Professor

Professor Joseph Powell

Medicine & Health
School of Biomedical Sciences
  • Journal articles | 2022
    Chin V; Arora H; Senabouth A; Hernandez JA; McCloy R; Simes J; Boyer M; Hogg P; Young J; Joshua A; Brown B; Watkins N; Powell J, 2022, 'EP16.03-041 Single Cell RNA Sequencing Reveals Phenotypic Predispositions to Developing Lung Cancer in Never-Smokers', Journal of Thoracic Oncology, vol. 17, pp. S608 - S608, http://dx.doi.org/10.1016/j.jtho.2022.07.1102
    Journal articles | 2022
    Daniszewski M; Senabouth A; Liang HH; Han X; Lidgerwood GE; Hernández D; Sivakumaran P; Clarke JE; Lim SY; Lees JG; Rooney L; Gulluyan L; Souzeau E; Graham SL; Chan C-L; Nguyen U; Farbehi N; Gnanasambandapillai V; McCloy RA; Clarke L; Kearns LS; Mackey DA; Craig JE; MacGregor S; Powell JE; Pébay A; Hewitt AW, 2022, 'Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma', Cell Genomics, vol. 2, pp. 100142 - 100142, http://dx.doi.org/10.1016/j.xgen.2022.100142
    Journal articles | 2022
    Patel B; Kleeman SO; Neavin D; Powell J; Baskozos G; Ng M; Ahmed WUR; Bennett DL; Schmid AB; Furniss D; Wiberg A, 2022, 'Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study', The Lancet Rheumatology, vol. 4, pp. e556 - e565, http://dx.doi.org/10.1016/S2665-9913(22)00180-1
    Journal articles | 2022
    Phipson B; Sim CB; Porrello ER; Hewitt AW; Powell J; Oshlack A, 2022, 'propeller: testing for differences in cell type proportions in single cell data', Bioinformatics (Oxford, England), vol. 38, pp. 4720 - 4726, http://dx.doi.org/10.1093/bioinformatics/btac582
    Journal articles | 2022
    Senabouth A; Daniszewski M; Lidgerwood GE; Liang HH; Hernández D; Mirzaei M; Keenan SN; Zhang R; Han X; Neavin D; Rooney L; Lopez Sanchez MIG; Gulluyan L; Paulo JA; Clarke L; Kearns LS; Gnanasambandapillai V; Chan CL; Nguyen U; Steinmann AM; McCloy RA; Farbehi N; Gupta VK; Mackey DA; Bylsma G; Verma N; MacGregor S; Watt MJ; Guymer RH; Powell JE; Hewitt AW; Pébay A, 2022, 'Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration', Nature Communications, vol. 13, http://dx.doi.org/10.1038/s41467-022-31707-4
    Journal articles | 2022
    Talenti A; Powell J; Hemmink JD; Cook EAJ; Wragg D; Jayaraman S; Paxton E; Ezeasor C; Obishakin ET; Agusi ER; Tijjani A; Amanyire W; Muhanguzi D; Marshall K; Fisch A; Ferreira BR; Qasim A; Chaudhry U; Wiener P; Toye P; Morrison LJ; Connelley T; Prendergast JGD, 2022, 'A cattle graph genome incorporating global breed diversity.', Nat Commun, vol. 13, pp. 910, http://dx.doi.org/10.1038/s41467-022-28605-0
    Journal articles | 2022
    Wilson SB; Howden SE; Vanslambrouck JM; Dorison A; Alquicira-Hernandez J; Powell JE; Little MH, 2022, 'DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets', Genome Medicine, vol. 14, http://dx.doi.org/10.1186/s13073-022-01023-z
    Journal articles | 2022
    Yazar S; Alquicira-Hernandez J; Wing K; Senabouth A; Gordon MG; Andersen S; Lu Q; Rowson A; Taylor TRP; Clarke L; Maccora K; Chen C; Cook AL; Ye CJ; Fairfax KA; Hewitt AW; Powell JE, 2022, 'Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease', Science, vol. 376, http://dx.doi.org/10.1126/science.abf3041
    Journal articles | 2022
    Yazar S; Powell JE, 2022, 'Single-cell expression Quantitative Trait Loci: T-cell immunology teams up with statistical genetics', Immunology and Cell Biology, vol. 100, pp. 588 - 590, http://dx.doi.org/10.1111/imcb.12577
    Journal articles | 2022
    Zammit NW; McDowell J; Warren J; Muskovic W; Gamble J; Shi YC; Kaczorowski D; Chan CL; Powell J; Ormandy C; Brown D; Oakes SR; Grey ST, 2022, 'TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation', Frontiers in Immunology, vol. 13, http://dx.doi.org/10.3389/fimmu.2022.811525
    Journal articles | 2021
    Alquicira-Hernandez J; Powell JE, 2021, 'Nebulosa recovers single-cell gene expression signals by kernel density estimation', Bioinformatics, vol. 37, pp. 2485 - 2487, http://dx.doi.org/10.1093/bioinformatics/btab003
    Journal articles | 2021
    Alquicira-Hernandez J; Powell JE; Phan TG, 2021, 'No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease', Clinical and Translational Immunology, vol. 10, pp. e1308, http://dx.doi.org/10.1002/cti2.1308
    Journal articles | 2021
    Bui LT; Winters NI; Chung M-I; Joseph C; Gutierrez AJ; Habermann AC; Adams TS; Schupp JC; Poli S; Peter LM; Taylor CJ; Blackburn JB; Richmond BW; Nicholson AG; Rassl D; Wallace WA; Rosas IO; Jenkins RG; Kaminski N; Kropski JA; Banovich NE; Human Cell Atlas Lung Biological Network , 2021, 'Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.', Nat Commun, vol. 12, pp. 4314, http://dx.doi.org/10.1038/s41467-021-24467-0
    Journal articles | 2021
    Chin V; Stone E; Havryk A; Plit M; Mccloy R; Murphy A; Field A; Watkins N; Powell J, 2021, 'P60.01 Single-Cell Transcriptomics to Assess Response to Immunotherapy in Advanced Lung Cancer ex-vivo: Developing a Functional Predictive Assay', Journal of Thoracic Oncology, vol. 16, pp. S540 - S541, http://dx.doi.org/10.1016/j.jtho.2021.01.960
    Journal articles | 2021
    Cohen J; Blumenthal A; Cuellar-Partida G; Evans DM; Finfer S; Li Q; Ljungberg J; Myburgh J; Peach E; Powell J; Rajbhandari D; Rhodes A; Senabouth A; Venkatesh B, 2021, 'The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock', Intensive Care Medicine, vol. 47, pp. 974 - 983, http://dx.doi.org/10.1007/s00134-021-06464-5
    Journal articles | 2021
    Currant H; Hysi P; Fitzgerald TW; Gharahkhani P; Bonnemaijer PWM; Senabouth A; Hewitt AW; Atan D; Aung T; Charng J; Choquet H; Craig J; Khaw PT; Klaver CCW; Kubo M; Ong JS; Pasquale LR; Reisman CA; Daniszewski M; Powell JE; Pébay A; Simcoe MJ; Thiadens AAHJ; van Duijn CM; Yazar S; Jorgenson E; MacGregor S; Hammond CJ; Mackey DA; Wiggs JL; Foster PJ; Patel PJ; Birney E; Khawaja AP, 2021, 'Erratum: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images (PLoS Genet (2021) 17:5 (e1009497) DOI: 10.1371/journal.pgen.1009497)', PLoS Genetics, vol. 17, http://dx.doi.org/10.1371/journal.pgen.1009858
    Journal articles | 2021
    Currant H; Hysi P; Fitzgerald TW; Gharahkhani P; Bonnemaijer PWM; Senabouth A; Hewitt AW; Atan D; Aung T; Charng J; Choquet H; Craig J; Khaw PT; Klaver CCW; Kubo M; Ong JS; Pasquale LR; Reisman CA; Daniszewski M; Powell JE; Pébay A; Simcoe MJ; Thiadens AAHJ; van Duijn CM; Yazar S; Jorgenson E; MacGregor S; Hammond CJ; Mackey DA; Wiggs JL; Foster PJ; Patel PJ; Birney E; Khawaja AP, 2021, 'Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images', PLoS Genetics, vol. 17, http://dx.doi.org/10.1371/journal.pgen.1009497
    Journal articles | 2021
    Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, vol. 36, http://dx.doi.org/10.1016/j.celrep.2021.109722
    Journal articles | 2021
    Hemani G; Powell JE; Wang H; Shakhbazov K; Westra HJ; Esko T; Henders AK; McRae AF; Martin NG; Metspalu A; Franke L; Montgomery GW; Goddard ME; Gibson G; Yang J; Visscher PM, 2021, 'Phantom epistasis between unlinked loci', Nature, vol. 596, pp. E1 - E3, http://dx.doi.org/10.1038/s41586-021-03765-z
    Journal articles | 2021
    Hemani G; Shakhbazov K; Westra HJ; Esko T; Henders AK; McRae AF; Yang J; Gibson G; Martin NG; Metspalu A; Franke L; Montgomery GW; Visscher PM; Powell JE, 2021, 'Retraction Note: Detection and replication of epistasis influencing transcription in humans (Nature, (2014), 508, 7495, (249-253), 10.1038/nature13005)', Nature, vol. 596, pp. 306, http://dx.doi.org/10.1038/s41586-021-03766-y
    Journal articles | 2021
    Lidgerwood GE; Senabouth A; Smith-Anttila CJA; Gnanasambandapillai V; Kaczorowski DC; Amann-Zalcenstein D; Fletcher EL; Naik SH; Hewitt AW; Powell JE; Pébay A, 2021, 'Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time', Genomics, Proteomics and Bioinformatics, vol. 19, pp. 223 - 242, http://dx.doi.org/10.1016/j.gpb.2020.08.002
    Journal articles | 2021
    Mills MC; Tropf FC; Brazel DM; van Zuydam N; Vaez A; Agbessi M; Ahsan H; Alves I; Andiappan AK; Arindrarto W; Awadalla P; Battle A; Beutner F; Jan Bonder M; Boomsma DI; Christiansen MW; Claringbould A; Deelen P; Esko T; Favé MJ; Franke L; Frayling T; Gharib SA; Gibson G; Heijmans BT; Hemani G; Jansen R; Kähönen M; Kalnapenkis A; Kasela S; Kettunen J; Kim Y; Kirsten H; Kovacs P; Krohn K; Kronberg J; Kukushkina V; Kutalik Z; Lee B; Lehtimäki T; Loeffler M; Marigorta UM; Mei H; Milani L; Montgomery GW; Müller-Nurasyid M; Nauck M; Nivard MG; Penninx BWJH; Perola M; Pervjakova N; Pierce BL; Powell J; Prokisch H; Psaty BM; Raitakari OT; Ripatti S; Rotzschke O; Rüeger S; Saha A; Scholz M; Schramm K; Seppälä I; Slagboom EP; Stehouwer CDA; Stumvoll M; Sullivan P; ‘t Hoen PAC; Teumer A; Thiery J; Tong L; Tönjes A; van Dongen J; van Iterson M; van Meurs J; Veldink JH; Verlouw J; Visscher PM; Völker U; Võsa U; Westra HJ; Wijmenga C; Yaghootkar H; Yang J; Zeng B; Zhang F; van Greevenbroek MMJ; Schalkwijk CG; Deelen J; van Heemst D; van Duijn CM; Hofman BA; Isaacs A; Uitterlinden AG; Verbiest M; Suchiman HED; Verkerk M; van der Breggen R; van Rooij J; Lakenberg N, 2021, 'Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour', Nature Human Behaviour, http://dx.doi.org/10.1038/s41562-021-01135-3
