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Emeritus Professor John Whitelock
Emeritus Professor

Emeritus Professor John Whitelock

Engineering
Grad Sch: Biomedical Eng

Research Interests:
Tissue repair and regeneration involves interactions between the extracellular environment that binds growth signals and guides cell and tissue behavior. The activity of these signals is controlled by glycosylated molecules known as proteoglycans and this is my central area of research interest.

Broad Research Areas:
Biochemistry, Biomedical Engineering, Cell Biology and Gene Regulation, Cardiology and Vascular Disease, Proteomics

Society Memberships & Professional Activities:
International Society for Matrix Biology, American Society for Matrix Biology, Australian and New Zealand Society for Matrix Biology - President, Australian Society for Medical Research

Specific Research Keywords:
Glycomics, Mass Spectrometry, Proteoglycans, Tissue Regeneration, mast cell biology
Mobile
0408162115
Phone
+61-2-9385-3948
E-mail
j.whitelock@unsw.edu.au
Location
Graduate School of Biomedical Engineering Level 5, Samuels Bldg University of New South Wales Sydney, Australia, 2052
  • Book Chapters | 2015
    Vassie JA; Whitelock JM; Lord MS, 2015, 'Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions', in Methods in Molecular Biology, pp. 557 - 565, http://dx.doi.org/10.1007/978-1-4939-1714-3_44
    Book Chapters | 2009
    2009, 'Small-Scale Enzymatic Digestion of Glycoproteins and Proteoglycans for Analysis of Oligosaccharides by LC-MS and FACE Gel Electrophoresis', in Parker NH; Karlsson NG (ed.), Glycomics: Methods and Protocols (Methods in Molecular Biology), Volume 534, Humana Press, Inc, United States, pp. 171 - 192, http://dx.doi.org/10.1007/978-1-59745-022-5_13
    Book Chapters | 2006
    Melrose J; Whitelock J, 2006, 'Extracellular Matrix', in Metin Akay (ed.), Wiley Encyclopedia of Biomedical Engineering, edn. 1, John Wiley & Sons, USA, pp. 1556 - 1577
    Book Chapters | 2006
    Whitelock J; Melrose J, 2006, 'Adhesion of cells to biomaterials', in Metin Akay (ed.), Wiley Encyclopedia of Biomedical Engineering, edn. 1, John Wiley & Sons, USA, pp. 16 - 23
    Book Chapters | 2001
    2001, 'Purification of Perlecan from Endothelial Cells', in Proteoglycan Protocols, Springer Nature, pp. 27 - 34, http://dx.doi.org/10.1385/1-59259-209-0:027
  • Journal articles | 2023
    Lau K; Fu L; Zhang A; Akhavan B; Whitelock J; Bilek MM; Lord MS; Rnjak-Kovacina J, 2023, 'Recombinant perlecan domain V covalently immobilized on silk biomaterials via plasma immersion ion implantation supports the formation of functional endothelium', Journal of Biomedical Materials Research - Part A, 111, pp. 825 - 839, http://dx.doi.org/10.1002/jbm.a.37525
    Journal articles | 2023
    2023, 'A Biomolecular Toolbox for Precision Nanomotors', Advanced Materials, 35, pp. e2205746, http://dx.doi.org/10.1002/adma.202205746
    Journal articles | 2022
    2022, 'Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma', Cancers, 14, http://dx.doi.org/10.3390/cancers14225564
    Journal articles | 2022
    2022, 'Editorial: Roles of Chondroitin Sulfate and Dermatan Sulfate as Regulators for Cell and Tissue Development', Frontiers in Cell and Developmental Biology, 10, pp. 941178, http://dx.doi.org/10.3389/fcell.2022.941178
    Journal articles | 2022
    2022, 'ROS-Mediated Anti-Angiogenic Activity of Cerium Oxide Nanoparticles in Melanoma Cells', ACS Biomaterials Science and Engineering, 8, pp. 512 - 525, http://dx.doi.org/10.1021/acsbiomaterials.1c01268
    Journal articles | 2022
    2022, 'Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis', International Journal of Molecular Sciences, 23, pp. 1934 - 1934, http://dx.doi.org/10.3390/ijms23041934
    Journal articles | 2022
    2022, 'Surface Biofunctionalization of Silk Biomaterials Using Dityrosine Cross-Linking', ACS Applied Materials and Interfaces, 14, pp. 31551 - 31566, http://dx.doi.org/10.1021/acsami.2c03345
    Journal articles | 2022
    2022, 'Tuning the intentional corona of cerium oxide nanoparticles to promote angiogenesis via fibroblast growth factor 2 signalling', Regenerative Biomaterials, 9, http://dx.doi.org/10.1093/rb/rbac081
    Journal articles | 2021
    Ng CY; Whitelock JM; Williams H; Kim HN; Medbury HJ; Lord MS, 2021, 'Macrophages bind LDL using heparan sulfate and the perlecan protein core', Journal of Biological Chemistry, 296, pp. 100520, http://dx.doi.org/10.1016/j.jbc.2021.100520
    Journal articles | 2021
    2021, 'Biomimetic silk biomaterials: Perlecan-functionalized silk fibroin for use in blood-contacting devices', Acta Biomaterialia, 132, pp. 162 - 175, http://dx.doi.org/10.1016/j.actbio.2021.02.014
    Journal articles | 2021
    2021, 'Effect of Recombinant Human Perlecan Domain V Tethering Method on Protein Orientation and Blood Contacting Activity on Polyvinyl Chloride', Advanced Healthcare Materials, 10, http://dx.doi.org/10.1002/adhm.202100388
    Journal articles | 2021
    2021, 'pH-Gated Activation of Gene Transcription and Translation in Biocatalytic Metal-Organic Framework Artificial Cells', ADVANCED NANOBIOMED RESEARCH, 1, http://dx.doi.org/10.1002/anbr.202000034
    Journal articles | 2020
    2020, 'A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials', Adv. Sci., 7, pp. 2000900, http://dx.doi.org/10.1002/advs.202000900
    Journal articles | 2020
    2020, 'Better growth-factor binding aids tissue repair', Nature Biomedical Engineering, 4, pp. 368 - 369, http://dx.doi.org/10.1038/s41551-020-0548-3
    Journal articles | 2020
    2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, 9, http://dx.doi.org/10.3389/fonc.2019.01482
    Journal articles | 2020
    2020, 'Microchannels are an architectural cue that promotes integration and vascularization of silk biomaterials in vivo', ACS Biomaterials Science and Engineering, 6, pp. 1476 - 1486, http://dx.doi.org/10.1021/acsbiomaterials.9b01624
    Journal articles | 2020
    2020, 'The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology', Journal of Histochemistry and Cytochemistry, 68, pp. 907 - 927, http://dx.doi.org/10.1369/0022155420940067
