Dr Jian Qi

Dr Jian Qi

Conjoint Senior Lecturer
Medicine & Health
School of Clinical Medicine

Dr Jian Cheng Qi is a Conjoint Senior Lecturer at the St George and Sutherland Clinical School, Faculty of Medicine. He is undertaking his research under the supervision of Conjoint Professor Steven Krilis, Head of the Department of Infectious Disease, Immunology, and Sexual Health at UNSW, a Consultant in Infectious Disease and Immunology at St George Hospital and a world-renowned expert in the biology of beta-2 glycoprotein and antiphospholipid syndrome. 

Research Interests:

His research aims are focussed on autoimmune disease and mast cell biology. His works are involved the assessment of Beta 2-glycoprotein I function in the antiphospholipid syndrome, lipid metabolism and cardiovascular disease utilising beta 2-GPI knockout mice. The 2nd area is involved with identifying the receptor on mast cells for IL-16 and the role of mast cells and basophils in inflammation, asthma and HIV-1 infection.

Broad Research Areas:

Infectious Diseases, Immunology, Haematology, Inflammation, Vascular biology and Autoimmunity

Qualifications: PhD (medicine)

Specific Research Keywords:

Infectious disease, oxidative stress, beta 2-glyycoprotein I, endothelium, inflammation, autoimmune disease, thrombosis, mouse models, lipopolysaccharide, endotoxin, mast cell, basophils and immunology.

 

