Dr Fiona Knapman

Dr Fiona Knapman

Research Associate
Engineering
Biomedical Engineering

Fiona Knapman is a Postdoctoral Fellow in the School of Biomedical Engineering at UNSW Sydney.

Fiona's research career commenced following her undergraduate studies at the University of Sydney (B.Eng (Biomedical, First Class Honours) / B.Sc (Neuroscience)), when she joined Prof Lynne Bilston's group at NeuRA as a Research Assistant, contributing to large clinical studies investigating obstructive sleep apnoea phenotypes and predictors of oral appliance therapy success. She then pursued her PhD examining the use of optogenetics to restore upper airway muscle function as a therapeutic approach for obstructive sleep apnoea, where current treatments are often limited by poor tolerance and unpredictable efficacy. Fiona continues this work as a Postdoctoral Fellow at UNSW and NeuRA, with the goal of progressing towards clinical translation.

Looking ahead, Fiona's interests lie in applying the optogenetic and gene therapy tools developed through her research more broadly, with the potential to restore neuromuscular function in other conditions where neural control is impaired or lost, such as spinal cord injury and motor neuron disease.

Location
Room 516, Level 5 Samuels Building F25 Kensington Campus
  • Journal articles | 2026
    Burke PGR; Jugé L; Knapman FL; Yeung J; Bull C; Brown EC; Martins R; Gandevia SC; Eckert DJ; Butler JE; Bilston LE, 2026, 'Differential genioglossus muscle responses to changes in breathing route in awake people with and without obstructive sleep apnea', Journal of Applied Physiology, 140, pp. 1487 - 1498, http://dx.doi.org/10.1152/japplphysiol.00588.2025
    Journal articles | 2025
    Jugé L; Burke PGR; Yeung J; Knapman F; Brown EC; Chiang A; Eckert DJ; Butler JE; Bilston LE, 2025, 'Compartmental inspiratory genioglossus electromyographic activity in supine, awake individuals with and without obstructive sleep apnoea', Journal of Physiology, 603, pp. 2877 - 2893, http://dx.doi.org/10.1113/JP287943
    Journal articles | 2025
    Knapman FL; Cohen EM; Kulaga T; Lovell NH; Lisowski L; Burke PGR; Bilston LE, 2025, 'Wild-type and engineered adeno-associated viral vectors produce comparable opsin expression and light-evoked responses in rat skeletal muscle', Molecular Therapy Methods and Clinical Development, 33, pp. 101559, http://dx.doi.org/10.1016/j.omtm.2025.101559
    Journal articles | 2024
    Yeung J; Brown E; Burke P; Jugé L; Knapman F; Chiang A; Eckert D; Butler J; Bilston L, 2024, 'O050 Regional electromyographic activity in genioglossus during quiet breathing in supine, awake individuals with and without sleep apnoea', SLEEP Advances, 5, pp. a18 - a18, http://dx.doi.org/10.1093/sleepadvances/zpae070.050
    Journal articles | 2023
    Cohen EM; Knapman FL; Bilston LE, 2023, 'Optogenetic Control of Muscles: Potential Uses and Limitations', Human Gene Therapy, 34, pp. 416 - 429, http://dx.doi.org/10.1089/hum.2022.236
    Journal articles | 2023
    Jugé L; Liao A; Yeung J; Knapman FL; Bull C; Burke PGR; Brown EC; Gandevia SC; Eckert DJ; Butler JE; Bilston LE; Brown EP, 2023, 'Regional associations between inspiratory tongue dilatory movement and genioglossus activity during wakefulness in people with obstructive sleep apnoea', Journal of Physiology, 601, pp. 5795 - 5811, http://dx.doi.org/10.1113/JP285187
    Journal articles | 2023
    Knapman FL; Cohen EM; Kulaga T; Lovell N; Lisowski L; McMullan S; Burke PGR; Bilston LE, 2023, 'Direct optogenetic activation of upper airway muscles in an acute model of upper airway hypotonia mimicking sleep onset', Sleep, 46, pp. zsad226 - zsad226, http://dx.doi.org/10.1093/sleep/zsad226
    Journal articles | 2022
