Professor Jake Baum
Head of School

Professor Jake Baum

  • Ph.D. in Infectious & Tropical Diseases. Co-evolution of Genetic Diversity in Malaria and Humans. London School of Hygiene & Tropical Medicine (University of London), UK (1999-2002; awarded 31-08-2002).
  • M.Sc. Human Biology. University of Oxford, Magdalen College, UK (1997-1998).
  • B.A. Hons (M.A. Oxon). Biological Sciences. University of Oxford, St. Catherine’s College, UK (1993-1996).
Medicine & Health
School of Medical Sciences

I am a parasitologist, cell biologist and medical science innovator. Following Bachelors’ and Masters’ degrees at Oxford, and PhD in London (LSHTM, 2002) I moved to the Walter + Eliza Hall Institute in Melbourne, Australia to work on the molecular and cellular biology of the malaria parasite. I started my own independent lab at the WEHI in 2010 (www.baumlab.com). In 2013, I returned to the UK to Imperial College London, and was later appointed Professor of Cell Biology and Infectious Diseases (2017). In 2020 I helped found the Imperial College Institute of Infection, a new Institute charged with representing the entire interdisciplinary research portfolio of infection research across the University. In 2022, I was recruited back to Australia to take up a tenured Professorship and position as Head of School of Medical Sciences at UNSW, Sydney. My lab (www.baumlab.com) has had a diverse range of interests, across cell biology, drug discovery, novel diagnostics, and vaccine technologies, often working together with industry partnerships. I have mentored to completion 13 PhD students, 20+ postdocs and supported >100 researchers through my lab. 5 former lab members are now independent PIs, 1 is a Journal Editor and 2 have started their own spin-out companies. Throughout my career I’ve been passionate about supporting early career researchers advance their careers in science.

Career highlights include:

Phone
+61-2-9065 7439
Location
Level 2 West Wallace Wurth Building (C27) UNSW, Kensington Campus
  • Book Chapters | 2012
    Riglar DT; Baum J, 2012, 'Static and Dynamic Imaging of Erythrocyte Invasion and Early Intra-erythrocytic Development in Plasmodium falciparum', in Methods in Molecular Biology, Humana Press, pp. 269 - 280, http://dx.doi.org/10.1007/978-1-62703-026-7_18
  • Journal articles | 2022
    Bullen HE; Sanders PR; Dans MG; Jonsdottir TK; Riglar DT; Looker O; Palmer CS; Kouskousis B; Charnaud SC; Triglia T; Gabriela M; Parkyn Schneider M; Chan JA; de Koning-Ward TF; Baum J; Kazura JW; Beeson J; Cowman AF; Gilson PR; Crabb BS, 2022, 'The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture', Molecular Microbiology, vol. 117, pp. 1245 - 1262, http://dx.doi.org/10.1111/mmi.14904
    Journal articles | 2022
    Tamaki F; Fisher F; Milne R; Terán FSR; Wiedemar N; Wrobel K; Edwards D; Baumann H; Gilbert IH; Baragana B; Baum J; Wyllie S, 2022, 'High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria', Antimicrobial Agents and Chemotherapy, vol. 66, pp. e0023722, http://dx.doi.org/10.1128/aac.00237-22
    Journal articles | 2022
    Xie SC; Metcalfe RD; Dunn E; Morton CJ; Huang SC; Puhalovich T; Du Y; Wittlin S; Nie S; Luth MR; Ma L; Kim MS; Pasaje CFA; Kumpornsin K; Giannangelo C; Houghton FJ; Churchyard A; Famodimu MT; Barry DC; Gillett DL; Dey S; Kosasih CC; Newman W; Niles JC; Lee MCS; Baum J; Ottilie S; Winzeler EA; Creek DJ; Williamson N; Parker MW; Brand S; Langston SP; Dick LR; Griffin MDW; Gould AE; Tilley L, 2022, 'Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy', Science, vol. 376, pp. 1074 - 1079, http://dx.doi.org/10.1126/science.abn0611
    Journal articles | 2022
    Yahiya S; Jordan S; Smith HX; Gaboriau DCA; Famodimu MT; Dahalan FA; Churchyard A; Ashdown GW; Baum J, 2022, 'Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum', PLoS Pathogens, vol. 18, pp. e1010276, http://dx.doi.org/10.1371/journal.ppat.1010276
    Journal articles | 2022
    de Vries LE; Jansen PAM; Barcelo C; Munro J; Verhoef JMJ; Pasaje CFA; Rubiano K; Striepen J; Abla N; Berning L; Bolscher JM; Demarta-Gatsi C; Henderson RWM; Huijs T; Koolen KMJ; Tumwebaze PK; Yeo T; Aguiar ACC; Angulo-Barturen I; Churchyard A; Baum J; Fernández BC; Fuchs A; Gamo FJ; Guido RVC; Jiménez-Diaz MB; Pereira DB; Rochford R; Roesch C; Sanz LM; Trevitt G; Witkowski B; Wittlin S; Cooper RA; Rosenthal PJ; Sauerwein RW; Schalkwijk J; Hermkens PHH; Bonnert RV; Campo B; Fidock DA; Llinás M; Niles JC; Kooij TWA; Dechering KJ, 2022, 'Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183', Nature Communications, vol. 13, pp. 2158, http://dx.doi.org/10.1038/s41467-022-29688-5
    Journal articles | 2021
    Blight J; Sala KA; Atcheson E; Kramer H; Turabi AE; Real E; Dahalan FA; Bettencourt P; Dickinson-Craig E; Alves E; Salman AM; Janse CJ; Ashcroft FM; Hill AV; Reyes-Sandoval A; Blagborough AM; Baum J, 2021, 'Dissection-independent production of Plasmodium sporozoites from whole mosquitoes', Life Science Alliance, vol. 4, http://dx.doi.org/10.26508/lsa.202101094
    Journal articles | 2021
    Davidson MS; Andradi-Brown C; Yahiya S; Chmielewski J; O'Donnell AJ; Gurung P; Jeninga MD; Prommana P; Andrew DW; Petter M; Uthaipibull C; Boyle MJ; Ashdown GW; Dvorin JD; Reece SE; Wilson DW; Cunningham KA; Ando DM; Dimon M; Baum J, 2021, 'Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks.', Biol Imaging, vol. 1, pp. e2, http://dx.doi.org/10.1017/S2633903X21000015
    Journal articles | 2021
    Ellis KM; Lucantoni L; Chavchich M; Abraham M; De Paoli A; Luth MR; Zeeman AM; Delves MJ; Terán FSR; Straschil U; Baum J; Kocken CHM; Ralph SA; Winzeler EA; Avery VM; Edstein MD; Baell JB; Creek DJ, 2021, 'The novel bis-1,2,4-Triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite', Antimicrobial Agents and Chemotherapy, vol. 65, http://dx.doi.org/10.1128/AAC.00311-21
