Dr Fernando Santiago

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Journal articles | 2024

Parthasarathy R; Wakefield D; Santiago FS; Kaakoush NO; Tedla N, 2024, 'Horizontal gene transfer and endogenous retroviruses as mechanisms for molecular mimicry', The Lancet Microbe, 5, pp. e4 - e5, http://dx.doi.org/10.1016/S2666-5247(23)00316-6

Journal articles | 2023

Foster CSP; Bull RA; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker GJ; Shrestha LB; Van Hal SJ; Kim KW; Rawlinson WD, 2023, 'Persistence of a Frameshifting Deletion in SARS-CoV-2 ORF7a for the Duration of a Major Outbreak', Viruses, 15, http://dx.doi.org/10.3390/v15020522

Journal articles | 2023

Parthasarathy R; Santiago F; McCluskey P; Kaakoush NO; Tedla N; Wakefield D, 2023, 'The microbiome in HLA-B27-associated disease: implications for acute anterior uveitis and recommendations for future studies', Trends in Microbiology, 31, pp. 142 - 158, http://dx.doi.org/10.1016/j.tim.2022.08.008

Journal articles | 2021

Santiago FS; Li Y; Khachigian LM, 2021, 'Serine 26 in early growth response-1 is critical for endothelial proliferation, migration, and network formation', Journal of the American Heart Association, 10, pp. e020521, http://dx.doi.org/10.1161/JAHA.120.020521

Journal articles | 2021

Santiago FS; Li Y; Zhong L; Raftery MJ; Lins L; Khachigian LM, 2021, 'Truncated YY1 interacts with BASP1 through a ³³⁹KLK³⁴¹motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury', Cardiovascular Research, 117, pp. 2395 - 2406, http://dx.doi.org/10.1093/cvr/cvab021

Journal articles | 2020

Li Y; Alhendi AMN; Yeh MC; Elahy M; Santiago FS; Deshpande NP; Wu B; Chan E; Inam S; Prado-Lourenco L; Marchand J; Joyce RD; Wilkinson-White LE; Raftery MJ; Zhu M; Adamson SJ; Barnat F; Viaud-Quentric K; Sockler J; Mackay JP; Chang A; Mitchell P; Marcuccio SM; Khachigian LM, 2020, 'Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis', Science Advances, 6, pp. eaaz7815, http://dx.doi.org/10.1126/sciadv.aaz7815

Journal articles | 2019

Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019

Journal articles | 2017

Buckler JN; Banwell MG; Kordbacheh F; Parish CR; Santiago FS; Khachigian LM, 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, 2, pp. 7375 - 7388, http://dx.doi.org/10.1021/acsomega.7b01459

Journal articles | 2012

Cai H; Santiago FS; Prado-lourenco L; Wang B; Patrikakis M; Davenport MP; Maghzal GJ; Stocker R; Parish CR; Chong BH; Lieschke GJ; Wong TW; Chesterman CN; Francis DJ; Moloney F; Barnetson R; Halliday GM; Khachigian LM, 2012, 'DNAzyme Targeting c-jun Suppresses Skin Cancer Growth.', Science Translational Medicine, 4, pp. p. 139ra82, http://dx.doi.org/10.1126/scitranslmed.3003960

Journal articles | 2012

Ishii H; Hulett M; Li J; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362

Journal articles | 2010

Beck K; Wu B; Ni J; Santiago FS; Malabanan KP; Li C; Wang Y; Khachigian LM; Stocker R, 2010, 'Interplay between heme oxyhenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia', Circulation Research, 107, pp. 1490 - 1497

Journal articles | 2010

Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010) 185 (1238-1247))', Journal of Immunology, 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092

Journal articles | 2010

Cheng Q; Mckeown S; Santos L; Santiago FS; Khachigian LM; Morand E; Hickey M, 2010, 'Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.', Journal of Immunology, 185, pp. 1238 - 1247

Journal articles | 2010

Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821

Journal articles | 2009

Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J; Stocker R, 2009, 'Abstract: 81 PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE', Atherosclerosis Supplements, 10, pp. e220 - e220, http://dx.doi.org/10.1016/s1567-5688(09)70224-7

Journal articles | 2008

Tan N; Midgley VC; Kavurma MM; Santiago FS; Luo X; Peden RS; Fahmy R; Berndt MC; Molloy M; Khachigian LM, 2008, 'Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific ser/thr residues in the second zinc finger region of Sp1', Circulation Research, 102, pp. E38 - E51, http://dx.doi.org/10.1161/CIRCRESAHA.107.167395

Journal articles | 2007

Khachigian LM; Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin JL; Chesterman CN; Zachary I, 2007, 'Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly', Federation of American Societies for Experimantal Biology Journal, 21, pp. A69 - A69

Journal articles | 2007

Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin J; Chesterman CN; Zachary I; Khachigian LM, 2007, 'Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21(WAF1/Cip1) transcription and p21(WAF1/Cip1)-Cdk4-cyclin D1 assembly', Circulation Research, 101, pp. 146 - 155

Journal articles | 2006

Liu M; Eyries MM; Zhang C; Santiago FS; Khachigian LM, 2006, 'Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1', Blood, 107, pp. 2322 - 2329

Journal articles | 2006

Santiago FS; Ishii H; Hulett MD; Bobik A; Martin JF; Chesterman CN; Zachary IC; Khachigian LM, 2006, 'Injury-inducible yin yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing P21WAF1/CIP1 transcription and perturbing cyclin D1-CDK4-P21WAF1/CIP1 assembly', Vascular Pharmacology, 45, pp. e46 - e47, http://dx.doi.org/10.1016/j.vph.2006.08.160

