Professor Jeff   Holst
Professor

Professor Jeff Holst

BSc (Hons), PhD

medicine-health
School of Medical Sciences

Professor Jeff Holst leads the Translational Cancer Metabolism Laboratory in the Adult Cancer Program at the University of NSW. He completed his PhD at St Vincent’s Hospital/University of NSW and undertook postdoctoral studies at St Jude Children’s Research Hospital in the USA (2003-2006). He returned to Australia in 2006, before starting his own lab at the Centenary Institute in 2008. In 2018, he was recruited to the University of NSW, taking up a joint position in the School of Medical Sciences and the Prince of Wales Clinical School, located within the Lowy Cancer Research Centre.

Phone
+61-2-9065 8953
Location
Level 2 | Lowy Cancer Research Centre C25 UNSW SYDNEY NSW 2052 AUSTRALIA

Publications

  • Books | 2006
    Professor Jeff Holst
    Holst J; Rasko JEJ, 2006, The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells, http://dx.doi.org/10.1016/S0076-6879(06)20006-5
  • Journal articles | 2021
    Professor Jeff Holst
    Wang Q; Guan YF; Hancock SE; Wahi K; van Geldermalsen M; Zhang BK; Pang A; Nagarajah R; Mak B; Freidman N; Horvath LG; Turner N; Holst J, 2021, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth', Journal of Pathology, vol. 254, pp. 135 - 146, http://dx.doi.org/10.1002/path.5665
    Journal articles | 2021
    Professor Jeff Holst
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, vol. 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    Professor Jeff Holst
    Mandigo AC; Yuan W; Xu K; Gallagher P; Pang A; Guan YF; Shafi AA; Thangavel C; Sheehan B; Bogdan D; Paschalis A; McCann JJ; Laufer TS; Gordon N; Vasilevskaya IA; Dylgjeri E; Chand SN; Schiewer MJ; Domingo-Domenech J; Den RB; Holst J; McCue PA; de Bono JS; McNair C; Knudsen KE, 2021, 'RB/E2F1 as a master regulator of cancer cell metabolism in advanced disease.', Cancer Discov, http://dx.doi.org/10.1158/2159-8290.CD-20-1114
    Journal articles | 2020
    Professor Jeff Holst
    Huxley C; Wibowo M; Lum KY; Gordon S; D'Hyon S; Guan H; Wang X; Chen Y; Si M; Wang M; White JM; Wahi K; Wang Q; Holst J; Davis RA, 2020, 'Synthesis of bilocularin A carbamate derivatives and their evaluation as leucine transport inhibitors in prostate cancer cells', Phytochemistry, vol. 179, http://dx.doi.org/10.1016/j.phytochem.2020.112478
    Journal articles | 2020
    Professor Jeff Holst
    Freidman N; Chen I; Wu Q; Briot C; Holst J; Font J; Vandenberg R; Ryan R, 2020, 'Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer', Neurochemical Research, vol. 45, pp. 1268 - 1286, http://dx.doi.org/10.1007/s11064-019-02934-x
    Journal articles | 2020
    Professor Jeff Holst
    Nassar ZD; Mah CY; Dehairs J; Burvenich IJG; Irani S; Centenera MM; Helm M; Shrestha RK; Moldovan M; Don AS; Holst J; Scott AM; Horvath LG; Lynn DJ; Selth LA; Hoy AJ; Swinnen JV; Butler LM, 2020, 'Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis', eLife, vol. 9, pp. 1 - 34, http://dx.doi.org/10.7554/eLife.54166
    Journal articles | 2020
    Professor Jeff Holst
    Mandigo AC; McNair C; Ku K; Pang A; Guan YF; Holst J; Brown M; Kelly WK; Knudsen KE, 2020, 'Molecular underpinnings of RB status as a biomarker of poor outcome in advanced prostate cancer.', Journal of Clinical Oncology, vol. 38, pp. 189 - 189, http://dx.doi.org/10.1200/jco.2020.38.6_suppl.189
    Journal articles | 2019
    Professor Jeff Holst
    Zhang BK; Moran AM; Bailey CG; Rasko JEJ; Holst J; Wang Q, 2019, 'EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer', Cell Communication and Signaling, vol. 17, http://dx.doi.org/10.1186/s12964-019-0400-0
    Journal articles | 2019
    Professor Jeff Holst
    da Silva IP; Wang KYX; Wilmott JS; Holst J; Carlino MS; Park JJ; Quek C; Wongchenko M; Yan Y; Mann G; Johnson DB; McQuade JL; Rai R; Kefford RF; Rizos H; Scolyer RA; Yang JYH; Long GV; Menzies AM, 2019, 'Distinct molecular profiles and immunotherapy treatment outcomes of V600E and V600K BRAF-mutant melanoma', Clinical Cancer Research, vol. 25, pp. 1272 - 1279, http://dx.doi.org/10.1158/1078-0432.CCR-18-1680
    Journal articles | 2019
    Professor Jeff Holst
    Gordon S; Wibowo M; Wang Q; Holst J; Davis RA, 2019, 'Dihydro-β-agarofurans from the Australian rainforest plant Denhamia celastroides that inhibit leucine transport in prostate cancer cells', Magnetic Resonance in Chemistry, vol. 57, pp. 101 - 109, http://dx.doi.org/10.1002/mrc.4801
