Dr Frances Louise Byrne
Senior Lecturer

Dr Frances Louise Byrne

Bachelor of Biotechnology (Hons), Flinders University, South Australia

PhD, Paediatric Oncology, Children's Cancer Institute, New South Wales

Science
School of Biotech & Biomolecular Science

Professional Awards and Experience

2022-2024            Cancer Institute NSW Career Development Fellow (UNSW)

2021                       Associate Fellow (AFHEA) Advance Higher Education

2021                       Researcher Exchange and Development within Industry (REDI) Fellow

2020                       Bridge Program participant

2018-2021            Cancer Institute NSW Early Career Fellow (UNSW)

2014-2017          Hope Funds for Cancer Research Postdoctoral Fellow (UVA/UNSW)

2012-2014          Postdoctoral Research Associate, University of Virginia (USA)

2008-2012          Anthony Rothe Memorial Trust PhD Scholar, Children’s Cancer Institute (UNSW)

2005-2008          Research Assistant, Children’s Cancer Institute (UNSW)

2002-2005          Methods Development Scientist, GroPep Bioreagents (Adelaide)

1999-2003          Bachelor of Biotechnology (Hons), Flinders University of South Australia

 

Research Metrics

38 publications (8 first author, 3 senior author, 2 commentaries, 1 book chapter)

h-index 20, citations >1,600 (source Google Scholar)

 

Research Focus

Dr Byrne was awarded her PhD in 2012 for her research that discovered how a cytoskeletal protein (stathmin) promotes metastasis in the aggressive childhood cancer, neuroblastoma (Byrne et al. 2014, Oncogene). Dr Byrne then trained as a postdoc at the University of Virginia (USA) from 2012-2014 where she studied cancer cell metabolism and the pathophysiology of obesity-related cancers (Byrne et al. 2014, Cancer Research). She returned to Australia in 2014 to the School of Biotechnology & Biomolecular Sciences (UNSW), and now leads a team of students (PhD, honours, and undergraduates) and a research assistant, and has established strong national and international collaborations with other leading researchers, gynaecological oncologists, gastroenterologists, pathologists, and medicinal chemists.

 

She has 3 major research interests:

Research Project 1: Developing new anti-cancer drugs that target cell metabolism

Dr Byrne performed a drug screen that identified a small molecule (BH10) that induces mitochondrial oxidative stress and has better cancer cell-specific toxicity than many chemotherapy agents (Byrne et al. 2020, Redox Biology). This research initiated a project which aims to develop new and improved BH10-like molecules in collaboration with medicinal chemist, Professor Naresh Kumar (Chemistry, UNSW). Dr Byrne is also working with Professor Kyle Hoehn and Continuum Biosciences/Life Biosciences to investigate the therapeutic potential of mitochondrial uncouplers in cancer.

Research Project 2: Investigating a new drug target for endometrial cancer

Cancer of the cells lining the uterus (endometrial cancer) is the most common gynaecological cancer in the Western world and the incidence of this cancer is on the rise in Australia and the US. Dr Byrne identified a new drug target for endometrial cancer, the glucose transporter GLUT6 (Byrne et al. 2014, Cancer Research). Her research was the first to show that GLUT6 plays an important role in endometrial cancer cells by regulating glucose metabolism and cell survival. Dr Byrne then developed and phenotyped the first GLUT6 knockout mouse and showed that loss of GLUT6 is not detrimental to mice (Byrne et al. 2018, Am J Physiol Endocrinol Metab). This research suggests that GLUT6 may be a good target for cancer therapy because loss of this protein may not affect healthy tissues. Future research on this project will investigate the impact of over-expressing GLUT6 in normal and cancerous endometrial cells, as this may provide clues as to how up-regulation of GLUT6 benefits the growth of endometrial cancers.

