Professor Jeff Holst
Professor

Professor Jeff Holst

BSc (Hons), PhD

Medicine & Health
School of Biomedical Sciences

I am a fundamental and translational cancer researcher developing new ways to profile and target metabolic pathways in melanoma, glioblastoma, breast and prostate cancer. My research has focussed primarily on the role of uptake and metabolism of amino acids by cancer cells and how these integrate and cooperate with glucose metabolism to drive cell growth. My lab has developed a range of novel methods for exploring these metabolic processes in cancer, including 3D explant models for analysis of metabolism (metabolomics) and therapeutic development.

I am Director of Engagement and Industry Partnerships in the School of Biomedical Sciences at UNSW, and Director of the Adult Cancer Program. In addition, I am part of the Strategic Advisory Committee of the UNSW Cancer Theme.

Phone
+61-2-9065 8953
Location
Level 2 | Lowy Cancer Research Centre C25 UNSW SYDNEY NSW 2052 AUSTRALIA
  • Books | 2006
    Holst J; Rasko JE J, 2006, The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells, http://dx.doi.org/10.1016/S0076-6879(06)20006-5
  • Journal articles | 2023
    2023, 'Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models.', BJUI Compass, 4, pp. 44 - 58, http://dx.doi.org/10.1002/bco2.187
    Journal articles | 2023
    2023, 'Theranostic Activity of Ceria-Based Nanoparticles toward Parental and Metastatic Melanoma: 2D vs 3D Models', ACS Biomaterials Science and Engineering, 9, pp. 1053 - 1065, http://dx.doi.org/10.1021/acsbiomaterials.2c01258
    Journal articles | 2022
    2022, 'A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer', Clinical Cancer Research, 28, pp. 1446 - 1459, http://dx.doi.org/10.1158/1078-0432.CCR-21-1846
    Journal articles | 2022
    2022, 'Glutamine addiction promotes glucose oxidation in triple-negative breast cancer', Oncogene, 41, pp. 4066 - 4078, http://dx.doi.org/10.1038/s41388-022-02408-5
    Journal articles | 2022
    2022, 'Zwitterionic Amino Acid-Derived Polyacrylates as Smart Materials Exhibiting Cellular Specificity and Therapeutic Activity', Biomacromolecules, 23, pp. 2374 - 2387, http://dx.doi.org/10.1021/acs.biomac.2c00143
    Journal articles | 2021
    2021, 'A feedback loop between the 1 androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth: Cooperativity between 6PGD and AR drives prostate cancer growth', eLife, 10, http://dx.doi.org/10.7554/eLife.62592
    Journal articles | 2021
    2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    2021, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth', Journal of Pathology, 254, pp. 135 - 146, http://dx.doi.org/10.1002/path.5665
    Journal articles | 2021
    2021, 'Rb/e2f1 as a master regulator of cancer cell metabolism in advanced disease', Cancer Discovery, 11, pp. 2334 - 2353, http://dx.doi.org/10.1158/2159-8290.CD-20-1114
    Journal articles | 2021
    2021, 'Tp53 mutation is a prognostic factor in lower grade glioma and may influence chemotherapy efficacy', Cancers, 13, http://dx.doi.org/10.3390/cancers13215362
    Journal articles | 2020
    2020, 'Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer', Neurochemical Research, 45, pp. 1268 - 1286, http://dx.doi.org/10.1007/s11064-019-02934-x
    Journal articles | 2020
    2020, 'Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis', eLife, 9, pp. 1 - 34, http://dx.doi.org/10.7554/eLife.54166
    Journal articles | 2020
    2020, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo', , http://dx.doi.org/10.1101/2020.09.07.286997
    Journal articles | 2020
    2020, 'Molecular underpinnings of RB status as a biomarker of poor outcome in advanced prostate cancer.', Journal of Clinical Oncology, 38, pp. 189 - 189, http://dx.doi.org/10.1200/jco.2020.38.6_suppl.189
    Journal articles | 2020
    2020, 'Synthesis of bilocularin A carbamate derivatives and their evaluation as leucine transport inhibitors in prostate cancer cells', Phytochemistry, 179, http://dx.doi.org/10.1016/j.phytochem.2020.112478
    Journal articles | 2019
    2019, 'ASCT2: a potential cancer drug target', Expert Opinion on Therapeutic Targets, 23, pp. 555 - 558, http://dx.doi.org/10.1080/14728222.2019.1627328
    Journal articles | 2019
    2019, 'Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells', Journal of Biological Chemistry, 294, pp. 4012 - 4026, http://dx.doi.org/10.1074/jbc.RA118.006378
    Journal articles | 2019
    2019, 'DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis', Epigenomics, 11, pp. 95 - 109, http://dx.doi.org/10.2217/epi-2018-0050
    Journal articles | 2019
    2019, 'Dihydro-β-agarofurans from the Australian rainforest plant Denhamia celastroides that inhibit leucine transport in prostate cancer cells', Magnetic Resonance in Chemistry, 57, pp. 101 - 109, http://dx.doi.org/10.1002/mrc.4801
    Journal articles | 2019
