Dr Helder   Marcal
Adjunct Associate Professor

Dr Helder Marcal

Grad Sch: Biomedical Eng

Dr Helder Marçal is an international recognized expert in tissue engineering and regenerative medicine technologies using stem cells. His research spans multidisciplinary fields of Biomedical Engineering, Theranostics, Stem Cell therapeutics, Biosurveillance, Biomaterials, Tissue regeneration in space and Biogerontology.


Dr Marcal is also translating biomedical applications in autoimmune arthritis (spondyloarthritis). These inflammatory arthritis conditions associated with individuals that are positive for the HLA-B27 phenotype and susceptible for autoimmune tissue destruction. This technology leads the field for the development of a biotherapeutic to help halt the immuno-pathogenesis of these conditions. Dr. Marçal has been a finalist for inventor of the year UNSW Australia. His research has been highlighted at the Powerhouse Museum, The Sydney Morning Herald, National Geographic, Discovery Channel, ABC Catalyst, The Sunday Telegraph, NASA TVNew York Times, to name a few.


He has established international collaborations involving these technologies in the field of regenerative and translational medicine and presents at numerous international conferences. Dr. Marçal’s knowledge and skills span across innovative areas and he holds 7 patents in these fields. Dr. Helder Marcal specializes in tissue regeneration in Space Medicine and the impact of space travel on human physiology (mission to Mars) especially, the impact of microgravity and its effect on stem cells and tissue regeneration. Dr. Marcal introduced the area of Bioastronautics to Australia at the Powerhouse Museum in collaboration with NASA. He has been a visiting fellow at Harvard-MIT Health Sciences and Technology, McGowan Institute for Regenerative Medicine, Center for iPS Cell Research and Application and the California Institute for Regenerative Medicine (CIRM).


  • Book Chapters | 2012
    Marcal H; Wanandy NS; Castellano-Gonzalez G; Braidy N; Guillemin GJ, 2012, 'Curcumin: Medicinal Properties, Molecular Targets and Biological Mechanisms', in Sasaki J; Kichida M (ed.), Curcumin: Biosynthesis, Medicinal Uses and Health Benefits, Nova, pp. 133 - 154, https://www.novapublishers.com/catalog/product_info.php?products_id=30913&osCsid=;%20https://www.novapublishers.com/catalog/product_info.php?products_id=35977
  • Journal articles | 2021
    Marcal H, 2021, 'Critical Perspectives on Cultural Memory and Heritage: Construction, Transformation and Destruction', JOURNAL OF THE INSTITUTE OF CONSERVATION, vol. 44, pp. 153 - 155, http://dx.doi.org/10.1080/19455224.2021.1929579
    Journal articles | 2021
    Marçal H, 2021, 'Becoming Difference: On the Ethics of Conserving the In-Between', Studies in Conservation, http://dx.doi.org/10.1080/00393630.2021.1947074
    Journal articles | 2019
    Lawson L; Finbow A; Marçal H, 2019, 'Developing a strategy for the conservation of performance-based artworks at Tate', Journal of the Institute of Conservation, vol. 42, pp. 114 - 134, http://dx.doi.org/10.1080/19455224.2019.1604396
    Journal articles | 2018
    Mello FD; Braidy N; Marçal H; Guillemin G; Nabavi SM; Neilan BA, 2018, 'Mechanisms and Effects Posed by Neurotoxic Products of Cyanobacteria/Microbial Eukaryotes/Dinoflagellates in Algae Blooms: a Review', Neurotoxicity Research, vol. 33, pp. 153 - 167, http://dx.doi.org/10.1007/s12640-017-9780-3
    Journal articles | 2018
    Marçal H; Nogueira A; Macedo R, 2018, 'Materializing the intangible: The documentation of "Luís Vaz 73" (1975), by Jorge Peixinho and Ernesto de Sousa', Conservar Patrimonio, pp. 13 - 22, http://dx.doi.org/10.14568/cp2016042
    Journal articles | 2017