    Journal articles | 2019
    Professor Jeff Holst
    Balaban S; Nassar ZD; Zhang AY; Hosseini-Beheshti E; Centenera MM; Schreuder M; Lin HM; Aishah A; Varney B; Liu-Fu F; Lee LS; Nagarajan SR; Shearer RF; Hardie RA; Raftopulos NL; Kakani MS; Saunders DN; Holst J; Horvath LG; Butler LM; Hoy AJ, 2019, 'Extracellular fatty acids are the major contributor to lipid synthesis in prostate cancer', Molecular Cancer Research, vol. 17, pp. 949 - 962, http://dx.doi.org/10.1158/1541-7786.MCR-18-0347
    Journal articles | 2019
    Professor Jeff Holst
    Guo D; Lui GYL; Lai SL; Wilmott JS; Tikoo S; Jackett LA; Quek C; Brown DL; Sharp DM; Kwan RYQ; Chacon D; Wong JH; Beck D; van Geldermalsen M; Holst J; Thompson JF; Mann GJ; Scolyer RA; Stow JL; Weninger W; Haass NK; Beaumont KA, 2019, 'RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes', International Journal of Cancer, vol. 144, pp. 3070 - 3085, http://dx.doi.org/10.1002/ijc.32064
    Journal articles | 2019
    Professor Jeff Holst
    Bröer A; Gauthier-Coles G; Rahimi F; van Geldermalsen M; Dorsch D; Wegener A; Holst J; Bröer S, 2019, 'Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells', Journal of Biological Chemistry, vol. 294, pp. 4012 - 4026, http://dx.doi.org/10.1074/jbc.RA118.006378
    Journal articles | 2019
    Professor Jeff Holst
    Gide TN; Quek C; Menzies AM; Tasker AT; Shang P; Holst J; Madore J; Lim SY; Velickovic R; Wongchenko M; Yan Y; Lo S; Carlino MS; Guminski A; Saw RPM; Pang A; McGuire HM; Palendira U; Thompson JF; Rizos H; Silva IPD; Batten M; Scolyer RA; Long GV; Wilmott JS, 2019, 'Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy', Cancer Cell, vol. 35, pp. 238 - 255.e6, http://dx.doi.org/10.1016/j.ccell.2019.01.003
    Journal articles | 2019
    Professor Jeff Holst
    Wahi K; Holst J, 2019, 'ASCT2: a potential cancer drug target', Expert Opinion on Therapeutic Targets, vol. 23, pp. 555 - 558, http://dx.doi.org/10.1080/14728222.2019.1627328
    Journal articles | 2019
    Professor Jeff Holst
    Gao D; Pinello N; Nguyen TV; Thoeng A; Nagarajah R; Holst J; Rasko JEJ; Wong JJL, 2019, 'DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis', Epigenomics, vol. 11, pp. 95 - 109, http://dx.doi.org/10.2217/epi-2018-0050
    Journal articles | 2019
    Professor Jeff Holst
    de Bock CE; Down M; Baidya K; Sweron B; Boyd AW; Fiers M; Burns GF; Molloy TJ; Lock RB; Soulier J; Taghon T; Van Vlierberghe P; Cools J; Holst J; Thorne RF, 2019, 'T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development', Haematologica, vol. 104, pp. e204 - e207, http://dx.doi.org/10.3324/haematol.2018.198424
    Journal articles | 2018
    Professor Jeff Holst
    van Geldermalsen M; Quek LE; Turner N; Freidman N; Pang A; Guan YF; Krycer JR; Ryan R; Wang Q; Holst J, 2018, 'Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways', BMC Cancer, vol. 18, http://dx.doi.org/10.1186/s12885-018-4599-8
    Journal articles | 2018
    Professor Jeff Holst
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2018, 'Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors', Phytochemistry, vol. 148, pp. 71 - 77, http://dx.doi.org/10.1016/j.phytochem.2018.01.009
    Journal articles | 2018
    Professor Jeff Holst
    Rajasekhar M; Schmitz U; Flamant S; Wong JJL; Bailey CG; Ritchie W; Holst J; Rasko JEJ, 2018, 'Identifying microRNA determinants of human myelopoiesis', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-24203-7
    Journal articles | 2018
    Professor Jeff Holst
    Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; Van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B; Brink R; Jolly CJ, 2018, 'SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, pp. 4921 - 4926, http://dx.doi.org/10.1073/pnas.1719771115
    Journal articles | 2018
    Professor Jeff Holst
    Garibsingh RAA; Otte NJ; Ndaru E; Colas C; Grewer C; Holst J; Schlessinger A, 2018, 'Homology modeling informs ligand discovery for the glutamine transporter ASCT2', Frontiers in Chemistry, vol. 6, pp. 279, http://dx.doi.org/10.3389/fchem.2018.00279
    Journal articles | 2018
    Professor Jeff Holst
    Ryan RM; Holst J, 2018, 'Regulation of SLC1A4 and SLC1A5 in prostate cancer-letter', Molecular Cancer Research, vol. 16, pp. 1809 - 1810, http://dx.doi.org/10.1158/1541-7786.MCR-18-0239
