Dr Joshua Hamey
Postdoctoral Fellow

Dr Joshua Hamey

Science
School of Biotech & Biomolecular Science

Joshua Hamey is a post-doctoral Research Associate in the School of Biotechnology and Biomolecular Sciences in the group of Professor Marc Wilkins. His research focuses on understanding proteins and their post-translational modifications, particularly through use of mass spectrometry.

  • Journal articles | 2022
    Bartolec TK; Hamey JJ; Keller A; Chavez JD; Bruce JE; Wilkins MR, 2022, 'Differential proteome and interactome analysis reveal the basis of pleiotropy associated with the histidine methyltransferase Hpm1p.', Mol Cell Proteomics, pp. 100249, http://dx.doi.org/10.1016/j.mcpro.2022.100249
    Journal articles | 2022
    Separovich RJ; Wong MWM; Bartolec TK; Hamey JJ; Wilkins MR, 2022, 'Site-specific Phosphorylation of Histone H3K36 Methyltransferase Set2p and Demethylase Jhd1p is Required for Stress Responses in Saccharomyces cerevisiae', Journal of Molecular Biology, vol. 434, pp. 167500, http://dx.doi.org/10.1016/j.jmb.2022.167500
    Journal articles | 2022
    Tay AP; Hamey JJ; Martyn GE; Wilson LOW; Wilkins MR, 2022, 'Identification of Protein Isoforms Using Reference Databases Built from Long and Short Read RNA-Sequencing.', J Proteome Res, http://dx.doi.org/10.1021/acs.jproteome.1c00968
    Journal articles | 2021
    Emery-Corbin SJ; Hamey JJ; Balan B; Rojas-López L; Svärd SG; Jex AR, 2021, 'Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry', International Journal for Parasitology, vol. 51, pp. 225 - 239, http://dx.doi.org/10.1016/j.ijpara.2020.09.006
    Journal articles | 2021
    Hamey JJ; Nguyen A; Wilkins MR, 2021, 'Discovery of Arginine Methylation, Phosphorylation, and Their Co-occurrence in Condensate-Associated Proteins in Saccharomyces cerevisiae', Journal of Proteome Research, vol. 20, pp. 2420 - 2434, http://dx.doi.org/10.1021/acs.jproteome.0c00927
    Journal articles | 2021
    Hamey JJ; Rakow S; Bouchard C; Senst JM; Kolb P; Bauer UM; Wilkins MR; Hart-Smith G, 2021, 'Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues', FEBS Journal, vol. 288, pp. 5668 - 5691, http://dx.doi.org/10.1111/febs.15837
    Journal articles | 2021
    Separovich RJ; Wong MWM; Chapman TR; Slavich E; Hamey JJ; Wilkins MR, 2021, 'Post-translational modification analysis of Saccharomyces cerevisiae histone methylation enzymes reveals phosphorylation sites of regulatory potential', Journal of Biological Chemistry, vol. 296, http://dx.doi.org/10.1074/JBC.RA120.015995
    Journal articles | 2020
    Bartolec TK; Smith DL; Pang CNI; Xu YD; Hamey JJ; Wilkins MR, 2020, 'Cross-linking Mass Spectrometry Analysis of the Yeast Nucleus Reveals Extensive Protein-Protein Interactions Not Detected by Systematic Two-Hybrid or Affinity Purification-Mass Spectrometry', Analytical Chemistry, vol. 92, pp. 1874 - 1882, http://dx.doi.org/10.1021/acs.analchem.9b03975
    Journal articles | 2020
    Emery-Corbin SJ; Hamey JJ; Ansell BRE; Balan B; Tichkule S; Stroehlein AJ; Cooper C; McInerney BV; Hediyeh-Zadeh S; Vuong D; Crombie A; Lacey E; Davis MJ; Wilkins MR; Bahlo M; Svard SG; Gasser RB; Jex AR, 2020, 'Eukaryote-conserved methylarginine is absent in diplomonads and functionally compensated in Giardia', Molecular Biology and Evolution, vol. 37, pp. 3525 - 3549, http://dx.doi.org/10.1093/molbev/msaa186
    Journal articles | 2020
    Pang CNI; Ballouz S; Weissberger D; Thibaut LM; Hamey JJ; Gillis J; Wilkins MR; Hart-Smith G, 2020, 'Analytical Guidelines for co-fractionation Mass Spectrometry Obtained through Global Profiling of Gold Standard Saccharomyces cerevisiae Protein Complexes', Molecular and Cellular Proteomics, vol. 19, pp. 1876 - 1895, http://dx.doi.org/10.1074/mcp.RA120.002154
