Dr Hartmut   Cuny
Conjoint Lecturer

Dr Hartmut Cuny

medicine-health
St Vincent's Clinical School

Dr Cuny is a Senior Postdoctoral Scientist at the Victor Chang Cardiac Research Institute, and a Conjoint Lecturer with the St Vincent's Clinical School.

Phone
+61-2-9295 8630
Location
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst NSW 2010

Publications

  • Journal articles | 2020
    Dr Hartmut Cuny
    Szot JO; Campagnolo C; Cao Y; Iyer KR; Cuny H; Drysdale T; Flores-Daboub JA; Bi W; Westerfield L; Liu P; Leung TN; Choy KW; Chapman G; Xiao R; Siu VM; Dunwoodie SL, 2020, 'Bi-allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders', American Journal of Human Genetics, vol. 106, pp. 129 - 136, http://dx.doi.org/10.1016/j.ajhg.2019.12.006
    Journal articles | 2020
    Dr Hartmut Cuny
    Cuny H; Rapadas M; Gereis J; Martin EMMA; Kirk RB; Shi H; Dunwoodie SL, 2020, 'NAD deficiency due to environmental factors or gene–environment interactions causes congenital malformations and miscarriage in mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 3738 - 3747, http://dx.doi.org/10.1073/pnas.1916588117
    Journal articles | 2019
    Dr Hartmut Cuny
    Alankarage D; Ip E; Szot JO; Munro J; Blue GM; Harrison K; Cuny H; Enriquez A; Troup M; Humphreys DT; Wilson M; Harvey RP; Sholler GF; Graham RM; Ho JWK; Kirk EP; Pachter N; Chapman G; Winlaw DS; Giannoulatou E; Dunwoodie SL, 2019, 'Identification of clinically actionable variants from genome sequencing of families with congenital heart disease', Genetics in Medicine, vol. 21, pp. 1111 - 1120, http://dx.doi.org/10.1038/s41436-018-0296-x
    Journal articles | 2018
    Dr Hartmut Cuny
    Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation. Genomic and precision medicine, vol. 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978
    Journal articles | 2018
    Dr Hartmut Cuny
    Cuny H; Yu R; Tae HS; Kompella SN; Adams DJ, 2018, 'α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition', British Journal of Pharmacology, vol. 175, pp. 1855 - 1868, http://dx.doi.org/10.1111/bph.13852
    Journal articles | 2016
    Dr Hartmut Cuny
    Cuny H; Kompella SN; Tae HS; Yu R; Adams DJ, 2016, 'Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins', Journal of Biological Chemistry, vol. 291, pp. 23779 - 23792, http://dx.doi.org/10.1074/jbc.M116.730804
    Journal articles | 2015
    Dr Hartmut Cuny
    Huynh TG; Cuny H; Slesinger PA; Adams DJ, 2015, 'Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor', Molecular Pharmacology, vol. 87, pp. 240 - 250, http://dx.doi.org/10.1124/mol.114.096156
    Journal articles | 2015
    Dr Hartmut Cuny
    Kompella SN; Cuny H; Hung A; Adams DJ, 2015, 'Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors', Molecular Pharmacology, vol. 88, pp. 993 - 1001, http://dx.doi.org/10.1124/mol.115.100503
    Journal articles | 2014
    Dr Hartmut Cuny
    Berecki G; McArthur JR; Cuny H; Clark RJ; Adams DJ, 2014, 'Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation', Journal of General Physiology, vol. 143, pp. 465 - 479, http://dx.doi.org/10.1085/jgp.201311104
    Journal articles | 2014
    Dr Hartmut Cuny
