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Dr George Sharbeen

Dr George Sharbeen

Senior Research Fellow
Medicine & Health
Pathology

Dr George Sharbeen is co-lead of the Pancreatic Cancer Translational Research Group (UNSW Sydney) and a senior research fellow in the Poor Outcomes Cancers focus area, within the Sydney Partnership for Health, Education, Research and Enterprise [SPHERE] Cancer Clinical Academic Group. His research is focused on developing more effective therapies for pancreatic cancer and his most notable achievements include co-development of a novel nanomedicine for pancreatic cancer and a 3D human pancreatic cancer explant model, and the identification of an amino acid transporter as a stromal remodelling target in pancreatic cancer. His work formed the foundation for the SPEAR (Sulfasalazine in patients with PancrEatic AdenocaRcinoma) clinical trial (part of the Molecular Screening and Therapeutics [MoST] pancreas cancer program) where Dr Sharbeen co-leads the correlative science studies. His research success has been recognised by a number of awards and competitive research funding including Cancer-Institute NSW Early-Career and Mid-Career Fellowships. He is currently funded by Pankind Accelerator and NSW Health Advanced Therapeutics Impact grants.
E-mail
g.sharbeen@unsw.edu.au
Location
Pancreatic Cancer Translational Research Group, Level 2, Lowy Cancer Research Centre, School of Biomedical Sciences
  • Book Chapters | 2024
    Kokkinos J; Sharbeen G; Phillips PA, 2024, 'Management of Primary Pancreatic Cancer', in Jankowski JAZ (ed.), Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach, Wiley, pp. 386 - 406, http://dx.doi.org/10.1002/9781119756422.ch20
    Book Chapters | 2019
    McCarroll JA; Sharbeen G; Kavallaris M; Phillips PA, 2019, 'The use of star polymer nanoparticles for the delivery of siRNA to mouse orthotopic pancreatic tumor models', in RNA interference and cancer therapy : methods and protocols, pp. 329 - 353, http://dx.doi.org/10.1007/978-1-4939-9220-1_23
    Book Chapters | 2015
    Sharbeen G; McAlpine SR; Phillips P, 2015, 'HSP47: The New Heat Shock Protein Therapeutic Target', in Topics in Medicinal Chemistry, Springer Berlin Heidelberg, http://dx.doi.org/10.1007/7355_2015_89
  • Journal articles | 2026
    Liu Y; Khosravi F; Yeo D; Söderström B; El-Helou AJ; Reece PJ; Sharbeen G; Phillips PA; Zhu Y, 2026, 'Unlocking the Potentials of Single Extracellular Vesicle Analysis Technologies for Early Detection of Pancreatic Cancer', ACS Nano Medicine, http://dx.doi.org/10.1021/acsnanomed.5c00113
    Journal articles | 2026
    Sharbeen G; Kokkinos J; Schulstad G; Pandzic E; Youkhana J; Ma Z; Ignacio RMC; Raina AS; Chiang S; Boyer C; Haghighi KS; Gunawarman M; Goldstein D; Gebski V; Pajic M; Davis ME; Arkell OSM; Kopecky C; Gonzales-Aloy E; Ishak A; Erkan M; Morton JP; Kavallaris M; Gunning PW; Hardeman EC; Johns A; Gill AJ; Whan RM; Mawson A; Pitiyarachchi O; Australian Pancreatic Cancer Genome Initiative ; McCarroll JA; Phillips PA, 2026, 'βIII-tubulin can act as a brake on extrinsic apoptosis in pancreatic cancer.', Cell Death Dis, http://dx.doi.org/10.1038/s41419-026-08657-6
    Journal articles | 2026
    Wade SJ; Kumar AA; Nitschke SO; Joyce P; Minaei E; Reuter Lange SE; Penney C; Warren H; Shepherd R; Dinoro JN; Wallace GG; Dosseto A; Ansar S; Islam N; Lochhead A; Sharbeen G; Phillips PA; Aghmesheh M; Hawthorne WJ; Vine-Perrow KL, 2026, 'Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy', Advanced Materials, http://dx.doi.org/10.1002/adma.202522617
