Dr Inken Martin (Huttner)

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Dr Inken Martin is a German trained Medical Doctor and Cardiovascular Researcher. Genetics of Cardiomyopathies and arrhythmias. Zebrafish models human genetic heart diseases. Zebrafish echocardiography and ECG. Genome Engineering.

E-mail

i.martin@victorchang.edu.au

Location

Level 6 Lowy Packer Building Darlinghurst NSW 2010

Journal articles | 2023

Huttner IG; Santiago CF; Jacoby A; Cheng D; Trivedi G; Cull S; Cvetkovska J; Chand R; Berger J; Currie PD; Smith KA; Fatkin D, 2023, 'Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish', Journal of Cardiovascular Development and Disease, 10, http://dx.doi.org/10.3390/jcdd10100408

Journal articles | 2022

Santiago CF; Huttner IG; Fatkin D, 2022, 'Titin-related Cardiomyopathy: Is it a Distinct Disease?', Current Cardiology Reports, 24, pp. 1069 - 1075, http://dx.doi.org/10.1007/s11886-022-01726-0

Journal articles | 2021

Pineda S; Nikolova-Krstevski V; Leimena C; Atkinson AJ; Altekoester AK; Cox CD; Jacoby A; Huttner IG; Ju YK; Soka M; Ohanian M; Trivedi G; Kalvakuri S; Birker K; Johnson R; Molenaar P; Kuchar D; Allen DG; Van Helden DF; Harvey RP; Hill AP; Bodmer R; Vogler G; Dobrzynski H; Ocorr K; Fatkin D, 2021, 'Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk', Circulation: Genomic and Precision Medicine, 14, pp. E003144, http://dx.doi.org/10.1161/CIRCGEN.120.003144

Journal articles | 2021

Santiago CF; Huttner IG; Fatkin D, 2021, 'Mechanisms of TTNtv-related dilated cardiomyopathy: Insights from zebrafish models', Journal of Cardiovascular Development and Disease, 8, pp. 1 - 18, http://dx.doi.org/10.3390/jcdd8020010

Journal articles | 2019

Fatkin D; Huttner IG; Johnson R, 2019, 'Genetics of atrial cardiomyopathy', Current Opinion in Cardiology, 34, pp. 275 - 281, http://dx.doi.org/10.1097/HCO.0000000000000610

Journal articles | 2019

Fatkin D; Huttner IG; Kovacic JC; Seidman JG; Seidman CE, 2019, 'Precision Medicine in the Management of Dilated Cardiomyopathy: JACC State-of-the-Art Review', Journal of the American College of Cardiology, 74, pp. 2921 - 2938, http://dx.doi.org/10.1016/j.jacc.2019.10.011

Journal articles | 2019

Hall TE; Wood AJ; Ehrlich O; Li M; Sonntag CS; Cole NJ; Huttner IG; Sztal TE; Currie PD, 2019, 'Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A', npj Regenerative Medicine, 4, http://dx.doi.org/10.1038/s41536-019-0084-5

Journal articles | 2018

Fatkin D; Cox CD; Huttner IG; Martinac B, 2018, 'Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy?', Heart Lung and Circulation, 27, pp. 1093 - 1098, http://dx.doi.org/10.1016/j.hlc.2018.03.028

Journal articles | 2018

Huttner IG; Wang LW; Santiago CF; Horvat C; Johnson R; Cheng D; von Frieling-Salewsky M; Hillcoat K; Bemand TJ; Trivedi G; Braet F; Hesselson D; Alford K; Hayward CS; Seidman JG; Seidman CE; Feneley MP; Linke WA; Fatkin D, 2018, 'A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance', Circulation. Genomic and precision medicine, 11, pp. e002135, http://dx.doi.org/10.1161/CIRCGEN.118.002135

Journal articles | 2018

Wang LW; Kesteven SH; Huttner IG; Feneley MP; Fatkin D, 2018, 'High-frequency echocardiography ― transformative clinical and research applications in humans, mice, and zebrafish ―', Circulation Journal, 82, pp. 620 - 628, http://dx.doi.org/10.1253/circj.CJ-18-0027

Journal articles | 2018

Zhang H; Dvornikov AV; Huttner IG; Ma X; Santiago CF; Fatkin D; Xu X, 2018, 'A Langendorff-like system to quantify cardiac pump function in adult zebrafish', DMM Disease Models and Mechanisms, 11, http://dx.doi.org/10.1242/dmm.034819

