Dr Jeremy Henson

Dr Jeremy Henson

Adjunct Senior Lecturer
Science
School of Biotech & Biomolecular Science

Dr Henson’s first scientific interest was theoretical physics and he initially chose a university degree that allowed him to study both theoretical physics and medicine. In his first year at university he developed a fascination with cellular mortality/immortality mechanisms. Dr Henson graduated from UNSW in 1998 with an MBBS and a BSc that included two honours degrees (Pure Mathematics and Molecular Biology) and four majors. During this time he was also self-author/publisher, of the Don’t Panic study guide that sold over 10,000 copies. Since graduating, Dr Henson he has worked as a clinician for 15 years, and has been a Career Medical Officer at Westmead Private Hospital since 2005. In 2007, Dr Henson completed his PhD on the ALT cancer immortality mechanism at the University of Sydney School of Medicine, and worked as a post-doctoral fellow at the Children’s Medical Research Institute for 7 years, where he correctly predicted the presence of a completely novel type of biomarker for the ALT immortality mechanism and invented the only quantitative assay for ALT cancer activity. Dr Henson now leads the Cancer Cell Immortality group in the Adult Cancer Program, Prince of Wales Clinical School, UNSW Medicine, which is generating novel cancer therapeutics and diagnostics based on Dr Henson’s discoveries. Dr Henson is a member of the Translational Cancer Research Network. 

Phone
02 9385 3205
Location
Level 2, Lowy Cancer Research Centre C25 UNSW Australia UNSW Sydney NSW 2052 Australia
  • Book Chapters | 2009
    Jiang W-Q; Henson JD; Axel AN; Roger RR, 2009, 'Protocol III: Detection of Alternative Lengthening of Telomeres', in Telomeres and Telomerase in Cancer, Humana Press, pp. 351 - 364, http://dx.doi.org/10.1007/978-1-60327-879-9_16
  • Journal articles | 2023
    Vitetta L; Gorgani NN; Vitetta G; Henson JD, 2023, 'Prebiotics Progress Shifts in the Intestinal Microbiome That Benefits Patients with Type 2 Diabetes Mellitus', Biomolecules, 13, pp. 1307 - 1307, http://dx.doi.org/10.3390/biom13091307
    Journal articles | 2022
    Chen J; Vitetta L; Henson JD; Hall S, 2022, 'Intestinal Dysbiosis, the Tryptophan Pathway and Nonalcoholic Steatohepatitis', International Journal of Tryptophan Research, 15, http://dx.doi.org/10.1177/11786469211070533
    Journal articles | 2022
    Clarke S; Butcher BE; McLachlan AJ; Henson JD; Rutolo D; Hall S; Vitetta L, 2022, 'Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain', PLoS ONE, 17, http://dx.doi.org/10.1371/journal.pone.0270543
    Journal articles | 2022
    Henson JD; Vitetta L; Hall S, 2022, 'Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions', Inflammopharmacology, 30, pp. 1167 - 1178, http://dx.doi.org/10.1007/s10787-022-01020-z
    Journal articles | 2022
    Vitetta L; Andersen T; Quezada M; Rutolo D; Henson JD, 2022, 'Re: "Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial" by Crippa et al.', Cannabis and Cannabinoid Research, 7, pp. 231 - 233, http://dx.doi.org/10.1089/can.2022.0034
    Journal articles | 2022
    Vitetta L; Sikali JF; Fletcher C; Henson JD, 2022, 'Comment on: Cannabis use among Danish patients with cancer: a cross‑sectional survey of sociodemographic traits, quality of life, and patient experiences', Supportive Care in Cancer, http://dx.doi.org/10.1007/s00520-022-06995-7
    Journal articles | 2021
    Chen J; Vitetta L; Henson JD; Hall S, 2021, 'The intestinal microbiota and improving the efficacy of COVID-19 vaccinations', Journal of Functional Foods, 87, http://dx.doi.org/10.1016/j.jff.2021.104850
    Journal articles | 2021
