Dr Helder Marcal
Adjunct Associate Professor

Dr Helder Marcal

Engineering
Grad Sch: Biomedical Eng

Dr Helder Marçal is an international recognized expert in Biopharmaceutical Engineeringtissue engineering and Regenerative medicine technologies using stem cells. His research spans multidisciplinary fields of Biomedical Engineering, Theranostics, Biomaterials, Tissue regeneration in space, Biogerontology and Autoimmunity

 

Dr Marcal is translating biomedical applications for the treatment of autoimmune arthritis (spondyloarthritis) and type 1 diabetes. In autoimmune arthritis, these are associated with with the HLA-B27 phenotype that causes the susceptibility for autoimmune tissue destruction. Dr Marcal has identified the mechanism of how tissue destruction is enabled. This technology leads the field for the development of a bona fide biotherapeutic to help halt the immuno-pathogenesis of these conditions. Dr. Marçal has been a finalist for inventor of the year UNSW Australia. His research has been highlighted at the Powerhouse Museum, The Sydney Morning Herald, National Geographic, Discovery Channel, ABC Catalyst, The Sunday Telegraph, NASA TVNew York Times, to name a few.

 

Dr. Marçal completed post doctorate studies at the McGowan Regenerative Medicine Institute in the USA. He has established international collaborations involving these technologies in the field of regenerative and translational medicine and presents at numerous international conferences. Dr. Marçal’s knowledge and skills span across innovative areas and he holds 7 patents in these fields. Dr. Helder Marcal specializes in tissue regeneration in Space Medicine and the impact of space travel on human physiology (mission to Mars) especially, the impact of microgravity and its effect on stem cells and tissue regeneration. Dr. Marcal introduced the area of Bioastronautics to Australia at the Powerhouse Museum in 2000 in collaboration with NASA. He has been a visiting fellow at Harvard-MIT Health Sciences and Technology, Australian Regenerative Medicine Instituteand the California Institute for Regenerative Medicine (CIRM).

  • Journal articles | 2018
    Mello FD; Braidy N; Marçal H; Guillemin G; Nabavi SM; Neilan BA, 2018, 'Mechanisms and Effects Posed by Neurotoxic Products of Cyanobacteria/Microbial Eukaryotes/Dinoflagellates in Algae Blooms: a Review', Neurotoxicity Research, vol. 33, pp. 153 - 167, http://dx.doi.org/10.1007/s12640-017-9780-3
    Journal articles | 2017
    D‘Mello F; Braidy N; Marçal H; Guillemin G; Rossi F; Chinian M; Laurent D; Teo C; Neilan BA, 2017, 'Cytotoxic Effects of Environmental Toxins on Human Glial Cells', Neurotoxicity Research, vol. 31, pp. 245 - 258, http://dx.doi.org/10.1007/s12640-016-9678-5
    Journal articles | 2015
    Chiu AS; Braidy N; Marçal H; Welch JH; Gehringer MM; Guillemin GJ; Neilan BA, 2015, 'Global cellular responses to β-methyl-amino-l-alanine (BMAA) by olfactory ensheathing glial cells (OEC)', Toxicon, vol. 99, pp. 136 - 145, http://dx.doi.org/10.1016/j.toxicon.2015.03.009
    Journal articles | 2015
    Foster LJR; Ho S; Hook J; Basuki M; Marçal H, 2015, 'Chitosan as a biomaterial: Influence of degree of deacetylation on its physiochemical, material and biological properties', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0135153
    Journal articles | 2015
    Hasse B; Tarr PE; Marques-Vidal P; Waeber G; Preisig M; Mooser V; Valeri F; Djalali S; Andri R; Bernasconi E; Calmy A; Cavassini M; Vernazza P; Battegay M; Weber R; Senn O; Vollenweider P; Ledergerber B; CoLaus Cohort, FIRE and the Swiss HIV Cohort Study ; Aubert V; Barth J; Battegay M; Bernasconi E; Böni J; Bucher HC; Burton-Jeangros C; Calmy A; Cavassini M; Egger M; Elzi L; Fehr J; Fellay J; Furrer H; Fux CA; Gorgievski M; Günthard H; Haerry D; Hasse B; Hirsch HH; Hösli I; Kahlert C; Kaiser L; Keiser O; Klimkait T; Kouyos R; Kovari H; Ledergerber B; Martinetti G; Martinez de Tejada B; Metzner K; Müller N; Nadal D; Pantaleo G; Rauch A; Regenass S; Rickenbach M; Rudin C; Schöni-Affolter F; Schmid P; Schultze D; Schüpbach J; Speck R; Staehelin C; Tarr P; Telenti A; Trkola A; Vernazza P; Weber R; Yerly S; Jean-Michel A; Murielle B; Jean Michel G; Christoph H; Thomas L; Pedro MV; Vincent M; Fred P; Martin P; Peter V; Roland VK; Aidacic V; Gerard W; Jürg B; Markus B; Heinz B; Martin B; Hans-Ulrich B; Ivo B; Reto C; Isabelle C; Corinne C; Sima D; Peter D; Simone E; Andrea F; Markus F; Claudius F; Jakob F; Ali GM; Matthias G; Denis H; Marcel H; Walter H; Simon H; Felix H; Paul H; Eva K; Vladimir K; Daniel K; Stephan K; Beat K; Benedict K; Heidi K; Vesna L; Giovanni L; Werner LH; Phillippe L; Severin L; Christoph M; Jürgen M; Damian M; Werner M; Titus M; Valentina N; Jakob R; Thomas R; Hana S; Frank S; Georg S; Oliver S; Pietro S; Jacques S; Alfred S; Alois S; Claudia S; Othmar S; Phuoc TT; Marco V; Alessandro V; René VA; Hans W; Fritz W; Johanna W-S; Joseph W; Marco Z, 2015, 'Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population.', Open Forum Infect Dis, vol. 2, pp. ofv108, http://dx.doi.org/10.1093/ofid/ofv108
    Journal articles | 2014
    Chan RTH; Russell RA; Marçal H; Lee TH; Holden PJ; Foster LJR, 2014, 'BioPEGylation of polyhydroxybutyrate promotes nerve cell health and migration', Biomacromolecules, vol. 15, pp. 339 - 349, http://dx.doi.org/10.1021/bm401572a
    Journal articles | 2014
    Ho S; Marçal H; Foster LJR, 2014, 'Towards scarless wound healing: A comparison of protein expression between human, adult and foetal fibroblasts', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/676493