Dr Jia (Jenny) Liu

Dr Jia (Jenny) Liu

Conjoint Senior Lecturer

BSc(Med) Hons (Class1), BMed (Dist), MD (Dist, University Medal) PhD FRACP                                           

Medicine & Health
School of Clinical Medicine

As the Translational Lead of Early Phase Drug Development at The Kinghorn Cancer Centre, I oversee and manage the design and execution of clinical trials for novel cancer therapeutics, with a focus on early phase drug development, investigator-led studies, and head and neck cancer. I have over 10 years of experience in oncology research and practice, and hold an MD, a PhD in Oncology and Cancer Biology, and a Fellowship of the Royal Australasian College of Physicians (FRACP).

My mission is to advance the understanding and treatment of cancer by applying cutting-edge proteomics technologies and biomarker discovery methods to rationally designed, patient-centric early phase trials. I collaborate with leading researchers and institutions nationally and internationally, such as the Garvan Institute and the Children's Medical Research Institute, as well as international drug development consortia, to identify molecular signatures and pathways that predict response and outcome in various cancer cohorts. I also have active research interests in supportive care, such as developing interventions to address fear of cancer recurrence in cancer survivors.  

Phone
040/553-6859
Location
Darlinghurst, NSW
  • Journal articles | 2024
    Boys EL; Gao B; Grimison P; Sutherland S; MacKenzie KL; Reddel RR; Liu J, 2024, 'Retrospective analysis of clinical characteristics and outcomes of patients with carcinoma of unknown primary from three tertiary centers in Australia', Cancer Medicine, 13, pp. e7052 - e7052, http://dx.doi.org/10.1002/cam4.7052
    Journal articles | 2024
    Nindra U; Shivasabesan G; Mellor R; Chua W; Ng W; Karikios D; Richards B; Liu J, 2024, 'Evaluating Systemic Burnout in Medical Oncology Through a National Oncology Mentorship Program', JCO Oncology Practice, 20, pp. 549 - 557, http://dx.doi.org/10.1200/OP.23.00469
    Journal articles | 2024
    Pham JP; Rodrigues A; Goldinger SM; Sim H-W; Liu JJ, 2024, 'Epidermal growth factor receptor inhibitors in advanced cutaneous squamous cell carcinoma: A systematic review and meta-analysis', Experimental Dermatology, 33, http://dx.doi.org/10.1111/exd.14978
    Journal articles | 2024
    Pham JP; Zdanska O; Selga M; Javier J; O'Grady A; Chin V; Forstner D; Hsu E; Liu J, 2024, 'Oncolytic viruses to augment PD-1 inhibition in metastatic cutaneous squamous cell carcinoma', JDDG - Journal of the German Society of Dermatology, 22, pp. 1016 - 1018, http://dx.doi.org/10.1111/ddg.15423
    Journal articles | 2023
    Boys EL; Liu J; Robinson PJ; Reddel RR, 2023, 'Clinical applications of mass spectrometry‐based proteomics in cancer: Where are we?', PROTEOMICS, 23, pp. e2200238 - e2200238, http://dx.doi.org/10.1002/pmic.202200238
    Journal articles | 2023
    Liu J; He S; Butow P; Shaw J; McHardy CJ; Harris G; Serafimovska A; Butt Z; Beith J, 2023, 'A novel clinician-delivered intervention to reduce fear of recurrence in breast cancer survivors: Results from a Phase I/II implementation study (CIFeR_2).', Psychooncology, 32, pp. 1930 - 1938, http://dx.doi.org/10.1002/pon.6249
    Journal articles | 2023
    Liu J; Serafimovska A; He S; Butow P; Shaw J; McHardy CJ; Harris G; Butt Z; Beith J, 2023, 'Protocol of an implementation study of a clinician intervention to reduce fear of recurrence in cancer survivors (CIFeR_2 implementation study).', BMC Med Educ, 23, pp. 312, http://dx.doi.org/10.1186/s12909-023-04279-0
    Journal articles | 2023
    Liu JJ; He S; Butow P; Shaw J; McHardy CJ; Harris G; Serafimovska A; Butt Z; Beith JM, 2023, 'Implementation study of a novel brief clinician intervention to reduce fear of recurrence in cancer survivors (CIFeR_2 Implementation Study).', Journal of Clinical Oncology, 41, pp. e24183 - e24183, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e24183