    Journal articles | 2019
    2019, 'Decreased placental glypican expression is associated with human fetal growth restriction', Placenta, 76, pp. 6 - 9, http://dx.doi.org/10.1016/j.placenta.2018.12.007
    Journal articles | 2019
    2019, 'Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms', Journal of Biological Chemistry, 294, pp. 11458 - 11472, http://dx.doi.org/10.1074/jbc.RA119.008647
    Journal articles | 2018
    Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2018, 'The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies', Journal of Histochemistry and Cytochemistry, 66, pp. 321 - 336, http://dx.doi.org/10.1369/0022155417740881
    Journal articles | 2018
    Farrugia BL; Lord MS; Whitelock JM; Melrose J, 2018, 'Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair', Biomaterials Science, 6, pp. 947 - 957, http://dx.doi.org/10.1039/c7bm01158j
    Journal articles | 2018
    Hayes A; Sugahara K; Farrugia B; Whitelock JM; Caterson B; Melrose J, 2018, 'Biodiversity of CS–proteoglycan sulphation motifs: Chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis', Biochemical Journal, 475, pp. 587 - 620, http://dx.doi.org/10.1042/BCJ20170820
    Journal articles | 2018
    Lord MS; Tang F; Rnjak-Kovacina J; Smith JG W; Melrose J; Whitelock JM, 2018, 'The multifaceted roles of perlecan in fibrosis', Matrix Biology, 68-69, pp. 150 - 166, http://dx.doi.org/10.1016/j.matbio.2018.02.013
    Journal articles | 2018
    Vassie JA; Whitelock JM; Lord MS, 2018, 'Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells', Molecular Pharmaceutics, 15, pp. 994 - 1004, http://dx.doi.org/10.1021/acs.molpharmaceut.7b00920
    Journal articles | 2018
    2018, 'Cell surface chondroitin sulfate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulfate proteoglycan, perlecan, and is involved in cell adhesion', The Journal of Biochemistry, 163, pp. 399 - 412, http://dx.doi.org/10.1093/jb/mvy008
    Journal articles | 2018
    2018, 'Chitosan‐Based Heparan Sulfate Mimetics Promote Epidermal Formation in a Human Organotypic Skin Model', Advanced Functional Materials, 28, http://dx.doi.org/10.1002/adfm.201802818
    Journal articles | 2018
    2018, 'Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives', Advanced Healthcare Materials, 7, pp. 1701042 - 1701042, http://dx.doi.org/10.1002/adhm.201701042
    Journal articles | 2017
    Chui A; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Van Zanten DE; Eijsink J; Wang Y; Deane J; Borg AJ; Stevenson J; Erwich JJ; Said JM; Murthi P, 2017, 'Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, 37, pp. 1168 - 1179, http://dx.doi.org/10.1161/ATVBAHA.117.309422
    Journal articles | 2017
    Kim HN; Whitelock JM; Lord MS, 2017, 'Structure-activity relationships of bioengineered heparin/heparan sulfates produced in different bioreactors', Molecules, 22, http://dx.doi.org/10.3390/molecules22050806
    Journal articles | 2017
    Krilis M; Qi M; Madigan MC; Wong JW H; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940
    Journal articles | 2017
    Lord MS; Cheng B; Farrugia BL; McCarthy S; Whitelock JM, 2017, 'Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation', Journal of Biological Chemistry, 292, pp. 4054 - 4063, http://dx.doi.org/10.1074/jbc.M116.760660
    Journal articles | 2017
    Lord MS; Ellis AL; Farrugia BL; Whitelock JM; Grenett H; Li C; O'Grady RL; DeCarlo AA, 2017, 'Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing', Journal of Controlled Release, 250, pp. 48 - 61, http://dx.doi.org/10.1016/j.jconrel.2017.02.009
    Journal articles | 2017
    Lord MS; Jung MS; Whitelock JM, 2017, 'Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications', Bioengineered, 8, pp. 661 - 664, http://dx.doi.org/10.1080/21655979.2017.1301328
    Journal articles | 2017
    Rnjak-Kovacina J; Tang F; Lin X; Whitelock JM; Lord MS, 2017, 'Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan', Biotechnology Journal, 12, http://dx.doi.org/10.1002/biot.201700196
    Journal articles | 2017
    Vassie JA; Whitelock JM; Lord MS, 2017, 'Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells', Acta Biomaterialia, 50, pp. 127 - 141, http://dx.doi.org/10.1016/j.actbio.2016.12.010
    Journal articles | 2017
    2017, 'Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins', Blood Advances, 1, pp. 1243 - 1253, http://dx.doi.org/10.1182/bloodadvances.2017004333
    Journal articles | 2016
    Dos Santos M; Michopoulou A; André-Frei V; Boulesteix S; Guicher C; Dayan G; Whitelock J; Damour O; Rousselle P, 2016, 'Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin', Aging, 8, pp. 751 - 768, http://dx.doi.org/10.18632/AGING.100928
    Journal articles | 2016
    Farrugia BL; Whitelock JM; O’Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 64, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649
    Journal articles | 2016
    Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity', Metabolic Engineering, 38, pp. 105 - 114, http://dx.doi.org/10.1016/j.ymben.2016.07.006
    Journal articles | 2016
    Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008
    Journal articles | 2016
    Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications', Colloids and Surfaces B: Biointerfaces, 148, pp. 130 - 138, http://dx.doi.org/10.1016/j.colsurfb.2016.08.039
    Journal articles | 2016
    Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis and Rheumatology, 68, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529
    Journal articles | 2016
    2016, 'Bioengineering Proteoglycan‐based Matrices For Blood Contacting Applications', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.622.2
    Journal articles | 2016
    2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research - Part A, 104, pp. 1736 - 1746, http://dx.doi.org/10.1002/jbm.a.35704
    Journal articles | 2016
    2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, 32, pp. 40 - 57, http://dx.doi.org/10.22203/eCM.v032a03
    Journal articles | 2016
