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Professor Hongyuan (Robert) Yang

Professor Hongyuan (Robert) Yang

Adjunct Professor
Science
School of Biotech & Biomolecular Science

Education

  • Bachelor of Medicine (1993), Peking University Health Science Centre, Beijing, China
  • PhD (1998), Columbia University, New York, USA

Professional Experience

  • 2022-: NHMRC Investigator L3
  • 2014-2019: NHMRC Senior Research Fellow B
  • 2013-current: Professor, School of BABS
  • 2010-2013: Inaugural ARC Future Fellow
  • 2009-2012: Associate Professor, School of BABS
  • 2007-2008: Senior Lecturer, School of BABS, UNSW
  • 1999-2007: Lecturer/Assistant Professor/Associate Professor with tenure, Department of Biochemistry, National University of Singapore
  • 1999 (April-July): Visiting Fellow, Harvard University
  • Read this article on Rob's career by The Journal of Cell Biology https://doi.org/10.1083/jcb.202103075

Research Program and Contribution

Our long-term research interests focus on two fundamental yet emerging areas in cell and medical biology:

1.  Intracellular lipid (e.g., cholesterol and phosphatidylserine) sorting/transport, and its role in cancer, heart and neurodegenerative diseases.
2.  The biogenesis and dynamics of lipid droplets, adipocyte development, obesity and diabetes.

These two areas are closely linked because lipid droplets may play a crucial role in cellular lipid transport, and lipid droplets are a primary storage site for both free and esterified cholesterol.

Cellular lipid trafficking is a difficult subject to study given the lack of effective approaches to label lipids in live cells. However, it is an important cell biological question because lipids are actively sorted and transported in all eukaryotic cells. In addition, many human diseases such as atherosclerosis, Alzheimer’s and cancer are linked to aberrant lipid transport.

My early work led to the identification of two key enzymes that catalyze sterol esterification, an important homeostatic step for storing excess sterols (Yang et al., Science, 1996). Our laboratory subsequently identified novel molecules and schemes that govern cellular lipid transport (Wang et al., EMBO J, 2005; Du et al, J Cell Biol., 2011; Ghai et al, Nature Communications, 2017; Dong et al., Nat Comms, 2019; Wang et al., Molecular Cell, 2019; Du et al., JCB, 2020; Qian et al., Cell, 2020). Currently we aim to identify and characterize novel proteins that regulate the trafficking of cholesterol or phosphatidylserine between cellular organelles.

Lipid droplets are key cellular organelles that regulate energy storage and metabolism.  We have identified a number of factors that impact the size of lipid droplets (Fei et al, J Cell Biol., 2008; Fei et al, PLoS Genetics, 2011). One such protein, seipin, also plays an important role in human adipocyte development and maintenance (Cui et al., Human Mol Gen., 2011; Liu et al, Diabetes, 2014; Pagac et al, Cell Reports, 2016; Yan et al, Developmental Cell, 2018). Currently, we aim to understand how lipid droplets are formed from the ER and the exact role of seipin in this process.

Honours and Awards

  • NHMRC Investigator L3 (2022-2027)
  • UNSW Dean of Science Research Excellence Award (2019)
  • NHMRC Senior Research Fellowship B (2014-2019)
  • Inaugural ARC Future Fellowship (2010-2014)
  • Yong Loo Lin School of Medicine Research Excellence Young Scientist Award (2006)
  • Finalist, Singapore National Young Scientist Award (2005)
  • National University of Singapore (NUS) Technopreneurship 21 Award (2004)
  • National University of Singapore (NUS) Young Scientist Award (2002)

Editorial Service

  • Member of Editorial Board/Academic Editor, Journal of Cell Biology 
  • Member of Editorial Board, BBA-Molecular Cell Biology of Lipids

Selected Publications

 

Liu Y. and Yang H. (2024) WIPI4 loss linked to ferroptosis. Nature Cell Biol., 26: 506-507

Li YE, Norris DM, Xiao FN, Pandzic E, Whan RM, Fok S, Zhou M, Du G, Liu Y, Du X, Yang H. (2024) Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains. J Cell Biol; 223: e202307041.

