Dr Jeff Hook

Research Officer
Medicine & Health
School of Biomedical Sciences
+61 2 9385 3901
  • Journal articles | 2019
    Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9
    Journal articles | 2018
    Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR; Gunning PW; Hardeman EC, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-22946-x
    Journal articles | 2018
    Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, 131, http://dx.doi.org/10.1242/jcs.212654
    Journal articles | 2017
    Currier MA; Stehn JR; Swain A; Chen D; Hook J; Eiffe E; Heaton A; Brown D; Nartker BA; Eaves DW; Kloss N; Treutlein H; Zeng J; Alieva IB; Dugina VB; Hardeman EC; Gunning PW; Cripe TP, 2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873
    Journal articles | 2016
    Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19816
    Journal articles | 2015
    Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453
    Journal articles | 2013
    Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2011
    Hook J; Lemckert F; Schevzov G; Fath T; Gunning P, 2011, 'Functional identity of the gamma tropomyosin gene: Implications for embryonic development, reproduction and cell viability', BioArchitecture, 1, pp. 49 - 59, http://dx.doi.org/10.4161/bioa.1.1.15172
    Journal articles | 2011
    Nguyen MA; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ; North KN; Gunning PW; Mitchell CA; Hardeman EC, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.', Brain, 134, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274
    Journal articles | 2010
    Fath T; Chan Y; Vrhovski B; Clarke H; Curthoys N; Hook J; Lemckert F; Schevzov G; Tam P; Watson C; Khoo P; Gunning P, 2010, 'New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2', European Journal of Cell Biology, 89, pp. 489 - 498, http://dx.doi.org/10.1016/j.ejcb.2009.11.028
    Journal articles | 2010
    Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Tay ES; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', The Journal of Biological Chemistry, 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660
    Journal articles | 2009
    Lee AS; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D; Gunning PW; Hardeman EC, 2009, 'Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle', Stem Cells, 27, pp. 1098 - 1108, http://dx.doi.org/10.1002/stem.28
    Journal articles | 2008
    Chang AC; Hook J; Lemckert FA; McDonald M; Nguyen MA; Hardeman EC; Little DG; Gunning PW; Reddel RR, 2008, 'The murine stanniocalcin 2 gene is a negative regulator of postnatal growth', Endocrinology, 149, pp. 2403 - 2410, http://dx.doi.org/10.1210/en.2007-1219
    Journal articles | 2008
    Schevzov G; Fath T; Vrhovski B; Vlahovich N; Rajan S; Hook J; Joya JE; Lemckert F; Puttur F; Lin JJ; Hardeman EC; Wieczorek DF; O'Neill GM; Gunning PW, 2008, 'Divergent regulation of the sarcomere and the cytoskeleton', The Journal of Biological Chemistry, 283, pp. 275 - 283, http://dx.doi.org/10.1074/jbc.M704392200
    Journal articles | 2007
    MacArthur DG; Seto JT; Raftery JM; Quinlan KG; Huttley GA; Hook JW; Lemckert FA; Kee AJ; Edwards MR; Berman Y; Hardeman EC; Gunning PW; Easteal S; Yang N; North KN, 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, 39, pp. 1261 - 1265, http://dx.doi.org/10.1038/ng2122
    Journal articles | 2007
    Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, 7, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008
    Journal articles | 2004
    Hook J; Lemckert F; Qin H; Schevzov G; Gunning P, 2004, 'Gamma tropomyosin gene products are required for embryonic development', Molecular and Cellular Biology, 24, pp. 2318 - 2323, http://dx.doi.org/10.1128/MCB.24.6.2318-2323.2004
    Journal articles | 1999
    Dos Remedios NJ; Ramsland PA; Hook JW; Raison RL, 1999, 'Identification of a homologue of CD59 in a cyclostome: Implications for the evolutionary development of the complement system', Developmental and Comparative Immunology, 23, pp. 1 - 14, http://dx.doi.org/10.1016/S0145-305X(98)00049-4
    Journal articles | 1994
    Dos Remedios NJ; Hook JW; Raftos DA; Raison RL, 1994, 'D.2 Molecular cloning of a cell-surface complement receptor on hagfish leukocytes', Developmental and Comparative Immunology, 18, http://dx.doi.org/10.1016/0145-305X(94)90094-9
