Mr John Grady

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Book Chapters | 2025

Lin FP; Tran M; Thavaneswaran S; Grady JP; Kansara M; Chan J; Ballinger ML; Simes J; Thomas DM, 2025, 'Automating Precision Oncology Literature Curation: A Decision Tree Approach Using Large Language Models', in , pp. 248 - 252, http://dx.doi.org/10.3233/SHTI250839
Journal articles | 2026

Carlino MS; Gao B; Michael M; Marshall H; Gunjur A; Chan H; Zielinski R; So J; Harris SJ; Kee D; Collins IM; Lam WS; Lyle M; Underhill C; Brown MP; Harrup R; Wong SF; Grady J; Ballinger M; Tavancheh E; Thomas DM; Palmer J; Wilkie K; Cebon J; Klein O, 2026, 'Nivolumab and Ipilimumab in Advanced Mismatch Repair–Deficient/Microsatellite Instability–High Noncolorectal Cancers: A Nonrandomized Clinical Trial', JAMA Oncology, 12, pp. 39 - 47, http://dx.doi.org/10.1001/jamaoncol.2025.4721

Journal articles | 2026

Cote GM; Aberoumand M; Choy E; Sebastian L; Mazzola E; Grimison P; Merriam P; Ballinger M; Thavaneswaran S; Lin F; Grady JP; Millward M; Brown MP; Harrup R; Espinoza D; Demetri G; Littlefield BA; Simes RJ; George S; Thomas D, 2026, 'A Phase 2 Study of the Eribulin in Patients with Metastatic Angiosarcoma and Epithelioid Hemangioendothelioma (EHE).', Clin Cancer Res, http://dx.doi.org/10.1158/1078-0432.CCR-25-3362

Journal articles | 2026

Koh B; Thavaneswaran S; Lin F; Grady J; Maddula M; Haghighi KS; Kansara M; Huang ML; Ballinger ML; Simes J; Thomas DM; Goldstein D, 2026, 'Exceptional Response to Durvalumab and Tremelimumab in Pancreatic Acinar Cell Carcinoma With Ultramutated Phenotype Associated With a DNA Polymerase-ε Mutation', JCO Precision Oncology, 10, http://dx.doi.org/10.1200/PO-25-01003

Journal articles | 2026

Lin FP; Thavaneswaran S; Grady JP; Napier CE; Kansara M; Sebastian L; Kee D; Desai J; Zaheed M; Chinchen S; Oakes SR; Blackburn J; Scott HS; Glover A; Fox SB; Goldstein D; Leo P; Amanuel B; Mersiades A; Millward M; Brown MP; Charakidis M; Pokorny AMJ; Craft P; Espinoza D; Grimison P; Harrup R; Joshua AM; O’Byrne K; Lee CK; Cowley MJ; Ballinger ML; Simes J; Thomas DM, 2026, 'Genomic Therapy Matching in Rare and Refractory Cancers', JAMA Oncology, http://dx.doi.org/10.1001/jamaoncol.2026.0127

Journal articles | 2026

Nagrial A; Carlino MS; Gunjur A; Brown MP; Harris S; Underhill C; Zielinski R; Kee D; Lam W-S; Chan H; Harrup R; So J; Collins IM; Michael M; Chionh F; Uy C; Mariadason J; Torres J; Ballinger ML; Grady JP; Tavancheh E; Palmer J; Thomas DM; Wilkie K; Cebon J; Klein O, 2026, 'Nivolumab and ipilimumab combination treatment in patients with advanced intrahepatic cholangiocarcinoma and gallbladder cancer: Results from the phase II MoST-CIRCUIT trial.', Clin Cancer Res, http://dx.doi.org/10.1158/1078-0432.CCR-25-4009

Journal articles | 2026

Southi N; Sim H-W; Grady J; Ballinger M; Thomas D; Thavaneswaran S, 2026, '145P Characterising homologous recombination deficiencies in gliomas', ESMO Open, 11, pp. 106288 - 106288, http://dx.doi.org/10.1016/j.esmoop.2026.106288

Journal articles | 2025

Gao B; Carlino MS; Michael M; Underhill C; Marshall H; Gunjur A; So J; Kee D; Antill Y; Lam WS; Chan H; Harrup R; Hamilton A; Grady J; Ballinger M; Tavancheh E; Yoon WH; Palmer J; Thomas D; Wilkie K; Cebon J; Klein O, 2025, 'Nivolumab and Ipilimumab Combination Treatment in Advanced Ovarian and Endometrial Clear Cell Cancers: A Nonrandomized Clinical Trial', JAMA Oncology, 11, pp. 982 - 989, http://dx.doi.org/10.1001/jamaoncol.2025.1916

Journal articles | 2025

Gaughran G; Mamrot J; Fitzgerald S; Kee D; Napier C; Harris SJ; Thavaneswaran S; Grady J; Davies A; Bellinger M; Thomas DM, 2025, '797P Real-world experience of liquid biopsy (LBx) vs tissue-based comprehensive genomic profiling (tCGP)', Annals of Oncology, 36, pp. S1995 - S1996, http://dx.doi.org/10.1016/j.annonc.2025.10.1211

Journal articles | 2025

Gaughran G; Zaheed M; Harris SJ; Napier C; Yap M; Bellinger M; Grady J; Kee D; Caillet V; Davies A; Thavaneswaran S; Thomas DM, 2025, '777P HIF2α pathway aberrations across tumour types: A rare but actionable entity with high germline conversion', Annals of Oncology, 36, pp. S1990 - S1990, http://dx.doi.org/10.1016/j.annonc.2025.10.1192