    2016, 'Peroxynitrite Modifies Components of the Extracellular Matrix of Human Atherosclerotic Lesions', Free Radical Biology and Medicine, 100, pp. S139 - S139, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.364
    Journal articles | 2016
    2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, 11, pp. 029701 - 029701, http://dx.doi.org/10.1116/1.4952450
    Journal articles | 2015
    Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, 20, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254
    Journal articles | 2015
    Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, 15, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158
    Journal articles | 2015
    Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, 20, pp. 121 - 131, http://dx.doi.org/10.1007/s10911-015-9346-z
    Journal articles | 2015
    2015, 'The Potent Inflammatory Oxidant, Peroxynitrite, Modifies the Extracellular Matrix of Human Atherosclerotic Lesions', Free Radical Biology and Medicine, 87, pp. S145 - S146, http://dx.doi.org/10.1016/j.freeradbiomed.2015.10.374
    Journal articles | 2014
    Baljinnyam E; Umemura M; Chuang C; De Lorenzo MS; Iwatsubo M; Chen S; Goydos JS; Ishikawa Y; Whitelock JM; Iwatsubo K, 2014, 'Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling', Pigment Cell and Melanoma Research, 27, pp. 611 - 620, http://dx.doi.org/10.1111/pcmr.12250
    Journal articles | 2014
    Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2014, 'Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells', Biochemical Journal, 459, pp. 313 - 322, http://dx.doi.org/10.1042/BJ20131471
    Journal articles | 2014
    Chui A; Murthi P; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Said JM, 2014, 'Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?', Placenta, 35, pp. 596 - 605, http://dx.doi.org/10.1016/j.placenta.2014.05.009
    Journal articles | 2014
    Farrugia BL; Whitelock JM; Jung M; O'Grady RL; McGrath B; McCarthy SJ; Lord MS, 2014, 'The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan', Biomaterials, 35, pp. 1462 - 1477, http://dx.doi.org/10.1016/j.biomaterials.2013.10.068
    Journal articles | 2014
    Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, 20, pp. 6517 - 6526, http://dx.doi.org/10.1039/c4tb00531g
    Journal articles | 2014
    Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases, 9, pp. 041002, http://dx.doi.org/10.1116/1.4900993
    Journal articles | 2014
    2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, 5, pp. 222 - 226, http://dx.doi.org/10.4161/bioe.29388
    Journal articles | 2014
    2014, 'The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling', Matrix Biology, 35, pp. 112 - 122, http://dx.doi.org/10.1016/j.matbio.2014.01.016
    Journal articles | 2014
    2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, 35, pp. 123 - 131, http://dx.doi.org/10.1016/j.matbio.2013.12.005
    Journal articles | 2013
    Chuang CY; Degendorfer G; Hammer A; Malle E; Kawasaki H; Yamakura F; Whitelock JM; Davies MJ, 2013, 'Peroxynitrite-mediated damage in the artery wall and its consequences', FREE RADICAL BIOLOGY AND MEDICINE, 65, pp. S6 - S6, http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.117
    Journal articles | 2013
    2013, 'The functional effect of Syndecan 1 deficiency in BeWo cells and its implications in fetal growth restriction', Placenta, 34, pp. A67 - A67, http://dx.doi.org/10.1016/j.placenta.2013.06.201
    Journal articles | 2013
    2013, 'Unfractionated heparin reverses the increased thrombin generation associated with decorin deficiency in fetal growth restriction', Placenta, 34, pp. A25 - A26, http://dx.doi.org/10.1016/j.placenta.2013.06.078
    Journal articles | 2012
    2012, 'Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity', The Journal of Biological Chemistry, 287, pp. 35922 - 35933, http://dx.doi.org/10.1074/jbc.M112.363119
    Journal articles | 2012
    2012, 'Not all lubricin isoforms are substituted with a glycosaminoglycan chain', Connective Tissue Research, 53, pp. 132 - 141, http://dx.doi.org/10.3109/03008207.2011.614364
    Journal articles | 2012
    2012, 'Syndecan-4 is associated with betá-cells in the pancreas and the MIN6 beta-cell line', Histochemistry and Cell Biology, 138, pp. 933 - 944, http://dx.doi.org/10.1007/s00418-012-1004-6
    Journal articles | 2011
    2011, 'Endorepellin, the angiostatic module of perlecan, interacts with both the á2â1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): A dual receptor antagonism', The Journal of Biological Chemistry, 286, pp. 25947 - 25962, http://dx.doi.org/10.1074/jbc.M111.243626
    Journal articles | 2011
    2011, 'Heparan sulfate proteoglycans in healthy and diseased systems', Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 3, pp. 739 - 751, http://dx.doi.org/10.1002/wsbm.149
    Journal articles | 2011
    2011, 'Matrix components and scaffolds for sustained islet function', Tissue Engineering Part B: Reviews, 17, pp. 235 - 247, http://dx.doi.org/10.1089/ten.teb.2011.0004
    Journal articles | 2011
    2011, 'Mechanisms and consequences of oxidative damage to extracellular matrix', Biochemical Society Transactions, 39, pp. 1279 - 1287, http://dx.doi.org/10.1042/BST0391279
    Journal articles | 2010
    Ellis AL; Ellis AL; Yang G; Jones K; Chuang CY; Whitelock J; DeCarlo AA, 2010, 'Similarity of Recombinant Human Perlecan', BMC Biotechnology, pp. 1 - 12
    Journal articles | 2010
    Ellis AL; Pan W; Yang G; Jones K; Chuang C; Whitelock JM; DeCarlo AA, 2010, 'Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1', BMC Biotechnology, 10, http://dx.doi.org/10.1186/1472-6750-10-66
    Journal articles | 2010
    Estrella RP; Whitelock J; Packer NH; Karlsson NG, 2010, 'The glycosylation of human synovial lubricin:', Biochemical Journal, 429, pp. 359 - 367
    Journal articles | 2010
    Estrella RP; Whitelock JM; Packer NH; Karlsson NG, 2010, 'The glycosylation of human synovial lubricin: Implications for its role in inflammation', Biochemical Journal, 429, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20100360
    Journal articles | 2010