    D‘Mello F; Braidy N; Marçal H; Guillemin G; Rossi F; Chinian M; Laurent D; Teo C; Neilan BA, 2017, 'Cytotoxic Effects of Environmental Toxins on Human Glial Cells', Neurotoxicity Research, vol. 31, pp. 245 - 258, http://dx.doi.org/10.1007/s12640-016-9678-5
    Journal articles | 2016
    Castellano-González G; Pichaud N; Ballard JWO; Bessede A; Marcal H; Guillemin GJ, 2016, 'Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes', Oncotarget, vol. 7, pp. 7426 - 7440, http://dx.doi.org/10.18632/oncotarget.6863
    Journal articles | 2016
    Hassarati RT; Marcal H; John L; Foster R; Green RA, 2016, 'Biofunctionalization of conductive hydrogel coatings to support olfactory ensheathing cells at implantable electrode interfaces', Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 104, pp. 712 - 722, http://dx.doi.org/10.1002/jbm.b.33497
    Journal articles | 2015
    Hasse B; Tarr PE; Marques-Vidal P; Waeber G; Preisig M; Mooser V; Valeri F; Djalali S; Andri R; Bernasconi E; Calmy A; Cavassini M; Vernazza P; Battegay M; Weber R; Senn O; Vollenweider P; Ledergerber B; CoLaus Cohort, FIRE and the Swiss HIV Cohort Study ; Aubert V; Barth J; Battegay M; Bernasconi E; Böni J; Bucher HC; Burton-Jeangros C; Calmy A; Cavassini M; Egger M; Elzi L; Fehr J; Fellay J; Furrer H; Fux CA; Gorgievski M; Günthard H; Haerry D; Hasse B; Hirsch HH; Hösli I; Kahlert C; Kaiser L; Keiser O; Klimkait T; Kouyos R; Kovari H; Ledergerber B; Martinetti G; Martinez de Tejada B; Metzner K; Müller N; Nadal D; Pantaleo G; Rauch A; Regenass S; Rickenbach M; Rudin C; Schöni-Affolter F; Schmid P; Schultze D; Schüpbach J; Speck R; Staehelin C; Tarr P; Telenti A; Trkola A; Vernazza P; Weber R; Yerly S; Jean-Michel A; Murielle B; Jean Michel G; Christoph H; Thomas L; Pedro MV; Vincent M; Fred P; Martin P; Peter V; Roland VK; Aidacic V; Gerard W; Jürg B; Markus B; Heinz B; Martin B; Hans-Ulrich B; Ivo B; Reto C; Isabelle C; Corinne C; Sima D; Peter D; Simone E; Andrea F; Markus F; Claudius F; Jakob F; Ali GM; Matthias G; Denis H; Marcel H; Walter H; Simon H; Felix H; Paul H; Eva K; Vladimir K; Daniel K; Stephan K; Beat K; Benedict K; Heidi K; Vesna L; Giovanni L; Werner LH; Phillippe L; Severin L; Christoph M; Jürgen M; Damian M; Werner M; Titus M; Valentina N; Jakob R; Thomas R; Hana S; Frank S; Georg S; Oliver S; Pietro S; Jacques S; Alfred S; Alois S; Claudia S; Othmar S; Phuoc TT; Marco V; Alessandro V; René VA; Hans W; Fritz W; Johanna W-S; Joseph W; Marco Z, 2015, 'Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population.', Open Forum Infect Dis, vol. 2, pp. ofv108, http://dx.doi.org/10.1093/ofid/ofv108
    Journal articles | 2015
    Foster LJR; Ho S; Hook J; Basuki M; Marçal H, 2015, 'Chitosan as a biomaterial: Influence of degree of deacetylation on its physiochemical, material and biological properties', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0135153
    Journal articles | 2015
    Chiu AS; Braidy N; Marçal H; Welch JH; Gehringer MM; Guillemin GJ; Neilan BA, 2015, 'Global cellular responses to β-methyl-amino-l-alanine (BMAA) by olfactory ensheathing glial cells (OEC)', Toxicon, vol. 99, pp. 136 - 145, http://dx.doi.org/10.1016/j.toxicon.2015.03.009
    Journal articles | 2014
    Ho S; Marçal H; Foster LJR, 2014, 'Towards scarless wound healing: A comparison of protein expression between human, adult and foetal fibroblasts', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/676493
    Journal articles | 2014
    Chan RTH; Russell RA; Marçal H; Lee TH; Holden PJ; Foster LJR, 2014, 'BioPEGylation of polyhydroxybutyrate promotes nerve cell health and migration', Biomacromolecules, vol. 15, pp. 339 - 349, http://dx.doi.org/10.1021/bm401572a
    Journal articles | 2013
