Dr Johnson Jianzhong Liu
Senior Lecturer

Dr Johnson Jianzhong Liu

 

  • BSc, MSc (Veterinary Medicine) Northwest A & F University
  • PhD (Pharmacology) South China Agricultural University
  • GCULT (Grad Cert in University Learning & Teaching), UNSW
medicine-health
School of Medical Sciences

Research Interests:

The broad interest of the lab is concerning cancer pharmacology, experimental therapeutics, targeted cancer therapy, pharmacokinetics, drug transport, chemotherapy-induced neuropathy and caner risk related genetic polymorphisms. In particular, we have been involving in the preclinical development of anticancer agents, including small molecules targeting Wnt signalling, copper chelators, platinum/gold/silver-based complexes, vascular-disrupting flavonoids and mulberry fruit extracts using a variety of in vitro and in vivo approaches. We are among the first to identify the links of copper transporters and organic cation transporters with chemotherapy-induced neurotoxicity, and lung cancer risk related genetic polymorphisms in Chinese Han population. We have current research projects for PhD, Masters, Honours and ILP students on the topics of targeting Wnt signalling and drug transporters in cancer therapy.

Membership:

  • Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists
  • Australasian Clinical Trials Alliance
  • American Association for Cancer Research
Phone
02-9385 9086

