Dr Hugh Goold

Dr Hugh Goold

Lecturer
Science
School of Biotech & Biomolecular Science

Dr Hugh Goold is a Scientia Lecturer in synthetic biology at UNSW Sydney, working in partnership with NSW DPIRD Agriculture and Biosecurity. His research focuses on synthetic genomics and the engineering of yeast, microbial and algal systems to address challenges in agriculture, biotechnology and environmental resilience. He led the construction and debugging of SynXVI, the 903-kb synthetic chromosome XVI of the international Sc2.0 Synthetic Yeast Genome Project, work published in Nature Communications, and has contributed to broader efforts to understand the principles of engineering genomes at chromosome scale. 

Hugh is currently leading The Golden Genome Project, funded by Revive & Restore, which applies genetic engineering and genome-scale approaches to microalgae to investigate and engineer traits associated with climate resilience.

His research spans synthetic genomics, algal biotechnology and agricultural biotechnology, and his work has been published in Nature Biotechnology, Nature Communications and Cell Genomics. His UNSW Scientia appointment continues a longstanding research partnership with NSW DPIRD, linking academic synthetic biology with agricultural and biosecurity research. 

Hugh completed a cotutelle PhD through the University of Sydney and Aix-Marseille University, conducting his research at CEA Cadarache in the Laboratoire de Bioénergétique et Biotechnologie des Bactéries et Microalgues in France. His research and scientific commentary have attracted substantial public interest, with appearances and coverage including NBN News, Good Weekend and The Sydney Morning Herald, alongside science and technology media. He sits on the executive committee of the Australian French Association for Research and Innovation, and acts as the NSW hub leader.

He is an active science communicator and advocate for translating advances in synthetic biology into practical applications.

