wong JJL; Jung S; Fraser ST; Weninger W, 2021, A distinct CD115-erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice, , http://dx.doi.org/10.1101/2021.07.24.453629
    Conference Papers | 2021
    Zhao Y; Keoshkerian E; Li H; An H; Bull RA; Luciani F; Lloyd AR, 2021, 'Functional characterisation and transcriptomic analysis of antigen-specific CD8 T memory stem cells (TSCM) generated from clonally expanded single TSCM cells in vitro', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, pp. 47 - 47, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000753366400123&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2020
    Bull R; Adikari T; Ferguson J; Hammond J; Stevanovski I; Beukers A; Naing Z; Yeang M; Verich A; Gamaarachchi H; Kim KW; Luciani F; Stelzer-Braid S; Eden J-S; Rawlinson W; van Hal S; Deveson I, 2020, Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis, , http://dx.doi.org/10.1101/2020.08.04.236893
    Preprints | 2020
    Samir J; Rizzetto S; Gupta M; Luciani F, 2020, Exploring and analysing single cell multi-omics data with VDJView, , http://dx.doi.org/10.21203/rs.2.14949/v3
    Preprints | 2020
    Samir J; Rizzetto S; Gupta M; Luciani F, 2020, Exploring and analysing single cell multi-omics data with VDJView, , http://dx.doi.org/10.21203/rs.2.14949/v4
    Conference Abstracts | 2020
    Singh M; Jackson K; Wang JJ; Schofield P; Field M; Rischmueller M; Luciani F; Gordon T; Goodnow C; Reed J, 2020, 'GENOMIC ANALYSIS OF B CELLS PRODUCING PATHOGENIC RHEUMATOID FACTORS', in INTERNAL MEDICINE JOURNAL, WILEY, Vol. 50, pp. 47 - 47, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000553988700131&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2020
    Sutton HJ; Aye R; Idris AH; Vistein R; Nduati E; Kai O; Mwacharo J; Li X; Gao X; Andrews TD; Koutsakos M; Nguyen THO; Nekrasov M; Milburn P; Ethala A; Berry AA; Natasha KC; Chakravarty S; Sim BKL; Wheatley AK; Kent SJ; Hoffman SL; Lyke KE; Bejon P; Luciani F; Kedzierska K; Seder RA; Ndungu FM; Cockburn IA, 2020, Atypical B cells are a normal component of immune responses to vaccination and infection in humans, , http://dx.doi.org/10.1101/2020.05.28.120808
    Conference Presentations | 2019
    Rodrigo C; Leung P; Bull R; Lloyd A; Luciani F, 2019, 'Using networks to study epistatic interactions of HCV', presented at 14th Scientific Workship of the Australian Center for HIV and Hepatitis Virology Research, Canungra, Australia
    Conference Presentations | 2019
    Rodrigo C; Riaz N; Adikari T; Sigera C; Rajapakse S; Fernando D; Weeratunga P; Fink K; Bull R; Luciani F; Lloyd A, 2019, 'A single nested PCR method for full length dengue virus genome amplification', presented at 7th European Congress of Virology, Rotterdam, The Netherlands
    Preprints | 2019
    Samir J; Rizzetto S; Gupta M; Luciani F, 2019, Exploring and analysing immune single cell multi-omics data with VDJView, , http://dx.doi.org/10.1101/613083
    Preprints | 2019
    Samir J; Rizzetto S; Gupta M; Luciani F, 2019, Exploring and analysing single cell multi-omics data with VDJView, , http://dx.doi.org/10.21203/rs.2.14949/v1
    Preprints | 2019
    Samir J; Rizzetto S; Gupta M; Luciani F, 2019, Exploring and analysing single cell multi-omics data with VDJView, , http://dx.doi.org/10.21203/rs.2.14949/v2
    Conference Papers | 2019
    Singh M; Jackson K; Wang JJ; Schofield P; Field M; Peters T; Luciani F; Gordon T; Goodnow C; Reed JH, 2019, '241 Single cell genomics of self-reactive B cells reveals the evolution from benign to pathogenic autoantibody and strategies for early diagnosis and personalised treatment', in Abstracts, Lupus Foundation of America, presented at 13th International Congress on Systemic Lupus Erythematosus (LUPUS 2019), San Francisco, California, USA, April 5–8, 2019, Abstract Presentations, http://dx.doi.org/10.1136/lupus-2019-lsm.241
    Conference Presentations | 2018
    Abayasingam A; Leung P; Luciani F; Bull R; Lloyd A; Rodrigo C, 2018, 'Challenges in characterizing hepatitis C virus founder variants with deep sequencing', presented at 13th National Scientific Workshop of the Australian Center for HIV and Hepatitis Virology Research
    Conference Posters | 2018
