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Dr Joanna Achinger-Kawecka

Dr Joanna Achinger-Kawecka

Conjoint Senior Lecturer

PhD in Pharmacogenomics 2014 (University of Tuebingen, Germany)

 

Medicine & Health
School of Clinical Medicine

Dr Joanna Achinger-Kawecka is a Visiting Scientist at the Garvan Institute of Medical Research and Conjoint Senior Lecturer at St Vincent's Clinical School, UNSW Sydney.
E-mail
j.achinger-kawecka@unsw.edu.au
Location
Garvan Institute of Medical Research
  • Journal articles | 2026
    Campbell EM; Challis D; Clark SJ; Achinger-Kawecka J, 2026, 'Interplay of the 3D genome and epigenome in androgen-driven prostate cancer', Epigenomics, 18, pp. 739 - 751, http://dx.doi.org/10.1080/17501911.2026.2676129
    Journal articles | 2025
    Tian L; Jiao X; Wang C; Li D; Ertel A; Achinger-Kawecka J; Addya S; Soccio RE; Chen ER; Győrffy B; Di Sante G; Zhong Z; Alkhafaji H; Entcheva N; Campbell EM; McCue PA; Kossenkov AV; Pancsa R; Tompa P; Clark SJ; Pestell RG, 2025, 'PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding', Oncogene, 44, pp. 3476 - 3492, http://dx.doi.org/10.1038/s41388-025-03492-z
    Journal articles | 2024
    Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia KM; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Chen W; Pidsley R; Qu W; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, 2024, 'The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer', Nature Structural and Molecular Biology, 31, pp. 498 - 512, http://dx.doi.org/10.1038/s41594-023-01181-7
    Journal articles | 2024
    Chen W; Zeng YC; Achinger-Kawecka J; Campbell E; Jones AK; Stewart AG; Khoury A; Clark SJ, 2024, 'Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites', Nucleic Acids Research, 52, pp. 8086 - 8099, http://dx.doi.org/10.1093/nar/gkae530
    Journal articles | 2024
    Peters TJ; Meyer B; Ryan L; Achinger-Kawecka J; Song J; Campbell EM; Qu W; Nair S; Loi-Luu P; Stricker P; Lim E; Stirzaker C; Clark SJ; Pidsley R, 2024, 'Characterisation and reproducibility of the HumanMethylationEPIC v2.0 BeadChip for DNA methylation profiling', BMC Genomics, 25, http://dx.doi.org/10.1186/s12864-024-10027-5
    Journal articles | 2024
    Tian L; Jiao X; Wang C; Ertel A; Soccio R; Chen ER; Gyorffy B; Di Sante G; Zhong Z; Addya S; Mccue PA; Kossenkov AV; Achinger-Kawecka J; Clark S; Pestell RG, 2024, 'PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding', CANCER RESEARCH, 84, http://dx.doi.org/10.1158/1538-7445.AM2024-3582
    Journal articles | 2023
    Achinger-Kawecka J; Correa S; Hu J; Li G; Lindeboom RGH; Misale S; Monkkonen T; Nirmal AJ; Prekovic S; Sinha S; Trigos AS; Watson CJ, 2023, 'The 2023 generation', Nature Cancer, 4, pp. 1630 - 1635, http://dx.doi.org/10.1038/s43018-023-00681-1
    Journal articles | 2023
    Hastings JF; Latham SL; Kamili A; Wheatley MS; Han JZR; Wong-Erasmus M; Phimmachanh M; Nobis M; Pantarelli C; Cadell AL; O’Donnell YEI; Leong KH; Lynn S; Geng FS; Cui L; Yan S; Achinger-Kawecka J; Stirzaker C; Norris MD; Haber M; Trahair TN; Speleman F; De Preter K; Cowley MJ; Bogdanovic O; Timpson P; Cox TR; Kolch W; Fletcher JI; Fey D; Croucher DR, 2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.abp8314
    Journal articles | 2022
    Brown LJ; Achinger-Kawecka J; Portman N; Clark S; Stirzaker C; Lim E, 2022, 'Epigenetic Therapies and Biomarkers in Breast Cancer', Cancers, 14, http://dx.doi.org/10.3390/cancers14030474
    Journal articles | 2021
    Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair S; Yong A; Wilkinson A; Clifton S; Milioli H; Alexandrou S; Caldon E; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong E; Hickey T; Lim E; Clark S, 2021, 'Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer', , http://dx.doi.org/10.1101/2021.06.21.449340
    Journal articles | 2021
    Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109722
    Journal articles | 2021
    Giles KA; Gould CM; Achinger-Kawecka J; Page SG; Kafer GR; Rogers S; Luu PL; Cesare AJ; Clark SJ; Taberlay PC, 2021, 'BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer', Clinical Epigenetics, 13, http://dx.doi.org/10.1186/s13148-021-01023-7
    Journal articles | 2020
    Achinger-Kawecka J; Valdes-Mora F; Luu PL; Giles KA; Caldon CE; Qu W; Nair S; Soto S; Locke WJ; Yeo-Teh NS; Gould CM; Du Q; Smith GC; Ramos IR; Fernandez KF; Hoon DS; Gee JMW; Stirzaker C; Clark SJ, 2020, 'Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer', Nature Communications, 11, pp. 320, http://dx.doi.org/10.1038/s41467-019-14098-x
    Journal articles | 2020
    Du Q; Smith G; Luu PL; Ferguson J; Armstrong N; Caldon E; Campbell E; Nair S; Zotenko E; Gould C; Buckley M; Kaczorowski D; Barton K; Deveson I; Smith M; Powell J; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark S, 2020, 'DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity', , http://dx.doi.org/10.1101/2020.10.15.338855
    Journal articles | 2020