    Journal articles | 2025
    Chiang S; Garcia Netto K; Kokkinos J; Haghighi KS; Raina AS; Youkhana J; Pitiyarachchi O; Truong Q; Wenholz D; Wilkinson J; Laczka O; Li X; Aldilla VR; Kumar N; Goldstein D; Sharbeen G; Phillips PA, 2025, 'CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts', Scientific Reports, 15, http://dx.doi.org/10.1038/s41598-025-09411-2
    Journal articles | 2025
    Ephraums J; Youkhana J; Raina AS; Schulstad G; Croft K; Mawson A; Kokkinos J; Gonzales-Aloy E; Ignacio RMC; McCarroll JA; Boyer C; Goldstein D; Pajic M; Haghighi KS; Johns A; Gill AJ; Erkan M; Initiative (APGI) APCG; Phillips PA; Sharbeen G, 2025, 'MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability', Neoplasia United States, 61, http://dx.doi.org/10.1016/j.neo.2025.101138
    Journal articles | 2025
    Ignacio RMC; Forgham H; Ma Z; Jensen A; Sharbeen G; Ruan J; Ziegler DS; Tsoli M; Phillips PA; Mayoh C; Kavallaris M; McCarroll J, 2025, 'Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells', Cell Communication and Signaling, 23, http://dx.doi.org/10.1186/s12964-025-02241-9
    Journal articles | 2025
    Lin FP-Y; Goldstein D; Grady JP; Napier C; Thavaneswaran S; Pitiyarachchi O; Kansara M; Chantrill LA; Sjoquist K; Thornton K; Raina A; Magenau A; Simes J; Ballinger ML; Sharbeen G; Timpson P; Pajic M; Phillips P; Thomas DM, 2025, 'Genomic and outcome analysis of recurrent versus de novo metastatic pancreatic ductal adenocarcinoma (PDAC) receiving systemic therapy: Results from the Australian MoST and CaSP screening programs.', JOURNAL OF CLINICAL ONCOLOGY, 43, pp. 4120 - 4120, http://dx.doi.org/10.1200/JCO.2025.43.16_suppl.4120
    Journal articles | 2025
    Schulstad G; Kokkinos J; Youkhana J; Raina AS; Davis ME; Arkell OSM; Netto KG; Boyer C; Goldstein D; Haghighi KS; Sharbeen G; McCarroll JA; Phillips PA, 2025, 'βIII-tubulin is a dual cell therapeutic target in pancreatic cancer and regulates sensitivity to TRAIL through a DR5-dependent mechanism', CANCER RESEARCH, 85, pp. A67 - A67, http://dx.doi.org/10.1158/1538-7445.PANCREATIC25-A067
    Journal articles | 2025
    Sharbeen G; Youkhana J; Netto KG; Raina AS; Chiang S; Haghighi KS; Kokkinos J; Pitiyarachchi O; Yang J; Wang T; Swarbrick A; Goldstein D; Phillips PA, 2025, 'Assessing the response of 3D human pancreatic tumor explants to standard chemotherapy', CANCER RESEARCH, 85, pp. B80 - B80, http://dx.doi.org/10.1158/1538-7445.PANCREATIC25-B080
    Journal articles | 2025
    Tang R; Tay SS; Sharbeen G; Herrmann D; Youkhana J; Timpson P; Phillips PA; Biro M, 2025, 'Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer-Associated Fibroblasts', European Journal of Immunology, 55, http://dx.doi.org/10.1002/eji.202451215
    Journal articles | 2024
    van der Woude H; Phan K; Kenwright DN; Goossens L; Hally KE; Currie MJ; Kokkinos J; Sharbeen G; Phillips PA; Henry CE, 2024, 'Development of a long term, ex vivo, patientderived explant model of endometrial cancer', Plos One, 19, http://dx.doi.org/10.1371/journal.pone.0301413
    Journal articles | 2023
