Associate Professor Kate   Poole
Associate Professor

Associate Professor Kate Poole

medicine-health
School of Medical Sciences

Dr Kate Poole received her PhD from the University of Adelaide in 2002 before moving to Germany to undertake postdoctoral studies. Whilst in Germany Kate worked at the Max Planck Institute for Molecular Cell Biology and Genetics and the Technische Universitaet Dresden. Kate then spent a couple of years working in industry for the atomic force microscopy company JPK Instruments, AG. In 2008 Kate returned to science, taking a postdoctoral position at the Max Delbruck Center for Molecular Medicine. In 2012, Kate received the Cecile Vogt Fellowship which allowed her to establish her research independance, also at the Max Delbruck Center. Kate has recently returned from Germany to join the Department of Physiology, School of Medical Sciences, as a lecturer. Her research interests revolve around understanding how cells sense their physical environment.

The sensing of and discrimination between different physical inputs is critical in the function of many cells and tissues in multicellular organisms; an acute response to mechanical stimuli underpins our senses of touch and hearing, integrated sensing of changing mechanical loads is fundamental for maintaining cartilage and the vasculature, and migratory cells (such as fibroblasts in wound healing or tumour cells during metastasis) can probe the mechanical properties of their surroundings by applying forces at cell-matrix contact points. Kate is studying the molecular mechanisms of cellular sensing of physical stimuli across a number of mammalian systems: in touch sensation in the somatic sensory system, the homeostatic maintenance of cartilage and in melanoma progression and metastasis.