    Jugé L; Knapman FL; Humburg P; Burke PGR; Lowth AB; Brown E; Butler JE; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2022, 'The relationship between mandibular advancement, tongue movement, and treatment outcome in obstructive sleep apnea', Sleep, 45, pp. zsac044, http://dx.doi.org/10.1093/sleep/zsac044
    Journal articles | 2022
    Yeung J; Burke PGR; Knapman FL; Patti J; Brown EC; Gandevia SC; Eckert DJ; Butler JE; Bilston LE, 2022, 'Task-dependent neural control of regions within human genioglossus', Journal of Applied Physiology, 132, pp. 527 - 540, http://dx.doi.org/10.1152/japplphysiol.00478.2021
    Journal articles | 2021
    Brown EC; Jugé L; Knapman FL; Burke PGR; Ngiam J; Sutherland K; Butler JE; Eckert DJ; Cistulli PA; Bilston LE, 2021, 'Mandibular advancement splint response is associated with the pterygomandibular raphe', Sleep, 44, pp. zsaa222, http://dx.doi.org/10.1093/sleep/zsaa222
    Journal articles | 2021
    Jugé L; Olsza I; Knapman FL; Burke PGR; Brown EC; Stumbles E; De Frescheville AFB; Gandevia SC; Eckert DJ; Butler JE; Bilston LE, 2021, 'Effect of upper airway fat on tongue dilation during inspiration in awake people with obstructive sleep apnea', Sleep, 44, pp. zsab192, http://dx.doi.org/10.1093/sleep/zsab192
    Journal articles | 2021
    Jugé L; Yeung J; Knapman FL; Burke PGR; Lowth AB; Gan KZC; Brown EC; Butler JE; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2021, 'Influence of mandibular advancement on tongue dilatory movement during wakefulness and how this is related to oral appliance therapy outcome for obstructive sleep apnea', Sleep, 44, pp. zsaa196, http://dx.doi.org/10.1093/sleep/zsaa196
    Journal articles | 2021
    Sutherland K; Almeida FR; Kim T; Brown EC; Knapman F; Ngiam J; Yang J; Bilston LE; Cistulli PA, 2021, 'Treatment usage patterns of oral appliances for obstructive sleep apnea over the first 60 days: a cluster analysis.', J Clin Sleep Med, 17, pp. 1785 - 1792, http://dx.doi.org/10.5664/jcsm.9288
    Journal articles | 2020
    Burke PGR; Carter SG; Knapman F; Patti J; Butlin M; Gandevia SC; Butler JE; Eckert DJ; Bilston LE, 2020, 'Nocturnal swallowing augments arousal intensity and arousal tachycardia', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 8624 - 8632, http://dx.doi.org/10.1073/pnas.1907393117
    Journal articles | 2020
    Jugé L; Knapman FL; Burke PGR; Brown E; Bosquillon de Frescheville AF; Gandevia SC; Eckert DJ; Butler JE; Bilston LE, 2020, 'Regional respiratory movement of the tongue is coordinated during wakefulness and is larger in severe obstructive sleep apnoea', Journal of Physiology, 598, pp. 581 - 597, http://dx.doi.org/10.1113/JP278769
    Journal articles | 2019
    Tong J; Juge L; Burke PGR; Knapman F; Eckert DJ; Bilston LE; Amatoury J, 2019, 'Respiratory-related displacement of the trachea in obstructive sleep apnea', Journal of Applied Physiology, 127, pp. 1307 - 1316, http://dx.doi.org/10.1152/japplphysiol.00660.2018
  • Conference Abstracts | 2024
    Knapman F; Cohen E; Kulaga T; Lovell N; Lisowski L; McMullan S; Burke PGR; Bilston L, 2024, 'An Optogenetics-based Therapy for Obstructive Sleep Apnea', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, CA, San Diego, Vol. 209, presented at International Conference of the American-Thoracic-Society (ATS), CA, San Diego, 17 May 2024 - 22 May 2024
    Conference Abstracts | 2024
    Knapman F; Cohen M; Rail K; Turner A; Swain R; Kulaga T; Lovell N; Lisowski L; Shklovskaya E; Burke P; Bilston L, 2024, 'O049 Maintaining long-term functional optogenetic stimulation for OSA therapy in a rodent model', in SLEEP Advances, Oxford University Press (OUP), Gold Coast, QLD Australia, Vol. 5, pp. a18 - a18, presented at Sleep DownUnder 2024, Gold Coast, QLD Australia, 16 October 2024 - 19 October 2024, http://dx.doi.org/10.1093/sleepadvances/zpae070.049
    Conference Abstracts | 2024