    Chitty JL; Yam M; Perryman L; Parker AL; Skhinas JN; Setargew YFI; Mok ETY; Tran E; Grant RD; Latham SL; Pereira BA; Ritchie SC; Murphy KJ; Trpceski M; Findlay AD; Melenec P; Filipe EC; Nadalini A; Velayuthar S; Major G; Wyllie K; Papanicolaou M; Ratnaseelan S; Phillips PA; Sharbeen G; Youkhana J; Russo A; Blackwell A; Hastings JF; Lucas MC; Chambers CR; Reed DA; Stoehr J; Vennin C; Pidsley R; Zaratzian A; Da Silva AM; Tayao M; Charlton B; Herrmann D; Nobis M; Clark SJ; Biankin AV; Johns AL; Croucher DR; Nagrial A; Gill AJ; Grimmond SM; Chantrill LA; Chou A; Dwarte T; Metcalf XL; Jeong G; Kenyon L; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeo D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J, 2023, 'A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer', Nature Cancer, 4, pp. 1326 - 1344, http://dx.doi.org/10.1038/s43018-023-00614-y
    Journal articles | 2022
    Kokkinos J; Sharbeen G; Haghighi KS; Youkhana J; Raina A; Pitiyarachchi O; Truong Q; Wenholz D; Laczka O; Kumar N; Goldstein D; Phillips PA, 2022, 'Abstract C073: CRO-67 is a novel therapeutic for pancreatic cancer: Implications for tumor and stromal reprogramming', Cancer Research, 82, pp. C073 - C073, http://dx.doi.org/10.1158/1538-7445.panca22-c073
    Journal articles | 2022
    Kokkinos J; Sharbeen G; Youkhana J; Boyer C; Goldstein D; Haghighi KS; McCarroll JA; Phillips PA, 2022, 'Abstract B076: βIII-Tubulin is a brake on extrinsic cell-death in pancreatic cancer', Cancer Research, 82, pp. B076 - B076, http://dx.doi.org/10.1158/1538-7445.panca22-b076
    Journal articles | 2022
    Ma Z; Wong SW; Forgham H; Esser L; Lai M; Leiske MN; Kempe K; Sharbeen G; Youkhana J; Mansfeld F; Quinn JF; Phillips PA; Davis TP; Kavallaris M; McCarroll JA, 2022, 'Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth', Biomaterials, 285, http://dx.doi.org/10.1016/j.biomaterials.2022.121539
    Journal articles | 2021
    Cong VT; Tilley RD; Sharbeen G; Phillips PA; Gaus K; Gooding JJ, 2021, 'How to exploit different endocytosis pathways to allow selective delivery of anticancer drugs to cancer cells over healthy cells', Chemical Science, 12, pp. 15407 - 15417, http://dx.doi.org/10.1039/d1sc04656j
    Journal articles | 2021
    Cong VT; Wang W; Tilley RD; Sharbeen G; Phillips PA; Gaus K; Gooding JJ, 2021, 'Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?', Advanced Functional Materials, 31, http://dx.doi.org/10.1002/adfm.202007880
    Journal articles | 2021
    Kokkinos J; Ignacio RM; Haghighi K; Kopecky C; Sharbeen G; Gonzales-Aloy E; Youkhana J; Butler L; Goldstein D; McCarroll J; Phillips P, 2021, 'Patient-derived pancreatic tumours in a dish: implications for real-time precision medicine', HPB, 23, pp. S235 - S235, http://dx.doi.org/10.1016/j.hpb.2020.11.590
    Journal articles | 2021
    Kokkinos J; Jensen A; Sharbeen G; McCarroll JA; Goldstein D; Haghighi KS; Phillips PA, 2021, 'Does the microenvironment hold the hidden key for functional precision medicine in pancreatic cancer?', Cancers, 13, http://dx.doi.org/10.3390/cancers13102427
    Journal articles | 2021
    Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Timpson P; Pereira BA; Ritchie S; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2021, 'Ex vivo culture of intact human patient derived pancreatic tumour tissue', Scientific Reports, 11, pp. 1944, http://dx.doi.org/10.1038/s41598-021-81299-0
    Journal articles | 2021
    Liu D; Sharbeen G; Phillips P; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Scarpa A; Lawlor RT; Corbo V; Bassi C; Biankin AV; Jamieson NB; Chang DK; Dreyer SB; Ford CE, 2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, http://dx.doi.org/10.1186/s12885-021-08952-9
    Journal articles | 2021
    Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Cancer‐Associated Fibroblasts: Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells (Adv. Biology 6/2021)', Advanced Biology, 5, http://dx.doi.org/10.1002/adbi.202170064
