Dr Hansen Kosasih

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I am a Senior Research Officer at the Children's Cancer Institute specialising in cancer genomics, precision medicine, and functional genomics of paediatric leukemia. My research focuses on understanding and targeting oncogenic drivers in high-risk acute lymphoblastic leukemia (ALL). Leveraging a unique combination of bioinformatics, molecular biology, epigenetics, and CRISPR tools, my goal is to uncover therapeutic vulnerabilities and improve outcomes for children with leukaemia.

E-mail

hkosasih@ccia.org.au

Journal articles | 2024

Beck D; Cao H; Tian F; Huang Y; Jiang M; Zhao H; Tai X; Xu W; Kosasih HJ; Kealy DJ; Zhao W; Taylor SJ; Couttas TA; Song G; Chacon-Fajardo D; Walia Y; Wang M; Dowle AA; Holding AN; Bridge KS; Zhang C; Wang J; Mi JQ; Lock RB; de Bock CE; Jing D, 2024, 'PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia', Nature communications, 15, pp. 9697, http://dx.doi.org/10.1038/s41467-024-54096-2

Journal articles | 2024

Kosasih HJ; Healey G; Brennan MS; Bjelosevic S; Sadras T; Jalud FB; Ibnat T; Ng AP; Mayoh C; Mao J; Tax G; Ludlow LEA; Johnstone RW; Herold MJ; Khaw SL; de Bock CE; Ekert PG, 2024, 'A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax', HemaSphere, 8, pp. e1, http://dx.doi.org/10.1002/hem3.1

Journal articles | 2024

Kosasih HJ; de Bock CE, 2024, 'Less is more: Depleting myeloid-biased HSCs to restore immune function', HemaSphere, 8, pp. e125, http://dx.doi.org/10.1002/hem3.125

Journal articles | 2024

Randall J; Evans K; Watts B; Kosasih HJ; Smith CM; Earley EJ; Erickson SW; Jocoy EL; Bult CJ; Teicher BA; de Bock CE; Smith MA; Lock RB, 2024, 'In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts', Experimental Hematology, 132, pp. 104176, http://dx.doi.org/10.1016/j.exphem.2024.104176

Journal articles | 2024

Toscan CE; McCalmont H; Ashoorzadeh A; Lin X; Fu Z; Doculara L; Kosasih HJ; Cadiz R; Zhou A; Williams S; Evans K; Khalili F; Cai R; Yeats KL; Gifford AJ; Pickford R; Mayoh C; Xie J; Henderson MJ; Trahair TN; Patterson AV; Smaill JB; de Bock CE; Lock RB, 2024, 'The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia', Blood Cancer Journal, 14, pp. 192, http://dx.doi.org/10.1038/s41408-024-01180-x

Journal articles | 2023

De Coninck S; De Smedt R; Lintermans B; Reunes L; Kosasih HJ; Reekmans A; Brown LM; Van Roy N; Palhais B; Roels J; Van der Linden M; Van Dorpe J; Ntziachristos P; Van Delft FW; Mansour MR; Pieters T; Lammens T; De Moerloose B; De Bock CE; Goossens S; Van Vlierberghe P, 2023, 'Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma.', Haematologica, 109, http://dx.doi.org/10.3324/haematol.2023.283981

Journal articles | 2023

Gu A; Schmidt B; Lonsdale A; Jalaldeen R; Kosasih HJ; Brown LM; Sadras T; Ekert PG; Oshlack A, 2023, 'TALLSorts: a T-cell acute lymphoblastic leukemia subtype classifier using RNA-seq expression data', Blood Advances, 7, pp. 7402 - 7406, http://dx.doi.org/10.1182/bloodadvances.2023010385

Journal articles | 2023

Lonsdale A; Halman A; Brown L; Kosasih H; Ekert P; Oshlack A, 2023, 'Toblerone: detecting exon deletion events in cancer using RNA-seq', F1000Research, 12, http://dx.doi.org/10.12688/f1000research.129490.1

Journal articles | 2023

Omari SA; Kosasih HJ; Chung T; de Bock CE, 2023, 'In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia', Heliyon, 9, http://dx.doi.org/10.1016/j.heliyon.2023.e22085

Journal articles | 2023

Ryland GL; Umeda M; Holmfeldt L; Lehmann S; Herlin MK; Ma J; Khanlari M; Rubnitz JE; Ries RE; Kosasih HJ; Ekert PG; Goh HN; Tiong IS; Grimmond SM; Haferlach C; Day RB; Ley TJ; Meshinchi S; Ma X; Blombery P; Klco JM, 2023, 'Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions', Blood, 141, pp. 800 - 805, http://dx.doi.org/10.1182/blood.2022017874

