Dr Hartmut Cuny

Yang A; Alankarage D; Cuny H; Ip EKK; Almog M; Lu J; Das D; Enriquez A; Szot JO; Humphreys DT; Blue GM; Ho JWK; Winlaw DS; Dunwoodie SL; Giannoulatou E, 2022, 'CHDgene: A Curated Database for Congenital Heart Disease Genes', Circulation: Genomic and Precision Medicine, vol. 15, pp. E003539 - E003539, http://dx.doi.org/10.1161/CIRCGEN.121.003539

Cuny H; Kristianto E; Hodson MP; Dunwoodie SL, 2021, 'Simultaneous quantification of 26 NAD-related metabolites in plasma, blood, and liver tissue using UHPLC-MS/MS', Analytical Biochemistry, vol. 633, pp. 114409, http://dx.doi.org/10.1016/j.ab.2021.114409

Cuny H; Rapadas M; Gereis J; Martin EMMA; Kirk RB; Shi H; Dunwoodie SL, 2020, 'NAD deficiency due to environmental factors or gene–environment interactions causes congenital malformations and miscarriage in mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 3738 - 3747, http://dx.doi.org/10.1073/pnas.1916588117

Szot JO; Campagnolo C; Cao Y; Iyer KR; Cuny H; Drysdale T; Flores-Daboub JA; Bi W; Westerfield L; Liu P; Leung TN; Choy KW; Chapman G; Xiao R; Siu VM; Dunwoodie SL, 2020, 'Bi-allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders', American Journal of Human Genetics, vol. 106, pp. 129 - 136, http://dx.doi.org/10.1016/j.ajhg.2019.12.006

Alankarage D; Ip E; Szot JO; Munro J; Blue GM; Harrison K; Cuny H; Enriquez A; Troup M; Humphreys DT; Wilson M; Harvey RP; Sholler GF; Graham RM; Ho JWK; Kirk EP; Pachter N; Chapman G; Winlaw DS; Giannoulatou E; Dunwoodie SL, 2019, 'Identification of clinically actionable variants from genome sequencing of families with congenital heart disease', Genetics in Medicine, vol. 21, pp. 1111 - 1120, http://dx.doi.org/10.1038/s41436-018-0296-x

Cuny H; Yu R; Tae HS; Kompella SN; Adams DJ, 2018, 'α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition', British Journal of Pharmacology, vol. 175, pp. 1855 - 1868, http://dx.doi.org/10.1111/bph.13852

Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation. Genomic and precision medicine, vol. 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978

Cuny H; Kompella SN; Tae HS; Yu R; Adams DJ, 2016, 'Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins', Journal of Biological Chemistry, vol. 291, pp. 23779 - 23792, http://dx.doi.org/10.1074/jbc.M116.730804

Huynh TG; Cuny H; Slesinger PA; Adams DJ, 2015, 'Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABAB receptor', Molecular Pharmacology, vol. 87, pp. 240 - 250, http://dx.doi.org/10.1124/mol.114.096156

Kompella SN; Cuny H; Hung A; Adams DJ, 2015, 'Molecular basis for differential sensitivity of α-conotoxin RegIIA at rat and human neuronal nicotinic acetylcholine receptors', Molecular Pharmacology, vol. 88, pp. 993 - 1001, http://dx.doi.org/10.1124/mol.115.100503

Berecki G; McArthur JR; Cuny H; Clark RJ; Adams DJ, 2014, 'Differential Ca(V)2.1 and Ca(V)2.3 Channel Inhibition by Baclofen and alpha-Conotoxin Vc1.1 via GABA(B) Receptor Activation', BIOPHYSICAL JOURNAL, vol. 106, pp. 330A - 330A, http://dx.doi.org/10.1016/j.bpj.2013.11.1896

Berecki G; McArthur JR; Cuny H; Clark RJ; Adams DJ, 2014, 'Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation', Journal of General Physiology, vol. 143, pp. 465 - 479, http://dx.doi.org/10.1085/jgp.201311104

Grimm C; Holdt LM; Chen CC; Hassan S; Müller C; Jörs S; Cuny H; Kissing S; Schröder B; Butz E; Northoff B; Castonguay J; Luber CA; Moser M; Spahn S; Lüllmann-Rauch R; Fendel C; Klugbauer N; Griesbeck O; Haas A; Mann M; Bracher F; Teupser D; Saftig P; Biel M; Wahl-Schott C, 2014, 'High susceptibility to fatty liver disease in two-pore channel 2-deficient mice', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms5699

Adams DJ; Harper AA; Grishin AA; Cuny H, 2013, 'Actions of α-conotoxins on neuronal nicotinic acetylcholine receptors and synaptic transmission in rat parasympathetic ganglia', Autonomic Neuroscience, vol. 177, pp. 306 - 306, http://dx.doi.org/10.1016/j.autneu.2013.08.027

Grishin AA; Cuny H; Hung A; Clark RJ; Brust A; Akondi K; Alewood PF; Craik DJ; Adams DJ, 2013, 'Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors', Journal of Biological Chemistry, vol. 288, pp. 34428 - 34442, http://dx.doi.org/10.1074/jbc.M113.512582

Inserra MC; Kompella SN; Vetter I; Brust A; Daly NL; Cuny H; Craik DJ; Alewood PF; Adams DJ; Lewis RJ, 2013, 'Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors', Biochemical Pharmacology, vol. 86, pp. 791 - 799, http://dx.doi.org/10.1016/j.bcp.2013.07.016

Yasuda T; Cuny H; Adams DJ, 2013, 'Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation', Journal of Physiology, vol. 591, pp. 2579 - 2591, http://dx.doi.org/10.1113/jphysiol.2012.249151

Cuny H; De Faoite A; Huynh TG; Yasuda T; Berecki G; Adams DJ, 2012, 'γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins', Journal of Biological Chemistry, vol. 287, pp. 23948 - 23957, http://dx.doi.org/10.1074/jbc.M112.342998

Griessmeier K; Cuny H; Rötzer K; Griesbeck O; Harz H; Biel M; Wahl-Schott C, 2009, 'Calmodulin is a functional regulator of Cav1.4 L-type Ca²⁺ channels', Journal of Biological Chemistry, vol. 284, pp. 29809 - 29816, http://dx.doi.org/10.1074/jbc.M109.048082

Zong X; Schieder M; Cuny H; Fenske S; Gruner C; Rötzer K; Griesbeck O; Harz H; Biel M; Wahl-Schott C, 2009, 'The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores', Pflugers Archiv European Journal of Physiology, vol. 458, pp. 891 - 899, http://dx.doi.org/10.1007/s00424-009-0690-y

Wahl-Schott C; Cuny H; Eckert C; Grießmeier K; Gebhard M; Biel M, 2007, 'Retinal calcium channels: Loss: of calcium signals in the retina leads to night blindness', BioSpektrum, vol. 13, pp. 29 - 31

Wahl-Schott C; Baumann L; Cuny H; Eckert C; Griessmeier K; Biel M, 2006, 'Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 15657 - 15662, http://dx.doi.org/10.1073/pnas.0604621103