    Chen YY; Dagg R; Zhang Y; Lee JHY; Lu R; La Rotta NM; Sampl S; Korkut-Demirbaş M; Holzmann K; Lau LMS; Reddel RR; Henson JD, 2021, 'The c-circle biomarker is secreted by alternative-lengthening-of-telomeres positive cancer cells inside exosomes and provides a blood-based diagnostic for alt activity', Cancers, 13, http://dx.doi.org/10.3390/cancers13215369
    Journal articles | 2021
    Henson JD; Vitetta L; Quezada M; Hall S, 2021, 'Enhancing endocannabinoid control of stress with cannabidiol', Journal of Clinical Medicine, 10, pp. 5852 - 5852, http://dx.doi.org/10.3390/jcm10245852
    Journal articles | 2021
    Kaul Z; Cheung CTY; Bhargava P; Sari AN; Yu Y; Huifu H; Bid H; Henson JD; Groden J; Reddel RR; Kaul SC; Wadhwa R, 2021, 'Functional characterization of miR-708 microRNA in telomerase positive and negative human cancer cells', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-96096-y
    Journal articles | 2021
    Vitetta L; Butcher B; Henson JD; Rutolo D; Hall S, 2021, 'A pilot safety, tolerability and pharmacokinetic study of an oro-buccal administered cannabidiol-dominant anti-inflammatory formulation in healthy individuals: a randomized placebo-controlled single-blinded study', Inflammopharmacology, 29, pp. 1361 - 1370, http://dx.doi.org/10.1007/s10787-021-00859-y
    Journal articles | 2020
    Clarke SJ; Vitetta L; McLachlan AJ; Henson JD; Rutolo D; Hall S, 2020, 'An oro-buccal nanoparticle delivered cannabis medicine for pain management in cancer: A clinical trial in progress.', Journal of Clinical Oncology, 38, pp. TPS12127 - TPS12127, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.tps12127
    Journal articles | 2020
    Vitetta L; Henson JD, 2020, 'Probiotics and synbiotics targeting the intestinal microbiome attenuate non-alcoholic fatty liver disease.', Hepatobiliary Surg Nutr, 9, pp. 526 - 529, http://dx.doi.org/10.21037/hbsn.2019.11.24
    Journal articles | 2018
    Noor H; Rapkins R; Henson J; McDonald K, 2018, 'CBMT-45. A NOVEL C-CIRCLE ASSAY FOR DETECTING ALTERNATIVE LENGTHENING OF TELOMERES (ALT) MECHANISMS', Neuro-Oncology, 20, pp. vi42 - vi42, http://dx.doi.org/10.1093/neuonc/noy148.164
    Journal articles | 2018
    Udugama M; Sanij E; Voon HPJ; Son J; Hii L; Henson JD; Lyn Chan F; Chang FTM; Liu Y; Pearson RB; Kalitsis P; Mann JR; Collas P; Hannan RD; Wong LH, 2018, 'Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4737 - 4742, http://dx.doi.org/10.1073/pnas.1720391115
    Journal articles | 2017
    Dagg RA; Pickett HA; Neumann AA; Napier CE; Henson JD; Teber ET; Arthur JW; Reynolds CP; Murray J; Haber M; Sobinoff AP; Lau LMS; Reddel RR, 2017, 'Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres', Cell Reports, 19, pp. 2544 - 2556, http://dx.doi.org/10.1016/j.celrep.2017.05.087
    Journal articles | 2017
    Henson JD; Lau LM; Koch S; Martin La Rotta N; Dagg RA; Reddel RR, 2017, 'The C-Circle Assay for alternative-lengthening-of-telomeres activity', Methods, 114, pp. 74 - 84, http://dx.doi.org/10.1016/j.ymeth.2016.08.016
    Journal articles | 2017
    Sobinoff AP; Allen JAM; Neumann AA; Yang SF; Walsh ME; Henson JD; Reddel RR; Pickett HA, 2017, 'BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres', EMBO Journal, 36, pp. 2907 - 2919, http://dx.doi.org/10.15252/embj.201796889
    Journal articles | 2015
    Silva H; Halvorsen D; Henson JD, 2015, 'Control ALT, delete cancer', Scientist, 29
    Journal articles | 2014
    Reddel R; Conomos D; Henson J; Napier C; Neumann A; Pickett H, 2014, 'Non‐telomerase telomere maintenance in human cells (97.2)', The FASEB Journal, 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.97.2
    Journal articles | 2013
    Lau LMS; Dagg RA; Henson JD; Au AYM; Royds JA; Reddel RR, 2013, 'Detection of alternative lengthening of telomeres by telomere quantitative PCR', Nucleic Acids Research, 41, http://dx.doi.org/10.1093/nar/gks781
    Journal articles | 2011