    Journal articles | 2021
    Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells', Advanced Biology, 5, pp. e2000525, http://dx.doi.org/10.1002/adbi.202000525
    Journal articles | 2021
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2020
    Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, 240, http://dx.doi.org/10.1016/j.biomaterials.2019.119742
    Journal articles | 2020
    Tjandra KC; McCarthy N; Yang L; Laos AJ; Sharbeen G; Phillips PA; Forgham H; Sagnella SM; Whan RM; Kavallaris M; Thordarson P; McCarroll JA, 2020, 'Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery', Journal of Medicinal Chemistry, 63, pp. 2181 - 2193, http://dx.doi.org/10.1021/acs.jmedchem.9b00851
    Journal articles | 2017
    Sharbeen G; Youkhana J; Mawson A; McCarroll J; Nunez A; Biankin A; Johns A; Goldstein D; Phillips P, 2017, 'MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity', Oncotarget, 8, pp. 9216 - 9229, http://dx.doi.org/10.18632/oncotarget.13985
    Journal articles | 2017
    Thientosapol ES; Sharbeen G; Edwin Lau KK; Bosnjak D; Durack T; Stevanovski I; Weninger W; Jolly CJ, 2017, 'Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2', Nucleic Acids Research, 45, pp. 3146 - 3157, http://dx.doi.org/10.1093/nar/gkw1300
    Journal articles | 2016
    Akerman A; Vennin C; Sharbeen G; Warren SC; Timpson P; Phillips PA, 2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, 40, pp. 16 - 22
    Journal articles | 2016
    McCarroll JA; Teo J; Boyer C; Youkhana J; Sagnella S; Duong H; Sharbeen G; Goldstein D; Davis T; Kavallaris M; Phillips P; Liu J, 2016, 'A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo.', Biomacromolecules, 17, pp. 2337 - 2351, http://dx.doi.org/10.1021/acs.biomac.6b00185
    Journal articles | 2016
    Sharbeen G; McCarroll J; Liu J; Youkhana J; Limbri LF; Biankin AV; Johns A; Kavallaris M; Goldstein D; Phillips PA, 2016, 'Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids', Neoplasia United States, 18, pp. 753 - 764, http://dx.doi.org/10.1016/j.neo.2016.10.011
    Journal articles | 2016
    Sharbeen G; Youkhana J; McCarroll J; Akerman A; Goldstein D; Phillips P, 2016, 'MutY-Homolog modulates pancreatic cancer cell survival and chemoresistance', Pancreatology, 16, pp. S5 - S5, http://dx.doi.org/10.1016/j.pan.2016.05.024
    Journal articles | 2015
    McCarroll JA; Sharbeen G; Liu J; Youkhana J; Goldstein D; McCarthy N; Limbri LF; Dischl D; Ceyhan GO; Erkan M; Johns AL; Biankin AV; Kavallaris M; Phillips PA; Johns A, 2015, 'βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer', Oncotarget, 6, pp. 2235 - 2249, http://dx.doi.org/10.18632/oncotarget.2946
    Journal articles | 2015
    Sharbeen G; McCarroll J; Goldstein D; Phillips PA, 2015, 'Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer', Frontiers in Nutrition, 2, pp. 10, http://dx.doi.org/10.3389/fnut.2015.00010
    Journal articles | 2014
    McCarroll JA; Naim S; Sharbeen G; Russia N; Lee J; Kavallaris M; Goldstein D; Phillips PA, 2014, 'Role of pancreatic stellate cells in chemoresistance in pancreatic cancer', Frontiers in Physiology, 5 APR, pp. 141, http://dx.doi.org/10.3389/fphys.2014.00141
    Journal articles | 2013
    Teo J; Erlich RB; Sagnella S; Dwarte T; Davis TP; Kavallaris M; McCarroll J; Boyer C; Duong HTT; Phillips P; Sharbeen G; Goldstein D, 2013, 'Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers', Molecular Pharmaceutics, 10, pp. 2435 - 2444, http://dx.doi.org/10.1021/mp400049e
