Emeritus Professor John Whitelock

Back to

Research Interests:
Tissue repair and regeneration involves interactions between the extracellular environment that binds growth signals and guides cell and tissue behavior. The activity of these signals is controlled by glycosylated molecules known as proteoglycans and this is my central area of research interest.

Broad Research Areas:
Biochemistry, Biomedical Engineering, Cell Biology and Gene Regulation, Cardiology and Vascular Disease, Proteomics

Society Memberships & Professional Activities:
International Society for Matrix Biology, American Society for Matrix Biology, Australian and New Zealand Society for Matrix Biology - President, Australian Society for Medical Research

Specific Research Keywords:
Glycomics, Mass Spectrometry, Proteoglycans, Tissue Regeneration, mast cell biology

Mobile

0408162115

Phone

+61-2-9385-3948

E-mail

j.whitelock@unsw.edu.au

Location

Graduate School of Biomedical Engineering Level 5, Samuels Bldg University of New South Wales Sydney, Australia, 2052

Book Chapters | 2015

Vassie JA; Whitelock JM; Lord MS, 2015, 'Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions', in , http://dx.doi.org/10.1007/978-1-4939-1714-3_44

Book Chapters | 2009

Estrella RP; Whitelock J; Roubin RH; Packer N; Karlsson N, 2009, 'Small-Scale Enzymatic Digestion of Glycoproteins and Proteoglycans for Analysis of Oligosaccharides by LC-MS and FACE Gel Electrophoresis', in Parker NH; Karlsson NG (ed.), Glycomics: Methods and Protocols (Methods in Molecular Biology), Volume 534, Humana Press, Inc, United States, pp. 171 - 192, http://dx.doi.org/10.1007/978-1-59745-022-5_13

Book Chapters | 2006

Melrose J; Whitelock J, 2006, 'Extracellular Matrix', in Metin Akay (ed.), Wiley Encyclopedia of Biomedical Engineering, John Wiley & Sons, USA, pp. 1556 - 1577

Book Chapters | 2006

Whitelock J; Melrose J, 2006, 'Adhesion of cells to biomaterials', in Metin Akay (ed.), Wiley Encyclopedia of Biomedical Engineering, John Wiley & Sons, USA, pp. 16 - 23

Book Chapters | 2001

Whitelock J, 2001, 'Purification of Perlecan from Endothelial Cells', in Proteoglycan Protocols, Springer Nature, pp. 27 - 34, http://dx.doi.org/10.1385/1-59259-209-0:027
Journal articles | 2024

Johnson BB; Cosson MV; Tsansizi LI; Holmes TL; Gilmore T; Hampton K; Song OR; Vo NTN; Nasir A; Chabronova A; Denning C; Peffers MJ; Merry CLR; Whitelock J; Troeberg L; Rushworth SA; Bernardo AS; Smith JGW, 2024, 'Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes', Cell Reports, 43, http://dx.doi.org/10.1016/j.celrep.2023.113668

Journal articles | 2023

Guo Z; Zhuang C; Song Y; Yong J; Li Y; Guo Z; Kong B; Whitelock JM; Wang J; Liang K, 2023, 'Biocatalytic Buoyancy-Driven Nanobots for Autonomous Cell Recognition and Enrichment', Nano-Micro Letters, 15, http://dx.doi.org/10.1007/s40820-023-01207-1

Journal articles | 2023

Kim HN; Elgundi Z; Lin X; Fu L; Tang F; Moh ESX; Jung MS; Chandrasekar K; Bartlett-Tomasetig F; Foster C; Packer NH; Whitelock JM; Rnjak-Kovacina J; Lord MS, 2023, 'Engineered short forms of perlecan enhance angiogenesis by potentiating growth factor signalling', Journal of Controlled Release, 362, pp. 184 - 196, http://dx.doi.org/10.1016/j.jconrel.2023.08.052

Journal articles | 2023

Lau K; Fu L; Zhang A; Akhavan B; Whitelock J; Bilek MM; Lord MS; Rnjak-Kovacina J, 2023, 'Recombinant perlecan domain V covalently immobilized on silk biomaterials via plasma immersion ion implantation supports the formation of functional endothelium', Journal of Biomedical Materials Research - Part A, 111, pp. 825 - 839, http://dx.doi.org/10.1002/jbm.a.37525

Journal articles | 2023

Yong J; Hakobyan K; Xu J; Mellick AS; Whitelock J; Liang K, 2023, 'Comparison of protein quantification methods for protein encapsulation with ZIF-8 metal-organic frameworks', Biotechnology Journal, 18, http://dx.doi.org/10.1002/biot.202300015

Journal articles | 2023

Yong J; Mellick AS; Whitelock J; Wang J; Liang K, 2023, 'A Biomolecular Toolbox for Precision Nanomotors', Advanced Materials, 35, pp. e2205746, http://dx.doi.org/10.1002/adma.202205746

Journal articles | 2022

Chen K; Yong J; Zauner R; Wally V; Whitelock J; Sajinovic M; Kopecki Z; Liang K; Scott KF; Mellick AS, 2022, 'Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma', Cancers, 14, pp. 5564, http://dx.doi.org/10.3390/cancers14225564

Journal articles | 2022

Fu L; Li R; Whitelock JM; Lord MS, 2022, 'Tuning the intentional corona of cerium oxide nanoparticles to promote angiogenesis via fibroblast growth factor 2 signalling', Regenerative Biomaterials, 9, http://dx.doi.org/10.1093/rb/rbac081

Journal articles | 2022

Hayes AJ; Whitelock J; Melrose J, 2022, 'Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms23041934

Journal articles | 2022

Karimi F; Lau K; Kim HN; Och Z; Lim KS; Whitelock J; Lord M; Rnjak-Kovacina J, 2022, 'Surface Biofunctionalization of Silk Biomaterials Using Dityrosine Cross-Linking', ACS Applied Materials and Interfaces, 14, pp. 31551 - 31566, http://dx.doi.org/10.1021/acsami.2c03345

Journal articles | 2022

Mizumoto S; Kwok JCF; Whitelock JM; Li F; Perris R, 2022, 'Editorial: Roles of Chondroitin Sulfate and Dermatan Sulfate as Regulators for Cell and Tissue Development', Frontiers in Cell and Developmental Biology, 10, http://dx.doi.org/10.3389/fcell.2022.941178

Journal articles | 2022

Yong JM; Fu L; Tang F; Yu P; Kuchel RP; Whitelock JM; Lord MS, 2022, 'ROS-Mediated Anti-Angiogenic Activity of Cerium Oxide Nanoparticles in Melanoma Cells', ACS Biomaterials Science and Engineering, 8, pp. 512 - 525, http://dx.doi.org/10.1021/acsbiomaterials.1c01268

Journal articles | 2021

Chandrasekar K; Farrugia BL; Johnson L; Marks D; Irving D; Elgundi Z; Lau K; Kim HN; Rnjak-Kovacina J; Bilek MM; Whitelock JM; Lord MS, 2021, 'Effect of Recombinant Human Perlecan Domain V Tethering Method on Protein Orientation and Blood Contacting Activity on Polyvinyl Chloride', Advanced Healthcare Materials, 10, http://dx.doi.org/10.1002/adhm.202100388