Zadoorian A, Du X and Yang H. (2023) Lipid droplet biogenesis and functions in health and disease. Nature Reviews Endocrinology. https://doi.org/10.1038/s41574-023-00845-0

Lukmantara I, Chen F, Mak HY, Zadoorian A, Du X, Xiao FN, Norris DM, Pandzic E, Whan R, Zhong Q and Yang H. (2022) PI(3)P and DFCP1 regulate the biogenesis of lipid droplets. Mol Biol Cell. 33(14):ar131.

Mak HY, Ouyang Q, Tumanov S, Xu J, Rong P, Dong F, Lam SM, Wang X, Lukmantara I, Du X, Gao M, Brown AJ, Gong X, Shui G, Stocker R, Huang X, Chen S and Yang H. (2021) AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nature Communications. 12(1):6877. doi: 10.1038/s41467-021-27279-4.

Li YE, Wang Y, Du X, Zhang T, Mak HY, Hancock SE, McEwen H, Pandzic E, Whan RM, Aw YC, Lukmantara IE, Yuan Y, Dong X, Don A, Turner N, Qi S and Yang H. (2021)  TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine. Journal of Cell Biology; 220 (6), e202103105. Highlighted by Faculty Opinions https://facultyopinions.com/prime/740025624#tab=recommendations 

Yan R., Cao P., Song W., Qian H., Du X., Coates H.W., Zhao X., Li Y., Gao S., Gong X., Liu X., Sui J., Lei J., Yang H., Brown A.J., Zhou Q., Yan C. and Yan N. (2021) A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. SCIENCE, 371(6533):eabb2224. doi:10.1126/science.abb2224. 

Du X. and Yang H. (2021) Seipin regulates the formation of nuclear lipid droplets from a distance. Journal of Cell Biology; 220 (1): e202011166.

Qian H., Wu X., Du X., Yao X., Zhao X., Lee J., Yang H*, and Yan N*. (2020) Structural basis of low pH-dependent lysosomal cholesterol egress by NPC1 and NPC2. CELL, 182: 1-14.  * Co-corresponding authors.

Gao M., Liu L., Wang X., Mak H.Y., Liu G. and Yang H. (2020) GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Human Molecular Genetics. 1; 29: 432-443.

Du X., Zhou L., Aw Y.C., Mak H.Y., Xu Y., Rae J., Wang W., Zadoorian A., Hancock S.E., Osborne B., Chen X., Wu J.W., Turner N., Parton R.G., Li P. and Yang H. (2020) ORP5 Localizes to ER-Lipid Droplet Contacts and Regulates the Level of PI(4)P on Lipid Droplets. Journal of Cell Biology, 219, 1-16. Highlighted by JCB

Qian H., Zhao X., Yan R., Gao S., Sun X., Du X., Yang H., Wong CCL. and Yan N. (2020) Structural basis for catalysis and substrate specificity of human ACAT1. NATURE, 581: 333-338.

Luo J., Yang H. and Song B.L. (2020) Mechanisms and Regulation of Cholesterol Homeostasis. Nature Reviews Molecular Cell Biology. 21(4): 225-245. 

Wang H., Ma, Q., Qi, Y., Dong, J., Du, X., Rae, J., Brown A.J., Parton R.G., Wu J.W. and Yang H. (2019) ORP2 delivers cholesterol to the plasma membrane in exchange for phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P2). Molecular Cell, 73, 1–16. Cover Story. Highlighted by Nature Reviews

Gao M., Huang X., Song B.L. and Yang H. (2019) The biogenesis of lipid droplets: lipids take center stage. Progress in Lipid Research, 75: 100989. published online July 24th.

Dong J., Du X., Wang H., Wang J., Lu C., Chen X., Zhu Z., Luo Z., Yu L., Brown A.J., Yang H* and Wu JW*. (2019) Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nature Communications, 10: 829. * co-corresponding authors. 