Phone
9113 2976
Location
Level 3 Research and Education Building 4-10 South Street Kogarah NSW 2217
  • Book Chapters | 2019
    Qi M; Weaver JC; Krilis SA; Giannakopoulos B, 2019, 'Quantitation of total and free Thiol β2-Glycoprotein I levels for diagnostic and prognostic purposes in the antiphospholipid syndrome', in Functional Disulphide Bonds : Methods and Protocols, pp. 275 - 283, http://dx.doi.org/10.1007/978-1-4939-9187-7_17
    Book Chapters | 2019
    Qi M; Weaver JC; Rahgozar S; Giannakopoulos B; Krilis SA, 2019, 'Quantitation of total and free thiol angiotensinogen as a prognostic marker for preeclampsia', in Functional Disulphide Bonds : Methods and Protocols, pp. 285 - 293, http://dx.doi.org/10.1007/978-1-4939-9187-7_18
  • Journal articles | 2018
    Krilis M; Qi M; Qi J; Wong JWH; Guymer R; Liew G; Hunyor AP; Madigan M; McCluskey P; Weaver J; Krilis SA; Giannakopoulos B, 2018, 'Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration', Free Radical Biology and Medicine, 129, pp. 237 - 246, http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.034
    Journal articles | 2017
    Dong S; Qi M; Wang Y; Chen L; Weaver JC; Krilis SA; Giannakopoulos B, 2017, 'β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis', Oncotarget, 8, pp. 92652 - 92666, http://dx.doi.org/10.18632/oncotarget.21536
    Journal articles | 2017
    El-Assaad F; Qi M; Gordon AK; Qi J; Dong S; Passam F; Weaver JC; Giannakopoulos B; Krilis SA, 2017, 'Βeta 2-glycoprotein i protects mice against gram-negative septicaemia in a sexually dimorphic manner', Scientific Reports, 7, pp. 8201, http://dx.doi.org/10.1038/s41598-017-07945-8
    Journal articles | 2017
    Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940
    Journal articles | 2016
    Qi M; Abdelatti M; Krilis M; Madigan MC; Weaver J; Guymer RH; McCluskey P; Wang Y; Zhou S; Krilis SA; Giannakopoulos B, 2016, 'Do Beta 2-Glycoprotein i Disulfide Bonds Protect the Human Retina in the Setting of Age-Related Macular Degeneration?', Antioxidants and Redox Signaling, 24, pp. 32 - 38, http://dx.doi.org/10.1089/ars.2014.6052
    Journal articles | 2016
    Zhang P; Weaver JC; Chen G; Beretov J; Atsumi T; Qi M; Bhindi R; Qi JC; Madigan MC; Giannakopoulos B; Krilis SA, 2016, 'The fifth domain of beta 2 glycoprotein I protects from natural IgM mediated cardiac ischaemia reperfusion injury', PLoS ONE, 11, pp. e0152681, http://dx.doi.org/10.1371/journal.pone.0152681
    Journal articles | 2016
    Zhou S; Chen G; Qi M; El-Assaad F; Wang Y; Dong S; Chen L; Yu D; Weaver JC; Beretov J; Krilis SA; Giannakopoulos B, 2016, 'Gram negative bacterial inflammation ameliorated by the plasma protein beta 2-Glycoprotein I', Scientific Reports, 6, pp. 33656, http://dx.doi.org/10.1038/srep33656
    Journal articles | 2016
    Zhou S; Tanaka K; O'Keeffe M; Qi M; El-Assaad F; Weaver JC; Chen G; Weatherall C; Wang Y; Giannakopoulos B; Chen L; Yu DM; Hamilton MJ; Wensing LA; Stevens RL; Krilis SA, 2016, 'CD117+ dendritic and mast cells are dependent on RasGRP4 to function as accessory cells for optimal natural killer cell-mediated responses to lipopolysaccharide', PLoS ONE, 11, pp. e0151638, http://dx.doi.org/10.1371/journal.pone.0151638
    Journal articles | 2015
    Rahgozar S; Amirian T; Qi M; Shahshahan Z; Entezar-E-Ghaem M; Tehrani HG; Miroliaei M; Krilis SA; Giannakopoulos B, 2015, 'Improved assay for quantifying a redox form of angiotensinogen as a biomarker for pre-eclampsia: A case-control study', PLoS ONE, 10, pp. e0135905, http://dx.doi.org/10.1371/journal.pone.0135905
    Journal articles | 2014
    Giannakopoulos B; Mirarabshahi P; Qi M; Weatherall C; Qi JC; Tanaka K; Millar E; Vonthethoff L; Gatto D; Spielman D; Krilis SA, 2014, 'Deletion of the antiphospholipid syndrome autoantigen β2- glycoprotein i potentiates the lupus autoimmune phenotype in a toll-like receptor 7-mediated murine model', Arthritis and Rheumatology, 66, pp. 2270 - 2280, http://dx.doi.org/10.1002/art.38646
    Journal articles | 2013
    Krilis M; Mao Q; Madigan M; Wong J; Abulatti M; Guymer R; McCluskey P; Zhang P; Qi J; Krilis S; Giannakopoulos B, 2013, 'POST TRANSLATIONALLY MODIFIED COMPLEMENT FACTOR H IN AGE RELATED MACULAR DEGENERATION', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 41, pp. 17 - 17, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329507100022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Yong A; Pennings G; Wong C; Javadzadegan A; Brieger D; Lowe H; Qi M; Behnia M; Krilis S; Kritharides L, 2013, 'Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease', International Journal of Cardiology, 166, pp. 716 - 721, http://dx.doi.org/10.1016/j.ijcard.2011.11.093
    Journal articles | 2012
    Giannakopoulos B; Gao L; Qi M; Wong JW; Yu D; Vlachoyiannopoulos P; Moutsopoulos HM; Atsumi T; Koike T; Hogg PJ; Qi JC; Krilis S, 2012, 'Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis.', Journal of Autoimmunity, 39, pp. 121 - 129, http://dx.doi.org/10.1016/j.jaut.2012.05.005
    Journal articles | 2011