    Journal articles | 2017
    Professor Jeff Holst
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2017, 'Celastrofurans A-G: Dihydro-β-Agarofurans from the Australian Rainforest Vine Celastrus subspicata and Their Inhibitory Effect on Leucine Transport in Prostate Cancer Cells', Journal of Natural Products, vol. 80, pp. 1918 - 1925, http://dx.doi.org/10.1021/acs.jnatprod.7b00220
    Journal articles | 2017
    Professor Jeff Holst
    Chen Y; Ma J; Lu W; Tian M; Thauvin M; Yuan C; Volovitch M; Wang Q; Holst J; Liu M; Vriz S; Ye S; Wang L; Li D, 2017, 'Heritable expansion of the genetic code in mouse and zebrafish', Cell Research, vol. 27, pp. 294 - 297, http://dx.doi.org/10.1038/cr.2016.145
    Journal articles | 2017
    Professor Jeff Holst
    Marshall AD; van Geldermalsen M; Otte NJ; Lum T; Vellozzi M; Thoeng A; Pang A; Nagarajah R; Zhang B; Wang Q; Anderson L; Rasko JEJ; Holst J, 2017, 'ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma', Oncogenesis, vol. 6, pp. e367, http://dx.doi.org/10.1038/oncsis.2017.70
    Journal articles | 2017
    Professor Jeff Holst
    Wong JJL; Gao D; Nguyen TV; Kwok CT; Van Geldermalsen M; Middleton R; Pinello N; Thoeng A; Nagarajah R; Holst J; Ritchie W; Rasko JEJ, 2017, 'Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms15134
    Journal articles | 2017
    Professor Jeff Holst
    Guan FHX; Bailey CG; Metierre C; O’Young P; Gao D; Khoo TL; Holst J; Rasko JEJ, 2017, 'The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo', Journal of Hematology and Oncology, vol. 10, http://dx.doi.org/10.1186/s13045-017-0446-7
    Journal articles | 2017
    Professor Jeff Holst
    Zhao Y; Ting KK; Li J; Cogger VC; Chen J; Johansson-Percival A; Ngiow SF; Holst J; Grau G; Goel S; Muller T; Dejana E; McCaughan G; Smyth MJ; Ganss R; Vadas MA; Gamble JR, 2017, 'Targeting vascular endothelial-cadherin in tumor-associated blood vessels promotes T-cell–mediated immunotherapy', Cancer Research, vol. 77, pp. 4434 - 4447, http://dx.doi.org/10.1158/0008-5472.CAN-16-3129
    Journal articles | 2017
    Professor Jeff Holst
    Balaban S; Shearer RF; Lee LS; van Geldermalsen M; Schreuder M; Shtein HC; Cairns R; Thomas KC; Fazakerley DJ; Grewal T; Holst J; Saunders DN; Hoy AJ, 2017, 'Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration', CANCER & METABOLISM, vol. 5, http://dx.doi.org/10.1186/s40170-016-0163-7
    Journal articles | 2016
    Professor Jeff Holst
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Dihydro-β-agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells', Asian Journal of Organic Chemistry, vol. 5, pp. 1461 - 1466, http://dx.doi.org/10.1002/ajoc.201600462
    Journal articles | 2016
    Professor Jeff Holst
    Marshall AD; van Geldermalsen M; Otte NJ; Anderson LA; Lum T; Vellozzi MA; Zhang BK; Thoeng A; Wang Q; Rasko JEJ; Holst J, 2016, 'LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma', International Journal of Cancer, vol. 139, pp. 2529 - 2539, http://dx.doi.org/10.1002/ijc.30371
    Journal articles | 2016
    Professor Jeff Holst
    Van Geldermalsen M; Wang Q; Nagarajah R; Marshall AD; Thoeng A; Gao D; Ritchie W; Feng Y; Bailey CG; Deng N; Harvey K; Beith JM; Selinger CI; O'Toole SA; Rasko JEJ; Holst J, 2016, 'ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer', Oncogene, vol. 35, pp. 3201 - 3208, http://dx.doi.org/10.1038/onc.2015.381
    Journal articles | 2016
    Professor Jeff Holst
    Wibowo M; Levrier C; Sadowski MC; Nelson CC; Wang Q; Holst J; Healy PC; Hofmann A; Davis RA, 2016, 'Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis', Journal of Natural Products, vol. 79, pp. 1445 - 1453, http://dx.doi.org/10.1021/acs.jnatprod.6b00190
    Journal articles | 2016
    Professor Jeff Holst
    Wong JJL; Au AYM; Gao D; Pinello N; Kwok CT; Thoeng A; Lau KA; Gordon JEA; Schmitz U; Feng Y; Nguyen TV; Middleton R; Bailey CG; Holst J; Rasko JEJ; Ritchie W, 2016, 'RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever', Nucleic Acids Research, vol. 44, pp. 2888 - 2897, http://dx.doi.org/10.1093/nar/gkw041
    Journal articles | 2016
    Professor Jeff Holst
    Xi Z; Yao M; Li Y; Xie C; Holst J; Liu T; Cai S; Lao Y; Tan H; Xu HX; Dong Q, 2016, 'Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation', Cell Death and Disease, vol. 7, http://dx.doi.org/10.1038/cddis.2016.123
