Dr Jonathan Brett

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Jonathan is a staff specialist in clinical pharmacology, toxicology and addiction medicine at St. Vincent's Hospital. He is a conjoint Associate Professor at St. Vincent's Clinical School and a Senior Research Fellow with the Medicines and Health Intelligence Unit at the School of Population Health, UNSW.

Phone

+61283822304

E-mail

j.brett@unsw.edu.au

Location

Medicines and Health Intelligence, School of Population Health, UNSW Sydney St Vincent’s Clinical School, UNSW Medicine, UNSW Sydney Department of Clinical Pharmacology & Toxicology Therapeutics Centre, Level 2 Xavier Building St Vincent’s Hospital Sydney 390 Victoria Street DARLINGHURST NSW 2010 AUSTRALIA

Book Chapters | 2014

Roberts DM; Brett J, 2014, 'Clinical management of acute OP pesticide poisoning', in Basic and Clinical Toxicology of Organophosphorus Compounds, pp. 141 - 175, http://dx.doi.org/10.1007/978-1-4471-5625-3_6
Journal articles | 2023

Carland JE; Stacy AE; Schaffer AL; Day RO; Brett J; Reuter SE; Stocker SL, 2023, 'Blood, dose recommendation reports and phone calls: Experiences of a therapeutic drug monitoring advisory service for vancomycin', British Journal of Clinical Pharmacology, http://dx.doi.org/10.1111/bcp.15668

Journal articles | 2023

Freeman G; Siefried KJ; Roberts DM; Rodgers C; Nic Ionmhain U; Ramanathan J; Ezard N; Brett J, 2023, 'Phenobarbital to manage severe gamma-hydroxybutyrate withdrawal: A case series', Drug and Alcohol Review, vol. 42, pp. 27 - 32, http://dx.doi.org/10.1111/dar.13556

Journal articles | 2022

Acheson LS; Ezard N; Lintzeris N; Dunlop A; Brett J; Rodgers C; Gill A; Christmass M; McKetin R; Farrell M; Shoptaw S; Siefried KJ, 2022, 'Trial protocol of an open label pilot study of lisdexamfetamine for the treatment of acute methamphetamine withdrawal', PLoS ONE, vol. 17, pp. e0275371, http://dx.doi.org/10.1371/journal.pone.0275371

Journal articles | 2022

Brett J; Siefried KJ; Healey A; Harrod ME; Franklin E; Barratt MJ; Masters J; Nguyen L; Adiraju S; Gerber C, 2022, 'Wastewater analysis for psychoactive substances at music festivals across New South Wales, Australia in 2019–2020', Clinical Toxicology, vol. 60, pp. 440 - 445, http://dx.doi.org/10.1080/15563650.2021.1979233

Journal articles | 2022

Bruno C; Havard A; Gillies MB; Coghill D; Brett J; Guastella AJ; Pearson SA; Zoega H, 2022, 'Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)', Australian and New Zealand Journal of Psychiatry, http://dx.doi.org/10.1177/00048674221114782

Journal articles | 2022

Chiew AL; Raubenheimer JE; Berling I; Buckley NA; Becker T; Chan B; Brett J, 2022, 'Just ‘nanging’ around – harmful nitrous oxide use: a retrospective case series and review of Internet searches, social media posts and the coroner's database', Internal Medicine Journal, vol. 52, pp. 1724 - 1732, http://dx.doi.org/10.1111/imj.15391

Journal articles | 2022

Healey A; Siefried KJ; Harrod ME; Franklin E; Peacock A; Barratt MJ; Brett J, 2022, 'Correlates of higher-risk drug-related behaviours at music festivals in New South Wales, Australia', Drug and Alcohol Review, vol. 41, pp. 320 - 329, http://dx.doi.org/10.1111/dar.13404

Journal articles | 2022

Murnion B; Schaffer A; Cairns R; Brett J, 2022, 'Gabapentinoids: repeating mistakes of the past?', Addiction, http://dx.doi.org/10.1111/add.15970