Publications

  • Journal articles | 2021
    Dr Johnson Jianzhong Liu
    Sui X; Jiao YN; Yang LH; Liu J, 2021, 'MiR-9 accelerates epithelial-mesenchymal transition of ovarian cancer cells via inhibiting e-cadherin', European Review for Medical and Pharmacological Sciences, vol. 23, pp. 209 - 216, http://dx.doi.org/10.26355/eurrev_201908_18649
    Journal articles | 2020
    Dr Johnson Jianzhong Liu
    Zuo Y; Zheng W; Liu J; Tang Q; Wang SS; Yang XS, 2020, 'Mir-34a-5p/pd-l1 axis regulates cisplatin chemoresistance of ovarian cancer cells', Neoplasma, vol. 67, pp. 93 - 101, http://dx.doi.org/10.4149/neo_2019_190202N106
    Journal articles | 2020
    Dr Johnson Jianzhong Liu
    Xue YF; Xue D; Yao B; Hu CG; Liu J, 2020, 'Correlation between microRNA-766 expression in patients with advanced gastric cancer and the efficacy of platinum-containing chemotherapy', European Review for Medical and Pharmacological Sciences, vol. 24, pp. 8822 - 8829, http://dx.doi.org/10.26355/eurrev_202009_22821
    Journal articles | 2020
    Dr Johnson Jianzhong Liu
    Zhang PP; Li LL; Han X; Li QW; Zhang XH; Liu JJ; Wang Y, 2020, 'Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice', Acta Pharmacologica Sinica, vol. 41, pp. 678 - 685, http://dx.doi.org/10.1038/s41401-019-0330-9
    Journal articles | 2020
    Dr Johnson Jianzhong Liu
    Yang T; Li M; Li H; Shi P; Liu J; Chen M, 2020, 'Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation', Biochemical and Biophysical Research Communications, vol. 530, pp. 348 - 354, http://dx.doi.org/10.1016/j.bbrc.2020.06.106
    Journal articles | 2019
    Dr Johnson Jianzhong Liu
    Lin J; Xu Y; Wang Y; Huang S; Li J; Meti MD; Xu X; Hu Z; Liu J; He Z; Xu H, 2019, 'Dissection of binding of trypsin to its natural inhibitor Gensenoside-Rg1 using spectroscopic methods and molecular modeling', Journal of Biomolecular Structure and Dynamics, vol. 37, pp. 4070 - 4079, http://dx.doi.org/10.1080/07391102.2018.1539411
    Journal articles | 2019
    Dr Johnson Jianzhong Liu
    Myint K; Biswas R; Li Y; Jong N; Jamieson S; Liu J; Han C; Squire C; Merien F; Lu J; Nakanishi T; Tamai I; McKeage M, 2019, 'Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-38667-8
    Journal articles | 2019
    Dr Johnson Jianzhong Liu
    Zhang J; Tian ZL; Zhang WT; Cheng LM; Liu J; Cao YX; Zhang ZR, 2019, 'Clinicopathological and prognostic significance of miR-4317 expression in gastric cancer patients', European Review for Medical and Pharmacological Sciences, vol. 23, pp. 2803 - 2808, http://dx.doi.org/10.26355/eurrev_201904_17555
    Journal articles | 2019
    Dr Johnson Jianzhong Liu
    Biswas R; Bugde P; He J; Merien F; Lu J; Liu DX; Myint K; Liu J; McKeage M; Li Y, 2019, 'Transport-mediated oxaliplatin resistance associated with endogenous overexpression of MRP2 in Caco-2 and PANC-1 Cells', Cancers, vol. 11, http://dx.doi.org/10.3390/cancers11091330
    Journal articles | 2018
    Dr Johnson Jianzhong Liu
    Meti MD; Xu Y; Xie J; Chen Y; Wu Z; Liu J; Han Q; He Z; Hu Z; Xu H, 2018, 'Multi-spectroscopic studies on the interaction between traditional Chinese herb, helicid with pepsin', Molecular Biology Reports, vol. 45, pp. 1637 - 1646, http://dx.doi.org/10.1007/s11033-018-4306-5
    Journal articles | 2017
    Dr Johnson Jianzhong Liu
    Cui H; Zhang AJ; McKeage MJ; Nott LM; Geraghty D; Guven N; Liu JJ, 2017, 'Copper transporter 1 in human colorectal cancer cell lines: Effects of endogenous and modified expression on oxaliplatin cytotoxicity', Journal of Inorganic Biochemistry, vol. 177, pp. 249 - 258, http://dx.doi.org/10.1016/j.jinorgbio.2017.04.022
    Journal articles | 2016
    Dr Johnson Jianzhong Liu
    Zhang S; Gao L; Thakur A; Shi P; Liu F; Feng J; Wang T; Liang Y; Liu JJ; Chen M; Ren H, 2016, 'miRNA-204 suppresses human non-small cell lung cancer by targeting ATF2', Tumor Biology, vol. 37, pp. 11177 - 11186, http://dx.doi.org/10.1007/s13277-016-4906-4
    Journal articles | 2016
    Dr Johnson Jianzhong Liu
    Ren H; Guo H; Thakur A; Zhang S; Wang T; Liang Y; Shi P; Gao L; Liu F; Feng J; Chen T; Yang T; Shang D; Liu JJ; Xu F; Chen M, 2016, 'Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells', Oncotarget, vol. 7, pp. 67277 - 67287, http://dx.doi.org/10.18632/oncotarget.11645
    Journal articles | 2015
    Dr Johnson Jianzhong Liu
    Yan F; Liu JJ; Ip V; Jamieson SMF; Mckeage MJ, 2015, 'Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity', Journal of Neurochemistry, http://dx.doi.org/10.1111/jnc.13355
    Journal articles | 2015
    Dr Johnson Jianzhong Liu
    Cui H; Zhang AJ; Chen M; Liu JJ, 2015, 'ABC transporter inhibitors in reversing multidrug resistance to chemotherapy', Current Drug Targets, vol. 16, pp. 1356 - 1371, http://dx.doi.org/10.2174/1389450116666150330113506