Journal articles | 2021

Lau K; Waterhouse A; Akhavan B; Gao L; Kim HN; Tang F; Whitelock JM; Bilek MM; Lord MS; Rnjak-Kovacina J, 2021, 'Biomimetic silk biomaterials: Perlecan-functionalized silk fibroin for use in blood-contacting devices', Acta Biomaterialia, 132, pp. 162 - 175, http://dx.doi.org/10.1016/j.actbio.2021.02.014

Journal articles | 2021

Liu J; Guo Z; Li Y; Liang J; Xue J; Xu J; Whitelock JM; Xie L; Kong B; Liang K, 2021, 'pH-Gated Activation of Gene Transcription and Translation in Biocatalytic Metal–Organic Framework Artificial Cells', Advanced NanoBiomed Research, 1, http://dx.doi.org/10.1002/anbr.202000034

Journal articles | 2021

Ng CY; Whitelock JM; Williams H; Kim HN; Medbury HJ; Lord MS, 2021, 'Macrophages bind LDL using heparan sulfate and the perlecan protein core', Journal of Biological Chemistry, 296, pp. 100520, http://dx.doi.org/10.1016/j.jbc.2021.100520

Journal articles | 2020

Elgundi Z; Papanicolaou M; Major G; Cox TR; Melrose J; Whitelock JM; Farrugia BL, 2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, 9, pp. 1482, http://dx.doi.org/10.3389/fonc.2019.01482

Journal articles | 2020

Lin X; Tang F; Jiang S; Khamis H; Bongers A; Whitelock JM; Lord MS; Rnjak-Kovacina J, 2020, 'A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials', Adv. Sci., 7, pp. 2000900, http://dx.doi.org/10.1002/advs.202000900

Journal articles | 2020

Lord M; Whitelock J; Turnbull JE, 2020, 'Better growth-factor binding aids tissue repair', Nature Biomedical Engineering, 4, pp. 368 - 369, http://dx.doi.org/10.1038/s41551-020-0548-3

Journal articles | 2020

Lord MS; Melrose J; Day AJ; Whitelock JM, 2020, 'The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology', Journal of Histochemistry and Cytochemistry, 68, pp. 907 - 927, http://dx.doi.org/10.1369/0022155420940067

Journal articles | 2020

Tang F; Manz XD; Bongers A; Odell RA; Joukhdar H; Whitelock JM; Lord MS; Rnjak-Kovacina J, 2020, 'Microchannels are an architectural cue that promotes integration and vascularization of silk biomaterials in vivo', ACS Biomaterials Science and Engineering, 6, pp. 1476 - 1486, http://dx.doi.org/10.1021/acsbiomaterials.9b01624

Journal articles | 2019

Farrugia BL; Mizumoto S; Lord MS; O’Grady RL; Kuchel RP; Yamada S; Whitelock JM, 2019, 'Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms', Journal of Biological Chemistry, 294, pp. 11458 - 11472, http://dx.doi.org/10.1074/jbc.RA119.008647

Journal articles | 2019

Gunatillake T; Chui A; Fitzpatrick E; Ignjatovic V; Monagle P; Whitelock J; Zanten D; Eijsink J; Borg A; Stevenson J; Brennecke SP; Erwich JJHM; Said JM; Murthi P, 2019, 'Decreased placental glypican expression is associated with human fetal growth restriction', Placenta, 76, pp. 6 - 9, http://dx.doi.org/10.1016/j.placenta.2018.12.007

Journal articles | 2018

Farrugia B; Mi Y; Kim HN; Whitelock J; Baker S; Wiesmann W; Li Z; Maitz P; Lord M, 2018, 'Chitosan‐Based Heparan Sulfate Mimetics Promote Epidermal Formation in a Human Organotypic Skin Model', Advanced Functional Materials, 28, http://dx.doi.org/10.1002/adfm.201802818

Journal articles | 2018

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2018, 'The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies', Journal of Histochemistry and Cytochemistry, 66, pp. 321 - 336, http://dx.doi.org/10.1369/0022155417740881

Journal articles | 2018

Farrugia BL; Lord MS; Whitelock JM; Melrose J, 2018, 'Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair', Biomaterials Science, 6, pp. 947 - 957, http://dx.doi.org/10.1039/c7bm01158j

Journal articles | 2018

Hayes A; Sugahara K; Farrugia B; Whitelock JM; Caterson B; Melrose J, 2018, 'Biodiversity of CS–proteoglycan sulphation motifs: Chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis', Biochemical Journal, 475, pp. 587 - 620, http://dx.doi.org/10.1042/BCJ20170820

Journal articles | 2018

Lord M; Rnjak-Kovacina J; Tang F; Whitelock J, 2018, 'Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives', Advanced Healthcare Materials, 7, pp. 1701042 - 1701042, http://dx.doi.org/10.1002/adhm.201701042

Journal articles | 2018

Lord MS; Tang F; Rnjak-Kovacina J; Smith JGW; Melrose J; Whitelock JM, 2018, 'The multifaceted roles of perlecan in fibrosis', Matrix Biology, 68-69, pp. 150 - 166, http://dx.doi.org/10.1016/j.matbio.2018.02.013

Journal articles | 2018

Tang F; Lord M; Stallcup W; Whitelock J, 2018, 'Cell surface chondroitin sulfate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulfate proteoglycan, perlecan, and is involved in cell adhesion', The Journal of Biochemistry

Journal articles | 2018

Vassie JA; Whitelock JM; Lord MS, 2018, 'Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells', Molecular Pharmaceutics, 15, pp. 994 - 1004, http://dx.doi.org/10.1021/acs.molpharmaceut.7b00920

Journal articles | 2017

Chui A; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Van Zanten DE; Eijsink J; Wang Y; Deane J; Borg AJ; Stevenson J; Erwich JJ; Said JM; Murthi P, 2017, 'Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, 37, pp. 1168 - 1179, http://dx.doi.org/10.1161/ATVBAHA.117.309422

Journal articles | 2017

Chui AKL; Gunatillake TN; Ignjatovic V; Monagle PT; Murthi P; Brennecke SP; Whitelock JM; Said JM, 2017, 'Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins', Blood Advances, 1, pp. 1243 - 1253, http://dx.doi.org/10.1182/bloodadvances.2017004333

Journal articles | 2017

Kim HN; Whitelock JM; Lord MS, 2017, 'Structure-activity relationships of bioengineered heparin/heparan sulfates produced in different bioreactors', Molecules, 22, pp. 806, http://dx.doi.org/10.3390/molecules22050806

Journal articles | 2017

Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940

Journal articles | 2017

Lord MS; Cheng B; Farrugia BL; McCarthy S; Whitelock JM, 2017, 'Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation', Journal of Biological Chemistry, 292, pp. 4054 - 4063, http://dx.doi.org/10.1074/jbc.M116.760660

Journal articles | 2017

Lord MS; Ellis AL; Farrugia BL; Whitelock JM; Grenett H; Li C; O'Grady RL; DeCarlo AA, 2017, 'Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing', Journal of Controlled Release, 250, pp. 48 - 61, http://dx.doi.org/10.1016/j.jconrel.2017.02.009