    Journal articles | 2012
    Sharbeen G; Yee CWY; Smith AL; Jolly CJ, 2012, 'Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase', Journal of Experimental Medicine, 209, pp. 965 - 974, http://dx.doi.org/10.1084/jem.20112379
    Journal articles | 2011
    Yao TW; Kim WS; Yu DMT; Sharbeen G; McCaughan GW; Choi KY; Xia P; Gorrell MD, 2011, 'A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling', Molecular Cancer Research, 9, pp. 948 - 959, http://dx.doi.org/10.1158/1541-7786.MCR-10-0272
    Journal articles | 2010
    Sharbeen G; Cook AJL; Lau KKE; Raftery J; Yee CWY; Jolly CJ, 2010, 'Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo', Nucleic Acids Research, 38, pp. 8120 - 8130, http://dx.doi.org/10.1093/nar/gkq682
    Journal articles | 2009
    Peters KM; Sharbeen G; Theis T; Skurray RA; Brown MH, 2009, 'Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription', Biochemistry, 48, pp. 9794 - 9800, http://dx.doi.org/10.1021/bi901102h
  • Conference Abstracts | 2024
    Pitiyarachchi O; Lin FP; Spooner A; Sharbeen G; Barker HP; Thornton K; Collignon E; Ballinger ML; Thomas DM; Magenau A; Porazinski S; Raina A; Sjoquist KM; Chantrill LA; Gebski V; Sowmya A; Timpson P; Pajic M; Goldstein D; Phillips PA, 2024, 'Impact of symptom and functional burden on survival in pancreatic ductal adenocarcinoma (PDAC)', in ANNALS OF ONCOLOGY, ELSEVIER, SPAIN, Barcelona, Vol. 35, pp. S925 - S925, presented at Annual Congress of the European-Society-for-Medical-Oncology (ESMO), SPAIN, Barcelona, 13 September 2024 - 17 September 2024, http://dx.doi.org/10.1016/j.annonc.2024.08.1576
    Conference Abstracts | 2023
    Netto KG; Chiang S; Kokkinos J; Haghighi KS; Raina A; Pitiyarachchi O; Youkhana J; Truong Q; Wenholz D; Li X; Laczka O; Kumar N; Wilkinson J; Goldstein D; Sharbeen G; Phillips PA, 2023, 'CRO67 has therapeutic potential against pancreatic tumor cells and cancer associated fibroblasts', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference - Pancreatic Cancer, MA, Boston, 27 September 2023 - 30 September 2023, http://dx.doi.org/10.1158/1538-7445.PANCA2023-B062
    Other | 2023
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2023, Data from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, http://dx.doi.org/10.1158/0008-5472.c.6512931
    Conference Papers | 2022
    Kokkinos J; Sharbeen G; Haghighi KS; Youkhana J; Raina A; Pitiyarachchi O; Truong Q; Wenholz D; Laczka O; Kumar N; Goldstein D; Phillips PA, 2022, 'CRO-67 is a novel therapeutic for pancreatic cancer: Implications for tumor and stromal reprogramming.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, pp. 161 - 161, presented at AACR Special Conference - Pancreatic Cancer, MA, Boston, 13 September 2022 - 16 September 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000899825600205&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2022
    Kokkinos J; Sharbeen G; Ignacio RM; Pandzic E; Youkhana J; Boyer C; Haghighi K; Gunawarman M; Goldstein D; Gebski V; Pajic M; Pitiyarachchi O; Davis M; Schulstad G; Arkell OSM; Kopecky C; Gonzales-Aloy E; Erkan M; Morton J; Kavallaris M; Gunning P; Hardeman E; Johns A; Gill A; Whan R; Mawson A; Australian Pancreatic Cancer Genome Initiative ; McCarroll J; Phillips P, 2022, βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer, http://dx.doi.org/10.1101/2022.09.29.510034
    Conference Papers | 2022