    Journal articles | 2021
    Muskovic W; Powell JE, 2021, 'DropletQC: improved identification of empty droplets and damaged cells in single-cell RNA-seq data', Genome Biology, vol. 22, http://dx.doi.org/10.1186/s13059-021-02547-0
    Journal articles | 2021
    Muus C; Luecken MD; Eraslan G; Sikkema L; Waghray A; Heimberg G; Kobayashi Y; Vaishnav ED; Subramanian A; Smillie C; Jagadeesh KA; Duong ET; Fiskin E; Triglia ET; Ansari M; Cai P; Lin B; Buchanan J; Chen S; Shu J; Haber AL; Chung H; Montoro DT; Adams T; Aliee H; Allon SJ; Andrusivova Z; Angelidis I; Ashenberg O; Bassler K; Bécavin C; Benhar I; Bergenstråhle J; Bergenstråhle L; Bolt L; Braun E; Bui LT; Callori S; Chaffin M; Chichelnitskiy E; Chiou J; Conlon TM; Cuoco MS; Cuomo ASE; Deprez M; Duclos G; Fine D; Fischer DS; Ghazanfar S; Gillich A; Giotti B; Gould J; Guo M; Gutierrez AJ; Habermann AC; Harvey T; He P; Hou X; Hu L; Hu Y; Jaiswal A; Ji L; Jiang P; Kapellos TS; Kuo CS; Larsson L; Leney-Greene MA; Lim K; Litviňuková M; Ludwig LS; Lukassen S; Luo W; Maatz H; Madissoon E; Mamanova L; Manakongtreecheep K; Leroy S; Mayr CH; Mbano IM; McAdams AM; Nabhan AN; Nyquist SK; Penland L; Poirion OB; Poli S; Qi CC; Queen R; Reichart D; Rosas I; Schupp JC; Shea CV; Shi X; Sinha R; Sit RV; Slowikowski K; Slyper M; Smith NP; Sountoulidis A; Strunz M; Sullivan TB, 2021, 'Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics', Nature Medicine, vol. 27, pp. 546 - 559, http://dx.doi.org/10.1038/s41591-020-01227-z
    Journal articles | 2021
    Neavin D; Nguyen Q; Daniszewski MS; Liang HH; Chiu HS; Wee YK; Senabouth A; Lukowski SW; Crombie DE; Lidgerwood GE; Hernández D; Vickers JC; Cook AL; Palpant NJ; Pébay A; Hewitt AW; Powell JE, 2021, 'Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells', Genome Biology, vol. 22, http://dx.doi.org/10.1186/s13059-021-02293-3
    Journal articles | 2021
    Nieto P; Elosua-Bayes M; Trincado JL; Marchese D; Massoni-Badosa R; Salvany M; Henriques A; Nieto J; Aguilar-Fernández S; Mereu E; Moutinho C; Ruiz S; Lorden P; Chin VT; Kaczorowski D; Chan CL; Gallagher R; Chou A; Planas-Rigol E; Rubio-Perez C; Gut I; Piulats JM; Seoane J; Powell JE; Batlle E; Heyn H, 2021, 'A single-cell tumor immune atlas for precision oncology', Genome Research, vol. 31, pp. 1913 - 1926, http://dx.doi.org/10.1101/gr.273300.120
    Journal articles | 2021
    Shen S; Sun Y; Matsumoto M; Shim WJ; Sinniah E; Wilson SB; Werner T; Wu Z; Bradford ST; Hudson J; Little MH; Powell J; Nguyen Q; Palpant NJ, 2021, 'Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation', Trends in Molecular Medicine, vol. 27, pp. 1135 - 1158, http://dx.doi.org/10.1016/j.molmed.2021.09.006
    Journal articles | 2021
    Sinclair KA; Yerkovich ST; Hopkins PMA; Fieuw AM; Ford P; Powell JE; O'Sullivan B; Chambers DC, 2021, 'The autotaxin-lysophosphatidic acid pathway mediates mesenchymal cell recruitment and fibrotic contraction in lung transplant fibrosis', Journal of Heart and Lung Transplantation, vol. 40, pp. 12 - 23, http://dx.doi.org/10.1016/j.healun.2020.10.005
    Journal articles | 2021
    Thompson M; Matsumoto M; Ma T; Senabouth A; Palpant NJ; Powell JE; Nguyen Q, 2021, 'scGPS: Determining Cell States and Global Fate Potential of Subpopulations', Frontiers in Genetics, vol. 12, http://dx.doi.org/10.3389/fgene.2021.666771
    Journal articles | 2021
    Tuong ZK; Lukowski SW; Nguyen QH; Chandra J; Zhou C; Gillinder K; Bashaw AA; Ferdinand JR; Stewart BJ; Teoh SM; Hanson SJ; Devitt K; Clatworthy MR; Powell JE; Frazer IH, 2021, 'A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia', iScience, vol. 24, pp. 103326 - 103326, http://dx.doi.org/10.1016/j.isci.2021.103326
    Journal articles | 2021
    Võsa U; Claringbould A; Westra HJ; Bonder MJ; Deelen P; Zeng B; Kirsten H; Saha A; Kreuzhuber R; Yazar S; Brugge H; Oelen R; de Vries DH; van der Wijst MGP; Kasela S; Pervjakova N; Alves I; Favé MJ; Agbessi M; Christiansen MW; Jansen R; Seppälä I; Tong L; Teumer A; Schramm K; Hemani G; Verlouw J; Yaghootkar H; Sönmez Flitman R; Brown A; Kukushkina V; Kalnapenkis A; Rüeger S; Porcu E; Kronberg J; Kettunen J; Lee B; Zhang F; Qi T; Hernandez JA; Arindrarto W; Beutner F; Dmitrieva J; Elansary M; Fairfax BP; Georges M; Heijmans BT; Hewitt AW; Kähönen M; Kim Y; Knight JC; Kovacs P; Krohn K; Li S; Loeffler M; Marigorta UM; Mei H; Momozawa Y; Müller-Nurasyid M; Nauck M; Nivard MG; Penninx BWJH; Pritchard JK; Raitakari OT; Rotzschke O; Slagboom EP; Stehouwer CDA; Stumvoll M; Sullivan P; 't Hoen PAC; Thiery J; Tönjes A; van Dongen J; van Iterson M; Veldink JH; Völker U; Warmerdam R; Wijmenga C; Swertz M; Andiappan A; Montgomery GW; Ripatti S; Perola M; Kutalik Z; Dermitzakis E; Bergmann S; Frayling T; van Meurs J; Prokisch H; Ahsan H; Pierce BL; Lehtimäki T; Boomsma DI; Psaty BM; Gharib SA; Awadalla P; Milani L; Ouwehand WH; Downes K; Stegle O, 2021, 'Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression', Nature genetics, vol. 53, pp. 1300 - 1310, http://dx.doi.org/10.1038/s41588-021-00913-z
    Journal articles | 2021
    Wu SZ; Al-Eryani G; Roden DL; Junankar S; Harvey K; Andersson A; Thennavan A; Wang C; Torpy JR; Bartonicek N; Wang T; Larsson L; Kaczorowski D; Weisenfeld NI; Uytingco CR; Chew JG; Bent ZW; Chan CL; Gnanasambandapillai V; Dutertre CA; Gluch L; Hui MN; Beith J; Parker A; Robbins E; Segara D; Cooper C; Mak C; Chan B; Warrier S; Ginhoux F; Millar E; Powell JE; Williams SR; Liu XS; O’Toole S; Lim E; Lundeberg J; Perou CM; Swarbrick A, 2021, 'A single-cell and spatially resolved atlas of human breast cancers', Nature Genetics, vol. 53, pp. 1334 - 1347, http://dx.doi.org/10.1038/s41588-021-00911-1
    Journal articles | 2021
    Wu SZ; Roden DL; Al-Eryani G; Bartonicek N; Harvey K; Cazet AS; Chan CL; Junankar S; Hui MN; Millar EA; Beretov J; Horvath L; Joshua AM; Stricker P; Wilmott JS; Quek C; Long GV; Scolyer RA; Yeung BZ; Segara D; Mak C; Warrier S; Powell JE; O’Toole S; Lim E; Swarbrick A, 2021, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', Genome Medicine, vol. 13, pp. 81, http://dx.doi.org/10.1186/s13073-021-00885-z
    Journal articles | 2020
    Avila Cobos F; Alquicira-Hernandez J; Powell JE; Mestdagh P; De Preter K, 2020, 'Benchmarking of cell type deconvolution pipelines for transcriptomics data', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-19015-1
    Journal articles | 2020
    Byrne AJ; Powell JE; O’Sullivan BJ; Ogger PP; Hoffland A; Cook J; Bonner KL; Hewitt RJ; Wolf S; Ghai P; Walker SA; Lukowski SW; Molyneaux PL; Saglani S; Chambers DC; Maher TM; Lloyd CM, 2020, 'Dynamics of human monocytes and airway macrophages during healthy aging and after transplant', Journal of Experimental Medicine, vol. 217, http://dx.doi.org/10.1084/jem.20191236
    Journal articles | 2020
    Cobos FA; Alquicira-Hernandez J; Powell JE; Mestdagh P; De Preter K, 2020, 'Author Correction: Benchmarking of cell type deconvolution pipelines for transcriptomics data (Nature Communications, (2020), 11, 1, (5650), 10.1038/s41467-020-19015-1)', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-20288-9
    Journal articles | 2020
    D'Urso S; Rajbhandari D; Peach E; De Guzman E; Li Q; Medland SE; Gordon SD; Martin NG; Ligthart S; Brown MA; Powell J; McArthur C; Rhodes A; Meyer J; Finfer S; Myburgh J; Blumenthal A; Cohen J; Venkatesh B; Cuellar-Partida G; Evans DM, 2020, 'Septic Shock: A Genomewide Association Study and Polygenic Risk Score Analysis', Twin Research and Human Genetics, vol. 23, pp. 204 - 213, http://dx.doi.org/10.1017/thg.2020.60
    Journal articles | 2020
    Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell E; Nair SS; Zotenko E; Gould CM; Buckley M; Kaczorowski D; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2020, 'DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity', , http://dx.doi.org/10.1101/2020.10.15.338855
    Journal articles | 2020
    Engel JA; Lee HJ; Williams CG; Kuns R; Olver S; Lansink LIM; Soon MSF; Andersen SB; Powell JE; Svensson V; Teichmann SA; Hill GR; Varelias A; Koyama M; Haque A, 2020, 'Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease', JCI Insight, vol. 5, http://dx.doi.org/10.1172/jci.insight.137990