Journal articles | 2017

Lord MS; Jung MS; Whitelock JM, 2017, 'Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications', Bioengineered, 8, pp. 661 - 664, http://dx.doi.org/10.1080/21655979.2017.1301328

Journal articles | 2017

Rnjak-Kovacina J; Tang F; Lin X; Whitelock JM; Lord MS, 2017, 'Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan', Biotechnology Journal, 12, http://dx.doi.org/10.1002/biot.201700196

Journal articles | 2017

Vassie JA; Whitelock JM; Lord MS, 2017, 'Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells', Acta Biomaterialia, 50, pp. 127 - 141, http://dx.doi.org/10.1016/j.actbio.2016.12.010

Journal articles | 2016

Chuang CY-N; Degendorfer G; Kawasaki H; Hammer A; Yamakura F; Whitelock JM; Malle E; Davies MJ, 2016, 'Peroxynitrite Modifies Components of the Extracellular Matrix of Human Atherosclerotic Lesions', Free Radical Biology and Medicine, 100, pp. S139 - S139, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.364

Journal articles | 2016

Dos Santos M; Michopoulou A; André-Frei V; Boulesteix S; Guicher C; Dayan G; Whitelock J; Damour O; Rousselle P, 2016, 'Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin', Aging, 8, pp. 751 - 768, http://dx.doi.org/10.18632/AGING.100928

Journal articles | 2016

Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks D; Irving D; Lord M, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, 11, pp. 029701 - 029701, http://dx.doi.org/10.1116/1.4952450

Journal articles | 2016

Farrugia BL; Whitelock JM; O'Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 64, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649

Journal articles | 2016

Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, 32, pp. 40 - 57, http://dx.doi.org/10.22203/eCM.v032a03

Journal articles | 2016

Lord M; Chuang C; Rnjak‐Kovacina J; Cheng B; Lyons G; Whitelock J, 2016, 'Bioengineering Proteoglycan‐based Matrices For Blood Contacting Applications', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.622.2

Journal articles | 2016

Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity', Metabolic Engineering, 38, pp. 105 - 114, http://dx.doi.org/10.1016/j.ymben.2016.07.006

Journal articles | 2016

Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research - Part A, 104, pp. 1736 - 1746, http://dx.doi.org/10.1002/jbm.a.35704

Journal articles | 2016

Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008

Journal articles | 2016

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications', Colloids and Surfaces B: Biointerfaces, 148, pp. 130 - 138, http://dx.doi.org/10.1016/j.colsurfb.2016.08.039

Journal articles | 2016

Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis and Rheumatology, 68, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529

Journal articles | 2015

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2015, 'The Potent Inflammatory Oxidant, Peroxynitrite, Modifies the Extracellular Matrix of Human Atherosclerotic Lesions', Free Radical Biology and Medicine, 87, pp. S145 - S146, http://dx.doi.org/10.1016/j.freeradbiomed.2015.10.374

Journal articles | 2015

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, 20, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254

Journal articles | 2015

Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, 15, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158

Journal articles | 2015

Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, 20, pp. 121 - 131, http://dx.doi.org/10.1007/s10911-015-9346-z

Journal articles | 2014

Baljinnyam E; Umemura M; Chuang C; De Lorenzo MS; Iwatsubo M; Chen S; Goydos JS; Ishikawa Y; Whitelock JM; Iwatsubo K, 2014, 'Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling', Pigment Cell and Melanoma Research, 27, pp. 611 - 620, http://dx.doi.org/10.1111/pcmr.12250

Journal articles | 2014

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2014, 'Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells', Biochemical Journal, 459, pp. 313 - 322, http://dx.doi.org/10.1042/BJ20131471

Journal articles | 2014

Chui A; Murthi P; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Said JM, 2014, 'Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?', Placenta, 35, pp. 596 - 605, http://dx.doi.org/10.1016/j.placenta.2014.05.009

Journal articles | 2014

Lord MS; Chuang CY; Melrose J; Davies MJ; Iozzo RV; Whitelock JM, 2014, 'The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling', Matrix Biology, 35, pp. 112 - 122, http://dx.doi.org/10.1016/j.matbio.2014.01.016

Journal articles | 2014

Lord MS; Jung MS; Cheng B; Whitelock JM, 2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, 35, pp. 123 - 131, http://dx.doi.org/10.1016/j.matbio.2013.12.005

Journal articles | 2014

Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, 20, pp. 6517 - 6526, http://dx.doi.org/10.1039/c4tb00531g

Journal articles | 2014

Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases, 9, pp. 041002, http://dx.doi.org/10.1116/1.4900993

Journal articles | 2014

2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, 5, pp. 222 - 226, http://dx.doi.org/10.4161/bioe.29388

Journal articles | 2014

2014, 'The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan', , http://dx.doi.org/10.1016/j.biomaterials.2013.10.068

Journal articles | 2013

Chuang CY; Degendorfer G; Hammer A; Malle E; Kawasaki H; Yamakura F; Whitelock JM; Davies MJ, 2013, 'Peroxynitrite-mediated damage in the artery wall and its consequences', FREE RADICAL BIOLOGY AND MEDICINE, 65, pp. S6 - S6, http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.117

Journal articles | 2013

Chui A; Gunatillake T; Murthi P; Ignjatovic V; Monagle P; Whitelock J; Brennecke S; Said J, 2013, 'Unfractionated heparin reverses the increased thrombin generation associated with decorin deficiency in fetal growth restriction', Placenta, 34, pp. A25 - A26, http://dx.doi.org/10.1016/j.placenta.2013.06.078

Journal articles | 2013

Gunatillake T; Chui A; Murthi P; Ignjatovic V; Monagle P; Whitelock J; Brennecke S; Said J, 2013, 'The functional effect of Syndecan 1 deficiency in BeWo cells and its implications in fetal growth restriction', Placenta, 34, pp. A67 - A67, http://dx.doi.org/10.1016/j.placenta.2013.06.201

Journal articles | 2012

Cheng JY; Whitelock J; Poole-Warren LA, 2012, 'Syndecan-4 is associated with betá-cells in the pancreas and the MIN6 beta-cell line', Histochemistry and Cell Biology, 138, pp. 933 - 944, http://dx.doi.org/10.1007/s00418-012-1004-6

Journal articles | 2012

Jin C; Ekwall AKH; Bylund JE; Bjorkman L; Estrella RP; Whitelock J; Eisler T; Bokarewa MI; Karlsson NG, 2012, 'Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity', The Journal of Biological Chemistry, 287, pp. 35922 - 35933, http://dx.doi.org/10.1074/jbc.M112.363119

Journal articles | 2012

Lord MS; Estrella RP; Chuang CY; Youssef P; Karlsson NG; Flannery CR; Whitelock J, 2012, 'Not all lubricin isoforms are substituted with a glycosaminoglycan chain', Connective Tissue Research, 53, pp. 132 - 141, http://dx.doi.org/10.3109/03008207.2011.614364

