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Dr Gregory Walker

Dr Gregory Walker

Research Associate

PhD (Virology), 2022, University of New South Wales

B Biomedical Science (Hons), 2015, University of Newcastle

Medicine & Health
School of Biomedical Sciences

I am an early career researcher and virologist based at the Virology Research Laboratory (Prince of Wales Hospital Randwick), University of New South Wales. My areas of expertise include 1) viral detection and diagnostics, 2) genomic surveillance of viral epidemics, and 3) characterization of antibody-mediated immunity to viral infections. I have experience in whole genome sequencing of respiratory viruses (RSV, Influenzavirus and SARS-CoV-2), serological techniques for viral detection and characterisation, and culturing of clinical virus isolates (including highly infectious variants of SARS-CoV-2 under PC3 conditions). I am also an Associate Investigator within the Virology theme of the Environmental Determinants of Islet Autoimmunity (ENDIA) Study, following 1,500 mother-infant pairs with a first-degree relative with type 1 diabetes across Australia (https://endia.org.au).
E-mail
gregory.walker@unsw.edu.au
Location
Prince of Wales Hospital, Randwick
  • Journal articles | 2024
    Horsburgh BA; Walker GJ; Kelleher A; Lloyd AR; Bull RA; Giallonardo FD, 2024, 'Next-Generation Sequencing Methods for Near-Real-Time Molecular Epidemiology of HIV and HCV', Reviews in Medical Virology, 34, http://dx.doi.org/10.1002/rmv.70001
    Journal articles | 2024
    Rodrigo C; Walker G; Sevendal ATK; Nguyen C; Stelzer-Braid S; Rawlinson W; Graves S; Gidding HF; Stenos J; Lloyd AR, 2024, 'Acute Q fever in patients with an influenza-like illness in regional New South Wales, Australia', PLoS Neglected Tropical Diseases, 18, http://dx.doi.org/10.1371/journal.pntd.0012385
    Journal articles | 2024
    Sevendal ATK; Hurley S; Bartlett AW; Rawlinson W; Walker GJ, 2024, 'Systematic Review of the Efficacy and Safety of RSV-Specific Monoclonal Antibodies and Antivirals in Development', Reviews in Medical Virology, 34, http://dx.doi.org/10.1002/rmv.2576
    Journal articles | 2024
    Walker G; Rawlinson W, 2024, 'Contextualising COVID-19 in 2024', Microbiology Australia, 45, pp. 3, http://dx.doi.org/10.1071/MA24002
    Journal articles | 2024
    Walker GJ; Foster CSP; Sevendal A; Domazetovska A; Kamalakkannan A; Williams PCM; Kim KW; Condylios A; Stelzer-Braid S; Bartlett AW; Rawlinson W, 2024, 'Clinical, Genomic, and Immunological Characterization of RSV Surge in Sydney, Australia, 2022', Pediatrics, 153, http://dx.doi.org/10.1542/peds.2023-063667
    Journal articles | 2024
    Wang X; Kim KW; Walker G; Stelzer-Braid S; Scotch M; Rawlinson WD, 2024, 'Genome characterization of influenza A and B viruses in New South Wales, Australia, in 2019: A retrospective study using high-throughput whole genome sequencing', Influenza and other Respiratory Viruses, 18, http://dx.doi.org/10.1111/irv.13252
    Journal articles | 2024
    Wang X; Walker G; Kim KW; Stelzer-Braid S; Scotch M; Rawlinson WD, 2024, 'The resurgence of influenza A/H3N2 virus in Australia after the relaxation of COVID-19 restrictions during the 2022 season', Journal of Medical Virology, 96, http://dx.doi.org/10.1002/jmv.29922
    Journal articles | 2023