Journal articles | 2022

Page R; Healey A; Siefried KJ; Harrod ME; Franklin E; Peacock A; Barratt MJ; Brett J, 2022, 'Barriers to help-seeking among music festival attendees in New South Wales, Australia', Drug and Alcohol Review, vol. 41, pp. 1322 - 1330, http://dx.doi.org/10.1111/dar.13479

Journal articles | 2022

Schaffer AL; Chia J; Brett J; Pearson S; Falster MO, 2022, 'A nationwide study of multimedicine use in people treated with cardiovascular medicines in Australia', Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, vol. 42, pp. 828 - 836, http://dx.doi.org/10.1002/phar.2735

Journal articles | 2022

Varney B; Zoega H; Gillies MB; Brett J; Pearson SA; Havard A, 2022, 'Prescription opioid use in Australian women of reproductive age: Implications for unplanned pregnancies', British Journal of Clinical Pharmacology, vol. 88, pp. 1298 - 1320, http://dx.doi.org/10.1111/bcp.15074

Journal articles | 2021

Braithwaite HE; Darley DR; Brett J; Day RO; Carland JE, 2021, 'Identifying the association between tacrolimus exposure and toxicity in heart and lung transplant recipients: A systematic review', Transplantation Reviews, vol. 35, http://dx.doi.org/10.1016/j.trre.2021.100610

Journal articles | 2021

Brett J; Pearson SA; Daniels B; Wylie CE; Buckley NA, 2021, 'A cross sectional study of psychotropic medicine use in Australia in 2018: A focus on polypharmacy', British Journal of Clinical Pharmacology, vol. 87, pp. 1369 - 1377, http://dx.doi.org/10.1111/bcp.14527

Journal articles | 2021

Busingye D; Daniels B; Brett J; Pollack A; Belcher J; Chidwick K; Blogg S, 2021, 'Patterns of real-world opioid prescribing in Australian general practice (2013-18)', Australian Journal of Primary Health, vol. 27, pp. 416 - 424, http://dx.doi.org/10.1071/PY20270

Journal articles | 2021

Cunio CB; Uster DW; Carland JE; Buscher H; Liu Z; Brett J; Stefani M; Jones GRD; Day RO; Wicha SG; Stocker SL, 2021, 'Towards precision dosing of vancomycin in critically ill patients: an evaluation of the predictive performance of pharmacometric models in ICU patients', Clinical Microbiology and Infection, vol. 27, pp. 783.e7 - 783.e14, http://dx.doi.org/10.1016/j.cmi.2020.07.005

Journal articles | 2021

Schaffer AL; Busingye D; Chidwick K; Brett J; Blogg S, 2021, 'Pregabalin prescribing patterns in Australian general practice, 2012–2018: a cross-sectional study', BJGP Open, vol. 5, pp. 1 - 10, http://dx.doi.org/10.3399/bjgpopen20X101120

Journal articles | 2021

Stocker SL; Carland JE; Reuter SE; Stacy AE; Schaffer AL; Stefani M; Lau C; Kirubakaran R; Yang JJ; Shen CFJ; Roberts DM; Marriott DJE; Day RO; Brett J, 2021, 'Evaluation of a Pilot Vancomycin Precision Dosing Advisory Service on Target Exposure Attainment Using an Interrupted Time Series Analysis', Clinical Pharmacology and Therapeutics, vol. 109, pp. 212 - 221, http://dx.doi.org/10.1002/cpt.2113

Journal articles | 2021

Uster DW; Stocker SL; Carland JE; Brett J; Marriott DJE; Day RO; Wicha SG, 2021, 'A Model Averaging/Selection Approach Improves the Predictive Performance of Model-Informed Precision Dosing: Vancomycin as a Case Study', Clinical Pharmacology and Therapeutics, vol. 109, pp. 175 - 183, http://dx.doi.org/10.1002/cpt.2065