Journal articles | 2025

Jung MS; Poltavets V; Skhinas JN; Tax G; Kamili A; Xie J; Ghamrawi S; Graber P; Mao J; Wong-Erasmus M; Cui L; Kimpton K; Venkat P; Mayoh C; Lin A; Fleuren EDG; Fordham AM; Barger Z; Grady J; Thomas DM; Du EY; Graf NS; Cowley MJ; Gifford AJ; Fletcher JI; Lau LMS; Dolman MEM; Gooding JJ; Kavallaris M; Dolman E, 2025, 'High-throughput 3D engineered paediatric tumour models for precision medicine', Molecular Systems Biology, 21, pp. 1748 - 1777, http://dx.doi.org/10.1038/s44320-025-00152-y

Journal articles | 2025

Kansara M; Thavaneswaran S; Lin FP; Kok P-S; Grady J; Thomas H; Corpuz T; Mundra P; Lu J; Ballinger M; Desai J; Harrup RA; Craft P; Charakidis M; O'Byrne KJ; Selva-Nayagam S; Millwar M; Grimiso P; Simes J; Thomas D, 2025, 'A phase II trial of palbociclib and avelumab in advanced solid tumours with CDK4/6 pathway alterations', ANNALS OF ONCOLOGY, 36, http://dx.doi.org/10.1016/j.annonc.2025.08.2175

Journal articles | 2025

Lin FP-Y; Goldstein D; Grady JP; Napier C; Thavaneswaran S; Pitiyarachchi O; Kansara M; Chantrill LA; Sjoquist K; Thornton K; Raina A; Magenau A; Simes J; Ballinger ML; Sharbeen G; Timpson P; Pajic M; Phillips P; Thomas DM, 2025, 'Genomic and outcome analysis of recurrent versus de novo metastatic pancreatic ductal adenocarcinoma (PDAC) receiving systemic therapy: Results from the Australian MoST and CaSP screening programs.', JOURNAL OF CLINICAL ONCOLOGY, 43, pp. 4120 - 4120, http://dx.doi.org/10.1200/JCO.2025.43.16_suppl.4120

Journal articles | 2025

Lin FP-Y; Huang ML; Grady JP; Thavaneswaran S; Kansara M; Napier C; Ballinger ML; Simes J; Thomas DM, 2025, 'Machine learning-based classification of cancer types using genomic profiling data from the Australian Molecular Screening and Therapeutics (MoST) program.', JOURNAL OF CLINICAL ONCOLOGY, 43, pp. e13683 - e13683, http://dx.doi.org/10.1200/JCO.2025.43.16_suppl.e13683

Journal articles | 2025

Novis E; Glover A; Grady JP; Silvestri A; Thavaneswaran S; Lin F; Ballinger ML; Thomas DM, 2025, 'Oncogenic mutations in the TP53 and PI-3 kinase/AKT pathway are independent predictors of survival for advanced thyroid cancer: Analysis from the Molecular Screening and Therapeutics (MoST) program', Surgery United States, 177, http://dx.doi.org/10.1016/j.surg.2024.05.058

Journal articles | 2025

Pavlakis N; Lee CK; Ballinger ML; Brown CSB; Grady JP; Lin F; Thavaneswaran S; Mersiades AJ; Di-Xin Zhou D; Lee J; John T; Napier CE; Cummins MM; Collignon E; Sebastian L; Turnbull OMH; Simes J; Thomas DM; Solomon BJ, 2025, 'P2.06.61 ASPiRATION. Australian Nationwide Cohort Study to Assess Impact of Comprehensive Genomic Profiling in Metastatic Lung Cancer', Journal of Thoracic Oncology, 20, pp. S318 - S319, http://dx.doi.org/10.1016/j.jtho.2025.09.595

Journal articles | 2025

Thavaneswaran S; Lin F; Espinoza D; Grady J; Kok PS; Chinchen S; Pavlakis N; Andelkovic V; Charakidis M; Craft P; Brown M; Desai J; Lau P; Kansara M; Simes J; Thomas D, 2025, 'A signal-seeking phase 2 study of tremelimumab in advanced cancers with high tumour mutational burden', Npj Precision Oncology, 9, http://dx.doi.org/10.1038/s41698-025-01156-5

Journal articles | 2025

Thavaneswaran S; Sim HW; Grady J; Espinoza D; Huang ML; Lin F; McGrath M; Desai J; Charakidis M; Brown M; Kansara M; Simes J; Thomas D, 2025, 'A phase II trial of larotrectinib in tumors with NTRK fusions or extremes of NTRK mRNA overexpression identified by comprehensive genomic profiling', Oncologist, 30, http://dx.doi.org/10.1093/oncolo/oyae339

Journal articles | 2025

Zhu Y; Lin FP-Y; So JY; Oh EW; Philipsen S; Thomas DM; Grady JP; Lawrence BJ; Wilson MK, 2025, 'Actionability of genomic alterations in the Molecular Screening and Therapeutics (MoST) program in New Zealand (NZ) depending on residence in NZ or Australia.', JOURNAL OF CLINICAL ONCOLOGY, 43, pp. E13763 - E13763, http://dx.doi.org/10.1200/JCO.2025.43.16_suppl.e13763

Journal articles | 2024

Thavaneswaran S; Lin F; Grady JP; Espinoza D; Huang ML; Chinchen S; Sebastian L; Kansara M; Mersiades T; Lee CK; Desai J; Grimison P; Brown M; Millward M; Harrup R; O’Byrne K; Nagrial A; Craft P; Simes J; Joshua AM; Thomas DM, 2024, 'A signal-seeking phase 2 study of Trastuzumab emtansine in tumours harbouring HER2 amplification or mutation', Npj Precision Oncology, 8, http://dx.doi.org/10.1038/s41698-024-00698-4