    2019, 'Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy', Cancer Cell, 35, pp. 238 - 255.e6, http://dx.doi.org/10.1016/j.ccell.2019.01.003
    Journal articles | 2019
    2019, 'Distinct molecular profiles and immunotherapy treatment outcomes of V600E and V600K BRAF-mutant melanoma', Clinical Cancer Research, 25, pp. 1272 - 1279, http://dx.doi.org/10.1158/1078-0432.CCR-18-1680
    Journal articles | 2019
    2019, 'EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer', Cell Communication and Signaling, 17, http://dx.doi.org/10.1186/s12964-019-0400-0
    Journal articles | 2019
    2019, 'Extracellular fatty acids are the major contributor to lipid synthesis in prostate cancer', Molecular Cancer Research, 17, pp. 949 - 962, http://dx.doi.org/10.1158/1541-7786.MCR-18-0347
    Journal articles | 2019
    2019, 'RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes', International Journal of Cancer, 144, pp. 3070 - 3085, http://dx.doi.org/10.1002/ijc.32064
    Journal articles | 2019
    2019, 'T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development', Haematologica, 104, pp. e204 - e207, http://dx.doi.org/10.3324/haematol.2018.198424
    Journal articles | 2018
    Rajasekhar M; Schmitz U; Flamant S; Wong JJ L; Bailey CG; Ritchie W; Holst J; Rasko JE J, 2018, 'Identifying microRNA determinants of human myelopoiesis', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-24203-7
    Journal articles | 2018
    Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; Van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B; Brink R; Jolly CJ, 2018, 'SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4921 - 4926, http://dx.doi.org/10.1073/pnas.1719771115
    Journal articles | 2018
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2018, 'Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors', Phytochemistry, 148, pp. 71 - 77, http://dx.doi.org/10.1016/j.phytochem.2018.01.009
    Journal articles | 2018
    van Geldermalsen M; Quek LE; Turner N; Freidman N; Pang A; Guan YF; Krycer JR; Ryan R; Wang Q; Holst J, 2018, 'Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways', BMC Cancer, 18, http://dx.doi.org/10.1186/s12885-018-4599-8
    Journal articles | 2018
    2018, 'Homology modeling informs ligand discovery for the glutamine transporter ASCT2', Frontiers in Chemistry, 6, pp. 279, http://dx.doi.org/10.3389/fchem.2018.00279
    Journal articles | 2018
    2018, 'Regulation of SLC1A4 and SLC1A5 in prostate cancer-letter', Molecular Cancer Research, 16, pp. 1809 - 1810, http://dx.doi.org/10.1158/1541-7786.MCR-18-0239
    Journal articles | 2018
    2018, 'Targeting a solute carrier to metabolically reprogram tumour-promoting stromal cells in pancreatic cancer', Pancreatology, 18, pp. S156 - S156, http://dx.doi.org/10.1016/j.pan.2018.05.419
    Journal articles | 2017
    Chen Y; Ma J; Lu W; Tian M; Thauvin M; Yuan C; Volovitch M; Wang Q; Holst J; Liu M; Vriz S; Ye S; Wang L; Li D, 2017, 'Heritable expansion of the genetic code in mouse and zebrafish', Cell Research, 27, pp. 294 - 297, http://dx.doi.org/10.1038/cr.2016.145
    Journal articles | 2017
    Guan FH X; Bailey CG; Metierre C; O’Young P; Gao D; Khoo TL; Holst J; Rasko JE J, 2017, 'The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo', Journal of Hematology and Oncology, 10, http://dx.doi.org/10.1186/s13045-017-0446-7
    Journal articles | 2017
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2017, 'Celastrofurans A-G: Dihydro-β-Agarofurans from the Australian Rainforest Vine Celastrus subspicata and Their Inhibitory Effect on Leucine Transport in Prostate Cancer Cells', Journal of Natural Products, 80, pp. 1918 - 1925, http://dx.doi.org/10.1021/acs.jnatprod.7b00220
    Journal articles | 2017
    Wong JJ L; Gao D; Nguyen TV; Kwok CT; Van Geldermalsen M; Middleton R; Pinello N; Thoeng A; Nagarajah R; Holst J; Ritchie W; Rasko JE J, 2017, 'Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms15134
    Journal articles | 2017
    Zhao Y; Ting KK; Li J; Cogger VC; Chen J; Johansson-Percival A; Ngiow SF; Holst J; Grau G; Goel S; Muller T; Dejana E; McCaughan G; Smyth MJ; Ganss R; Vadas MA; Gamble JR, 2017, 'Targeting vascular endothelial-cadherin in tumor-associated blood vessels promotes T-cell–mediated immunotherapy', Cancer Research, 77, pp. 4434 - 4447, http://dx.doi.org/10.1158/0008-5472.CAN-16-3129
    Journal articles | 2017
    2017, 'ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma', Oncogenesis, 6, pp. e367, http://dx.doi.org/10.1038/oncsis.2017.70
    Journal articles | 2017
    2017, 'Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration', CANCER & METABOLISM, 5, http://dx.doi.org/10.1186/s40170-016-0163-7
    Journal articles | 2016
    Marshall AD; van Geldermalsen M; Otte NJ; Anderson LA; Lum T; Vellozzi MA; Zhang BK; Thoeng A; Wang Q; Rasko JE J; Holst J, 2016, 'LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma', International Journal of Cancer, 139, pp. 2529 - 2539, http://dx.doi.org/10.1002/ijc.30371