    Journal articles | 2021
    Haase S; Condron M; Miller D; Cherkaoui D; Jordan S; Gulbis JM; Baum J, 2021, 'Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum', Molecular and Biochemical Parasitology, vol. 243, http://dx.doi.org/10.1016/j.molbiopara.2021.111374
    Journal articles | 2021
    Lawong A; Gahalawat S; Okombo J; Striepen J; Yeo T; Mok S; Deni I; Bridgford JL; Niederstrasser H; Zhou A; Posner B; Wittlin S; Gamo FJ; Crespo B; Churchyard A; Baum J; Mittal N; Winzeler E; Laleu B; Palmer MJ; Charman SA; Fidock DA; Ready JM; Phillips MA, 2021, 'Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum', Journal of Medicinal Chemistry, vol. 64, pp. 2739 - 2761, http://dx.doi.org/10.1021/acs.jmedchem.0c02022
    Journal articles | 2021
    Miguel-Blanco C; Murithi JM; Benavente ED; Angrisano F; Sala KA; van Schalkwyk DA; Vanaerschot M; Schwach F; Fuchter MJ; Billker O; Sutherland CJ; Campino SG; Clark TG; Blagborough AM; Fidock DA; Herreros E; Gamo FJ; Baum J; Delves MJ, 2021, 'The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957', Scientific Reports, vol. 11, http://dx.doi.org/10.1038/s41598-021-81343-z
    Journal articles | 2021
    Najer A; Blight J; Ducker CB; Gasbarri M; Brown JC; Che J; Høgset H; Saunders C; Ojansivu M; Lu Z; Lin Y; Yeow J; Rifaie-Graham O; Potter M; Tonkin R; Penders J; Doutch JJ; Georgiadou A; Barriga HMG; Holme MN; Cunnington AJ; Bugeon L; Dallman MJ; Barclay WS; Stellacci F; Baum J; Stevens MM, 2021, 'Potent Virustatic Polymer-Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo', ACS Central Science, http://dx.doi.org/10.1021/acscentsci.1c01368
    Journal articles | 2021
    Okaniwa M; Shibata A; Ochida A; Akao Y; White KL; Shackleford DM; Duffy S; Lucantoni L; Dey S; Striepen J; Yeo T; Mok S; Aguiar ACC; Sturm A; Crespo B; Sanz LM; Churchyard A; Baum J; Pereira DB; Guido RVC; Dechering KJ; Wittlin S; Uhlemann AC; Fidock DA; Niles JC; Avery VM; Charman SA; Laleu B, 2021, 'Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors', ACS Infectious Diseases, vol. 7, pp. 1680 - 1689, http://dx.doi.org/10.1021/acsinfecdis.1c00020
    Journal articles | 2021
    Real E; Howick VM; Dahalan FA; Witmer K; Cudini J; Andradi-Brown C; Blight J; Davidson MS; Dogga SK; Reid AJ; Baum J; Lawniczak MKN, 2021, 'A single-cell atlas of Plasmodium falciparum transmission through the mosquito', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-23434-z
    Journal articles | 2021
    Robert-Paganin J; Moussaoui D; Robblee JP; Auguin D; Blake TCA; Krementsova E; Baum J; Trybus KM; Houdusse A, 2021, 'Deciphering the Function and the Regulation of Plasmodium falciparum Myosin A', Biophysical Journal, vol. 120, pp. 344a - 344a, http://dx.doi.org/10.1016/j.bpj.2020.11.2143
    Journal articles | 2021
    Varghese S; Rahmani R; Drew DR; Beeson JG; Baum J; Smith BJ; Baell JB, 2021, 'Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity', ChemMedChem, vol. 16, pp. 679 - 693, http://dx.doi.org/10.1002/cmdc.202000399
    Journal articles | 2021
    Witmer K; Dahalan FA; Delves MJ; Yahiya S; Watson OJ; Straschil U; Chiwcharoen D; Sornboon B; Pukrittayakamee S; Pearson RD; Howick VM; Lawniczak MKN; White NJ; Dondorp AM; Okell LC; Chotivanich K; Ruecker A; Baum J, 2021, 'Transmission of artemisinin-resistant malaria parasites to mosquitoes under antimalarial drug pressure', Antimicrobial Agents and Chemotherapy, vol. 65, http://dx.doi.org/10.1128/AAC.00898-20
    Journal articles | 2021
    Xie SC; Metcalfe RD; Mizutani H; Puhalovich T; Hanssen E; Morton CJ; Du Y; Dogovski C; Huang SC; Ciavarri J; Hales P; Griffin RJ; Cohen LH; Chuang BC; Wittlin S; Deni I; Yeo T; Ward KE; Barry DC; Liu B; Gillett DL; Crespo-Fernandez BF; Ottilie S; Mittal N; Churchyard A; Ferguson D; Aguiar ACC; Guido RVC; Baum J; Hanson KK; Winzeler EA; Gamo FJ; Fidock DA; Baud D; Parker MW; Brand S; Dick LR; Griffin MDW; Gould AE; Tilley L, 2021, 'Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, http://dx.doi.org/10.1073/pnas.2107213118
    Journal articles | 2020
    Ashdown GW; Dimon M; Fan M; Terán FSR; Witmer K; Gaboriau DCA; Armstrong Z; Ando DM; Baum J, 2020, 'A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens', Science Advances, vol. 6, http://dx.doi.org/10.1126/sciadv.aba9338
    Journal articles | 2020
    Baum J; Pasvol G; Carter R, 2020, 'The R0 journey: from 1950s malaria to COVID-19', Nature, vol. 582, pp. 488, http://dx.doi.org/10.1038/d41586-020-01882-9
    Journal articles | 2020
    Blake TCA; Haase S; Baum J, 2020, 'Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum', PLoS Pathogens, vol. 16, http://dx.doi.org/10.1371/journal.ppat.1009007
    Journal articles | 2020
    Eagon S; Hammill JT; Sigal M; Ahn KJ; Tryhorn JE; Koch G; Belanger B; Chaplan CA; Loop L; Kashtanova AS; Yniguez K; Lazaro H; Wilkinson SP; Rice AL; Falade MO; Takahashi R; Kim K; Cheung A; Dibernardo C; Kimball JJ; Winzeler EA; Eribez K; Mittal N; Gamo FJ; Crespo B; Churchyard A; García-Barbazán I; Baum J; Anderson MO; Laleu B; Guy RK, 2020, 'Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines', Journal of Medicinal Chemistry, vol. 63, pp. 11902 - 11919, http://dx.doi.org/10.1021/acs.jmedchem.0c01152
    Journal articles | 2020
    Llorà-Batlle O; Michel-Todó L; Witmer K; Toda H; Fernández-Becerra C; Baum J; Cortés A, 2020, 'Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum', Science Advances, vol. 6, http://dx.doi.org/10.1126/sciadv.aaz5057
    Journal articles | 2020
    Moussaoui D; Robblee JP; Auguin D; Krementsova EB; Haase S; Blake TCA; Baum J; Robert-Paganin J; Trybus KM; Houdusse A, 2020, 'Full-length plasmodium falciparum myosin a and essential light chain pfelc structures provide new anti-malarial targets', eLife, vol. 9, pp. 1 - 24, http://dx.doi.org/10.7554/eLife.60581