Journal articles | 2023

Kansara M; Lin FP-Y; Thavaneswaran S; Napier CE; Grady JP; Ballinger ML; Simes J; Thomas DM, 2023, 'Genomic alterations associated with response to immune checkpoint inhibitors in rare cancers: A biomarker exploration study from the Australian Molecular Screening and Therapeutics (MoST) Program.', Journal of Clinical Oncology, 41, pp. 2594 - 2594, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2594

Journal articles | 2023

Lin FP-Y; Thavaneswaran S; Napier CE; Grady JP; Kansara M; Sebastian L; Kee D; Zaheed M; Millward M; Brown MP; Charakidis M; Craft PS; Grimison PS; Harrup RA; O'Byrne KJ; Desai J; Lee CK; Ballinger ML; Simes J; Thomas DM, 2023, 'Genomic therapy matching in rare and refractory cancers: Updated results from a retrospective cohort study in the Molecular Screening and Therapeutic (MoST) program', JOURNAL OF CLINICAL ONCOLOGY, 41, http://dx.doi.org/10.1200/JCO.2023.41.16_suppl.1540

Journal articles | 2023

Sharaf R; Jin DX; Grady J; Napier C; Ebot E; Frampton GM; Albacker LA; Thomas DM; Montesion M, 2023, 'A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content', Npj Genomic Medicine, 8, http://dx.doi.org/10.1038/s41525-023-00369-6

Journal articles | 2023

Thavaneswaran S; Kansara M; Lin F; Espinoza D; Grady JP; Lee CK; Ballinger ML; Sebastian L; Corpuz T; Qiu MR; Mundra P; Bailey CG; Schmitz U; Simes J; Joshua AM; Thomas DM, 2023, 'A signal-seeking Phase 2 study of olaparib and durvalumab in advanced solid cancers with homologous recombination repair gene alterations', British Journal of Cancer, 129, pp. 475 - 485, http://dx.doi.org/10.1038/s41416-023-02311-0

Journal articles | 2023

Thavaneswaran S; Lin FP-Y; Napier CE; Grady JP; Ballinger ML; Kansara M; Grimison PS; Pavlakis N; Wong MK; Sjoquist KM; Goldstein D; Chantrill LA; Simes J; Thomas DM, 2023, 'Genomic targetability and survival outcomes of biliary tract cancers (BTC): A retrospective cohort study of the Australian Molecular Screening and Therapeutics (MoST) program', JOURNAL OF CLINICAL ONCOLOGY, 41, http://dx.doi.org/10.1200/JCO.2023.41.16_suppl.4093

Journal articles | 2023

Thavaneswaran S; Mersiades A; Lin FP-Y; Espinoza D; Grady JP; Lee CK; Desai J; Brown MP; Grimison PS; O'Byrne KJ; Harrup RA; Nagrial A; Sebastian L; Chinchen S; Kansara M; Craft PS; Millward M; Simes J; Joshua AM; Thomas DM, 2023, 'Trastuzumab emtansine (T-DM1) in advanced cancers with HER2 mutations or amplification: Results from the Molecular Screening and Therapeutics (MoST) Program substudy', JOURNAL OF CLINICAL ONCOLOGY, 41, http://dx.doi.org/10.1200/JCO.2023.41.16_suppl.3127

Journal articles | 2022

Sharaf R; Jin DX; Grady J; Frampton GM; Albacker LA; Thomas D; Montesion M, 2022, '1487MO A pan-sarcoma investigation of genetic alterations associated with high telomeric content', Annals of Oncology, 33, pp. S1226 - S1227, http://dx.doi.org/10.1016/j.annonc.2022.07.1590

Journal articles | 2022

Thavaneswaran S; Chan WY; Asghari R; Grady JP; Deegan M; Jansen VM; Thomas DM, 2022, 'Clinical Response to Seribantumab, an Anti-Human Epidermal Growth Factor Receptor-3 Immunoglobulin 2 Monoclonal Antibody, in a Patient With Metastatic Pancreatic Ductal Adenocarcinoma Harboring an NRG1 Fusion', JCO PRECISION ONCOLOGY, 6, http://dx.doi.org/10.1200/PO.22.00263

Journal articles | 2021

Lin FP; Thavaneswaran S; Grady JP; Ballinger M; Kansara M; Oakes SR; Desai J; Lee CK; Simes J; Thomas DM, 2021, 'Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology', Npj Precision Oncology, 5, pp. 58, http://dx.doi.org/10.1038/s41698-021-00194-z

Journal articles | 2020

Joshua AM; Prawira A; Thavaneswaran S; Cosman R; Lee CK; Sjoquist KM; Simes J; Thomas DM; Espinoza D; Sebastian L; Ballinger ML; Hague W; Chinchen S; Collignon E; Kansara M; Palacios T; Grady J; Barker H; Thornton K, 2020, 'A signal-seeking trial of olaparib and durvalumab in homologous repair-deficient tumors: A sub-study of the cancer molecular screening and therapeutics (MoST) program.', Journal of Clinical Oncology, 38, pp. 3073 - 3073, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3073

Journal articles | 2020

Mueller SA; Gauthier MEA; Blackburn J; Grady JP; Kraitsek S; Hajdu E; Dettmer MS; Dahlstrom JE; Lee CS; Luk PP; Yu B; Giger R; Kummerfeld S; Clark JR; Gupta R; Cowley MJ, 2020, 'Molecular patterns in salivary duct carcinoma identify prognostic subgroups', Modern Pathology, 33, pp. 1896 - 1909, http://dx.doi.org/10.1038/s41379-020-0576-2