    Cunningham EB; Hajarizadeh B; Amin J; Betz-Stablein B; Dore GJ; Luciani F; Teutsch S; Bretana NA; Dolan K; Lloyd AR; Grebely J, 2018, 'A161 ONGOING INCIDENT HEPATITIC C VIRUS INFECTION AMONG PEOPLE WITH A HISTORY OF INJECTING DRUG USE IN AN AUSTRALIAN PRISON SETTING', Vol. 1, pp. 278 - 280, http://dx.doi.org/10.1093/jcag/gwy008.162
    Conference Presentations | 2018
    Rodrigo C; Eltahla A; Bull R; Luciani F; Lloyd A, 2018, 'Genetic variability of Hepatitis C quasi-species in early infection', presented at Global Hepatitis Summit, Toronto, Canada
    Conference Presentations | 2018
    Rodrigo C; Eltahla A; Bull R; Luciani F; Lloyd A, 2018, 'Host IFNλ3 genotype and viral genotype are key determinants of within-host HCV genomic variation in early infection', presented at 13th National Scientific Workshop of the Australian Center for HIV and Hepatitis Virology Research, Yarra Valley, Australia
    Conference Papers | 2017
    Cunningham EB; Hajarizadeh B; Amin J; Bretana NA; Luciani F; Degenhardt L; Larney S; Dore GJ; Lloyd AR; Grebely J, 2017, 'Injecting risk behaviours among people with a history of injecting drug use in an Australian prison setting, 2005-2014: the HITS-p study', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, NETHERLANDS, Amsterdam, pp. S488 - S488, presented at International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, NETHERLANDS, Amsterdam, 19 April 2017 - 23 April 2017, http://dx.doi.org/10.1016/S0168-8278(17)31370-3
    Conference Papers | 2017
    Horton JL; Kim KW; Pang CN; Jain K; Leung P; Isaacs SR; Bull RA; Luciani F; Wilkins MR; Lipkin WI; Rawlinson WD; Briese T; Craig ME, 2017, 'Virome-Capture Sequencing of the Gut and Plasma Virome in Children with Islet Autoimmunity', in DIABETES, AMER DIABETES ASSOC, pp. LB51 - LB52, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000463087200190&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2017
    Rodrigo C; Eltahla A; Bull R; Luciani F; Lloyd A, 2017, 'Establishment of InC3 viral sequence repository and its applications', presented at 12th National Scientific Workshop of the Australian Center for HIV and Hepatitis Virology Research, Barossa Valley, Australia
    Conference Abstracts | 2016
    Budzinska MA; Tu T; D'avigdo WMH; Mccaughan GW; Luciani F; Shackel NA, 2016, 'Accumulation of deleterious passenger mutations is associated with the progression of hepatocellular carcinoma', in PLoS ONE, Vol. 11, http://dx.doi.org/10.1371/journal.pone.0162586
    Conference Papers | 2016
    Cunningham EB; Luciani F; Hajarizadeh B; Betz-Stablein B; Bretana NA; Teutsch S; Dore GJ; Grebely J; Lloyd AR, 2016, 'STABLE INCIDENCE OF HEPATITIS C VIRUS INFECTION AMONG PEOPLE WITH A HISTORY OF INJECTING DRUG USE IN AN AUSTRALIAN PRISON SETTING, 2005-2014: THE HITS-P STUDY', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, SPAIN, Barcelona, pp. S614 - S614, presented at EASL International Liver Congress, SPAIN, Barcelona, 13 April 2016 - 17 April 2016, http://dx.doi.org/10.1016/S0168-8278(16)01138-7
    Conference Presentations | 2016
    Rodrigo C; Bretana N; Luciani F; Lloyd A; Bull R, 2016, 'Examining past and future hepatitis C virus epidemic trends in the era of directly acting antivirals', presented at Australian Society of Microbiology annual scientific meeting, Perth, Australia
    Conference Presentations | 2016
    Rodrigo C; Eltahla A; Bull R; Lloyd A; Luciani F, 2016, 'Bayesian evolutionary analysis of hepatitis C epidemic in Australia and North America in 20th century', presented at Australasian Viral Hepatitis Conference, GoldCoast, Australia
    Conference Presentations | 2016
    Rodrigo C; Eltahla A; Bull R; Lloyd A; Luciani F, 2016, 'Bayesian evolutionary analysis of hepatitis C epidemic in Australia and North America in 20th century', presented at International conference in Systems Biology, Barcelona, Spain
    Conference Presentations | 2016
    Rodrigo C; Eltahla A; Bull R; Lloyd A; Luciani F, 2016, 'Broadly neutralizing antibodies against hepatitis C envelope; using a network approach to understand co-evolution of critical residues', presented at International conference in Systems Biology, Barcelona, Spain
    Conference Presentations | 2016