    Journal articles | 2020
    Qian WW; Xia C; Venugopalan S; Narayanaswamy A; Dimon M; Ashdown GW; Baum J; Peng J; Michael Ando D, 2020, 'Batch equalization with a generative adversarial network', Bioinformatics, vol. 36, pp. I875 - I883, http://dx.doi.org/10.1093/bioinformatics/btaa819
    Journal articles | 2020
    Rueda-Zubiaurre A; Yahiya S; Fischer OJ; Hu X; Saunders CN; Sharma S; Straschil U; Shen J; Tate EW; Delves MJ; Baum J; Barnard A; Fuchter MJ, 2020, 'Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes', Journal of Medicinal Chemistry, vol. 63, pp. 2240 - 2262, http://dx.doi.org/10.1021/acs.jmedchem.9b00898
    Journal articles | 2020
    Saunders CN; Cota E; Baum J; Tate EW, 2020, 'Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex', ACS Chemical Biology, vol. 15, pp. 1313 - 1320, http://dx.doi.org/10.1021/acschembio.0c00328
    Journal articles | 2020
    Wang X; Wilkinson MD; Lin X; Ren R; Willison KR; Ivanov AP; Baum J; Edel JB, 2020, 'Erratum: Single-molecule nanopore sensing of actin dynamics and drug binding (Chemical Science (2020) 11 (970-979) DOI: 10.1039/C9SC05710B)', Chemical Science, vol. 11, pp. 8036 - 8038, http://dx.doi.org/10.1039/d0sc90132f
    Journal articles | 2020
    Wang X; Wilkinson MD; Lin X; Ren R; Willison KR; Ivanov AP; Baum J; Edel JB, 2020, 'Single-molecule nanopore sensing of actin dynamics and drug binding', Chemical Science, vol. 11, pp. 970 - 979, http://dx.doi.org/10.1039/c9sc05710b
    Journal articles | 2020
    Warszawski S; Dekel E; Campeotto I; Marshall JM; Wright KE; Lyth O; Knop O; Regev-Rudzki N; Higgins MK; Draper SJ; Baum J; Fleishman SJ, 2020, 'Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5', Proteins: Structure, Function and Bioinformatics, vol. 88, pp. 187 - 195, http://dx.doi.org/10.1002/prot.25786
    Journal articles | 2020
    Wilkinson MD; Lai HE; Freemont PS; Baum J, 2020, 'A biosynthetic platform for antimalarial drug discovery', Antimicrobial Agents and Chemotherapy, vol. 64, http://dx.doi.org/10.1128/AAC.02129-19
    Journal articles | 2019
    Baragaña B; Forte B; Choi R; Hewitt SN; Bueren-Calabuig JA; Pisco JP; Peet C; Dranow DM; Robinson DA; Jansen C; Norcross NR; Vinayak S; Anderson M; Brooks CF; Cooper CA; Damerow S; Delves M; Dowers K; Duffy J; Edwards TE; Hallyburton I; Horst BG; Hulverson MA; Ferguson L; Jiménez-Díaz MB; Jumani RS; Lorimer DD; Love MS; Maher S; Matthews H; McNamara CW; Miller P; O’Neill S; Ojo KK; Osuna-Cabello M; Pinto E; Post J; Riley J; Rottmann M; Sanz LM; Scullion P; Sharma A; Shepherd SM; Shishikura Y; Simeons FRC; Stebbins EE; Stojanovski L; Straschil U; Tamaki FK; Tamjar J; Torrie LS; Vantaux A; Witkowski B; Wittlin S; Yogavel M; Zuccotto F; Angulo-Barturen I; Sinden R; Baum J; Gamo FJ; Mäser P; Kyle DE; Winzeler EA; Myler PJ; Wyatt PG; Floyd D; Matthews D; Sharma A; Striepen B; Huston CD; Gray DW; Fairlamb AH; Pisliakov AV; Walpole C; Read KD; Van Voorhis WC; Gilbert IH, 2019, 'Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, pp. 7015 - 7020, http://dx.doi.org/10.1073/pnas.1814685116
    Journal articles | 2019
    Del Rosario M; Periz J; Pavlou G; Lyth O; Latorre-Barragan F; Das S; Pall GS; Stortz JF; Lemgruber L; Whitelaw JA; Baum J; Tardieux I; Meissner M, 2019, 'Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion', EMBO Reports, vol. 20, http://dx.doi.org/10.15252/embr.201948896
    Journal articles | 2019
    Knuepfer E; Wright KE; Prajapati SK; Rawlinson TA; Mohring F; Koch M; Lyth OR; Howell SA; Villasis E; Snijders AP; Moon RW; Draper SJ; Rosanas-Urgell A; Higgins MK; Baum J; Holder AA, 2019, 'Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites', PLoS Pathogens, vol. 15, http://dx.doi.org/10.1371/journal.ppat.1007809
    Journal articles | 2019
    Koch M; Cegla J; Jones B; Lu Y; Mallat Z; Blagborough AM; Angrisano F; Baum J, 2019, 'The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection', Malaria Journal, vol. 18, http://dx.doi.org/10.1186/s12936-019-3016-3
    Journal articles | 2019
    Malpartida-Cardenas K; Miscourides N; Rodriguez-Manzano J; Yu LS; Moser N; Baum J; Georgiou P, 2019, 'Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform', Biosensors and Bioelectronics, vol. 145, http://dx.doi.org/10.1016/j.bios.2019.111678
    Journal articles | 2019
    Robert-Paganin J; Robblee JP; Auguin D; Blake TCA; Bookwalter CS; Krementsova EB; Moussaoui D; Previs MJ; Jousset G; Baum J; Trybus KM; Houdusse A, 2019, 'Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-11120-0
    Journal articles | 2019
    Satchwell TJ; Wright KE; Haydn-Smith KL; Sánchez-Román Terán F; Moura PL; Hawksworth J; Frayne J; Toye AM; Baum J, 2019, 'Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-11790-w
    Journal articles | 2019
    Straschil U; Witmer K; Delves MJ; Marks SD; Baum J, 2019, 'Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials', Archives of Disease in Childhood, vol. 104, pp. 1138 - 1142, http://dx.doi.org/10.1136/archdischild-2019-317590
    Journal articles | 2019
    Yahiya S; Rueda-Zubiaurre A; Delves MJ; Fuchter MJ; Baum J, 2019, 'The antimalarial screening landscape—looking beyond the asexual blood stage', Current Opinion in Chemical Biology, vol. 50, pp. 1 - 9, http://dx.doi.org/10.1016/j.cbpa.2019.01.029
    Journal articles | 2018
    Delves MJ; Miguel-Blanco C; Matthews H; Molina I; Ruecker A; Yahiya S; Straschil U; Abraham M; León ML; Fischer OJ; Rueda-Zubiaurre A; Brandt JR; Cortés Á; Barnard A; Fuchter MJ; Calderón F; Winzeler EA; Sinden RE; Herreros E; Gamo FJ; Baum J, 2018, 'A high throughput screen for next-generation leads targeting malaria parasite transmission', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05777-2
    Journal articles | 2018
