Professor Kurosh Parsi
Conjoint Professor

Professor Kurosh Parsi

            Undergraduate Degree

            Bachelor of Medicine, Bachelor of Surgery (MBBS)

The University of Sydney

1993

 

Postgraduate Degrees

Master of Science (Medicine)

Thesis: Travellers’ Venous Thromboembolism

Supervisor: Professor Reginald Lord

Co-supervisors: Dr Michael McGrath, Professor David Ma

 

Departments of Vascular Surgery, Vascular Medicine and Haematology

St. Vincent’s Hospital

University of New South Wales (UNSW)

2001   

 

Ph D

Thesis: Interaction of Detergent Sclerosants with Coagulation, Antithrombotic and Fibrinolytic Mechanisms

Supervisor: Dr Joanne Joseph

Co-supervisors: Professor David Ma, Professor Ken Myers

 

Haematology Research Laboratory

St. Vincent’s Centre for Applied Medical Research

University of New South Wales (UNSW)

2011

 

Master of International Law (LLM)

University of Salford (United Kingdom)

2021

 

            Fellowships

           Australasian College of Phlebology

2000                 FACP (Foundation Fellowship)

 

Australasian College of Dermatologists

              2004               FACD

 

Professional Memberships

  • American Venous Lymphatic Society (AVLS)
  • American Venous Forum (AVF)
  • Asia Pacific Society for Thrombosis and Haemostasis (APSTH)
  • Australian Society for Thrombosis and Haemostasis (ASTH)
  • Australasian Society for Ultrasound in Medicine (ASUM)
  • Australian Vascular Anomalies Network
  • Canadian Society of Phlebology (CSP) 
  • European Society for Vascular Surgery (ESVS)
  • International Society for Fibrinolysis and Proteolysis (ISFP)
  • International Society for the Study of Vascular Anomalies (ISSVA)
  • International Society for Thrombosis and Hemostasis (ISTH)

 

Medicine & Health
School of Clinical Medicine

Professor Kurosh Parsi  MBBS, MSc (Med), PhD, LLM, FACD, FACP is a dermatologist, phlebologist and vascular anomalies specialist. Prof. Parsi is the Head of Department of Dermatology, St. Vincent’s Hospital, Sydney and Program Head, Dermatology, Phlebology and Fluid Mechanics Research Laboratory, St. Vincent’s Centre for Applied Medical Research. He served as Staff Specialist in Dermatology and Vascular Anomalies, Sydney Children’s Hospital for 10 years. Professor Parsi sub-specializes in vascular anomalies and vascular dermatology.

Prof. Parsi is a medical graduate of the University of Sydney (MBBS). He obtained his Master of Science in Medicine (MSc) followed by a PhD in the field of thrombosis, haemostasis and fibrinolysis from the University of New South Wales (UNSW). He then completed a Master of International Law (LLM) from the University of Salford, Manchester.

Prof. Parsi is a conjoint Professor of Medicine at UNSW and has served as an Adjunct Professor of Fluid Mechanics at the University of Sydney, School of Mechanical and Mechatronic Engineering.

Professor Parsi’s basic science research has focused on physico-chemical and fluid mechanics of sclerosant foams and the interaction of detergent sclerosants with coagulation, antithrombotic and fibrinolytic mechanisms. His clinical research in phlebology has focused on deep vein sclerosis and sclerothrombus. His research in dermatology has been on dermatological conditions with a vascular aetiology including pigmented purpuric dermatoses (PPD), vascular malformations and reticulate eruptions.

Professor Parsi served the Australasian College of Phlebology (ACP) as President (2007-2017) and was the convener of the Annual Scientific Meetings (2007-2017) and the World Congress of Phlebology (Melbourne, Australia; 4-8 February 2018).

Prof. Parsi is the President of the International Union of Phlebology (UIP), the international organisation with more than 70 vascular societies (http://www.uip-phlebology.org/). He previously served the UIP as the Vice President (2009-2013), Treasurer (2013-2017) and President-elect (2018-2019).