    Knapman FL; Cohen EM; Kulaga T; Lovell N; Lisowski L; McMullan S; Burke PGR; Bilston LE, 2024, 'An Optogenetics-Based Gene Therapy for Obstructive Sleep Apnea', in MOLECULAR THERAPY, CELL PRESS, MD, Baltimore, Vol. 32, pp. 217 - 218, presented at 27th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), MD, Baltimore, 07 May 2024 - 11 May 2024
    Conference Papers | 2023
    Jugé L; Liao A; Yeung J; Knapman F; Bull C; Burke P; Brown E; Gandevia S; Eckert D; Butler J; Bilston L, 2023, 'Inspiratory dilatory tongue movement, as measured with tagged MRI, and intramuscular neural drive in obstructive sleep apnoea patients', in ISMRM Annual Meeting, ISMRM, presented at 2023 ISMRM & ISMRT Annual Meeting, 03 June 2023 - 08 June 2023, http://dx.doi.org/10.58530/2023/1443
    Conference Abstracts | 2022
    Jugé L; Liao A; Yeung J; Knapman F; Burke P; Brown E; Gandevia S; Eckert D; Butler J; Bilston L, 2022, 'O054 Genioglossus neural drive and upper airway dilation in people with obstructive sleep apnoea during wakefulness', in SLEEP Advances, Oxford University Press (OUP), Vol. 3, pp. A23 - A23, http://dx.doi.org/10.1093/sleepadvances/zpac029.053
    Conference Abstracts | 2022
    Knapman F; Cohen M; Kulaga T; Lisowski L; Lovell N; McMullan S; Burke P; Bilston L, 2022, 'O002 A novel, optogenetics based therapy for obstructive sleep apnea', in SLEEP Advances, Oxford University Press (OUP), Brisbane, QLD Australia, Vol. 3, pp. a1 - a1, presented at Sleep DownUnder 2022, Brisbane, QLD Australia, 08 November 2022 - 11 November 2022, http://dx.doi.org/10.1093/sleepadvances/zpac029.001
    Conference Abstracts | 2021
    Jugé L; Knapman F; Humburg P; Burke P; Lowth A; Brown E; Butler J; Eckert D; Ngiam J; Sutherland K; Cistulli P; Bilston L, 2021, 'Pharyngeal enlargement via tongue advancement differs with mandibular advancement therapy response and improves treatment prediction', in SLEEP Advances, Oxford University Press (OUP), Vol. 2, pp. A11 - A12, http://dx.doi.org/10.1093/sleepadvances/zpab014.025
    Conference Abstracts | 2021
    Knapman F; Burke P; Cohen M; McMullan S; Bilston L, 2021, 'P063 Optogenetics for Obstructive Sleep Apnea', in SLEEP Advances, Oxford University Press (OUP), Vol. 2, pp. A42 - A42, http://dx.doi.org/10.1093/sleepadvances/zpab014.109
    Conference Abstracts | 2020
    Bilston L; Juge L; Knapman F; Yeung J; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA, 2020, 'Mandibular Advancement Splint Treatment Outcome Is Related to the Interaction Between Airway Enlargement and Dilatory Muscle Function with Mandibular Advancement', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, ELECTR NETWORK, Vol. 201, presented at International Conference of the American-Thoracic-Society (ATS), ELECTR NETWORK, 10 November 2020
    Conference Abstracts | 2020
    Burke PG; Carter SG; Knapman F; Patti J; Butlin M; Gandevia SC; Butlers J; Eckert DJ; Bilston L, 2020, 'Nocturnal Swallowing Augments Arousal Intensity and Arousal Tachycardia in Healthy Individuals and in Obstructive Sleep Apnea', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, ELECTR NETWORK, Vol. 201, presented at International Conference of the American-Thoracic-Society (ATS), ELECTR NETWORK, 10 November 2020
    Conference Abstracts | 2020
    Osman A; Burke P; Knapman F; Carberry J; Butler J; Bilston L; Eckert DJ, 2020, 'Mandibular Advancement Splint Improves Upper Airway Collapsibility Without Changing Genioglossus Reflex Responses In People With Obstructive Sleep Apnea During Wakefulness', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, ELECTR NETWORK, Vol. 201, presented at International Conference of the American-Thoracic-Society (ATS), ELECTR NETWORK, 10 November 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000556622802498&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Juge L; Yeung J; Knapman F; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2019, 'Altered inspiratory airway dilation