    Chan RTZ; Marcal H; Ahmed T; Holden PJ; Foster LJ, 2013, 'Poly(ethylene glycol)-modulated cellular biocompatibility of polyhydroxyalkanoate films', Polymer International, vol. 62, pp. 884 - 892, http://dx.doi.org/10.1002/pi.4451
    Journal articles | 2013
    Ralf K; Mathias E; Marcel H; Friedrich C; Jörg B, 2013, 'The relationship of is and law - the perspective of and implications for is research', ECIS 2013 - Proceedings of the 21st European Conference on Information Systems
    Journal articles | 2012
    Marcal H; Ahmed T; Badylak S; Tottey S; Foster LJ, 2012, 'A comprehensive protein expression profile of extracellular matrix biomaterial derived from porcine urinary bladder', Regenerative Medicine, vol. 7, pp. 159 - 166, http://dx.doi.org/10.2217/rme.12.6
    Journal articles | 2012
    Chan TH; Marcal H; Russell RA; Holden PJ; Foster LJR, 2012, 'Polyhydroxybutyrate and polyethylene glycol composites as biomaterials for biomedical applications', JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, pp. 208 - 208, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308313001372&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Thomson KA; Marcal H; Shahbazi J; Watson SL; Wakefield D; Foster LJ, 2012, 'SurgiLux: a novel thin film, laser-activated bioadhesive for corneal repair', Advanced Materials Research, vol. 506, pp. 7 - 10, http://dx.doi.org/10.4028/www.scientific.net/AMR.506.7
    Journal articles | 2012
    Marcal H; Ahmed T; Wanandy NS; Foster LJ, 2012, 'Spinal cord repair and regeneration: the application of bioadhesives and extracellular matrix bioscaffolds', Advanced Materials Research, vol. 506, pp. 19 - 22, http://dx.doi.org/10.4028/www.scientific.net/AMR.506.19
    Journal articles | 2011
    Chan R; Marcal H; Russell RA; Holden PJ; Foster LJ, 2011, 'Application of polyethylene glycol to promote cellular biocompatibility of polyhydroxybutyrate films', International Journal of Polymer Science, vol. 2011, pp. 1 - 9, http://dx.doi.org/10.1155/2011/473045
    Journal articles | 2011
    Chan R; Garvey C; Marcal H; Russell RA; Holden PJ; Foster LJ, 2011, 'Manipulation of polyhydroxybutyrate properties through blending with ehtyl-cellulose for a composite biomaterial', International Journal of Polymer Science, vol. 2011, pp. 1 - 8, http://dx.doi.org/10.1155/2011/651549
    Journal articles | 2011
    Shahbazi J; Marcal H; Watson SL; Wakefield D; Sarris M; Foster LJ, 2011, 'Sutureless sealing of penetrating corneal wounds using a laser-activated thin film adhesive', Lasers in Surgery and Medicine, vol. 43, pp. 490 - 498, http://dx.doi.org/10.1002/lsm.21076
    Journal articles | 2010
    Foster LJ; Thomson KA; Marcal H; Butt J; Watson SL; Wakefield D, 2010, 'Chitosan-vancomysin composite biomaterial as a laser activated surgical adhesive with regional antimicrobial activity', Biomacromolecules, vol. 11, pp. 3563 - 3570, http://dx.doi.org/10.1021/bm101028g
    Journal articles | 2008
    Marcal H; Wanandy NS; Sanguanchaipaiwong V; Woolnough CA; Lauto A; Mahler SM; Foster LJ, 2008, 'BioPEGylation of Polyhydroxyalkanoates: Influence on Properties and Satellite-Stem Cell Cycle', Biomacromolecules, vol. 9, pp. 2719 - 2726, http://dx.doi.org/10.1021/bm800418e
    Journal articles | 2008
    Dinnes D; Marcal H; Raftery MJ; Labow R; Mahler SM, 2008, 'The macrophage-biomaterial interface: a proteomic analysis of the conditioned medium environment', Journal of Chemical Technology and Biotechnology, vol. 83, pp. 482 - 495, http://dx.doi.org/10.1002/jctb.1854
    Journal articles | 2008
    Marcal H; Sarris M; Raftery MJ; Bhasin V; McFarland CD; Mahler SM, 2008, 'Expression proteomics of olfactory ensheathing cells', Journal of Chemical Technology and Biotechnology, vol. 83, pp. 473 - 481, http://dx.doi.org/10.1002/jctb.1900
