Dr Holly   Holliday
Conjoint Associate Lecturer

Dr Holly Holliday

medicine-health
Sch Women's&Children's Health

Dr Holliday is a cell and molecular biologist interested in epigenetics, gene regulation and paediatric cancer therapeutics. In 2014 she completed a Bachelor of Medical Science majoring in Biochemistry at USyd, graduating with first class honours and the university medal. In 2018 Dr Holliday graduated with a PhD from the Garvan Institute of Medical Research and the University of New South Wales. During her candidature she investigated the helix-loop-helix transcription factor ID4 in mammary gland development. She then undertook a post-doctoral position at the Garvan Institute, researching the therapeutic potential and mechanism of candidate microRNAs in neuroblastoma. She is now based at the Children’s Cancer Institute in the Brain Tumour group where she is investigating the molecular mechanism of epigenetic targeted therapies in Diffuse Intrinsic Pontine Glioma (DIPG).

Location
Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia Randwick 2031 Australia

Publications

  • Journal articles | 2021
    Dr Holly Holliday
    Holliday H; Khoury A; Swarbrick A, 2021, 'Chromatin immunoprecipitation of transcription factors and histone modifications in Comma-Dβ mammary epithelial cells', STAR Protocols, vol. 2, http://dx.doi.org/10.1016/j.xpro.2021.100514
    Journal articles | 2021
    Dr Holly Holliday
    Holliday H; Roden D; Junankar S; Wu SZ; Baker LA; Krisp C; Chan CL; McFarland A; Skhinas JN; Cox TR; Pal B; Huntington ND; Ormandy CJ; Carroll JS; Visvader J; Molloy MP; Swarbrick A, 2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', iScience, vol. 24, pp. 102072 - 102072, http://dx.doi.org/10.1016/j.isci.2021.102072
    Journal articles | 2021
    Dr Holly Holliday
    McEvoy CR; Holliday H; Thio N; Mitchell C; Choong DY; Yellapu B; Leong HS; Xu H; Lade S; Browning J; Takano EA; Byrne DJ; Gill AJ; Duong CP; Li J; Fellowes AP; Fox SB; Swarbrick A; Prall OWJ, 2021, 'A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors', Laboratory Investigation, vol. 101, pp. 26 - 37, http://dx.doi.org/10.1038/s41374-020-00484-3
    Journal articles | 2020
    Dr Holly Holliday
    Thankamony AP; Murali R; Karthikeyan N; Varghese BA; Teo WS; McFarland A; Roden DL; Holliday H; Konrad CV; Cazet A; Dodson E; Yang J; Baker LA; George JT; Levine H; Jolly MK; Swarbrick A; Nair R, 2020, 'Targeting the id1-kif11 axis in triple-negative breast cancer using combination therapy', Biomolecules, vol. 10, pp. 1 - 15, http://dx.doi.org/10.3390/biom10091295
    Journal articles | 2020
    Dr Holly Holliday
    Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, vol. 39, http://dx.doi.org/10.15252/embj.2019104063
    Journal articles | 2020
    Dr Holly Holliday
    Teo WS; Holliday H; Karthikeyan N; Cazet AS; Roden DL; Harvey K; Konrad CV; Murali R; Varghese BA; Thankamony AP; Chan CL; McFarland A; Junankar S; Ye S; Yang J; Nikolic I; Shah JS; Baker LA; Millar EKA; Naylor MJ; Ormandy CJ; Lakhani SR; Kaplan W; Mellick AS; O'Toole SA; Swarbrick A; Nair R, 2020, 'Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1', Frontiers in Cell and Developmental Biology, vol. 8, http://dx.doi.org/10.3389/fcell.2020.00552
    Journal articles | 2020
    Dr Holly Holliday
    Baker LA; Holliday H; Roden D; Roden D; Krisp C; Wu SZ; Junankar S; Serandour AA; Mohammed H; Nair R; Sankaranarayanan G; Law AMK; Law AMK; McFarland A; Simpson PT; Lakhani S; Dodson E; Selinger C; Anderson L; Anderson L; Samimi G; Hacker NF; Lim E; Lim E; Ormandy CJ; Naylor MJ; Simpson K; Nikolic I; O'Toole S; Kaplan W; Cowley MJ; Carroll JS; Molloy M; Swarbrick A, 2020, 'Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer', Breast Cancer Research, vol. 22, pp. 63, http://dx.doi.org/10.1186/s13058-020-01306-6
    Journal articles | 2020
    Dr Holly Holliday
    Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327
    Journal articles | 2018
    Dr Holly Holliday
    Holliday H; Baker LA; Junankar SR; Clark SJ; Swarbrick A, 2018, 'Epigenomics of mammary gland development', Breast Cancer Research, vol. 20, http://dx.doi.org/10.1186/s13058-018-1031-x
    Journal articles | 2016
    Dr Holly Holliday
    Baker LA; Holliday H; Swarbrick A, 2016, 'ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancer', Endocrine-Related Cancer, vol. 23, pp. R381 - R392, http://dx.doi.org/10.1530/ERC-16-0196
    Journal articles |
    Dr Holly Holliday
    Holliday H; Roden D; Junankar S; Wu SZ; Baker LA; Krisp C; Chan C-L; McFarland A; Skhinas JN; Cox TR; Pal B; Huntington N; Ormandy CJ; Carroll JS; Visvader J; Molloy MP; Swarbrick A, 'Inhibitor of Differentiation 4 (ID4) represses myoepithelial differentiation of mammary stem cells through its interaction with HEB', , http://dx.doi.org/10.1101/2020.04.06.026963

Awards

2020                            Prize for oral presentation at the St Vincent's Campus Post-doc Symposium

2019                            Best rapid-fire talk at Sydney Catalyst International Translational Cancer Research Symposium

2019                            Best rapid-fire talk at Sydney Catalyst Postgraduate and Early Career Researcher Symposium

2018                            Poster prize at EMBO Advances in Stem Cells and Regenerative Medicine Conference, Heidelberg, Germany

2018                            Poster prize at Australian Translational Breast Cancer Symposium,

2017                            Best student talk at ANZSCDB NSW Cells and Development Meeting

2017                            Poster prize at Lorne Cancer Conference

2017                            Poster prize at Australian Translational Breast Cancer Symposium

2014 – 2018              Australian Postgraduate Award Scholarship, valued at $25,392 p.a. (3.5 years)

2014 – 2018              UNSW Research Excellence Award, valued at $10,000 p.a. (3.5 years)

2013                            University of Sydney Medal for placing first in cohort

2013                            David J Monk Adams Award for academic proficiency in Physiology, valued at $1,500

2013                            Physiology Honours Scholarship, valued at $500

2012                            Dean’s List for Academic Excellence (High Distinction Average) and University of Sydney Merit Prize, valued at $1000

2011                            Dean’s List for Academic Excellence (High Distinction Average) and University of Sydney Merit Prize, valued at $1000

2010 – 2013              University of Sydney Access Scholarship, valued at $6,000 p.a. (4 years)

Grants

Media