    Journal articles | 2020
    Hammerschlag AR; Byrne EM; Agbessi M; Ahsan H; Alves I; Andiappan A; Arindrarto W; Awadalla P; Battle A; Beutner F; Bonder MJ; Boomsma DI; Christiansen M; Claringbould A; Deelen P; Esko T; Favé MJ; Franke L; Frayling T; Gharib SA; Gibson G; Heijmans BT; Hemani G; Jansen R; Kähönen M; Kalnapenkis A; Kasela S; Kettunen J; Kim Y; Kirsten H; Kovacs P; Krohn K; Kronberg-Guzman J; Kukushkina V; Kutalik Z; Lee B; Lehtimäki T; Loeffler M; Marigorta UM; Mei H; Milani L; Montgomery GW; Müller-Nurasyid M; Nauck M; Nivard M; Penninx B; Perola M; Pervjakova N; Pierce BL; Powell J; Prokisch H; Psaty BM; Raitakari OT; Ripatti S; Rotzschke O; Rüeger S; Saha A; Scholz M; Schramm K; Seppälä I; Slagboom EP; Stehouwer CDA; Stumvoll M; Sullivan P; ‘t Hoen PAC; Teumer A; Thiery J; Tong L; Tönjes A; van Dongen J; van Iterson M; van Meurs J; Veldink JH; Verlouw J; Visscher PM; Völker U; Võsa U; Westra HJ; Wijmenga C; Yaghootkar H; Yang J; Zeng B; Zhang F; Isaacs A; Pool R; Hottenga JJ; van Greevenbroek MM; van der Kallen CJH; Schalkwijk CG; Zhernakova S; Tigchelaar EF; Slagboom PE; Beekman M; Deelen J; van Heemst D; van den Berg LH; van Duijn CM; Hofman BA; Uitterlinden AG; Jhamai PM, 2020, 'Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies', Biological Psychiatry, vol. 88, pp. 470 - 479, http://dx.doi.org/10.1016/j.biopsych.2020.05.002
    Journal articles | 2020
    Kott KA; Vernon ST; Hansen T; de Dreu M; Das SK; Powell J; de St Groth BF; Di Bartolo BA; McGuire HM; Figtree GA, 2020, 'Single-cell immune profiling in coronary artery disease: The role of state-of-the-art immunophenotyping with mass cytometry in the diagnosis of atherosclerosis', Journal of the American Heart Association, vol. 9, pp. e017759, http://dx.doi.org/10.1161/JAHA.120.017759
    Journal articles | 2020
    Ogger PP; Albers GJ; Hewitt RJ; O’Sullivan BJ; Powell JE; Calamita E; Ghai P; Walker SA; McErlean P; Saunders P; Kingston S; Molyneaux PL; Halket JM; Gray R; Chambers DC; Maher TM; Lloyd CM; Byrne AJ, 2020, 'Itaconate controls the severity of pulmonary fibrosis', Science Immunology, vol. 5, http://dx.doi.org/10.1126/SCIIMMUNOL.ABC1884
    Journal articles | 2020
    Pinese M; Lacaze P; Rath EM; Stone A; Brion MJ; Ameur A; Nagpal S; Puttick C; Husson S; Degrave D; Cristina TN; Kahl VFS; Statham AL; Woods RL; McNeil JJ; Riaz M; Barr M; Nelson MR; Reid CM; Murray AM; Shah RC; Wolfe R; Atkins JR; Fitzsimmons C; Cairns HM; Green MJ; Carr VJ; Cowley MJ; Pickett HA; James PA; Powell JE; Kaplan W; Gibson G; Gyllensten U; Cairns MJ; McNamara M; Dinger ME; Thomas DM, 2020, 'The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-019-14079-0
    Journal articles | 2020
    Senabouth A; Andersen S; Shi Q; Shi L; Jiang F; Zhang W; Wing K; Daniszewski M; Lukowski SW; Hung SSC; Nguyen Q; Fink L; Beckhouse A; Pébay A; Hewitt AW; Powell JE, 2020, 'Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing', NAR Genomics and Bioinformatics, vol. 2, http://dx.doi.org/10.1093/nargab/lqaa034
    Journal articles | 2020
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    Tucker NR; Chaffin M; Bedi KC; Papangeli I; Akkad A-D; Arduini A; Hayat S; Eraslan G; Muus C; Bhattacharyya RP; Stegmann CM; Human Cell Atlas Lung Biological Network ; Margulies KB; Ellinor PT; Human Cell Atlas Lung Biological Network Consortium Members , 2020, 'Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis.', Circulation, vol. 142, pp. 708 - 710, http://dx.doi.org/10.1161/CIRCULATIONAHA.120.047911
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    Ziegler CGK; Allon SJ; Nyquist SK; Mbano IM; Miao VN; Tzouanas CN; Cao Y; Yousif AS; Bals J; Hauser BM; Feldman J; Muus C; Wadsworth MH; Kazer SW; Hughes TK; Doran B; Gatter GJ; Vukovic M; Taliaferro F; Mead BE; Guo Z; Wang JP; Gras D; Plaisant M; Ansari M; Angelidis I; Adler H; Sucre JMS; Taylor CJ; Lin B; Waghray A; Mitsialis V; Dwyer DF; Buchheit KM; Boyce JA; Barrett NA; Laidlaw TM; Carroll SL; Colonna L; Tkachev V; Peterson CW; Yu A; Zheng HB; Gideon HP; Winchell CG; Lin PL; Bingle CD; Snapper SB; Kropski JA; Theis FJ; Schiller HB; Zaragosi LE; Barbry P; Leslie A; Kiem HP; Flynn JAL; Fortune SM; Berger B; Finberg RW; Kean LS; Garber M; Schmidt AG; Lingwood D; Shalek AK; Ordovas-Montanes J; Banovich N; Brazma A; Desai T; Duong TE; Eickelberg O; Falk C; Farzan M; Glass I; Haniffa M; Horvath P; Hung D; Kaminski N; Krasnow M; Kuhnemund M; Lafyatis R; Lee H; Leroy S; Linnarson S; Lundeberg J; Meyer K; Misharin A; Nawijn M; Nikolic MZ; Pe'er D; Powell J; Quake S; Rajagopal J; Tata PR; Rawlins EL; Regev A; Reyfman PA; Rojas M; Rosen O; Saeb-Parsy K; Samakovlis C, 2020, 'SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues', Cell, vol. 181, pp. 1016 - 1035.e19, http://dx.doi.org/10.1016/j.cell.2020.04.035
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    van der Wijst MGP; de Vries DH; Groot HE; Trynka G; Hon CC; Bonder MJ; Stegle O; Nawijn MC; Idaghdour Y; van der Harst P; Ye CJ; Powell J; Theis FJ; Mahfouz A; Heinig M; Franke L, 2020, 'The single-cell eQTLGen consortium', eLife, vol. 9, http://dx.doi.org/10.7554/eLife.52155
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    Alquicira-Hernandez J; Sathe A; Ji HP; Nguyen Q; Powell JE, 2019, 'ScPred: Accurate supervised method for cell-type classification from single-cell RNA-seq data', Genome Biology, vol. 20, http://dx.doi.org/10.1186/s13059-019-1862-5
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    Chambers DC; Carew AM; Lukowski SW; Powell JE, 2019, 'Transcriptomics and single-cell RNA-sequencing', Respirology, vol. 24, pp. 29 - 36, http://dx.doi.org/10.1111/resp.13412
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    Karlsson Linnér R; Biroli P; Kong E; Meddens SFW; Wedow R; Fontana MA; Lebreton M; Tino SP; Abdellaoui A; Hammerschlag AR; Nivard MG; Okbay A; Rietveld CA; Timshel PN; Trzaskowski M; Vlaming RD; Zünd CL; Bao Y; Buzdugan L; Caplin AH; Chen CY; Eibich P; Fontanillas P; Gonzalez JR; Joshi PK; Karhunen V; Kleinman A; Levin RZ; Lill CM; Meddens GA; Muntané G; Sanchez-Roige S; Rooij FJV; Taskesen E; Wu Y; Zhang F; Agee M; Alipanahi B; Bell RK; Bryc K; Elson SL; Furlotte NA; Huber KE; Litterman NK; McCreight JC; McIntyre MH; Mountain JL; Northover CAM; Pitts SJ; Sathirapongsasuti JF; Sazonova OV; Shelton JF; Shringarpure S; Tian C; Tung JY; Vacic V; Wilson CH; Agbessi M; Ahsan H; Alves I; Andiappan A; Awadalla P; Battle A; Beutner F; Jan Bonder M; Boomsma DI; Christiansen M; Claringbould A; Deelen P; Esko T; Favé MJ; Franke L; Frayling T; Gharib SA; Gibson G; Heijmans B; Hemani G; Jansen R; Kähönen M; Kalnapenkis A; Kasela S; Kettunen J; Kim Y; Kirsten H; Kovacs P; Krohn K; Kronberg-Guzman J; Kukushkina V; Kutalik Z; Lee B; Lehtimäki T; Loeffler M; Marigorta UM; Metspalu A; Milani L; Montgomery GW; Müller-Nurasyid M; Nauck M; Penninx B; Perola M, 2019, 'Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences', Nature Genetics, vol. 51, pp. 245 - 257, http://dx.doi.org/10.1038/s41588-018-0309-3
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    Lukowski SW; Lo CY; Sharov AA; Nguyen Q; Fang L; Hung SSC; Zhu L; Zhang T; Grünert U; Nguyen T; Senabouth A; Jabbari JS; Welby E; Sowden JC; Waugh HS; Mackey A; Pollock G; Lamb TD; Wang PY; Hewitt AW; Gillies MC; Powell JE; Wong RCB, 2019, 'A single-cell transcriptome atlas of the adult human retina', EMBO Journal, vol. 38, pp. e100811, http://dx.doi.org/10.15252/embj.2018100811
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    Lukowski SW; Patel J; Andersen SB; Sim SL; Wong HY; Tay J; Winkler I; Powell JE; Khosrotehrani K, 2019, 'Single-Cell Transcriptional Profiling of Aortic Endothelium Identifies a Hierarchy from Endovascular Progenitors to Differentiated Cells', Cell Reports, vol. 27, pp. 2748 - 2758.e3, http://dx.doi.org/10.1016/j.celrep.2019.04.102
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    O'Sullivan B; Powell J; Lukowski S; Tan M; Hopkins P; Chambers D, 2019, 'Reconstruction of Transcriptional Programs of Monocyte to Macrophage Sequential Cell Fate Transition Using Single Cell RNA Sequencing in Sex Mis-Matched Lung Transplantation', The Journal of Heart and Lung Transplantation, vol. 38, pp. S157 - S157, http://dx.doi.org/10.1016/j.healun.2019.01.375
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    Senabouth A; Lukowski SW; Hernandez JA; Andersen SB; Mei X; Nguyen QH; Powell JE, 2019, 'Ascend: R package for analysis of single-cell RNA-seq data', GigaScience, vol. 8, http://dx.doi.org/10.1093/gigascience/giz087