    Journal articles | 2016
    Shklovskaya E; Terry AM; Guy TV; Buckley A; Bolton HA; Zhu E; Holst J; De St Groth BF, 2016, 'Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen', Immunology and Cell Biology, 94, pp. 593 - 603, http://dx.doi.org/10.1038/icb.2016.14
    Journal articles | 2016
    Van Geldermalsen M; Wang Q; Nagarajah R; Marshall AD; Thoeng A; Gao D; Ritchie W; Feng Y; Bailey CG; Deng N; Harvey K; Beith JM; Selinger CI; O'Toole SA; Rasko JE J; Holst J, 2016, 'ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer', Oncogene, 35, pp. 3201 - 3208, http://dx.doi.org/10.1038/onc.2015.381
    Journal articles | 2016
    Wibowo M; Levrier C; Sadowski MC; Nelson CC; Wang Q; Holst J; Healy PC; Hofmann A; Davis RA, 2016, 'Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis', Journal of Natural Products, 79, pp. 1445 - 1453, http://dx.doi.org/10.1021/acs.jnatprod.6b00190
    Journal articles | 2016
    Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Dihydro-β-agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells', Asian Journal of Organic Chemistry, 5, pp. 1461 - 1466, http://dx.doi.org/10.1002/ajoc.201600462
    Journal articles | 2016
    Wong JJ L; Au AY M; Gao D; Pinello N; Kwok CT; Thoeng A; Lau KA; Gordon JE A; Schmitz U; Feng Y; Nguyen TV; Middleton R; Bailey CG; Holst J; Rasko JE J; Ritchie W, 2016, 'RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever', Nucleic Acids Research, 44, pp. 2888 - 2897, http://dx.doi.org/10.1093/nar/gkw041
    Journal articles | 2016
    Xi Z; Yao M; Li Y; Xie C; Holst J; Liu T; Cai S; Lao Y; Tan H; Xu HX; Dong Q, 2016, 'Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation', Cell Death and Disease, 7, http://dx.doi.org/10.1038/cddis.2016.123
    Journal articles | 2016
    2016, 'Inside Cover: Dihydro-β -agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells (Asian J. Org. Chem. 12/2016)', Asian Journal of Organic Chemistry, 5, pp. 1412 - 1412, http://dx.doi.org/10.1002/ajoc.201600548
    Journal articles | 2015
    Colas C; Grewer C; Otte NJ; Gameiro A; Albers T; Singh K; Shere H; Bonomi M; Holst J; Schlessinger A, 2015, 'Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening', PLoS Computational Biology, 11, http://dx.doi.org/10.1371/journal.pcbi.1004477
    Journal articles | 2015
    Grkovic T; Pouwer RH; Wang Q; Guymer GP; Holst J; Quinn RJ, 2015, 'LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis', Journal of Natural Products, 78, pp. 1215 - 1220, http://dx.doi.org/10.1021/np500968t
    Journal articles | 2015
    Hnit SS T; Xie C; Yao M; Holst J; Bensoussan A; De Souza P; Li Z; Dong Q, 2015, 'P27Kip1 signaling: Transcriptional and post-translational regulation', International Journal of Biochemistry and Cell Biology, 68, pp. 9 - 14, http://dx.doi.org/10.1016/j.biocel.2015.08.005
    Journal articles | 2015
    Leach DA; Need EF; Toivanen R; Trotta AP; Palenthorpe HM; Tamblyn DJ; Kopsaftis T; England GM; Smith E; Drew PA; Pinnock CB; Lee P; Holst J; Risbridger GP; Chopra S; DeFranco DB; Taylor RA; Buchanan G, 2015, 'Erratum: Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome [Oncotarget. 2015; 6:16135-16150]', Oncotarget, 6, pp. 36923, http://dx.doi.org/10.18632/oncotarget.6263
    Journal articles | 2015
    Leach DA; Need EF; Toivanen R; Trotta AP; Palenthorpe HM; Tamblyn DJ; Kopsaftis T; England GM; Smith E; Drew PA; Pinnock CB; Lee P; Holst J; Risbridger GP; Chopra S; DeFranco DB; Taylor RA; Buchanan G, 2015, 'Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome', Oncotarget, 6, pp. 16135 - 16150, http://dx.doi.org/10.18632/oncotarget.3873
    Journal articles | 2015
    Wang Q; Hardie RA; Hoy AJ; Van Geldermalsen M; Gao D; Fazli L; Sadowski MC; Balaban S; Schreuder M; Nagarajah R; Wong JJ L; Metierre C; Pinello N; Otte NJ; Lehman ML; Gleave M; Nelson CC; Bailey CG; Ritchie W; Rasko JE; Holst J, 2015, 'Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development', Journal of Pathology, 236, pp. 278 - 289, http://dx.doi.org/10.1002/path.4518
    Journal articles | 2015
    Wang Q; Holst J, 2015, 'L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia', American Journal of Cancer Research, 5, pp. 1281 - 1294
    Journal articles | 2015
    Yao M; Xie C; Kiang MY; Teng Y; Harman D; Tiffen J; Wang Q; Sved P; Bao S; Witting P; Holst J; Dong Q, 2015, 'Targeting of cytosolic phospholipase A2a impedes cell cycle re-entry of quiescent prostate cancer cells', Oncotarget, 6, pp. 34458 - 34474, http://dx.doi.org/10.18632/oncotarget.5277
    Journal articles | 2015
    2015, 'Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening', BIOPHYSICAL JOURNAL, 108, pp. 54A - 54A, http://dx.doi.org/10.1016/j.bpj.2014.11.329
    Journal articles | 2015