    Grimm C; Holdt LM; Chen CC; Hassan S; Müller C; Jörs S; Cuny H; Kissing S; Schröder B; Butz E; Northoff B; Castonguay J; Luber CA; Moser M; Spahn S; Lüllmann-Rauch R; Fendel C; Klugbauer N; Griesbeck O; Haas A; Mann M; Bracher F; Teupser D; Saftig P; Biel M; Wahl-Schott C, 2014, 'High susceptibility to fatty liver disease in two-pore channel 2-deficient mice', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms5699
    Journal articles | 2014
    Dr Hartmut Cuny
    Berecki G; McArthur JR; Cuny H; Clark RJ; Adams DJ, 2014, 'Differential CaV2.1 and CaV2.3 Channel Inhibition by Baclofen and α-Conotoxin Vc1.1 via GABAB Receptor Activation', Biophysical Journal, vol. 106, pp. 330a - 330a, http://dx.doi.org/10.1016/j.bpj.2013.11.1896
    Journal articles | 2013
    Dr Hartmut Cuny
    Inserra MC; Kompella SN; Vetter I; Brust A; Daly NL; Cuny H; Craik DJ; Alewood PF; Adams DJ; Lewis RJ, 2013, 'Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors', Biochemical Pharmacology, vol. 86, pp. 791 - 799, http://dx.doi.org/10.1016/j.bcp.2013.07.016
    Journal articles | 2013
    Dr Hartmut Cuny
    Yasuda T; Cuny H; Adams DJ, 2013, 'Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation', Journal of Physiology, vol. 591, pp. 2579 - 2591, http://dx.doi.org/10.1113/jphysiol.2012.249151
    Journal articles | 2013
    Dr Hartmut Cuny
    Grishin AA; Cuny H; Hung A; Clark RJ; Brust A; Akondi K; Alewood PF; Craik DJ; Adams DJ, 2013, 'Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors', Journal of Biological Chemistry, vol. 288, pp. 34428 - 34442, http://dx.doi.org/10.1074/jbc.M113.512582
    Journal articles | 2013
    Dr Hartmut Cuny
    Adams DJ; Harper AA; Grishin AA; Cuny H, 2013, 'Actions of α-conotoxins on neuronal nicotinic acetylcholine receptors and synaptic transmission in rat parasympathetic ganglia', Autonomic Neuroscience, vol. 177, pp. 306 - 306, http://dx.doi.org/10.1016/j.autneu.2013.08.027
    Journal articles | 2012
    Dr Hartmut Cuny
    Cuny H; De Faoite A; Huynh TG; Yasuda T; Berecki G; Adams DJ, 2012, 'γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins', Journal of Biological Chemistry, vol. 287, pp. 23948 - 23957, http://dx.doi.org/10.1074/jbc.M112.342998
    Journal articles | 2009
    Dr Hartmut Cuny
    Zong X; Schieder M; Cuny H; Fenske S; Gruner C; Rötzer K; Griesbeck O; Harz H; Biel M; Wahl-Schott C, 2009, 'The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores', Pflugers Archiv European Journal of Physiology, vol. 458, pp. 891 - 899, http://dx.doi.org/10.1007/s00424-009-0690-y
    Journal articles | 2009
    Dr Hartmut Cuny
    Griessmeier K; Cuny H; Rötzer K; Griesbeck O; Harz H; Biel M; Wahl-Schott C, 2009, 'Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels', Journal of Biological Chemistry, vol. 284, pp. 29809 - 29816, http://dx.doi.org/10.1074/jbc.M109.048082
    Journal articles | 2007
    Dr Hartmut Cuny
    Wahl-Schott C; Cuny H; Eckert C; Grießmeier K; Gebhard M; Biel M, 2007, 'Retinal calcium channels: Loss: of calcium signals in the retina leads to night blindness', BioSpektrum, vol. 13, pp. 29 - 31
    Journal articles | 2006
    Dr Hartmut Cuny
    Wahl-Schott C; Baumann L; Cuny H; Eckert C; Griessmeier K; Biel M, 2006, 'Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 15657 - 15662, http://dx.doi.org/10.1073/pnas.0604621103

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