    Akerman A; Milogiannakis V; Jean T; Esneau C; Silva MR; Ison T; Fichter C; Lopez JA; Chandra D; Naing Z; Caguicla J; Li D; Walker G; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Foster CSP; Sato K; Lee S; Song Y; Mao L; Sigmund A; Phu A; Vande More AM; Hunt S; Douglas M; Caterson I; Britton W; Sandgren K; Bull R; Lloyd A; Triccas J; Tangye S; Bartlett NW; Darley D; Matthews G; Stark DJ; Petoumenos K; Rawlinson WD; Murrell B; Brilot F; Cunningham AL; Kelleher AD; Aggarwal A; Turville SG, 2023, 'Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level', eBioMedicine, 90, http://dx.doi.org/10.1016/j.ebiom.2023.104545
    Journal articles | 2023
    Bennett D; Chen X; Walker GJ; Mehdipour M; Stelzer-Braid S; Rawlinson WD; Hibbert DB; Tilley RD; Gooding JJ, 2023, 'Erratum: Machine Learning Color Feature Analysis of a High Throughput Nanoparticle Conjugate Sensing Assay (Analytical Chemistry (2023) 95:6 (550-6558) DOI: 10.1021/acs.analchem.2c05292)', Analytical Chemistry, 95, pp. 8393, http://dx.doi.org/10.1021/acs.analchem.3c01892
    Journal articles | 2023
    Bennett D; Chen X; Walker GJ; Stelzer-Braid S; Rawlinson WD; Hibbert DB; Tilley RD; Gooding JJ; Hibbert B, 2023, 'Machine Learning Color Feature Analysis of a High Throughput Nanoparticle Conjugate Sensing Assay', Analytical Chemistry, 95, pp. 6550 - 6558, http://dx.doi.org/10.1021/acs.analchem.2c05292
    Journal articles | 2023
    Bowden-Reid E; Ledger S; Zhang Y; Di Giallonardo F; Aggarwal A; Stella AO; Akerman A; Milogiannakis V; Walker G; Rawlinson W; Turville S; Kelleher AD; Ahlenstiel C, 2023, 'Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2', Antiviral Research, 217, http://dx.doi.org/10.1016/j.antiviral.2023.105677
    Journal articles | 2023
    Foster CSP; Bull RA; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker GJ; Shrestha LB; Van Hal SJ; Kim KW; Rawlinson WD, 2023, 'Persistence of a Frameshifting Deletion in SARS-CoV-2 ORF7a for the Duration of a Major Outbreak', Viruses, 15, http://dx.doi.org/10.3390/v15020522
    Journal articles | 2023
    Rouet R; Henry JY; Johansen MD; Sobti M; Balachandran H; Langley DB; Walker GJ; Lenthall H; Jackson J; Ubiparipovic S; Mazigi O; Schofield P; Burnett DL; Brown SHJ; Martinello M; Hudson B; Gilroy N; Post JJ; Kelleher A; Jäck HM; Goodnow CC; Turville SG; Rawlinson WD; Bull RA; Stewart AG; Hansbro PM; Christ D, 2023, 'Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-36295-5
    Journal articles | 2022
    Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Stella AO; Kindinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Jean T; Foster CSP; Christ D; Hoppe AC; Munier ML; Darley D; Churchill M; Stark DJ; Matthews G; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern', eBioMedicine, 84, http://dx.doi.org/10.1016/j.ebiom.2022.104270
    Journal articles | 2022
    Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7
    Journal articles | 2022
    Hodgkins C; Buckton LK; Walker GJ; Crossett B; Cordwell SJ; Horvath AR; Rawlinson WD, 2022, 'Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-16250-y
    Journal articles | 2022
    Homaira N; Binks M; Walker G; Larter N; Clark K; Campbell M; McHugh L; Briggs N; Nyiro J; Stelzer-Braid S; Hu N; Macartney K; Snelling T; Omer SB; Rawlinson W; Andrews R; Jaffe A, 2022, 'Transplacental transfer of RSV antibody in Australian First Nations infants', Journal of Medical Virology, 94, pp. 782 - 786, http://dx.doi.org/10.1002/jmv.27383
    Journal articles | 2022