Journal articles | 2020

Shukla A; Nguyen THM; Moka SB; Ellis JJ; Grady JP; Oey H; Cristino AS; Khanna KK; Kroese DP; Krause L; Dray E; Fink JL; Duijf PHG, 2020, 'Chromosome arm aneuploidies shape tumour evolution and drug response', Nature Communications, 11, pp. 449 - 449, http://dx.doi.org/10.1038/s41467-020-14286-0

Journal articles | 2020

Smith AM; Zhang CRC; Cristino AS; Grady JP; Fink JL; Moore AS, 2020, 'Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors.', Oncotarget, 11, pp. 305, http://dx.doi.org/10.18632/oncotarget.27402

Journal articles | 2019

Dutta AK; Fink JL; Grady JP; Morgan GJ; Mullighan CG; To LB; Hewett DR; Zannettino ACW, 2019, 'Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability.', Leukemia, 33, pp. 457 - 468, http://dx.doi.org/10.1038/s41375-018-0206-x

Journal articles | 2019

Hayhurst H; Anagnostou M-E; Bogle HJ; Grady JP; Taylor RW; Bindoff LA; McFarland R; Turnbull DM; Lax NZ, 2019, 'Dissecting the neuronal vulnerability underpinning Alpers' syndrome: a clinical and neuropathological study.', Brain Pathol, 29, pp. 97 - 113, http://dx.doi.org/10.1111/bpa.12640

Journal articles | 2019

McCabe M; Gauthier M-E; Chan C-L; Thompson T; De Sousa S; Puttick C; Grady J; Gayevskiy V; Tao J; Ying K; Cipponi A; Deng N; Swarbrick A; Thomas M; kConFab ; Lord R; Johns A; Kohonen-Corish M; O'Toole S; Clark J; Mueller S; Gupta R; McCormack A; Dinger M; Cowley M; Bastick P; Friedlander M; Colley A; Andrews L; Young M-A; Tucker K; Williams R; Aghmesheh M, 2019, 'Development and validation of a targeted gene sequencing panel for application to disparate cancers', Scientific Reports, 9, pp. 17052, http://dx.doi.org/10.1038/s41598-019-52000-3

Journal articles | 2019

McCabe MJ; Pinese M; Chan CL; Sheriff N; Thompson TJ; Grady J; Wong M; Gauthier MEA; Puttick C; Gayevskiy V; Hajdu E; Wong SQ; Barrett W; Earls P; Lukeis R; Cheng YY; Lin RCY; Thomas DM; Watkins DN; Dinger ME; McCormack AI; Cowley MJ; Wong-Erasmus M, 2019, 'Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases', Cold Spring Harbor Molecular Case Studies, 5, pp. a003764, http://dx.doi.org/10.1101/mcs.a003764

Journal articles | 2019

Mueller SA; Grady J; Dettmer M; Gauthier M-EA; Hajdu E; Blackburn J; Giger R; Dahlstrom JE; Luk P; Lee S; Kratisek S; Yu B; Clark JR; Cowley MJ; Gupta R, 2019, 'The targetable genomic landscape of salivary duct carcinoma', Pathology, 51, pp. S83 - S83, http://dx.doi.org/10.1016/j.pathol.2018.12.210

Journal articles | 2019

Smith AM; Zhang CRC; Cristino AS; Grady JP; Fink JL; Moore AS, 2019, 'PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors.', Oncotarget, 10, pp. 5755 - 5767, http://dx.doi.org/10.18632/oncotarget.27206

Journal articles | 2018

Grady JP; Pickett SJ; Ng YS; Alston CL; Blakely EL; Hardy SA; Feeney CL; Bright AA; Schaefer AM; Gorman GS; McNally RJ; Taylor RW; Turnbull DM; McFarland R, 2018, 'mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease.', EMBO Mol Med, 10, http://dx.doi.org/10.15252/emmm.201708262

Journal articles | 2018

Lin C-Y; Shukla A; Grady JP; Fink JL; Dray E; Duijf PHG, 2018, 'Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes.', Cancers (Basel), 10, http://dx.doi.org/10.3390/cancers10010013

Journal articles | 2018

Parrish RR; Grady J; Codadu NK; Racca C; Trevelyan AJ, 2018, 'Graphical user interface for simultaneous profiling of activity patterns in multiple neuronal subclasses.', Data Brief, 20, pp. 226 - 233, http://dx.doi.org/10.1016/j.dib.2018.07.069

Journal articles | 2018

Parrish RR; Grady J; Codadu NK; Trevelyan AJ; Racca C, 2018, 'Simultaneous profiling of activity patterns in multiple neuronal subclasses.', J Neurosci Methods, 303, pp. 16 - 29, http://dx.doi.org/10.1016/j.jneumeth.2018.03.012

Journal articles | 2018

Pickett SJ; Grady JP; Ng YS; Gorman GS; Schaefer AM; Wilson IJ; Cordell HJ; Turnbull DM; Taylor RW; McFarland R, 2018, 'Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors.', Ann Clin Transl Neurol, 5, pp. 333 - 345, http://dx.doi.org/10.1002/acn3.532

Journal articles | 2018

Reeve AK; Grady JP; Cosgrave EM; Bennison E; Chen C; Hepplewhite PD; Morris CM, 2018, 'Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson's disease', NPJ PARKINSONS DISEASE, 4, http://dx.doi.org/10.1038/s41531-018-0044-6

Journal articles | 2018

Rocha MC; Rosa HS; Grady JP; Blakely EL; He L; Romain N; Haller RG; Newman J; McFarland R; Ng YS; Gorman GS; Schaefer AM; Tuppen HA; Taylor RW; Turnbull DM, 2018, 'Pathological mechanisms underlying single large-scale mitochondrial DNA deletions.', Ann Neurol, 83, pp. 115 - 130, http://dx.doi.org/10.1002/ana.25127