Xu Y., Du X., Turner N., Brown AJ and Yang H. (2019) Enhanced acyl-CoA: cholesterol acyltransferase activity increases cholesterol levels on lipid droplet surface and impairs adipocyte function. Journal of Biological Chemistry, 294: 19306-19321.

Xu Y., Mak H.Y., Lukmantara I., Li Y.E., Hoehn K.L., Huang X., Du X. and Yang H. (2019) CDP-DAG Synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. Journal of Biological Chemistry, 294, 1-16; doi:10.1074/jbc.RA119.009992


Gao M. and Yang H. (2018) VPS13: A lipid transfer protein making contacts at multiple cellular locations.  Journal of Cell Biology, 217: 3322-3324.  

Yan R., Qian H., Lukmantara I., Gao M., Du, X., Yan N. and Yang H. (2018) Human SEIPIN Binds Anionic Phospholipids. Developmental Cell, 47, 1–9. Highlighted by F1000Prime

Du X, Zadoorian A, Lukmantara I, Qi Y, Brown AJ & Yang H. (2018) Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. Journal of Biological Chemistry, 293: 3806-3818.

Du X, Turner N & Yang H. (2018) The role of oxysterol binding proteins in cancer. Seminars in Cell and Developmental Biology, 81: 149-153.

Ghai R, Du X, Wang H, Dong J, Ferguson C, Brown AJ, Parton RG, Wu JW & Yang H. (2017)  ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P2) and regulate its level at the plasma membrane. Nature Communications, 8:757. Highlighted by F1000Prime

Qi Y, Kapterian TS, Du X, Ma Q, Fei W, Zhang Y, Huang X, Dawes IW & Yang H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57:767-80.

Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA & Yang H. (2016) SEIPIN regulates lipid droplet expansion and adipocyte development through modulating the activity of glycerol-3-phosphate acyltransferase. Cell Reports, 17: 1546–1559.

Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL & Song BL. (2015) Cholesterol transport through a lysosome-peroxisome membrane contact. CELL, 161: 291-306.

Du X, Brown AJ & Yang H. (2015). Novel mechanisms of intracellular cholesterol transport: membrane contact sites and oxysterol binding proteins. Current Opinion in Cell Biology, 35; 37-42.

Liu L, Jiang QQ, Wang, X, Zhang Y, Lin RC, Lan S, Shui, G, Zhou L, Li P, Wang Y, Cui X, Gao MM, Zhang L, Lv Y, Xu G, Liu G, Zhao D & Yang H. (2014) Adipose-specific knockout of seipin/BSCL2 results in progressive lipodystrophy. Diabetes, 63:1–12 doi 10.2337/db13-0729

Du X, Kazim AS, Dawes IW, Brown AJ & Yang H. (2013) The AAA ATPase VPS4/SKD1 Regulates Endosomal Cholesterol Trafficking Independently of ESCRT-III. Traffic, 14: 107-19.

Yang H*, Galea A, Sytnyk V & Crossley M. (2012) Controlling the size of lipid droplets: protein and lipid factors. Current Opinion in Cell Biology, 24:509-16. (* corresponding author)

Cui X, Wang Y, Meng L, Fei W, Deng J, Xu G, Peng X, Ju S, Liu G, Zhao L & Yang H. (2012) Overexpression of a short isoform of human seipin/BSCL2 in mouse adipose tissue results in mild lipodystrophy. Am J Physiol Endocrinol Metab, 302: E705-13.

Du X, Kazim A, Brown AJ & Yang H. (2012) An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Cell Reports, 1: 29-35. (Inaugural Issue)

Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC & Yang H. (2011) 
A role for phosphatidic acid in the formation of “supersized” lipid droplets. PLoS Genetics, 7: e1002201. Highlighted by F1000Prime

Cui X, Wang Y, Tang Y, Liu Y, Zhao L, Deng J, Xu G, Peng X, Ju S, Liu, G & Yang H. (2011) Seipin ablation in mice results in severe generalized lipodystrophy. Human Molecular Genetics, 20: 3022-30

Fei W, Du X & Yang H. (2011) Seipin, adipogenesis and lipid droplets. Trends in Endocrinology and Metabolism, 22: 204-10.

Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ & Yang H. (2011) A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. Journal of Cell Biology, 192: 121-135.

Fei W, Wang H, Fu X, Bielby C & Yang H. (2009) Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae. Biochemical Journal 424:61-7.

Low CP, Shui GH, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR & Yang H. (2008) Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast. Journal of Cell Science, 121:  2671-2684. Editorial highlight by JCS

Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG & Yang H. (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. Journal of Cell Biology, 180: 473-482. Highlighted by BioCentury Science Business Xchange

Yang H. (2006) Nonvesicular sterol transport: two protein families and a sterol sensor? Trends Cell Biol. 16: 427-32. Epub 2006 Jul 28.

Wang P, Zhang Y, Li H, Chieu HK, Munn AL & Yang H. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism. EMBO Journal, 24: 2989-99

Zhang Q, Chieu HK, Low CP, Zhang S, Heng CK & Yang H. (2003) Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. Journal of Biological Chemistry, 278: 47145-55

Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl T, Rothstein R & Sturley SL. (1996) Sterol Esterification in Yeast: A two gene process. Science, 272, 1353-1356.

 
Phone
(+61 2) 9385 8133
E-mail
H.Rob.Yang@unsw.edu.au
Location
Room: 3104, Building E26
  • Books | 2013
    , 2013, Lipid Droplets, Yang H; Li P, (ed.), ELSEVIER ACADEMIC PRESS INC, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329254900017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Books | 2013
    Yang H; Li P, 2013, Preface, http://dx.doi.org/10.1016/B978-0-12-408051-5.10000-2
  • Book Chapters | 2021
    Yang H; Liu J, 2021, 'Structure and function of lipid droplets', in Biochemistry of Lipids, Lipoproteins and Membranes, Elsevier, pp. 357 - 394, http://dx.doi.org/10.1016/b978-0-12-824048-9.00006-7
    Book Chapters | 2005
    Yang H, 2005, 'Metabolism of storage neutral lipids in yeast', in Daum G (ed.), Cell Biology and Dynamics of Yeast Lipids, Research Signpost, pp. 219 - 246
  • Journal articles | 2024
    Coates HW; Nguyen TB; Du X; Olzomer EM; Farrell R; Byrne FL; Yang H; Brown AJ, 2024, 'The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues', Journal of Biological Chemistry, 300, http://dx.doi.org/10.1016/j.jbc.2024.107232
    Journal articles | 2024
    Li YE; Norris DM; Xiao FN; Pandzic E; Whan RM; Fok S; Zhou M; Du G; Liu Y; Du X; Yang H, 2024, 'Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202307041
    Journal articles | 2024
    Liu Y; Yang H, 2024, 'WIPI4 loss linked to ferroptosis', Nature Cell Biology, 26, pp. 506 - 507, http://dx.doi.org/10.1038/s41556-024-01359-1
    Journal articles | 2024
    Peng K; Chen X; Pei K; Wang X; Ma X; Liang C; Dong Q; Liu Z; Han M; Liu G; Yang H; Zheng M; Liu G; Gao M, 2024, 'Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr−/− mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2023.166850
    Journal articles | 2023
    Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', eLife, 12, http://dx.doi.org/10.7554/eLife.82843
    Journal articles | 2023
    Lin Y; Ran L; Du X; Yang H; Wu Y, 2023, 'Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2023.159365
    Journal articles | 2023
    Norris D; Aw Y; Yang H, 2023, 'Nonvesicular trafficking of cholesterol by Aster proteins', Life Metabolism, 2, http://dx.doi.org/10.1093/lifemeta/load003
    Journal articles | 2023