Phone
93851764

Publications

  • Book Chapters | 2011
    Associate Professor Kate Poole
    Poole K; Moroni M; Lewin GR, 2011, 'The Molecular and Genetic Basis of Touch', in The Handbook of Touch Neuroscience, Behavioral, and Health Perspectives, Springer Publishing Company
    Book Chapters | 2007
    Associate Professor Kate Poole
    Ludwig T; Kirmse R; Poole K, 2007, 'Challenges and Approaches - Probing Tumor Cell Invasion by Atomic Force Microscopy.', in Mendez-Vilas A; Diaz J (ed.), Modern research and educational topics in microscopy no. III. vol I, Formatex, Spain, pp. 11 - 11
  • Journal articles | 2021
    Associate Professor Kate Poole
    Molley TG; Jalandhra GK; Nemec SR; Tiffany AS; Patkunarajah A; Poole K; Harley BAC; Hung TT; Kilian KA, 2021, 'Heterotypic tumor models through freeform printing into photostabilized granular microgels', Biomaterials Science, vol. 9, pp. 4496 - 4509, http://dx.doi.org/10.1039/d1bm00574j
    Journal articles | 2021
    Associate Professor Kate Poole
    Richardson J; Kotevski A; Poole K, 2021, 'From stretch to deflection: the importance of context in the activation of mammalian, mechanically activated ion channels', FEBS Journal, http://dx.doi.org/10.1111/febs.16041
    Journal articles | 2021
    Associate Professor Kate Poole
    Sianati S; Schroeter L; Richardson J; Tay A; Lamandé SR; Poole K, 2021, 'Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface', Frontiers in Bioengineering and Biotechnology, vol. 8, pp. 608951, http://dx.doi.org/10.3389/fbioe.2020.608951
    Journal articles | 2021
    Associate Professor Kate Poole
    Patkunarajah A; Schroeter L; Sanderson G; Biro M; Poole K, 2021, 'Disrupting ELKIN1-Dependent Mechanoelectrical Transduction Modulates Cell-Cell Interactions in Organotypic Tumour Spheroids', Biophysical Journal, vol. 120, pp. 65a - 66a, http://dx.doi.org/10.1016/j.bpj.2020.11.624
    Journal articles | 2020
    Associate Professor Kate Poole
    Bradbury P; Wu H; Choi JU; Rowan AE; Zhang H; Poole K; Lauko J; Chou J, 2020, 'Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease', Frontiers in Cell and Developmental Biology, vol. 8, pp. 96, http://dx.doi.org/10.3389/fcell.2020.00096
    Journal articles | 2020
    Associate Professor Kate Poole
    Patkunarajah A; Stear JH; Moroni M; Schroeter L; Blaszkiewicz J; Tearle JLE; Cox CD; Fuerst C; Sánchez-Carranza O; Fernández MDÁO; Fleischer R; Eravci M; Weise C; Martinac B; Biro M; Lewin GR; Poole K, 2020, 'TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.', eLife, vol. 9, http://dx.doi.org/10.7554/eLife.53308
    Journal articles | 2020
    Associate Professor Kate Poole
    Beaulieu-Laroche L; Christin M; Donoghue A; Agosti F; Yousefpour N; Petitjean H; Davidova A; Stanton C; Khan U; Dietz C; Faure E; Fatima T; MacPherson A; Mouchbahani-Constance S; Bisson DG; Haglund L; Ouellet JA; Stone LS; Samson J; Smith MJ; Ask K; Ribeiro-da-Silva A; Blunck R; Poole K; Bourinet E; Sharif-Naeini R, 2020, 'TACAN Is an Ion Channel Involved in Sensing Mechanical Pain', Cell, vol. 180, pp. 956 - 967.e17, http://dx.doi.org/10.1016/j.cell.2020.01.033
    Journal articles | 2020
    Associate Professor Kate Poole
    Servin-Vences MR; Poole K; Sporbert A; Lewin GR; Margineanu A, 2020, 'Collagen Organization Within the Cartilage of Trpv4−/− Mice Studied with Two-Photon Microscopy and Polarized Second Harmonic Generation', Cytometry Part A, vol. 97, pp. 504 - 514, http://dx.doi.org/10.1002/cyto.a.23900
    Journal articles | 2020
    Associate Professor Kate Poole
    Putra VDL; Song MJ; McBride-Gagyi S; Chang H; Poole K; Whan R; Dean D; Sansalone V; Knothe Tate ML, 2020, 'Mechanomics Approaches to Understand Cell Behavior in Context of Tissue Neogenesis, During Prenatal Development and Postnatal Healing', Frontiers in Cell and Developmental Biology, vol. 7, http://dx.doi.org/10.3389/fcell.2019.00354
    Journal articles | 2019
    Associate Professor Kate Poole
    Putra VDL; Jalilian I; Campbell M; Poole K; Whan R; Tomasetig F; Tate MLK, 2019, 'Mapping the Mechanome-A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression.', Bio Protoc, vol. 9, pp. e3439, http://dx.doi.org/10.21769/BioProtoc.3439
    Journal articles | 2019
    Associate Professor Kate Poole
    Bavi N; Richardson J; Heu C; Martinac B; Poole K, 2019, 'PIEZO1-Mediated Currents Are Modulated by Substrate Mechanics', ACS Nano, vol. 13, pp. 13545 - 13559, http://dx.doi.org/10.1021/acsnano.9b07499
    Journal articles | 2019
    Associate Professor Kate Poole
    Sianati S; Kurumlian A; Bailey E; Poole K, 2019, 'Analysis of mechanically activated ion channels at the cell-substrate interface: Combining pillar arrays and whole-cell patch-clamp', Frontiers in Bioengineering and Biotechnology, vol. 7, http://dx.doi.org/10.3389/fbioe.2019.00047
    Journal articles | 2018
    Associate Professor Kate Poole
    Martinac B; Poole K, 2018, 'Mechanically activated ion channels', International Journal of Biochemistry and Cell Biology, vol. 97, pp. 104 - 107, http://dx.doi.org/10.1016/j.biocel.2018.02.011
    Journal articles | 2018
    Associate Professor Kate Poole