Journal articles | 2018

Sithamparanathan S; Rocha MC; Parikh JD; Rygiel KA; Falkous G; Grady J; Hollingsworth KG; Trenell MI; Taylor RW; Turnbull DM; Gorman GS; Corris P, 2018, 'Skeletal Muscle Mitochondrial Oxidative Phosphorylation Function in Idiopathic Pulmonary Arterial Hypertension – in Vivo and in Vitro Study', American Journal of Respiratory and Critical Care Medicine, 197, pp. a2443 - a2443, http://dx.doi.org/10.1164/ajrccm-conference.2018.197.1_meetingabstracts.a2443

Journal articles | 2018

Sithamparanathan S; Rocha MC; Parikh JD; Rygiel KA; Falkous G; Grady JP; Hollingsworth KG; Trenell MI; Taylor RW; Turnbull DM; Gorman GS; Corris PA, 2018, 'Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study.', Pulm Circ, 8, pp. 2045894018768290, http://dx.doi.org/10.1177/2045894018768290

Journal articles | 2018

Su T; Grady JP; Afshar S; McDonald SA; Taylor RW; Turnbull DM; Greaves LC, 2018, 'Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.', J Pathol, 246, pp. 427 - 432, http://dx.doi.org/10.1002/path.5156

Journal articles | 2017

Dutta AK; Hewett DR; Fink JL; Grady JP; Zannettino ACW, 2017, 'Cutting edge genomics reveal new insights into tumour development, disease progression and therapeutic impacts in multiple myeloma.', Br J Haematol, 178, pp. 196 - 208, http://dx.doi.org/10.1111/bjh.14649

Journal articles | 2017

Martikainen MH; Grady JP; Ng YS; Alston CL; Gorman GS; Taylor RW; McFarland R; Turnbull DM, 2017, 'Decreased male reproductive success in association with mitochondrial dysfunction.', Eur J Hum Genet, 25, pp. 1162 - 1164, http://dx.doi.org/10.1038/ejhg.2017.114

Journal articles | 2016

Chrysostomou A; Grady JP; Laude A; Taylor RW; Turnbull DM; Lax NZ, 2016, 'Investigating complex I deficiency in Purkinje cells and synapses in patients with mitochondrial disease.', Neuropathol Appl Neurobiol, 42, pp. 477 - 492, http://dx.doi.org/10.1111/nan.12282

Journal articles | 2016

Dobson PF; Rocha MC; Grady JP; Chrysostomou A; Hipps D; Watson S; Greaves LC; Deehan DJ; Turnbull DM, 2016, 'Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(-/-) mice.', Sci Rep, 6, pp. 31907, http://dx.doi.org/10.1038/srep31907

Journal articles | 2016

Lax NZ; Grady J; Laude A; Chan F; Hepplewhite PD; Gorman G; Whittaker RG; Ng Y; Cunningham MO; Turnbull DM, 2016, 'Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease.', Neuropathol Appl Neurobiol, 42, pp. 180 - 193, http://dx.doi.org/10.1111/nan.12238

Journal articles | 2016

Ng YS; Feeney C; Schaefer AM; Holmes CE; Hynd P; Alston CL; Grady JP; Roberts M; Maguire M; Bright A; Taylor RW; Yiannakou Y; McFarland R; Turnbull DM; Gorman GS, 2016, 'Pseudo-obstruction, stroke, and mitochondrial dysfunction: A lethal combination.', Ann Neurol, 80, pp. 686 - 692, http://dx.doi.org/10.1002/ana.24736

Journal articles | 2016

Ng YS; Grady JP; Lax NZ; Bourke JP; Alston CL; Hardy SA; Falkous G; Schaefer AG; Radunovic A; Mohiddin SA; Ralph M; Alhakim A; Taylor RW; McFarland R; Turnbull DM; Gorman GS, 2016, 'Sudden adult death syndrome in m.3243A>G-related mitochondrial disease: an unrecognized clinical entity in young, asymptomatic adults.', Eur Heart J, 37, pp. 2552 - 2559, http://dx.doi.org/10.1093/eurheartj/ehv306

Journal articles | 2016

Ng YS; Hynd P; Feeney C; Schaefer A; Holmes C; Alston C; Grady J; Roberts M; Taylor R; Yiannakou Y; McFarland R; Turnbull D, 2016, 'Chronic Gastrointestinal Dysmotility in Adult m.3243A>G-Related Mitochondrial Disease: An Under-Recognised and Under-Treated Clinical Entity (P5.262)', Neurology, 86, http://dx.doi.org/10.1212/wnl.86.16_supplement.p5.262

Journal articles | 2016

Rygiel KA; Tuppen HA; Grady JP; Vincent A; Blakely EL; Reeve AK; Taylor RW; Picard M; Miller J; Turnbull DM, 2016, 'Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis.', Nucleic Acids Res, 44, pp. 5313 - 5329, http://dx.doi.org/10.1093/nar/gkw382

Journal articles | 2016

Vincent AE; Grady JP; Rocha MC; Alston CL; Rygiel KA; Barresi R; Taylor RW; Turnbull DM, 2016, 'Mitochondrial dysfunction in myofibrillar myopathy.', Neuromuscul Disord, 26, pp. 691 - 701, http://dx.doi.org/10.1016/j.nmd.2016.08.004

Journal articles | 2016

Vincent AE; Rosa HS; Alston CL; Grady JP; Rygiel KA; Rocha MC; Barresi R; Taylor RW; Turnbull DM, 2016, 'Dysferlin mutations and mitochondrial dysfunction.', Neuromuscul Disord, 26, pp. 782 - 788, http://dx.doi.org/10.1016/j.nmd.2016.08.008

Journal articles | 2015

Gorman GS; Grady JP; Turnbull DM, 2015, 'Mitochondrial donation--how many women could benefit?', N Engl J Med, 372, pp. 885 - 887, http://dx.doi.org/10.1056/NEJMc1500960