    Tao B; Yang H; Fan R, 2023, 'Seeing the Action of Lipid Droplets in Aging and Longevity', GEN Biotechnology, 2, pp. 287 - 289, http://dx.doi.org/10.1089/genbio.2023.29106.bta
    Journal articles | 2023
    Zadoorian A; Du X; Yang H, 2023, 'Lipid droplet biogenesis and functions in health and disease', Nature Reviews Endocrinology, 19, pp. 443 - 459, http://dx.doi.org/10.1038/s41574-023-00845-0
    Journal articles | 2022
    Keable R; Hu S; Pfundstein G; Kozlova I; Su F; Du X; Yang H; Gunnersen J; Schachner M; Leshchyns’ka I; Sytnyk V, 2022, 'The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes', Cellular and Molecular Life Sciences, 79, http://dx.doi.org/10.1007/s00018-022-04575-w
    Journal articles | 2022
    Liang C; Wang X; Peng K; Lai P; Liu Z; Ma J; Chen X; Liu G; Zheng M; Wang Y; Yang H; Liu G; Xian X; Gao M, 2022, 'Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia', Oxidative Medicine and Cellular Longevity, 2022, http://dx.doi.org/10.1155/2022/1889632
    Journal articles | 2022
    Lukmantara I; Chen F; Mak HY; Zadoorian A; Du X; Xiao FN; MacMurray Norris D; Pandzic E; Whan R; Zhong Q; Yang H, 2022, 'PI(3)P and DFCP1 regulate the biogenesis of lipid droplets', Molecular Biology of the Cell, 33, http://dx.doi.org/10.1091/mbc.E22-07-0279
    Journal articles | 2022
    Tang G; Ma C; Li L; Zhang S; Li F; Wu J; Yin Y; Zhu Q; Liang Y; Wang R; Huang H; Zhao TJ; Yang H; Li P; Chen FJ, 2022, 'PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure', Science China Life Sciences, 65, pp. 2287 - 2300, http://dx.doi.org/10.1007/s11427-022-2157-y
    Journal articles | 2022
    Xu J; Chen S; Wang W; Man Lam S; Xu Y; Zhang S; Pan H; Liang J; Huang X; Wang Y; Li T; Jiang Y; Wang Y; Ding M; Shui G; Yang H; Huang X, 2022, 'Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis', Science Bulletin, 67, pp. 299 - 314, http://dx.doi.org/10.1016/j.scib.2021.10.014
    Journal articles | 2022
    Ye JY; Huang AJ; Fu ZZ; Gong YY; Yang HY; Zhou HW, 2022, 'A study of congenital generalized lipodystrophy (CGL) caused by BSCL2 gene mutation', Yi chuan = Hereditas, 44, pp. 926 - 936, http://dx.doi.org/10.16288/j.yczz.22-222
    Journal articles | 2021
    Chu BB; Liao YC; Qi W; Xie C; Du X; Wang J; Yang H; Miao HH; Li BL; Song BL, 2021, 'Erratum: Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (2015) 161(2) (291–306), (S0092867415001853), (10.1016/j.cell.2015.02.019))', Cell, 184, pp. 289, http://dx.doi.org/10.1016/j.cell.2020.12.023
    Journal articles | 2021
    Du X; Yang H, 2021, 'Seipin regulates the formation of nuclear lipid droplets from a distance', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/JCB.202011166
    Journal articles | 2021
    Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105
    Journal articles | 2021
    Mak HY; Ouyang Q; Tumanov S; Xu J; Rong P; Dong F; Lam SM; Wang X; Lukmantara I; Du X; Gao M; Brown AJ; Gong X; Shui G; Stocker R; Huang X; Chen S; Yang H, 2021, 'AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27279-4
    Journal articles | 2021
    Molenaar MR; Yadav KK; Toulmay A; Wassenaar TA; Mari MC; Caillon L; Chorlay A; Lukmantara IE; Haaker MW; Wubbolts RW; Houweling M; Vaandrager AB; Prieur X; Reggiori F; Choudhary V; Yang H; Schneiter R; Thiam AR; Prinz WA; Helms JB, 2021, 'Retinyl esters form lipid droplets independently of triacylglycerol and seipin', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202011071
    Journal articles | 2021
    Xiang J; Zhang S; Xu R; Chu H; Biswas S; Yu S; Miao D; Li W; Li S; Brown AJ; Yang H; Xu Y; Li B; Liu H, 2021, 'Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202001945R