    Journal articles | 2008
    Marcal H; Badylak SF; Sellaro TL; Lauto A; Mahler SM; Foster LJ, 2008, 'The Coalescence of decellularised Tissue Scaffolds, Laser Activated Chitosan Bioadhesive and Olfactory Ensheathing Cells for Tissue Repair and Regeneration of the Spinal Cord', Lasers in Medical Science, vol. 23, pp. 96 - 97
    Journal articles | 2007
    Prowse AB; Mcquade LR; Bryant KJ; Marcal H; Gray PP, 2007, 'Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media', Journal of Proteome Research, vol. 6, pp. 3796 - 3807, http://dx.doi.org/10.1021/pr0702262
    Journal articles | 2007
    Dinnes D; Marcal H; Mahler SM; Santerre J; Labow R, 2007, 'Material surfaces affect the protein expression patterns of human macrophages: a proteomics approach', Journal of Biomedical Materials Research Part A, vol. 80A, pp. 895 - 908, http://dx.doi.org/10.1002/jbm.a.30967
    Journal articles | 2007
    Lauto A; Stoodley MA; Marcal H; Avolio AP; Sarris M; McKenzie GL; Sampson D; Foster LJ, 2007, 'In Vitro and In Vivo Tissue Repair with Laser - Activated Chitosan Adhesive', Lasers in Surgery and Medicine, vol. 39, pp. 19 - 27, http://dx.doi.org/10.1002/lsm.20418
    Journal articles | 2007
    Lauto A; Stoodley MA; Marcal H; Avolio AP; Sarris M; McKenzie GL; Sampson D; Foster LJ, 2007, 'Tissue repair with laser-activated chitosan adhesive: in vitro and in vivo study', Lasers in Surgery and Medicine, vol. 39, pp. 19 - 27, http://dx.doi.org/10.1002/lsm.20418
    Journal articles | 2006
    Marcal H; Sarris M; Mackay-Sim A; Mahler SM, 2006, 'Regenerative medicine applications using olfactory ensheathing cells: The role of neurotrophic factors', Histopathology, vol. 29, pp. 188 - 200
    Journal articles | 2006
    Marcal H; Raftery MJ; Sarris M; McKenzie GL, 2006, 'Secretome analysis of olfactory ensheathing cells for use in tissue engineering and regenerative medicine applications', Molecular and Cellular Proteomics, vol. 5 :S92/410 supl. S, pp. S92 - S92, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000241506400211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2003
    Mahler SM; Chin DW; Van Dyk DD, 2003, 'The application of emerging technologies in genomics and proteomics to drug development', Journal of Pharmacy Practice and Research, vol. 33, pp. 7 - 11
    Journal articles | 1999
    Vannarat S; Sluiter MHF; Kawazoe Y, 1999, 'Effect of lattice coherency on solution energies of impurities: Stability of an epitaxial InAs monolayer deposited on GaAs', Materials Transactions, JIM, vol. 40, pp. 1295 - 1300, http://dx.doi.org/10.2320/matertrans1989.40.1295
    Journal articles | 1999
    Mead T; Drowatzky JN; Marcal H, 1999, 'Reaction and movement times of elementary school children aged 7 to 12 years', Clinical Kinesiology, vol. 53, pp. 83 - 90
    Journal articles | 1996
    Van de Voorde MH; Nedele MR, 1996, 'CMC's research in Europe and the future potential of CMC's in industry', Ceramic Engineering and Science Proceedings, vol. 17, pp. 3 - 21
    Journal articles | 1996
    Sluiter MHF; Esfarjani K; Kawazoe Y, 1996, 'Phase stability of the sigma phase in Fe-Cr based alloys', Materials Research Society Symposium - Proceedings, vol. 408, pp. 369 - 374
    Journal articles | 1995
    Van Aert HAM; Venderbosch RW; Lemstra PJ; Van Genderen MHP; Meijer EW, 1995, 'Controlled molecular weight by the precipitation polymerization of 2,6-dimethylphenol', Journal of Macromolecular Science, Part A, vol. 32, pp. 515 - 523, http://dx.doi.org/10.1080/10601329508013680
    Journal articles | 1995
    Cobianu C; Rem JB; Klootwijk JH; Weusthof MHH; Holleman J; Woerlee PH, 1995, 'LPCVD SiO2 layers prepared from SiH4 and O2 at 450 °C in a RTP', Proceedings of the International Semiconductor Conference, CAS, pp. 319 - 322