  • Journal articles | 2026
    Berry O; Nitschke MR; Zivaljevic A; Budd AM; Zaiko A; Camp EF; Raes EJ; Luter HM; Goold HD; van de Kamp J; Seymour JR; Quigley KM; West KM; Takahashi M; Paul NA; Buerger P; Jarman S; Uthicke S; Chan WY; Yeoh YK, 2026, 'Omics, synthetic biology and biotechnology in Australian marine science', Australian Journal of Maritime and Ocean Affairs, http://dx.doi.org/10.1080/18366503.2026.2694228
    Journal articles | 2026
    Collier TRV; da Roza PA; Goold HD; Singh S; Paulsen IT; Walker RSK; Pretorius IS, 2026, 'Microbial lipids for a sustainable future: the growing potential of synthetic microbial engineering for consumer oils', Critical Reviews in Biotechnology, 46, pp. 477 - 500, http://dx.doi.org/10.1080/07388551.2026.2615047
    Journal articles | 2026
    Gargiulo JI; Llorente B; Fabian B; Wlodarczyk A; Goold HD; Paulsen IT; Garcia SC, 2026, 'Invited review: Turning dairy food waste into valuable products via yeast bioproduction', Journal of Dairy Science, 109, pp. 6691 - 6710, http://dx.doi.org/10.3168/jds.2025-27900
    Journal articles | 2025
    Erpf PE; Meier F; Walker RSK; Goold HD; Boeke JD; Paulsen IT; Pretorius IS, 2025, 'Building synthetic chromosomes one yeast at a time: insights from Sc2.0', Nature Biotechnology, 43, pp. 1911 - 1918, http://dx.doi.org/10.1038/s41587-025-02913-4
    Journal articles | 2025
    Goold H, 2025, 'Synthesising success', Biologist, 72, pp. 30 - 33
    Journal articles | 2025
    Goold HD; Kroukamp H; Erpf PE; Zhao Y; Kelso P; Calame J; Timmins JJB; Wightman ELI; Peng K; Carpenter AC; Llorente B; Hawthorne C; Clay S; van Wyk N; Daniel EL; Harrison F; Meier F; Willows RD; Cai Y; Walker RSK; Xu X; Espinosa MI; Stracquadanio G; Bader JS; Mitchell LA; Boeke JD; Williams TC; Paulsen IT; Pretorius IS, 2025, 'Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-024-55318-3
    Journal articles | 2025
    Goold HD, 2025, 'Large molecular weight DNA synthesis to combat invasive risks to Australia', Microbiology Australia, 46, pp. 224 - 226, http://dx.doi.org/10.1071/MA25063
    Journal articles | 2025
    Raman H; Bai Z; McVittie B; Mukherjee S; Goold HD; Zhang Y; Khin NC; Qiu Y; Shamaya N; Liu S; Delourme R; Pogson BJ; Balasubramanian S; Raman R, 2025, 'Genome-Wide Association Study Elucidates the Genetic Architecture of Manganese Tolerance in Brassica napus', Plant Cell and Environment, http://dx.doi.org/10.1111/pce.15433
    Journal articles | 2025
    da Roza PA; Collier TR; Goold HD; Tetu SG; Paulsen IT, 2025, 'Photophysiological and transcriptomic response to the broad-spectrum herbicides atrazine and glyphosate in a photosynthetic picoeukaryote', Microbial Genomics, 11, http://dx.doi.org/10.1099/mgen.0.001402
    Journal articles | 2024
    Goold HD; Moseley JL; Lauersen KJ, 2024, 'The synthetic future of algal genomes', Cell Genomics, 4, http://dx.doi.org/10.1016/j.xgen.2024.100505
    Journal articles | 2024
    da Roza PA; Muller H; Sullivan GJ; Walker RSK; Goold HD; Willows RD; Palenik B; Paulsen IT, 2024, 'Chromosome-scale assembly of the streamlined picoeukaryote Picochlorum sp. SENEW3 genome reveals Rabl-like chromatin structure and potential for C4 photosynthesis', Microbial Genomics, 10, http://dx.doi.org/10.1099/mgen.0.001223
    Journal articles | 2023
    Williams TC; Kroukamp H; Xu X; Wightman ELI; Llorente B; Borneman AR; Carpenter AC; Van Wyk N; Meier F; Collier TRV; Espinosa MI; Daniel EL; Walker RSK; Cai Y; Nevalainen HKM; Curach NC; Deveson IW; Mercer TR; Johnson DL; Mitchell LA; Bader JS; Stracquadanio G; Boeke JD; Goold HD; Pretorius IS; Paulsen IT, 2023, 'Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects', Cell Genomics, 3, http://dx.doi.org/10.1016/j.xgen.2023.100379
    Journal articles | 2022
    , 2022, 'Corrigendum', Journal of Phycology, 58, pp. 182 - 182, http://dx.doi.org/10.1111/jpy.13228
    Journal articles | 2022
    Kutyna DR; Onetto CA; Williams TC; Goold HD; Paulsen IT; Pretorius IS; Johnson DL; Borneman AR, 2022, 'Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-31305-4
    Journal articles | 2022
    Llorente B; Williams TC; Goold HD; Pretorius IS; Paulsen IT, 2022, 'Harnessing bioengineered microbes as a versatile platform for space nutrition', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-33974-7
    Journal articles | 2022
    da Roza PA; Goold HD; Paulsen IT, 2022, 'Picochlorum sp. SENEW3', Trends in Genetics, 38, pp. 209 - 210, http://dx.doi.org/10.1016/j.tig.2021.09.012
    Journal articles | 2020
    Coleman MA; Wood G; Filbee-Dexter K; Minne AJP; Goold HD; Vergés A; Marzinelli EM; Steinberg PD; Wernberg T, 2020, 'Restore or Redefine: Future Trajectories for Restoration', Frontiers in Marine Science, 7, pp. 237, http://dx.doi.org/10.3389/fmars.2020.00237
    Journal articles | 2019
    Coleman MA; Goold HD, 2019, 'Harnessing synthetic biology for kelp forest conservation1', Journal of Phycology, 55, pp. 745 - 751, http://dx.doi.org/10.1111/jpy.12888