    2015, 'Targeting the ASCT2 glutamine uptake and metabolism pathway in triple-negative breast cancer', Annals of Oncology, 26, pp. iii31, http://dx.doi.org/10.1093/annonc/mdv121.04
    Journal articles | 2014
    Wang Q; Beaumont KA; Otte NJ; Font J; Bailey CG; Van Geldermalsen M; Sharp DM; Tiffen JC; Ryan RM; Jormakka M; Haass NK; Rasko JE J; Holst J, 2014, 'Targeting glutamine transport to suppress melanoma cell growth', International Journal of Cancer, 135, pp. 1060 - 1071, http://dx.doi.org/10.1002/ijc.28749
    Journal articles | 2014
    Wang Q; Grkovic T; Font J; Bonham S; Pouwer RH; Bailey CG; Moran AM; Ryan RM; Rasko JE J; Jormakka M; Quinn RJ; Holst J, 2014, 'Monoterpene glycoside ESK246 from pittosporum targets LAT3 amino acid transport and prostate cancer cell growth', ACS Chemical Biology, 9, pp. 1369 - 1376, http://dx.doi.org/10.1021/cb500120x
    Journal articles | 2014
    Wong JJ L; Holst J, 2014, 'Changes in CpG methylation marks differentiation of human myeloid progenitors to neutrophils.', Stem Cell Investig, 1, pp. 10, http://dx.doi.org/10.3978/j.issn.2306-9759.2014.05.01
    Journal articles | 2014
    Wong JJ L; Ritchie W; Gao D; Lau KA; Gonzalez M; Choudhary A; Taft RJ; Rasko JE J; Holst J, 2014, 'Identification of nuclear-enriched miRNAs during mouse granulopoiesis', Journal of Hematology and Oncology, 7, http://dx.doi.org/10.1186/1756-8722-7-42
    Journal articles | 2014
    2014, 'Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer', CANCER & METABOLISM, 2, http://dx.doi.org/10.1186/2049-3002-2-S1-P27
    Journal articles | 2013
    Holst J, 2013, 'Letter to the Editor', International Journal of Pharmaceutics, 455, pp. 393, http://dx.doi.org/10.1016/j.ijpharm.2013.07.008
    Journal articles | 2013
    Khoo TL; Xiros N; Guan F; Orellana D; Holst J; Joshua DE; Rasko JE J, 2013, 'Performance evaluation of the abbott CELL-DYN emerald for use as a bench-top analyzer in a research setting', International Journal of Laboratory Hematology, 35, pp. 447 - 456, http://dx.doi.org/10.1111/ijlh.12040
    Journal articles | 2013
    Tiffen JC; Bailey CG; Marshall AD; Metierre C; Feng Y; Wang Q; Watson SL; Holst J; Rasko JE J, 2013, 'The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells', International Journal of Cancer, 133, pp. 1603 - 1613, http://dx.doi.org/10.1002/ijc.28184
    Journal articles | 2013
    Wang Q; Tiffen J; Bailey CG; Lehman ML; Ritchie W; Fazli L; Metierre C; Feng YJ; Li E; Gleave M; Buchanan G; Nelson CC; Rasko JE J; Holst J, 2013, 'Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth, and tumor development', Journal of the National Cancer Institute, 105, pp. 1463 - 1473, http://dx.doi.org/10.1093/jnci/djt241
    Journal articles | 2013
    Wong JJ L; Ritchie W; Ebner OA; Selbach M; Wong JW H; Huang Y; Gao D; Pinello N; Gonzalez M; Baidya K; Thoeng A; Khoo TL; Bailey CG; Holst J; Rasko JE J, 2013, 'XOrchestrated intron retention regulates normal granulocyte differentiation', Cell, 154, pp. 583 - 595, http://dx.doi.org/10.1016/j.cell.2013.06.052
    Journal articles | 2012
    De Bock CE; Ardjmand A; Molloy TJ; Bone SM; Johnstone D; Campbell DM; Shipman KL; Yeadon TM; Holst J; Spanevello MD; Nelmes G; Catchpoole DR; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2012, 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, 26, pp. 918 - 926, http://dx.doi.org/10.1038/leu.2011.319
    Journal articles | 2012
    2012, 'Androgen receptor and nutrient signaling pathways coordinate increased amino acid transport in prostate cancer progression', BMC proceedings, 6, pp. P23 - P23, http://dx.doi.org/10.1186/1753-6561-6-s3-p23
    Journal articles | 2011
    Bröer A; Juelich T; Vanslambrouck JM; Tietze N; Solomon PS; Holst J; Bailey CG; Rasko JE J; Bröer S, 2011, 'Impaired nutrient signaling and body weight control in a Na + neutral amino acid cotransporter (Slc6a19)-deficient mouse', Journal of Biological Chemistry, 286, pp. 26638 - 26651, http://dx.doi.org/10.1074/jbc.M111.241323
    Journal articles | 2011
    Wang Q; Bailey CG; Ng C; Tiffen J; Thoeng A; Minhas V; Lehman ML; Hendy SC; Buchanan G; Nelson CC; Rasko JE J; Holst J, 2011, 'Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression', Cancer Research, 71, pp. 7525 - 7536, http://dx.doi.org/10.1158/0008-5472.CAN-11-1821
    Journal articles | 2011
    2011, 'Altered expression of Fat1 cadherin, a novel tumor marker for acute lymphoblastic leukemia', Clinical Biochemistry, 44, pp. S71 - S71, http://dx.doi.org/10.1016/j.clinbiochem.2011.08.154
    Journal articles | 2010
    Flamant S; Ritchie W; Guilhot J; Holst J; Bonnet ML; Chomel JC; Guilhot F; Turhan AG; Rasko JE J, 2010, 'Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia', Haematologica, 95, pp. 1325 - 1333, http://dx.doi.org/10.3324/haematol.2009.020636
    Journal articles | 2010
    Kranias G; Watt LF; Carpenter H; Holst J; Ludowyke R; Strack S; Sim AT R; Verrills NM, 2010, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22, pp. 1882 - 1890, http://dx.doi.org/10.1016/j.cellsig.2010.07.017