    Kennett EC; Rees MD; Malle E; Hammer A; Whitelock JM; Davies MJ, 2010, 'Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains', Free Radical Biology and Medicine, 49, pp. 282 - 293, http://dx.doi.org/10.1016/j.freeradbiomed.2010.04.018
    Journal articles | 2010
    Kennett EC; Rees MD; Mallee E; Hammer A; Whitelock J; Davies MJ, 2010, 'Peroxynitrite modifies the structure and function of the extracellular matrix', Free Radical Biology and Medicine, 49, pp. 282 - 293
    Journal articles | 2010
    2010, 'LTBP-2 has multiple heparin/heparan sulfate binding sites', Matrix Biology, 29, pp. 393 - 401, http://dx.doi.org/10.1016/j.matbio.2010.03.005
    Journal articles | 2009
    Lord MS; Yu W; Cheng B; Simmons A; Poole-Warren LA; Whitelock J, 2009, 'The modulation of platelet and endothelial cell adhesion to vascular graft materials by perlecan', Biomaterials, 30, pp. 4898 - 4906, http://dx.doi.org/10.1016/j.biomaterials.2009.05.063
    Journal articles | 2009
    Rees MD; Whitelock J; Malle E; Chuang CY; Iozzo R; Nilasaroya A; Davies MJ, 2009, 'Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan', Matrix Biology, pp. 1 - 11
    Journal articles | 2009
    2009, 'Enhanced tumor growth in the NaS1 sulfate transporter null mouse', Cancer Science, 101, pp. 369 - 373, http://dx.doi.org/10.1111/j.1349-7006.2009.01399.x
    Journal articles | 2009
    2009, 'Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides', Biochemical Journal, 421, pp. 79 - 86, http://dx.doi.org/10.1042/bj20090309
    Journal articles | 2009
    2009, 'Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis', Matrix Biology, 28, pp. 284 - 291, http://dx.doi.org/10.1016/j.matbio.2009.04.010
    Journal articles | 2009
    2009, 'Proteomics makes progress in cartilage and arthritis research', Matrix Biology, 28, pp. 121 - 128, http://dx.doi.org/10.1016/j.matbio.2009.01.004
    Journal articles | 2009
    2009, 'Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development', Histochemistry and Cell Biology, 132, pp. 491 - 503, http://dx.doi.org/10.1007/s00418-009-0623-z
    Journal articles | 2008
    2008, 'A central function for perlecan in skeletal muscle and cardiovascular development', Journal of Cell Biology, 181, pp. 381 - 394, http://dx.doi.org/10.1083/jcb.200708022
    Journal articles | 2008
    2008, 'Characterisation of redox initiators for producing poly (vinyl alcohol)hydrogels', Macromolecular Symposia, 266, pp. 59 - 62, http://dx.doi.org/10.1002/masy.200850611
    Journal articles | 2008
    2008, 'Characterization and purification of glycosaminoglycans from crude biological samples', Journal of Agricultural and Food Chemistry, 56, pp. 343 - 348, http://dx.doi.org/10.1021/jf072624v
    Journal articles | 2008
    2008, 'Diverse cell signalling events modulated by perlecan', Biochemistry, 47, pp. 11174 - 11183, http://dx.doi.org/10.1021/bi8013938
    Journal articles | 2008
    2008, 'Oxidative damage to extracellular matrix and its role in human pathologies', Free Radical Biology and Medicine, 44, pp. 1973 - 2001, http://dx.doi.org/10.1016/j.freeradbiomed.2008.03.016
    Journal articles | 2008
    2008, 'Perlecan, the `jack of all trades` proteoglycan of cartilaginous weight-bearing connective tissues', BioEssays, 30, pp. 457 - 469, http://dx.doi.org/10.1002/bies.20748
    Journal articles | 2008
    2008, 'Recombinant heparan sulfate for use in tissue engineering applications', Journal of Chemical Technology and Biotechnology, 83, pp. 496 - 504, http://dx.doi.org/10.1002/jctb.1835
    Journal articles | 2008
    2008, 'Structural and functional characterisation of poly (vinyl alcohol) and heparin hydrogels', Biomaterials, 29, pp. 4658 - 4664, http://dx.doi.org/10.1016/j.biomaterials.2008.08.011
    Journal articles | 2008
    2008, 'Tissue engineering of cartilages using biomatrices', Journal of Chemical Technology and Biotechnology, 83, pp. 444 - 463, http://dx.doi.org/10.1002/jctb.1857
    Journal articles | 2007
    2007, 'Graphitized carbon LC-MS characterization of the chondroitin sulfate oligosaccharides of aggrecan', Analytical Chemistry, 79, pp. 3597 - 3606, http://dx.doi.org/10.1021/ac0622227
    Journal articles | 2007
    2007, 'Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibilar gland branching morphogenesis', Development (Cambridge), 134, pp. 4177 - 4186, http://dx.doi.org/10.1242/dev.011171
    Journal articles | 2006
    Lord MS; Cousins B; Doherty P; Whitelock J; Simmons A; Williams R; Milthorpe BK, 2006, 'The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response', Biomaterials, 27, pp. 4856 - 4862, http://dx.doi.org/10.1016/j.biomaterials.2006.05.037
    Journal articles | 2006
    2006, 'Perlecan: how does one molecule do so many things?', CMLS - Cellular and Molecular Life Sciences, 63, pp. 2435 - 2445, http://dx.doi.org/10.1007/s00018-006-6162-z
    Journal articles | 2006
    2006, 'Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation', The Journal of Biological Chemistry, 281, pp. 5178 - 5187, http://dx.doi.org/10.1074/jbc.M509500200
    Journal articles | 2006
    2006, 'The role of heparan sulfate and perlecan in bone-regenerative procedures', Journal of Dental Research, 85, pp. 122 - 132, http://dx.doi.org/10.1177/154405910608500203
    Journal articles | 2006
    2006, 'The structure, location and function of perlecan, a prominent pericellular proteoglycan of foetal, postnatal and mature hyaline cartilages', The Journal of Biological Chemistry, 281, pp. 36905 - 36914, http://dx.doi.org/10.1074/jbc.M608462200
    Journal articles | 2005
    Whitelock J; Iozzo R, 2005, 'Heparan sulfate: a complex polymer charged with biological activity', Chemical Reviews, 105, pp. 2745 - 2764, http://dx.doi.org/10.1002/chin.200542258
    Journal articles | 2005
    Whitelock JM; Iozzo RV, 2005, 'Heparan sulfate: A complex polymer charged with biological activity', Chemical Reviews, 105, pp. 2745 - 2764, http://dx.doi.org/10.1021/cr010213m
    Journal articles | 2005
    2005, 'Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study', Histochemistry and Cell Biology, 124, pp. 225 - 235, http://dx.doi.org/10.1007/s00418-005-0005-0