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    Timmers PRHJ; Mounier N; Lall K; Fischer K; Ning Z; Feng X; Bretherick AD; Clark DW; Shen X; Esko T; Kutalik Z; Wilson JF; Joshi PK, 2019, 'Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances', eLife, vol. 8, pp. 1 - 40, http://dx.doi.org/10.7554/elife.39856
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    Wang H; Zhang F; Zeng J; Wu Y; Kemper KE; Xue A; Zhang M; Powell JE; Goddard ME; Wray NR; Visscher PM; McRae AF; Yang J, 2019, 'Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank', Science Advances, vol. 5, http://dx.doi.org/10.1126/sciadv.aaw3538
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    Xu J; Falconer C; Nguyen Q; Crawford J; McKinnon BD; Mortlock S; Senabouth A; Andersen S; Chiu HS; Jiang L; Palpant NJ; Yang J; Mueller MD; Hewitt AW; Pébay A; Montgomery GW; Powell JE; Coin LJM, 2019, 'Genotype-free demultiplexing of pooled single-cell RNA-seq', Genome Biology, vol. 20, http://dx.doi.org/10.1186/s13059-019-1852-7
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    Zeng B; Lloyd-Jones LR; Montgomery GW; Metspalu A; Esko T; Franke L; Vosa U; Claringbould A; Brigham KL; Quyyumi AA; Idaghdour Y; Yang J; Visscher PM; Powell JE; Gibson G, 2019, 'Comprehensive multiple eQTL detection and its application to GWAS interpretation', Genetics, vol. 212, pp. 905 - 918, http://dx.doi.org/10.1534/genetics.119.302091
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    Daniszewski M; Nguyen Q; Chy HS; Singh V; Crombie DE; Kulkarni T; Liang HH; Sivakumaran P; Lidgerwood GE; Hernández D; Conquest A; Rooney LA; Chevalier S; Andersen SB; Senabouth A; Vickers JC; Mackey DA; Craig JE; Laslett AL; Hewitt AW; Powell JE; Pébay A, 2018, 'Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media', iScience, vol. 7, pp. 30 - 39, http://dx.doi.org/10.1016/j.isci.2018.08.016
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    Daniszewski M; Senabouth A; Nguyen QH; Crombie DE; Lukowski SW; Kulkarni T; Sluch VM; Jabbari JS; Chamling X; Zack DJ; Pébay A; Powell JE; Hewitt AW, 2018, 'Single cell RNA sequencing of stem cell-derived retinal ganglion cells', Scientific Data, vol. 5, http://dx.doi.org/10.1038/sdata.2018.13
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    De Smit E; Lukowski SW; Anderson L; Senabouth A; Dauyey K; Song S; Wyse B; Wheeler L; Chen CY; Cao K; Wong Ten Yuen A; Shuey N; Clarke L; Lopez Sanchez I; Hung SSC; Pébay A; Mackey DA; Brown MA; Hewitt AW; Powell JE, 2018, 'Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis', BMC Medical Genomics, vol. 11, http://dx.doi.org/10.1186/s12920-018-0376-4
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    Friedman CE; Nguyen Q; Lukowski SW; Helfer A; Chiu HS; Miklas J; Levy S; Suo S; Han JDJ; Osteil P; Peng G; Jing N; Baillie GJ; Senabouth A; Christ AN; Bruxner TJ; Murry CE; Wong ES; Ding J; Wang Y; Hudson J; Ruohola-Baker H; Bar-Joseph Z; Tam PPL; Powell JE; Palpant NJ, 2018, 'Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation', Cell Stem Cell, vol. 23, pp. 586 - 598.e8, http://dx.doi.org/10.1016/j.stem.2018.09.009
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    Fung JN; Mortlock S; Girling JE; Holdsworth-Carson SJ; Teh WT; Zhu Z; Lukowski SW; McKinnon BD; McRae A; Yang J; Healey M; Powell JE; Rogers PAW; Montgomery GW, 2018, 'Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-29462-y
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    Gerring ZF; Powell JE; Montgomery GW; Nyholt DR, 2018, 'Genome-wide analysis of blood gene expression in migraine implicates immune-inflammatory pathways', Cephalalgia, vol. 38, pp. 292 - 303, http://dx.doi.org/10.1177/0333102416686769
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    Lukowski SW; Tuong ZK; Noske K; Senabouth A; Nguyen QH; Andersen SB; Soyer HP; Frazer IH; Powell JE, 2018, 'Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis', Journal of Investigative Dermatology, vol. 138, pp. 2558 - 2567, http://dx.doi.org/10.1016/j.jid.2018.06.169
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    MacGregor S; Ong JS; An J; Han X; Zhou T; Siggs OM; Law MH; Souzeau E; Sharma S; Lynn DJ; Beesley J; Sheldrick B; Mills RA; Landers J; Ruddle JB; Graham SL; Healey PR; White AJR; Casson RJ; Best S; Grigg JR; Goldberg I; Powell JE; Whiteman DC; Radford-Smith GL; Martin NG; Montgomery GW; Burdon KP; Mackey DA; Gharahkhani P; Craig JE; Hewitt AW, 2018, 'Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma', Nature Genetics, vol. 50, pp. 1067 - 1071, http://dx.doi.org/10.1038/s41588-018-0176-y
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    McRae AF; Marioni RE; Shah S; Yang J; Powell JE; Harris SE; Gibson J; Henders AK; Bowdler L; Painter JN; Murphy L; Martin NG; Starr JM; Wray NR; Deary IJ; Visscher PM; Montgomery GW, 2018, 'Identification of 55,000 Replicated DNA Methylation QTL', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-35871-w
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    Nguyen QH; Lukowski SW; Chiu HS; Senabouth A; Bruxner TJC; Christ AN; Palpant NJ; Powell JE, 2018, 'Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations', Genome Research, vol. 28, pp. 1053 - 1066, http://dx.doi.org/10.1101/gr.223925.117
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    Pinese M; Lacaze P; Rath E; Stone A; Brion M-J; Ameur A; Nagpal S; Puttick C; Husson S; Degrave D; Navin Cristina T; Silva Kahl V; Statham A; Woods R; McNeil J; Riaz M; Barr M; Nelson M; Reid C; Murray A; Shah R; Wolfe R; Atkins J; Fitzsimmons C; Cairns H; Green M; Carr V; Cowley M; Pickett H; James P; Powell J; Kaplan W; Gibson G; Gyllensten U; Cairns M; McNamara M; Dinger M; Thomas D, 2018, 'The Medical Genome Reference Bank: Whole genomes and phenotype of 2,570 healthy elderly', bioRxiv, http://dx.doi.org/10.1101/473348
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    Qi T; Wu Y; Zeng J; Zhang F; Xue A; Jiang L; Zhu Z; Kemper K; Yengo L; Zheng Z; Agbessi M; Ahsan H; Alves I; Andiappan A; Awadalla P; Battle A; Beutner F; Jan Bonder M; Boomsma D; Christiansen M; Claringbould A; Deelen P; Esko T; Favé MJ; Franke L; Frayling T; Gharib S; Gibson G; Hemani G; Jansen R; Kähönen M; Kalnapenkis A; Kasela S; Kettunen J; Kim Y; Kirsten H; Kovacs P; Krohn K; Kronberg-Guzman J; Kukushkina V; Kutalik Z; Lee B; Lehtimäki T; Loeffler M; Marigorta UM; Metspalu A; Milani L; Müller-Nurasyid M; Nauck M; Nivard M; Penninx B; Perola M; Pervjakova N; Pierce B; Powell J; Prokisch H; Psaty B; Raitakari O; Ring S; Ripatti S; Rotzschke O; Ruëger S; Saha A; Scholz M; Schramm K; Seppälä I; Stumvoll M; Sullivan P; Teumer A; Thiery J; Tong L; Tönjes A; Van Dongen J; Van Meurs J; Verlouw J; Völker U; Võsa U; Yaghootkar H; Zeng B; Marioni RE; Montgomery GW; Deary IJ; Wray NR; Visscher PM; McRae AF; Yang J, 2018, 'Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-04558-1
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    Qiao Z; Powell JE; Evans DM, 2018, 'MHC-dependent mate selection within 872 spousal pairs of european ancestry from the Health and Retirement Study', Genes, vol. 9, http://dx.doi.org/10.3390/genes9010053
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    Ramnath D; Irvine KM; Lukowski SW; Horsfall LU; Loh Z; Clouston AD; Patel PJ; Fagan KJ; Iyer A; Lampe G; Stow JL; Schroder K; Fairlie DP; Powell JE; Powell EE; Sweet MJ, 2018, 'Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes', JCI insight, vol. 3, http://dx.doi.org/10.1172/jci.insight.120274
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    Yap CX; Lloyd-Jones L; Holloway A; Smartt P; Wray NR; Gratten J; Powell JE, 2018, 'Trans-eQTLs identified in whole blood have limited influence on complex disease biology', European Journal of Human Genetics, vol. 26, pp. 1361 - 1368, http://dx.doi.org/10.1038/s41431-018-0174-7
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    Zeng J; De Vlaming R; Wu Y; Robinson MR; Lloyd-Jones LR; Yengo L; Yap CX; Xue A; Sidorenko J; McRae AF; Powell JE; Montgomery GW; Metspalu A; Esko T; Gibson G; Wray NR; Visscher PM; Yang J, 2018, 'Signatures of negative selection in the genetic architecture of human complex traits', Nature Genetics, vol. 50, pp. 746 - 753, http://dx.doi.org/10.1038/s41588-018-0101-4
    Journal articles | 2017
    Fung JN; Girling JE; Lukowski SW; Sapkota Y; Wallace L; Holdsworth-Carson SJ; Henders AK; Healey M; Rogers PAW; Powell JE; Montgomery GW, 2017, 'The genetic regulation of transcription in human endometrial tissue', Human Reproduction, vol. 32, pp. 893 - 904, http://dx.doi.org/10.1093/humrep/dex006