    Journal articles | 2021
    Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, pp. 1012 - +, http://dx.doi.org/10.1126/science.abb2224
    Journal articles | 2021
    Zhang T; Li YE; Yuan Y; Du X; Wang Y; Dong X; Yang H; Qi S, 2021, 'TMEM41B and VMP1 are phospholipid scramblases', Autophagy, 17, pp. 2048 - 2050, http://dx.doi.org/10.1080/15548627.2021.1937898
    Journal articles | 2021
    Zoni V; Khaddaj R; Lukmantara I; Shinoda W; Yang H; Schneiter R; Vanni S, 2021, 'Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2017205118
    Journal articles | 2020
    Aw YC; Brown AJ; Wu JW; Yang H, 2020, 'ORP1L, ORP1S, and ORP2: Lipid Sensors and Transporters', Contact, 3, http://dx.doi.org/10.1177/2515256420956818
    Journal articles | 2020
    Dou YQ; Kong P; Li CL; Sun HX; Li WW; Yu Y; Nie L; Zhao LL; Miao SB; Li XK; Dong C; Zhang JW; Liu Y; Huo XX; Chi K; Gao X; Zhang N; Weng L; Yang H; Zhang F; Han M, 2020, 'Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia', Theranostics, 10, pp. 1197 - 1212, http://dx.doi.org/10.7150/thno.39320
    Journal articles | 2020
    Du X; Yang H, 2020, 'Triacylglycerol Measurement in HeLa Cells', Bio-protocol, 10, http://dx.doi.org/10.21769/BioProtoc.3852
    Journal articles | 2020
    Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162
    Journal articles | 2020
    Gao M; Liu L; Wang X; Mak HY; Liu G; Yang H, 2020, 'GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy', Human Molecular Genetics, 29, pp. 432 - 443, http://dx.doi.org/10.1093/hmg/ddz300
    Journal articles | 2020
    Gao M; Yang C; Wang X; Guo M; Yang L; Gao S; Zhang X; Ruan G; Li X; Tian W; Lu G; Dong X; Ma S; Li W; Wang Y; Zhu H; He J; Yang H; Liu G; Xian X, 2020, 'ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death', Metabolism: Clinical and Experimental, 109, http://dx.doi.org/10.1016/j.metabol.2020.154296
    Journal articles | 2020
    Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Gao M; Liao J, 2020, 'Erratum: Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet (Scientific reports (2019) 9 1 (17848))', Scientific reports, 10, pp. 2181, http://dx.doi.org/10.1038/s41598-020-58201-5
    Journal articles | 2020
    Luo J; Yang H; Song BL, 2020, 'Mechanisms and regulation of cholesterol homeostasis', Nature Reviews Molecular Cell Biology, 21, pp. 225 - 245, http://dx.doi.org/10.1038/s41580-019-0190-7
    Journal articles | 2020
    Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell
    Journal articles | 2020
    Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338
    Journal articles | 2020
    Zhao M; Zhao L; Xiong X; He Y; Huang W; Liu Z; Ji L; Pan B; Guo X; Wang L; Cheng S; Xu M; Yang H; Yin Y; Garcia-Barrio MT; Chen YE; Meng X; Zheng L, 2020, 'TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice', Gastroenterology, 158, pp. 2266 - 2281.e27, http://dx.doi.org/10.1053/j.gastro.2020.02.033
    Journal articles | 2019
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    Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017
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    Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558
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    Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136
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    Wang Q; Ting WL; Yang H; Wong PT, 2005, 'High doses of simavastatin upregulate dopamine D(1) and D(2) receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase', British Journal of Pharmacology, 144, pp. 933 - 939
