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Dr Josephine Yu

Dr Josephine Yu

Conjoint Lecturer

PhD (Pharmacology and Physiology), UNSW Sydney - 2021

BSc (Hons 1), UNSW Sydney - 2017

Medicine & Health
School of Biomedical Sciences

I am a Research Fellow in the Musculoskeletal Health Program, at The George Institute for Global Health and a conjoint lecturer with SBMS. I was awarded my PhD from UNSW in 2021. My primary research focus is the role of exercise and supplements in enhancing exercise outcomes in disease models. My previous work investigated the potential synergism of exercise and novel supplements in obesity, type 2 diabetes and metabolic disease. 

I am passionate about teaching and supervision. Currently, I am particularly interested in exploring novel interventions (surgical, pharmacological and lifestyle) for musculoskeletal conditions to improve patient outcomes and quality of life.
E-mail
jyu2@georgeinstitute.org.au
Location
The George Institute for Global Health
  • Journal articles | 2024
    Elangovan H; Stokes RA; Keane J; Chahal S; Samer C; Agoncillo M; Yu J; Chen J; Downes M; Evans RM; Liddle C; Gunton JE, 2024, 'Vitamin D Receptor Regulates Liver Regeneration After Partial Hepatectomy in Male Mice', Endocrinology (United States), 165, http://dx.doi.org/10.1210/endocr/bqae077
    Journal articles | 2024
    Yu J; Lalwani A; Gunton JE, 2024, 'β-Cell Deletion of Hypoxia-Inducible Factor 1α (HIF-1α) Increases Pancreatic β-Cell Susceptibility to Streptozotocin', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms252413451
    Journal articles | 2024
    Yu J; Youngson NA; Laybutt DR; Morris MJ; Leigh SJ, 2024, 'Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity', Physiological Genomics, 56, pp. 136 - 144, http://dx.doi.org/10.1152/physiolgenomics.00066.2023
    Journal articles | 2023
    Agoncillo M; Yu J; Gunton JE, 2023, 'The Role of Vitamin D in Skeletal Muscle Repair and Regeneration in Animal Models and Humans: A Systematic Review', Nutrients, 15, http://dx.doi.org/10.3390/nu15204377
    Journal articles | 2022
    Klugmann M; Kalotay E; Delerue F; Ittner LM; Bongers A; Yu J; Morris MJ; Housley GD; Fröhlich D, 2022, 'Correction to: Developmental delay and late onset HBSL pathology in hypomorphic Dars1 M256L mice (Neurochemical Research, (2022), 47, 7, (1972-1984), 10.1007/s11064-022-03582-4)', Neurochemical Research, 47, pp. 1985 - 1990, http://dx.doi.org/10.1007/s11064-022-03602-3
    Journal articles | 2022
    Klugmann M; Kalotay E; Delerue F; Ittner LM; Bongers A; Yu J; Morris MJ; Housley GD; Fröhlich D, 2022, 'Developmental delay and late onset HBSL pathology in hypomorphic Dars1 M256L mice', Neurochemical Research, 47, pp. 1972 - 1984, http://dx.doi.org/10.1007/s11064-022-03582-4
    Journal articles | 2022
    Yu J; Laybutt DR; Youngson NA; Morris MJ, 2022, 'Concurrent betaine administration enhances exercise-induced improvements to glucose handling in obese mice', Nutrition, Metabolism and Cardiovascular Diseases, 32, pp. 2439 - 2449, http://dx.doi.org/10.1016/j.numecd.2022.08.012
    Journal articles | 2022
    Yu J; Sharma P; Girgis CM; Gunton JE, 2022, 'Vitamin D and Beta Cells in Type 1 Diabetes: A Systematic Review', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms232214434
    Journal articles | 2021
    Yu J; Laybutt DR; Kim LJ; Quek LE; Wu LE; Morris MJ; Youngson NA, 2021, 'Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide', American Journal of Physiology - Endocrinology and Metabolism, 321, pp. E176 - E189, http://dx.doi.org/10.1152/AJPENDO.00446.2020
    Journal articles | 2020
    Yu J; Laybutt DR; Kim L-J; Quek L-E; Wu LE; Morris MJ; Youngson NA, 2020, 'EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE', , pp. 2020.06.22.164459, http://dx.doi.org/10.1101/2020.06.22.164459
    Journal articles | 2019
    Montgomery MK; Osborne B; Brandon AE; O'Reilly L; Fiveash CE; Brown SHJ; Wilkins BP; Samsudeen A; Yu J; Devanapalli B; Hertzog A; Tolun AA; Kavanagh T; Cooper AA; Mitchell TW; Biden TJ; Smith NJ; Cooney GJ; Turner N, 2019, 'Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84', FASEB Journal, 33, pp. 12264 - 12276, http://dx.doi.org/10.1096/fj.201900234R
    Journal articles | 2019
    Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574
  • Conference Abstracts | 2019
    Yu J; Morris MJ; Youngson NA, 2019, 'Do exercise and NMN provide synergistic benefits in obese mice?', in Obesity Research & Clinical Practice, Elsevier BV, Vol. 13, pp. 299 - 299, http://dx.doi.org/10.1016/j.orcp.2018.11.182

Best Oral Presentation Winner, Seoul International Congress on Endocrinology and Metabolism - 2024

PIncus-Taft Young Investigator Award, Australasian Diabetes Congress - 2023

Australian Government Research Training Program Scholarship - 2018

Osteoarthritis and musculoskeletal diseases are major public health concerns, causing pain, disability, and high healthcare costs. Exercise is a proven intervention to improve symptoms and function, but patient adherence is low due to discomfort and lack of motivation. My research focuses on developing novel therapeutic strategies to enhance exercise outcomes, making it easier and more effective for patients to manage their condition.