    Fang H; Gomes AR; Klages N; Pino P; Maco B; Walker EM; Zenonos ZA; Angrisano F; Baum J; Doerig C; Baker DA; Billker O; Brochet M, 2018, 'Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-06733-w
    Journal articles | 2018
    Lubin AS; Rueda-Zubiaurre A; Matthews H; Baumann H; Fisher FR; Morales-Sanfrutos J; Hadavizadeh KS; Nardella F; Tate EW; Baum J; Scherf A; Fuchter MJ, 2018, 'Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum', ACS Infectious Diseases, vol. 4, pp. 523 - 530, http://dx.doi.org/10.1021/acsinfecdis.7b00228
    Journal articles | 2018
    Lyth O; Vizcay-Barrena G; Wright KE; Haase S; Mohring F; Najer A; Henshall IG; Ashdown GW; Bannister LH; Drew DR; Beeson JG; Fleck RA; Moon RW; Wilson DW; Baum J, 2018, 'Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-28457-z
    Journal articles | 2018
    Malpartida-Cardenas K; Rodriguez-Manzano J; Yu LS; Delves MJ; Nguon C; Chotivanich K; Baum J; Georgiou P, 2018, 'Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers', Analytical Chemistry, vol. 90, pp. 11972 - 11980, http://dx.doi.org/10.1021/acs.analchem.8b02416
    Journal articles | 2018
    Witmer K; Sherrard-Smith E; Straschil U; Tunnicliff M; Baum J; Delves M, 2018, 'An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies', Malaria Journal, vol. 17, http://dx.doi.org/10.1186/s12936-018-2436-9
    Journal articles | 2017
    Baum J; Richard D; Riglar DT, 2017, 'Malaria Parasite Invasion: Achieving Superb Resolution', Cell Host and Microbe, vol. 21, pp. 294 - 296, http://dx.doi.org/10.1016/j.chom.2017.02.006
    Journal articles | 2017
    Bookwalter CS; Tay CL; McCrorie R; Previs MJ; Lu H; Krementsova EB; Fagnant PM; Baum J; Trybus KM, 2017, 'Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin', Journal of Biological Chemistry, vol. 292, pp. 19290 - 19303, http://dx.doi.org/10.1074/jbc.M117.813972
    Journal articles | 2017
    Das S; Lemgruber L; Tay CL; Baum J; Meissner M, 2017, 'Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development', BMC Biology, vol. 15, http://dx.doi.org/10.1186/s12915-017-0406-2
    Journal articles | 2017
    Koch M; Wright KE; Otto O; Herbig M; Salinas ND; Tolia NH; Satchwell TJ; Guck J; Brooks NJ; Baum J, 2017, 'Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. 4225 - 4230, http://dx.doi.org/10.1073/pnas.1620843114
    Journal articles | 2017
    Miguel-Blanco C; Molina I; Bardera AI; Díaz B; De Las Heras L; Lozano S; González C; Rodrigues J; Delves MJ; Ruecker A; Colmenarejo G; Viera S; Martínez-Martínez MS; Fernández E; Baum J; Sinden RE; Herreros E, 2017, 'Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms15160
    Journal articles | 2017
    Wong W; Bai XC; Sleebs BE; Triglia T; Brown A; Thompson JK; Jackson KE; Hanssen E; Marapana DS; Fernandez IS; Ralph SA; Cowman AF; Scheres SHW; Baum J, 2017, 'Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis', Nature Microbiology, vol. 2, http://dx.doi.org/10.1038/nmicrobiol.2017.31
    Journal articles | 2016
    Bane KS; Lepper S; Kehrer J; Sattler JM; Singer M; Reinig M; Klug D; Heiss K; Baum J; Mueller AK; Frischknecht F, 2016, 'The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites', PLoS Pathogens, vol. 12, http://dx.doi.org/10.1371/journal.ppat.1005710
    Journal articles | 2016
    Bargieri DY; Thiberge S; Tay CL; Carey AF; Rantz A; Hischen F; Lorthiois A; Straschil U; Singh P; Singh S; Triglia T; Tsuboi T; Cowman A; Chitnis C; Alano P; Baum J; Pradel G; Lavazec C; Ménard R, 2016, 'Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes', Cell Host and Microbe, vol. 20, pp. 618 - 630, http://dx.doi.org/10.1016/j.chom.2016.10.015
    Journal articles | 2016
    Delves MJ; Straschil U; Ruecker A; Miguel-Blanco C; Marques S; Dufour AC; Baum J; Sinden RE, 2016, 'Routine in vitro culture of P. Falciparum gametocytes to evaluate novel transmission-blocking interventions', Nature Protocols, vol. 11, pp. 1668 - 1680, http://dx.doi.org/10.1038/nprot.2016.096
    Journal articles | 2016
    Johnson S; Rahmani R; Drew DR; Williams MJ; Wilkinson M; Tan YH; Huang JX; Tonkin CJ; Beeson JG; Baum J; Smith BJ; Baell JB, 2016, 'Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion', Journal of Medicinal Chemistry, vol. 59, pp. 10994 - 11005, http://dx.doi.org/10.1021/acs.jmedchem.6b01109
    Journal articles | 2016
    Koch M; Baum J, 2016, 'The mechanics of malaria parasite invasion of the human erythrocyte - towards a reassessment of the host cell contribution', Cellular Microbiology, vol. 18, pp. 319 - 329, http://dx.doi.org/10.1111/cmi.12557
    Journal articles | 2016
    Olshina MA; Baumann H; Willison KR; Baum J, 2016, 'Plasmodium actin is incompletely folded by heterologous protein-folding machinery and likely requires the native Plasmodium chaperonin complex to enter a mature functional state', FASEB Journal, vol. 30, pp. 405 - 416, http://dx.doi.org/10.1096/fj.15-276618
    Journal articles | 2016
    Riglar DT; Whitehead L; Cowman AF; Rogers KL; Baum J, 2016, 'Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion', Journal of Cell Science, vol. 129, pp. 228 - 242, http://dx.doi.org/10.1242/jcs.177741
    Journal articles | 2016
    Tardieux I; Baum J, 2016, 'Reassessing the mechanics of parasite motility and host-cell invasion', Journal of Cell Biology, vol. 214, pp. 507 - 515, http://dx.doi.org/10.1083/JCB.201605100
    Journal articles | 2016
    Zuccala ES; Satchwell TJ; Angrisano F; Tan YH; Wilson MC; Heesom KJ; Baum J, 2016, 'Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19766
    Journal articles | 2015
    Baum J; Frischknecht F, 2015, 'Motorizing pathogens', Seminars in Cell and Developmental Biology, vol. 46, pp. 78 - 81, http://dx.doi.org/10.1016/j.semcdb.2015.09.019
    Journal articles | 2015