    Giles KA; Gould CM; Achinger-Kawecka J; Page SG; Kafer G; Luu P-L; Cesare AJ; Clark SJ; Taberlay PC, 2020, 'BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells', , http://dx.doi.org/10.1101/2020.07.03.187385
    Journal articles | 2020
    Khoury A; Achinger-Kawecka J; Bert SA; Smith GC; French HJ; Luu PL; Peters TJ; Du Q; Parry AJ; Valdes-Mora F; Taberlay PC; Stirzaker C; Statham AL; Clark SJ, 2020, 'Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-019-13753-7
    Journal articles | 2019
    Giles KA; Gould CM; Du Q; Skvortsova K; Song JZ; Maddugoda MP; Achinger-Kawecka J; Stirzaker C; Clark SJ; Taberlay PC, 2019, 'Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups', Epigenetics and Chromatin, 12, http://dx.doi.org/10.1186/s13072-019-0258-9
    Journal articles | 2018
    Fuksiewicz M; Kotowicz B; Rutkowski A; Achinger-Kawecka J; Wagrodzki M; Kowalska MM, 2018, 'The assessment of clinical usage and prognostic value of YKL-40 serum levels in patients with rectal cancer without distant metastasis', Technology in Cancer Research and Treatment, 17, http://dx.doi.org/10.1177/1533033818765209
    Journal articles | 2017
    Achinger-Kawecka J; Clark SJ, 2017, 'Disruption of the 3D cancer genome blueprint', Epigenomics, 9, pp. 47 - 55, http://dx.doi.org/10.2217/epi-2016-0111
    Journal articles | 2016
    Achinger-Kawecka J; Taberlay PC; Clark SJ, 2016, 'Alterations in three-dimensional organization of the cancer genome and epigenome', Cold Spring Harbor Symposia on Quantitative Biology, 81, pp. 41 - 51, http://dx.doi.org/10.1101/sqb.2016.81.031013
    Journal articles | 2016
    Taberlay PC; Achinger-Kawecka J; Lun ATL; Buske FA; Sabir K; Gould CM; Zotenko E; Bert SA; Giles KA; Bauer DC; Smyth GK; Stirzaker C; O'Donoghue SI; Clark SJ, 2016, 'Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations.', Genome Res, 26, pp. 719 - 731, http://dx.doi.org/10.1101/gr.201517.115
    Journal articles | 2013
    Hoppe R; Achinger-Kawecka J; Winter S; Fritz P; Lo WY; Schroth W; Brauch H, 2013, 'Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment', European Journal of Cancer, 49, pp. 3598 - 3608, http://dx.doi.org/10.1016/j.ejca.2013.07.145
  • Working Papers |
    Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell E; Nair SS; Zotenko E; Gould CM; Buckley M; Kaczorowski D; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/2020.10.15.338855
  • Conference Abstracts | 2024
    Tian L; Jiao X; Wang C; Ertel A; Soccio R; Chen ER; Győrffy B; Sante GD; Zhong Z; Addya S; McCue PA; Kossenkov AV; Achinger-Kawecka J; Clark S; Pestell RG, 2024, 'Abstract 3582: PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. 3582 - 3582, http://dx.doi.org/10.1158/1538-7445.am2024-3582
    Conference Abstracts | 2019
    Stirzaker C; Chia KM; Portman N; Milioli HH; Clifton S; Achinger-Kawecka J; Nair S; Lim E; Clark S, 2019, 'DNA demethylation agents as a therapeutic approach in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P049
    Conference Papers | 2013
    Hoppe R; Achinger-Kawecka J; Winter S; Fritz P; Lo W-Y; Schroth W; Brauch H, 2013, 'Abstract 1938: Increased miR-126 and miR-375 expression in primary ER-positive breast cancer predict longer relapse-free time following treatment with tamoxifen.', in Cancer Research, American Association for Cancer Research (AACR), pp. 1938 - 1938, http://dx.doi.org/10.1158/1538-7445.am2013-1938
    Preprints |
    Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer, http://dx.doi.org/10.1101/2021.06.21.449340
    Preprints |
    Campbell EM; Laven-Law G; Jones A; Challis D; Peters TJ; Smith G; Colino-Sanguino Y; Moulder D; Du Q; Giles KA; Thomson DW; Stirzaker C; Hickey TA; Mora FV; Khoury A; Clark SJ; Achinger-Kawecka J, Androgen stimulation rapidly reorganizes temporal 3D genome and epigenome states to trigger AR-mediated transcription in prostate cancer, http://dx.doi.org/10.1101/2024.12.17.628805
    Preprints |
    Giles KA; Gould CM; Achinger-Kawecka J; Page SG; Kafer G; Luu P-L; Cesare AJ; Clark SJ; Taberlay PC, BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells, http://dx.doi.org/10.1101/2020.07.03.187385
    Preprints |
    King C; Iqbal M; Shokati E; Li CMY; Li R; Tomita Y; Smith E; Achinger-Kawecka J; Wang S; Fenix K, Comparative benchmarking of single-cell transcriptomes and immune repertoires across technologies, http://dx.doi.org/10.64898/2026.04.20.719117

2022 - St Vincent’s Campus Rising Star Award

2022 - Franklin Women 2022 Teresa Anderson Award

2019 - Best Selected Speaker Prize, 2019 Post-Doc Symposium, Garvan Institute


2018 - CASS Foundation Travel Grant


2017 - The Ian Potter Foundation Travel Grant


2016 - Best Postdoc Prize, 24th St Vincent’s Campus Research Symposium


2016 - Heliflite Young Explorer Award


2015 - Best Oral Presentation Prize, 23rd St Vincent’s Campus Research Symposium


2011 – EU FP7 Marie Curie Initial Training Network “Fighting Drug Failure” Fellowship