Journal articles | 2011

Cheng JY; Raghunath M; Whitelock J; Poole-Warren LA, 2011, 'Matrix components and scaffolds for sustained islet function', Tissue Engineering Part B: Reviews, 17, pp. 235 - 247, http://dx.doi.org/10.1089/ten.teb.2011.0004

Journal articles | 2011

Goyal A; Pal N; Concannon M; Paul M; Doran M; Poluzzi C; Sekiguchi K; Whitelock J; Neill T; Iozzo R, 2011, 'Endorepellin, the angiostatic module of perlecan, interacts with both the á2â1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): A dual receptor antagonism', The Journal of Biological Chemistry, 286, pp. 25947 - 25962, http://dx.doi.org/10.1074/jbc.M111.243626

Journal articles | 2011

Kennett EC; Chuang CY; Degendorfer G; Whitelock J; Davies MJ, 2011, 'Mechanisms and consequences of oxidative damage to extracellular matrix', Biochemical Society Transactions, 39, pp. 1279 - 1287, http://dx.doi.org/10.1042/BST0391279

Journal articles | 2011

Whitelock J; Melrose J, 2011, 'Heparan sulfate proteoglycans in healthy and diseased systems', Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 3, pp. 739 - 751, http://dx.doi.org/10.1002/wsbm.149

Journal articles | 2010

Ellis AL; Ellis AL; Yang G; Jones K; Chuang CY; Whitelock J; DeCarlo AA, 2010, 'Similarity of Recombinant Human Perlecan', BMC Biotechnology, pp. 1 - 12

Journal articles | 2010

Ellis AL; Pan W; Yang G; Jones K; Chuang C; Whitelock JM; DeCarlo AA, 2010, 'Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1', BMC Biotechnology, 10, http://dx.doi.org/10.1186/1472-6750-10-66

Journal articles | 2010

Estrella RP; Whitelock J; Packer NH; Karlsson NG, 2010, 'The glycosylation of human synovial lubricin:', Biochemical Journal, 429, pp. 359 - 367

Journal articles | 2010

Estrella RP; Whitelock JM; Packer NH; Karlsson NG, 2010, 'The glycosylation of human synovial lubricin: Implications for its role in inflammation', Biochemical Journal, 429, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20100360

Journal articles | 2010

Kennett EC; Rees MD; Malle E; Hammer A; Whitelock JM; Davies MJ, 2010, 'Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains', Free Radical Biology and Medicine, 49, pp. 282 - 293, http://dx.doi.org/10.1016/j.freeradbiomed.2010.04.018

Journal articles | 2010

Kennett EC; Rees MD; Mallee E; Hammer A; Whitelock J; Davies MJ, 2010, 'Peroxynitrite modifies the structure and function of the extracellular matrix', Free Radical Biology and Medicine, 49, pp. 282 - 293

Journal articles | 2010

Parsi MK; Adams JRJ; Whitelock J; Gibson MA, 2010, 'LTBP-2 has multiple heparin/heparan sulfate binding sites', Matrix Biology, 29, pp. 393 - 401

Journal articles | 2009

Dawson PA; Choyce A; Chuang CY; Whitelock J; Markovich D; Leggatt GR, 2009, 'Enhanced tumor growth in the NaS1 sulfate transporter null mouse', Cancer Science, 101, pp. 369 - 373, http://dx.doi.org/10.1111/j.1349-7006.2009.01399.x

Journal articles | 2009

Lord MS; Yu W; Cheng B; Simmons A; Poole-Warren LA; Whitelock J, 2009, 'The modulation of platelet and endothelial cell adhesion to vascular graft materials by perlecan', Biomaterials, 30, pp. 4898 - 4906, http://dx.doi.org/10.1016/j.biomaterials.2009.05.063

Journal articles | 2009

Rees M; Bottle S; Fairfull-Smith K; Malle E; Whitelock J; Davies MJ, 2009, 'Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides', Biochemical Journal, 421, pp. 79 - 86, http://dx.doi.org/10.1042/bj20090309

Journal articles | 2009

Rees MD; Whitelock J; Malle E; Chuang CY; Iozzo R; Nilasaroya A; Davies MJ, 2009, 'Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan', Matrix Biology, pp. 1 - 11

Journal articles | 2009

Smith S; Whitelock J; Iozzo R; Little C; Melrose J, 2009, 'Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development', Histochemistry and Cell Biology, 132, pp. 491 - 503, http://dx.doi.org/10.1007/s00418-009-0623-z

Journal articles | 2009

Wilson R; Whitelock J; Bateman J, 2009, 'Proteomics makes progress in cartilage and arthritis research', Matrix Biology, 28, pp. 121 - 128, http://dx.doi.org/10.1016/j.matbio.2009.01.004

Journal articles | 2009

Zoeller J; Whitelock J; Iozzo R, 2009, 'Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis', Matrix Biology, 28, pp. 284 - 291, http://dx.doi.org/10.1016/j.matbio.2009.04.010

Journal articles | 2008

Davies NP; Roubin R; Whitelock J, 2008, 'Characterization and purification of glycosaminoglycans from crude biological samples', Journal of Agricultural and Food Chemistry, 56, pp. 343 - 348, http://dx.doi.org/10.1021/jf072624v

Journal articles | 2008

Martens P; Grant M; Nilasaroya A; Whitelock J; Poole-Warren LA, 2008, 'Characterisation of redox initiators for producing poly (vinyl alcohol)hydrogels', Macromolecular Symposia, 266, pp. 59 - 62, http://dx.doi.org/10.1002/masy.200850611

Journal articles | 2008

Melrose J; Chuang CY; Whitelock J, 2008, 'Tissue engineering of cartilages using biomatrices', Journal of Chemical Technology and Biotechnology, 83, pp. 444 - 463, http://dx.doi.org/10.1002/jctb.1857

Journal articles | 2008

Melrose J; Hayes AJ; Whitelock J; Little C, 2008, 'Perlecan, the `jack of all trades` proteoglycan of cartilaginous weight-bearing connective tissues', BioEssays, 30, pp. 457 - 469, http://dx.doi.org/10.1002/bies.20748

Journal articles | 2008

Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2008, 'Structural and functional characterisation of poly (vinyl alcohol) and heparin hydrogels', Biomaterials, 29, pp. 4658 - 4664, http://dx.doi.org/10.1016/j.biomaterials.2008.08.011

Journal articles | 2008

Rees M; Kennett E; Whitelock J; Davies MJ, 2008, 'Oxidative damage to extracellular matrix and its role in human pathologies', Free Radical Biology and Medicine, 44, pp. 1973 - 2001, http://dx.doi.org/10.1016/j.freeradbiomed.2008.03.016

Journal articles | 2008

Whitelock J; Ma J; Davies NP; Nielsen N; Chuang CY; Rees MR; Iozzo R; Knox SM; Lord MS, 2008, 'Recombinant heparan sulfate for use in tissue engineering applications', Journal of Chemical Technology and Biotechnology, 83, pp. 496 - 504, http://dx.doi.org/10.1002/jctb.1835

Journal articles | 2008

Whitelock J; Melrose J; Iozzo R, 2008, 'Diverse cell signalling events modulated by perlecan', Biochemistry, 47, pp. 11174 - 11183