    Journal articles | 2005
    2005, 'Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint', Histochemistry and Cell Biology, 123, pp. 561 - 571, http://dx.doi.org/10.1007/s00418-005-0789-y
    Journal articles | 2005
    2005, 'Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan', FEBS Letters, 579, pp. 5019 - 5023, http://dx.doi.org/10.1016/j.febslet.2005.07.090
    Journal articles | 2005
    2005, 'Use of graphitised carbon negative ion LC-MS to analyse enzymatically digested glycosaminoglycans', Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 824, pp. 139 - 147, http://dx.doi.org/10.1016/j.jchromb.2005.07.014
    Journal articles | 2004
    Chau NC; Whitelock J; Poole-Warren L, 2004, 'Proteoglycans and the bioengineering of vascular grafts: Perlecan, a non-thrombogenic treatment', Transactions - 7th World Biomaterials Congress, pp. 400
    Journal articles | 2004
    2004, 'Perlecan immunolocalizes to perichondrial vessels and canals in humanfetal cartilaginous primordia in early vascular and matrix remodelingevents associated with diarthrodial joint development', Journal of Histochemistry and Cytochemistry, 52, pp. 1405 - 1413, http://dx.doi.org/10.1369/jhc.4A6261.2004
    Journal articles | 2004
    2004, 'Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN', Circulation Research, 94, pp. 175 - 183, http://dx.doi.org/10.1161/01.RES.0000109791.69181.B6
    Journal articles | 2003
    Melrose J; Smith S; Ghosh P; Whitelock J, 2003, 'Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine', Journal of Histochemistry and Cytochemistry, 51, pp. 1331 - 1341, http://dx.doi.org/10.1177/002215540305101010
    Journal articles | 2003
    Walker HA; Whitelock JM; Garl PJ; Nemenoff RA; Stenmark KR; Weiser-Evans MC M, 2003, 'Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling', Molecular Biology of the Cell, 14, pp. 1941 - 1952, http://dx.doi.org/10.1091/mbc.E02-08-0508
    Journal articles | 2002
    Melrose J; Smith S; Knox S; Whitelock J, 2002, 'Perlecan, the multidomain HS-proteoglycan of basement membranes, is a prominent pericellular component of ovine hypertrophic vertebral growth plate and cartilaginous endplate chondrocytes', Histochemistry and Cell Biology, 118, pp. 269 - 280, http://dx.doi.org/10.1007/s00418-002-0449-4
    Journal articles | 2002
    Underwood PA; Whitelock JM; Bean PA; Steele JG, 2002, 'Effects of base material, plasma proteins and FGF2 on endothelial cell adhesion and growth', Journal of Biomaterials Science, Polymer Edition, 13, pp. 845 - 862, http://dx.doi.org/10.1163/156856202320401924
    Journal articles | 2002
    Whitelock JM; Iozzo RV, 2002, 'Isolation and purification of proteoglycans', Methods in Cell Biology, 2002, pp. 53 - 67, http://dx.doi.org/10.1016/S0091-679X(02)69007-7
    Journal articles | 2002
    2002, 'Not all perlecans are created equal: Interactions with fibroclast growth factor (FGF) 2 and FGF receptors', The Journal of Biological Chemistry, 277 (17), pp. 14657 - 14665, http://dx.doi.org/10.1074/jbc.M111826200
    Journal articles | 2001
    Knox S; Melrose J; Whitelock J, 2001, 'Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins', Proteomics, 1, pp. 1534 - 1541, http://dx.doi.org/10.1002/1615-9861(200111)1:12<1534::AID-PROT1534>3.0.CO;2-A
    Journal articles | 2001
    Underwood PA; Bean PA; Mitchell SM; Whitelock JM, 2001, 'Specific affinity depletion of cell adhesion molecules and growth factors from serum', Journal of Immunological Methods, 247, pp. 217 - 224, http://dx.doi.org/10.1016/S0022-1759(00)00327-6
    Journal articles | 2001
    Whitelock J, 2001, 'Purification of perlecan from endothelial cells.', Methods in molecular biology (Clifton, N.J.), 171, pp. 27 - 34
    Journal articles | 2000
    Mongiat M; Taylor K; Otto J; Aho S; Uitto J; Whitelock JM; Iozzo RV, 2000, 'The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7', Journal of Biological Chemistry, 275, pp. 7095 - 7100, http://dx.doi.org/10.1074/jbc.275.10.7095
    Journal articles | 2000
    Whitelock J; Bean P; Knox S; Graham L; Mitchell S; Underwood A, 2000, 'The purification and characterization of recombinant domain I of perlecan expressed in HEK-293 cells', Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, pp. 112
    Journal articles | 1999
    Graham LD; Whitelock JM; Underwood PA, 1999, 'Expression of human perlecan domain I as a recombinant heparan sulfate proteoglycan with 20-kDa glycosaminoglycan chains', Biochemical and Biophysical Research Communications, 256, pp. 542 - 548, http://dx.doi.org/10.1006/bbrc.1999.0377
    Journal articles | 1999
    Whitelock J; Mitchell S; Underwood PA, 1999, 'Erratum: The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth (Cell Biology International (1997) 21 (181-189))', Cell Biology International, 23, pp. 451, http://dx.doi.org/10.1006/cbir.1999.0353
    Journal articles | 1999
    Whitelock JM; Graham LD; Melrose J; Murdoch AD; Iozzo RV; Anne Underwood P, 1999, 'Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells', Matrix Biology, 18, pp. 163 - 178, http://dx.doi.org/10.1016/S0945-053X(99)00014-1
    Journal articles | 1998
    Melrose J; Whitelock J; Xu Q; Ghosh P, 1998, 'Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells', Journal of Vascular Surgery, 28, pp. 676 - 686, http://dx.doi.org/10.1016/S0741-5214(98)70094-1
    Journal articles | 1998
    Sharma B; Handler M; Eichstetter I; Whitelock JM; Nugent MA; Iozzo RV, 1998, 'Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo', Journal of Clinical Investigation, 102, pp. 1599 - 1608, http://dx.doi.org/10.1172/JCI3793
    Journal articles | 1998
    Underwood PA; Bean PA; Whitelock JM, 1998, 'Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: Role of type V collagen', Atherosclerosis, 141, pp. 141 - 152, http://dx.doi.org/10.1016/S0021-9150(98)00164-6
    Journal articles | 1998
    Underwood PA; Mitchell SM; Whitelock JM, 1998, 'Heparin fails to inhibit the proliferation of human vascular smooth muscle cells in the presence of human serum', Journal of Vascular Research, 35, pp. 449 - 460, http://dx.doi.org/10.1159/000025616