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    Woo WH; Yang H; Wong KP; Halliwell B, 2003, 'Sulphite oxidase gene expression in human brain and in other human and rat tissues', Biochemical and Biophysical Research Communications, 305, pp. 619 - 623
    Journal articles | 2003
    Yeo SC; Xu LL; Ren J; Boulton VJ; Wagle MD; Liu CF; Ren G; Wong P; Zahn DR; Sasajala P; Yang H; Piper RD; Munn AL, 2003, 'Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae', Journal of Cell Science, 116, pp. 3957 - 3970
    Journal articles | 2003
    Zhang Q; Chieu HK; Low C; Zhang SP; Heng CK; Yang H, 2003, 'Schizosaccharomyces pombe cells deficient in Triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase', The Journal of Biological Chemistry, 278, pp. 47145 - 47155
    Journal articles | 2001
    Li T; Duan W; Yang H; Lee MK; Bte Mustafa F; Lee BH; Teo TS, 2001, 'Identification of two proteins, S14 and UIP1, that interact with UCH37', FEBS Letters, 488, pp. 201 - 205, http://dx.doi.org/10.1016/S0014-5793(00)02436-4
    Journal articles | 2000
    Li T; Naqvi NI; Yang H; Teo TS, 2000, 'Identification of a 26S proteasome-associated UCH in fission yeast', Biochemical and Biophysical Research Communications, 272, pp. 270 - 275, http://dx.doi.org/10.1006/bbrc.2000.2767
    Journal articles | 1998
    Liang JS; Wu X; Jiang H; Zhou M; Yang H; Angkeow P; Huang LS; Sturley SL; Ginsberg H, 1998, 'Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of β sheet domains', Journal of Biological Chemistry, 273, pp. 35216 - 35221, http://dx.doi.org/10.1074/jbc.273.52.35216
    Journal articles | 1997
    Yang H; Cromley D; Wang H; Billheimer JT; Sturley SL, 1997, 'Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity', Journal of Biological Chemistry, 272, pp. 3980 - 3985, http://dx.doi.org/10.1074/jbc.272.7.3980
    Journal articles | 1996
    Arthington-Skaggs BA; Crowell DN; Yang H; Sturley SL; Bard M, 1996, 'Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway', FEBS Letters, 392, pp. 161 - 165, http://dx.doi.org/10.1016/0014-5793(96)00807-1
    Journal articles | 1996
    Yang H; Bard M; Bruner DA; Gleeson A; Deckelbaum RJ; Aljinovic G; Pohl TM; Rothstein R; Sturley SL, 1996, 'Sterol esterification in yeast: A two-gene process', Science, 272, pp. 1353 - 1356, http://dx.doi.org/10.1126/science.272.5266.1353
    Journal articles | 1995
    Piper RC; Cooper AA; Yang H; Stevens TH, 1995, 'VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae', Journal of Cell Biology, 131, pp. 603 - 617, http://dx.doi.org/10.1083/jcb.131.3.603
    Journal articles |
    Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, 47, pp. 248 - 256
  • Preprints | 2024
    Wu J; Gao M; Wu X; Liu Y; Du X; Liang Y; Ma C; Li P; Chen F-J; Yang H, 2024, PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis, http://dx.doi.org/10.1101/2024.08.22.609036
    Preprints | 2022
    Amanda Tan RP; Kozlova I; Su F; Sah S; Keable R; Hagan W; Bustamante S; Du X; Osborne B; Turner N; Clemens K; Begg D; Phelps E; Yang H; Leshchyns’ka I; Sytnyk V, 2022, Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65), http://dx.doi.org/10.1101/2022.02.08.479601
    Preprints | 2022
    Coates H; Olzomer E; Du X; Farrell R; Yang H; Byrne F; Brown A, 2022, Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase, http://dx.doi.org/10.1101/2022.08.18.504470

My Research Supervision

In 2021, there will be two Ph.D. students and three honors students