Journal articles | 2020

Black E; Govindasamy L; Auld R; McArdle K; Sharpe C; Dawson A; Vazquez S; Brett J; Friend C; Shaw V; Tyner S; McDonald C; Koop D; Tall G; Welsby D; Habig K; Madeddu D; Cretikos M, 2020, 'Toxicological analysis of serious drug-related harm among electronic dance music festival attendees in New South Wales, Australia: A consecutive case series', Drug and Alcohol Dependence, vol. 213, pp. 108070, http://dx.doi.org/10.1016/j.drugalcdep.2020.108070

Journal articles | 2020

Brett J; Wylie C; Brown J, 2020, 'A case of significant hypotension following a human ingestion of veterinary pimobendan', Clinical Toxicology, vol. 58, pp. 146 - 148, http://dx.doi.org/10.1080/15563650.2019.1613550

Journal articles | 2020

Chiu T; Brett J; Pearson S; Schaffer A, 2020, 'Patterns of pregabalin initiation and discontinuation after its subsidy in Australia', British Journal of Clinical Pharmacology, http://dx.doi.org/10.1111/bcp.14276

Journal articles | 2020

Coleman L; Brett J; Daniels B; Pearson S; Falster M, 2020, 'Medicine reviews: do they reduce benzodiazepine use in older Australians?', Public Health Research & Practice, http://dx.doi.org/10.17061/phrp30452015

Journal articles | 2020

Gisev N; Brett J; Peacock A, 2020, 'Extra-medical use of antipsychotics: what can be learnt from experiences with other prescription medicines?', Addiction, vol. 115, pp. 1203 - 1205, http://dx.doi.org/10.1111/add.14823

Journal articles | 2020

Stefani M; Roberts DM; Brett J, 2020, 'High-dose insulin euglycemic therapy to treat cardiomyopathy associated with massive venlafaxine overdose', Clinical Toxicology, vol. 58, pp. 299 - 300, http://dx.doi.org/10.1080/15563650.2019.1638930

Journal articles | 2020

Wylie CE; Daniels B; Brett J; Pearson SA; Buckley NA, 2020, 'A national study on prescribed medicine use in Australia on a typical day', Pharmacoepidemiology and Drug Safety, vol. 29, pp. 1046 - 1053, http://dx.doi.org/10.1002/pds.5093

Journal articles | 2020

Zheng D; Brett J; Daniels B; Buckley NA; Pearson SA; Schaffer AL, 2020, 'Potentially inappropriate benzodiazepine use in Australian adults: A population-based study (2014–2017)', Drug and Alcohol Review, vol. 39, pp. 575 - 582, http://dx.doi.org/10.1111/dar.13086

Journal articles | 2019

Brett J; Wylie C; Raubenheimer J; Isbister G; Buckley N, 2019, 'The relative lethal toxicity of pharmaceutical and illicit substances; A 16-year study of the Greater Newcastle Hunter Area, Australia', British journal of clinical

Journal articles | 2019

Chalmers K; Badgery-Parker T; Pearson SA; Brett J; Scott I; Elshaug AG, 2019, 'Measuring 21 low-value health care procedures in Australian private health insurance claims data (2010 – 2014)', BMJ

Journal articles | 2018

Badgery-Parker T; Pearson SA; Chalmers K; Brett J; Scott IA; Dunn S; Onley N; Elshaug AG, 2018, 'Low-value care in Australian public hospitals: Prevalence and trends over time', BMJ Quality and Safety, vol. 28, pp. 205 - 214, http://dx.doi.org/10.1136/bmjqs-2018-008338

Journal articles | 2018

Brett J; Maust DT; Bouck Z; Ignacio RV; Mecredy G; Kerr EA; Bhatia S; Elshaug AG; Pearson SA, 2018, 'Benzodiazepine Use in Older Adults in the United States, Ontario, and Australia from 2010 to 2016', Journal of the American Geriatrics Society, vol. 66, pp. 1180 - 1185, http://dx.doi.org/10.1111/jgs.15292