    Journal articles | 2016
    Professor Jeff Holst
    Shklovskaya E; Terry AM; Guy TV; Buckley A; Bolton HA; Zhu E; Holst J; De St Groth BF, 2016, 'Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen', Immunology and Cell Biology, vol. 94, pp. 593 - 603, http://dx.doi.org/10.1038/icb.2016.14
    Journal articles | 2016
    Professor Jeff Holst
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Inside Cover: Dihydro-β -agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells (Asian J. Org. Chem. 12/2016)', Asian Journal of Organic Chemistry, vol. 5, pp. 1412 - 1412, http://dx.doi.org/10.1002/ajoc.201600548
    Journal articles | 2015
    Professor Jeff Holst
    Grkovic T; Pouwer RH; Wang Q; Guymer GP; Holst J; Quinn RJ, 2015, 'LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis', Journal of Natural Products, vol. 78, pp. 1215 - 1220, http://dx.doi.org/10.1021/np500968t
    Journal articles | 2015
    Professor Jeff Holst
    Yao M; Xie C; Kiang MY; Teng Y; Harman D; Tiffen J; Wang Q; Sved P; Bao S; Witting P; Holst J; Dong Q, 2015, 'Targeting of cytosolic phospholipase A2a impedes cell cycle re-entry of quiescent prostate cancer cells', Oncotarget, vol. 6, pp. 34458 - 34474, http://dx.doi.org/10.18632/oncotarget.5277
    Journal articles | 2015
    Professor Jeff Holst
    Wang Q; Holst J, 2015, 'L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia', American Journal of Cancer Research, vol. 5, pp. 1281 - 1294
    Journal articles | 2015
    Professor Jeff Holst
    Wang Q; Hardie RA; Hoy AJ; Van Geldermalsen M; Gao D; Fazli L; Sadowski MC; Balaban S; Schreuder M; Nagarajah R; Wong JJL; Metierre C; Pinello N; Otte NJ; Lehman ML; Gleave M; Nelson CC; Bailey CG; Ritchie W; Rasko JE; Holst J, 2015, 'Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development', Journal of Pathology, vol. 236, pp. 278 - 289, http://dx.doi.org/10.1002/path.4518
    Journal articles | 2015
    Professor Jeff Holst
    Leach DA; Need EF; Toivanen R; Trotta AP; Palenthorpe HM; Tamblyn DJ; Kopsaftis T; England GM; Smith E; Drew PA; Pinnock CB; Lee P; Holst J; Risbridger GP; Chopra S; DeFranco DB; Taylor RA; Buchanan G, 2015, 'Erratum: Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome [Oncotarget. 2015; 6:16135-16150]', Oncotarget, vol. 6, pp. 36923, http://dx.doi.org/10.18632/oncotarget.6263
    Journal articles | 2015
    Professor Jeff Holst
    Hnit SST; Xie C; Yao M; Holst J; Bensoussan A; De Souza P; Li Z; Dong Q, 2015, 'P27Kip1 signaling: Transcriptional and post-translational regulation', International Journal of Biochemistry and Cell Biology, vol. 68, pp. 9 - 14, http://dx.doi.org/10.1016/j.biocel.2015.08.005
    Journal articles | 2015
    Professor Jeff Holst
    Leach DA; Need EF; Toivanen R; Trotta AP; Palenthorpe HM; Tamblyn DJ; Kopsaftis T; England GM; Smith E; Drew PA; Pinnock CB; Lee P; Holst J; Risbridger GP; Chopra S; DeFranco DB; Taylor RA; Buchanan G, 2015, 'Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome', Oncotarget, vol. 6, pp. 16135 - 16150, http://dx.doi.org/10.18632/oncotarget.3873
    Journal articles | 2015
    Professor Jeff Holst
    Colas C; Grewer C; Otte NJ; Gameiro A; Albers T; Singh K; Shere H; Bonomi M; Holst J; Schlessinger A, 2015, 'Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening', PLoS Computational Biology, vol. 11, http://dx.doi.org/10.1371/journal.pcbi.1004477
    Journal articles | 2015
    Professor Jeff Holst
    Colas C; Grewer C; Gameiro A; Albers T; Singh K; Otte NJ; Shere H; Massimiliano B; Holst J; Schlessinger A, 2015, 'Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening', Biophysical Journal, vol. 108, pp. 54a - 54a, http://dx.doi.org/10.1016/j.bpj.2014.11.329
    Journal articles | 2015
    Professor Jeff Holst
    van Geldermalsen M; Wang Q; Bailey CG; Feng Y; Nagarajah R; Marshall A; Thoeng A; O'Toole S; Rasko JEJ; Holst J, 2015, 'Targeting the ASCT2 glutamine uptake and metabolism pathway in triple-negative breast cancer', Annals of Oncology, vol. 26, pp. iii31, http://dx.doi.org/10.1093/annonc/mdv121.04
    Journal articles | 2014
    Professor Jeff Holst