Journal articles | 2017

Fatkin D; Huttner IG; Martin I, 2017, 'Titin-truncating mutations in dilated cardiomyopathy: the long and short of it', Current Opinion in Cardiology, http://dx.doi.org/10.1097/HCO.0000000000000382

Journal articles | 2017

Fatkin D; Santiago CF; Huttner IG; Lubitz SA; Ellinor PT, 2017, 'Genetics of Atrial Fibrillation: State of the Art in 2017', Heart Lung and Circulation, 26, pp. 894 - 901, http://dx.doi.org/10.1016/j.hlc.2017.04.008

Journal articles | 2017

Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', JACC: Basic to Translational Science, 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006

Journal articles | 2017

Wang LW; Huttner IG; Santiago CF; Kesteven SH; Yu ZY; Feneley MP; Fatkin D; Martin I, 2017, 'Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models', DMM Disease Models and Mechanisms, 10, pp. 63 - 76, http://dx.doi.org/10.1242/dmm.026989

Journal articles | 2016

Christensen AH; Chatelain FC; Huttner IG; Olesen MS; Soka M; Feliciangeli S; Horvat C; Santiago CF; Vandenberg JI; Schmitt N; Olesen SP; Lesage F; Fatkin D; Martin I, 2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.yjmcc.2016.04.006

Journal articles | 2013

Huttner IG; Trivedi G; Jacoby A; Mann SA; Vandenberg JI; Fatkin D, 2013, 'A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death', Journal of Molecular and Cellular Cardiology, 61, pp. 123 - 132, http://dx.doi.org/10.1016/j.yjmcc.2013.06.005

Journal articles | 2013

Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen SP; Schmitt N; Fatkin D, 2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014

Journal articles | 2011

Meder B; Huttner IG; Sedaghat-Hamedani F; Just S; Dahme T; Frese KS; Vogel B; Köhler D; Kloos W; Rudloff J; Marquart S; Katus HA; Rottbauer W, 2011, 'PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling', Molecular and Cellular Biology, 31, pp. 3424 - 3435, http://dx.doi.org/10.1128/MCB.05269-11

Journal articles | 2010

Meder B; Just S; Vogel B; Rudloff J; Gärtner L; Dahme T; Huttner I; Zankl A; Katus HA; Rottbauer W, 2010, 'JunB-CBFβ signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure', Journal of Cell Science, 123, pp. 2613 - 2620, http://dx.doi.org/10.1242/jcs.067967

Journal articles | 2007

Strahl T; Huttner IG; Lusin JD; Osawa M; King D; Thorner J; Ames JB, 2007, 'Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)', Journal of Biological Chemistry, 282, pp. 30949 - 30959, http://dx.doi.org/10.1074/jbc.M705499200

Journal articles | 2006

Bendig G; Grimmler M; Huttner IG; Wessels G; Dahme T; Just S; Trano N; Katus HA; Fishman MC; Rottbauer W, 2006, 'Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart', Genes and Development, 20, pp. 2361 - 2372, http://dx.doi.org/10.1101/gad.1448306

Journal articles | 2006

Huttner IG; Kennerson ML; Reddel SW; Radovanovic D; Nicholson GA, 2006, 'Proof of genetic heterogeneity in X-linked Charcot-Marie-Tooth disease', Neurology, 67, pp. 2016 - 2021, http://dx.doi.org/10.1212/01.wnl.0000247271.40782.b7

Journal articles | 2003

Huttner IG; Strahl T; Osawa M; King DS; Ames JB; Thorner J, 2003, 'Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1', Journal of Biological Chemistry, 278, pp. 4862 - 4874, http://dx.doi.org/10.1074/jbc.M207920200

Journal articles | 2000

Ames JB; Hendricks KB; Strahl T; Huttner IG; Hamasaki N; Thorner J, 2000, 'Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae', Biochemistry, 39, pp. 12149 - 12161, http://dx.doi.org/10.1021/bi0012890
Reports | 2016

Wang LW; Huttner IG; Santiago CF; Fatkin D; Martin I, 2016, Bradycardia in Zebrafish Heart Failure: A True Physiological Response or Anesthetic-Induced Red Herring?, http://dx.doi.org/10.1089/zeb.2016.1367

1102 Cardiorespiratory Medicine and Haematology, 0604 Genetics, 0606 Physiology

Biochemistry and Cell Biology, Animal Cell and Molecular Biology, Cardiology including Cardiovascular Diseases

Zebrafish Animal Models

Inherited Diseases (including Gene Therapy), Cardiovascular System and Diseases, Preventive Medicine, Animal models.

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