Journal articles | 2015

Ng YS; Gorman G; Nesbitt V; Pitceathly R; Grady J; Schaefer A; Bright A; Feeney C; Rahman S; Poulton J; Taylor R; Hanna M; Turnbull D; McFarland R, 2015, 'Phenotypes and Genotypes of Mitochondrial Disease- Findings from A National Mitochondrial Disease Cohort (P2.061)', Neurology, 84, http://dx.doi.org/10.1212/wnl.84.14_supplement.p2.061

Journal articles | 2015

Rocha MC; Grady JP; Grünewald A; Vincent A; Dobson PF; Taylor RW; Turnbull DM; Rygiel KA, 2015, 'A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis.', Sci Rep, 5, pp. 15037, http://dx.doi.org/10.1038/srep15037

Journal articles | 2015

Rygiel KA; Grady JP; Taylor RW; Tuppen HAL; Turnbull DM, 2015, 'Triplex real-time PCR--an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells.', Sci Rep, 5, pp. 9906, http://dx.doi.org/10.1038/srep09906

Journal articles | 2015

Rygiel KA; Miller J; Grady JP; Rocha MC; Taylor RW; Turnbull DM, 2015, 'Mitochondrial and inflammatory changes in sporadic inclusion body myositis.', Neuropathol Appl Neurobiol, 41, pp. 288 - 303, http://dx.doi.org/10.1111/nan.12149

Journal articles | 2015

Vincent A; Rocha M; Rygiel K; Grady J; Campbell G; Barresi R; Taylor R; Turnbull D, 2015, 'Mitochondrial dysfunction: A key player in myofibrillar myopathy?', Neuromuscular Disorders, 25, pp. S257 - S257, http://dx.doi.org/10.1016/j.nmd.2015.06.260

Journal articles | 2015

Yu-Wai-Man P; Gorman GS; Schaefer AM; Grady JP; Ng Y; Chinnery PF; Taylor RW; McFarland R; Turnbull DM, 2015, 'The prevalence of mitochondrial disease in the adult population', Mitochondrion, 24, pp. S16 - S17, http://dx.doi.org/10.1016/j.mito.2015.07.051

Journal articles | 2014

Grady JP; Campbell G; Ratnaike T; Blakely EL; Falkous G; Nesbitt V; Schaefer AM; McNally RJ; Gorman GS; Taylor RW; Turnbull DM; McFarland R, 2014, 'Disease progression in patients with single, large-scale mitochondrial DNA deletions.', Brain, 137, pp. 323 - 334, http://dx.doi.org/10.1093/brain/awt321

Journal articles | 2014

Grady JP; Murphy JL; Blakely EL; Haller RG; Taylor RW; Turnbull DM; Tuppen HAL, 2014, 'Accurate measurement of mitochondrial DNA deletion level and copy number differences in human skeletal muscle.', PLoS One, 9, pp. e114462, http://dx.doi.org/10.1371/journal.pone.0114462

Journal articles | 2014

Ng YS; Lax N; Gorman G; Schaefer A; Taylor R; Grady J; Turnbull D; McFarland R, 2014, 'P27 Sudden unexpected death in adults with m.3243A>G mutation', Neuromuscular Disorders, 24, pp. S14 - S14, http://dx.doi.org/10.1016/s0960-8966(14)70043-4

Journal articles | 2014

Rygiel KA; Grady JP; Turnbull DM, 2014, 'Respiratory chain deficiency in aged spinal motor neurons.', Neurobiol Aging, 35, pp. 2230 - 2238, http://dx.doi.org/10.1016/j.neurobiolaging.2014.02.027

Journal articles | 2012

Greaves LC; Elson JL; Nooteboom M; Grady JP; Taylor GA; Taylor RW; Mathers JC; Kirkwood TBL; Turnbull DM, 2012, 'Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations', Plos Genetics, 8, http://dx.doi.org/10.1371/journal.pgen.1003082

Journal articles | 2012

Serrano-Pedraza I; Grady JP; Read JCA, 2012, 'Spatial frequency bandwidth of surround suppression tuning curves.', J Vis, 12, http://dx.doi.org/10.1167/12.6.24

Journal articles | 2011

Hennig MH; Grady J; van Coppenhagen J; Sernagor E, 2011, 'Age-dependent homeostatic plasticity of GABAergic signaling in developing retinal networks.', J Neurosci, 31, pp. 12159 - 12164, http://dx.doi.org/10.1523/JNEUROSCI.3112-11.2011

Journal articles | 2011

Serrano-Pedraza I; Grady JP; Read JCA, 2011, 'Spatial frequency bandwidth of surround suppression', Journal of Vision, 11, pp. 1177 - 1177, http://dx.doi.org/10.1167/11.11.1177
Conference Papers | 2025

Harris S; Gaughran G; Napier C; Yap M; Grady J; Caillet V; Ballinger M; Kee D; Thavaneswaran S; Davies A; Southi N; Thomas D, 2025, 'KRAS Mutations in Australian Gastrointestinal Cancer Patients: An Analysis of the Molecular Screening and Therapeutics (MoST) Program', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY

Conference Papers | 2025

Pavlakis N; Lee CK; Ballinger ML; Brown CSB; Grady JP; Lin F; Thavaneswaran S; Mersiades AJ; Zhou DD-X; Lee J; John T; Napier CE; Cummins MM; Collignon E; Sebastian L; Turnbull OMH; Simes J; Thomas DM; Solomon BJ, 2025, 'ASPiRATION. Australian Nationwide Cohort Study to Assess Impact of Comprehensive Genomic Profiling in Metastatic Lung Cancer', in JOURNAL OF THORACIC ONCOLOGY, ELSEVIER SCIENCE INC