Research Project 3: Unravelling the links between diet, obesity, and cancer

Cancers of the liver and uterus (endometrium) are strongly linked to poor diet and obesity. Dr Byrne’s research has shown that endometrial cancers rely on glucose metabolism (glycolysis) to survive (Byrne et al. 2014, Cancer Research). This study and that of others were the focus of a recent review she co-authored (Byrne et al. 2020, Cancers). Dr Byrne and her team are now conducting multi-omic studies on patient samples from women with and without endometrial cancer. This includes a new area of research investigating the links between obesity, uterine microbiota, and endometrial cancer.

Dr Byrne also uses a carcinogen-induced mouse model of liver tumorigenesis to study how different diets and obesity influence the development of liver cancer. Dr Byrne's research has shown that feeding mice ketogenic diet does not alter the growth of established liver tumours (Byrne et al. 2018, Cancers). Her lab is currently investigating the links between dietary fructose and liver tumorigenesis in this model.

Contribution to Profession

Dr Byrne reviews fellowship applications (Hope Funds for Cancer Research), NHMRC grants, HDR student theses, and manuscripts for Cancer Research, IJMS, AJP Endocrinology & Metabolism, Scientific Reports, International Journal of Molecular Sciences, Endocrine-Related Cancer, Journal of Pathology, Biomed Research International, Cellular Signalling, Cells, Cancers, etc. She also serves on the Honours Committee for BABS and helps organise and chair sessions at national conferences.

Teaching

Dr Byrne is an Associate Fellow of Advance Higher Education (AFHEA) and enjoys engaging with students through lectures, one-on-one supervision in her lab, the Talented Students Program (BABS), and at Careers Night run by BABSOC. She lectures in BABS3151 (topic: Cancer Genetics), BIOC3271/3671 (topic: Molecular Approaches to Cancer Cell Biology), BIOC3261 (topic: Cancer Metabolism), and co-convenes BABS2011 (Current Trends in Biotechnology). She supervises PhD, honours, and undergraduate students (SCIF2041/3041, BABS3301, BIOC3671) in BABS, and co-supervises honours/MPhil students in Chemistry. She also regularly co-supervises and mentors Independent Learning Project (ILP), honours, and PhD students in the School of Medicine. Dr Byrne has research projects suited to honours and PhD students in the 3 main areas of her research (listed above).  

Social Engagement & Equity

Co-chair of the Executive Committee for the Women in Research Network (WiRN) (2022-2023), Faculty of Science representative (2021-2023). Dr Byrne is passionate about wanting to ensure UNSW is a workplace where women (cis and trans) are treated fairly and have equal opportunities. She aims to promote this network to women that are new to UNSW, particularly ECRs and EMCRs, who might not feel that they have proper support and know what opportunities exist for them as they progress in their career.

Engagement with consumers. Dr Byrne recognizes the importance of communicating her cancer research with the wider community. She has developed strong relationships with consumers, including Mr Jeff Cuff whose sadly lost his wife colon cancer in 2013. In addition to his role as a research advocate, Jeff has also been an active member of Dr Byrne’s laboratory because he has a keen interest in scientific research (see Jeff's profile here). Jeff’s contributions led to co-authorship in Dr Byrne’s publication (Byrne et al, 2020 Redox Biology) and he continues to play an important role in guiding her research and helping her establish new collaborations with cancer researchers.