Journal articles | 2018

Brett J; Schaffer A; Dobbins T; Buckley NA; Pearson SA, 2018, 'The impact of permissive and restrictive pharmaceutical policies on quetiapine dispensing: Evaluating a policy pendulum using interrupted time series analysis', Pharmacoepidemiology and Drug Safety, vol. 27, pp. 439 - 446, http://dx.doi.org/10.1002/pds.4408

Journal articles | 2018

Brett J; Zoega H; Buckley NA; Daniels BJ; Elshaug AG; Pearson SA, 2018, 'Choosing wisely? Quantifying the extent of three low value psychotropic prescribing practices in Australia', BMC Health Services Research, vol. 18, pp. 1009, http://dx.doi.org/10.1186/s12913-018-3811-5

Journal articles | 2018

Chalmers K; Badgery-Parker T; Pearson SA; Brett J; Scott IA; Elshaug AG, 2018, 'Developing indicators for measuring low-value care: Mapping Choosing Wisely recommendations to hospital data', BMC Research Notes, vol. 11, http://dx.doi.org/10.1186/s13104-018-3270-4

Journal articles | 2018

Karanges EA; Buckley NA; Brett J; Blanch B; Litchfield M; Degenhardt L; Pearson SA, 2018, 'Trends in opioid utilisation in Australia, 2006-2015: Insights from multiple metrics', Pharmacoepidemiology and Drug Safety, vol. 27, pp. 504 - 512, http://dx.doi.org/10.1002/pds.4369

Journal articles | 2017

Brett J; Daniels B; Karanges EA; Buckley NA; Schneider C; Nassir A; McLachlan AJ; Pearson SA, 2017, 'Psychotropic polypharmacy in Australia, 2006 to 2015: a descriptive cohort study', British Journal of Clinical Pharmacology, vol. 83, pp. 2581 - 2588, http://dx.doi.org/10.1111/bcp.13369

Journal articles | 2017

Brett J; Dawson A; Ivers R; Lawrence L; Barclay S; Conigrave K, 2017, 'Healing at home: Developing a model for ambulatory alcohol "detox" in an Aboriginal community controlled health service', International Journal of Indigenous Health, vol. 12, pp. 24 - 38, http://dx.doi.org/10.18357/ijih121201716906

Journal articles | 2017

Brett J; Elshaug AG; Bhatia RS; Chalmers K; Badgery-Parker T; Pearson SA, 2017, 'A methodological protocol for selecting and quantifying low-value prescribing practices in routinely collected data: An Australian case study', Implementation Science, vol. 12, http://dx.doi.org/10.1186/s13012-017-0585-9

Journal articles | 2017

Brett J; Karanges EA; Daniels B; Buckley NA; Schneider C; Nassir A; Zoega H; McLachlan AJ; Pearson SA, 2017, 'Psychotropic medication use in Australia, 2007 to 2015: Changes in annual incidence, prevalence and treatment exposure', Australian and New Zealand Journal of Psychiatry, vol. 51, pp. 990 - 999, http://dx.doi.org/10.1177/0004867417721018

Journal articles | 2015

Brett J, 2015, 'Concerns about quetiapine', Australian Prescriber, vol. 38, pp. 95 - 97, http://dx.doi.org/10.18773/austprescr.2015.032

Journal articles | 2015

Brett J; Murnion B, 2015, 'Management of benzodiazepine misuse and dependence', Australian Prescriber, vol. 38, pp. 152 - 155, http://dx.doi.org/10.18773/austprescr.2015.055

Journal articles | 2015

Brett J; Murnion B, 2015, 'Pregabalin to treat ciguatera fish poisoning', Clinical Toxicology, vol. 53, pp. 588, http://dx.doi.org/10.3109/15563650.2015.1052499

Journal articles | 2015

Montebello ME; Brett B, 2015, 'Misuse and associated harms of quetiapine and other atypical antipsychotics', Current Topics in Behavioral Neurosciences, vol. 34, pp. 1 - 15, http://dx.doi.org/10.1007/7854_2015_424