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    Lloyd-Jones LR; Holloway A; McRae A; Yang J; Small K; Zhao J; Zeng B; Bakshi A; Metspalu A; Dermitzakis M; Gibson G; Spector T; Montgomery G; Esko T; Visscher PM; Powell JE, 2017, 'Erratum: The Genetic Architecture of Gene Expression in Peripheral Blood (American Journal of Human Genetics (2017) 100(2) (228–237)(S0002929716305328)(10.1016/j.ajhg.2016.12.008)', American Journal of Human Genetics, vol. 100, pp. 371, http://dx.doi.org/10.1016/j.ajhg.2017.01.026
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    Lloyd-Jones LR; Holloway A; McRae A; Yang J; Small K; Zhao J; Zeng B; Bakshi A; Metspalu A; Dermitzakis M; Gibson G; Spector T; Montgomery G; Esko T; Visscher PM; Powell JE, 2017, 'The Genetic Architecture of Gene Expression in Peripheral Blood', American Journal of Human Genetics, vol. 100, pp. 228 - 237, http://dx.doi.org/10.1016/j.ajhg.2016.12.008
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    Lukowski SW; Lloyd-Jones LR; Holloway A; Kirsten H; Hemani G; Yang J; Small K; Zhao J; Metspalu A; Dermitzakis ET; Gibson G; Spector TD; Thiery J; Scholz M; Montgomery GW; Esko T; Visscher PM; Powell JE, 2017, 'Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00473-z
    Journal articles | 2017
    Nayler SP; Powell JE; Vanichkina DP; Korn O; Wells CA; Kanjhan R; Sun J; Taft RJ; Lavin MF; Wolvetang EJ, 2017, 'Human iPSC-derived cerebellar neurons from a patient with ataxia-telangiectasia reveal disrupted gene regulatory networks', Frontiers in Cellular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fncel.2017.00321
    Journal articles | 2017
    Robins C; McRae AF; Powell JE; Wiener HW; Aslibekyan S; Kennedy EM; Absher DM; Arnett DK; Montgomery GW; Visscher PM; Cutler DJ; Conneely KN, 2017, 'Testing two evolutionary theories of human aging with DNA methylation data', Genetics, vol. 207, pp. 1547 - 1560, http://dx.doi.org/10.1534/genetics.117.300217
    Journal articles | 2017
    Zeng B; Lloyd-Jones LR; Holloway A; Marigorta UM; Metspalu A; Montgomery GW; Esko T; Brigham KL; Quyyumi AA; Idaghdour Y; Yang J; Visscher PM; Powell JE; Gibson G, 2017, 'Constraints on eQTL fine mapping in the presence of multisite local regulation of gene expression', G3: Genes, Genomes, Genetics, vol. 7, pp. 2533 - 2544, http://dx.doi.org/10.1534/g3.117.043752
    Journal articles | 2016
    Gerring Z; Rodriguez-Acevedo AJ; Powell JE; Griffiths LR; Montgomery GW; Nyholt DR, 2016, 'Blood gene expression studies in migraine: Potential and caveats', Cephalalgia, vol. 36, pp. 669 - 678, http://dx.doi.org/10.1177/0333102416628463
    Journal articles | 2016
    Holdsworth-Carson SJ; Fung JN; Luong HTT; Sapkota Y; Bowdler LM; Wallace L; Teh WT; Powell JE; Girling JE; Healey M; Montgomery GW; Rogers PAW, 2016, 'Endometrial vezatin and its association with endometriosis risk', Human Reproduction, vol. 31, pp. 999 - 1013, http://dx.doi.org/10.1093/humrep/dew047
    Journal articles | 2016
    Hung SSC; Chrysostomou V; Li F; Lim JKH; Wang JH; Powell JE; Tu L; Daniszewski M; Lo C; Wong RC; Crowston JG; Pébay A; King AE; Bui BV; Liu GS; Hewitt AW, 2016, 'AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells in Vivo', Investigative Ophthalmology and Visual Science, vol. 57, pp. 3470 - 3476, http://dx.doi.org/10.1167/iovs.16-19316
    Journal articles | 2016
    Kassam I; Lloyd-Jones L; Holloway A; Small KS; Zeng B; Bakshi A; Metspalu A; Gibson G; Spector TD; Esko T; Montgomery GW; Powell JE; Yang J; Visscher PM; McRae AF, 2016, 'Autosomal genetic control of human gene expression does not differ across the sexes', Genome Biology, vol. 17, http://dx.doi.org/10.1186/s13059-016-1111-0
    Journal articles | 2016
    Kassam I; Qi T; Lloyd-Jones L; Holloway A; Bonder MJ; Henders AK; Martin NG; Powell JE; Franke L; Montgomery GW; Visscher PM; McRae AF, 2016, 'Evidence for mitochondrial genetic control of autosomal gene expression', Human Molecular Genetics, vol. 25, pp. 5332 - 5338, http://dx.doi.org/10.1093/hmg/ddw347
    Journal articles | 2016
    McKay FC; Gatt PN; Fewings N; Parnell GP; Schibeci SD; Basuki MAI; Powell JE; Goldinger A; Fabis-Pedrini MJ; Kermode AG; Burke T; Vucic S; Stewart GJ; Booth DR, 2016, 'The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies', Clinical Immunology, vol. 163, pp. 96 - 107, http://dx.doi.org/10.1016/j.clim.2015.12.015
    Journal articles | 2016
    Pilling LC; Joehanes R; Kacprowski T; Peters M; Jansen R; Karasik D; Kiel DP; Harries LW; Teumer A; Powell J; Levy D; Lin H; Lunetta K; Munson P; Bandinelli S; Henley W; Hernandez D; Singleton A; Tanaka T; van Grootheest G; Hofman A; Uitterlinden AG; Biffar R; Gläser S; Homuth G; Malsch C; Völker U; Penninx B; van Meurs JBJ; Ferrucci L; Kocher T; Murabito J; Melzer D, 2016, 'Gene transcripts associated with muscle strength: A CHARGE meta-analysis of 7,781 persons', Physiological Genomics, vol. 48, pp. 1 - 11, http://dx.doi.org/10.1152/physiolgenomics.00054.2015
    Journal articles | 2016
    Powell JE; Fung JN; Shakhbazov K; Sapkota Y; Cloonan N; Hemani G; Hillman KM; Kaufmann S; Luong HT; Bowdler L; Painter JN; Holdsworth-Carson SJ; Visscher PM; Dinger ME; Healey M; Nyholt DR; French JD; Edwards SL; Rogers PAW; Montgomery GW, 2016, 'Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339', Human Molecular Genetics, vol. 25, pp. 5046 - 5058, http://dx.doi.org/10.1093/hmg/ddw320
    Journal articles | 2016
    Shakhbazov K; Powell JE; Hemani G; Henders AK; Martin NG; Visscher PM; Montgomery GW; McRae AF, 2016, 'Shared genetic control of expression and methylation in peripheral blood', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2498-4
    Journal articles | 2016
    Zhu Z; Zhang F; Hu H; Bakshi A; Robinson MR; Powell JE; Montgomery GW; Goddard ME; Wray NR; Visscher PM; Yang J, 2016, 'Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets', Nature Genetics, vol. 48, pp. 481 - 487, http://dx.doi.org/10.1038/ng.3538
    Journal articles | 2015
    Benyamin B; Esko T; Ried JS; Radhakrishnan A; Vermeulen SH; Traglia M; Gögele M; Anderson D; Broer L; Podmore C; Luan J; Kutalik Z; Sanna S; Van Der Meer P; Tanaka T; Wang F; Westra HJ; Franke L; Mihailov E; Milani L; Hälldin J; Winkelmann J; Meitinger T; Thiery J; Peters A; Waldenberger M; Rendon A; Jolley J; Sambrook J; Kiemeney LA; Sweep FC; Sala CF; Schwienbacher C; Pichler I; Hui J; Demirkan A; Isaacs A; Amin N; Steri M; Waeber G; Verweij N; Powell JE; Nyholt DR; Heath AC; Madden PAF; Visscher PM; Wright MJ; Montgomery GW; Martin NG; Hernandez D; Bandinelli S; Van Der Harst P; Uda M; Vollenweider P; Scott RA; Langenberg C; Wareham NJ; Van Duijn C; Beilby J; Pramstaller PP; Hicks AA; Ouwehand WH; Oexle K; Gieger C; Metspalu A; Camaschella C; Toniolo D; Swinkels DW; Whitfield JB, 2015, 'Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms7542
    Journal articles | 2015
    Gibson G; Powell JE; Marigorta UM, 2015, 'Expression quantitative trait locus analysis for translational medicine', Genome Medicine, vol. 7, http://dx.doi.org/10.1186/s13073-015-0186-7
    Journal articles | 2015
    Goldinger A; Shakhbazov K; Henders AK; McRae AF; Montgomery GW; Powell JE, 2015, 'Seasonal effects on gene expression', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126995
    Journal articles | 2015
    McGovern AE; Driessen AK; Simmons DG; Powell J; Davis-Poynter N; Farrell MJ; Mazzone SB, 2015, 'Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system', Journal of Neuroscience, vol. 35, pp. 7041 - 7055, http://dx.doi.org/10.1523/JNEUROSCI.5128-14.2015
    Journal articles | 2015
    Peters MJ; Joehanes R; Pilling LC; Schurmann C; Conneely KN; Powell J; Reinmaa E; Sutphin GL; Zhernakova A; Schramm K; Wilson YA; Kobes S; Tukiainen T; Ramos YF; Göring HHH; Fornage M; Liu Y; Gharib SA; Stranger BE; De Jager PL; Aviv A; Levy D; Murabito JM; Munson PJ; Huan T; Hofman A; Uitterlinden AG; Rivadeneira F; Van Rooij J; Stolk L; Broer L; Verbiest MMPJ; Jhamai M; Arp P; Metspalu A; Tserel L; Milani L; Samani NJ; Peterson P; Kasela S; Codd V; Peters A; Ward-Caviness CK; Herder C; Waldenberger M; Roden M; Singmann P; Zeilinger S; Illig T; Homuth G; Grabe HJ; Völzke H; Steil L; Kocher T; Murray A; Melzer D; Yaghootkar H; Bandinelli S; Moses EK; Kent JW; Curran JE; Johnson MP; Williams-Blangero S; Westra HJ; McRae AF; Smith JA; Kardia SLR; Hovatta I; Perola M; Ripatti S; Salomaa V; Henders AK; Martin NG; Smith AK; Mehta D; Binder EB; Nylocks KM; Kennedy EM; Klengel T; Ding J; Suchy-Dicey AM; Enquobahrie DA; Brody J; Rotter JI; Chen YDI; Houwing-Duistermaat J; Kloppenburg M; Slagboom PE; Helmer Q; Den Hollander W; Bean S; Raj T; Bakhshi N; Wang QP; Oyston LJ; Psaty BM; Tracy RP; Montgomery GW; Turner ST; Blangero J, 2015, 'The transcriptional landscape of age in human peripheral blood', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9570