    Rodrigo C; Eltahla A; Bull R; Luciani F; Lloyd A, 2016, 'Molecular epidemiology of full length hepatitis C virus genomes among injecting drug users with recent infection: The InC3 study', presented at 5th International Symposium on Hepatitis Care in Substance Users, Oslo, Norway
    Conference Presentations | 2016
    Rodrigo C; Eltahla A; Bull R; Luciani F; Lloyd A, 2016, 'Trends of Hepatitis C virus infections in North America and Australia in 20th century; back projections from molecular epidemiology', presented at 5th International Symposium on Hepatitis Care in Substance Users, Oslo, Norway
    Conference Abstracts | 2015
    Budzinska MA; Tu T; Luciani F; Shackel NA, 2015, 'Deleterious passenger mutations as a marker for progression towards liver cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 30, pp. 4 - 5, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2015
    Eltahla A; Rodrigo C; Bull R; Luciani F; Lloyd A, 2015, 'Natural prevalence of HCV resistance associated variants in treatment naïve patients across six genotypes', presented at 11th National Scientific Workshop of the Australian Center for HIV and Hepatitis Virology Research, Hunter Valley, Australia
    Conference Papers | 2015
    Leung P; Bull R; Lloyd A; Luciani F, 2015, 'Co-evolving mutations in hepatitis C virus in the context of immune escape against neutralising antibody responses - A bioinformatic workflow for the analysis of co-evolving mutations in viral genomes', in International Workshop on Artificial Immune Systems, AIS 2015/ICSI3 2015 - Systems Immunology, Immunoinformatics and Immune-computation: Immunology without Borders, Proceedings, Sicily, Italy, presented at 2015 International Workshop on Artificial Immune Systems (AIS), Sicily, Italy, 17 July 2015 - 18 July 2015, http://dx.doi.org/10.1109/AISW.2015.7469236
    Conference Presentations | 2015
    Leung P; Walker M; Rodrigo C; Eltahla A; Bull R; Lloyd A; Luciani F, 2015, 'A network approach for the identification of co-evolving mutations in Hepatitis C Virus (HCV) in the context of immune escape against neutralizing antibody responses', presented at COMBINE Student Symposium, Sydney, Australia
    Conference Presentations | 2015
    Leung P; Walker M; Rodrigo C; Eltahla A; Bull R; Lloyd A; Luciani F, 2015, 'Identification of co-evolving mutations of the Hepatitis C virus in the context of immune escape against neutralizing antibody responses using a bioinformatics workflow', presented at 8th Australasian virology society meeting, Hunter Valley, Australia
    Conference Presentations | 2015
    Rodrigo C; Eltahla A; Bull R; Luciani F; Lloyd A, 2015, 'Global molecular epidemiology of acute hepatitis infection via phylogenetic analysis of full length genomes across nine international cohorts', presented at 11th National Scientific Workshop of the Australian Center for HIV and Hepatitis Virology Research, Hunter Valley, Australia
    Conference Presentations | 2015
    Walker M; Leung P; Eltahla A; Rodrigo C; Luciani F; Foung S; Lloyd A; Bull R, 2015, 'Understanding the timing, breadth and potency of neutralising antibody responses against transmitted/founders', presented at 11th National Scientific Workshop of the Australian Center for HIV and Hepatitis Virology Research, Hunter Valley, Australia
    Conference Papers | 2014
    1. D. Bradshaw, B. Jacka, F. Lamoury, T.L. Applegate, G.J. Dore, I. Down, G. Matthews, R. Sacks-Davis, M. Hellard, F. Luciani, M. Danta, J. Sasadeusz , 2014, 'A novel method comparing sexual networks with the HCV phylogeny in HIV-positive men who have sex with men (MSM) with acute HCV infection identifies two potential intervention targets for permucosally transmitted HCV', Boston, presented at AASLD, Boston, 05 November 2014 - 09 November 2014
    Conference Papers | 2014
    Bradshaw D; Jacka B; Sacks-Davis R; Lamoury F; Applegate T; Dore G; Down I; Luciani F; Hellard M; Sasadeusz J; Danta M; Matthews G, 2014, 'A novel method comparing sexual networks with the HCV phylogeny in HIV-positive MSM with acute HCV infection identifies two potential intervention targets for permucosally transmitted HCV in Australia', in HIV MEDICINE, WILEY-BLACKWELL, pp. 136 - 136, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333652300418&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Töpfer A; Marschall T; Bull RA; Luciani F; Schönhuth A; Beerenwinkel N, 2014, 'Viral quasispecies assembly via maximal clique enumeration', in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), pp. 309 - 310, http://dx.doi.org/10.1007/978-3-319-05269-4_25