    Pickett HA; Henson JD; Au AYM; Neumann AA; Reddel RR, 2011, 'Normal mammalian cells negatively regulate telomere length by telomere trimming', Human Molecular Genetics, 20, pp. 4684 - 4692, http://dx.doi.org/10.1093/hmg/ddr402
    Journal articles | 2010
    Henson JD; Reddel RR, 2010, 'Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers', FEBS Letters, 584, pp. 3800 - 3811, http://dx.doi.org/10.1016/j.febslet.2010.06.009
    Journal articles | 2010
    Henson JD, 2010, 'For cancers there is more to life than a longer G-strand', Asian Journal of Andrology, 12, pp. 779 - 782, http://dx.doi.org/10.1038/aja.2010.103
    Journal articles | 2010
    McDonald KL; McDonnell J; Muntoni A; Henson JD; Hegi ME; Von Deimling A; Wheeler HR; Cook RJ; Biggs MT; Little NS; Robinson BG; Reddel RR; Royds JA, 2010, 'Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival', Journal of Neuropathology and Experimental Neurology, 69, pp. 729 - 736, http://dx.doi.org/10.1097/NEN.0b013e3181e576cf
    Journal articles | 2009
    Henson JD; Cao Y; Huschtscha LI; Chang AC; Au AYM; Pickett HA; Reddel RR, 2009, 'DNA C-circles are specific and quantifiable markers of alternative- lengthening-of-telomeres activity', Nature Biotechnology, 27, pp. 1181 - 1185, http://dx.doi.org/10.1038/nbt.1587
    Journal articles | 2009
    Jiang WQ; Zhong ZH; Nguyen A; Henson JD; Toouli CD; Braithwaite AW; Reddel RR, 2009, 'Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins', Journal of Cell Biology, 185, pp. 797 - 810, http://dx.doi.org/10.1083/jcb.200810084
    Journal articles | 2006
    Costa A; Daidone MG; Daprai L; Villa R; Cantù S; Pilotti S; Mariani L; Gronchi A; Henson JD; Reddel RR; Zaffaroni N, 2006, 'Telomere maintenance mechanisms in liposarcomas: Association with histologic subtypes and disease progression', Cancer Research, 66, pp. 8918 - 8924, http://dx.doi.org/10.1158/0008-5472.CAN-06-0273
    Journal articles | 2005
    Henson JD; Hannay JA; McCarthy SW; Royds JA; Yeager TR; Robinson RA; Wharton SB; Jellinek DA; Arbuckle SM; Yoo J; Robinson BG; Learoyd DL; Stalley PD; Bonar SF; Yu D; Pollock RE; Reddel RR, 2005, 'A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas', Clinical Cancer Research, 11, pp. 217 - 225
    Journal articles | 2005
    Jeyapalan JN; Varley H; Foxon JL; Pollock RE; Jeffreys AJ; Henson JD; Reddel RR; Royle NJ, 2005, 'Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome', Human Molecular Genetics, 14, pp. 1785 - 1794, http://dx.doi.org/10.1093/hmg/ddi185
    Journal articles | 2005
    Jiang WQ; Zhong ZH; Henson JD; Neumann AA; Chang ACM; Reddel RR, 2005, 'Erratum: Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex (Molecular and Cellular Biology (2005) 25:7 (2708-2721))', Molecular and Cellular Biology, 25, pp. 4334, http://dx.doi.org/10.1128/MCB.25.10.4334.2005
    Journal articles | 2005
    Jiang WQ; Zhong ZH; Henson JD; Neumann AA; Chang ACM; Reddel RR, 2005, 'Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex', Molecular and Cellular Biology, 25, pp. 2708 - 2721, http://dx.doi.org/10.1128/MCB.25.7.2708-2721.2005
    Journal articles | 2002
    Henson JD; Neumann AA; Yeager TR; Reddel RR, 2002, 'Alternative lengthening of telomeres in mammalian cells', Oncogene, 21, pp. 598 - 610, http://dx.doi.org/10.1038/sj/onc/1205058
  • Preprints | 2020
    Clarke S; Butcher B; McLachlan A; Henson J; Rutolo D; Hall S; Vitetta L, 2020, Pilot Clinical and Pharmacokinetic Study of Δ9-Tetrahydrocannabinol and Cannabidiol Oro-Buccal Spray in Advanced Cancer with Uncontrolled Pain., , http://dx.doi.org/10.22541/au.159969847.76735495
    Conference Papers | 2020