    Journal articles | 2019
    Yichie Y; Hasan MT; Tobias PA; Pascovici D; Goold HD; Van Sluyter SC; Roberts TH; Atwell BJ, 2019, 'Salt-Treated Roots of Oryza australiensis Seedlings are Enriched with Proteins Involved in Energetics and Transport', Proteomics, 19, http://dx.doi.org/10.1002/pmic.201900175
    Journal articles | 2018
    Goold HD; Wright P; Hailstones D, 2018, 'Emerging opportunities for synthetic biology in agriculture', Genes, 9, http://dx.doi.org/10.3390/genes9070341
    Journal articles | 2018
    Llorente B; Williams TC; Goold HD, 2018, 'The multiplanetary future of plant synthetic biology', Genes, 9, http://dx.doi.org/10.3390/genes9070348
    Journal articles | 2017
    Goold HD; Kroukamp H; Williams TC; Paulsen IT; Varela C; Pretorius IS, 2017, 'Yeast's balancing act between ethanol and glycerol production in low-alcohol wines', Microbial Biotechnology, 10, pp. 264 - 278, http://dx.doi.org/10.1111/1751-7915.12488
    Journal articles | 2016
    Goold HD; Cuiné S; Légeret B; Liang Y; Brugière S; Auroy P; Javot H; Tardif M; Jones B; Beisson F; Peltier G; Li-Beisson Y, 2016, 'Saturating light induces sustained accumulation of oil in plastidal lipid droplets in Chlamydomonas reinhardtii', Plant Physiology, 171, pp. 2406 - 2417, http://dx.doi.org/10.1104/pp.16.00718
    Journal articles | 2016
    Goold HD; Nguyen HM; Kong F; Beyly-Adriano A; Légeret B; Billon E; Cuiné S; Beisson F; Peltier G; Li-Beisson Y, 2016, 'Whole Genome Re-Sequencing Identifies a Quantitative Trait Locus Repressing Carbon Reserve Accumulation during Optimal Growth in Chlamydomonas reinhardtii', Scientific Reports, 6, http://dx.doi.org/10.1038/srep25209
    Journal articles | 2015
    Goold H; Beisson F; Peltier G; Li-Beisson Y, 2015, 'Microalgal lipid droplets: composition, diversity, biogenesis and functions', Plant Cell Reports, 34, pp. 545 - 555, http://dx.doi.org/10.1007/s00299-014-1711-7
    Journal articles | 2011
    Bennett CL; Fallah-Arani F; Conlan T; Trouillet C; Goold H; Chorro L; Flutter B; Means TK; Geissmann F; Chakraverty R, 2011, 'Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin', Blood, 117, pp. 7063 - 7069, http://dx.doi.org/10.1182/blood-2011-01-329185
    Journal articles | 2011
    Fernandes E; Goold HD; Kissenpfennig A; Malissen B; Dyson J; Bennett CL, 2011, 'The role of direct presentation by donor dendritic cells in rejection of minor histocompatibility antigen-mismatched skin and hematopoietic cell grafts', Transplantation, 91, pp. 154 - 160, http://dx.doi.org/10.1097/TP.0b013e318201ac27
    Journal articles | 2011
    Goold HD; Escors D; Conlan TJ; Chakraverty R; Bennett CL, 2011, 'Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors', Journal of Immunology, 186, pp. 4565 - 4572, http://dx.doi.org/10.4049/jimmunol.1002529
    Journal articles | 2010
    , 2010, 'Abstracts of EBMT (European Group for Blood and Bone Marrow Transplantation) 2010. March 21-14, 2010. Vienna, Austria.', Bone Marrow Transplantation, 45 Suppl 2, pp. S1 - 427
    Journal articles | 2008
    , 2008, 'Abstracts from the Annual Congress of the British Society for Immunology. November 17-21, 2008. Glasgow, United Kingdom.', Immunology, 125 Suppl 1, pp. 1 - 144
  • Conference Papers | 2010
    Fallah-Arani F; Goold H; Flutter BR; Sivakumaran J; Bennett CL; Chakraverty R, 2010, 'Distinct temporal and spatial roles for host conventional and Langerhans cells in the development of graft-versus-host injury', in BONE MARROW TRANSPLANTATION, NATURE PUBLISHING GROUP, AUSTRIA, Vienna, pp. S15 - S15, presented at 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, AUSTRIA, Vienna, 21 March 2010 - 24 March 2010
    Conference Papers | 2008
    Goold H; Escors D; Chakraverty R; Bennett CL, 2008, 'Investigation of the requirement for skin DC in the activation of lentiviral vaccination responses', in IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC, SCOTLAND, Glasgow, pp. 53 - 53, presented at Annual Congress of the British-Society-of-Immunology, SCOTLAND, Glasgow, 17 November 2008 - 21 November 2008
    Preprints |
    Raman H; Bai Z; McVittie B; Mukherjee S; Goold HD; Zhang Y; Khin NC; Qiu Y; Liu S; Delourme R; Pogson B; Balasubramanian S; Raman R, Genome-wide association study elucidates the genetic architecture of manganese tolerance in Brassica napus, http://dx.doi.org/10.1101/2024.03.27.586972
    Preprints |
    Williams TC; Kroukamp H; Xu X; Wightman ELI; Llorente B; Borneman AR; Carpenter AC; Van Wyk N; Espinosa MI; Daniel EL; Walker RSK; Cai Y; Nevalainen HKM; Curach NC; Deveson IW; Mercer TR; Johnson DL; Mitchell LA; Bader JS; Stracquadanio G; Boeke JD; Goold HD; Pretorius IS; Paulsen IT, Laboratory evolution and polyploid SCRaMbLE reveal genomic plasticity to synthetic chromosome defects and rearrangements, http://dx.doi.org/10.1101/2022.07.22.501046