    Journal articles | 2010
    Taft RJ; Simons C; Nahkuri S; Oey H; Korbie DJ; Mercer TR; Holst J; Ritchie W; Wong JJ L; Rasko JE J; Rokhsar DS; Degnan BM; Mattick JS, 2010, 'Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans', Nature Structural and Molecular Biology, 17, pp. 1030 - 1034, http://dx.doi.org/10.1038/nsmb.1841
    Journal articles | 2010
    Tiffen JC; Bailey CG; Ng C; Rasko JE J; Holst J, 2010, 'Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo', Molecular Cancer, 9, http://dx.doi.org/10.1186/1476-4598-9-299
    Journal articles | 2010
    Vanslambrouck JM; Bröer A; Thavyogarajah T; Holst J; Bailey CG; Bröer S; Rasko JE J, 2010, 'Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria', Biochemical Journal, 428, pp. 397 - 407, http://dx.doi.org/10.1042/BJ20091667
    Journal articles | 2010
    Wang H; Holst J; Woo SR; Guy C; Bettini M; Wang Y; Shafer A; Naramura M; Mingueneau M; Dragone LL; Hayes SM; Malissen B; Band H; Vignali DA A, 2010, 'Tonic ubiquitylation controls T-cell receptor: CD3 complex expression during T-cell development', EMBO Journal, 29, pp. 1285 - 1298, http://dx.doi.org/10.1038/emboj.2010.10
    Journal articles | 2010
    2010, 'BORIS and its paralogue CTCF exhibit similar biological functions', EJC SUPPLEMENTS, 8, pp. 176 - 177, http://dx.doi.org/10.1016/S1359-6349(10)71497-X
    Journal articles | 2010
    2010, 'Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells', Nature Biotechnology, 28, pp. 1123 - 1130, http://dx.doi.org/10.1038/nbt.1687
    Journal articles | 2009
    2009, 'MicroRNA expression in myeloid differentiation', Cytokine, 48, pp. 78 - 78, http://dx.doi.org/10.1016/j.cyto.2009.07.269
    Journal articles | 2008
    Holst J; Wang H; Eder KD; Workman CJ; Boyd KL; Baquet Z; Singh H; Forbes K; Chruscinski A; Smeyne R; van Oers NS C; Utz PJ; Vignali DA A, 2008, 'Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity', Nature Immunology, 9, pp. 658 - 666, http://dx.doi.org/10.1038/ni.1611
    Journal articles | 2006
    El Kasmi KC; Holst J; Coffre M; Mielke L; De Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG; Alexander W; Vignali DA A; Watowich SS; Ernst M; Hilton DJ; Murray PJ, 2006, 'General nature of the STAT3-activated anti-inflammatory response', Journal of Immunology, 177, pp. 7880 - 7888, http://dx.doi.org/10.4049/jimmunol.177.11.7880
    Journal articles | 2006
    Holst J; Szymczak-Workman AL; Vignali KM; Burton AR; Workman CJ; Vignali DA A, 2006, 'Generation of T-cell receptor retrogenic mice', Nature Protocols, 1, pp. 406 - 417, http://dx.doi.org/10.1038/nprot.2006.61
    Journal articles | 2006
    Holst J; Vignali KM; Burton AR; Vignali DA A, 2006, 'Erratum: Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice (Nature Methods) (2006) vol. 3 (191-197))', Nature Methods, 3, pp. 327, http://dx.doi.org/10.1038/nmeth0406-327
    Journal articles | 2006
    Holst J; Vignali KM; Burton AR; Vignali DA A, 2006, 'Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.', Nature methods, 3, pp. 191 - 197, http://dx.doi.org/10.1038/nmeth858
    Journal articles | 2003
    Sim AT R; Baldwin ML; Rostas JA P; Holst J; Ludowyke RI, 2003, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373, pp. 641 - 659, http://dx.doi.org/10.1042/BJ20030484
    Journal articles | 2003
    Sim AT R; Holst J; Ludowyke RI, 2003, '[10] Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology, 366, pp. 113 - 124, http://dx.doi.org/10.1016/S0076-6879(03)66010-6
    Journal articles | 2003
    2003, 'Protein phosphatase translocation in RBL-2H3 cells', Methods in Enzymology, 366, pp. 113 - 124, https://www.ncbi.nlm.nih.gov/pubmed/14674244
    Journal articles | 2002
    Holst J; Sim AT R; Ludowyke RI, 2002, 'Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells', Molecular Biology of the Cell, 13, pp. 1083 - 1098, http://dx.doi.org/10.1091/mbc.01-12-0587
    Journal articles | 2000
    Ludowyke RI; Holst J; Mudge LM; Sim AT R, 2000, 'Transient translocation and activation of protein phosphatase 2A during mast cell secretion', Journal of Biological Chemistry, 275, pp. 6144 - 6152, http://dx.doi.org/10.1074/jbc.275.9.6144
  • Other | 2023
    2023, Data from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.c.6531392
    Other | 2023
    2023, Data from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.c.6531392.v1
    Other | 2023
    2023, Data from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.c.6512931.v1
    Other | 2023
    2023, Data from Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer, , http://dx.doi.org/10.1158/1541-7786.c.6540204.v1
    Other | 2023
    2023, Figure S1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428180
    Other | 2023
    2023, Figure S1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428180.v1
    Other | 2023
    2023, Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428177