Phone
02 9065 1211
Location
UNSW Level 4, D26 Biological Sciences Building Kensington 2052 Australia
  • Book Chapters | 2012
    Ng DCH; Byrne FL, 2012, 'Stathmin and Cancer', in Kavallaris M (ed.), Cytoskeleton and Human Disease, Humana Press, http://dx.doi.org/10.1007/978-1-61779-788-0_14
  • Journal articles | 2022
    Byrne FL; Olzomer EM; Lolies N; Hoehn KL; Wegner M-S, 2022, 'Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma', International Journal of Molecular Sciences, vol. 23, pp. 4477 - 4477, http://dx.doi.org/10.3390/ijms23094477
    Journal articles | 2022
    Sumer-Bayraktar Z; Fife CM; Byrne FL; Kavallaris M; Packer NH, 2022, 'Membrane glycome is impacted by the cell culturing mode of neuroblastoma cells with differing migration and invasion potential.', Glycobiology, http://dx.doi.org/10.1093/glycob/cwac016
    Journal articles | 2021
    Shrestha R; Johnson E; Byrne FL, 2021, 'Exploring the therapeutic potential of mitochondrial uncouplers in cancer', Molecular Metabolism, vol. 51, http://dx.doi.org/10.1016/j.molmet.2021.101222
    Journal articles | 2021
    Wegner MS; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, 'Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells', Cellular and Molecular Life Sciences, vol. 78, pp. 7025 - 7041, http://dx.doi.org/10.1007/s00018-021-03958-9
    Journal articles | 2020
    Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, vol. 11, pp. 2397, http://dx.doi.org/10.1038/s41467-020-16298-2
    Journal articles | 2020
    Byrne FL; Martin AR; Kosasih M; Caruana BT; Farrell R, 2020, 'The role of hyperglycemia in endometrial cancer pathogenesis', Cancers, vol. 12, http://dx.doi.org/10.3390/cancers12051191
    Journal articles | 2020
    Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, vol. 28, pp. 101374 - 101374, http://dx.doi.org/10.1016/j.redox.2019.101374
    Journal articles | 2020
    Flynn MC; Kraakman MJ; Tikellis C; Lee MKS; Hanssen NMJ; Kammoun HL; Pickering RJ; Dragoljevic D; Al-Sharea A; Barrett TJ; Hortle F; Byrne FL; Olzomer E; McCarthy DA; Schalkwijk CG; Forbes JM; Hoehn K; Makowski L; Lancaster GI; El-Osta A; Fisher EA; Goldberg IJ; Cooper ME; Nagareddy PR; Thomas MC; Murphy AJ, 2020, 'Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis', Circulation Research, vol. 127, pp. 877 - 892, http://dx.doi.org/10.1161/CIRCRESAHA.120.316653
    Journal articles | 2020
    Hegarty KJ; Byrne FL, 2020, 'Comment on “differential effects of mitovite, α-tocopherol and trolox on oxidative stress, mitochondrial function and inflammatory signalling pathways in endothelial cells cultured under conditions mimicking sepsis, antioxidants 2020, 9(3), 195”', Antioxidants, vol. 9, http://dx.doi.org/10.3390/antiox9060462
    Journal articles | 2020
    Caruana BT; Byrne FL, 2020, 'The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer', Cellular Signalling, vol. 73, http://dx.doi.org/10.1016/j.cellsig.2020.109688
    Journal articles | 2020
    Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, vol. 10, pp. 8182, http://dx.doi.org/10.1038/s41598-020-65182-y
    Journal articles | 2019
    Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, vol. 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7
    Journal articles | 2019
    Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, pp. 728 - 739, http://dx.doi.org/10.1080/14756366.2019.1580276
    Journal articles | 2019
    Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, vol. 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063
    Journal articles | 2018
    Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth', Cancers, vol. 10, http://dx.doi.org/10.3390/cancers10090312
    Journal articles | 2018
    Namivandi-Zangeneh R; Kwan RJ; Nguyen TK; Yeow J; Byrne FL; Oehlers SH; Wong EHH; Boyer C, 2018, 'The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers', Polymer Chemistry, vol. 9, pp. 1735 - 1744, http://dx.doi.org/10.1039/c7py01069a
    Journal articles | 2018
    Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, vol. 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534
    Journal articles | 2018
    Namivandi-Zangeneh R; Kwan RJ; Thuy-Khanh N; Yeow J; Byrne FL; Oehlers SH; Wong EHH; Boyer C, 2018, 'The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers (vol 9, pg 1735, 2017)', POLYMER CHEMISTRY, vol. 9, pp. 1745 - 1745, http://dx.doi.org/10.1039/c7py90140b
    Journal articles | 2018
    Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', ESMO Open, vol. 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56
    Journal articles | 2018
    Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, vol. 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018
    Journal articles | 2017
    Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, vol. 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006
    Journal articles | 2017
    Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms14689
    Journal articles | 2017
    Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, vol. 56, pp. 528 - 537, http://dx.doi.org/10.1007/s12020-017-1297-2
    Journal articles | 2017
    Fife CM; Sagnella SM; Teo WS; Po'uha ST; Byrne FL; Yeap YY; Ng DC; Davis TP; McCarroll JA; Kavallaris M, 2017, 'Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.', Oncogene, vol. 36, pp. 501 - 511, http://dx.doi.org/10.1038/onc.2016.220
    Journal articles | 2016
    Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, vol. 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005
    Journal articles | 2016
    Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep22292
    Journal articles | 2016