    Ioannou Y; Zhang JY; Qi M; Gao L; Qi JC; Yu D; Lau H; Sturgess AD; Vlachoyiannopoulos P; Moutsopoulos HM; Rahman A; Pericleousn C; Atsumi T; Koike T; Heritier S; Giannakopoulos B; Krilis S, 2011, 'Novel Assays of Thrombogenic Pathogenicity in the Antiphospholipid Syndrome Based on the Detection of Molecular Oxidative Modification of the Major Autoantigen beta(2)-Glycoprotein I', Arthritis Care & Research, 63, pp. 2774 - 2782, http://dx.doi.org/10.1002/art.30383
    Journal articles | 2011
    Passam F; Rahgozar S; Qi M; Raftery MJ; Wong JWH; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC; Giannakopoulos B; Hughes WE; Hogg PJ; Krilis S; Qi J, 2011, 'Redox control of â2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.', Journal of Thrombosis and Haemostasis, 8, pp. 1754 - 1762, http://dx.doi.org/10.1111/j.1538-7836.2010.03944.x
    Journal articles | 2011
    Yong A; Pennings GJ; Chang M; Hamzah A; Chung T; Qi M; Brieger D; Behnia M; Krilis S; Ng MK; Lowe HC; Kritharides L, 2011, 'Intracoronary shear-related up-regulation of platelet P-selectin and platelet monocyte aggregation despite the use of aspirin and clopidogral', Blood, 117, pp. 11 - 20, http://dx.doi.org/10.1182/blood-2010-04-278812
    Journal articles | 2010
    Ioannou Y; Zhang JY; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu DM; Hogg PJ; Krilis SA, 2010, 'Naturally occurring free thiols within β2-glycoprotein I in vivo: Nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury', Blood, 116, pp. 1961 - 1970, http://dx.doi.org/10.1182/blood-2009-04-215335
    Journal articles | 2010
    Passam F; Qi JC; Tanaka K; Matthaei K; Krilis S, 2010, 'In vivo modulation of angiogenesis by beta 2 glycoprotein I.', Journal of Autoimmunity, 35, pp. 232 - 240
    Journal articles | 2010
    Passam F; Rahgozar S; Qi M; Raftery MJ; Wong J; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC; Giannakopoulos B; Hughes WE; Hogg PJ; Krilis S, 2010, 'Beta 2 glycoprotein I is a substrate of thiol oxidoreductases', Blood, 116, pp. 1995 - 1997, http://bloodjournal.hematologylibrary.org/cgi/content/citation/116/11/1995
    Journal articles | 2008
    Katsoulotos GP; Qi M; Qi JC; Tanaka K; Hughes WE; Molloy T; Adachi R; Stevens RL; Krilis S, 2008, 'The Diacylglcerol-dependent translocation of ras guanine nucleotide -releasing protein 4 inside a human mast cell line results in substantional phenotypic changes ,including expressions of interluken 13 recepter a2', The Journal of Biological Chemistry, 283, pp. 1610 - 1621
    Journal articles | 2008
    Rahgozar S; Giannakopoulos B; Yan X; Wei J; Jian CQ; Gemmell R; Krilis SA, 2008, 'Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: Potentiation of this effect in the presence of anti-β2-glycoprotein I autoantibodies', Arthritis and Rheumatism, 58, pp. 1146 - 1155, http://dx.doi.org/10.1002/art.23387
    Journal articles | 2006
    Qi J; Wang JQ; Mandadi S; Tanaka K; Roufogalis BD; Madigan MC; Lai K; Yan F; Chong BH; Stevens RL; Krilis S, 2006, 'Human and mouse mast cells use the Tetraspanin CD9 as an alternate Interleukin 16 receptor', Blood, 107, pp. 135 - 142
    Journal articles | 2006
    Yu P; Yu DM; Qi JC; Wang J; Zhang QM; Zhang JY; Tang YZ; Xing QL; Li MZ, 2006, 'High D-glucose alters PI3K and Akt signaling and leads to endothelial cell migration, proliferation and angiogenesis dysfunction', National Medical Journal of China, 86, pp. 3425 - 3430, https://www.ncbi.nlm.nih.gov/pubmed/17313857
    Journal articles | 2004
    Shi T; Iverson GM; Qi JC; Cockerill KA; Linnik MD; Konecny P; Krilis SA, 2004, 'β2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: Loss of inhibition by clipped β2-glycoprotein I', Proceedings of the National Academy of Sciences of the United States of America, 101, pp. 3939 - 3944, http://dx.doi.org/10.1073/pnas.0400281101
    Journal articles | 2003
    Krilis S; Qi JC; Konecny P; Wang J, 2003, 'Hemopoietic Cells with Features of the Mast Cell and Basophil Lineages and their Potential Role in Allergy', Current Drug Targets, 2, pp. 293 - 302
    Journal articles | 2003
    Krilis S; Qi JC, 2003, 'MCs/Basophils in human Blood - What are they and how did they get there?', Allergy and Clinical Immunology International, 15, pp. 11 - 17
    Journal articles | 2003
    Li L; Li Y; Krilis S; Qi JC; Moore CH; Madigan MC; Katsoulotos GP, 2003, 'An antibody raised against in-vitro-derived human mast cells identifies mature mast cells and a population of cells that are Fc...., Tryptase, and chymase in a variety of human tissues', Journal of Histochemistry and Cytochemistry, 51, pp. 643 - 653
    Journal articles | 2002
    Qi JC; Stevens RL; Wadley RB; Collins AM; Cooley MA; Naif H; Nasr N; Cunningham AL; Katsoulotos GP; Wanigasek Y; Roufogalis B; Krilis S, 2002, 'IL-16 Regulation of Human Mast Cells/Basophils and Their Susceptibility to HIV-1', Journal of Immunology, 168, pp. 4127 - 4134, http://dx.doi.org/10.4049/jimmunol.168.8.4127
    Journal articles | 2002