    Journal articles | 2023
    Nindra U; Hurwitz J; Forstner D; Chin V; Gallagher R; Liu J, 2023, 'A systematic review of neoadjuvant and definitive immunotherapy in locally advanced head and neck squamous cell carcinoma', Cancer Medicine, 12, pp. 11234 - 11247, http://dx.doi.org/10.1002/cam4.5815
    Journal articles | 2023
    Pham JP; Sivasubramaniam V; Gallagher R; Forstner D; Wong M; Liu J, 2023, 'Safety of cemiplimab for advanced cutaneous squamous cell carcinoma in a patient with p-ANCA-associated vasculitis', Journal of the European Academy of Dermatology and Venereology, 37, pp. e363 - e365, http://dx.doi.org/10.1111/jdv.18649
    Journal articles | 2022
    Cai Z; Poulos RC; Liu J; Zhong Q, 2022, 'Machine learning for multi-omics data integration in cancer', iScience, 25, pp. 103798 - 103798, http://dx.doi.org/10.1016/j.isci.2022.103798
    Journal articles | 2021
    Liu J; Butow P; Bui KT; Serafimovska A; Costa DSJ; Kiely BE; Hui MN; Goodwin A; McNeil CM; Beith JM, 2021, 'Novel Clinician-Lead Intervention to Address Fear of Cancer Recurrence in Breast Cancer Survivors', JCO Oncology Practice, 17, pp. E774 - E784, http://dx.doi.org/10.1200/OP.20.00799
    Journal articles | 2021
    Serafimovska A; Liu J; Beith J; Butow P, 2021, 'Patients’ and oncologists’ perspectives on a novel Clinician-led Fear of Cancer Recurrence (CIFeR) Intervention', Supportive Care in Cancer, 29, pp. 7637 - 7646, http://dx.doi.org/10.1007/s00520-021-06336-0
    Journal articles | 2020
    Liu J; Bui KT; Serafimovska A; Kiely BE; Hui MN; Goodwin A; McNeil CM; Costa DSJ; Butow P; Beith JM, 2020, 'CIFeR: A novel Clinician-lead Intervention to address Fear of cancer Recurrence (FCR) in breast cancer survivors.', Journal of Clinical Oncology, 38, pp. 12115 - 12115, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.12115
    Journal articles | 2020
    Liu J; Goel S; Beith JMN, 2020, 'Trastuzumab-related cardiotoxicity: What do we know in 2020?', Translational Cancer Research, 9, pp. 4052 - 4055, http://dx.doi.org/10.21037/tcr-20-2188
    Journal articles | 2020
    Liu J; Wong K; Patanjali N; Boyer M; Kao S, 2020, 'Case of post-progression prolongation of survival after cessation of pembrolizumab in advanced non-small-cell lung cancer', INTERNAL MEDICINE JOURNAL, 50, pp. 771 - 773, http://dx.doi.org/10.1111/imj.14852
    Journal articles | 2019
    Goel S; Liu J; Guo H; Barry W; Bell R; Murray B; Lynch J; Bastick P; Chantrill L; Kiely BE; Abdi E; Rutovitz J; Asghari R; Sullivan A; Harrison M; Kohonen-Corish M; Beith J, 2019, 'Decline in Left Ventricular Ejection Fraction Following Anthracyclines Predicts Trastuzumab Cardiotoxicity', JACC: Heart Failure, 7, pp. 795 - 804, http://dx.doi.org/10.1016/j.jchf.2019.04.014
    Journal articles | 2019
    Liu J; Butow P; Beith J, 2019, 'Systematic review of interventions by non-mental health specialists for managing fear of cancer recurrence in adult cancer survivors', Supportive Care in Cancer, 27, pp. 4055 - 4067, http://dx.doi.org/10.1007/s00520-019-04979-8
    Journal articles | 2017
    Crabtree N; Mo S; Ong L; Jegathees T; Wei D; Fahey D; Liu JJ, 2017, 'Retrospective Analysis of Patient Presentations at the Sydney (Australia) Royal Easter Show from 2012 to 2014', Prehospital and Disaster Medicine, 32, pp. 187 - 194, http://dx.doi.org/10.1017/S1049023X16001540
    Journal articles | 2016
    Liu J; Hau E; Links M; Graham PH, 2016, 'Adenoid cystic carcinoma of the lung: Response to tamoxifen after chemoradiation', Asia-Pacific Journal of Clinical Oncology, 12, pp. e352 - e355, http://dx.doi.org/10.1111/ajco.12184
    Journal articles | 2016