Phone
+61 2 9386 0211
Location
St Vincent's Clinical School
  • Book Chapters | 2017
    Parsi K, 2017, 'Complications of Endovascular Treatment of Peripheral Congenital Vascular Malformations', in Congenital Vascular Malformations, Springer
    Book Chapters | 2017
    Parsi K, 2017, 'Management of Lymphatic Malformations', in Congenital Vascular Malformations, Springer
    Book Chapters | 2017
    Ugolini-Lopes MR; Criado PR; Parsi K; Kucukkaya RD; Amigo M; Tektonidou M; Andrade D, 2017, 'Treatment of Non-criteria Manifestations in Antiphospholipid Syndrome', in Erkan D; Lockshin M (ed.), Antiphospholipid Syndrome, Springer, pp. 247 - 266, http://dx.doi.org/10.1007/978-3-319-55442-6_13
  • Journal articles | 2022
    Kang M; Yang A; Hannaford P; Connor D; Parsi K, 2022, 'Skin necrosis following sclerotherapy. Part 1: Differential diagnosis based on classification of pathogenic mechanisms', Phlebology, vol. 37, pp. 409 - 424, http://dx.doi.org/10.1177/02683555221088101
    Journal articles | 2022
    Parsi K; Kim B; O’Connor AA; Kadam P; Connor D, 2022, 'Chronic venous disease, platelet and haemostatic abnormalities contribute to the pathogenesis of pigmented purpuric dermatoses', Phlebology, vol. 37, pp. 348 - 360, http://dx.doi.org/10.1177/02683555221075813
    Journal articles | 2021
    De Rosa N; Paddon V; Glanville A; Parsi K, 2021, 'Dermatological Disease in Australian Heart and Lung Transplant Recipients', Dermatology, vol. 237, pp. 629 - 634, http://dx.doi.org/10.1159/000510055
    Journal articles | 2021
    Gracé J; Connor D; Bester L; Rogan C; Parsi K, 2021, 'LIPIODOL reduces the lytic activity of detergent sclerosants in vitro', Phlebology, vol. 36, pp. 771 - 778, http://dx.doi.org/10.1177/02683555211018312
    Journal articles | 2021
    Wong K; Connor DE; Andrade OC; Parsi K, 2021, 'Foam bubble size is significantly influenced by sclerosant concentration for polidocanol but not sodium tetradecyl sulphate', Phlebology, vol. 36, pp. 576 - 587, http://dx.doi.org/10.1177/0268355521995012
    Journal articles | 2020
    Connor DE; Gerbelli J; Chew AN; Cooley-Andrade O; Goonawardhana D; Cheung K; Parsi K, 2020, 'Sirolimus and propranolol inhibit endothelial proliferation while detergent sclerosants induce endothelial activation, microparticle release and apoptosis in vitro', Phlebology, vol. 35, pp. 566 - 575, http://dx.doi.org/10.1177/0268355520913384
    Journal articles | 2020
    Parsi K; Kang M; Yang A; Kossard S, 2020, 'Granuloma formation following cyanoacrylate glue injection in peripheral veins and arteriovenous malformation', Phlebology, vol. 35, pp. 115 - 123, http://dx.doi.org/10.1177/0268355519856756
    Journal articles | 2020
    Parsi K; Panozzo B; Bull A; Yang A; Kang M; Parsi Y; Connor DE, 2020, 'Deep vein sclerosis following sclerotherapy: Ultrasonic and d-dimer criteria', Phlebology, vol. 35, pp. 325 - 336, http://dx.doi.org/10.1177/0268355519873534
    Journal articles | 2020
    Parsi K; Roberts S; Kang M; Benson S; Baker L; Berman I; Bester LJ; Connor DE; Dinnen P; Grace J; Stirling A; Ibrahim N; Lekich C; Lim A; Matar L; Nadkarni S; Paraskevas P; Rogan C; Thibault PK; Thibault S; van Rij A; Yang A, 2020, 'Cyanoacrylate closure for peripheral veins: Consensus document of the Australasian College of Phlebology', Phlebology, vol. 35, pp. 153 - 175, http://dx.doi.org/10.1177/0268355519864755
    Journal articles | 2020