    Journal articles | 2015
    Dr Johnson Jianzhong Liu
    Qian Z; Wu Z; Huang L; Qiu H; Wang L; Li L; Yao L; Kang K; Qu J; Wu Y; Luo J; Liu JJ; Yang Y; Yang W; Gou D, 2015, 'Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep17348
    Journal articles | 2015
    Dr Johnson Jianzhong Liu
    Zhang S; Thakur A; Liang Y; Wang T; Gao L; Yang T; Li Y; Geng T; Jin T; Chen T; Liu JJ; Chen M, 2015, 'Polymorphisms in C-reactive protein and glypican-5 are associated with lung cancer risk and gartrokine-1 influences cisplatin-based chemotherapy response in a Chinese Han population', Disease Markers, vol. 2015, http://dx.doi.org/10.1155/2015/824304
    Journal articles | 2015
    Dr Johnson Jianzhong Liu
    Wang T; Chen T; Thakur A; Liang Y; Gao L; Zhang S; Tian Y; Jin T; Liu JJ; Chen M, 2015, 'Association of PSMA4 polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population', Clinical and Translational Oncology, vol. 17, pp. 564 - 569, http://dx.doi.org/10.1007/s12094-015-1279-x
    Journal articles | 2015
    Dr Johnson Jianzhong Liu
    Yan F; Liu JJ; Ip V; Jamieson SMF; McKeage MJ, 2015, 'Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity', Journal of Neurochemistry, vol. 135, pp. 1099 - 1112, http://dx.doi.org/10.1111/jnc.13355
    Journal articles | 2014
    Dr Johnson Jianzhong Liu
    Gao L; Thakur A; Liang Y; Zhang S; Wang T; Chen T; Meng J; Wang L; Wu F; Jin T; Li X; Liu JJ; Chen C; Chen M, 2014, 'Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population', European Journal of Cancer Prevention, vol. 23, pp. 497 - 501, http://dx.doi.org/10.1097/CEJ.0000000000000086
    Journal articles | 2014
    Dr Johnson Jianzhong Liu
    Chen M; Zhou ZY; Chen JG; Tong N; Chen SQ; Yang Y; Zhang XW; Jiang H; Liu N; Liu J; Sha GZ; Zhu WD; Hua LX; Wang ZJ; Xu B, 2014, 'Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population', Genetics and Molecular Research, vol. 13, pp. 10615 - 10621, http://dx.doi.org/10.4238/2014.December.18.3
    Journal articles | 2013
    Dr Johnson Jianzhong Liu
    Liu JJ; Kim Y; Yan F; Ding Q; Ip V; Jong NN; Mercer JFB; McKeage MJ, 2013, 'Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons', Biochemical Pharmacology, vol. 85, pp. 207 - 215, http://dx.doi.org/10.1016/j.bcp.2012.10.023
    Journal articles | 2013
    Dr Johnson Jianzhong Liu
    Ip V; Liu JJ; Mckeage MJ, 2013, 'Evaluation of effects of copper histidine on copper transporter 1-mediated accumulation of platinum and oxaliplatin-induced neurotoxicity in vitro and in vivo', Clinical and Experimental Pharmacology and Physiology, vol. 40, pp. 371 - 378, http://dx.doi.org/10.1111/1440-1681.12088
    Journal articles | 2012
    Dr Johnson Jianzhong Liu
    Liu JJ; Lu J; McKeage MJ, 2012, 'Membrane transporters as determinants of the pharmacology of platinum anticancer drugs', Current Cancer Drug Targets, vol. 12, pp. 962 - 986, http://dx.doi.org/10.2174/156800912803251199
    Journal articles | 2012
    Dr Johnson Jianzhong Liu
    Wang AX; Xu B; Tong N; Chen SQ; Yang Y; Zhang XW; Jiang H; Liu N; Liu J; Hu XN; Sha GZ; Chen M, 2012, 'Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors.', Genetics and molecular research : GMR, vol. 11, pp. 3051 - 3062, http://dx.doi.org/10.4238/2012.August.31.2
    Journal articles | 2011
    Dr Johnson Jianzhong Liu
    Jong NN; Nakanishi T; Liu JJ; Tamai I; McKeage MJ, 2011, 'Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons', Journal of Pharmacology and Experimental Therapeutics, vol. 338, pp. 537 - 547, http://dx.doi.org/10.1124/jpet.111.181297
    Journal articles | 2011
    Dr Johnson Jianzhong Liu
    Jong NN; Nakanishi T; Liu JJ; Tamai I; McKeage MJ, 2011, 'OCTN1-and OCTN2-mediated uptake of oxaliplatin in rat dorsal root ganglion neurons and HEK293 cells over-expressing OCTN1 or OCTN2', CANCER RESEARCH, vol. 71, http://dx.doi.org/10.1158/1538-7445.AM2011-4391
    Journal articles | 2011
    Dr Johnson Jianzhong Liu
    Liu JJ; Kim Y; Mercer JFB; McKeage MJ, 2011, 'Copper and platinum uptake in cultured rat dorsal root ganglion neurons', CANCER RESEARCH, vol. 71, http://dx.doi.org/10.1158/1538-7445.AM2011-4389
    Journal articles | 2010
    Dr Johnson Jianzhong Liu
    Ip V; Liu JJ; Mercer JFB; McKeage MJ, 2010, 'Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue', Molecular Pain, vol. 6, http://dx.doi.org/10.1186/1744-8069-6-53
    Journal articles | 2009
    Dr Johnson Jianzhong Liu
    Jamieson SMF; Subramaniam J; Liu JJ; Jong NN; Ip V; Connor B; McKeage MJ, 2009, 'Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue', Molecular Pain, vol. 5, http://dx.doi.org/10.1186/1744-8069-5-66
    Journal articles | 2009
    Dr Johnson Jianzhong Liu