    Journal articles | 2020
    Separovich RJ; Wong MWM; Chapman TR; Slavich E; Hamey JJ; Wilkins MR, 2020, 'Post-translational modification analysis of Saccharomyces cerevisiae histone methylation enzymes reveals phosphorylation sites of regulatory potential.', J Biol Chem, pp. 100192, http://dx.doi.org/10.1074/jbc.RA120.015995
    Journal articles | 2020
    Smith DL; Erce MA; Lai YW; Tomasetig F; Hart-Smith G; Hamey JJ; Wilkins MR, 2020, 'Crosstalk of Phosphorylation and Arginine Methylation in Disordered SRGG Repeats of Saccharomyces cerevisiae Fibrillarin and Its Association with Nucleolar Localization', Journal of Molecular Biology, vol. 432, pp. 448 - 466, http://dx.doi.org/10.1016/j.jmb.2019.11.006
    Journal articles | 2019
    Lowe BR; Maxham LA; Hamey JJ; Wilkins MR; Partridge JF, 2019, 'Histone H3 mutations: An updated view of their role in chromatin deregulation and cancer', Cancers, vol. 11, pp. 1 - 24, http://dx.doi.org/10.3390/cancers11050660
    Journal articles | 2019
    Tay AP; Liang A; Hamey JJ; Hart-Smith G; Wilkins MR, 2019, 'MS2-Deisotoper: A Tool for Deisotoping High-Resolution MS/MS Spectra in Normal and Heavy Isotope-Labelled Samples', Proteomics, vol. 19, http://dx.doi.org/10.1002/pmic.201800444
    Journal articles | 2018
    Chia SZ; Lai YW; Yagoub D; Lev S; Hamey JJ; Ignatius Pang CN; Desmarini D; Chen Z; Djordjevic JT; Erce MA; Hart-Smith G; Wilkins MR, 2018, 'Knockout of the Hmt1p arginine methyltransferase in saccharomyces cerevisiae leads to the dysregulation of phosphate-associated genes and processes', Molecular and Cellular Proteomics, vol. 17, pp. 2462 - 2479, http://dx.doi.org/10.1074/mcp.RA117.000214
    Journal articles | 2018
    Hamey JJ; Separovich RJ; Wilkins MR, 2018, 'MT-MAMS: Protein Methyltransferase Motif Analysis by Mass Spectrometry', Journal of Proteome Research, vol. 17, pp. 3485 - 3491, http://dx.doi.org/10.1021/acs.jproteome.8b00396
    Journal articles | 2018
    Hamey JJ; Wilkins MR, 2018, 'Methylation of Elongation Factor 1A: Where, Who, and Why?', Trends in Biochemical Sciences, vol. 43, pp. 211 - 223, http://dx.doi.org/10.1016/j.tibs.2018.01.004
    Journal articles | 2017
    Hamey JJ; Wienert B; Quinlan KGR; Wilkins MR, 2017, 'METTL21B Is a Novel Human lysine methyltransferase of translation elongation factor 1A: Discovery by CRISPR/Cas9 Knockout', Molecular and Cellular Proteomics, vol. 16, pp. 2229 - 2242, http://dx.doi.org/10.1074/mcp.M116.066308
    Journal articles | 2016
    Hamey JJ; Hart-Smith G; Erce MA; Wilkins MR, 2016, 'The activity of a yeast Family 16 methyltransferase, Efm2, is affected by a conserved tryptophan and its N-terminal region', FEBS Open Bio, vol. 6, pp. 1320 - 1330, http://dx.doi.org/10.1002/2211-5463.12153
    Journal articles | 2016
    Hamey JJ; Winter DL; Yagoub D; Overall CM; Hart-Smith G; Wilkins MR, 2016, 'Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human', Molecular and Cellular Proteomics, vol. 15, pp. 164 - 176, http://dx.doi.org/10.1074/mcp.M115.052449
    Journal articles | 2015
    Yagoub D; Tay AP; Chen Z; Hamey JJ; Cai C; Chia SZ; Hart-Smith G; Wilkins MR, 2015, 'Proteogenomic Discovery of a Small, Novel Protein in Yeast Reveals a Strategy for the Detection of Unannotated Short Open Reading Frames', Journal of Proteome Research, vol. 14, pp. 5038 - 5047, http://dx.doi.org/10.1021/acs.jproteome.5b00734
    Journal articles | 2014
    Zhang L; Hamey JJ; Hart-Smith G; Erce MA; Wilkins MR, 2014, 'Elongation factor methyltransferase 3 - A novel eukaryotic lysine methyltransferase', Biochemical and Biophysical Research Communications, vol. 451, pp. 229 - 234, http://dx.doi.org/10.1016/j.bbrc.2014.07.110