    Wang Q; Beaumont KA; Otte NJ; Font J; Bailey CG; Van Geldermalsen M; Sharp DM; Tiffen JC; Ryan RM; Jormakka M; Haass NK; Rasko JEJ; Holst J, 2014, 'Targeting glutamine transport to suppress melanoma cell growth', International Journal of Cancer, vol. 135, pp. 1060 - 1071, http://dx.doi.org/10.1002/ijc.28749
    Journal articles | 2014
    Professor Jeff Holst
    Wang Q; Grkovic T; Font J; Bonham S; Pouwer RH; Bailey CG; Moran AM; Ryan RM; Rasko JEJ; Jormakka M; Quinn RJ; Holst J, 2014, 'Monoterpene glycoside ESK246 from pittosporum targets LAT3 amino acid transport and prostate cancer cell growth', ACS Chemical Biology, vol. 9, pp. 1369 - 1376, http://dx.doi.org/10.1021/cb500120x
    Journal articles | 2014
    Professor Jeff Holst
    Wong JJL; Ritchie W; Gao D; Lau KA; Gonzalez M; Choudhary A; Taft RJ; Rasko JEJ; Holst J, 2014, 'Identification of nuclear-enriched miRNAs during mouse granulopoiesis', Journal of Hematology and Oncology, vol. 7, http://dx.doi.org/10.1186/1756-8722-7-42
    Journal articles | 2014
    Professor Jeff Holst
    Wang Q; Hardie R-A; Balaban S; Schreuder M; Hoy A; van Geldermalsen M; Fazli L; Nagarajah R; Bailey C; Rasko J; Holst J, 2014, 'Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer', CANCER & METABOLISM, vol. 2, http://dx.doi.org/10.1186/2049-3002-2-S1-P27
    Journal articles | 2014
    Professor Jeff Holst
    Wong JJL; Holst J, 2014, 'Changes in CpG methylation marks differentiation of human myeloid progenitors to neutrophils.', Stem Cell Investig, vol. 1, pp. 10, http://dx.doi.org/10.3978/j.issn.2306-9759.2014.05.01
    Journal articles | 2013
    Professor Jeff Holst
    Wang Q; Tiffen J; Bailey CG; Lehman ML; Ritchie W; Fazli L; Metierre C; Feng YJ; Li E; Gleave M; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2013, 'Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth, and tumor development', Journal of the National Cancer Institute, vol. 105, pp. 1463 - 1473, http://dx.doi.org/10.1093/jnci/djt241
    Journal articles | 2013
    Professor Jeff Holst
    Tiffen JC; Bailey CG; Marshall AD; Metierre C; Feng Y; Wang Q; Watson SL; Holst J; Rasko JEJ, 2013, 'The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells', International Journal of Cancer, vol. 133, pp. 1603 - 1613, http://dx.doi.org/10.1002/ijc.28184
    Journal articles | 2013
    Professor Jeff Holst
    Wong JJL; Ritchie W; Ebner OA; Selbach M; Wong JWH; Huang Y; Gao D; Pinello N; Gonzalez M; Baidya K; Thoeng A; Khoo TL; Bailey CG; Holst J; Rasko JEJ, 2013, 'XOrchestrated intron retention regulates normal granulocyte differentiation', Cell, vol. 154, pp. 583 - 595, http://dx.doi.org/10.1016/j.cell.2013.06.052
    Journal articles | 2013
    Professor Jeff Holst
    Khoo TL; Xiros N; Guan F; Orellana D; Holst J; Joshua DE; Rasko JEJ, 2013, 'Performance evaluation of the abbott CELL-DYN emerald for use as a bench-top analyzer in a research setting', International Journal of Laboratory Hematology, vol. 35, pp. 447 - 456, http://dx.doi.org/10.1111/ijlh.12040
    Journal articles | 2013
    Professor Jeff Holst
    Holst J, 2013, 'Letter to the Editor', International Journal of Pharmaceutics, vol. 455, pp. 393, http://dx.doi.org/10.1016/j.ijpharm.2013.07.008
    Journal articles | 2012
    Professor Jeff Holst
    Wang Q; Bailey CG; Ng C; Tiffen J; Thoeng A; Minnas V; Lehman ML; Hendy SC; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2012, 'Androgen receptor and nutrient signaling pathways coordinate increased amino acid transport in prostate cancer progression.', BMC Proceedings, vol. 6, pp. P23 - P23, http://dx.doi.org/10.1186/1753-6561-6-s3-p23
    Journal articles | 2012
    Professor Jeff Holst
    De Bock CE; Ardjmand A; Molloy TJ; Bone SM; Johnstone D; Campbell DM; Shipman KL; Yeadon TM; Holst J; Spanevello MD; Nelmes G; Stewart D; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2012, 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, vol. 26, pp. 918 - 926, http://dx.doi.org/10.1038/leu.2011.319
    Journal articles | 2011
    Professor Jeff Holst
    Wang Q; Bailey CG; Ng C; Tiffen J; Thoeng A; Minhas V; Lehman ML; Hendy SC; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2011, 'Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression', Cancer Research, vol. 71, pp. 7525 - 7536, http://dx.doi.org/10.1158/0008-5472.CAN-11-1821
    Journal articles | 2011
    Professor Jeff Holst