Journal articles | 2014

Brett J; Dawson AH; Brown JA, 2014, 'Clenbuterol toxicity: A NSW Poisons Information Centre experience', Medical Journal of Australia, vol. 200, pp. 219 - 221, http://dx.doi.org/10.5694/mja13.10982

Journal articles | 2013

Baysari M; Brett J; Lam V; Milder T; Killen L; Chau AMT; McMullan B; Harkness J; Marriot D; Day R, 2013, 'Pneumonia Severity Scores and Prescribing Antibiotics for Community-Acquired Pneumonia at an Australian Hospital', Journal of Pharmacy Practice and Research, vol. 43, pp. 97 - 101, http://dx.doi.org/10.1002/j.2055-2335.2013.tb00228.x

Journal articles | 2013

Brett J; Chong O; Graham GG; Ray J; Marriott D; Williams KM; Day RO, 2013, 'Antifungal Use and Therapeutic Monitoring of Plasma Concentrations of Itraconazole in Heart and Lung Transplantation Patients.', Therapeutic Drug Monitoring, vol. 35, pp. 133 - 136, http://dx.doi.org/10.1097/FTD.0b013e318275fe69

Journal articles | 2013

Wong C; Kumar SS; Graham GG; Begg EJ; Chin P; Brett J; Ray J; Marriott D; Williams KM; Day RO, 2013, 'Comparing dose prediction software used to manage gentamicin dosing', Internal Medicine Journal, vol. 43, pp. 519 - 525, http://dx.doi.org/10.1111/imj.12067

Journal articles | 2011

Lipworth WL; Kerridge IH; Brett J; Day RO, 2011, 'How clinical and resaerch failures lead to suboptimal prescribing: the example of chronic gout', British Medical Journal, vol. 343, pp. 1 - 3, http://dx.doi.org/10.1136/bmj.d7459
Conference Abstracts | 2022

Schaffer AL; Brett J; Buckley NA; Pearson SA, 2022, 'Trajectories of pregabalin use and their association with longitudinal changes in opioid and benzodiazepine use', in Pain, LIPPINCOTT WILLIAMS & WILKINS, United States, Vol. 163, pp. E614 - E621, United States, http://dx.doi.org/10.1097/j.pain.0000000000002433

Conference Presentations | 2021

Page RMS; Healey A; Siefried K; Harrod M; Franklin E; Barratt M; Peacock A; Brett J, 2021, 'Barriers to seeking help among music festival attendees in New South Wales, Australia', presented at The APSAD Scientific Drug and Alcohol Conference, Virtual, 07 November 2021 - 10 November 2021, http://dx.doi.org/10.1111/dar.13384

Reports | 2013

Lukins TR; Pett SL; Brett J, 2013, Is it worth the weight?

NHMRC Investigator Grant: Opioid safety in pregnancy

IHIF Grant: Pharmacogenomics in mental health

IHIF Grant: Take home naloxone in Emergency Departments

Gustav Nossal Award for top ranking NH&MRC Clinical Research Postgraduate Scholarship applicant nationally – 2015.
NSW Aboriginal Health Award for integrated planning and service delivery – 2014.
Aboriginal Drug and Alcohol Network (AH&MRC) project of the year award – 2014.
Registrar of the year award: St. Vincent’s Hospital, Sydney - 2012
Final Year Medal – Goyder Scholarship for Clinical Excellence in Medicine and Surgery- 2005

Pharmacoepidemiology: Opioid and psychotropics quality and safety of prescribing and safety in pregnancy

Psychedelic-assisted psychotherapy and micro-dosing: Methamphetamine use disorder, depression

Drugs of abuse, drug overdose response and prevention

Toxicoepidemiology: The relative toxicity of drugs taken in overdose

Pharmacogenomics: The role of pharmacogenomics in mental health

Therapeutic Drug Monitoring: The implementation of a TDM service at St. Vincent's Hospital, antimicrobial TDM, tacrolimus toxicity in transplant medicine.

My Research Supervision

Honors x2

PhD x2

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Dr Jonathan Brett