    Kim KW; Wang X; Adhikari A; Yeang M; Jenkins F; Naing Z; Walker GJ; Foster CSP; Stelzer-Braid S; Deveson I; Craig ME; Tedla N; Bull RA; Martinello M; Pinto AN; Chan R; Turville S; Rawlinson WD; van Hal S, 2022, 'Persistent high-level shedding of cultivable SARS-CoV-2 Delta virus 33 days after onset of COVID-19 in a hospitalized patient with pneumonia', Journal of Medical Virology, 94, pp. 4043 - 4046, http://dx.doi.org/10.1002/jmv.27832
    Journal articles | 2022
    Walker GJ; Stelzer-Braid S; Shorter C; Honeywill C; Wynn M; Willenborg C; Barnes P; Kang J; Pierse N; Crane J; Howden-Chapman P; Rawlinson WD, 2022, 'Viruses associated with acute respiratory infection in a community-based cohort of healthy New Zealand children', Journal of Medical Virology, 94, pp. 454 - 460, http://dx.doi.org/10.1002/jmv.25493
    Journal articles | 2021
    Burnett DL; Jackson KJL; Langley DB; Aggrawal A; Stella AO; Johansen MD; Balachandran H; Lenthall H; Rouet R; Walker G; Saunders BM; Singh M; Li H; Henry JY; Jackson J; Stewart AG; Witthauer F; Spence MA; Hansbro NG; Jackson C; Schofield P; Milthorpe C; Martinello M; Schulz SR; Roth E; Kelleher A; Emery S; Britton WJ; Rawlinson WD; Karl R; Schäfer S; Winkler TH; Brink R; Bull RA; Hansbro PM; Jäck HM; Turville S; Christ D; Goodnow CC, 2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, 54, pp. 2908 - 2921.e6, http://dx.doi.org/10.1016/j.immuni.2021.10.019
    Journal articles | 2021
    Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, 13, http://dx.doi.org/10.1080/19420862.2021.1922134
    Journal articles | 2021
    Tea F; Stella AO; Aggarwal A; Darley DR; Pilli D; Vitale D; Merheb V; Lee FXZ; Cunningham P; Walker GJ; Fichter C; Brown DA; Rawlinson WD; Isaacs SR; Mathivanan V; Hoffmann M; Pöhlman S; Mazigi O; Christ D; Rockett RJ; Sintchenko V; Hoad VC; Irving DO; Dore GJ; Gosbell IB; Kelleher AD; Matthews GV; Brilot F; Turville SG, 2021, 'SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants', PLoS Medicine, 18, http://dx.doi.org/10.1371/journal.pmed.1003656
    Journal articles | 2021
    Walker GJ; Davis R; Naing Z; McEntee B; Lu Y; Denadija T; Rawlinson WD, 2021, 'Serological Detection of SARS-CoV-2 IgG Using Commercially Available Enzyme Immunoassays on Dried Blood Spots Collected from Patients', Microbiology Spectrum, 9, http://dx.doi.org/10.1128/Spectrum.01245-21
    Journal articles | 2021
    Walker GJ; Naing Z; Stella AO; Yeang M; Caguicla J; Ramachandran V; Isaacs SR; Agapiou D; Bull RA; Stelzer-Braid S; Daly J; Gosbell IB; Hoad VC; Irving DO; Pink JM; Turville S; Kelleher AD; Rawlinson WD, 2021, 'Sars coronavirus-2 microneutralisation and commercial serological assays correlated closely for some but not all enzyme immunoassays', Viruses, 13, http://dx.doi.org/10.3390/v13020247
    Journal articles | 2020
    Kok CC; Ramachandran V; Egilmezer E; Ray S; Walker GJ; Rawlinson WD, 2020, 'Serological testing for infectious diseases markers of donor specimens from 24 h after death show no significant change in outcomes from other specimens', Cell and Tissue Banking, 21, pp. 171 - 179, http://dx.doi.org/10.1007/s10561-020-09810-x
    Journal articles | 2020
    Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791
    Journal articles | 2020
    Stelzer-Braid S; Walker GJ; Aggarwal A; Isaacs SR; Yeang M; Naing Z; Ospina Stella A; Turville SG; Rawlinson WD, 2020, 'Virus isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for diagnostic and research purposes', Pathology, 52, pp. 760 - 763, http://dx.doi.org/10.1016/j.pathol.2020.09.012
    Journal articles | 2020