    Bröer A; Juelich T; Vanslambrouck JM; Tietze N; Solomon PS; Holst J; Bailey CG; Rasko JEJ; Bröer S, 2011, 'Impaired nutrient signaling and body weight control in a Na + neutral amino acid cotransporter (Slc6a19)-deficient mouse', Journal of Biological Chemistry, vol. 286, pp. 26638 - 26651, http://dx.doi.org/10.1074/jbc.M111.241323
    Journal articles | 2011
    Professor Jeff Holst
    Ardjmand A; Bock CED; Molloy TJ; Bone SM; Johnstone D; Campbell DM; Shipman KL; Yeadon TM; Holst J; Spanevello MD; Catchpoole DR; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2011, 'Altered expression of Fat1 cadherin, a novel tumor marker for acute lymphoblastic leukemia', Clinical Biochemistry, vol. 44, pp. S71 - S71, http://dx.doi.org/10.1016/j.clinbiochem.2011.08.154
    Journal articles | 2010
    Professor Jeff Holst
    Flamant S; Ritchie W; Guilhot J; Holst J; Bonnet ML; Chomel JC; Guilhot F; Turhan AG; Rasko JEJ, 2010, 'Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia', Haematologica, vol. 95, pp. 1325 - 1333, http://dx.doi.org/10.3324/haematol.2009.020636
    Journal articles | 2010
    Professor Jeff Holst
    Tiffen JC; Bailey CG; Ng C; Rasko JEJ; Holst J, 2010, 'Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo', Molecular Cancer, vol. 9, http://dx.doi.org/10.1186/1476-4598-9-299
    Journal articles | 2010
    Professor Jeff Holst
    Vanslambrouck JM; Bröer A; Thavyogarajah T; Holst J; Bailey CG; Bröer S; Rasko JEJ, 2010, 'Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria', Biochemical Journal, vol. 428, pp. 397 - 407, http://dx.doi.org/10.1042/BJ20091667
    Journal articles | 2010
    Professor Jeff Holst
    Taft RJ; Simons C; Nahkuri S; Oey H; Korbie DJ; Mercer TR; Holst J; Ritchie W; Wong JJL; Rasko JEJ; Rokhsar DS; Degnan BM; Mattick JS, 2010, 'Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans', Nature Structural and Molecular Biology, vol. 17, pp. 1030 - 1034, http://dx.doi.org/10.1038/nsmb.1841
    Journal articles | 2010
    Professor Jeff Holst
    Wang H; Holst J; Woo SR; Guy C; Bettini M; Wang Y; Shafer A; Naramura M; Mingueneau M; Dragone LL; Hayes SM; Malissen B; Band H; Vignali DAA, 2010, 'Tonic ubiquitylation controls T-cell receptor: CD3 complex expression during T-cell development', EMBO Journal, vol. 29, pp. 1285 - 1298, http://dx.doi.org/10.1038/emboj.2010.10
    Journal articles | 2010
    Professor Jeff Holst
    Holst J; Watson S; Lord MS; Eamegdool SS; Bax DV; Nivison-Smith LB; Kondyurin A; Ma L; Overhauser AF; Weiss AS; Rasko JEJ, 2010, 'Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells', Nature Biotechnology, vol. 28, pp. 1123 - 1130, http://dx.doi.org/10.1038/nbt.1687
    Journal articles | 2010
    Professor Jeff Holst
    Kranias G; Watt LF; Carpenter H; Holst J; Ludowyke R; Strack S; Sim ATR; Verrills NM, 2010, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, vol. 22, pp. 1882 - 1890, http://dx.doi.org/10.1016/j.cellsig.2010.07.017
    Journal articles | 2010
    Professor Jeff Holst
    Tiffen JC; Bailey CG; Ng C; Watson SL; Loukinov DI; Lobanenkov VV; Holst J; Rasko JEJ, 2010, '700 BORIS and its paralogue CTCF exhibit similar biological functions', European Journal of Cancer Supplements, vol. 8, pp. 176 - 177, http://dx.doi.org/10.1016/s1359-6349(10)71497-x
    Journal articles | 2009
    Professor Jeff Holst
    Rajasekhar M; Holst J; Rasko JEJ, 2009, 'MicroRNA expression in myeloid differentiation', Cytokine, vol. 48, pp. 78 - 78, http://dx.doi.org/10.1016/j.cyto.2009.07.269
    Journal articles | 2008
    Professor Jeff Holst
    Holst J; Wang H; Eder KD; Workman CJ; Boyd KL; Baquet Z; Singh H; Forbes K; Chruscinski A; Smeyne R; van Oers NSC; Utz PJ; Vignali DAA, 2008, 'Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity', Nature Immunology, vol. 9, pp. 658 - 666, http://dx.doi.org/10.1038/ni.1611
    Journal articles | 2006
    Professor Jeff Holst
    El Kasmi KC; Holst J; Coffre M; Mielke L; De Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG; Alexander W; Vignali DAA; Watowich SS; Ernst M; Hilton DJ; Murray PJ, 2006, 'General nature of the STAT3-activated anti-inflammatory response', Journal of Immunology, vol. 177, pp. 7880 - 7888, http://dx.doi.org/10.4049/jimmunol.177.11.7880
    Journal articles | 2006
    Professor Jeff Holst
    Holst J; Vignali KM; Burton AR; Vignali DAA, 2006, 'Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.', Nature methods, vol. 3, pp. 191 - 197, http://dx.doi.org/10.1038/nmeth858
