Dr Inken Martin (Huttner)

Dr Inken Martin (Huttner)

Conjoint Senior Lecturer
Medicine & Health
School of Clinical Medicine

Dr Inken Martin is a German trained Medical Doctor and Cardiovascular Researcher.  Genetics of Cardiomyopathies and arrhythmias.  Zebrafish models human genetic heart diseases.  Zebrafish echocardiography and ECG.  Genome Engineering.

Level 6 Lowy Packer Building Darlinghurst NSW 2010
  • Journal articles | 2021
    2021, 'Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk', Circulation: Genomic and Precision Medicine, 14, pp. E003144, http://dx.doi.org/10.1161/CIRCGEN.120.003144
    Journal articles | 2021
    2021, 'Mechanisms of TTNtv-related dilated cardiomyopathy: Insights from zebrafish models', Journal of Cardiovascular Development and Disease, 8, pp. 1 - 18, http://dx.doi.org/10.3390/jcdd8020010
    Journal articles | 2019
    2019, 'Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A', npj Regenerative Medicine, 4, http://dx.doi.org/10.1038/s41536-019-0084-5
    Journal articles | 2019
    2019, 'Genetics of atrial cardiomyopathy', Current Opinion in Cardiology, 34, pp. 275 - 281, http://dx.doi.org/10.1097/HCO.0000000000000610
    Journal articles | 2019
    2019, 'Precision Medicine in the Management of Dilated Cardiomyopathy: JACC State-of-the-Art Review', Journal of the American College of Cardiology, 74, pp. 2921 - 2938, http://dx.doi.org/10.1016/j.jacc.2019.10.011
    Journal articles | 2018
    Fatkin D; Cox CD; Huttner IG; Martinac B, 2018, 'Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy?', Heart Lung and Circulation, 27, pp. 1093 - 1098, http://dx.doi.org/10.1016/j.hlc.2018.03.028
    Journal articles | 2018
    Huttner IG; Wang LW; Santiago CF; Horvat C; Johnson R; Cheng D; von Frieling-Salewsky M; Hillcoat K; Bemand TJ; Trivedi G; Braet F; Hesselson D; Alford K; Hayward CS; Seidman JG; Seidman CE; Feneley MP; Linke WA; Fatkin D, 2018, 'A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance', Circulation. Genomic and precision medicine, 11, pp. e002135, http://dx.doi.org/10.1161/CIRCGEN.118.002135
    Journal articles | 2018
    Wang LW; Kesteven SH; Huttner IG; Feneley MP; Fatkin D, 2018, 'High-frequency echocardiography ― transformative clinical and research applications in humans, mice, and zebrafish ―', Circulation Journal, 82, pp. 620 - 628, http://dx.doi.org/10.1253/circj.CJ-18-0027
    Journal articles | 2018
    Zhang H; Dvornikov AV; Huttner IG; Ma X; Santiago CF; Fatkin D; Xu X, 2018, 'A Langendorff-like system to quantify cardiac pump function in adult zebrafish', DMM Disease Models and Mechanisms, 11, http://dx.doi.org/10.1242/dmm.034819
    Journal articles | 2017
    Fatkin D; Huttner IG, 2017, 'Titin-truncating mutations in dilated cardiomyopathy: the long and short of it', Current Opinion in Cardiology, 32, pp. 232 - 238, http://dx.doi.org/10.1097/HCO.0000000000000382
    Journal articles | 2017
    Fatkin D; Santiago CF; Huttner IG; Lubitz SA; Ellinor PT, 2017, 'Genetics of Atrial Fibrillation: State of the Art in 2017', Heart Lung and Circulation, 26, pp. 894 - 901, http://dx.doi.org/10.1016/j.hlc.2017.04.008
    Journal articles | 2017
    Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', JACC: Basic to Translational Science, 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006
    Journal articles | 2017
    Wang LW; Huttner IG; Santiago CF; Kesteven SH; Yu Z-Y; Feneley MP; Fatkin D, 2017, 'Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models', DMM Disease Models and Mechanisms, 10, pp. 63 - 76, http://dx.doi.org/10.1242/dmm.026989
    Journal articles | 2016
    Christensen AH; Chatelain FC; Huttner IG; Olesen MS; Soka M; Feliciangeli S; Horvat C; Santiago CF; Vandenberg JI; Schmitt N; Olesen S-P; Lesage F; Fatkin D, 2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.yjmcc.2016.04.006
    Journal articles | 2013
    Huttner IG; Trivedi G; Jacoby A; Mann SA; Vandenberg JI; Fatkin D, 2013, 'A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death', Journal of Molecular and Cellular Cardiology, 61, pp. 123 - 132, http://dx.doi.org/10.1016/j.yjmcc.2013.06.005
    Journal articles | 2013
    Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, 67, pp. 69 - 76, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014
    Journal articles | 2011
    2011, 'PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling', Molecular and Cellular Biology, 31, pp. 3424 - 3435, http://dx.doi.org/10.1128/MCB.05269-11
    Journal articles | 2010
    2010, 'JunB-CBFβ signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure', Journal of Cell Science, 123, pp. 2613 - 2620, http://dx.doi.org/10.1242/jcs.067967
    Journal articles | 2007
    2007, 'Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)', Journal of Biological Chemistry, 282, pp. 30949 - 30959, http://dx.doi.org/10.1074/jbc.M705499200
    Journal articles | 2006
    2006, 'Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart', Genes and Development, 20, pp. 2361 - 2372, http://dx.doi.org/10.1101/gad.1448306
    Journal articles | 2006
    2006, 'Proof of genetic heterogeneity in X-linked Charcot-Marie-Tooth disease', Neurology, 67, pp. 2016 - 2021, http://dx.doi.org/10.1212/01.wnl.0000247271.40782.b7
    Journal articles | 2000
    2000, 'Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae', Biochemistry, 39, pp. 12149 - 12161, http://dx.doi.org/10.1021/bi0012890
  • Reports | 2016
    Wang LW; Huttner IG; Santiago CF; Fatkin D, 2016, Bradycardia in Zebrafish Heart Failure: A True Physiological Response or Anesthetic-Induced Red Herring?, United States, http://dx.doi.org/10.1089/zeb.2016.1367, https://www.ncbi.nlm.nih.gov/pubmed/27676282

1102 Cardiorespiratory Medicine and Haematology, 0604 Genetics, 0606 Physiology

Biochemistry and Cell Biology, Animal Cell and Molecular Biology, Cardiology including Cardiovascular Diseases

Zebrafish Animal Models

Inherited Diseases (including Gene Therapy), Cardiovascular System and Diseases, Preventive Medicine, Animal models.