    Journal articles | 2015
    Robinson MR; Hemani G; Medina-Gomez C; Mezzavilla M; Esko T; Shakhbazov K; Powell JE; Vinkhuyzen A; Berndt SI; Gustafsson S; Justice AE; Kahali B; Locke AE; Pers TH; Vedantam S; Wood AR; Van Rheenen W; Andreassen OA; Gasparini P; Metspalu A; Van Den Berg LH; Veldink JH; Rivadeneira F; Werge TM; Abecasis GR; Boomsma DI; Chasman DI; De Geus EJC; Frayling TM; Hirschhorn JN; Hottenga JJ; Ingelsson E; Loos RJF; Magnusson PKE; Martin NG; Montgomery GW; North KE; Pedersen NL; Spector TD; Speliotes EK; Goddard ME; Yang J; Visscher PM, 2015, 'Population genetic differentiation of height and body mass index across Europe', Nature Genetics, vol. 47, pp. 1357 - 1361, http://dx.doi.org/10.1038/ng.3401
    Journal articles | 2015
    Robinson PC; Claushuis TAM; Cortes A; Martin TM; Evans DM; Leo P; Mukhopadhyay P; Bradbury LA; Cremin K; Harris J; Maksymowych WP; Inman RD; Rahman P; Haroon N; Gensler L; Powell JE; Van Der Horst-Bruinsma IE; Hewitt AW; Craig JE; Lim LL; Wakefield D; McCluskey P; Voigt V; Fleming P; Degli-Esposti M; Pointon JJ; Weisman MH; Wordsworth BP; Reveille JD; Rosenbaum JT; Brown MA, 2015, 'Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis', Arthritis and Rheumatology, vol. 67, pp. 140 - 151, http://dx.doi.org/10.1002/art.38873
    Journal articles | 2014
    Benyamin B; Esko T; Ried JS; Radhakrishnan A; Vermeulen SH; Traglia M; Gögele M; Anderson D; Broer L; Podmore C; Luan J; Kutalik Z; Sanna S; Van Der Meer P; Tanaka T; Wang F; Westra HJ; Franke L; Mihailov E; Milani L; Häldin J; Winkelmann J; Meitinger T; Thiery J; Peters A; Waldenberger M; Rendon A; Jolley J; Sambrook J; Kiemeney LA; Sweep FC; Sala CF; Schwienbacher C; Pichler I; Hui J; Demirkan A; Isaacs A; Amin N; Steri M; Waeber G; Verweij N; Powell JE; Nyholt DR; Heath AC; Madden PAF; Visscher PM; Wright MJ; Montgomery GW; Martin NG; Hernandez D; Bandinelli S; Van Der Harst P; Uda M; Vollenweider P; Scott RA; Langenberg C; Wareham NJ; Van Duijn C; Beilby J; Pramstaller PP; Hicks AA; Ouwehand WH; Oexle K; Gieger C; Metspalu A; Camaschella C; Toniolo D; Swinkels DW; Whitfield JB, 2014, 'Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms5926
    Journal articles | 2014
    Hemani G; Shakhbazov K; Westra HJ; Esko T; Henders AK; McRae AF; Yang J; Gibson G; Martin NG; Metspalu A; Franke L; Montgomery GW; Visscher PM; Powell JE, 2014, 'Detection and replication of epistasis influencing transcription in humans', Nature, vol. 508, pp. 249 - 253, http://dx.doi.org/10.1038/nature13005
    Journal articles | 2014
    Hemani G; Shakhbazov K; Westra HJ; Esko T; Henders AK; McRae AF; Yang J; Gibson G; Martin NG; Metspalu A; Franke L; Montgomery GW; Visscher PM; Powell JE, 2014, 'Hemani et al. reply', Nature, vol. 514, pp. E5 - E6, http://dx.doi.org/10.1038/nature13692
    Journal articles | 2014
    McKenzie M; Henders AK; Caracella A; Wray NR; Powell JE, 2014, 'Overlap of expression Quantitative Trait Loci (eQTL) in human brain and blood', BMC Medical Genomics, vol. 7, http://dx.doi.org/10.1186/1755-8794-7-31
    Journal articles | 2014
    McRae AF; Powell JE; Henders AK; Bowdler L; Hemani G; Shah S; Painter JN; Martin NG; Visscher PM; Montgomery GW, 2014, 'Contribution of genetic variation to transgenerational inheritance of DNA methylation', Genome biology, vol. 15, pp. R73, http://dx.doi.org/10.1186/gb-2014-15-5-r73
    Journal articles | 2014
    Parnell GP; Gatt PN; McKay FC; Schibeci S; Krupa M; Powell JE; Visscher PM; Montgomery GW; Lechner-Scott J; Broadley S; Liddle C; Slee M; Vucic S; Stewart GJ; Booth DR, 2014, 'Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season', Multiple Sclerosis Journal, vol. 20, pp. 675 - 685, http://dx.doi.org/10.1177/1352458513507819
    Journal articles | 2014
    Ripke S; Neale BM; Corvin A; Walters JTR; Farh KH; Holmans PA; Lee P; Bulik-Sullivan B; Collier DA; Huang H; Pers TH; Agartz I; Agerbo E; Albus M; Alexander M; Amin F; Bacanu SA; Begemann M; Belliveau RA; Bene J; Bergen SE; Bevilacqua E; Bigdeli TB; Black DW; Bruggeman R; Buccola NG; Buckner RL; Byerley W; Cahn W; Cai G; Campion D; Cantor RM; Carr VJ; Carrera N; Catts SV; Chambert KD; Chan RCK; Chen RYL; Chen EYH; Cheng W; Cheung EFC; Chong SA; Cloninger CR; Cohen D; Cohen N; Cormican P; Craddock N; Crowley JJ; Curtis D; Davidson M; Davis KL; Degenhardt F; Del Favero J; Demontis D; Dikeos D; Dinan T; Djurovic S; Donohoe G; Drapeau E; Duan J; Dudbridge F; Durmishi N; Eichhammer P; Eriksson J; Escott-Price V; Essioux L; Fanous AH; Farrell MS; Frank J; Franke L; Freedman R; Freimer NB; Friedl M; Friedman JI; Fromer M; Genovese G; Georgieva L; Giegling I; Giusti-Rodríguez P; Godard S; Goldstein JI; Golimbet V; Gopal S; Gratten J; De Haan L; Hammer C; Hamshere ML; Hansen M; Hansen T; Haroutunian V; Hartmann AM; Henskens FA; Herms S; Hirschhorn JN; Hoffmann P; Hofman A; Hollegaard MV; Hougaard DM; Ikeda M; Joa I, 2014, 'Biological insights from 108 schizophrenia-associated genetic loci', Nature, vol. 511, pp. 421 - 427, http://dx.doi.org/10.1038/nature13595
    Journal articles | 2014
    Wood AR; Esko T; Yang J; Vedantam S; Pers TH; Gustafsson S; Chu AY; Estrada K; Luan J; Kutalik Z; Amin N; Buchkovich ML; Croteau-Chonka DC; Day FR; Duan Y; Fall T; Fehrmann R; Ferreira T; Jackson AU; Karjalainen J; Lo KS; Locke AE; Mägi R; Mihailov E; Porcu E; Randall JC; Scherag A; Vinkhuyzen AAE; Westra HJ; Winkler TW; Workalemahu T; Zhao JH; Absher D; Albrecht E; Anderson D; Baron J; Beekman M; Demirkan A; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Fraser RM; Goel A; Gong J; Justice AE; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Lui JC; Mangino M; Leach IM; Medina-Gomez C; Nalls MA; Nyholt DR; Palmer CD; Pasko D; Pechlivanis S; Prokopenko I; Ried JS; Ripke S; Shungin D; Stancáková A; Strawbridge RJ; Sung YJ; Tanaka T; Teumer A; Trompet S; Van Der Laan SW; Van Setten J; Van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Afzal U; Ärnlöv J; Arscott GM; Bandinelli S; Barrett A; Bellis C; Bennett AJ; Berne C; Blüher M; Bolton JL; Böttcher Y; Boyd HA; Bruinenberg M; Buckley BM; Buyske S; Caspersen IH; Chines PS; Clarke R; Claudi-Boehm S; Cooper M; Daw EW; De Jong PA; Deelen J; Delgado G, 2014, 'Defining the role of common variation in the genomic and biological architecture of adult human height', Nature Genetics, vol. 46, pp. 1173 - 1186, http://dx.doi.org/10.1038/ng.3097
    Journal articles | 2013
    Goldinger A; Henders AK; McRae AF; Martin NG; Gibson G; Montgomery GW; Visscher PM; Powell JE, 2013, 'Genetic and nongenetic variation revealed for the principal components of human gene expression', Genetics, vol. 195, pp. 1117 - 1128, http://dx.doi.org/10.1534/genetics.113.153221
    Journal articles | 2013
    Hemani G; Yang J; Vinkhuyzen A; Powell JE; Willemsen G; Hottenga JJ; Abdellaoui A; Mangino M; Valdes AM; Medland SE; Madden PA; Heath AC; Henders AK; Nyholt DR; De Geus EJC; Magnusson PKE; Ingelsson E; Montgomery GW; Spector TD; Boomsma DI; Pedersen NL; Martin NG; Visscher PM, 2013, 'Inference of the genetic architecture underlying bmi and height with the use of 20,240 sibling pairs', American Journal of Human Genetics, vol. 93, pp. 865 - 875, http://dx.doi.org/10.1016/j.ajhg.2013.10.005
    Journal articles | 2013
    Luong HTT; Painter JN; Shakhbazov K; Chapman B; Henders AK; Powell JE; Nyholt DR; Montgomery GW, 2013, 'Fine mapping of variants associated with endometriosis in the WNT4 region on chromosome 1p36', International Journal of Molecular Epidemiology and Genetics, vol. 4, pp. 193 - 206
    Journal articles | 2013
    Powell JE; Henders AK; McRae AF; Kim J; Hemani G; Martin NG; Dermitzakis ET; Gibson G; Montgomery GW; Visscher PM, 2013, 'Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data', PLoS Genetics, vol. 9, http://dx.doi.org/10.1371/journal.pgen.1003502
    Journal articles | 2013
    Revez JA; Bain L; Chapman B; Powell JE; Jansen R; Duffy DL; Tung JY; Collaborators AAGC; Matheson MC; Marks GB; Hui J; Le Souëf P; Danoy P; Baltic S; Nyholt DR; Jenkins M; Hayden C; Beilby J; Cheah F; Madden PA; Heath AC; Hopper JL; Musk B; Leeder SR; Walters EH; James A; Jones G; Abramson MJ; Robertson CF; Dharmage SC; Brown MA; Thompson PJ; Penninx BW; Visscher PM; De Geus EJC; Boomsma DI; Hinds DA; Martin NG; Montgomery GW; Ferreira MAR, 2013, 'A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk', Genes and Immunity, vol. 14, pp. 441 - 446, http://dx.doi.org/10.1038/gene.2013.38