    Journal articles | 1987
    Sassiat PR; Mourier P; Caude MH; Rosset RH, 1987, 'Measurement of Diffusion Coefficients in Supercritical Carbon Dioxide and Correlation with the Equation of Wilke and Chang', Analytical Chemistry, vol. 59, pp. 1164 - 1170, http://dx.doi.org/10.1021/ac00135a020
    Journal articles | 1983
    Journal articles | 1982
    Leroux MH, 1982, 'NEW APPROACH TO THE MACHINE CONTROLLER, THE MODULAR FUNCTION ORIENTED MULTIPROCESSOR NC SYSTEM.', Proceedings of the Annual Meeting and Technical Conference - Numerical Control Society, pp. 106 - 115
  • Patents | 2019
    Conference Papers | 2018
    Schneider J; Kaiser D; Morgana N; Marcel H; Feick H, 2018, 'Revival of grayscale technique in power semiconductor processing under low-cost manufacturing constraints', in Behringer UFW; Finders J (ed.), 34TH EUROPEAN MASK AND LITHOGRAPHY CONFERENCE, SPIE-INT SOC OPTICAL ENGINEERING, Grenoble, FRANCE, presented at 34th European Mask and Lithography Conference, Grenoble, FRANCE, 18 June 2018 - 20 June 2018, http://dx.doi.org/10.1117/12.2326006
    Conference Abstracts | 2018
    Naber J; Schwab S; Setinek U; Krenbek D; Marcel H; Fabikan H; Watzka S; Koger R; Fazekase A; Bitterlich E; Valipour A; Burghuber OC; Hochmair MJ, 2018, 'Real-life experience with Brigatinib in pretreated EML4-ALK translocated NSCLC patients', in WIENER KLINISCHE WOCHENSCHRIFT, SPRINGER WIEN, Vol. 130, pp. 617 - 618, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448081200063&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2017
    Marcel H; Dirk W; Bernd G; Heike IG; Daisy N, 2017, 'Development of nonwoven preforms made of pure recycled carbon fibres (rCF) for applications of composite materials', in Key Engineering Materials, Bremen; Germany, pp. 555 - 561, presented at 21st Symposium on Composites, 2017, Bremen; Germany, 05 July 2017 - 07 July 2017, http://dx.doi.org/10.4028/www.scientific.net/KEM.742.555
    Conference Papers | 2007
    Marcal H; Lauto A; Badylak SF; Sellaro TL; Mackay-Sim A; Foster LJ, 2007, 'Laser-activated bioadhesive with decellularized tissue scaffolds and olfactory ensheathing cells may enhance repair and regeneration of injured spinal cords', in Laser-activated bioadhesive with decellularized tissue scaffolds and olfactory ensheathing cells may enhance repair and regeneration of injured spinal cords, 17th International Congress, International Society Laser Medicine and Surgery, Florence, Italy, presented at 17th International Congress, International Society Laser Medicine and Surgery, Florence, Italy, 08 November 2007 - 10 November 2007
    Patents | 2007
    Marcal H, 2007, Methods and composition for ocular regeneration V, Australia, Patent No. , Patent Agent:Spruson and Furgerson patent attorneys
    Patents | 2006
    Marcal H, 2006, Tissue Regeneration III, New Zealand, Patent No. , Patent Agent:Freehills, Patent & Trademark Attorneys, Sydney, Australia
    Patents | 2006
    Marcal H, 2006, Tissue Regeneration IV, New Zealand, Patent No. , Patent Agent:Freehills, Patent & Trademark Attorneys, Sydney, Australia
    Conference Presentations | 2005
    Marcal H; Dinnes D; Raftery MJ; Labow R; McFarland CD; Santerre J; Mahler SM, 2005, 'The effect of material chemistry on cellular morphology and membrane surface-interface proteins: An innovative explorative proteomics technique', presented at 8th Annual Meeting of Tissue Engineering Society International, Shanghai, P.R. China, 22 October 2005 - 25 October 2005
    Patents | 2005
    Marcal H, 2005, Tissue Regeneration I, New Zealand, Patent No. WIPO PCT Application WO06/108218, Patent Agent:Freehills, Patent & Trademark Attorneys, Sydney, Australia
    Conference Proceedings (Editor of) |