patterns with mandibular advancement splints may help predict treatment outcomes', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Sydney, Vol. 28, presented at 31st Annual Scientific Meeting (ASM) of the Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Sydney, 16 October 2019 - 19 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489047200032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Juge L; Yeung J; Knapman F; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2019, 'HOW MANDIBULAR ADVANCEMENT SPLINTS ALTER GENIOGLOSSUS AIRWAY DILATION PATTERNS DURING INSPIRATION IN AWAKE PEOPLE WITH OBSTRUCTIVE SLEEP APNOEA MAY HELP PREDICT TREATMENT OUTCOMES', in SLEEP MEDICINE, ELSEVIER, Vol. 64, pp. S38 - S38
    Conference Abstracts | 2019
    Sutherland K; Almeida FR; Kim T; Brown E; Knapman F; Lowth AB; Ngiam J; Yang J; Bilston LE; Cistulli PA, 2019, 'Treatment usage patterns across the first 60 days of oral appliance therapy: A cluster analysis', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Sydney, Vol. 28, presented at 31st Annual Scientific Meeting (ASM) of the Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Sydney, 16 October 2019 - 19 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489047200076&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Burke P; Knapman F; Tong B; Brown E; Sutherland K; Cistulli P; Juge L; Butler J; Eckert D; Bilston L, 2018, 'Effects of Mandibular Advancement Splints on upper airway physiology in obstructive sleep apnoea', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Brisbane, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    George V; Burke P; Brown E; Knapman F; Eckert D; Bilston L; Butler J, 2018, 'MOTOR UNIT RECRUITMENT IN HUMAN GENIOGLOSSUS DURING FLOW-LIMITED BREATHING IN SLEEP', in RESPIROLOGY, WILEY, Vol. 23, pp. 312 - 312, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456217200834&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Juge L; Knapman F; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2018, 'Can Tongue Deformation During Mandibular Advancement Help to Predict Mandibular Advancement Treatment Outcomes?', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, CA, San Diego, Vol. 197, presented at International Conference of the American-Thoracic-Society, CA, San Diego, 18 May 2018 - 23 May 2018
    Conference Abstracts | 2018
    Juge L; Knapman F; Burke P; Brown E; Gandevia S; Eckert D; Butler J; Bilston L, 2018, 'Variation in horizontal and oblique genioglossus dilatory motion during inspiration in obstructive sleep apnoea', in Journal of Sleep Research, Wiley, AUSTRALIA, Brisbane, Vol. 27, pp. e58_12765, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018, http://dx.doi.org/10.1111/jsr.58_12765
    Conference Abstracts | 2018
    Juge L; Knapman F; Eckert D; Burke P; Brown E; Butler J; Ngiam J; Sutherland K; Cistulli P; Bilston L, 2018, 'Tongue deformation during mandibular advancement may help to predict mandibular advancement treatment outcome in obese patients with obstructive sleep apnoea', in Journal of Sleep Research, Wiley, AUSTRALIA, Brisbane, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018, http://dx.doi.org/10.1111/jsr.36_12765
    Conference Abstracts | 2018
    Lowth A; Juge L; Knapman F; Burke P; Brown E; Butler J; Eckert D; Ngiam J; Cistulli P; Bilston L; Sutherland K, 2018, 'Dynamic MRI tongue deformation patterns during mandibular advancement and associations with craniofacial anatomy in OSA', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Brisbane, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018
    Conference Abstracts | 2017
    Zheng Y; Burke P; Knapman F; Brown E; Eckert D; Butler J; Bilston L; Butler J, 2017, 'REGIONAL NEURAL CONTROL OF GENIOGLOSSUS IN WAKE AND SLEEP', in Respirology, Wiley, Vol. 22, pp. 38 - 38, http://dx.doi.org/10.1111/resp.13206_90