    Other | 2023
    2023, Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428177.v1
    Other | 2023
    2023, Figure S3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428168
    Other | 2023
    2023, Figure S3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428168.v1
    Other | 2023
    2023, Figure S4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428165
    Other | 2023
    2023, Figure S4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428165.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484366
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484366.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484369
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484369.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484372
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484372.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484375
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484375.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484378
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484378.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484384
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484384.v1
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484390
    Other | 2023
    2023, Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484390.v1
    Other | 2023
    2023, Supplementary Figures 1-3 from Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer, , http://dx.doi.org/10.1158/1541-7786.22512309
    Other | 2023
    2023, Supplementary Figures 1-3 from Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer, , http://dx.doi.org/10.1158/1541-7786.22512309.v1
    Other | 2023
    2023, Supplementary Table 1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428162
    Other | 2023
    2023, Supplementary Table 1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428162.v1
    Other | 2023
    2023, Supplementary Table 2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428159
    Other | 2023
    2023, Supplementary Table 2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428159.v1
    Other | 2023
    2023, Supplementary Table 3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428156
    Other | 2023
    2023, Supplementary Table 3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428156.v1
    Other | 2023
    2023, Supplementary Table 4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428153
    Other | 2023
    2023, Supplementary Table 4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428153.v1
    Other | 2023
    2023, Supplementary Table from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484357
    Other | 2023
    2023, Supplementary Table from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484357.v1
    Other | 2023
    2023, Supplementary Table from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484360
    Other | 2023
    2023, Supplementary Table from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer, , http://dx.doi.org/10.1158/1078-0432.22484360.v1
    Conference Papers | 2022
    2022, 'ANTAGONISM OF DRD2 USING ONC201 INCREASED EXPRESSION OF ANTIGEN PRESENTATION PATHWAY PROTEINS IN DIFFUSE MIDLINE GLIOMA, RECRUITING TUMOR INFILTRATING LYMPHOCYTES IN VIVO', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, FL, Tampa, pp. 272 - 272, presented at 27th Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), FL, Tampa, 16 November 2022 - 20 November 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000888571001365&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    2020, 'Molecular underpinnings of RB status as a biomarker of poor outcome in advanced prostate cancer', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 38, presented at Genitourinary Cancers Symposium of the American-Society-of-Clinical-Oncology (ASCO), CA, San Francisco, 13 February 2020 - 15 February 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000529525900258&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2020
    2020, A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth, , http://dx.doi.org/10.1101/2020.09.02.279356
    Conference Abstracts | 2019
    2019, 'Vulnerabilities in glutamine metabolism define triple-negative from Luminal A breast cancer subsets', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 80, presented at 42nd Annual San Antonio Breast Cancer Symposium, TX, San Antonio, 09 December 2019 - 14 December 2019, http://dx.doi.org/10.1158/1538-7445.SABCS19-P3-02-09
    Conference Papers | 2018
    2018, 'Abstract 5167: Rab27a promotes melanoma cell invasion and metastasis via the regulation of exosome secretion', in Cancer Research, American Association for Cancer Research (AACR), pp. 5167 - 5167, presented at Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL, http://dx.doi.org/10.1158/1538-7445.am2018-5167
    Conference Papers | 2018