    Liu JJ; Jamieson SMF; Subramaniam J; Ip V; Jong NN; Mercer JFB; McKeage MJ, 2009, 'Neuronal expression of copper transporter 1 in rat dorsal root ganglia: Association with platinum neurotoxicity', Cancer Chemotherapy and Pharmacology, vol. 64, pp. 847 - 856, http://dx.doi.org/10.1007/s00280-009-1017-6
    Journal articles | 2008
    Dr Johnson Jianzhong Liu
    Ip V; McKeage MJ; Thompson P; Damianovich D; Findlay M; Liu JJ, 2008, 'Platinum-specific detection and quantification of oxaliplatin and Pt(R,R-diaminocyclohexane)Cl2 in the blood plasma of colorectal cancer patients', Journal of Analytical Atomic Spectrometry, vol. 23, pp. 881 - 884, http://dx.doi.org/10.1039/b716925f
    Journal articles | 2008
    Dr Johnson Jianzhong Liu
    Liu JJ; Galettis P; Farr A; Maharaj L; Samarasinha H; McGechan AC; Baguley BC; Bowen RJ; Berners-Price SJ; McKeage MJ, 2008, 'In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake', Journal of Inorganic Biochemistry, vol. 102, pp. 303 - 310, http://dx.doi.org/10.1016/j.jinorgbio.2007.09.003
    Journal articles | 2008
    Dr Johnson Jianzhong Liu
    Bell DN; Liu JJ; Tingle MD; Rattel B; Meyer TU; McKeage MJ, 2008, 'Comparative protein binding, stability and degradation of satraplatin, JM118 and cisplatin in human plasma in vitro', Clinical and Experimental Pharmacology and Physiology, vol. 35, pp. 1440 - 1446, http://dx.doi.org/10.1111/j.1440-1681.2008.05017.x
    Journal articles | 2007
    Dr Johnson Jianzhong Liu
    Jamieson SMF; Liu JJ; Connor B; Dragunow M; McKeage MJ, 2007, 'Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel', NeuroToxicology, vol. 28, pp. 1092 - 1098, http://dx.doi.org/10.1016/j.neuro.2007.04.009
    Journal articles | 2007
    Dr Johnson Jianzhong Liu
    Liu JJ; Ching LM; Goldthorpe M; Sutherland R; Baguley BC; Kirker JA; McKeage MJ, 2007, 'Antitumour action of 5,6-dimethylxanthenone-4-acetic acid in rats bearing chemically induced primary mammary tumours', Cancer Chemotherapy and Pharmacology, vol. 59, pp. 661 - 669, http://dx.doi.org/10.1007/s00280-006-0321-7
    Journal articles | 2006
    Dr Johnson Jianzhong Liu
    Jiang HX; Zeng ZL; Chen ZL; Liu JJ; Fung KF, 2006, 'Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing', Journal of Veterinary Pharmacology and Therapeutics, vol. 29, pp. 153 - 156, http://dx.doi.org/10.1111/j.1365-2885.2006.00727.x
    Journal articles | 2006
    Dr Johnson Jianzhong Liu
    Bell DN; Liu JJ; Tingle MD; McKeage MJ, 2006, 'Specific determination of intact cisplatin and monohydrated cisplatin in human plasma and culture medium ultrafiltrates using HPLC on-line with inductively coupled plasma mass spectrometry', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 837, pp. 29 - 34, http://dx.doi.org/10.1016/j.jchromb.2006.03.063
    Journal articles | 2006
    Dr Johnson Jianzhong Liu
    Liu JJ; Ching L-M; Goldthorpe M; Sutherland R; Baguley BC; Kirker JA; McKeage MJ, 2006, 'Antitumour action of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in rats bearing chemically-induced primary mammary tumours', ACTA PHARMACOLOGICA SINICA, vol. 27, pp. 70 - 70, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239590000413&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2005
    Dr Johnson Jianzhong Liu
    Jamieson SMF; Liu J; Connor B; McKeage MJ, 2005, 'Oxaliplatin causes selective atrophy of a subpopulation of dorsal root ganglion neurons without inducing cell loss', Cancer Chemotherapy and Pharmacology, vol. 56, pp. 391 - 399, http://dx.doi.org/10.1007/s00280-004-0953-4
    Journal articles | 2003
    Dr Johnson Jianzhong Liu
    Liu J; Fung KF; Chen Z; Zeng Z; Zhang J, 2003, 'Pharmacokinetics of florfenicol in healthy pigs and in pigs experimentally infected with Actinobacillus pleuropneumoniae', Antimicrobial Agents and Chemotherapy, vol. 47, pp. 820 - 823, http://dx.doi.org/10.1128/AAC.47.2.820-823.2003
    Journal articles | 2003
    Dr Johnson Jianzhong Liu
    Jamieson SMF; Liu J; Hsu T; Baguley BC; McKeage MJ, 2003, 'Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity', British Journal of Cancer, vol. 88, pp. 1942 - 1947, http://dx.doi.org/10.1038/sj.bjc.6601012
  • Conference Papers | 2004
    Dr Johnson Jianzhong Liu
    Liu JJ; Kestell P; Findlay M; Riley G; Ackland S; Simpson A; Isaacs R; McKeage MJ, 2004, 'Application of liquid chromatography-mass spectrometry to monitoring plasma cyclophosphamide levels in phase I trial cancer patients', in Clinical and Experimental Pharmacology and Physiology, pp. 677 - 682, http://dx.doi.org/10.1111/j.1440-1681.2004.03065.x

Awards

Grants

  • Cancer Council Tasmania (2013-2014)
  • Royal Hobart Hospital Foundation (2014-2015)
  • Cancer Society of New Zealand (2010)
  • McBeath Child Cancer Trust (2012)

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