    Servin-Vences MR; Richardson J; Lewin GR; Poole K, 2018, 'Mechanoelectrical transduction in chondrocytes', Clinical and Experimental Pharmacology and Physiology, vol. 45, pp. 481 - 488, http://dx.doi.org/10.1111/1440-1681.12917
    Journal articles | 2018
    Associate Professor Kate Poole
    Tay A; Sohrabi A; Poole K; Seidlits S; Di Carlo D, 2018, 'A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons', Advanced Materials, vol. 30, http://dx.doi.org/10.1002/adma.201800927
    Journal articles | 2017
    Associate Professor Kate Poole
    Ma Y; Poole K; Goyette J; Gaus K, 2017, 'Introducing membrane charge and membrane potential to T cell signaling', Frontiers in Immunology, vol. 8, http://dx.doi.org/10.3389/fimmu.2017.01513
    Journal articles | 2017
    Associate Professor Kate Poole
    Servin-Vences MR; Moroni M; Lewin GR; Poole K, 2017, 'Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes', eLife, vol. 6, http://dx.doi.org/10.7554/eLife.21074
    Journal articles | 2017
    Associate Professor Kate Poole
    Wetzel C; Pifferi S; Picci C; Gök C; Hoffmann D; Bali KK; Lampe A; Lapatsina L; Fleischer R; Smith ESJ; Bégay V; Moroni M; Estebanez L; Kühnemund J; Walcher J; Specker E; Neuenschwander M; Von Kries JP; Haucke V; Kuner R; Poulet JFA; Schmoranzer J; Poole K; Lewin GR, 2017, 'Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity', Nature Neuroscience, vol. 20, pp. 209 - 218, http://dx.doi.org/10.1038/nn.4454
    Journal articles | 2016
    Associate Professor Kate Poole
    Grandin M; Meier M; Delcros JG; Nikodemus D; Reuten R; Patel TR; Goldschneider D; Orriss G; Krahn N; Boussouar A; Abes R; Dean Y; Neves D; Bernet A; Depil S; Schneiders F; Poole K; Dante R; Koch M; Mehlen P; Stetefeld J, 2016, 'Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers', Cancer Cell, vol. 29, pp. 173 - 185, http://dx.doi.org/10.1016/j.ccell.2016.01.001
    Journal articles | 2015
    Associate Professor Kate Poole
    Poole K; Moroni M; Lewin GR, 2015, 'Sensory mechanotransduction at membrane-matrix interfaces', Pflugers Archiv European Journal of Physiology, vol. 467, pp. 121 - 132, http://dx.doi.org/10.1007/s00424-014-1563-6
    Journal articles | 2014
    Associate Professor Kate Poole
    Poole K; Herget R; Lapatsina L; Ngo HD; Lewin GR, 2014, 'Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms4520
    Journal articles | 2012
    Associate Professor Kate Poole
    Long D; Wilkinson KL; Poole K; Taylor DK; Warren T; Astorga AM; Jiranek V, 2012, 'Rapid method for proline determination in grape juice and wine', Journal of Agricultural and Food Chemistry, vol. 60, pp. 4259 - 4264, http://dx.doi.org/10.1021/jf300403b
    Journal articles | 2012
    Associate Professor Kate Poole
    Lapatsina L; Jira JA; Smith ESJ; Poole K; Kozlenkov A; Bilbao D; Lewin GR; Heppenstall PA, 2012, 'Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons', Open Biology, vol. 2, http://dx.doi.org/10.1098/rsob.120096
    Journal articles | 2012
    Associate Professor Kate Poole
    Brand J; Smith ESJ; Schwefel D; Lapatsina L; Poole K; Omerbašić D; Kozlenkov A; Behlke J; Lewin GR; Daumke O, 2012, 'A stomatin dimer modulates the activity of acid-sensing ion channels', EMBO Journal, vol. 31, pp. 3635 - 3646, http://dx.doi.org/10.1038/emboj.2012.203
    Journal articles | 2012
    Associate Professor Kate Poole
    Lapatsina L; Brand J; Poole K; Daumke O; Lewin GR, 2012, 'Stomatin-domain proteins', European Journal of Cell Biology, vol. 91, pp. 240 - 245, http://dx.doi.org/10.1016/j.ejcb.2011.01.018
    Journal articles | 2011
    Associate Professor Kate Poole
    Lechner SG; Markworth S; Poole K; Smith ESJ; Lapatsina L; Frahm S; May M; Pischke S; Suzuki M; Ibañez-Tallon I; Luft FC; Jordan J; Lewin GR, 2011, 'The molecular and cellular identity of peripheral osmoreceptors', Neuron, vol. 69, pp. 332 - 344, http://dx.doi.org/10.1016/j.neuron.2010.12.028
    Journal articles | 2011
    Associate Professor Kate Poole
    Chiang LY; Poole K; Oliveira BE; Duarte N; Sierra YAB; Bruckner-Tuderman L; Koch M; Hu J; Lewin GR, 2011, 'Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons', Nature Neuroscience, vol. 14, pp. 993 - 1000, http://dx.doi.org/10.1038/nn.2873
    Journal articles | 2009
    Associate Professor Kate Poole
    Poole K; Walker ME; Warren T; Gardner J; McBryde C; Lopes MDB; Jiranek V, 2009, 'Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast', Journal of General and Applied Microbiology, vol. 55, pp. 427 - 439, http://dx.doi.org/10.2323/jgam.55.427
    Journal articles | 2008
    Associate Professor Kate Poole
    Ludwig T; Kirmse R; Poole K; Schwarz US, 2008, 'Probing cellular microenvironments and tissue remodeling by atomic force microscopy', Pflugers Archiv European Journal of Physiology, vol. 456, pp. 29 - 49, http://dx.doi.org/10.1007/s00424-007-0398-9
    Journal articles | 2008
    Associate Professor Kate Poole
    Balzar M; Poole K, 2008, 'Confocal and Atomic Force Microscopy', Imaging & Microscopy, vol. 10, pp. 56 - 57, http://dx.doi.org/10.1002/imic.200890049
    Journal articles | 2006
    Associate Professor Kate Poole