    Haase S; Zimmermann D; Olshina MA; Wilkinson M; Fisher F; Tan YH; Stewart RJ; Tonkin CJ; Wong W; Kovar DR; Baum J, 2015, 'Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites', Molecular Biology of the Cell, vol. 26, pp. 3001 - 3012, http://dx.doi.org/10.1091/mbc.E14-10-1427
    Journal articles | 2015
    Olshina MA; Angrisano F; Marapana DS; Riglar DT; Bane K; Wong W; Catimel B; Yin MX; Holmes AB; Frischknecht F; Kovar DR; Baum J, 2015, 'Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites', Malaria Journal, vol. 14, http://dx.doi.org/10.1186/s12936-015-0801-5
    Journal articles | 2015
    Wilson DW; Goodman CD; Sleebs BE; Weiss GE; de Jong NWM; Angrisano F; Langer C; Baum J; Crabb BS; Gilson PR; McFadden GI; Beeson JG, 2015, 'Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum', BMC Biology, vol. 13, http://dx.doi.org/10.1186/s12915-015-0162-0
    Journal articles | 2014
    Dasgupta S; Auth T; Gov NS; Satchwell TJ; Hanssen E; Zuccala ES; Riglar DT; Toye AM; Betz T; Baum J; Gompper G, 2014, 'Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte', Biophysical Journal, vol. 107, pp. 43 - 54, http://dx.doi.org/10.1016/j.bpj.2014.05.024
    Journal articles | 2014
    Kan A; Tan YH; Angrisano F; Hanssen E; Rogers KL; Whitehead L; Mollard VP; Cozijnsen A; Delves MJ; Crawford S; Sinden RE; Mcfadden GI; Leckie C; Bailey J; Baum J, 2014, 'Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility', Cellular Microbiology, vol. 16, pp. 734 - 750, http://dx.doi.org/10.1111/cmi.12283
    Journal articles | 2014
    Wong W; Bai XC; Brown A; Fernandez IS; Hanssen E; Condron M; Tan YH; Baum J; Scheres SHW, 2014, 'Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine', eLife, vol. 2014, http://dx.doi.org/10.7554/eLife.03080
    Journal articles | 2014
    Wong W; Webb AI; Olshina MA; Infusini G; Tan YH; Hanssen E; Catimel B; Suarez C; Condron M; Angrisano F; Nebl T; Kovar DR; Baum J, 2014, 'A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface', Journal of Biological Chemistry, vol. 289, pp. 4043 - 4054, http://dx.doi.org/10.1074/jbc.M113.523365
    Journal articles | 2014
    Zuccala E; Satchwell T; Angrisano F; Marapana D; Tan Y-H; Toye A; Baum J, 2014, 'Remodelling of the erythrocyte cytoskeleton during P. falciparum merozoite invasion', Malaria Journal, vol. 13, http://dx.doi.org/10.1186/1475-2875-13-s1-p96
    Journal articles | 2013
    Baum J, 2013, 'A complete molecular understanding of malaria parasite invasion of the human erythrocyte: Are we there yet?', Pathogens and Global Health, vol. 107, pp. 107, http://dx.doi.org/10.1179/2047772413Z.000000000121
    Journal articles | 2013
    Dahan-Pasternak N; Nasereddin A; Kolevzon N; Pe'er M; Wong W; Shinder V; Turnbull L; Whitchurch CB; Elbaum M; Gilberger TW; Yavin E; Baum J; Dzikowski R, 2013, 'Pfsec13 is an unusual chromatin-associated nucleoporin of plasmodium falciparum that is essential for parasite proliferation in human erythrocytes', Journal of Cell Science, vol. 126, pp. 3055 - 3069, http://dx.doi.org/10.1242/jcs.122119
    Journal articles | 2013
    Hanssen E; Dekiwadia C; Riglar DT; Rug M; Lemgruber L; Cowman AF; Cyrklaff M; Kudryashev M; Frischknecht F; Baum J; Ralph SA, 2013, 'Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion', Cellular Microbiology, vol. 15, pp. 1457 - 1472, http://dx.doi.org/10.1111/cmi.12132
    Journal articles | 2013
    Healer J; Thompson JK; Riglar DT; Wilson DW; Chiu YHC; Miura K; Chen L; Hodder AN; Long CA; Hansen DS; Baum J; Cowman AF, 2013, 'Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0072504
    Journal articles | 2013
    Lemgruber L; Kudryashev M; Dekiwadia C; Riglar DT; Baum J; Stahlberg H; Ralph SA; Frischknecht F, 2013, 'Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast', Malaria Journal, vol. 12, http://dx.doi.org/10.1186/1475-2875-12-25
    Journal articles | 2013
    Makkonen M; Bertling E; Chebotareva NA; Baum J; Lappalainen P, 2013, 'Mammalian and Malaria Parasite Cyclase-associated Proteins Catalyze Nucleotide Exchange on G-actin through a Conserved Mechanism', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, pp. 984 - 994, http://dx.doi.org/10.1074/jbc.M112.435719
    Journal articles | 2013
    Regev-Rudzki N; Wilson DW; Carvalho TG; Sisquella X; Coleman BM; Rug M; Bursac D; Angrisano F; Gee M; Hill AF; Baum J; Cowman AF, 2013, 'Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles', Cell, vol. 153, pp. 1120 - 1133, http://dx.doi.org/10.1016/j.cell.2013.04.029
    Journal articles | 2013
    Riglar DT; Baum J, 2013, 'Static and dynamic imaging of erythrocyte invasion and early intra-erythrocytic development in plasmodium falciparum', Methods in Molecular Biology, vol. 923, pp. 269 - 280, http://dx.doi.org/10.1007/978-1-62703-26-7_18
    Journal articles | 2013
    Riglar DT; Rogers KL; Hanssen E; Turnbull L; Bullen HE; Charnaud SC; Przyborski J; Gilson PR; Whitchurch CB; Crabb BS; Baum J; Cowman AF, 2013, 'Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes', Nature Communications, vol. 4, http://dx.doi.org/10.1038/ncomms2449
    Journal articles | 2012
    Angrisano F; Delves MJ; Sturm A; Mollard V; McFadden GI; Sinden RE; Baum J, 2012, 'A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle', Molecular and Biochemical Parasitology, vol. 182, pp. 93 - 96, http://dx.doi.org/10.1016/j.molbiopara.2011.11.008
    Journal articles | 2012
    Angrisano F; Riglar D; Sturm A; Volz J; Delves MJ; Zuccala E; Turnbull L; Dekiwadia C; Olshina MA; Marapana DS; Wong W; Mollard V; Bradin CH; Tonkin CJ; Gunning P; Ralph SA; Whitchurch CB; Sinden RE; Cowman AF; McFadden GI; Baum J, 2012, 'Spatial localisation of actin filaments across developmental stages of the malaria parasite', PLoS ONE, vol. 7, pp. Article number e32188, http://dx.doi.org/10.1371/journal.pone.0032188
    Journal articles | 2012