    Liu J; Ng D; Lee J; Stalley P; Hong A, 2016, 'Chest wall desmoid tumours treated with definitive radiotherapy: A plan comparison of 3D conformal radiotherapy, intensity-modulated radiotherapy and volumetric-modulated arc radiotherapy', Radiation Oncology, 11, http://dx.doi.org/10.1186/s13014-016-0611-0
    Journal articles | 2016
    Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
    Journal articles | 2016
    Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M; Liu JJ, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936, http://dx.doi.org/10.4103/1008-682X.163190
    Journal articles | 2015
    Liu J; Zhang M; Rose B; Veillard AS; Jones D; Zhang X; Soon Lee C; Milross C; Hong A, 2015, 'Ki67 Expression has Prognostic Significance in Relation to Human Papillomavirus Status in Oropharyngeal Squamous Cell Carcinoma', Annals of Surgical Oncology, 22, pp. 1893 - 1900, http://dx.doi.org/10.1245/s10434-014-4237-x
    Journal articles | 2014
    Simar D; Versteyhe S; Donkin I; Liu J; Hesson L; Nylander V; Fossum A; Barres R, 2014, 'DNA Methylation Is Altered In B And NK Lymphocytes In Obese And Type 2 Diabetic Human', Metabolism: clinical and experimental, 63, pp. 1188 - 1197, http://dx.doi.org/10.1016/j.metabol.2014.05.014
    Journal articles | 2013
    Hesson LB; Patil V; Sloane MA; Nunez AC; Liu J; Pimanda JE; Ward RL, 2013, 'Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003636
    Journal articles | 2013
    Liu J; Hesson LB; Ward RL, 2013, 'Liquid chromatography tandem mass spectrometry for the measurement of global DNA methylation and hydroxymethylation', Journal of Proteomics & Bioinformatics, 01, http://dx.doi.org/10.4172/jpb.S2-005
    Journal articles | 2012
    Liu J; Hesson L; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', CANCER PREVENTION RESEARCH, 5, pp. 921 - 929, http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577
    Journal articles | 2011
    Liu J; Pickford R; Meagher AP; Ward RL, 2011, 'Quantitative analysis of tissue folate using ultra-high performance liquid chromatography tandem mass spectrometry', Analytical Biochemistry, 411, pp. 210 - 217, http://dx.doi.org/10.1016/j.ab.2010.12.033
    Journal articles | 2011
    Liu JJ; Hesson LB; Rand KN; Molloy PL; Pimanda J; Ward RL, 2011, 'Analysis of global and repeat sequence DNA methylation in the blood and normal colonic mucosa of colorectal cancer patients, healthy individuals and patients with folate deficiency', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-91
    Journal articles | 2010
    Liu J; Ward RL, 2010, 'Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer', Advances in Genetics, 71, pp. 80 - 121, http://dx.doi.org/10.1016/B978-0-12-380864-6.00004-3
  • Conference Abstracts | 2022
    Hurwitz J; Nindra U; Liu J, 2022, 'Systematic review of neoadjuvant and definitive immunotherapy in head and neck squamous cell carcinoma', in Asia-Pacific Journal of Clinical Oncology, Wiley, Vol. 18, pp. 38 - 38, presented at Medical Oncology Group of Australia Incorporated Annual Scientific Meeting 2022, https://doi.org/10.1111/ajco.13856
    Conference Abstracts | 2014
    Liu JJ; Zhang M; Rose B; Veillard A-S; Jones D; Lee S; Hong A, 2014, 'KI67 EXPRESSION HAS PROGNOSTIC SIGNIFICANCE IN RELATION TO HUMAN PAPILLOMAVIRUS STATUS IN OROPHARYNGEAL SQUAMOUS CELL CARCINOMA', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 10, pp. 180 - 181, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345350900317&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Peng J; Liu JJ; Daniels B; Firriolo J; Laaksonen MA; Hawkins NJ; Meagher AP; Hayes I; Croxford M; Cai S; Ward RL, 2014, 'RETROSPECTIVE COMPARISON OF RECTAL CANCER TREATMENT IN CHINA AND AUSTRALIA FROM 1995-2012', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345350900095&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2012
    Liu J; Hesson LB; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-3125