    Conference Papers | 2013
    Boelen L; Bull RA; Teutsch S; Lloyd AR; Luciani F, 2013, 'MOLECULAR EPIDEMIOLOGY AND SOCIAL NETWORK ANALYSIS TO TRACK HCV TRANSMISSION IN HIGH-RISK COMMUNITIES: INJECTING DRUG USERS IN PRISONS OF NEW SOUTH WALES, AUSTRALIA', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, NETHERLANDS, Amsterdam, pp. S193 - S193, presented at International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), NETHERLANDS, Amsterdam, 24 April 2013 - 28 April 2013, http://dx.doi.org/10.1016/S0168-8278(13)60473-0
    Conference Papers | 2013
    Bradshaw D; Jacka B; Sacks-Davis R; Lamoury F; Applegate TL; Dore GJ; Down I; Luciani F; Hellard M; Sasadeusz J; Danta M; Matthews G, 2013, 'A novel method comparing sexual networks with the HCV phylogeny in HIV-positive men who have sex with men (MSM) with acute HCV infection identifies two potential intervention targets for permucosally-transmitted HCV', in HEPATOLOGY, WILEY-BLACKWELL, DC, Washington, pp. 1307A - 1307A, presented at 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases, DC, Washington, 01 November 2013 - 05 November 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330252206224&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Luciani F; Bull RA; Cameron B; Gaudieri S; Nguyen N; Yuen D; White PA; Purcell DFJ; Foung S; Lloyd AR, 2012, 'IMMUNE RESPONSES AGAINST FOUNDER HEPATITIS C VIRUSES IN ACUTE ASYMPTOMATIC SUBJECTS', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, SPAIN, Barcelona, pp. S312 - S312, presented at 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), SPAIN, Barcelona, 18 April 2012 - 22 April 2012, http://dx.doi.org/10.1016/S0168-8278(12)60809-5
    Conference Papers | 2011
    Luciani F; Bull R; McElroy K ; Pham S ; Cameron B ; Chopra A ; Gaudieri S ; Cooper D ; Lloyd A ; White P , 2011, 'EVOLUTIONARY DYNAMICS OF HEPATITIS C VIRUS DURING VERY EARLY INFECTIONS: VIROLOGICAL AND IMMUNOLOGICAL INSIGHTS', Berlin, presented at International Liver Conference 2011, Berlin, 30 March 2011 - 01 April 2011
    Conference Papers | 2011
    Luciani F; Bull R; Mcelroy K; Pham S; Cameron B; Chopra A; Gaudieri S; Cooper D; Lloyd A; White P, 2011, 'EVOLUTIONARY DYNAMICS OF HEPATITIS C VIRUS DURING VERY EARLY INFECTIONS: VIROLOGICAL AND IMMUNOLOGICAL INSIGHTS', in JOURNAL OF HEPATOLOGY, ELSEVIER, GERMANY, Berlin, pp. S18 - S18, presented at 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), GERMANY, Berlin, 30 March 2011 - 03 April 2011, http://dx.doi.org/10.1016/S0168-8278(11)60040-8
    Conference Papers | 2011
    Luciani F; McElroy K ; J Hui ; S Rice ; Thomas T , 2011, '13. K McElroy, F Luciani, J Hui, S Rice, T Thomas Bacteriophage evolution drives Pseudomonas aeruginosa PAO1 biofilm diversification. 2011 BMC Bioinformatics 12 (Suppl 11), A2', Vienna (Austria), presented at Highlights from the Seventh International Society for Computational Biology (ISCB) Student Council Symposium 2011, Vienna (Austria), 11 July 2011 - 15 July 2011
    Conference Papers | 2004
    Or-guil M; Luciani F; Carneiro J, 2004, 'Clonal expansion of cytotoxic T cell clones: the role of the Immunoproteasome', in Proceedings of the 5th Symposium on Mathematical and Computational Biology, E-papers Servicos Editoriais, Brazil, presented at 5th Symposium on Mathematical and Computational Biology
    Conference Papers | 2002
    MARIANI L; TURCHETTI G; LUCIANI F, 2002, 'STOCHASTIC MODELS OF IMMUNE SYSTEM AGING', in Modelling Biomedical Signals, WORLD SCIENTIFIC, presented at Modelling Biomedical Signals, http://dx.doi.org/10.1142/9789812778055_0007
    Conference Papers | 2002
    Turchetti G; Luciani F; Mariani L, 2002, 'Environmental randomness and survival probability', in Mathematical Modelling in Biology and Medicine, Co., Bologna, Italy, presented at 5th ESMTB Conference, Milano, Italy, 02 July 2002 - 06 July 2002