Journal articles | 2008

Zoeller J; McQuillan A; Whitelock J; Ho SY; Iozzo R, 2008, 'A central function for perlecan in skeletal muscle and cardiovascular development', Journal of Cell Biology, 181, pp. 381 - 394

Journal articles | 2007

Estrella RP; Whitelock J; Packer N; Karlsson N, 2007, 'Graphitized carbon LC-MS characterization of the chondroitin sulfate oligosaccharides of aggrecan', Analytical Chemistry, 79, pp. 3597 - 3606, http://dx.doi.org/10.1021/ac0622227

Journal articles | 2007

Patel VN; Knox SM; Likar KM; Lathrop CA; Hossain R; Eftekhari S; Whitelock J; Elkin M; vlodavsky I; Hoffman MP, 2007, 'Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibilar gland branching morphogenesis', Development (Cambridge), 134, pp. 4177 - 4186, http://dx.doi.org/10.1242/dev.011171

Journal articles | 2006

DeCarlo A; Whitelock J, 2006, 'The role of heparan sulfate and perlecan in bone-regenerative procedures', Journal of Dental Research, 85, pp. 122 - 132, http://dx.doi.org/10.1177/154405910608500203

Journal articles | 2006

Knox SM; Whitelock J, 2006, 'Perlecan: how does one molecule do so many things?', CMLS - Cellular and Molecular Life Sciences, 63, pp. 2435 - 2445, http://dx.doi.org/10.1007/s00018-006-6162-z

Journal articles | 2006

Lord MS; Cousins B; Doherty P; Whitelock J; Simmons A; Williams R; Milthorpe BK, 2006, 'The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response', Biomaterials, 27, pp. 4856 - 4862, http://dx.doi.org/10.1016/j.biomaterials.2006.05.037

Journal articles | 2006

Melrose J; Roughley P; Knox SM; Smith S; Lord MS; Whitelock J, 2006, 'The structure, location and function of perlecan, a prominent pericellular proteoglycan of foetal, postnatal and mature hyaline cartilages', The Journal of Biological Chemistry, 281, pp. 36905 - 36914, http://dx.doi.org/10.1074/jbc.M608462200

Journal articles | 2006

Sher I; Zisman-Rozen S; Eliahu L; Whitelock J; Maas-Szabowski N; Yamada Y; Breitkreutz D; Fusenig N; Arikawa-Hirasawa E; Lozzo R; Bergman R; Ron D, 2006, 'Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation', The Journal of Biological Chemistry, 281, pp. 5178 - 5187, http://dx.doi.org/10.1074/jbc.M509500200

Journal articles | 2005

Karlsson N; Schulz B; Packer N; Whitelock J, 2005, 'Use of graphitised carbon negative ion LC-MS to analyse enzymatically digested glycosaminoglycans', Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 824, pp. 139 - 147, http://dx.doi.org/10.1016/j.jchromb.2005.07.014

Journal articles | 2005

Knox SM; Fosang A; Last K; Melrose J; Whitelock J, 2005, 'Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan', FEBS Letters, 579, pp. 5019 - 5023, http://dx.doi.org/10.1016/j.febslet.2005.07.090

Journal articles | 2005

Melrose J; Smith S; Cake M; Read R; Whitelock J, 2005, 'Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study', Histochemistry and Cell Biology, 124, pp. 225 - 235, http://dx.doi.org/10.1007/s00418-005-0005-0

Journal articles | 2005

Melrose J; Smith S; Cake M; Read R; Whitelock J, 2005, 'Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint', Histochemistry and Cell Biology, 123, pp. 561 - 571, http://dx.doi.org/10.1007/s00418-005-0789-y

Journal articles | 2005

Whitelock J; Iozzo R, 2005, 'Heparan sulfate: a complex polymer charged with biological activity', Chemical Reviews, 105, pp. 2745 - 2764, http://dx.doi.org/10.1002/chin.200542258

Journal articles | 2005

Whitelock JM; Iozzo RV, 2005, 'Heparan sulfate: A complex polymer charged with biological activity', Chemical Reviews, 105, pp. 2745 - 2764, http://dx.doi.org/10.1021/cr010213m

Journal articles | 2004

Chau NC; Whitelock J; Poole-Warren L, 2004, 'Proteoglycans and the bioengineering of vascular grafts: Perlecan, a non-thrombogenic treatment', Transactions - 7th World Biomaterials Congress, pp. 400

Journal articles | 2004

Garl P; Wenzlau J; Walker H; Whitelock J; Costell M; Weiser-Evans M, 2004, 'Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN', Circulation Research, 94, pp. 175 - 183, http://dx.doi.org/10.1161/01.RES.0000109791.69181.B6

Journal articles | 2004

Melrose J; Smith ST; Whitelock J, 2004, 'Perlecan immunolocalizes to perichondrial vessels and canals in humanfetal cartilaginous primordia in early vascular and matrix remodelingevents associated with diarthrodial joint development', Journal of Histochemistry and Cytochemistry, 52, pp. 1405 - 1413, http://dx.doi.org/10.1369/jhc.4A6261.2004

Journal articles | 2003

Melrose J; Smith S; Ghosh P; Whitelock J, 2003, 'Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine', Journal of Histochemistry and Cytochemistry, 51, pp. 1331 - 1341, http://dx.doi.org/10.1177/002215540305101010

Journal articles | 2003

Walker HA; Whitelock JM; Garl PJ; Nemenoff RA; Stenmark KR; Weiser-Evans MCM, 2003, 'Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling', Molecular Biology of the Cell, 14, pp. 1941 - 1952, http://dx.doi.org/10.1091/mbc.E02-08-0508

Journal articles | 2002

Knox SM; Merry C; Stringer S; Melrose J; Whitelock J, 2002, 'Not all perlecans are created equal: Interactions with fibroclast growth factor (FGF) 2 and FGF receptors', The Journal of Biological Chemistry, 277 (17), pp. 14657 - 14665

Journal articles | 2002

Melrose J; Smith S; Knox S; Whitelock J, 2002, 'Perlecan, the multidomain HS-proteoglycan of basement membranes, is a prominent pericellular component of ovine hypertrophic vertebral growth plate and cartilaginous endplate chondrocytes', Histochemistry and Cell Biology, 118, pp. 269 - 280, http://dx.doi.org/10.1007/s00418-002-0449-4

Journal articles | 2002

Underwood PA; Whitelock JM; Bean PA; Steele JG, 2002, 'Effects of base material, plasma proteins and FGF2 on endothelial cell adhesion and growth', Journal of Biomaterials Science, Polymer Edition, 13, pp. 845 - 862, http://dx.doi.org/10.1163/156856202320401924

Journal articles | 2002

Whitelock JM; Iozzo RV, 2002, 'Isolation and purification of proteoglycans', Methods in Cell Biology, 2002, pp. 53 - 67, http://dx.doi.org/10.1016/S0091-679X(02)69007-7

Journal articles | 2001

Knox S; Melrose J; Whitelock J, 2001, 'Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins', Proteomics, 1, pp. 1534 - 1541, http://dx.doi.org/10.1002/1615-9861(200111)1:12<1534::AID-PROT1534>3.0.CO;2-A