    Parsi K; van Rij AM; Meissner MH; Davies AH; De Maeseneer M; Gloviczki P; Benson S; Bottini O; Manuel Canata V; Dinnen P; Gasparis A; Gianesini S; Huber D; Jenkins D; Lal BK; Kabnick L; Lim A; Marston W; Granados AM; Morrison N; Nicolaides A; Paraskevas P; Patel M; Roberts S; Rogan C; Schul MW; Komlos P; Stirling A; Thibault S; Varghese R; Welch HJ; Wittens CHA, 2020, 'Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS):: A consensus document of the International Union of Phlebology (UIP), Australasian College of Phlebology (ACP), American Vein and Lymphatic Society (AVLS), American Venous Forum (AVF), European College of Phlebology (ECoP), European Venous Forum (EVF), Interventional Radiology Society of Australasia (IRSA), Latin American Venous Forum, Pan-American Society of Phlebology and Lymphology and the Venous Association of India (VAI)', Journal of Vascular Surgery: Venous and Lymphatic Disorders, vol. 8, pp. 706 - 710, http://dx.doi.org/10.1016/j.jvsv.2020.05.002
    Journal articles | 2020
    Parsi K; van Rij AM; Meissner MH; Davies AH; Maeseneer MD; Gloviczki P; Benson S; Bottini O; Canata VM; Dinnen P; Gasparis A; Gianesini S; Huber D; Jenkins D; Lal BK; Kabnick L; Lim A; Marston W; Granados AM; Morrison N; Nicolaides A; Paraskevas P; Patel M; Roberts S; Rogan C; Schul MW; Komlos P; Stirling A; Thibault S; Varghese R; Welch HJ; Wittens CHA, 2020, 'Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS): A consensus document of the International Union of Phlebology (UIP), Australasian College of Phlebology (ACP), American Vein and Lymphatic Society (AVLS), American Venous Forum (AVF), European College of Phlebology (ECoP), European Venous Forum (EVF), Interventional Radiology Society of Australasia (IRSA), Latin American Venous Forum, Pan-American Society of Phlebology and Lymphology and the Venous Association of India (VAI)', Phlebology, vol. 35, pp. 550 - 555, http://dx.doi.org/10.1177/0268355520930884
    Journal articles | 2019
    De Rosa N; Paddon VL; Liu Z; Glanville AR; Parsi K, 2019, 'Nonmelanoma Skin Cancer Frequency and Risk Factors in Australian Heart and Lung Transplant Recipients', JAMA Dermatology, vol. 155, pp. 716 - 719, http://dx.doi.org/10.1001/jamadermatol.2018.4789
    Journal articles | 2019
    Gianesini S; Obi A; Onida S; Baccellieri D; Bissacco D; Borsuk D; Campisi C; Campisi CC; Cavezzi A; Chi YW; Chunga J; Corda D; Crippa A; Davies A; De Maeseneer M; Diaz J; Ferreira J; Gasparis A; Intriago E; Jawien A; Jindal R; Kabnick L; Latorre A; Lee BB; Liew NC; Lurie F; Meissner M; Menegatti E; Molteni M; Morrison N; Mosti G; Narayanan S; Pannier F; Parsi K; Partsch H; Rabe E; Raffetto J; Raymond-Martimbeau P; Rockson S; Rosukhovski D; Santiago FR; Schul A; Schul M; Shaydakov E; Sibilla MG; Tessari L; Tomaselli F; Urbanek T; van Rijn MJ; Wakefield T; Wittens C; Zamboni P; Bottini O, 2019, 'Global guidelines trends and controversies in lower limb venous and lymphatic disease: Narrative literature revision and experts’ opinions following the vWINter international meeting in Phlebology, Lymphology & Aesthetics, 23–25 January 2019', Phlebology, vol. 34, pp. 4 - 66, http://dx.doi.org/10.1177/0268355519870690
    Journal articles | 2019
    Kang M; Hurwitz C; Exner T; Yang A; Connor D; Parsi K, 2019, 'Angioscopy: Direct visualization of chronic venous occlusion, May-Thurner syndrome, and other applications in phlebology', Journal of Vascular Surgery: Venous and Lymphatic Disorders, vol. 7, pp. 870 - 881, http://dx.doi.org/10.1016/j.jvsv.2019.05.008