    Kokkinos J; Sharbeen G; Youkhana J; Boyer C; Goldstein D; Haghighi KS; McCarroll JA; Phillips PA, 2022, 'ßIII-Tubulin is a brake on extrinsic cell-death in pancreatic cancer.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, pp. 108 - 109, presented at AACR Special Conference - Pancreatic Cancer, MA, Boston, 13 September 2022 - 16 September 2022
    Preprints | 2020
    Kokkinos J; Sharbeen G; Haghighi K; Ignacio RM; Kopecky C; Gonzales-Aloy E; Youkhana J; Pandzic E; Boyer C; Davis T; Butler L; Goldstein D; McCarroll J; Phillips P, 2020, Bringing the pancreas patient back to the bench: Ex vivo culture of intact human patient derived pancreatic tumour tissue, http://dx.doi.org/10.1101/2020.07.30.223925
    Preprints | 2020
    Sharbeen G; McCarroll J; Akerman A; Kopecky C; Youkhana J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox T; Pereira B; Chitty J; Fey S; Najumudeen A; Campbell A; Sansom O; Ignacio RM; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill A; Gonzales-Aloy E; Kokkinos J; Gebski V; Turner N; Apte M; Davis T; Morton J; Haghighi K; Australian Pancreatic Cancer Genome Initiative ; Phillips P, 2020, Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition, http://dx.doi.org/10.1101/2020.07.12.199638
    Conference Abstracts | 2018
    Akerman A; Sharbeen G; Holst J; Youkhana J; McCarroll J; Goldstein D; Erkan M; Phillips P, 2018, 'Targeting a solute carrier to metabolically reprogram tumour-promoting stromal cells in pancreatic cancer', in Pancreatology, Elsevier BV, Vol. 18, pp. S156 - S156, http://dx.doi.org/10.1016/j.pan.2018.05.419
    Conference Abstracts | 2018
    Kokkinos J; Sharbeen G; McCarroll J; Boyer C; Akerman A; Youkhana J; Davis TP; Goldstein D; Phillips PA, 2018, 'beta III-Tubulin is a Brake for External Cell-Death Signaling and Regulates TRAIL Sensitivity in Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Miami Beach, Florida, Vol. 47, pp. 1401 - 1401, presented at 49th Annual Meeting of the American Pancreatic Association, Miami Beach, Florida, 31 October 2018 - 03 November 2018, http://dx.doi.org/10.1097/MPA.0000000000001177
    Conference Papers | 2018
    Kokkinos J; Sharbeen G; Mccarroll J; Akerman A; Youkhana J; Goldstein D; Phillips P, 2018, 'beta III-Tubulin is a brake for external cell-death signaling and chemosensitivity in pancreatic cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 19 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000530647800030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Sharbeen G; Akerman A; McCarroll J; Boyer C; Holst J; Youkhana J; Davis TP; Goldstein D; Erkan M; Phillips PA, 2018, 'Metabolically Reprograming Pancreatic Stellate Cells Using a Novel Nanomedicine for the Treatment of Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1422 - 1422, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Phillips P; Sharbeen G; Youkhana J; Mawson A; McCarroll J; Akerman A; Goldstein D, 2016, 'MutY-Homolog Modulates Pancreatic Cancer Cell Survival and Chemoresistance', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 45, pp. 1534 - 1534, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000386978400183&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Sharbeen G; Youkhana J; Mawson A; Mccarroll J; Goldstein D; Phillips P, 2016, 'MutY-homolog modulates pancreatic cancer cell survival and chemoresistance', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 31, pp. 60 - 60, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000384664700111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Boyer C; Teo J; Phillips P; Erlich RB; Sagnella S; Sharbeen G; Dwarte T; Duong HTT; Goldstein D; Davis TP; Kavallaris M; Mccarroll J, 2015, 'Erratum: Effective Delivery of siRNA into Cancer Cells and Tumors Using Well-Defined Biodegradable Cationic Star Polymers (Molecular Pharmaceutics (2013) 10: 6 (2435−2444) DOI: 10.1021/mp400049e)', in Molecular Pharmaceutics, Vol. 12, pp. 1004, http://dx.doi.org/10.1021/acs.molpharmaceut.5b00092