    McCarroll JA, 2016, 'Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration', Oncogene, vol. 36, pp. 501 - 511, http://dx.doi.org/10.1038/onc.2016.220.
    Journal articles | 2016
    Byrne FL; McCarroll JA; Kavallaris M, 2016, 'Analyses of tumor burden in vivo and metastasis ex vivo using luciferase-expressing cancer cells in an orthotopic mouse model of neuroblastoma', RNA imaging: methods and protocols, vol. 1372, pp. 61 - 77, http://dx.doi.org/10.1007/978-1-4939-3148-4_5
    Journal articles | 2016
    Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, vol. 239, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702
    Journal articles | 2016
    Baker W; Paquette C; Byrne FL; Atkins KA; Shupnik M; Modesitt SC; Hoehn KL; Slack-Davis JK, 2016, 'Postmenopausal endometrial cancer patients have significantly higher expression of GLUT6 in the endometrium', Gynecologic Oncology, vol. 141, pp. 175 - 176, http://dx.doi.org/10.1016/j.ygyno.2016.04.456
    Journal articles | 2015
    Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
    Journal articles | 2015
    Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, vol. 57, pp. 537 - 551, http://dx.doi.org/10.1016/j.molcel.2015.01.002
    Journal articles | 2015
    Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, vol. 62, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024
    Journal articles | 2015
    McCarroll JA; Gan PP; Erlich RB; Liu M; Dwarte T; Sagnella SS; Akerfeldt MC; Yang L; Parker AL; Chang MH; Shum MS; Byrne FL; Kavallaris M, 2015, 'TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer', Cancer Research, vol. 75, pp. 415 - 425, http://dx.doi.org/10.1158/0008-5472.CAN-14-2740
    Journal articles | 2014
    Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, vol. 74, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254
    Journal articles | 2014
    Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, vol. 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004
    Journal articles | 2014
    Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, vol. 3, pp. 114 - 123, http://dx.doi.org/10.1016/j.molmet.2013.11.005
    Journal articles | 2014
    Byrne FL; Yang L; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2014, 'RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model', Oncogene, vol. 33, pp. 882 - 890, http://dx.doi.org/10.1038/onc.2013.11
    Journal articles | 2013
    Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2013.11.005
    Journal articles | 2011
    Gan PP; Mccarroll J; Byrne F; Garner J; Kavallaris M, 2011, 'Specific beta-Tubulin Isotypes Can Functionally Enhance or Diminish Epothilone B Sensitivity in Non-Small Cell Lung Cancer Cells', PLoS One, vol. 6, pp. e21717, http://dx.doi.org/10.1371/journal.pone.0021717
    Journal articles | 2010
    Abraham G; McCaroll J; Byrne F; Saricilar S; Kavallaris M; Bulmus V, 2010, 'Block Co-polymer Nanoparticles with Degradable Cross-Linked Core and Low-Molecular-Weight PEG Corona for Anti-tumour Drug Delivery', Journal of Biomaterials Science - Polymer Edition, vol. 22, pp. 1001 - 1022, http://dx.doi.org/10.1163/092050610X497872
    Journal articles | 2008
    Chan YK; Wong TH; Byrne F; Kavallaris M; Bulmus V, 2008, 'Acid-labile core cross-linked micelles for pH-triggered release of antitumor drugs.', Biomacromolecules, vol. 9, pp. 1826 - 1836, http://dx.doi.org/10.1021/bm800043n
    Journal articles | 2006
    Chan YK; Bulmus V; Zareie MH; Barner L; Kavallaris M; Byrne F, 2006, 'Acid-Cleavable polymeric core-shell particles for delivery of hydrophoblic drugs', Journal of Controlled Release, vol. 115, pp. 197 - 207, http://dx.doi.org/10.1016/j.jconrel.2006.07.025
  • Conference Papers | 2014
    McCarroll JA; Gan PP; Erlich RB; Liu M; Dwarte T; Akerfeldt MC; Chang M; Shum MS; Byrne F; Kavallaris M, 2014, 'beta III-tubulin is required for the tumorigenic phenotype and resistance to anoikis via the PTEN/AKT signaling axis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Diego, CA, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-2076
    Conference Papers | 2014
    Fife CM; Byrne FL; Sagnella SM; Davis TP; McCarroll JA; Kavallaris M, 2014, 'Stathmin regulates cell migration, invasion and transendothelial migration via RhoA activation in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Diego, CA, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-4987
    Conference Abstracts | 2012
    Byrne FL; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2012, 'Stathmin suppression influences ROCK signaling and reduces cell invasion and metastasis in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1444
    Theses / Dissertations | 2012
    Byrne FL, 2012, Investigation of stathmin's role in neuroblastoma drug resistance, differentiation and metastasis, University of New South Wales, Children's Cancer Institute
    Conference Papers | 2010
    Byrne FL; McCarroll J; Kavallaris M, 2010, 'Abstract 5141: Stathmin mediates neuroblastoma migration and invasion via regulation of the actin network', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am10-5141
    Conference Papers | 2010
    McCarroll JA; Gan PP; Liu M; Dwarte T; Chang M; Byrne F; Kavallaris M, 2010, 'beta III-Tubulin regulates expression of proteins involved in tumorigenesis and metastasis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM10-5026
    Preprints |
    Byrne F; Olzomer E; Lolies N; Hoehn KL; Wegner M-S, Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma, http://dx.doi.org/10.20944/preprints202203.0309.v1
    Preprints |
    Wegner M-S; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells, http://dx.doi.org/10.21203/rs.3.rs-454533/v1