Journal articles | 2001

Underwood PA; Bean PA; Mitchell SM; Whitelock JM, 2001, 'Specific affinity depletion of cell adhesion molecules and growth factors from serum', Journal of Immunological Methods, 247, pp. 217 - 224, http://dx.doi.org/10.1016/S0022-1759(00)00327-6

Journal articles | 2001

Whitelock J, 2001, 'Purification of perlecan from endothelial cells.', Methods in molecular biology (Clifton, N.J.), 171, pp. 27 - 34

Journal articles | 2000

Mongiat M; Taylor K; Otto J; Aho S; Uitto J; Whitelock JM; Iozzo RV, 2000, 'The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7', Journal of Biological Chemistry, 275, pp. 7095 - 7100, http://dx.doi.org/10.1074/jbc.275.10.7095

Journal articles | 2000

Whitelock J; Bean P; Knox S; Graham L; Mitchell S; Underwood A, 2000, 'The purification and characterization of recombinant domain I of perlecan expressed in HEK-293 cells', Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, pp. 112

Journal articles | 1999

Graham LD; Whitelock JM; Underwood PA, 1999, 'Expression of human perlecan domain I as a recombinant heparan sulfate proteoglycan with 20-kDa glycosaminoglycan chains', Biochemical and Biophysical Research Communications, 256, pp. 542 - 548, http://dx.doi.org/10.1006/bbrc.1999.0377

Journal articles | 1999

Whitelock J; Mitchell S; Underwood PA, 1999, 'Erratum: The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth (Cell Biology International (1997) 21 (181-189))', Cell Biology International, 23, pp. 451, http://dx.doi.org/10.1006/cbir.1999.0353

Journal articles | 1999

Whitelock JM; Graham LD; Melrose J; Murdoch AD; Iozzo RV; Anne Underwood P, 1999, 'Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells', Matrix Biology, 18, pp. 163 - 178, http://dx.doi.org/10.1016/S0945-053X(99)00014-1

Journal articles | 1998

Melrose J; Whitelock J; Xu Q; Ghosh P, 1998, 'Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells', Journal of Vascular Surgery, 28, pp. 676 - 686, http://dx.doi.org/10.1016/S0741-5214(98)70094-1

Journal articles | 1998

Sharma B; Handler M; Eichstetter I; Whitelock JM; Nugent MA; Iozzo RV, 1998, 'Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo', Journal of Clinical Investigation, 102, pp. 1599 - 1608, http://dx.doi.org/10.1172/JCI3793

Journal articles | 1998

Underwood PA; Bean PA; Whitelock JM, 1998, 'Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: Role of type V collagen', Atherosclerosis, 141, pp. 141 - 152, http://dx.doi.org/10.1016/S0021-9150(98)00164-6

Journal articles | 1998

Underwood PA; Mitchell SM; Whitelock JM, 1998, 'Heparin fails to inhibit the proliferation of human vascular smooth muscle cells in the presence of human serum', Journal of Vascular Research, 35, pp. 449 - 460, http://dx.doi.org/10.1159/000025616

Journal articles | 1997

Graham LD; Hayward IP; Fitzgerald M; Whitelock JM; Bingley JA; Campbell JH; Underwood PA, 1997, 'Inhibition of phenotype modulation, growth, and migration of vascular smooth muscle cells by a guanosine-rich 30-mer phosphorothioate oligodeoxynucleotide', Cell Biology International, 21, pp. 585 - 594, http://dx.doi.org/10.1006/cbir.1997.0189

Journal articles | 1997

Whitelock J; Mitchell S; Underwood PA, 1997, 'The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth', Cell Biology International, 21, pp. 181 - 189, http://dx.doi.org/10.1006/cbir.1996.0125

Journal articles | 1996

Whitelock JM; Murdoch AD; Iozzo RV; Underwood PA, 1996, 'The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases', Journal of Biological Chemistry, 271, pp. 10079 - 10086, http://dx.doi.org/10.1074/jbc.271.17.10079

Journal articles | 1993

Gibbins JR; Paine ML; Whitelock JM; O'Grady RL; Kefford RF, 1993, 'Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression', Journal of the National Cancer Institute, 85, pp. 1425 - 1427, http://dx.doi.org/10.1093/jnci/85.17.1425

Journal articles | 1993

Lyons JG; Birkedal-Hansen B; Pierson MC; Whitelock JM; Birkedal-Hansen H, 1993, 'Interleukin-1β and transforming growth factor-α/epidermal growth factor induce expression of Mr 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes', Journal of Biological Chemistry, 268, pp. 19143 - 19151

Journal articles | 1993

WHITELOCK JM; PAINE ML; GIBBINS JR; KEFFORD RF; O'GRADY RL, 1993, 'Multiple levels of post‐transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line', Immunology and Cell Biology, 71, pp. 39 - 47, http://dx.doi.org/10.1111/j.1440-1711.1993.tb03386.x

Journal articles | 1992

Nethery A; Giles I; Jenkins K; Jackson C; Brooks P; Burkhardt D; Ghosh P; Whitelock J; O'Grady RL; Welgus HG; Schrieber L, 1992, 'The chondroprotective drugs, arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro', Biochemical Pharmacology, 44, pp. 1549 - 1553, http://dx.doi.org/10.1016/0006-2952(92)90471-T

Journal articles | 1992

Whitelock JM; O'Grady RL, 1992, 'The production of collagenase and an inhibitor of collagenase by rat mammary carcinoma cells.', Matrix (Stuttgart, Germany). Supplement, 1, pp. 413 - 414

Journal articles | 1991

Whitelock JM; O'Grady RL; Gibbins JR, 1991, 'Interstitial collagenase (matrix metalloproteinase 1) associated with the plasma membrane of both neoplastic and nonneoplastic cells', Invasion and Metastasis, 11, pp. 139 - 148

Journal articles | 1991

Whitelock JM; O'Grady RL; Gibbins JR, 1991, 'Interstitial collagenase (matrix metalloproteinase 1) associated with the plasma membrane of both neoplastic and nonneoplastic cells', Invasion and Metastasis, 11, pp. 139 - 148

Journal articles | 1991

Whitelock JM; O'Grady RL; Gibbins JR, 1991, 'The identification, purification and characterisation of an inhibitor of collagenase (20K) produced by neoplastic epithelial cells', BBA - General Subjects, 1073, pp. 107 - 113, http://dx.doi.org/10.1016/0304-4165(91)90189-N

Journal articles | 1989

Whitelock JM; O'Grady RL; Lyons JG, 1989, 'Immunolocalization of collagenase in neoplastic epithelial cells', Immunology and Cell Biology, 67, pp. 349 - 357, http://dx.doi.org/10.1038/icb.1989.51
Preprints | 2022

Chen K; Yong J; Zauner R; Wally V; Whitelock J; Sajinovic M; Kopecki Z; Liang K; Scott K; Mellick AS, 2022, Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma, , http://dx.doi.org/10.20944/preprints202211.0160.v1