    Conference Abstracts | 2015
    Sharbeen G; Liu J; McCarroll J; Limbri L; Youkhana J; Goldstein D; Kavallaris M; Phillips P, 2015, 'beta IVb-Tubulin is a Novel Therapeutic Target for the Treatment of Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 44, pp. 1414 - 1414, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000363324000259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Sharbeen G; McCarroll J; Liu J; Youkhana J; Goldstein D; Kavallaris M; Phillips P, 2015, 'beta III-Tubulin Regulates Sensitivity to Nab-Paclitaxel (Abraxane (R)) in Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 44, pp. 1414 - 1415, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000363324000260&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Teo J; Boyer C; Sharbeen G; Sagnella S; Liu J; Youkhana J; Duong HT; Goldstein D; Davis TP; Kavallaris M; McCarroll J; Phillips PA, 2014, 'Design and Synthesis of Novel PEGylated Star Nanoparticles as Delivery Agents for Short-Interfering RNA (siRNA) to Pancreatic Cancer Cells', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, pp. 1416 - 1416, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344362600356&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Youkhana J; Mccarroll J; Sharbeen G; Erkan M; Liu J; Goldstein D; Phillips PA, 2014, 'Heat shock protein 47 is a potential therapeutic target for the depletion of cancer-promoting stromal cells in pancreatic cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 7 - 7, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Sharbeen G; Liu J; McCarroll J; Youkhana J; Teo J; McCarthy N; Goldstein D; Kavallaris M; Phillips PA, 2013, 'beta III-Tubulin is a Novel Therapeutic Target for the Treatment of Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, pp. 1381 - 1381, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330468400204&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Sharbeen G; Liu J; Mccarroll J; Youkhana J; Teo J; Mccarthy N; Goldstein D; Kavallaris M; Phillips PA, 2013, 'beta III-tubulin is a novel therapeutic target for the treatment of pancreatic cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 12 - 12, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324106900022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Teo J; Boyer C; Liu J; Sharbeen G; Erlich R; Youkhana J; Duong HT; Goldstein D; Davis TP; Kavallaris M; McCarroll J; Phillips PA, 2013, 'Inhibition of beta III-Tubulin Using a Novel Nanoparticle-siRNA Approach Sensitizes Pancreatic Cancer Cells to Chemotherapy', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, pp. 1385 - 1385, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330468400222&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Jolly C; Sharbeen G; Yee C; Smith A, 2012, 'Processing of AID-induced uracils in distinct cell cycle phases', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, MA, Boston, presented at 99th Annual Meeting of the American-Association-of-Immunologists, MA, Boston, 04 May 2012 - 08 May 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000304659700662&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1