Journal articles | 2004

Santiago FS; Khachigian LM, 2004, 'Ets-1 Stimulates Platelet-Derived Growth Factor A-Chain Gene Transcription and Vascular Smooth Muscle Cell Growth via Cooperative Interactions With Sp1', Circulation Research, 95, pp. 479 - 487

Journal articles | 2003

De Mestre AM; Khachigian LM; Santiago FS; Staykova MA; Hulett MD, 2003, 'Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1', Journal of Biological Chemistry, 278, pp. 50377 - 50385, http://dx.doi.org/10.1074/jbc.M310154200

Journal articles | 2003

Francis DJ; Parish CR; McGarry M; Santiago FS; Lowe HC; Brown KJ; Bingley JA; Hayward IP; Cowden WB; Campbell JH; Campbell GR; Chesterman CN; Khachigian LM, 2003, 'Blockade of Vascular Smooth Muscle Cell Proliferation and Intimal Thickening After Balloon Injury by the Sulfated Oligosaccharide PI-88', Circulation Research, 92, pp. 70 - 77

Journal articles | 2002

Rafty LA; Santiago FS; Khachigian LM, 2002, 'NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter', European Molecular Biology Organization, 21, pp. 334 - 343

Journal articles | 2001

Kavurma MM; Santiago FS; Bonfoco E; Khachigian LM, 2001, 'Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement', The Journal of Biological Chemistry, pp. 4964 - 4971

Journal articles | 2001

Santiago FS; Khachigian LM, 2001, 'Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.', Molecular Medicine, pp. 695 - 706

Journal articles | 2001

Santiago FS; Lowe HC; Bobryshev YV; Khachigian LM, 2001, 'Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.', The Journal of Biological Chemistry, pp. 41143 - 41149

Journal articles | 2000

Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'A novel catalytic DNA molecule targeting the transcription factor Egr-1 inhibits neointimal formation following rat carotid angioplasty', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35, pp. 15A - 15A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2000

Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'Immobilized hyaluronic acid as a thromboresistant coating for cardiovascular devices', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35, pp. 15A - 15A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 1999

Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.', FASEB JOURNAL, 13, pp. A42 - A42, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033300240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 1999

Khachigian LM; Santiago FS; Rafty LA; Onza CL; Delbridge G; Bobik A; Collins TF; Johnson AG, 1999, 'GC Factor 2 represses plateletderived growth factor Achain gene transcription and is itself induced by arterial injury', Circulation Research, pp. 1258 - 1267

Journal articles | 1999

Santiago FS; Atkins D; Khachigian LM, 1999, 'Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr1/NGFIAdependent.', American Journal of Pathology, 155, pp. 897 - 905

Journal articles | 1999

Santiago FS; Lowe HC; Day FL; Chesterman CN; Khachigian LM, 1999, 'Early growth response factor1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor2.', American Journal of Pathology, 154, pp. 937 - 944

Journal articles | 1999

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'Erratum: New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (Nature Medicine (1999) 5 (1264-1269))', Nature Medicine, 5, pp. 1438, http://dx.doi.org/10.1038/71020

Journal articles | 1999

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (vol 5, pg 1264, 1999)', NATURE MEDICINE, 5, pp. 1438 - 1438, http://dx.doi.org/10.1038/71020

Journal articles | 1999

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker AT; Atkins D; Khachigian LM, 1999, 'New DNA enzyme targeting Egr1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury', Nature Medicine, pp. 1264 - 1269

Journal articles | 1999

Silverman ES; Khachigian LM; Santiago FS; Williams A; Lindner V; Collins TF, 1999, 'Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury.', American Journal of Pathology, 155, pp. 1311 - 1317

Journal articles | 1998

Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1998, 'Endothelial injury triggers FGF-2 release and a signaling cascade involving MAPK and Egr-1.', FASEB JOURNAL, 12, pp. A467 - A467, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006402706&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 1998

Santiago FS; Atkins D; Khachigian LM, 1998, 'Antisense oligonucleotides directed against Egr-1 inhibit vascular smooth muscle cell proliferation.', FASEB JOURNAL, 12, pp. A189 - A189, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006401100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 1997

Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1997, 'Endothelial injury and transcriptional activation: bFGF induction of Egr-1 and PDGF-A', ATHEROSCLEROSIS, 134, pp. 265 - 265, http://dx.doi.org/10.1016/S0021-9150(97)89392-6

Journal articles | 1997

Santiago FS; Todd AV; Hawkins NJ; Ward RL, 1997, 'Detection of K-ras point mutation by enriched PCR-colorimetric plate assay', Molecular and Cellular Probes, 11, pp. 33 - 38

Journal articles | 1997

Ward RL; Todd AV; Santiago FS; O Connor TW; Hawkins NJ, 1997, 'Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis', Cancer, 79, pp. 1106 - 1113

Journal articles | 1995

Ward RL; Santiago FS; Hawkins NJ; Coomber DW; O Connor TW; Todd AV, 1995, 'A rapid PCR ELISA for the detection of activates K-ras in colorectal cancer', Journal of Clinical Pathology, 48, pp. 273 - 277
Preprints | 2022

Foster CSP; Bull R; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker G; Shrestha LB; van Hal S; Kim KW; Rawlinson W, 2022, Persistence of a SARS-CoV-2 variant with a frameshifting deletion for the duration of a major outbreak, , http://dx.doi.org/10.1101/2022.09.06.22279658

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Dr Fernando Santiago