Dr Krystyna Gieniec
Postdoctoral Fellow

Dr Krystyna Gieniec

Medicine & Health
School of Clinical Medicine

Krystyna is a full-time Postdoctoral Fellow in the EMBL-Australia Calcium Signalling lab headed by Dr Felicity Davis ((davis lab (davislabresearch.net). Her research evolves around the mammary gland, where she hopes to discover how the epithelium and its adjacent stroma interact via calcium-induced signals to promote mammary development at both embryonic and cancerous stages. To study this, Krystyna employs the use of genetically modified animal models and complex 3D cell systems coupled with advanced 3D volumetric microscopy imaging.

Location
Room 317, Level 3, Lowy Building
  • Journal articles | 2022
    Dhakal B; Li CMY; Li R; Yeo K; Wright JA; Gieniec KA; Vrbanac L; Sammour T; Lawrence M; Thomas M; Lewis M; Perry J; Worthley DL; Woods SL; Drew P; Sallustio BC; Smith E; Horowitz JD; Maddern GJ; Licari G; Fenix K, 2022, 'The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing', Cancers, vol. 14, http://dx.doi.org/10.3390/cancers14041043
    Journal articles | 2022
    Gieniec KA, 2022, 'Mammary gland architecture under the lens: How visualising tissues in 3D provides deeper insights into structure and function', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1869, http://dx.doi.org/10.1016/j.bbamcr.2022.119283
    Journal articles | 2022
    Gieniec KA, 2022, 'Scope for change', Journal of cell science, vol. 135, http://dx.doi.org/10.1242/jcs.260039
    Journal articles | 2022
    Gieniec KA; Davis FM, 2022, 'Mammary basal cells: Stars of the show', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1869, http://dx.doi.org/10.1016/j.bbamcr.2021.119159
    Journal articles | 2022
    Kobayashi H; Gieniec KA; Lannagan TRM; Wang T; Asai N; Mizutani Y; Iida T; Ando R; Thomas EM; Sakai A; Suzuki N; Ichinose M; Wright JA; Vrbanac L; Ng JQ; Goyne J; Radford G; Lawrence MJ; Sammour T; Hayakawa Y; Klebe S; Shin AE; Asfaha S; Bettington ML; Rieder F; Arpaia N; Danino T; Butler LM; Burt AD; Leedham SJ; Rustgi AK; Mukherjee S; Takahashi M; Wang TC; Enomoto A; Woods SL; Worthley DL, 2022, 'The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis', Gastroenterology, vol. 162, pp. 890 - 906, http://dx.doi.org/10.1053/j.gastro.2021.11.037
    Journal articles | 2021
    Ichinose M; Suzuki N; Wang T; Kobayashi H; Vrbanac L; Ng JQ; Wright JA; Lannagan TRM; Gieniec KA; Lewis M; Ando R; Enomoto A; Koblar S; Thomas P; Worthley DL; Woods SL, 2021, 'The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses', Development (Cambridge), vol. 148, http://dx.doi.org/10.1242/DEV.195883
    Journal articles | 2021
    Ichinose M; Suzuki N; Wang T; Wright JA; Lannagan TRM; Vrbanac L; Kobayashi H; Gieniec K; Ng JQ; Ihara S; Mavrangelos C; Hayakawa Y; Hughes P; Worthley DL; Woods SL, 2021, 'Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma', Scientific Reports, vol. 11, http://dx.doi.org/10.1038/s41598-021-86675-4
    Journal articles | 2021
    Ichinose M; Suzuki N; Wang T; Wright JA; Lannagan TRM; Vrbanac L; Kobayashi H; Gieniec KA; Ng JQ; Hayakawa Y; García-Gallastegui P; Monsalve EM; Bauer SR; Laborda J; García-Ramírez JJ; Ibarretxe G; Worthley DL; Woods SL, 2021, 'Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 320, pp. G506 - G520, http://dx.doi.org/10.1152/AJPGI.00445.2020
    Journal articles | 2021
    Kobayashi H; Gieniec KA; Ng JQ; Goyne J; Lannagan TRM; Thomas EM; Radford G; Wang T; Suzuki N; Ichinose M; Wright JA; Vrbanac L; Burt AD; Takahashi M; Enomoto A; Worthley DL; Woods SL, 2021, 'Portal vein injection of colorectal cancer organoids to study the liver metastasis stroma', Journal of Visualized Experiments, vol. 2021, http://dx.doi.org/10.3791/62630
    Journal articles | 2021
    Kobayashi H; Gieniec KA; Wright JA; Wang T; Asai N; Mizutani Y; Lida T; Ando R; Suzuki N; Lannagan TRM; Ng JQ; Hara A; Shiraki Y; Mii S; Ichinose M; Vrbanac L; Lawrence MJ; Sammour T; Uehara K; Davies G; Lisowski L; Alexander IE; Hayakawa Y; Butler LM; Zannettino ACW; Din MO; Hasty J; Burt AD; Leedham SJ; Rustgi AK; Mukherjee S; Wang TC; Enomoto A; Takahashi M; Worthley DL; Woods SL, 2021, 'The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis', Gastroenterology, vol. 160, pp. 1224 - 1239.e30, http://dx.doi.org/10.1053/j.gastro.2020.11.011
    Journal articles | 2019
    Gieniec KA; Butler LM; Worthley DL; Woods SL, 2019, 'Cancer-associated fibroblasts—heroes or villains?', British Journal of Cancer, vol. 121, pp. 293 - 302, http://dx.doi.org/10.1038/s41416-019-0509-3
    Journal articles | 2019
    Lannagan TRM; Lee YK; Wang T; Roper J; Bettington ML; Fennell L; Vrbanac L; Jonavicius L; Somashekar R; Gieniec K; Yang M; Ng JQ; Suzuki N; Ichinose M; Wright JA; Kobayashi H; Putoczki TL; Hayakawa Y; Leedham SJ; Abud HE; Yilmaz ÖH; Marker J; Klebe S; Wirapati P; Mukherjee S; Tejpar S; Leggett BA; Whitehall VLJ; Worthley DL; Woods SL, 2019, 'Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis', Gut, vol. 68, pp. 684 - 692, http://dx.doi.org/10.1136/gutjnl-2017-315920
    Journal articles | 2017
    Boyle ST; Gieniec KA; Gregor CE; Faulkner JW; McColl SR; Kochetkova M, 2017, 'Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells', Molecular Cancer, vol. 16, http://dx.doi.org/10.1186/s12943-017-0592-0
  • Other | 2022
    Gieniec K, 2022, Scope for Change, http://dx.doi.org/10.1242/focalplane.9245