    Angrisano F; Tan YH; Sturm A; McFadden GI; Baum J, 2012, 'Malaria parasite colonisation of the mosquito midgut - Placing the Plasmodium ookinete centre stage', International Journal for Parasitology, vol. 42, pp. 519 - 527, http://dx.doi.org/10.1016/j.ijpara.2012.02.004
    Journal articles | 2012
    Baum J; Saliba KJ; Cooke BM, 2012, 'Editorial - Molecular Approaches to Malaria 2012 (MAM 2012)', International Journal for Parasitology, vol. 42, pp. 517, http://dx.doi.org/10.1016/j.ijpara.2012.05.001
    Journal articles | 2012
    Bullen HE; Charnaud SC; Kalanon M; Riglar DT; Dekiwadia C; Kangwanrangsan N; Torii M; Tsuboi T; Baum J; Ralph SA; Cowman AF; De Koning-Ward TF; Crabb BS; Gilsona PR, 2012, 'Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)', Journal of Biological Chemistry, vol. 287, pp. 7871 - 7884, http://dx.doi.org/10.1074/jbc.M111.328591
    Journal articles | 2012
    Cowman AF; Berry D; Baum J, 2012, 'The cellular and molecular basis for malaria parasite invasion of the human red blood cell', Journal of Cell Biology, vol. 198, pp. 961 - 971, http://dx.doi.org/10.1083/jcb.201206112
    Journal articles | 2012
    Marapana DS; Wilson DW; Zuccala ES; Dekiwadia CD; Beeson JG; Ralph SA; Baum J, 2012, 'Malaria Parasite Signal Peptide Peptidase is an ER-Resident Protease Required for Growth but not for Invasion', Traffic, vol. 13, pp. 1457 - 1465, http://dx.doi.org/10.1111/j.1600-0854.2012.01402.x
    Journal articles | 2012
    Olshina MA; Wong W; Baum J, 2012, 'Holding back the microfilament - Structural insights into actin and the actin-monomer-binding proteins of apicomplexan parasites', IUBMB Life, vol. 64, pp. 370 - 377, http://dx.doi.org/10.1002/iub.1014
    Journal articles | 2012
    Volz JC; Bártfai R; Petter M; Langer C; Josling GA; Tsuboi T; Schwach F; Baum J; Rayner JC; Stunnenberg HG; Duffy MF; Cowman AF, 2012, 'PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division', Cell Host and Microbe, vol. 11, pp. 7 - 18, http://dx.doi.org/10.1016/j.chom.2011.11.011
    Journal articles | 2012
    Zhang JG; Czabotar PE; Policheni AN; Caminschi I; San Wan S; Kitsoulis S; Tullett KM; Robin AY; Brammananth R; van Delft MF; Lu J; O'Reilly LA; Josefsson EC; Kile BT; Chin WJ; Mintern JD; Olshina MA; Wong W; Baum J; Wright MD; Huang DCS; Mohandas N; Coppel RL; Colman PM; Nicola NA; Shortman K; Lahoud MH, 2012, 'The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments', Immunity, vol. 36, pp. 646 - 657, http://dx.doi.org/10.1016/j.immuni.2012.03.009
    Journal articles | 2012
    Zuccala ES; Gout AM; Dekiwadia C; Marapana DS; Angrisano F; Turnbull L; Riglar DT; Rogers KL; Whitchurch CB; Ralph SA; Speed TP; Baum J, 2012, 'Subcompartmentalisation of Proteins in the Rhoptries Correlates with Ordered Events of Erythrocyte Invasion by the Blood Stage Malaria Parasite', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0046160
    Journal articles | 2012
    de Azevedo MF; Gilson PR; Gabriel HB; Simões RF; Angrisano F; Baum J; Crabb BS; Wunderlich G, 2012, 'Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0040981
    Journal articles | 2011
    Baum J; Billker O; Bousema T; Dinglasan R; McGovern V; Mota MM; Mueller I; Sinden R, 2011, 'A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies', PLOS MEDICINE, vol. 8, http://dx.doi.org/10.1371/journal.pmed.1000399
    Journal articles | 2011
    Baum J; Cowman AF, 2011, 'Revealing a parasite's invasive trick', Science, vol. 333, pp. 410 - 411, http://dx.doi.org/10.1126/science.1209875
    Journal articles | 2011
    Chen L; Lopaticki S; Riglar DT; Dekiwadia C; Uboldi AD; Tham WH; O'Neill MT; Richard D; Baum J; Ralph SA; Cowman AF, 2011, 'An egf-like protein forms a complex with pfrh5 and is required for invasion of human erythrocytes by plasmodium falciparum', PLoS Pathogens, vol. 7, http://dx.doi.org/10.1371/journal.ppat.1002199
    Journal articles | 2011
    Riglar DT; Richard D; Wilson DW; Boyle MJ; Dekiwadia C; Turnbull L; Angrisano F; Marapana DS; Rogers KL; Whitchurch CB; Beeson JG; Cowman AF; Ralph SA; Baum J, 2011, 'Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte', Cell Host and Microbe, vol. 9, pp. 9 - 20, http://dx.doi.org/10.1016/j.chom.2010.12.003
    Journal articles | 2011
    Triglia T; Chen L; Lopaticki S; Dekiwadia C; Riglar DT; Hodder AN; Ralph SA; Baum J; Cowman AF, 2011, 'Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRH2a and b binding domains', PLoS Pathogens, vol. 7, http://dx.doi.org/10.1371/journal.ppat.1002075
    Journal articles | 2011
    Wong W; Skau CT; Marapana DS; Hanssen E; Taylord NL; Riglar DT; Zuccala ES; Angrisano F; Lewis H; Catimel B; Clarke OB; Kershaw NJ; Perugini MA; Kovar DR; Gulbis JM; Baum J, 2011, 'Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 9869 - 9874, http://dx.doi.org/10.1073/pnas.1018927108
    Journal articles | 2011
    Yeoman JA; Hanssen E; Maier AG; Klonis N; Maco B; Baum J; Turnbull L; Whitchurch CB; Dixon MWA; Tilley L, 2011, 'Tracking glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum', Eukaryotic Cell, vol. 10, pp. 556 - 564, http://dx.doi.org/10.1128/EC.00244-10
    Journal articles | 2011
    Zuccala ES; Baum J, 2011, 'Cytoskeletal and membrane remodelling during malaria parasite invasion of the human erythrocyte', British Journal of Haematology, vol. 154, pp. 680 - 689, http://dx.doi.org/10.1111/j.1365-2141.2011.08766.x
    Journal articles | 2010
    Boyle MJ; Wilson DW; Richards JS; Riglar DT; Tetteh KKA; Conway DJ; Ralph SA; Baum J; Beeson JG, 2010, 'Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, pp. 14378 - 14383, http://dx.doi.org/10.1073/pnas.1009198107
    Journal articles | 2010
    Richard D; MacRaild CA; Riglar DT; Chan JA; Foley M; Baum J; Ralph SA; Norton RS; Cowman AF, 2010, 'Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites', Journal of Biological Chemistry, vol. 285, pp. 14815 - 14822, http://dx.doi.org/10.1074/jbc.M109.080770