    Journal articles | 2006
    Professor Jeff Holst
    Holst J; Szymczak-Workman AL; Vignali KM; Burton AR; Workman CJ; Vignali DAA, 2006, 'Generation of T-cell receptor retrogenic mice', Nature Protocols, vol. 1, pp. 406 - 417, http://dx.doi.org/10.1038/nprot.2006.61
    Journal articles | 2006
    Professor Jeff Holst
    Holst J; Vignali KM; Burton AR; Vignali DAA, 2006, 'Erratum: Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice (Nature Methods) (2006) vol. 3 (191-197))', Nature Methods, vol. 3, pp. 327, http://dx.doi.org/10.1038/nmeth0406-327
    Journal articles | 2003
    Professor Jeff Holst
    Sim ATR; Baldwin ML; Rostas JAP; Holst J; Ludowyke RI, 2003, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, vol. 373, pp. 641 - 659, http://dx.doi.org/10.1042/BJ20030484
    Journal articles | 2003
    Professor Jeff Holst
    Sim ATR; Holst J; Ludowyke RI, 2003, '[10] Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology, vol. 366, pp. 113 - 124, http://dx.doi.org/10.1016/S0076-6879(03)66010-6
    Journal articles | 2003
    Professor Jeff Holst
    Sim A; Holst JA; Ludowyke RI, 2003, 'Protein phosphatase translocation in RBL-2H3 cells', Methods in Enzymology, vol. 366, pp. 113 - 124, https://www.ncbi.nlm.nih.gov/pubmed/14674244
    Journal articles | 2002
    Professor Jeff Holst
    Holst J; Sim ATR; Ludowyke RI, 2002, 'Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells', Molecular Biology of the Cell, vol. 13, pp. 1083 - 1098, http://dx.doi.org/10.1091/mbc.01-12-0587
    Journal articles | 2000
    Professor Jeff Holst
    Ludowyke RI; Holst J; Mudge LM; Sim ATR, 2000, 'Transient translocation and activation of protein phosphatase 2A during mast cell secretion', Journal of Biological Chemistry, vol. 275, pp. 6144 - 6152, http://dx.doi.org/10.1074/jbc.275.9.6144
    Journal articles |
    Professor Jeff Holst
    Wang Q; Guan YF; Hancock SE; Wahi K; van Geldermalsen M; Zhang BK; Pang A; Nagarajah R; Mak B; Horvath LG; Turner N; Holst J, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo', , http://dx.doi.org/10.1101/2020.09.07.286997
  • Conference Abstracts | 2020
    Professor Jeff Holst
    Mandigo AC; McNair C; Ku K; Pang A; Guan YF; Holst J; Brown M; Kelly WK; Knudsen KE, 2020, 'Molecular underpinnings of RB status as a biomarker of poor outcome in advanced prostate cancer', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, San Francisco, CA, Vol. 38, presented at Genitourinary Cancers Symposium of the American-Society-of-Clinical-Oncology (ASCO), San Francisco, CA, 13 February 2020 - 15 February 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000529525900258&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Professor Jeff Holst
    van Geldermalsen M; Quek L-E; Turner N; Balaban S; Hoy A; Pang A; Guan YF; Wahi K; Wang Q; Holst J, 2019, 'Vulnerabilities in glutamine metabolism define triple-negative from Luminal A breast cancer subsets', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Antonio, TX, Vol. 80, presented at 42nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, 09 December 2019 - 14 December 2019, http://dx.doi.org/10.1158/1538-7445.SABCS19-P3-02-09
    Conference Papers | 2018
    Professor Jeff Holst
    Wang QK; Geldermalsen MV; Pang A; Zhang B; Holst J, 2018, 'Abstract A036: Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer', in Poster Presentations - Proffered Abstracts, American Association for Cancer Research, presented at Abstracts: AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; December 2-5, 2017; Orlando, Florida, http://dx.doi.org/10.1158/1538-7445.prca2017-a036
    Conference Papers | 2018
    Professor Jeff Holst
    GUO D; Lui GY; Sharp DM; Lai SL; Tikoo S; Kwan R; Geldermalsen MV; Holst J; Haass NK; Weninger W; Beaumont KA, 2018, 'Abstract 5167: Rab27a promotes melanoma cell invasion and metastasis via the regulation of exosome secretion', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL, http://dx.doi.org/10.1158/1538-7445.am2018-5167
    Conference Papers | 2018
    Professor Jeff Holst
    Geldermalsen MV; Quek L-E; Turner N; Balaban S; Hoy A; Wang Q; Holst J, 2018, 'Abstract B20: Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets', in Metabolism, American Association for Cancer Research, presented at Abstracts: AACR Special Conference: Advances in Breast Cancer Research; October 7-10, 2017; Hollywood, CA, http://dx.doi.org/10.1158/1557-3125.advbc17-b20