    Journal articles | 2013
    Westra HJ; Peters MJ; Esko T; Yaghootkar H; Schurmann C; Kettunen J; Christiansen MW; Fairfax BP; Schramm K; Powell JE; Zhernakova A; Zhernakova DV; Veldink JH; Van Den Berg LH; Karjalainen J; Withoff S; Uitterlinden AG; Hofman A; Rivadeneira F; Hoen PAC; Reinmaa E; Fischer K; Nelis M; Milani L; Melzer D; Ferrucci L; Singleton AB; Hernandez DG; Nalls MA; Homuth G; Nauck M; Radke D; Völker U; Perola M; Salomaa V; Brody J; Suchy-Dicey A; Gharib SA; Enquobahrie DA; Lumley T; Montgomery GW; Makino S; Prokisch H; Herder C; Roden M; Grallert H; Meitinger T; Strauch K; Li Y; Jansen RC; Visscher PM; Knight JC; Psaty BM; Ripatti S; Teumer A; Frayling TM; Metspalu A; Van Meurs JBJ; Franke L, 2013, 'Systematic identification of trans eQTLs as putative drivers of known disease associations', Nature Genetics, vol. 45, pp. 1238 - 1243, http://dx.doi.org/10.1038/ng.2756
    Journal articles | 2012
    Gordon L; Joo JE; Powell JE; Ollikainen M; Novakovic B; Li X; Andronikos R; Cruickshank MN; Conneely KN; Smith AK; Alisch RS; Morley R; Visscher PM; Craig JM; Saffery R, 2012, 'Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence', Genome Research, vol. 22, pp. 1395 - 1406, http://dx.doi.org/10.1101/gr.136598.111
    Journal articles | 2012
    Powell JE; Henders AK; McRae AF; Caracella A; Smith S; Wright MJ; Whitfield JB; Dermitzakis ET; Martin NG; Visscher PM; Montgomery GW, 2012, 'The Brisbane systems genetics study: Genetical genomics meets complex trait genetics', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0035430
    Journal articles | 2012
    Powell JE; Henders AK; McRae AF; Wright MJ; Martin NG; Dermitzakis ET; Montgomery GW; Visscher PM, 2012, 'Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent', Genome Research, vol. 22, pp. 456 - 466, http://dx.doi.org/10.1101/gr.126540.111
    Journal articles | 2012
    Powell JE; Kranis A; Floyd J; Dekkers JCM; Knott S; Haley CS, 2012, 'Optimal use of regression models in genome-wide association studies', ANIMAL GENETICS, vol. 43, pp. 133 - 143, http://dx.doi.org/10.1111/j.1365-2052.2011.02234.x
    Journal articles | 2012
    Yang J; Loos RJF; Powell JE; Medland SE; Speliotes EK; Chasman DI; Rose LM; Thorleifsson G; Steinthorsdottir V; Mägi R; Waite L; Vernon Smith A; Yerges-Armstrong LM; Monda KL; Hadley D; Mahajan A; Li G; Kapur K; Vitart V; Huffman JE; Wang SR; Palmer C; Esko T; Fischer K; Hua Zhao J; Demirkan A; Isaacs A; Feitosa MF; Luan J; Heard-Costa NL; White C; Jackson AU; Preuss M; Ziegler A; Eriksson J; Kutalik Z; Frau F; Nolte IM; Van Vliet-Ostaptchouk JV; Hottenga JJ; Jacobs KB; Verweij N; Goel A; Medina-Gomez C; Estrada K; Bragg-Gresham JL; Sanna S; Sidore C; Tyrer J; Teumer A; Prokopenko I; Mangino M; Lindgren CM; Assimes TL; Shuldiner AR; Hui J; Beilby JP; McArdle WL; Hall P; Haritunians T; Zgaga L; Kolcic I; Polasek O; Zemunik T; Oostra BA; Juhani Junttila M; Grönberg H; Schreiber S; Peters A; Hicks AA; Stephens J; Foad NS; Laitinen J; Pouta A; Kaakinen M; Willemsen G; Vink JM; Wild SH; Navis G; Asselbergs FW; Homuth G; John U; Iribarren C; Harris T; Launer L; Gudnason V; O'Connell JR; Boerwinkle E; Cadby G; Palmer LJ; James AL; Musk AW; Ingelsson E; Psaty BM; Beckmann JS; Waeber G; Vollenweider P; Hayward C; Wright AF; Rudan I, 2012, 'FTO genotype is associated with phenotypic variability of body mass index', Nature, vol. 490, pp. 267 - 273, http://dx.doi.org/10.1038/nature11401
    Journal articles | 2011
    Maugeri N; Powell JE; 't Hoen PAC; de Geus EJC; Willemsen G; Kattenberg M; Henders AK; Wallace L; Penninx B; Hottenga JJ; Medland SE; Saviouk V; Martin NG; Visscher PM; van Ommen GJB; Frazer IH; Boomsma DI; Montgomery GW; Ferreira MAR, 2011, 'LPAR1 and ITGA4 regulate peripheral blood monocyte counts', Human Mutation, vol. 32, pp. 873 - 876, http://dx.doi.org/10.1002/humu.21536
    Journal articles | 2011
    McEvoy BP; Powell JE; Goddard ME; Visscher PM, 2011, 'Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs', Genome Research, vol. 21, pp. 821 - 829, http://dx.doi.org/10.1101/gr.119636.110
    Journal articles | 2011
    Powell JE; Zietsch BP, 2011, 'Predicting sensation seeking from dopamine genes: Use and misuse of genetic prediction', Psychological Science, vol. 22, pp. 413 - 415, http://dx.doi.org/10.1177/0956797610397669
    Journal articles | 2010
    Powell JE; Visscher PM; Goddard ME, 2010, 'Reconciling the analysis of IBD and IBS in complex trait studies', Nature Reviews Genetics, vol. 11, pp. 800 - 805, http://dx.doi.org/10.1038/nrg2865
    Journal articles | 2009
    Lam AC; Powell J; Wei W-H; de Koning D-J; Haley CS, 2009, 'A combined strategy for quantitative trait loci detection by genome-wide association.', BMC Proc, vol. 3 Suppl 1, pp. S6, http://dx.doi.org/10.1186/1753-6561-3-s1-s6
    Journal articles | 2008
    Powell J; White I; Guy D; Brotherstone S, 2008, 'Genetic parameters of production traits in Atlantic salmon (Salmo salar)', AQUACULTURE, vol. 274, pp. 225 - 231, http://dx.doi.org/10.1016/j.aquaculture.2007.11.036
  • Preprints | 2022
    Grimm L; Mason E; Yu O; Dudczig S; Panara V; Chen T; Bower NI; Paterson S; Okuda K; Galeano MR; Kobayashi S; Senabouth A; Lagendijk AK; Powell J; Smith KA; Koltowska K; Hogan BM, 2022, Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development, http://dx.doi.org/10.1101/2022.02.10.479999
    Preprints | 2022
    Maksimovic J; Shanthikumar S; Howitt G; Hickey PF; Ho W; Anttila C; Brown DV; Senabouth A; Kaczorowski D; Amann-Zalcenstein D; Powell JE; Ranganathan SC; Oshlack A; Neeland MR, 2022, Multimodal single cell analysis of the paediatric lower airway reveals novel immune cell phenotypes in early life health and disease, http://dx.doi.org/10.1101/2022.06.17.496207
    Preprints | 2022
    Neavin D; Senabouth A; Hang Lee JT; Ripoll A; Franke L; Prabhakar S; Ye CJ; McCarthy DJ; Melé M; Hemberg M; Powell JE, 2022, Demuxafy: Improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods, http://dx.doi.org/10.1101/2022.03.07.483367
    Preprints | 2022
    Xue A; Yazar S; Neavin D; Powell JE, 2022, Pitfalls and opportunities for applying PEER factors in single-cell eQTL analyses, http://dx.doi.org/10.1101/2022.08.02.502566
    Preprints | 2021
    Daniszewski MS; Senabouth A; Liang HH; Han X; Lidgerwood GE; Hernández D; Sivakumaran P; Clarke JE; Lim SY; Lees JG; Rooney L; Gulluyan L; Souzeau E; Graham SL; Chan C-L; Nguyen U; Farbehi N; Gnanasambandapillai V; McCloy RA; Clarke L; Kearns L; Mackey DA; Craig JE; MacGregor S; Powell JE; Pébay A; Hewitt AW, 2021, Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma, http://dx.doi.org/10.1101/2021.07.14.452417
    Preprints | 2021
    Muskovic W; Powell JE, 2021, DropletQC: improved identification of empty droplets and damaged cells in single-cell RNA-seq data, http://dx.doi.org/10.1101/2021.08.02.454717
    Preprints | 2021
    Neavin DR; Steinmann AM; Chiu HS; Daniszewski MS; Moutinho C; Chan C-L; Tyebally M; Gnanasambandapillai V; Lam CE; Nguyen U; Hernández D; Lidgerwood GE; Hewitt AW; Pébay A; Palpant NJ; Powell JE, 2021, Village in a dish: a model system for population-scale hiPSC studies, http://dx.doi.org/10.1101/2021.08.19.457030
    Preprints | 2021
    Patel B; Kleeman SO; Neavin D; Powell J; Baskozos G; Ng M; Ahmed W-U-R; Bennett DL; Schmid A; Furniss D; Wiberg A, 2021, DIRC3-IGFBP5 is a shared genetic risk locus and therapeutic target for carpal tunnel syndrome and trigger finger, http://dx.doi.org/10.1101/2021.10.07.21264697
    Preprints | 2021
    Phipson B; Sim CB; Porrello ER; Hewitt AW; Powell J; Oshlack A, 2021, propeller: testing for differences in cell type proportions in single cell data, http://dx.doi.org/10.1101/2021.11.28.470236
    Preprints | 2021
    Senabouth A; Daniszewski M; Lidgerwood GE; Liang HH; Hernández D; Mirzaei M; Zhang R; Han X; Neavin D; Rooney L; Sanchez IL; Gulluyan L; Paulo JA; Clarke L; Kearns LS; Gnanasambandapillai V; Chan C-L; Nguyen U; Steinmann AM; Zekanovic R; Farbehi N; Gupta VK; Mackey DA; Bylsma G; Verma N; MacGregor S; Guymer RH; Powell JE; Hewitt AW; Pébay A, 2021, Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration, http://dx.doi.org/10.1101/2021.08.19.457044
    Preprints | 2021
    Talenti A; Powell J; Hemmink JD; Cook EAJ; Wragg D; Jayaraman S; Paxton E; Ezeasor C; Obishakin ET; Agusi ER; Tijjani A; Marshall K; Fisch A; Ferreira B; Qasim A; Chaudhry UN; Wiener P; P. T; Morrison LJ; Connelley T; Prendergast J, 2021, A cattle graph genome incorporating global breed diversity, http://dx.doi.org/10.1101/2021.06.23.449389