Conference Abstracts | 2021

Johnson BB; Holmes TL; Thompson JL; Lord M; Denning C; Whitelock J; Merry CLR; Smith J, 2021, 'A CRISPR/Cas9 in vitro human-induced pluripotent stem cell (hiPSC) model to investigate the role of perlecan in cardiovascular fibrotic disease', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, Vol. 102, pp. 126 - 127, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000630872200029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2018

Elgundi Z; Freelander A; Bean P; Whitelock J; Lord M, 2018, 'Investigating the roles of perlecan using antibodies with unique epitopes', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, ENGLAND, Manchester, Vol. 99, pp. A23 - A23, presented at Matrix Biology Europe Meeting, ENGLAND, Manchester, 21 July 2018 - 24 July 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459467900046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2018

Smith J; Merry C; Lord M; Denning C; Whitelock J, 2018, 'Developing an in vitro human induced pluripotent stem cell (hiPSC) model using CRISPR/Cas9 to investigate the role of perlecan in fibrosis', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, ENGLAND, Manchester, Vol. 99, pp. A20 - A21, presented at Matrix Biology Europe Meeting, ENGLAND, Manchester, 21 July 2018 - 24 July 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459467900041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Thompson J; Ashworth J; Whitelock J; Merry C, 2017, 'Modelling the brain tumour microenvironment', in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY, ENGLAND, Univ Oxford, Oxford, Vol. 98, pp. A22 - A22, presented at Spring Meeting of the British-Society-for-Matrix-Biology (BSMB), ENGLAND, Univ Oxford, Oxford, 03 April 2017 - 04 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408620000047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2016

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2016, 'The potent inflammatory oxidant, peroxynitrite, modifies the extracellular matrix of human atherosclerotic lesions', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, HUNGARY, Budapest, pp. S45 - S45, presented at Conference of the Society-for-Free-Radical-Research-Europe (SFRR-E), HUNGARY, Budapest, 08 June 2016 - 11 June 2016, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.093

Conference Abstracts | 2016

Farrugia BL; Whitelock J; LORD M, 2016, 'The inflammatory response to implanted materials, fibrous capsule characterisation', in Front. Bioeng. Biotechnol., presented at 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016., http://dx.doi.org/10.3389/conf.FBIOE.2016.01.00994

Conference Abstracts | 2016

Farrugia BL; Whitelock J; Lord M, 2016, 'CHITOSAN SULPHATE: ENGINEERING A BIOMIMETIC GROWTH FACTOR DELIVERY SYSTEM', in Wound Repair and Regeneration, Wiley, Melbourne, Australia, Vol. 24, pp. A13 - A30, presented at Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne, Australia, 07 November 2016 - 09 November 2016, http://dx.doi.org/10.1111/wrr.12489

Conference Abstracts | 2016

Farrugia BL; whitelock J; LORD M, 2016, 'Chitosan sulfate: engineering a biomimetic growth factor delivery system', in Front. Bioeng. Biotechnol., Frontiers, Vol. 4, pp. A18 - A18, presented at 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016, http://dx.doi.org/10.3389/conf.fbioe.2016.01.01019

Conference Abstracts | 2016

Lord M; Whitelock J; Cheng B; Tang F; Lyons G, 2016, 'Bioengineering of human heparin: A next generation anti-coagulant', in The FASEB Journal, Federation of American Society of Experimental Biology (FASEB), San Diego, Vol. 30, pp. 1070.5 - 1070.5, presented at Experimental Biology 2016 Meeting, San Diego, 02 April 2016 - 06 April 2016, http://dx.doi.org/10.1096/fasebj.30.1_supplement.1070.5

Conference Abstracts | 2016

Lord M; chuang C; rnjak-kovacina J; cheng B; lyons G; whitelock J, 2016, 'Bioengineering proteoglycan-based matrices for blood contacting applications', in The FASEB Journal, Federation of American Society of Experimental Biology (FASEB), San Diego, Vol. 6, pp. 622.2 - 622.2, presented at Experimental Biology 2016, San Diego, 02 April 2016 - 06 April 2016

Conference Abstracts | 2016

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Domain V of Perlecan Covalently Immobilized on Silk Biomaterials Modulates Endothelial Cell and Platelet Interactions for Vascular Applications', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, CA, San Diego, Vol. 22, pp. S20 - S21, presented at TERMIS - Americas Conference and Exhibition, CA, San Diego, 11 December 2016 - 14 December 2016

Conference Abstracts | 2016

Tang F; Lau K; Kondyurin A; Lord MS; Whitelock JM; Bilek MM; Rnjak-Kovacina J, 2016, 'Plasma Immersion Ion Implantation Treatment of Silk Biomaterials Enhances Biological Function'

Conference Abstracts | 2015

Gunatillake T; Chui A; Lord M; Whitelock J; Murthi P; Ignatovic V; Monagle P; Brennecke S; Said J, 2015, '[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.', http://dx.doi.org/10.1016/j.preghy.2014.10.295

Conference Abstracts | 2014

Whitelock J; Jung M; Cheng B; Lord M, 2014, 'Transcriptional regulation and proteolytic processing of perlecan in mast cells lead to the production of forms that contain the alpha2/beta1 integrin binding site: roles in wound healing and tissue regeneration', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, Vol. 28, presented at Experimental Biology Meeting, CA, San Diego, 26 April 2014 - 30 April 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346646701331&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2012

Chuang CY; Degendorfer G; Hammer A; Malle E; Whitelock JM; Davies MJ, 2012, 'Peroxynitrite Modulates Endothelial Cell-Derived Extracellular Matrix in Human Atherosclerotic Lesions', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, CA, San Diego, pp. S134 - S134, presented at 19th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM), CA, San Diego, 14 November 2012 - 18 November 2012, http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.364

Conference Abstracts | 2012

Jung M; Lord M; Cheng B; Lyons JG; Alkhouri H; Hughes JM; McCarthy S; Iozzo R; Whitelock J, 2012, 'Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: A role in angiogenesis and wound healing', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, CA, San Diego, Vol. 22, pp. 1627 - 1628, presented at Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology, CA, San Diego, 11 November 2012 - 14 November 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310368700326&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2012

Lord M; Day A; Youssef P; Zhuo L; Watanabe H; Caterson B; Whitelock J, 2012, 'Chondroitin sulfate-mediated stabilization of hyaluronan-rich matrices', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, CA, San Diego, Vol. 22, pp. 1627 - 1627, presented at Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology, CA, San Diego, 11 November 2012 - 14 November 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310368700324&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2012

Penm S; Lord MS; O'Grady R; Whitelock J, 2012, 'Expression of matrix components in liver cells: Studies in human hepatocytes (HepG2) and hepatic stellate cells (LX-2)', in Glycobiology, Vol. 22, pp. 1546 - 1547, http://dx.doi.org/10.1093/glycob/cws127

Conference Abstracts | 2012

Tang F; Lord M; Whitelock J, (ed.), 2012, 'The roles of melanoma-associated protein (CSPG4) and perlecan (HSPG2) in cancer, potential targets for drug therapy', in Glycobiology, Vol. 22, pp. 1605 - 1605