    Journal articles | 2010
    Riglar D; Richard D; Boyle M; Wilson D; Angrisano F; Turnbull L; Whitchurch C; Cowman A; Beeson J; Ralph S; Baum J, 2010, 'Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte', Malaria Journal, vol. 9, http://dx.doi.org/10.1186/1475-2875-9-s2-o25
    Journal articles | 2010
    Riglar D; Richard D; Boyle M; Wilson D; Angrisano F; Turnbull L; Whitchurch C; Cowman A; Beeson J; Ralph S; Baum J, 2010, 'Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte', Malaria Journal, vol. 9, http://dx.doi.org/10.1186/1475-2875-9-s2-p42
    Journal articles | 2009
    Baum J; Chen L; Healer J; Lopaticki S; Boyle M; Triglia T; Ehlgen F; Ralph SA; Beeson JG; Cowman AF, 2009, 'Reticulocyte-binding protein homologue 5 - An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum', International Journal for Parasitology, vol. 39, pp. 371 - 380, http://dx.doi.org/10.1016/j.ijpara.2008.10.006
    Journal articles | 2009
    Baum J; Papenfuss AT; Mair GR; Janse CJ; Vlachou D; Waters AP; Cowman AF; Crabb BS; De Koning-Ward TF, 2009, 'Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites', Nucleic Acids Research, vol. 37, pp. 3788 - 3798, http://dx.doi.org/10.1093/nar/gkp239
    Journal articles | 2009
    Maier AG; Baum J; Smith B; Conway DJ; Cowman AF, 2009, 'Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum', Infection and Immunity, vol. 77, pp. 1689 - 1699, http://dx.doi.org/10.1128/IAI.01331-08
    Journal articles | 2008
    Baum J; Gilberger TW; Frischknecht F; Meissner M, 2008, 'Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma', Trends in Parasitology, vol. 24, pp. 557 - 563, http://dx.doi.org/10.1016/j.pt.2008.08.006
    Journal articles | 2008
    Baum J; Tonkin CJ; Paul AS; Rug M; Smith BJ; Gould SB; Richard D; Pollard TD; Cowman AF, 2008, 'A Malaria Parasite Formin Regulates Actin Polymerization and Localizes to the Parasite-Erythrocyte Moving Junction during Invasion', Cell Host and Microbe, vol. 3, pp. 188 - 198, http://dx.doi.org/10.1016/j.chom.2008.02.006
    Journal articles | 2006
    Baum J; Papenfuss AT; Baum B; Speed TP; Cowman AF, 2006, 'Regulation of apicomplexan actin-based motility', Nature Reviews Microbiology, vol. 4, pp. 621 - 628, http://dx.doi.org/10.1038/nrmicro1465
    Journal articles | 2006
    Baum J; Richard D; Healer J; Rug M; Krnajski Z; Gilberger TW; Green JL; Holder AA; Cowman AF, 2006, 'A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites', Journal of Biological Chemistry, vol. 281, pp. 5197 - 5208, http://dx.doi.org/10.1074/jbc.M509807200
    Journal articles | 2005
    Baum J; Maier AG; Good RT; Simpson KM; Cowman AF, 2005, 'Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions', PLoS Pathogens, vol. 1, pp. 0299 - 0309, http://dx.doi.org/10.1371/journal.ppat.0010037
    Journal articles | 2005
    Marti M; Baum J; Rug M; Tilley L; Cowman AF, 2005, 'Signal-mediated export of proteins from the malaria parasite to the host erythrocyte', Journal of Cell Biology, vol. 171, pp. 587 - 592, http://dx.doi.org/10.1083/jcb.200508051
    Journal articles | 2005
    Simpson KM; Baum J; Good RT; Winzeler EA; Cowman AF; Speed TP, 2005, 'A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays', International Journal for Parasitology, vol. 35, pp. 523 - 531, http://dx.doi.org/10.1016/j.ijpara.2005.02.010
    Journal articles | 2004
    Greenblatt CL; Baum J; Klein BY; Nachshon S; Koltunov V; Cano RJ, 2004, 'Micrococcus luteus - Survival in amber', Microbial Ecology, vol. 48, pp. 120 - 127, http://dx.doi.org/10.1007/s00248-003-2016-5
    Journal articles | 2003
    Baum J; Pinder M; Conway DJ, 2003, 'Erythrocyte invasion phenotypes of Plasmodium falciparum in the Gambia', Infection and Immunity, vol. 71, pp. 1856 - 1863, http://dx.doi.org/10.1128/IAI.71.4.1856-1863.2003
    Journal articles | 2003
    Baum J; Thomas AW; Conway DJ, 2003, 'Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax', Genetics, vol. 163, pp. 1327 - 1336
    Journal articles | 2002
    Baum J; Ward RH; Conway DJ, 2002, 'Natural selection on the erythrocyte surface', Molecular Biology and Evolution, vol. 19, pp. 223 - 229, http://dx.doi.org/10.1093/oxfordjournals.molbev.a004075
    Journal articles | 2002
    Conway DJ; Baum J, 2002, 'In the blood - The remarkable ancestry of Plasmodium falciparum', Trends in Parasitology, vol. 18, pp. 351 - 355, http://dx.doi.org/10.1016/S1471-4922(02)02330-9
    Journal articles | 2001
    Binks RH; Baum J; Oduola AMJ; Arnot DE; Babiker HA; Kremsner PG; Roper C; Greenwood BM; Conway DJ, 2001, 'Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene', Molecular and Biochemical Parasitology, vol. 114, pp. 63 - 70, http://dx.doi.org/10.1016/S0166-6851(01)00240-7
  • Preprints | 2021
    Benns HJ; Storch M; Falco J; Fisher FR; Alves E; Wincott CJ; Baum J; Baldwin GS; Weerapana E; Tate EW; Child MA, 2021, Prioritization of antimicrobial targets by CRISPR-based oligo recombineering, http://dx.doi.org/10.1101/2021.02.04.429737
    Preprints | 2020
    Blake T; Haase S; Baum J, 2020, Actomyosin forces and the energetics of red blood cell invasion by the malaria parasitePlasmodium falciparum, http://dx.doi.org/10.1101/2020.06.25.171900
    Preprints | 2020
    Moussaoui D; Robblee J; Auguin D; Krementsova E; Haase S; Blake T; Baum J; Robert-Paganin J; Trybus K; Houdusse A, 2020, Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis, http://dx.doi.org/10.1101/2020.06.30.179788
    Preprints | 2020
    Witmer K; Dahalan F; Delves M; Yahiya S; Watson O; Straschil U; Chiwcharoen D; Sornboon B; Pukrittayakamee S; Pearson R; Howick V; Lawniczak M; White N; Dondorp A; Okell L; Ruecker A; Chotivanich K; Baum J, 2020, Artemisinin-resistant malaria parasites show enhanced transmission to mosquitoes under drug pressure, http://dx.doi.org/10.1101/2020.02.04.933572