2021
- 'The Illuminators' virtual microscopy exhibition for UNSW Diversity Fest 2021 (The Illuminators: Scope for Change | Equity Diversity & Inclusion - UNSW Sydney)

2022
- Cover image for BBA Molecular Cell Research
- Postdoctoral Travel Award (SBMS, UNSW)
- Travel Fellowship Award for Junior Researchers (European Calcium Society)
- Drabikowski Award for best talk by an early career researcher and for showing promise as an emerging leader (16th International Meeting of the European Calcium Society)

2021
- Dean's Commendation for Doctoral Thesis Excellence
- People’s Choice Award for Favourite Video in ‘The Illuminators’ microscopy exhibition (as part of Diversity Fest 2021; The Illuminators: Scope for Change | Equity Diversity & Inclusion - UNSW Sydney)
- First place in the Live Cell Imaging Category of the LMA/VIA 2021 Image Competition (LMA and VIA 2021 Image Competition Winners – Live Cell Category – Australian Microscopy and Microanalysis Society)
- Best Image Award for the 2021 ANZSCDB microscopy imaging competition (2021 Image Award — ANZSCDB)

2017-2020
- Lions Medical Research Foundation Inc Supplementary Scholarship
- Research Training Program Stipend

2020
- Basic Science Young Investigator Award finalist (GESA Annual Scientific Meeting)

2019
- Merck Business and Enterprise Prize (13th Annual Florey Postgraduate Conference)

2018
- Adelaide Graduate Centre Research Travel Scholarship

2016
- Jemima Lendrum Honours Grant
- Gastrointestinal Cancer Biology Group Honours Scholarship

2014
- Summer Research Scholarship