    Journal articles | 1994
    RAISON RL; COVERLEY J; HOOK JW; TOWNS P; WESTON KM; RAFTOS DA, 1994, 'A cell‐surface opsonic receptor on leucocytes from the phylogenetically primitive vertebrate, Eptatretus stouti', Immunology and Cell Biology, 72, pp. 326 - 332, http://dx.doi.org/10.1111/j.1440-1711.1994.tb03797.x
    Journal articles | 1994
    Raison RL; Hook J; Coverley J; Newton R; Geczy C; Raftos D, 1994, 'D.1 Humoral immunity in the agnatha: The role of complement-like proteins', Developmental and Comparative Immunology, 18, http://dx.doi.org/10.1016/0145-305X(94)90093-0
    Journal articles | 1992
    Hanley PJ; Hook JW; Raftos DA; Gooley AA; Trent R; Raison RL, 1992, 'Hagfish humoral defense protein exhibits structural and functional homology with mammalian complement components', Proceedings of the National Academy of Sciences of the United States of America, 89, pp. 7910 - 7914, http://dx.doi.org/10.1073/pnas.89.17.7910
    Journal articles | 1992
    Raftos DA; Hook JW; Raison RL, 1992, 'Complement-like protein from the phylogenetically primitive vertebrate,Eptatretus Stouti, is a Humoral Opsonin', Comparative Biochemistry and Physiology -- Part B: Biochemistry and, 103, pp. 379 - 384, http://dx.doi.org/10.1016/0305-0491(92)90308-E
    Journal articles | 1990
    Hanley PJ; Seppelt IM; Gooley AA; Hook JW; Raison RL, 1990, 'Distinct Ig H chains in a primitive vertebrate, Eptatretus stouti', Journal of Immunology, 145, pp. 3823 - 3828
  • Conference Posters | 2016
    Stehn J; Mariana A; Failes T; Ashokakumar V; Eiffe E; Heaton A; Hook J; Sivanandhan D; Arndt G; Gunning P; Brown D, 2016, 'Synergistic action of first-in-class anti-tropomyosin compound, ATM-3507 (Anisina) and microtubule targeting inhibitors in pre-clinical models of non-small cell lung cancer (NSCLC)', GERMANY, Munich, Vol. 69, pp. S116 - S116, presented at 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, GERMANY, Munich, 29 November 2016 - 02 December 2016, http://dx.doi.org/10.1016/S0959-8049(16)32946-X
    Conference Abstracts | 2015
    Stehn J; Currier M; Chen D; Eiffe E; Heaton A; Hook J; Gunning P; Cripe T, 2015, 'First-in-class cytoskeletal targeting drug, Anisina, enhances effectiveness of microtubule inhibitors in a preclinical model of neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, FL, Fort Lauderdale, Vol. 76, presented at AACR Special Conference on Advances in Pediatric Cancer Research - From Mechanisms and Models to Treatment and Survivorship, FL, Fort Lauderdale, 09 November 2015 - 12 November 2015, http://dx.doi.org/10.1158/1538-7445.PEDCA15-B27
    Conference Presentations | 2014
    Schevzov G; Wang B; Hook JW; Tonthat C; Pleines I; Kile B; Hardeman EC; Gunning PW, 2014, 'Distinct Actin Filament Networks Modulate Different Cell Signalling Pathways Involved in Cell Proliferation and Senescence.', Vol. 25, presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Schevzov G; Wang B; Hook JW; Tonthat C; Pleines I; Kile B; Hardeman EC; Gunning PW, 2014, 'Distinct Actin Filament Networks Modulate Different Cell Signalling Pathways Involved in Cell Proliferation and Senescence.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094106093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2006
    Yang N; MacArthur DG; Kee AJ; Kettle E; Hardeman EC; Lemckert F; Hook J; Gunning PW; North KN, 2006, 'An alpha -actinin-3 Knockout Mouse Suffers Increased Sarcomeric Damage from Eccentric Exercise', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, pp. S123 - S124, http://dx.doi.org/10.1249/00005768-200605001-01445
    Conference Papers | 2004
    Gunning P; Schevzov G; Vrhovski B; Hook J; Lemckert F; Weinberger R; Hardemann E, 2004, 'Tropomyosins regulate neuronal shape and dimension', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, DC, Washington, pp. 48A - 49A, presented at Annual Meeting of the American-Society-for-Cell-Biology, DC, Washington, 04 December 2004 - 08 December 2004, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224648800270&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1