Fellowships/Scholarships/Funding

Cancer Institute NSW Career Development Fellowship (2022-2024)

Researcher Exchange & Development within Industry (REDI) Fellowship (2021)

Cancer Institute NSW Early Career Fellowship (2018-2021)

UNSW Career Advancement Fund (2019)

Translational Cancer Research Network (TCRN) grant (2018)

Next Generation Sequencing Grant, UNSW (2018)

Conference and Professional Development Grant, TCRN (2017)

Early Career Researcher Grant, Faculty of Science, UNSW (2016)

Hope Funds for Cancer Research Postdoctoral Fellowship (2014-2017) (USA), Malcolm AS Moore Honorary Fellow

Anthony Rothe Memorial PhD Scholarship (2008-2011)

Louiza Zervos Memorial Scholarship in Paediatrics (2010)

  • Paper of the Month for publication in Redox Biology, School of Biotechnology and Biomolecular Sciences, UNSW (2019)
  • Best oral presentation at AussieMit conference, Harry Perkins Institute of Medical Research, Perth, WA (2014)
  • Australian Mitochondrial Disease Foundation Travel Grant, AussieMit conference, Perth, WA (2014)
  • Paper of the Month for publication in Cancer Research, School of Biotechnology and Biomolecular Sciences, UNSW, Australia (2014)
  • Sydney Catalyst Prize for best cancer-related poster, Annual Garvan Signalling Symposium, Sydney, Australia (2014)
  • Jefferson Cup awarded for oral presentation at the UVA Postdoctoral Research Day, University of Virginia (USA) (2014)
  • Poster prize at the Inaugural UVA Postdoctoral Research Day, University of Virginia (USA) (2013)
  • University of Sydney Medal for Best Overall Presentation, ASMR Medical Research Week NSW Scientific Meeting (2011)