    Clarke S; Butcher B; McLachlan AJ; Henson JD; Rutolo D; Hall S; Vitetta L, 2020, 'Pilot clinical and pharmacokinetic study of a water soluble nanoparticle cannabis-based medicine in advanced cancer with intractable pain', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 117 - 118, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000790145400136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Malykh AG; Doyle JR; Tian F; Lee JHY; Henson JD; Reddel RR, 2015, 'Identification of new alternative lengthening of telomeres (ALT)-positive cancer cell lines using the C-circle assay', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 75, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-3768
    Conference Abstracts | 2014
    Gupta R; Dong Y; Solomon PD; Wettersten HI; Cheng CJ; Min JN; Henson J; Dogra SK; Hwang SH; Hammock BD; Zhu LJ; Reddel RR; Saltzman WM; Weiss RH; Chang S; Green MR; Wajapeyee N, 2014, 'Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A', in Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, http://dx.doi.org/10.1073/pnas.1411370111
    Conference Abstracts | 2014
    Lee JH; Reddel RR; Henson JD, 2014, 'THE C-CIRCLE ASSAY AS A BLOOD TEST FOR ALT CANCER ACTIVITY', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 10, pp. 12 - 12, http://dx.doi.org/10.1111/ajco.12284
    Conference Papers | 2014
    Reddel R; Conomos D; Henson J; Napier C; Neumann A; Pickett H, 2014, 'Non-telomerase telomere maintenance in human cells', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 26 April 2014 - 30 April 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346646705193&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Sampl S; Hadolt J; Kienzl P; Braunschmid T; Stättner S; Henson JD; Reddel RR; Marian B; Holzmann K, 2012, 'Abstract 4597: Telomere maintenance mechanism and expression in colorectal cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 4597 - 4597, presented at Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL, http://dx.doi.org/10.1158/1538-7445.am2012-4597
    Conference Abstracts | 2010
    McDonald K; McDonnell J; Muntoni A; Henson J; Hegi M; Wheeler H; Cook R; Biggs M; Little N; Robinson B; Jellinek D; Reddel R; Royds J, 2010, 'LONGER SURVIVAL FOR PATIENTS WITH ALTERNATIVE LENGTHENING OF TELOMERES (ALT) GLIOBLASTOMA MULTIFORME IS DUE TO A LESS AGGRESSIVE PHENOTYPE AND NOT TO IMPROVED RESPONSE TO ADJUVANT THERAPY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, SCOTLAND, Glasgow, Vol. 12, pp. 3 - 3, presented at Meeting of the British-Neuro-Oncology-Society, SCOTLAND, Glasgow, 23 June 2010 - 25 June 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279583000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2009
    McDonald KL; McDonnell J; Henson J; Muntoni A; Wheeler HR; Robinson BG; Reddel RR; Royds J, 2009, 'PRESENCE OF AN ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM AS A FAVORABLE PROGNOSTIC MARKER IN PATIENTS WITH GLIOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, JAPAN, Yokohama, Vol. 11, pp. 897 - 897, presented at 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology, JAPAN, Yokohama, 11 May 2009 - 14 May 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272974100111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2009
    McDonald KL; McDonnell J; Henson J; Muntoni A; Wheeler HR; Robinson BG; Reddel RR; Royds J, 2009, 'PRESENCE OF AN ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM AS A FAVORABLE PROGNOSTIC MARKER IN PATIENTS WITH GLIOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, JAPAN, Yokohama, Vol. 11, pp. 928 - 928, presented at 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology, JAPAN, Yokohama, 11 May 2009 - 14 May 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272974100244&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2007
    Jiang WQ; Zhong ZH; Henson JD; Reddel RR, 2007, 'Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference', in Oncogene, Vol. 26, pp. 4635 - 4647, http://dx.doi.org/10.1038/sj.onc.1210260