    Journal articles | 1997
    Graham LD; Hayward IP; Fitzgerald M; Whitelock JM; Bingley JA; Campbell JH; Underwood PA, 1997, 'Inhibition of phenotype modulation, growth, and migration of vascular smooth muscle cells by a guanosine-rich 30-mer phosphorothioate oligodeoxynucleotide', Cell Biology International, 21, pp. 585 - 594, http://dx.doi.org/10.1006/cbir.1997.0189
    Journal articles | 1997
    Whitelock J; Mitchell S; Underwood PA, 1997, 'The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth', Cell Biology International, 21, pp. 181 - 189, http://dx.doi.org/10.1006/cbir.1996.0125
    Journal articles | 1996
    Whitelock JM; Murdoch AD; Iozzo RV; Underwood PA, 1996, 'The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases', Journal of Biological Chemistry, 271, pp. 10079 - 10086, http://dx.doi.org/10.1074/jbc.271.17.10079
    Journal articles | 1993
    Gibbins JR; Paine ML; Whitelock JM; O'Grady RL; Kefford RF, 1993, 'Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression', Journal of the National Cancer Institute, 85, pp. 1425 - 1427, http://dx.doi.org/10.1093/jnci/85.17.1425
    Journal articles | 1993
    Lyons JG; Birkedal-Hansen B; Pierson MC; Whitelock JM; Birkedal-Hansen H, 1993, 'Interleukin-1β and transforming growth factor-α/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes', Journal of Biological Chemistry, 268, pp. 19143 - 19151
    Journal articles | 1993
    WHITELOCK JM; PAINE ML; GIBBINS JR; KEFFORD RF; O'GRADY RL, 1993, 'Multiple levels of post‐transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line', Immunology and Cell Biology, 71, pp. 39 - 47, http://dx.doi.org/10.1111/j.1440-1711.1993.tb03386.x
    Journal articles | 1992
    Nethery A; Giles I; Jenkins K; Jackson C; Brooks P; Burkhardt D; Ghosh P; Whitelock J; O'Grady RL; Welgus HG; Schrieber L, 1992, 'The chondroprotective drugs, arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro', Biochemical Pharmacology, 44, pp. 1549 - 1553, http://dx.doi.org/10.1016/0006-2952(92)90471-T
    Journal articles | 1992
    Whitelock JM; O'Grady RL, 1992, 'The production of collagenase and an inhibitor of collagenase by rat mammary carcinoma cells.', Matrix (Stuttgart, Germany). Supplement, 1, pp. 413 - 414
    Journal articles | 1991
    Whitelock JM; O'Grady RL; Gibbins JR, 1991, 'Interstitial collagenase (matrix metalloproteinase 1) associated with the plasma membrane of both neoplastic and nonneoplastic cells', Invasion and Metastasis, 11, pp. 139 - 148
    Journal articles | 1991
    Whitelock JM; O'Grady RL; Gibbins JR, 1991, 'Interstitial collagenase (matrix metalloproteinase 1) associated with the plasma membrane of both neoplastic and nonneoplastic cells', Invasion and Metastasis, 11, pp. 139 - 148
    Journal articles | 1991
    Whitelock JM; O'Grady RL; Gibbins JR, 1991, 'The identification, purification and characterisation of an inhibitor of collagenase (20K) produced by neoplastic epithelial cells', BBA - General Subjects, 1073, pp. 107 - 113, http://dx.doi.org/10.1016/0304-4165(91)90189-N
    Journal articles | 1989
    Whitelock JM; O'Grady RL; Lyons JG, 1989, 'Immunolocalization of collagenase in neoplastic epithelial cells', Immunology and Cell Biology, 67, pp. 349 - 357, http://dx.doi.org/10.1038/icb.1989.51
  • Preprints | 2022
    2022, Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma, , http://dx.doi.org/10.20944/preprints202211.0160.v1
    Conference Abstracts | 2021
    2021, 'A CRISPR/Cas9 in vitro human-induced pluripotent stem cell (hiPSC) model to investigate the role of perlecan in cardiovascular fibrotic disease', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, Vol. 102, pp. 126 - 127, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000630872200029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    2018, 'Developing an in vitro human induced pluripotent stem cell (hiPSC) model using CRISPR/Cas9 to investigate the role of perlecan in fibrosis', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, ENGLAND, Manchester, Vol. 99, pp. A20 - A21, presented at Matrix Biology Europe Meeting, ENGLAND, Manchester, 21 July 2018 - 24 July 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459467900041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    2018, 'Investigating the roles of perlecan using antibodies with unique epitopes', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, ENGLAND, Manchester, Vol. 99, pp. A23 - A23, presented at Matrix Biology Europe Meeting, ENGLAND, Manchester, 21 July 2018 - 24 July 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459467900046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Thompson J; Ashworth J; Whitelock J; Merry C, 2017, 'Modelling the brain tumour microenvironment', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, ENGLAND, Univ Oxford, Oxford, Vol. 98, pp. A22 - A22, presented at Spring Meeting of the British-Society-for-Matrix-Biology (BSMB), ENGLAND, Univ Oxford, Oxford, 03 April 2017 - 04 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408620000047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Farrugia BL; Whitelock J; LORD M, 2016, 'The inflammatory response to implanted materials, fibrous capsule characterisation', in Front. Bioeng. Biotechnol., 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016., presented at 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016., http://dx.doi.org/10.3389/conf.FBIOE.2016.01.00994
    Conference Abstracts | 2016
    Farrugia BL; Whitelock J; Lord M, 2016, 'CHITOSAN SULPHATE: ENGINEERING A BIOMIMETIC GROWTH FACTOR DELIVERY SYSTEM', in Wound Repair and Regeneration, Wiley, Melbourne, Australia, Vol. 24, pp. A13 - A30, presented at Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne, Australia, 07 November 2016 - 09 November 2016, http://dx.doi.org/10.1111/wrr.12489
    Conference Abstracts | 2016
    Lord M; Whitelock J; Cheng B; Tang F; Lyons G, 2016, 'Bioengineering of human heparin: A next generation anti-coagulant', in The FASEB Journal, Federation of American Society of Experimental Biology (FASEB), San Diego, Vol. 30, pp. 1070.5 - 1070.5, presented at Experimental Biology 2016 Meeting, San Diego, 02 April 2016 - 06 April 2016