    2018, 'Abstract A036: Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. A036 - A036, presented at Abstracts: AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; December 2-5, 2017; Orlando, Florida, http://dx.doi.org/10.1158/1538-7445.prca2017-a036
    Conference Papers | 2018
    2018, 'Abstract B20: Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets', in Molecular Cancer Research, American Association for Cancer Research (AACR), pp. B20 - B20, presented at Abstracts: AACR Special Conference: Advances in Breast Cancer Research; October 7-10, 2017; Hollywood, CA, http://dx.doi.org/10.1158/1557-3125.advbc17-b20
    Conference Papers | 2017
    2017, 'Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, FL, Orlando, pp. 43 - 43, presented at AACR Special Conference on Prostate Cancer - Advances in Basic, Translational, and Clinical Research, FL, Orlando, 02 December 2017 - 05 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441803800054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2017
    2017, 'Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets.', in MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, Hollywood, pp. 72 - 72, presented at AACR Special Conference on Advances in Breast Cancer Research, CA, Hollywood, 07 October 2017 - 10 October 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440602000103&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    2016, 'Abstract 1007: The amino acid transporter SNAT4: Potential role as a tumor suppressor in melanoma', in Cancer Research, American Association for Cancer Research (AACR), pp. 1007 - 1007, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-1007
    Conference Papers | 2016
    2016, 'Abstract 1043: Targeting ASCT2-mediated glutamine uptake and metabolism in breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 1043 - 1043, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-1043
    Conference Papers | 2015
    2015, 'Inhibition of ASCT2-mediated glutamine uptake blocks prostate cancer growth', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 32 - 32, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    2015, 'PI3K/Akt signalling regulates leucine transport in prostate cancer', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 34 - 35, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    2015, 'Regulation of amino acid uptake coordinates adaptive cancer cell metabolism', in AMINO ACIDS, SPRINGER WIEN, pp. 1625 - 1625, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358175100050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    2015, 'Targeting adaptive nutrient metabolism pathways as a therapy for prostate cancer', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 47 - 47, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    2015, 'Targeting amino acid transport to block mTORC1 and cell cycle in prostate cancer', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, presented at Abstracts: AACR Special Conference: Targeting the PI3K-mTOR Network in Cancer; September 14-17, 2014; Philadelphia, PA, http://dx.doi.org/10.1158/1538-8514.PI3K14-B14
    Conference Papers | 2013
    Klein A; Hambley TW; Bierbach U; Holst J, 2013, 'Novel Amidinediaminetricarboxylato Platinum(IV)-Anthraquinone Complexes for Targeting Tumours', in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, FRANCE, Grenoble, pp. S665 - S665, presented at 16th International Conference on Biological Inorganic Chemistry (ICBIC), FRANCE, Grenoble, 22 July 2013 - 26 July 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332835300601&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Conference Papers | 2012
    Rasko J; Wong J; Ritchie W; Olivia E; Matthias S; Wong JW H; Huang Y; Gao D; Gonzalez M; Baidya K; Theong A; Khoo T-L; Bailey CG; Holst J, 2012, 'Intron Retention Coupled with Nonsense-Mediated Decay Determines Protein Expression and Nuclear Morphology in Granulopoiesis', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.112.112
    Conference Papers | 2009
    2009, 'INCORPORATING 2A PEPTIDE SEQUENCES INTO LENTIVIRAL VECTORS FOR EFFICIENT MOLECULAR IMAGING IN VIVO', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, AUSTRALIA, Sydney, pp. 845 - 846, presented at 6th Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Sydney, 29 April 2009 - 01 May 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270043300040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2002
    Holst J; Sim AT; Ludowyke RI, 2002, 'Regulation of myosin phosphorylation by protein phosphatase 2a in mast cells', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CALIFORNIA, SAN FRANCISCO, pp. 53A - 53A, presented at 42nd Annual Meeting of the American-Society-for-Cell-Biology, CALIFORNIA, SAN FRANCISCO, 14 December 2002 - 18 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179569100297&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