2022

Best of the best young researcher Award

Medical Oncology Group of Australia

2018

Runner Up, NSW Trainee Research Awards

Royal Australian College of Physicians

2018

Best Poster by Trainee Award

Medical Oncology Group of Australia

2018

Rob Sutherland Travel Grant

Sydney Catalyst

2015

Travel Award and Scholarship for RANZCR Conference

Chris O’Brien Lifehouse

2015

Travel Award and Scholarship for Basic Sciences of Oncology Course

UNSW

2014

RPA Patron’s Prize Finalist

Royal Prince Alfred Hospital

2013

University Medal (Medicine)

UNSW

2013

The Frank Rundle Prize for Surgery in Years 5-6      

UNSW

2013

The Prize for Phase 3 (Years 5-6) Portfolio

UNSW

2013

The Australian Medical Association Prize for General Practice

UNSW

2013

John Coleman Prize for Surgery

Prince of Wales Clinical School, UNSW

2013

Graham McDonald Prize for Medicine

Prince of Wales Clinical School, UNSW

2013

Max Thorpe Prize Best Overall Performance    

Prince of Wales Clinical School, UNSW

2012

Dean's List Award for Outstanding Contribution to Medical Research   

UNSW

2011

Oral Presentation Winner

Open Senior Division, Coast Association TOW Research Awards, UNSW

2011

Winner – UNSW 3 Minute Thesis Competition

UNSW

2011

Oral Presentation Winner

International Conference on Science of Nutrition in Medicine and Healthcare

2011

NHMRC Student Research Competition

Australian Medical Student’s Association Convention

2010

Oral Presentation Winner

Australian Epigenetics Alliance

2010

Poster Prize Winner

Coast Association TOW Research Awards, UNSW

2009

Poster Prize

St Vincent’s and Mater Health Research Symposium

2008

Prize for Best Overall Performance in Years 3-4 Medicine

UNSW

2008

Prize for Best Performance Written Exam in Years 3-4 Medicine

UNSW

2006

Prize for Best Overall Performance in Years 1-2 Medicine

UNSW

2005

Prize for Best Performance in First Year Medicine

UNSW

2005-08

Scholar Award

UNSW

  • early phase clinical trials leadership (investigator on >30 early phase trials) including multiple investigator-led studies in collaboration with NSW Early Phase Trials Network (NECTA) and research institutes (Garvan Institute)
  • quantitative proteomics as prognostic and predictive biomarkers, for identification of cancers of unknown primary and as biomarkers for drug development
  • clinician intervention to address fear of recurrence (CIFeR) in cancer survivors 
  • mentorship programs and their impact on clinician wellbeing, burnout and professional fulfilment

My Research Supervision

Fear of cancer recurrence in advanced cancer patients: adaption of CIFeR intervention

Epigenetic therapies to resensitise prostate cancer to androgen deprivation therapy

Proteomics in identifying cancers of unknown primary and biomarkers for novel cancer therapeutics

Regional/rural access to early phase clinical trials utilising decentralised clinical trial models

Exercise interventions in patients receiving cancer therapy

 

 

My Teaching

University of NSW Medicine Undergraduate (tutorials, vivas, examination assessments)

Basic Physician Trainees (oncology department supervisor for BPTs rotating to St Vincent's Hospital oncology term)

Former Chair of Medical Oncology AT Trainee Program NSW (2021-2023)

Supervisor and mentor to oncology trainees and early phase drug development fellows