    Conference Papers | 2017
    Professor Jeff Holst
    van Geldermalsen M; Quek L-E; Turner N; Balaban S; Hoy A; Wang Q; Holst J, 2017, 'Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets.', in MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Hollywood, CA, pp. 72 - 72, presented at AACR Special Conference on Advances in Breast Cancer Research, Hollywood, CA, 07 October 2017 - 10 October 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440602000103&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Professor Jeff Holst
    Otte NJ; Broer A; O’Young P; van Geldermalsen M; Wang Q; Bailey CG; Broer S; Holst J, 2016, 'Abstract 1007: The amino acid transporter SNAT4: Potential role as a tumor suppressor in melanoma', in Molecular and Cellular Biology, Genetics, American Association for Cancer Research, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-1007
    Conference Papers | 2016
    Professor Jeff Holst
    van Geldermalsen M; Wang Q; Holst J, 2016, 'Abstract 1043: Targeting ASCT2-mediated glutamine uptake and metabolism in breast cancer', in Molecular and Cellular Biology, Genetics, American Association for Cancer Research, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-1043
    Conference Papers | 2015
    Professor Jeff Holst
    Wang Q; Hardie R-A; Hoy A; Fazli L; Bailey C; Rasko JEJ; Holst J, 2015, 'Abstract B14: Targeting amino acid transport to block mTORC1 and cell cycle in prostate cancer', in Molecular Regulation of the PI3K-mTOR Network, American Association for Cancer Research, presented at Abstracts: AACR Special Conference: Targeting the PI3K-mTOR Network in Cancer; September 14-17, 2014; Philadelphia, PA, http://dx.doi.org/10.1158/1538-8514.pi3k14-b14
    Conference Papers | 2013
    Professor Jeff Holst
    Klein A; Hambley TW; Bierbach U; Holst J, 2013, 'Novel Amidinediaminetricarboxylato Platinum(IV)-Anthraquinone Complexes for Targeting Tumours', in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, Grenoble, FRANCE, pp. S665 - S665, presented at 16th International Conference on Biological Inorganic Chemistry (ICBIC), Grenoble, FRANCE, 22 July 2013 - 26 July 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332835300601&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Jeff Holst
    Rasko J; Wong J; Ritchie W; Olivia E; Matthias S; Wong JWH; Huang Y; Gao D; Gonzalez M; Baidya K; Theong A; Khoo T-L; Bailey CG; Holst J, 2012, 'Intron Retention Coupled with Nonsense-Mediated Decay Determines Protein Expression and Nuclear Morphology in Granulopoiesis', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.112.112
    Conference Papers | 2002
    Professor Jeff Holst
    Holst J; Sim AT; Ludowyke RI, 2002, 'Regulation of myosin phosphorylation by protein phosphatase 2a in mast cells', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, SAN FRANCISCO, CALIFORNIA, pp. 53A - 53A, presented at 42nd Annual Meeting of the American-Society-for-Cell-Biology, SAN FRANCISCO, CALIFORNIA, 14 December 2002 - 18 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179569100297&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Awards

Grants

Charlie Teo Foundation Pilot Grant, Developing a metabolic roadmap to discover novel therapeutic avenues to starve glioblastoma. Jan 2021-Dec 2021 (CIA)

Tour de Cure Senior Research Grant, A new therapy targeting “gluttonous” prostate cancer cells Jan 2020-Dec 2020 (CIA)

Cancer Council NSW Project Grant, Targeting glutamine addiction of triple-negative breast cancer (TNBC). Jan 2018-Dec 2020 (CIA)

Cancer Council NSW Project Grant, Nutrient stress-mediated adaptive responses as novel targets in BRAF mutant melanoma. July 2017-Dec 2020 (CIA)

NHMRC/MRFF Lifting Clinical Trials and Registries Capacity Grant, Immunotherapy Targeting of Cytomegalovirus antigens in Glioblastoma: INTERROGATE-GBM. June 2018-June 2022 (CIC)

NHMRC Project Grant APP1144108 Metabolically Reprogramming the Stroma to Starve Pancreatic Tumours. Jan 2018-Dec 2020 (CID)

Avner Pancreatic Cancer Foundation, Starvation of pancreatic tumours by metabolically reprogramming both tumour and stromal cells. January 2019-December 2020 (CIC)

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