Conference Abstracts | 2025

Southi N; Sim H-W; Grady J; Satgunaseelan L; Huang M; Kansara M; Yuile A; Zaman A; Lin F; Wheeler H; Hudson A; Ballinger ML; Thomas DM; Thavaneswaran S, 2025, 'Understanding the prevalence ofMTAP andCDKN2A/B deletion in gliomas by next generation sequencing', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 27, pp. v252 - v252, http://dx.doi.org/10.1093/neuonc/noaf201.1004

Conference Abstracts | 2025

Thavaneswaran S; Espinoza D; Lin FP; Chinchen S; Kansara M; Ballinger M; Grady J; Grimison P; Millward M; Ladwa R; Joshua AM; Desai J; Simes J; Thomas D, 2025, 'Phase II trial of Vismodegib in advanced cancers with Hedgehog pathway alterations', in ANNALS OF ONCOLOGY, ELSEVIER, GERMANY, Berlin, Vol. 36, presented at Annual Meeting of the European-Society-for-Medical-Oncology (ESMO), GERMANY, Berlin, 17 October 2025 - 21 October 2025, http://dx.doi.org/10.1016/j.annonc.2025.08.1542

Preprints | 2025

Tran M; Chan JC; Huang ML; Kansara M; Grady JP; Napier CE; Thavaneswaran S; Ballinger ML; Thomas DM; Lin FP, 2025, A Robust BERT-Based Deep Learning Model for Automated Cancer Type Extraction from Unstructured Pathology Reports, http://dx.doi.org/10.48550/arxiv.2508.15149

Conference Papers | 2024

Harris S; Caillet V; Davies A; Gaughran G; Napier C; Lin F; Simes J; Grady J; Balinger M; Thomas D, 2024, 'Prevalence and co-mutation status of MTAP deletions', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 116 - 116

Preprints | 2024

Jung M; Poltavets V; Skhinas J; Tax G; Kamili A; Xie AJ; Ghamrawi S; Graber P; Mao J; Wong-Erasmus M; Cui L; Kimpton K; Venkat P; Mayoh C; Fleuren E; Fordham A; Barger Z; Grady J; Thomas D; Du EY; Cowley M; Gifford A; Fletcher J; Lau L; Dolman E; Gooding J; Kavallaris M, 2024, Engineered paediatric tumours retain maintains tumour genotype and phenotype for precision medicine, http://dx.doi.org/10.1101/2024.11.17.619539

Conference Abstracts | 2024

Lin FP-Y; Grady JP; Napier CE; Callow M; Thavaneswaran S; Huang ML; Zaheed M; Kansara M; Sebastian L; Ballinger ML; Simes J; Thomas DM, 2024, 'Impact of artificial intelligence (AI) decision support on clinical trial participation: A before-after implementation study on a nationwide molecular tumor board', in Journal of Clinical Oncology, American Society of Clinical Oncology, Vol. 42, presented at 2024 ASCO Annual Meeting I, 29 May 2024 - 29 May 2024, http://dx.doi.org/10.1200/JCO.2024.42.16_suppl.1557

Conference Abstracts | 2024

Lin FPY; Grady JP; Napier CE; Callow M; Thavaneswaran S; Huang ML; Zaheed M; Kansara M; Sebastian L; Ballinger ML; Simes J; Thomas DM, 2024, 'Impact of artificial intelligence (AI) decision support on clinical trial participation: A before-after implementation study on a nationwide molecular tumor board.', in Journal of Clinical Oncology, Vol. 42, pp. 1557 - 1557, http://dx.doi.org/10.1200/JCO.2024.42.16_suppl.1557

Conference Abstracts | 2024

Zaheed M; Grady JP; Murrow B; Douglas B; Carpenter E; Mckay S; Liang S; Taylor N; Lin FP-Y; Goldstein D; Tucker K; Thomas DM; Ballinger ML, 2024, 'Translating potential germline findings from tumour profiling into routine clinical care.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, JAPAN, Yokohama, Vol. 42, pp. 105 - 105, presented at ASCO Breakthrough: A Global Summit for Oncology Innovators, JAPAN, Yokohama, 08 August 2024 - 10 August 2024, http://dx.doi.org/10.1200/JCO.2024.42.23_suppl.105

Conference Abstracts | 2023

Kansara M; Lin FP-Y; Thavaneswaran S; Napier CE; Grady JP; Ballinger ML; Simes J; Thomas DM, 2023, 'Genomic alterations associated with response to immune checkpoint inhibitors in rare cancers: A biomarker exploration study from the Australian Molecular Screening and Therapeutics (MoST) Program', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 41, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Conference Abstracts | 2023

Lin FP-Y; Thavaneswaran S; Napier CE; Grady JP; Kansara M; Sebastian L; Kee D; Zaheed M; Millward M; Brown MP; Charakidis M; Craft PS; Grimison PS; Harrup RA; O'Byrne KJ; Desai J; Lee CK; Ballinger ML; Simes J; Thomas DM, 2023, 'Genomic therapy matching in rare and refractory cancers: Updated results from a retrospective cohort study in the Molecular Screening and Therapeutic (MoST) program', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 41, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Conference Abstracts | 2023

Thavaneswaran S; Lin FP-Y; Napier CE; Grady JP; Ballinger ML; Kansara M; Grimison PS; Pavlakis N; Wong MK; Sjoquist KM; Goldstein D; Chantrill LA; Simes J; Thomas DM, 2023, 'Genomic targetability and survival outcomes of biliary tract cancers (BTC): A retrospective cohort study of the Australian Molecular Screening and Therapeutics (MoST) program', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 41, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Conference Abstracts | 2023