I have received fundings from NHMCR: Career development fellowship (2017-2021), Project and Ideas grants since 2012.

NIH R01

Private funding from industry involved in technology development and single cell genomics.

As a theoretical physicist by training, I utilise an interdisciplinary approach to understand these responses. In particular, I am a Systems Immunologist.  Systems immunology is an interdisciplinary field that applies systems biology and computational modeling approaches to study the immune system as a complex and integrated system. It aims to understand the dynamic interactions and behaviors of various components of the immune system, such as immune cells, proteins, and signaling pathways, in response to infections, diseases, and other biological challenges.

Key aspects and goals of my systems immunology research include 

  1. Integration of Data: integrate large datasets from various sources, including genomics, transcriptomics, proteomics, and immunophenotyping, to gain a comprehensive view of immune system function.

  2. Network Analysis of T cell receptors: we use a network approach to infer key properties of immune receptors such as their specificity, and cross-reactive responses across pathogens and self. 

  3. Coeliac Disease  We aim to gain insights into the immune responses associated with coeliac diseases, and specifically in those immune cells that acquire somatic mutations and go rogue, breaking the natural immunological tolerance.

  4. Personalized Medicine In CAR T cell therapies: We utilise single cell multi omics to development a personalized approach to CAR T cell therapies, and dissect the individual variation of the immune responses that can be used to improve treatment and hence precision medicine. 

  5. Immune System Aging: Understanding how the immune system changes with age is another area of interest, as it can shed light on age-related diseases and strategies to enhance immune function in the elderly.