    Tea F; Stella AO; Aggarwal A; Darley DR; Pilli D; Vitale D; Merheb V; Lee FXZ; Cunningham P; Walker GJ; Brown DA; Rawlinson WD; Isaacs SR; Mathivanan V; Hoffman M; Pöhlmann S; Dwyer DE; Rockett R; Sintchenko V; Hoad VC; Irving DO; Dore GJ; Gosbell IB; Kelleher AD; Matthews GV; Brilot F; Turville SG, 2020, 'SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants', , http://dx.doi.org/10.1101/2020.12.19.20248567
    Journal articles | 2020
    Van Bockel D; Munier CML; Turville S; Badman SG; Walker G; Stella AO; Aggarwal A; Yeang M; Condylios A; Kelleher AD; Applegate TL; Vallely A; Whiley D; Rawlinson W; Cunningham P; Kaldor J; Guy R, 2020, 'Evaluation of commercially available viral transport medium (VTM) for SARS-CoV-2 inactivation and use in point-of-care (POC) testing', Viruses, 12, pp. 1208, http://dx.doi.org/10.3390/v12111208
    Journal articles | 2020
    Walker G; Clifford V; Bansal N; Stella AO; Turville S; Stelzer-Braid S; Klein L; Rawlinson W, 2020, 'SARS-CoV-2 in human milk is inactivated by Holder pasteurization but not cold storage', , http://dx.doi.org/10.1101/2020.06.18.20134395
    Journal articles | 2020
    Walker G; Naing Z; Stella AO; Yeang M; Caguicla J; Ramachandran V; Isaacs S; Agapiou D; Bull R; Stelzer-Braid S; Daly J; Gosbell I; Hoad V; Irving D; Pink J; Turville S; Kelleher A; Rawlinson W, 2020, 'SARS Coronavirus-2 microneutralisation and commercial serological assays correlated closely for some but not all enzyme immunoassays', , http://dx.doi.org/10.1101/2020.12.07.20245696
    Journal articles | 2020
    Walker GJ; Clifford V; Bansal N; Stella AO; Turville S; Stelzer-Braid S; Klein LD; Rawlinson W, 2020, 'SARS-CoV-2 in human milk is inactivated by Holder pasteurisation but not cold storage', Journal of Paediatrics and Child Health, 56, pp. 1872 - 1874, http://dx.doi.org/10.1111/jpc.15065
    Journal articles | 2018
    Egilmezer E; Walker GJ; Bakthavathsalam P; Peterson JR; Gooding JJ; Rawlinson W; Stelzer-Braid S, 2018, 'Systematic review of the impact of point-of-care testing for influenza on the outcomes of patients with acute respiratory tract infection', Reviews in Medical Virology, 28, pp. e1995, http://dx.doi.org/10.1002/rmv.1995
    Journal articles | 2018
    Theis T; Lau KA; Gray JL; Oxenford CJ; Walker GJ; Rawlinson WD, 2018, 'Proficiency testing for the detection of Middle East respiratory syndrome coronavirus demonstrates global capacity to detect Middle East respiratory syndrome coronavirus', Journal of Medical Virology, 90, pp. 1827 - 1833, http://dx.doi.org/10.1002/jmv.25266
  • Preprints | 2023
    Aggarwal A; Fichter C; Milogiannakis V; Ison T; Ruiz Silva M; Esneau C; Bartlett N; Burrell L; Patel S; Churchill M; Angelovich T; Walker G; Rawlinson W; Yeang M; Kok J; Sintchenkov V; Chandra D; Kindinger A; Akerman A; Parry R; Sng J; Neely G; Moreno C; Loo L; Kelleher A; Brilot F; Khromykh A; Turville S, 2023, TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2, http://dx.doi.org/10.1101/2023.09.22.558930
    Preprints | 2023
    Foster CSP; Walker G; Jean T; Wong M; Brassil L; Isaacs S; Lyu Y; Turville S; Kelleher A; Rawlinson W, 2023, Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution, http://dx.doi.org/10.1101/2023.11.02.565396
    Preprints | 2022
    Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Kidinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Coppola G; Yeang M; Jean T; Foster C; Hoppe AC; Ling Munier M; Darley D; Churchill M; Starck D; Christ D; Matthews G; Rawlinson W; Kelleher A; Turville S, 2022, SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, http://dx.doi.org/10.1101/2022.07.07.22277128