    Conference Abstracts | 2016
    Lord M; chuang C; rnjak-kovacina J; cheng B; lyons G; whitelock J, 2016, 'Bioengineering proteoglycan-based matrices for blood contacting applications', in The FASEB Journal, Federation of American Society of Experimental Biology (FASEB), San Diego, Vol. 6, pp. 622.2 - 622.2, presented at Experimental Biology 2016, San Diego, 02 April 2016 - 06 April 2016
    Conference Abstracts | 2016
    Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Domain V of Perlecan Covalently Immobilized on Silk Biomaterials Modulates Endothelial Cell and Platelet Interactions for Vascular Applications', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, CA, San Diego, Vol. 22, pp. S20 - S21, presented at TERMIS - Americas Conference and Exhibition, CA, San Diego, 11 December 2016 - 14 December 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000390569200074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Tang F; Lau K; Kondyurin A; Lord MS; Whitelock JM; Bilek MM; Rnjak-Kovacina J, 2016, 'Plasma Immersion Ion Implantation Treatment of Silk Biomaterials Enhances Biological Function', in Plasma Immersion Ion Implantation Treatment of Silk Biomaterials Enhances Biological Function, TISSUE ENGINEERING PART A, San Diego, Vol. 22, pp. S129 - S129, presented at TISSUE ENGINEERING PART A, San Diego, 11 December 2016 - 14 December 2016
    Conference Abstracts | 2016
    2016, 'Chitosan sulfate: engineering a biomimetic growth factor delivery system', in Front. Bioeng. Biotechnol., WILEY-BLACKWELL, Vol. 24, pp. A18 - A18, presented at 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016, http://dx.doi.org/10.3389/conf.FBIOE.2016.01.01019
    Conference Papers | 2016
    2016, 'The potent inflammatory oxidant, peroxynitrite, modifies the extracellular matrix of human atherosclerotic lesions', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, HUNGARY, Budapest, pp. S45 - S45, presented at Conference of the Society-for-Free-Radical-Research-Europe (SFRR-E), HUNGARY, Budapest, 08 June 2016 - 11 June 2016, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.093
    Conference Abstracts | 2015
    Gunatillake T; Chui A; Lord M; Whitelock J; Murthi P; Ignatovic V; Monagle P; Brennecke S; Said J, 2015, '[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.', in Pregnancy Hypertens, Netherlands, Vol. 5, pp. 144, Netherlands, http://dx.doi.org/10.1016/j.preghy.2014.10.295
    Conference Abstracts | 2014
    Whitelock J; Jung M; Cheng B; Lord M, 2014, 'Transcriptional regulation and proteolytic processing of perlecan in mast cells lead to the production of forms that contain the alpha2/beta1 integrin binding site: roles in wound healing and tissue regeneration', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, Vol. 28, presented at Experimental Biology Meeting, CA, San Diego, 26 April 2014 - 30 April 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346646701331&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Chuang CY; Degendorfer G; Hammer A; Malle E; Whitelock JM; Davies MJ, 2012, 'Peroxynitrite Modulates Endothelial Cell-Derived Extracellular Matrix in Human Atherosclerotic Lesions', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, CA, San Diego, pp. S134 - S134, presented at 19th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM), CA, San Diego, 14 November 2012 - 18 November 2012, http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.364
    Conference Abstracts | 2012
    Jung M; Lord M; Cheng B; Lyons JG; Alkhouri H; Hughes JM; McCarthy S; Iozzo R; Whitelock J, 2012, 'Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: A role in angiogenesis and wound healing', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, CA, San Diego, Vol. 22, pp. 1627 - 1628, presented at Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology, CA, San Diego, 11 November 2012 - 14 November 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310368700326&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2012
    Lord M; Day A; Youssef P; Zhuo L; Watanabe H; Caterson B; Whitelock J, 2012, 'Chondroitin sulfate-mediated stabilization of hyaluronan-rich matrices', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, CA, San Diego, Vol. 22, pp. 1627 - 1627, presented at Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology, CA, San Diego, 11 November 2012 - 14 November 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310368700324&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2012
    Penm S; Lord MS; O'Grady R; Whitelock J, 2012, 'Expression of matrix components in liver cells: Studies in human hepatocytes (HepG2) and hepatic stellate cells (LX-2)', in Glycobiology, Vol. 22, pp. 1546 - 1547, http://dx.doi.org/10.1093/glycob/cws127
    Conference Abstracts | 2012
    Whitelock JM; Jung MS; Chuang CY; Cheng B; Koo T; Lyons JG; Lord MS, 2012, 'Shorter forms of the proteoglycan, Perlecan; Adding complexity to an already complex molecule', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, Vol. 26, presented at Experimental Biology Meeting, CA, San Diego, 21 April 2012 - 25 April 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310711305959&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2012
    (ed.), 2012, 'The roles of melanoma-associated protein (CSPG4) and perlecan (HSPG2) in cancer, potential targets for drug therapy', in Glycobiology, OXFORD UNIV PRESS INC, San Diego, CA, Vol. 22, pp. 1605 - 1605, presented at Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology, San Diego, CA, 11 - 14 November 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310368700259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Presentations | 2011
    Young C; Cheng J; Whitelock J; Martens P; Poole-Warren L, 2011, 'Islet matrix identification for use in biosynthetic microencapsulation'
    Conference Papers | 2010