Conference Abstracts | 2012

Whitelock JM; Jung MS; Chuang CY; Cheng B; Koo T; Lyons JG; Lord MS, 2012, 'Shorter forms of the proteoglycan, Perlecan; Adding complexity to an already complex molecule', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, Vol. 26, presented at Experimental Biology Meeting, CA, San Diego, 21 April 2012 - 25 April 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310711305959&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations | 2011

Young C; Cheng J; Whitelock J; Martens P; Poole-Warren L, 2011, 'Islet matrix identification for use in biosynthetic microencapsulation'

Conference Papers | 2010

Kennett E; Chuang CY; Degendorfer G; Rees MD; Hammer A; Malle E; Whitelock JM; Davies MJ, 2010, 'Extracellular Matrix Proteoglycans are a Major Target for Peroxynitrite in the Artery Wall', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, FL, Orlando, pp. S113 - S113, presented at 17th Annual Meeting of the Society-for-Free-Radical-Biology-Medicine /15th Biennial Meeting of the Society-for-Free-Radical-Research-International, FL, Orlando, 17 November 2010 - 21 November 2010, http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.302

Conference Papers | 2009

Kennett EC; Rees MD; Whitelock JM; Davies MJ, 2009, 'Peroxynitrite Modifies the Structure and Function of the Extracellular Matrix Proteoglycan Perlecan by Reaction with both the Protein Core and the Heparan Sulfate Chains', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, CA, San Francisco, pp. S73 - S74, presented at 16th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine, CA, San Francisco, 18 November 2009 - 22 November 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271988500207&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations | 2009

Martens P; Nilasaroya A; Reeves A; Kundu ; Kundu S; Whitelock J; Poole-Warren LA, 2009, 'Poly (Vinyl Alcohol) Hydrogels: Improving Biological Performance', presented at European Society for Biomaterials 2009, Lausanne, Switzerland

Conference Presentations | 2009

Martens P; Nilasaroya A; Whitelock J; Poole-Warren LA, 2009, 'Biosynthetic Hydrogel Composite Materials: Maintaining Network Structure and Improving Biological Performance', presented at Biomaterials Asia, Hong Kong, -

Conference Papers | 2009

Melrose C; Knox SM; Iozzo R; Whitelock J; Chuang CY, 2009, 'The role of heparan sulfate on chondrocyte perlecan - to proliferate or not?', in International Journal of Experimental Pathology, Blackwell Publishing Ltd, Oxford, England, pp. A102 - A103, presented at Annual General Meeting of the British-Society-for-Matrix-Biology, York Univ, York, ENGLAND, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264345300021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Presentations | 2009

Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2009, 'Poly(Vinyl Aochol)-Heparin Hydrogels: Growth Factor Activation and Degradation', presented at BITE&RM and Australasian Society for Biomaterials and Tissue Engineering 2009, Sydney, Australia

Conference Abstracts | 2008

Lord M; Ma J; Davies N; Chuang C; Nielsen N; Iozzo R; Whitelock J, 2008, 'Modulation of biosignalling using recombinant heparan sulfate', in 8th World Biomaterials Congress 2008, Vol. 3, pp. 1237

Conference Posters | 2008

Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2008, 'Structural and Functional Characterisation of Poly (Vinyl Alcohol) and Heparin Copolymers', Canberra, Australia, presented at 18th Annual Australasian Society for Biomaterials and Tissue Engineering Conference, Canberra, Australia, 22 February 2008 - 22 February 2008

Conference Presentations | 2008

Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2008, 'Structural and Functional Characterization of Poly (Vinyl Alcohol) and Heparin Copolymers', Vol. 2, pp. 872, presented at World Biomaterials Congress, Amsterdam, Netherlands

Conference Presentations | 2007

Martens P; Whitelock J; Poole-Warren LA, 2007, 'Characterisation of Redox Polymerised Poly (Vinyl Alcohol) Hydrogels', presented at International Congress on Biohydrogels, Viareggio, Italy

Conference Presentations | 2007

Martens P; Whitelock J; Poole-Warren LA, 2007, 'Redox Initiated Hydrogels for Tissue Engineering Applications', presented at Australasian Society for Biomaterials and Tissue Engineering 2007, Mt Eliza, Australia, -

Conference Presentations | 2007

Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2007, 'Characterisation of Poly(Vinyl Alcohol) and Heparin Hydrogels Formed from Methacrylated Macromers', presented at Australasian Society for Biomaterials and Tissue Engineering 2007, Mt Eliza, Australia, -

Conference Presentations | 2007

Nilasaroya A; Poole-Warren LA; Whitelock J; Martens P, 2007, 'Network Formation of Poly(Vinyl Alcohol)-Heparin Hydrogels', presented at International Congress on Biohydrogels, Viareggio, Italy

Conference Presentations | 2007

Poole-Warren LA; Nilasaroya A; Grant M; Whitelock J; Martens P, 2007, 'Biosynthetic Hydrogels as injectable soft-tissue engineering scaffolds', presented at TERMIS-AP, Tokyo, Japan

Conference Papers | 2007

Rees M; Chuang CY; Whitelock J; Davies MJ, 2007, 'Oxidative degradation of perlecan, a key matrix proteoglycan, by myclopcroxidase-derived oxidants and its consequences', in Free Radical Research, Taylor & Francis Ltd, Abingdon, England, pp. S49 - S49, presented at SFRR-Europe, Vilamoura, PORTUGAL, 10 October 2007 - 13 October 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252296300182&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Presentations | 2007

Whitelock J; Davies N; Jung M; Nilasaroya A; Chuang C; Neilsen N; Martens P, 2007, 'Heparan Sulfate as a Biosignalling Molecule for Tissue Engineering Applications', presented at TERMIS-AP, Tokyo, Japan

Conference Proceedings (Editor of) | 2004

Chau N; Poole-Warren LA; Whitelock J, (eds.), 2004, '7th World Biomaterials Congress', Sydney, presented at 7th World Biomaterials Congress, Sydney, 17 May 2004 - 21 May 2004

Conference Proceedings (Editor of) | 2004

Whitelock J; Karlsson N; Melrose J; Knox SM; Schulz B; Packer N; Last K; Fosang A, (eds.), 2004, 'Matrix Biology Society of Australia and New Zealand', Rottnest Island, WA, presented at Matrix Biology Society of Australia and New Zealand, Rottnest Island, WA

Conference Proceedings (Editor of) | 2004

Whitelock J; Karlsson N; Melrose J; Knox SM; Schulz B; Robinson L; Packer N; Last K; Fosang A, (eds.), 2004, 'Gordon Conference on Proteoglycans', New Hampshire, USA, presented at Gordon Conference on Proteoglycans, New Hampshire, USA

Conference Proceedings (Editor of) | 2003

Melrose J; Smith SA; Ghosh P; Whitelock J, (eds.), 2003, 'Orthopedic Research Society', Orleans, USA, presented at Orthopedic Research Society, Orleans, USA

Conference Proceedings (Editor of) | 2003

Whitelock J; Schulz B; Knox SM; Melrose J; Packer N, (eds.), 2003, 'Osteoarthritis Research Society International', Berlin, Germany, presented at Osteoarthritis Research Society International, Berlin, Germany

Follow

Emeritus Professor John Whitelock