    Puech PH; Poole K; Knebel D; Muller DJ, 2006, 'A new technical approach to quantify cell-cell adhesion forces by AFM', Ultramicroscopy, vol. 106, pp. 637 - 644, http://dx.doi.org/10.1016/j.ultramic.2005.08.003
    Journal articles | 2006
    Associate Professor Kate Poole
    Poole K, 2006, 'Two Microscopes, One Software', Imaging & Microscopy, vol. 8, pp. 43 - 44, http://dx.doi.org/10.1002/imic.200790067
    Journal articles | 2005
    Associate Professor Kate Poole
    Poole K; Khairy K; Friedrichs J; Franz C; Cisneros DA; Howard J; Mueller D; Baumeister W, 2005, 'Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces', Journal of Molecular Biology, vol. 349, pp. 380 - 386, http://dx.doi.org/10.1016/j.jmb.2005.03.064
    Journal articles | 2005
    Associate Professor Kate Poole
    Poole K; Müller D, 2005, 'Flexible, actin-based ridges colocalise with the β1 integrin on the surface of melanoma cells', British Journal of Cancer, vol. 92, pp. 1499 - 1505, http://dx.doi.org/10.1038/sj.bjc.6602515
    Journal articles | 2005
    Associate Professor Kate Poole
    Poole K; Müller DJ, 2005, 'Connections between surface structure and functional state of cell membrane of cancer cells', BioSpektrum, vol. 11, pp. 465 - 466
    Journal articles | 2004
    Associate Professor Kate Poole
    Poole K; Meder D; Simons K; Müller D, 2004, 'The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy', FEBS Letters, vol. 565, pp. 53 - 58, http://dx.doi.org/10.1016/j.febslet.2004.03.095
    Journal articles | 2004
    Associate Professor Kate Poole
    Jiang F; Khairy K; Poole K; Howard J; Müller DJ, 2004, 'Creating nanoscopic collagen matrices using atomic force microscopy', Microscopy Research and Technique, vol. 64, pp. 435 - 440, http://dx.doi.org/10.1002/jemt.20101
    Journal articles | 2002
    Associate Professor Kate Poole
    Gardner JM; Poole K; Jiranek V, 2002, 'Practical significance of relative assimilable nitrogen requirements of yeast: A preliminary study of fermentation performance and liberation of H2S', Australian Journal of Grape and Wine Research, vol. 8, pp. 175 - 179, http://dx.doi.org/10.1111/j.1755-0238.2002.tb00253.x
  • Conference Abstracts | 2020
    Associate Professor Kate Poole
    Richardson J; Sianati S; Bavi N; Schroeter L; Patkunarajah A; Poole K, 2020, 'From Stretch to Deflection: Fine Tuning Mechanical Activation of ion Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, Vol. 118, pp. 171A - 171A, presented at 64th Annual Meeting of the Biophysical-Society, San Diego, CA, 15 February 2020 - 19 February 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000513023201104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Associate Professor Kate Poole
    Bavi N; Richardson J; Poole K, 2018, 'Cellular Mechanotransduction via Ion Channels at the Cell-Substrate Interface', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, pp. 19A - 19A, presented at 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, 17 February 2018 - 21 February 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429315800102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2016
    Associate Professor Kate Poole
    Poole K; Wetzel C; Stear JH; Moroni M; Lewin GR, 2016, 'Tuning PIEZO ion channels to detect molecular-scale movements relevant for fine touch', presented at ComBIO, Brisbane, 03 October 2016 - 07 October 2016
    Conference Papers | 2011
    Associate Professor Kate Poole
    Poole K; Lewin G, 2011, 'Defining the forces required to gate mechanosensitive channels in mammalian sensory neurons', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, Budapest, HUNGARY, pp. 231 - 231, presented at 8th EBSA European Biophysics Congress, Budapest, HUNGARY, 23 August 2011 - 27 August 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293637300660&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2007
    Associate Professor Kate Poole
    Poole K; Behme G; Haschke H; Owen R, 2007, 'The cellhesion - quantifying adhesion forces between single cells', in European Cells and Materials, pp. 75
    Conference Papers | 2007
    Associate Professor Kate Poole
    Poole K, 2007, 'The CellHesion - quantifying adhesion forces between single cells', in EUROPEAN JOURNAL OF CELL BIOLOGY, ELSEVIER GMBH, URBAN & FISCHER VERLAG, Johann Wolfgang Goethe Univ Frankfurt, Frankfurt, GERMANY, pp. 12 - 12, presented at 30th Annual Meeting of the German-Society-for-Cell-Biology, Johann Wolfgang Goethe Univ Frankfurt, Frankfurt, GERMANY, 14 March 2007 - 17 March 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245214800016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2006
    Associate Professor Kate Poole
    Loebbe C; Poole K; Owen R, 2006, 'Combining advanced force and optical microscopy techniques for biophysics research', in EUROPEAN JOURNAL OF CELL BIOLOGY, ELSEVIER GMBH, URBAN & FISCHER VERLAG, Braunschweig, GERMANY, pp. 42 - 42, presented at 29th Annual Meeting of the German Society for Cell Biology, Braunschweig, GERMANY, 29 March 2006 - 01 April 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237127500080&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Awards

Grants

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