    Preprints | 2022
    Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Kidinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Yeang M; Jean T; Foster C; Hoppe AC; Munier ML; Darley D; Churchill M; Starck D; Christ D; Matthews G; Rawlinson W; Kelleher A; Turville S, 2022, SARS-CoV-2 Omicron BA.5: Evolving Tropism and Evasion of Potent Humoral Responses and Resistance to Clinical Immunotherapeutics Relative to Viral Variants of Concern, http://dx.doi.org/10.2139/ssrn.4157473
    Preprints | 2022
    Aggarwal A; Stella A; Akerman A; Walker G; Milogiannakis V; McAllery S; Esneau C; Silva MR; Lu Y; Forster C; Hal SV; Mathivanan V; Fitcher C; Hoppe AC; Munier ML; Darley D; Matthews G; Starck D; Robosa R; Bartlett N; Rawlinson W; Kelleher A; Turville S, 2022, Rapid isolation and resolution immune evasion and viral fitness across contemporary SARS-CoV-2 variants, http://dx.doi.org/10.21203/rs.3.rs-1210846/v1
    Preprints | 2022
    Akerman A; Milogiannakis V; Jean T; Esneau C; Silva MR; Ison T; Fitcher C; Lopez J; Chandra D; Naing Z; Caguicla J; Li D; Walker G; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Foster CSP; Sato K; Lee S; Song Y; Mao L; Sigmund A; Phu A; Vande More AM; Hunt S; Douglas M; Caterson I; Sandgren K; Bull R; Lloyd A; Triccas J; Tangye S; Bartlett N; Darley D; Matthews G; Stark D; Rawlinson W; Murrell B; Brilot F; Cunningham A; Kelleher A; Aggarwal A; Turville S, 2022, Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sublineages in the face of maturing antibody breadth at the population level, http://dx.doi.org/10.1101/2022.12.06.22283000
    Preprints | 2022
    Foster CSP; Bull R; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker G; Shrestha LB; van Hal S; Kim KW; Rawlinson W, 2022, Persistence of a SARS-CoV-2 variant with a frameshifting deletion for the duration of a major outbreak, http://dx.doi.org/10.1101/2022.09.06.22279658
    Preprints | 2022
    Rouet R; Henry J; Johansen M; Sobti M; Balachandran H; Langley D; Walker G; Lenthall H; Jackson J; Ubiparipovic S; Mazigi O; Schofield P; Burnett D; Brown S; Martinello M; Hudson B; Gilroy N; Post J; Kelleher A; Jäck H-M; Goodnow C; Turville S; Rawlinson W; Bull R; Stewart A; Hansbro P; Christ D, 2022, Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients, http://dx.doi.org/10.1101/2022.10.19.512954
    Preprints | 2021
    Walker GJ; Davis R; Naing Z; McEntee B; Lu Y; Denadija T; Rawlinson WD, 2021, Serological detection of SARS-CoV-2 IgG using commercially available immunoassays on dried blood spots collected from patients, http://dx.doi.org/10.1101/2021.08.11.21261877

NHMRC Investigator (EL1), 2024-2028. CIA, $662,040.

Characterising viruses that promote the development of type 1 diabetes. NHMRC European Partnership, 2024-2027. CID (CIA-Kim), $499,999

Epidemiology of Respiratory Syncytial Virus and other respiratory viruses. GSK Supported Study, 2023-2025. CIA, $95,654

Viral genetic determinants of respiratory syncytial virus (RSV) underlying clinical disease severity in pediatric infection. Thrasher Research Fund, 2023. CIA, US$25,000.

 

My Research Supervision

1x PhD student (School of Biomedical Sciences), 2022-2024, Genomic characterisation of influenza viruses

1x Honours student (School of Biomedical Sciences), 2024, Wastewater surveillance of respiratory viruses

 

2025: 1x Honours student committed