    2010, 'Extracellular Matrix Proteoglycans are a Major Target for Peroxynitrite in the Artery Wall', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, FL, Orlando, pp. S113 - S113, presented at 17th Annual Meeting of the Society-for-Free-Radical-Biology-Medicine /15th Biennial Meeting of the Society-for-Free-Radical-Research-International, FL, Orlando, 17 November 2010 - 21 November 2010, http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.302
    Conference Papers | 2009
    Kennett EC; Rees MD; Whitelock JM; Davies MJ, 2009, 'Peroxynitrite Modifies the Structure and Function of the Extracellular Matrix Proteoglycan Perlecan by Reaction with both the Protein Core and the Heparan Sulfate Chains', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, CA, San Francisco, pp. S73 - S74, presented at 16th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine, CA, San Francisco, 18 November 2009 - 22 November 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271988500207&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2009
    Martens P; Nilasaroya A; Reeves A; Kundu ; Kundu S; Whitelock J; Poole-Warren LA, 2009, 'Poly (Vinyl Alcohol) Hydrogels: Improving Biological Performance', presented at European Society for Biomaterials 2009, Lausanne, Switzerland
    Conference Presentations | 2009
    Martens P; Nilasaroya A; Whitelock J; Poole-Warren LA, 2009, 'Biosynthetic Hydrogel Composite Materials: Maintaining Network Structure and Improving Biological Performance', presented at Biomaterials Asia, Hong Kong, -
    Conference Presentations | 2009
    Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2009, 'Poly(Vinyl Aochol)-Heparin Hydrogels: Growth Factor Activation and Degradation', presented at BITE&RM and Australasian Society for Biomaterials and Tissue Engineering 2009, Sydney, Australia
    Conference Papers | 2009
    2009, 'The role of heparan sulfate on chondrocyte perlecan - to proliferate or not?', in International Journal of Experimental Pathology, Blackwell Publishing Ltd, Oxford, England, pp. A102 - A103, presented at Annual General Meeting of the British-Society-for-Matrix-Biology, York Univ, York, ENGLAND, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264345300021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Abstracts | 2008
    Lord M; Ma J; Davies N; Chuang C; Nielsen N; Iozzo R; Whitelock J, 2008, 'Modulation of biosignalling using recombinant heparan sulfate', in 8th World Biomaterials Congress 2008, Vol. 3, pp. 1237
    Conference Posters | 2008
    Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2008, 'Structural and Functional Characterisation of Poly (Vinyl Alcohol) and Heparin Copolymers', Canberra, Australia, presented at 18th Annual Australasian Society for Biomaterials and Tissue Engineering Conference, Canberra, Australia, 22 February 2008 - 22 February 2008
    Conference Presentations | 2008
    2008, 'Structural and Functional Characterization of Poly (Vinyl Alcohol) and Heparin Copolymers', Vol. 2, pp. 872, presented at World Biomaterials Congress, Amsterdam, Netherlands
    Conference Presentations | 2007
    Martens P; Whitelock J; Poole-Warren LA, 2007, 'Characterisation of Redox Polymerised Poly (Vinyl Alcohol) Hydrogels', presented at International Congress on Biohydrogels, Viareggio, Italy
    Conference Presentations | 2007
    Martens P; Whitelock J; Poole-Warren LA, 2007, 'Redox Initiated Hydrogels for Tissue Engineering Applications', presented at Australasian Society for Biomaterials and Tissue Engineering 2007, Mt Eliza, Australia, -
    Conference Presentations | 2007
    Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2007, 'Characterisation of Poly(Vinyl Alcohol) and Heparin Hydrogels Formed from Methacrylated Macromers', presented at Australasian Society for Biomaterials and Tissue Engineering 2007, Mt Eliza, Australia, -
    Conference Presentations | 2007
    Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2007, 'Network Formation of Poly(Vinyl Alcohol)-Heparin Hydrogels', presented at International Congress on Biohydrogels, Viareggio, Italy
    Conference Presentations | 2007
    Poole-Warren LA; Nilasaroya A; Grant M; Whitelock J; Martens P, 2007, 'Biosynthetic Hydrogels as injectable soft-tissue engineering scaffolds', presented at TERMIS-AP, Tokyo, Japan
    Conference Presentations | 2007
    Whitelock J; Davies N; Jung M; Nilasaroya A; Chuang C; Neilsen N; Martens P, 2007, 'Heparan Sulfate as a Biosignalling Molecule for Tissue Engineering Applications', presented at TERMIS-AP, Tokyo, Japan
    Conference Papers | 2007
    2007, 'Oxidative degradation of perlecan, a key matrix proteoglycan, by myclopcroxidase-derived oxidants and its consequences', in Free Radical Research, Taylor & Francis Ltd, Abingdon, England, pp. S49 - S49, presented at SFRR-Europe, Vilamoura, PORTUGAL, 10 October 2007 - 13 October 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252296300182&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Proceedings (Editor of) | 2004
    Chau N; Poole-Warren LA; Whitelock J, (eds.), 2004, '7th World Biomaterials Congress', Sydney, presented at 7th World Biomaterials Congress, Sydney, 17 May 2004 - 21 May 2004
    Conference Proceedings (Editor of) | 2004
    Whitelock J; Karlsson N; Melrose J; Knox SM; Schulz B; Packer N; Last K; Fosang A, (eds.), 2004, 'Matrix Biology Society of Australia and New Zealand', Rottnest Island, WA, presented at Matrix Biology Society of Australia and New Zealand, Rottnest Island, WA
    Conference Proceedings (Editor of) | 2004
    Whitelock J; Karlsson N; Melrose J; Knox SM; Schulz B; Robinson L; Packer N; Last K; Fosang A, (eds.), 2004, 'Gordon Conference on Proteoglycans', New Hampshire, USA, presented at Gordon Conference on Proteoglycans, New Hampshire, USA
    Conference Proceedings (Editor of) | 2003
    Melrose J; Smith SA; Ghosh P; Whitelock J, (eds.), 2003, 'Orthopedic Research Society', Orleans, USA, presented at Orthopedic Research Society, Orleans, USA
    Conference Proceedings (Editor of) | 2003
    Whitelock J; Schulz B; Knox SM; Melrose J; Packer N, (eds.), 2003, 'Osteoarthritis Research Society International', Berlin, Germany, presented at Osteoarthritis Research Society International, Berlin, Germany