    Wong GW; Foster PS; Yasuda S; Qi JC; Mahalingam S; Mellor EA; Katsoulotos G; Li X; Boyce JA; Krilis SA; Stevens RL, 2002, 'Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase γ: TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor α/signal transducer and activator of transcription (STAT) 6-dependent pathway', Journal of Biological Chemistry, 277, pp. 41906 - 41915, http://dx.doi.org/10.1074/jbc.M205868200
    Journal articles | 2002
    Wong GW; Foster PS; Yasuda S; Qi JC; Mahalingam S; Mellor EA; Li L; Katsoulotos GP; Boyce JA; Krilis S; Stevens RL, 2002, 'Biochemical and Functional Characterisation of Human Transmembrane Tryptase (TMT)/Tryptase y', The Journal of Biological Chemistry, 277, pp. 41906 - 41915
    Journal articles | 2001
    Li Y; Li L; Wadley RB; Reddel SW; Qi JC; Archis CA; Collins AM; Clarke E; Cooley MA; Kouts S; Naif H; Alali M; Cunningham AL; Wong GW; Stevens RL; Krilis S, 2001, 'Mast cell/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5 and CXCR4', Blood, pp. 3484 - 3490
    Journal articles | 1997
    Morrison NA; Qi JC; Tokita A; Kelly PJ; Crofts L; Nguyen TV; Sambrook PN; Elsman JA, 1997, 'Erratum: Prediction of bone density from vitamin D receptor alleles (Nature (1994) 367 (284-287))', Nature, 387, pp. 106, http://dx.doi.org/10.1038/387106a0
    Journal articles | 1996
    Hayes JG; Nguyen TV; Kelly PJ; Qi JC; Morrison NA; Pocock NA; Sambrook PN; Eisman JA, 1996, 'Heritability of hip geometry and association with the vitamin D receptor (VDR) gene alleles.', JOURNAL OF BONE AND MINERAL RESEARCH, 11, pp. S488 - S488, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996VA49500468&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1994
    Morrison NA; Qi JC; Tokita A; Kelly PJ; Crofts L; Nguyen TV; Sambrook PN; Eisman JA, 1994, 'Prediction of bone density from vitamin D receptor alleles', Nature, 367, pp. 284 - 287, http://dx.doi.org/10.1038/367284a0
  • Conference Papers | 2016
    Chen G; Weaver JC; Zhang P; Beretov J; Tatsuya A; Qi M; Bhindi R; Qi JC; Madigan MC; Giannakopoulos B; Krilis SA, 2016, 'BETA 2 GLYCOPROTEIN I PEPTIDE PROTECTS FROM CARDIAC ISCHEMIA REPERFUSION INJURY IN MICE', in CARDIOLOGY, KARGER, pp. 112 - 112, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383053200100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Rahgozar S; Passam F; Giannakopoulos B; Qi M; Chen QJ; Krilis S, 2011, 'The interaction of Beta 2 Glycoprotein I with vWF is thiol dependent and promotes the binding of GPIb alpha to vWF: Implications to the redox regulation of platelet adhesion', in Clinical Biochemistry, Pergamon-Elsevier Science Ltd, Kidlington, Oxford, England, pp. S255 - S255, presented at 12th Iranian Congress of Biochemistry & 4th International Congress of Biochemistry and Molecular Biology, Mashhad, Iran, 06 September 2011 - 09 September 2011, http://dx.doi.org/10.1016/j.clinbiochem.2011.08.636
    Conference Papers | 2010
    Ioannou Y; Zhang J-Y; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu D; Hogg PJ; Krilis S, 2010, 'HUMAN ENDOTHELIAL CELLS SECRETE OXIDOREDUCTASES ON THE CELL SURFACE AND CAN BOTH NITROSYLATE AND MODULATE THE REDOX STATE OF beta 2-GLYCOPROTEIN I', in RHEUMATOLOGY, OXFORD UNIV PRESS, ENGLAND, Birmingham, pp. I120 - I120, presented at Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British-Health-Professional-in-Rheumatology, ENGLAND, Birmingham, 21 April 2010 - 23 April 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276047500304&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Ioannou Y; Zhang J-Y; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu DM; Hogg PJ; Krilis SA, 2010, 'NATURALLY OCCURRING FREE THIOLS WITHIN beta 2-GLYCOPROEIN I IN VIVO: FUNCTIONAL IMPLICATIONS IN THE REGULATION OF OXIDATIVE STRESS INDUCED ENDOTHELIAL CELL INJURY', in RHEUMATOLOGY, OXFORD UNIV PRESS, ENGLAND, Birmingham, pp. I30 - I30, presented at Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British-Health-Professional-in-Rheumatology, ENGLAND, Birmingham, 21 April 2010 - 23 April 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276047500072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2009
    Yu P; Yu D; Krilis S; Qi J, 2009, 'Beta2-glycoprotein I inhibits insulin and insulin-like growth factor induced angiogenesis through its amino terminal domain', in DIABETOLOGIA, SPRINGER, AUSTRIA, Vienna, pp. S435 - S435, presented at 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, AUSTRIA, Vienna, 30 September 2009 - 02 October 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000269262401114&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2004
    Bester C; Shi T; Yang Q; Giannakopoulos B; Iverson GM; Qi JC; Cokerill KA; Linnik MD; Konecny P; Krilis SA, 2004, 'B-2-glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIA: Loss of inhibition by clipped B-2-glycoprotein I', in THROMBOSIS RESEARCH, PERGAMON-ELSEVIER SCIENCE LTD, AUSTRALIA, Sydney, pp. 609 - 609, presented at 11th International Congress on Antiphospholipid Antibodies, AUSTRALIA, Sydney, 14 November 2004 - 18 November 2004, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000228015200057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1