Thavaneswaran S; Mersiades A; Lin FP-Y; Espinoza D; Grady JP; Lee CK; Desai J; Brown MP; Grimison PS; O'Byrne KJ; Harrup RA; Nagrial A; Sebastian L; Chinchen S; Kansara M; Craft PS; Simes MMJ; Joshua AM; Thomas DM, 2023, 'Trastuzumab emtansine (T-DM1) in advanced cancers with HER2 mutations or amplification: Results from the Molecular Screening and Therapeutics (MoST) Program substudy.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 41, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Conference Abstracts | 2022

Lin FP-Y; Thavaneswaran S; Grady JP; Napier CE; Kansara M; Sebastian L; Kee D; Oakes SR; Blackburn J; Scott HS; Glover A; Fox SB; Goldstein D; Leo P; Amanuel B; Desai J; Lee CK; Ballinger ML; Simes J; Thomas DM, 2022, 'Molecular therapy selection in treatment-refractory advanced cancers: A retrospective cohort study determining the utility of TOPOGRAPH knowledge base.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 40, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 03 June 2022 - 07 June 2022

Conference Abstracts | 2022

Lin FP-Y; Thavaneswaran S; Grady JP; Napier CE; Kansara M; Sebastian L; Kee D; Oakes SR; Blackburn J; Scott HS; Glover A; Fox SB; Goldstein D; Leo P; Amanuel B; Desai J; Lee CK; Ballinger ML; Simes J; Thomas DM, 2022, 'Molecular therapy selection in treatment-refractory advanced cancers: A retrospective cohort study determining the utility of TOPOGRAPH knowledge base.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, pp. 3073 - 3073, http://dx.doi.org/10.1200/jco.2022.40.16_suppl.3073

Preprints | 2022

Thavaneswaran S; Lin F; Kansara M; Grady J; Espinoza D; Joshua A; Grimison P; Craft P; Cosman R; Lee C; Harwood K; Chinchen S; Corpuz T; Ballinger M; Sebastian L; Simes J; Thomas D, 2022, A signal-seeking Phase II trial of Durvalumab and Tremelimumab Focused on Advanced, Rare and Less Common Cancers, http://dx.doi.org/10.1101/2022.06.30.22277092

Conference Abstracts | 2021

Mueller SA; Gauthier M-EA; Blackburn J; Grady JP; Kratisek S; Dettmer MS; Dahlstrom JE; Lee CS; Luk P; Yu B; Giger R; Kummerfeld S; Clark J; Gupta R; Cowley MJ, 2021, 'Molecular patterns in salivary duct carcinoma identify prognostic subgroups', in ORAL ONCOLOGY, ELSEVIER, Vol. 118, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000669389300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2021

Thavaneswaran S; Sebastian L; Finlayson S; Desai J; O'Byrne K; Harrup R; Ballinger ML; Lin F; Grady JP; Kansara M; Simes J; Leland SM; Jansen VM; Cavers AC; Thomas DM, 2021, 'CRESTONE: Clinical Study of REsponse to Seribantumab in Tumours with NEuregulin-1 (NRG1) Fusions: A phase 2 study of the anti-HER3 monoclonal antibody for advanced or metastatic solid tumours (MoST CRESTONE in Australia)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 17, pp. 206 - 206, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000717281500346&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2021

Thavaneswaran S; Sebastian L; Kansara M; Ballinger M; Espinoza D; Lin F; Lee C; Sjoquist K; Grady J; Cowley M; Joshua A; Qiu M; Oakes S; Simes J; Thomas D, 2021, A Signal-seeking Phase Iia Trial of Palbociclib in Advanced Cancers With Cell Cycle Pathway Alterations – A Substudy of the Molecular Screening and Therapeutics (Most) Program, http://dx.doi.org/10.21203/rs.3.rs-254137/v1

Conference Abstracts | 2020

Joshua AM; Prawira A; Thavaneswaran S; Cosman R; Lee CK; Sjoquist KM; Simes J; Thomas DM; Espinoza D; Sebastian L; Ballinger ML; Hague W; Chinchen S; Collignon E; Kansara M; Palacios T; Grady J; Barker H; Thornton K, 2020, 'A signal-seeking trial of olaparib and durvalumab in homologous repair-deficient tumors: A sub-study of the cancer molecular screening and therapeutics (MoST) program.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 38, presented at Annual Scientific Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 29 May 2020 - 02 June 2020

Preprints | 2020

Lin F; Thavaneswaran S; Grady J; Ballinger M; Kansara M; Oakes S; Desai J; Lee CK; Simes J; Thomas D, 2020, Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology, http://dx.doi.org/10.1101/2020.12.18.20248521

Conference Abstracts | 2019

Thavaneswaran S; Ballinger ML; Grady J; Cowley M; Joshua A; Sebastian L; Collignon E; Silvestri A; Kansara M; Pinese M; Sjoquist KM; Hague W; Lee CK; Simes J; Thomas DM, 2019, 'The Cancer Molecular Screening and Therapeutics Program (MoST): Actionable mutation frequencies in a population with rare and less common cancers.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 37, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2019 - 04 June 2019, http://dx.doi.org/10.1200/JCO.2019.37.15_suppl.3136

Conference Abstracts | 2018

Thavaneswaran S; Sebastian L; Ballinger M; Cowley M; Grady J; Joshua A; Lee C; Sjoquist K; Hague W; Simes J; Thomas D, 2018, 'The cancer molecular screening and therapeutics program (MoST): A molecular screening platform with multiple, parallel, signal-seeking therapeutic substudies', in Annals of oncology : official journal of the European Society for Medical Oncology, Vol. 29, pp. viii147, http://dx.doi.org/10.1093/annonc/mdy279.434

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