    Preprints | 2019
    Ashdown G; Dimon M; Fan M; Terán FS-R; Witmer K; Gaboriau D; Armstrong Z; Hazard J; Ando M; Baum J, 2019, A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens, http://dx.doi.org/10.1101/2019.12.19.882480
    Preprints | 2019
    Wang X; Wilkinson M; Lin X; Ren R; Willison K; Ivanov A; Baum J; Edel J, 2019, Single-molecule nanopore sensing of actin dynamics and drug binding, http://dx.doi.org/10.1101/829150
    Preprints | 2019
    Wilkinson M; Lai H-E; Freemont P; Baum J, 2019, A biosynthetic platform for antimalarial drug discovery, http://dx.doi.org/10.1101/814715
    Conference Papers | 2018
    Malpartida-Cardenas K; Miscourides N; Yu LS; Baum J; Rodriguez-Manzano J; Georgiou P, 2018, 'A CMOS-based diagnostic system for detection of artemisinin-resistant malaria', in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, pp. 871 - 873
    Preprints | 2017
    Delves M; Marques S; Ruecker A; Straschil U; Miguel-Blanco C; López-Barragá M; Lelièvre J; Molina I; Wree M; Okitsu S; Winzeler E; Li F; Vinetz J; Sheppard S; Guedes J; Guerra N; Herreros E; Sinden R; Baum J, 2017, Failure of in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes arises because of poor gamete fertilisation, http://dx.doi.org/10.1101/216721
    Preprints |
    Baumann H; Matthews H; Li M; Hu JJ; Willison KR; Baum J, A high-throughput in vitro translation screen towards discovery of novel antimalarial protein translation inhibitors, http://dx.doi.org/10.1101/248740
    Preprints |
    Blight J; Sala KA; Atcheson E; Kramer H; El-Turabi A; Real E; Dahalan FA; Bettencourt P; Dickinson E; Alves E; Salman AM; Janse CJ; Ashcroft F; Hill AVS; Reyes-Sandoval A; Blagborough AM; Baum J, Dissection-independent production of a protective whole-sporozoite malaria vaccine, http://dx.doi.org/10.1101/2020.06.22.164756
    Preprints |
    Bookwalter CS; Tay CL; McCrorie R; Previs MJ; Krementsova EB; Fagnant PM; Baum J; Trybus KM, Binding of a Newly Identified Essential Light Chain to ExpressedPlasmodium falciparumClass XIV Myosin Enhances Actin Motility, http://dx.doi.org/10.1101/127118
    Preprints |
    Davidson MS; Yahiya S; Chmielewski J; O’Donnell AJ; Gurung P; Jeninga M; Prommana P; Andrew D; Petter M; Uthaipibull C; Boyle M; Ashdown GW; Dvorin JD; Reece SE; Wilson DW; Ando DM; Dimon M; Baum J, Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks, http://dx.doi.org/10.1101/2021.01.26.21250284
    Preprints |
    Del Rosario M; Periz J; Pavlou G; Lyth O; Latorre-Barragan F; Das S; Pall GS; Stortz JF; Lemgruber L; Baum J; Tardieux I; Meissner M, Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion, http://dx.doi.org/10.1101/646463
    Preprints | 2020
    Haase S; Condron M; Miller D; Cherkaoui D; Jordan S; Gulbis J; Baum J, 2020, Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum, http://dx.doi.org/10.1101/2020.06.22.165258
    Preprints |
    Koch M; Cegla J; Jones B; Lu Y; Mallat Z; Blagborough A; Angrisano F; Baum J, The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection, http://dx.doi.org/10.1101/630251
    Preprints | 2022
    Malpartida-Cardenas K; Baum J; Cunnington A; Georgiou P; Rodriguez-Manzano J, 2022, Electricity-free nucleic acid extraction method from dried blood spots on filter paper for point-of-care diagnostics, http://dx.doi.org/10.1101/2022.07.28.501845
    Preprints |
    Malpartida-Cardenas K; Miscourides N; Rodriguez-Manzano J; Yu LS; Baum J; Georgiou P, Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform, http://dx.doi.org/10.1101/638221
    Preprints |
    Real E; Howick VM; Dahalan F; Witmer K; Cudini J; Andradi-Brown C; Blight J; Davidson MS; Dogga SK; Reid AJ; Baum J; Lawniczak MKN, A single-cell atlas of Plasmodium falciparum transmission through the mosquito, http://dx.doi.org/10.1101/2020.10.11.333179
    Preprints |
    Satchwell TJ; Wright KE; Haydn-Smith KL; Terán FS-R; Hawksworth J; Frayne J; Toye AM; Baum J, Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements, http://dx.doi.org/10.1101/495853
    Preprints |
    Yahiya S; Jordan S; Smith HX; Gaboriau DCA; Famodimu MT; Dahalan FA; Churchyard A; Ashdown GW; Baum J, 4D live-cell imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum, http://dx.doi.org/10.1101/2021.07.28.454129
    Preprints |
    Yahiya S; Saunders CN; Straschil U; Fischer OJ; Rueda-Zubiaurre A; Haase S; Vizcay-Barrena G; Jordan S; Hassan S; Delves MJ; Tate EW; Barnard A; Fuchter MJ; Baum J, Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development, http://dx.doi.org/10.1101/2021.06.14.448287

Current funding for the Baum lab comes from:

  • The Wellcome Trust (UK)
  • The Bill & Melinda Gates Foundation (US)
  • NIH (US)
  • The RoseTrees Trust (UK)

  • 2020 Imperial College London President's Awards for Excellence in Societal Engagement.
  • 2017, 2018 and 2019 Nomination Best Teaching Award. 2018 Nominated and Short-listed for Best Feedback Award by Imperial College Union Student Academic Choice Awards.
  • 2013 Merck Millipore Research Medal from the Australian Society for Biochemistry and Molecular Biology (ASBMB).
  • 2011 Walter + Eliza Hall Institute Burnet Prize.
  • 2009 Victorian/Tasmania Young Tall Poppy Science Award Winner.
  • 2007 ARC/NHMRC Australian Parasitological Society Early Career Researcher award

  • Development of novel, multi-epitope malaria vaccines
  • Dissection-independent isolation of malaria parasite sporozoites
  • Cell free protein translation by in vitro translation (IVT) using Plasmodium cell lysate
  • Digital point-of-care diagnostics for malaria and other infectious diseases
  • High throughput drug screening for antimalarials
  • Cell biology - with a core focus on malaria parasite cell motility and general cell biology