    Preprints | 2021
    Wilson SB; Howden SE; Vanslambrouck JM; Dorison A; Alquicira-Hernandez J; Powell JE; Little MH, 2021, DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets, http://dx.doi.org/10.1101/2021.01.20.427346
    Preprints | 2020
    Alquicira-Hernandez J; Powell JE, 2020, Nebulosa recovers single cell gene expression signals by kernel density estimation, http://dx.doi.org/10.1101/2020.09.29.315879
    Preprints | 2020
    Alquicira-Hernandez J; Powell JE; Phan TG, 2020, No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease, http://dx.doi.org/10.1101/2020.09.27.312538
    Preprints | 2020
    Cobos FA; Alquicira-Hernandez J; Powell J; Mestdagh P; De Preter K, 2020, Comprehensive benchmarking of computational deconvolution of transcriptomics data, http://dx.doi.org/10.1101/2020.01.10.897116
    Preprints | 2020
    Engel JA; Lee HJ; Williams CG; Kuns R; Olver S; Lansink LIM; Soon MSF; Andersen SB; Powell JE; Svensson V; Teichmann SA; Hill GR; Varelias A; Koyama M; Haque A, 2020, Single-cell transcriptomics of allo-reactive CD4+ T cells over time reveals divergent fates during gut GVHD, http://dx.doi.org/10.1101/2020.03.08.978239
    Preprints | 2020
    Neavin D; Nguyen Q; Daniszewski MS; Liang HH; Chiu HS; Senabouth A; Lukowski SW; Crombie DE; Lidgerwood GE; Hernández D; Vickers JC; Cook AL; Palpant NJ; Pébay A; Hewitt AW; Powell JE, 2020, Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells, http://dx.doi.org/10.1101/2020.06.21.163766
    Preprints | 2020
    Nieto P; Elosua-Bayes M; Trincado JL; Marchese D; Massoni-Badosa R; Salvany M; Henriques A; Mereu E; Moutinho C; Ruiz S; Lorden P; Chin VT; Kaczorowski D; Chan C-L; Gallagher R; Chou A; Planas-Rigol E; Rubio-Perez C; Gut I; Piulats JM; Seoane J; Powell JE; Batlle E; Heyn H, 2020, A Single-Cell Tumor Immune Atlas for Precision Oncology, http://dx.doi.org/10.1101/2020.10.26.354829
    Conference Abstracts | 2019
    Chin VT; Al Eryani G; McCloy R; Stone E; Havryk A; Plit M; Field A; Watkins N; Swarbrick A; Powell J, 2019, 'Using single cell genomics to change the treatment of lung cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 37, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2019 - 04 June 2019, http://dx.doi.org/10.1200/JCO.2019.37.15_suppl.e20563
    Preprints | 2019
    Lidgerwood GE; Senabouth A; Smith-Anttila CJA; Gnanasambandapillai V; Kaczorowski DC; Amann-Zalcenstein D; Fletcher EL; Naik SH; Hewitt AW; Powell JE; Pébay A, 2019, Transcriptomic Profiling of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Over Time, http://dx.doi.org/10.1101/842328
    Preprints | 2019
    Senabouth A; Andersen S; Shi Q; Shi L; Liu P; Jiang F; Zhang W; Wing K; Daniszewski M; Lukowski SW; Hung SSC; Nguyen Q; Fink L; Beckhouse A; Jiang H; Pébay A; Hewitt AW; Powell JE, 2019, Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing, http://dx.doi.org/10.1101/552588
    Preprints | 2019
    Wang H; Zhang F; Zeng J; Wu Y; Kemper KE; Xue A; Zhang M; Powell JE; Goddard ME; Wray NR; Visscher PM; McRae AF; Yang J, 2019, Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank, http://dx.doi.org/10.1101/519538
    Preprints | 2019
    Xu J; Falconer C; Nguyen Q; Crawford J; McKinnon BD; Mortlock S; Pébay A; Hewitt AW; Senabouth A; Andersen S; Palpant N; Chiu HS; Montgomery GW; Powell J; Coin L, 2019, Genotype-free demultiplexing of pooled single-cell RNA-seq, http://dx.doi.org/10.1101/570614
    Preprints | 2019
    van der Wijst MGP; de Vries DH; Groot HE; Trynka G; Hon C-C; Nawijn MC; Idaghdour Y; van der Harst P; Ye CJ; Powell J; Theis FJ; Mahfouz A; Heinig M; Franke L, 2019, Single-cell eQTLGen Consortium: a personalized understanding of disease, http://dx.doi.org/10.48550/arxiv.1909.12550
    Preprints | 2018
    Alquicira-Hernández J; Sathe A; Ji HP; Nguyen Q; Powell JE, 2018, scPred: Cell type prediction at single-cell resolution, http://dx.doi.org/10.1101/369538
    Preprints | 2018
    De Smit E; Lukowski SW; Anderson L; Senabouth A; Dauyey K; Song S; Wyse B; Wheeler L; Chen CY; Cao K; Yuen AWT; Shuey N; Clarke L; Sanchez IL; Hung SSC; Pébay A; Mackey DA; Brown MA; Hewitt AW; Powell JE, 2018, Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent Giant Cell Arteritis, http://dx.doi.org/10.1101/243493
    Preprints | 2018
    Lukowski SW; Lo CY; Sharov A; Nguyen QH; Fang L; Hung SSC; Zhu L; Zhang T; Nguyen T; Senabouth A; Jabbari JS; Welby E; Sowden JC; Waugh HS; Mackey A; Pollock G; Lamb TD; Wang P-Y; Hewitt AW; Gillies M; Powell JE; Wong RCB, 2018, Generation of human neural retina transcriptome atlas by single cell RNA sequencing, http://dx.doi.org/10.1101/425223
    Preprints | 2017
    Daniszewski M; Senabouth A; Nguyen Q; Crombie DE; Lukowski SW; Kulkarni T; Zack DJ; Pébay A; Powell JE; Hewitt AW, 2017, Single Cell RNA Sequencing of stem cell-derived retinal ganglion cells, http://dx.doi.org/10.1101/191395
    Preprints | 2017
    Friedman CE; Nguyen Q; Lukowski SW; Chiu HS; Helfer A; Miklas J; Suo SS; Jackie Han J-D; Osteil P; Peng G; Jing N; Baillie GJ; Senabouth A; Christ AN; Bruxner TJ; Murry CE; Wong ES; Ding J; Wang Y; Hudson J; Ruohola-Baker H; Bar-Joseph Z; Tam PPL; Powell JE; Palpant NJ, 2017, Analysis of cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcription, http://dx.doi.org/10.1101/229294
    Preprints | 2017
    McRae AF; Marioni RE; Shah S; Yang J; Powell JE; Harris SE; Gibson J; Henders AK; Bowdler L; Painter JN; Murphy L; Martin NG; Starr JM; Wray NR; Deary IJ; Visscher PM; Montgomery GW, 2017, Identification of 55,000 Replicated DNA Methylation QTL, http://dx.doi.org/10.1101/166710
    Preprints | 2017
    Nguyen QH; Lukowski SW; Chiu HS; Friedman CE; Senabouth A; Crowhurst L; Bruxmer TJC; Christ AN; Palpant NJ; Powell JE, 2017, Determining cell fate specification and genetic contribution to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution, http://dx.doi.org/10.1101/229336
    Preprints | 2017
    Nguyen QH; Lukowski SW; Chiu HS; Senabouth A; Bruxner TJC; Christ AN; Palpant NJ; Powell JE, 2017, Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations, http://dx.doi.org/10.1101/119255
    Preprints | 2017
    Senabouth A; Lukowski SW; Alquicira Hernandez J; Andersen S; Mei X; Nguyen QH; Powell JE, 2017, ascend: R package for analysis of single cell RNA-seq data, http://dx.doi.org/10.1101/207704
    Preprints | 2017
    Wong ES; Chenoweth S; Blows M; Powell JE, 2017, Evidence for stabilizing selection at pleiotropic loci for human complex traits, http://dx.doi.org/10.1101/126888
    Preprints | 2017
    Zeng J; de Vlaming R; Wu Y; Robinson MR; Lloyd-Jones L; Yengo L; Yap C; Xue A; Sidorenko J; McRae AF; Powell JE; Montgomery GW; Metspalu A; Esko T; Gibson G; Wray NR; Visscher PM; Yang J, 2017, Widespread signatures of negative selection in the genetic architecture of human complex traits, http://dx.doi.org/10.1101/145755
    Preprints | 2016
    Hung SSC; Chrysostomou V; Li F; Lim JKH; Wang J-H; Powell JE; Tu L; Daniszewski M; Lo C; Wong RC; Crowston JG; Pébay A; King AE; Bui BV; Liu G-S; Hewitt AW, 2016, AAV-mediated CRISPR/Cas gene editing of retinal cellsin vivo, http://dx.doi.org/10.1101/039156
    Preprints | 2016
    Zeng B; Lloyd-Jones LR; Holloway A; Marigorta UM; Metspalu A; Montgomery GW; Esko T; Brigham KL; Quyyumi AA; Idaghdour Y; Yang J; Visscher PM; Powell JE; Gibson G, 2016, Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression, http://dx.doi.org/10.1101/084293
    Preprints |
    Daniszewski M; Nguyen Q; Chy H; Singh V; Crombie D; Kulkarni T; Liang H; Lidgerwood G; Hernnndez D; Conquest A; Rooney L; Chevalier S; Andersen S; Senabouth A; Vickers J; Mackey D; Craig J; Laslett A; Hewitt A; Powell JE; PPbay A, Single Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media, http://dx.doi.org/10.2139/ssrn.3188388
    Preprints |
    Friedman CE; Nguyen Q; Lukowski SW; Helfer A; Chiu HS; Voges HK; Suo Suo S; Jackie Han J-D; Osteil P; Peng G; Jing N; Baillie GJ; Senabouth A; Christ AN; Bruxner TJ; Murry CE; Wong ES; Ding J; Wang Y; Hudson J; Bar-Joseph Z; Tam PPL; Powell JE; Palpant NJ, Cardiac Directed Differentiation Using Small Molecule WNT Modulation at Single-Cell Resolution, http://dx.doi.org/10.2139/ssrn.3155757
    Preprints |
    Tuong ZK; Lukowski SW; Nguyen QH; Chandra J; Zhou C; Gillinder K; Bashaw AA; Ferdinand JR; Stewart BJ; Teoh SM; Hanson SJ; Devitt K; Clatworthy MR; Powell JE; Frazer IH, A Model of Impaired Langerhans Cell Maturation Associated With HPV Induced Epithelial Hyperplasia, http://dx.doi.org/10.2139/ssrn.3889711