NHMRC/MRFF ABC Brain Cancer Grant, A new targeted combination therapy with matched biomarker to treat intractable glioblastoma. Jan 2023-Dec 2024 (CIA)

Cancer Council NSW Project Grant, Targeting the metabolic adaptations that drive anti-androgen resistance in prostate cancer. Jan 2023-Dec 2025 (CIA)

NBCF Investigator Initiated Grant, Using a physiological Ex Vivo Clinical Trial Platform to EViCT breast cancer. Jan 2023-Dec 2025 (CIA)

Tour de Cure Senior Research Grant, Developing the ultimate cancer "indoor trainer" setup to personalise cancer therapies. Jan 2023-Dec 2024 (CIA)

Charlie Teo Foundation Pilot Grant, Developing a metabolic roadmap to discover novel therapeutic avenues to starve glioblastoma. Jan 2021-Jun 2023 (CIA)

Tour de Cure Senior Research Grant, A new therapy targeting “gluttonous” prostate cancer cells Jan 2020-Dec 2020 (CIA)

Cancer Council NSW Project Grant, Targeting glutamine addiction of triple-negative breast cancer (TNBC). Jan 2018-Dec 2020 (CIA)

Cancer Council NSW Project Grant, Nutrient stress-mediated adaptive responses as novel targets in BRAF mutant melanoma. July 2017-Dec 2020 (CIA)

NHMRC/MRFF Lifting Clinical Trials and Registries Capacity Grant, Immunotherapy Targeting of Cytomegalovirus antigens in Glioblastoma: INTERROGATE-GBM. June 2018-June 2023 (CIC)

NHMRC Project Grant APP1144108 Metabolically Reprogramming the Stroma to Starve Pancreatic Tumours. Jan 2018-Dec 2020 (CID)

Avner Pancreatic Cancer Foundation, Starvation of pancreatic tumours by metabolically reprogramming both tumour and stromal cells. January 2019-December 2020 (CIC)

The Translational Cancer Metabolism Laboratory is focussed on understanding the role of amino acid uptake and metabolism in melanoma, breast and prostate cancer. The lab examines the basic biology regulating amino acid transporter expression and function, the downstream metabolic pathways, as well as developing new therapeutics to target the transporters and metabolic processes.

Key Publications:

Quek LE, van Geldermalsen M, Guan YF, Wahi K, Mayoh C, Balaban S, Pang A, Wang Q, Cowley MJ, Brown KK, Turner N, Hoy AJ, Holst J. Glutamine addiction promotes glucose oxidation in triple-negative breast cancer. Oncogene, 41(34):4066-78, 2022.

Wang Q, Guan YF, Hancock SE, Wahi K, van Geldermalsen M, Zhang BK, Pang A, Nagarajah R, Mak B, Freidman N, Horvath LG, Turner N, Holst J. Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth. The Journal of Pathology, 254(2):135-146, 2021.

Zhang BK, Moran AM, Bailey CG, Rasko JEJ, Holst J*, Wang Q*. EGF-activated PI3K/Akt signaling coordinates leucine uptake by regulating LAT3 expression in prostate cancer. Cell Communication and Signaling, 17(1):83, 2019. *=Co-Senior Author

van Geldermalsen M, Quek LE, Turner N, Freidman N, Pang A, Guan YF, Krycer JR, Ryan R, Wang Q, Holst J. Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways. BMC Cancer, 18(1):689, 2018.

Marshall AD, van Geldermalsen M, Otte NJ, Lum T, Vellozzi M, Thoeng A, Pang A, Nagarajah R, Zhang B, Wang Q, Anderson L, Rasko JEJ, Holst J. ASCT2 Regulates Glutamine Uptake and Cell Growth in Endometrial Carcinoma. Oncogenesis, 6(7):e367, 2017.

van Geldermalsen M, Wang Q, Nagarajah R, Marshall A, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, Harvey K, Beith JM, Selinger C, O’Toole S, Rasko JEJ, Holst J. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene, 35(24):3201-8, 2016.

Wang Q, Hardie R-A, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, Sadowski MC, Balaban S, Schreuder M, Nagarajah R, Wong JJ-L, Metierre C, Pinello N, Otte, NJ, Lehman ML, Gleave M, Nelson CC, Bailey CG, Ritchie W, Rasko JEJ, Holst J. Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. The Journal of Pathology 236(3):278-89, 2015. 

Wang Q, Beaumont KA, Otte NJ, Font J, Bailey CG, van Geldermalsen M, Sharp DM, Tiffen JC, Ryan RM, Jormakka M, Haass NK, Rasko JEJ, Holst J. Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer 135(5):1060-71, 2014.

Wang Q, Tiffen J, Bailey CG, Lehman ML, Ritchie W, Fazli L, Metierre C, Feng Y, Li E, Gleave M, Buchanan G, Nelson CC, Rasko JEJ and Holst J. Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth and tumor development. Journal of the National Cancer Institute. 105(19):1463-73, 2013.

Wong JJ-L, Ritchie W, Ebner OA, Selbach M, Wong JWH, Huang Y, Gao D, Pinello N, Gonzalez M, Baidya K, Thoeng A, Khoo T-L, Bailey CG, Holst J* and Rasko JEJ*Orchestrated intron retention regulates normal granulocyte differentiation. Cell. 154(3) 583-595, 2013.

Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman ML, Hendy SC, Buchanan G, Nelson CC, Rasko JEJ and Holst J. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport in prostate cancer progression. Cancer Research 71(24):7525-36, 2011

Director of Engagement and Industry Partnerships, School of Biomedical Sciences, Faculty and Medicine and Health.

My Research Supervision

Michelle Devadason (PhD student)

Aaron Khong (Honours student)

Carley Purcell (PhD student with Chaffer Lab)

Sofia Mason (PhD student with Chaffer Lab)

My Teaching

I currently teach in Pharmacology, including lectures, tutorials and practicals on cancer therapeutics for PHAR3251 and PHAR3111.