Journal articles | 2023

Sadras T; Jalud FB; Kosasih HJ; Horne CR; Brown LM; El-Kamand S; de Bock CE; McAloney L; Ng AP; Davidson NM; Ludlow LEA; Oshlack A; Cowley MJ; Khaw SL; Murphy JM; Ekert PG, 2023, 'Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL', Leukemia, 37, pp. 1 - 5, http://dx.doi.org/10.1038/s41375-023-01843-x

Journal articles | 2022

Brown LM; Hediyeh-Zadeh S; Sadras T; Huckstep H; Sandow JJ; Bartolo RC; Kosasih HJ; Davidson NM; Schmidt B; Bjelosevic S; Johnstone R; Webb AI; Khaw SL; Oshlack A; Davis MJ; Ekert PG, 2022, 'SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 2373 - 2387, http://dx.doi.org/10.1182/bloodadvances.2021006076

Journal articles | 2022

Schmidt B; Brown LM; Ryland GL; Lonsdale A; Kosasih HJ; Ludlow LE; Majewski IJ; Blombery P; Ekert PG; Davidson NM; Oshlack A, 2022, 'ALLSorts: an RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 4093 - 4097, http://dx.doi.org/10.1182/bloodadvances.2021005894

Journal articles | 2021

Schmidt B; Brown L; Ryland G; Lonsdale A; Kosasih H; Ludlow L; Majewski I; Blombery P; Ekert P; Davidson N; Oshlack A, 2021, 'ALLSorts: a RNA-Seq classifier for B-Cell Acute Lymphoblastic Leukemia', , http://dx.doi.org/10.1101/2021.08.01.454393

Journal articles | 2020

Kosasih HJ; Davidson NM; Bjelosevic S; Morrish E; Brennan MS; Oshlack A; Johnstone RW; Brumatti G; Khaw SL; Ekert PG, 2020, 'MLL-TFE3: A novel and aggressive KMT2A fusion identified in infant leukemia', Blood Advances, 4, pp. 4918 - 4923, http://dx.doi.org/10.1182/BLOODADVANCES.2020002708

Journal articles | 2019

Meyer C; Lopes BA; Caye-Eude A; Cavé H; Arfeuille C; Cuccuini W; Sutton R; Venn NC; Oh SH; Tsaur G; Escherich G; Feuchtinger T; Kosasih HJ; Khaw SL; Ekert PG; Pombo-de-Oliveira MS; Bidet A; Djahanschiri B; Ebersberger I; Zaliova M; Zuna J; Zermanova Z; Juvonen V; Grümayer RP; Fazio G; Cazzaniga G; Larghero P; Emerenciano M; Marschalek R, 2019, 'Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions', Leukemia, 33, pp. 2306 - 2340, http://dx.doi.org/10.1038/s41375-019-0451-7

Journal articles | 2017

Narayan N; Morenos L; Phipson B; Willis SN; Brumatti G; Eggers S; Lalaoui N; Brown LM; Kosasih HJ; Bartolo RC; Zhou L; Catchpoole D; Saffery R; Oshlack A; Goodall GJ; Ekert PG, 2017, 'Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia', Leukemia, 31, pp. 808 - 820, http://dx.doi.org/10.1038/leu.2016.279

Journal articles | 2016

Kosasih HJ; Last K; Rogerson FM; Golub SB; Gauci SJ; Russo VC; Stanton H; Wilson R; Lamande SR; Holden P; Fosang AJ, 2016, 'A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers', Journal of Biological Chemistry, 291, pp. 3197 - 3208, http://dx.doi.org/10.1074/jbc.M115.704817
Preprints | 2024

Jing D; Beck D; Cao H; Tian F; Huang Y; Zhao H; Tai X; XU WENQIAN; Kosasih H; Kealy D; Bridge K; Zhao W; Holding A; Dowle A; Taylor S; Song G; Fajardo D; Walia Y; Wang M; Zhang C; Wang J; Mi J-Q; Lock R; de Bock C, 2024, PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.21203/rs.3.rs-3872306/v1

Conference Abstracts | 2023

Lock RB; Toscan CE; McCalmont H; Evans K; Doculara L; Kosasih HJ; Gifford AJ; Ashoorzadeh A; Lin X; Trahair TN; De Bock CE; Patterson AV; Smaill JB, 2023, 'The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 142, pp. 4251 - 4251, http://dx.doi.org/10.1182/blood-2023-181298

Preprints | 2022

Lonsdale A; Halman A; Brown L; Kosasih H; Ekert P; Oshlack A, 2022, Toblerone: detecting exon deletion events in cancer using RNA-seq, http://dx.doi.org/10.1101/2022.10.27.514132

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