    Journal articles | 2019
    Parsi K; Kang M; Abbott L, 2019, 'Livedo vasculopathy: Ablation of the affected vessels to prevent recurrent ulcerations', Phlebology, vol. 34, pp. 582 - 597, http://dx.doi.org/10.1177/0268355519825894
    Journal articles | 2018
    Kadam P; Lim J; Paver I; Connor DE; Parsi K, 2018, 'Telangiectatic Matting is Associated with Hypersensitivity and a Bleeding Tendency', European Journal of Vascular and Endovascular Surgery, vol. 55, pp. 554 - 559, http://dx.doi.org/10.1016/j.ejvs.2017.12.013
    Journal articles | 2018
    Star P; Connor DE; Parsi K, 2018, 'Novel developments in foam sclerotherapy: Focus on Varithena® (polidocanol endovenous microfoam) in the management of varicose veins', Phlebology, vol. 33, pp. 150 - 162, http://dx.doi.org/10.1177/0268355516687864
    Journal articles | 2017
    Tan L; Wong K; Connor D; Fakhim B; Behnia M; Parsi K, 2017, 'Generation of sclerosant foams by mechanical methods increases the foam temperature', Phlebology, vol. 32, pp. 501 - 505, http://dx.doi.org/10.1177/0268355516671625
    Journal articles | 2016
    Cooley-Andrade O; Goh WX; Connor DE; Ma DDF; Parsi K, 2016, 'Detergent Sclerosants Stimulate Leukocyte Apoptosis and Oncosis', European Journal of Vascular and Endovascular Surgery, vol. 51, pp. 846 - 856, http://dx.doi.org/10.1016/j.ejvs.2016.03.008
    Journal articles | 2015
    Connor DE; Cooley-Andrade O; Goh WX; Ma DDF; Parsi K, 2015, 'Detergent sclerosants are deactivated and consumed by circulating blood cells', European Journal of Vascular and Endovascular Surgery, vol. 49, pp. 426 - 431, http://dx.doi.org/10.1016/j.ejvs.2014.12.029
    Journal articles | 2015
    Cooley-Andrade O; Connor D; Ma D; Weisel J; Parsi K, 2015, 'Morphological changes in vascular and circulating blood cells following exposure to detergent sclerosants', Phlebology: The Journal of Venous Disease, vol. 31, pp. 177 - 191, http://dx.doi.org/10.1177/0268355515573686
    Journal articles | 2015
    Jones L; Parsi K, 2015, 'Arteries masquerading as varicose veins: A trap for phlebologists', Phlebology, vol. 30, pp. 729 - 735, http://dx.doi.org/10.1177/0268355514543940
    Journal articles | 2015
    Mosti G; De Maeseneer M; Cavezzi A; Parsi K; Morrison N; Nelzen O; Rabe E; Partsch H; Caggiati A; Simka M; Obermayer A; Malouf M; Flour M; Maleti O; Perrin M; Reina L; Kalodiki E; Mannello F; Rerkasem K; Cornu-Thenard A; Chi YW; Soloviy M; Bottini O; Mendyk N; Tessari L; Varghese R; Etcheverry R; Pannier F; Lugli M; Carvallo Lantz AJ; Zamboni P; Zuolo M; Godoy MFG; Godoy JMP; Link DP; Junger M; Scuderi A, 2015, 'Society for vascular surgery and American Venous Forum Guidelines on the management of venous leg ulcers: The point of view of the International Union of Phlebology', International Angiology, vol. 34, pp. 202 - 218
    Journal articles | 2015
    Parsi K, 2015, 'Interaction of detergent sclerosants with cell membranes', Phlebology, vol. 30, pp. 306 - 315, http://dx.doi.org/10.1177/0268355514534648
    Journal articles | 2015
    Wong K; Chen T; Connor DE; Behnia M; Parsi K, 2015, 'Basic physiochemical and rheological properties of detergent sclerosants', Phlebology, vol. 30, pp. 339 - 349, http://dx.doi.org/10.1177/0268355514529271
    Journal articles | 2014
    Cooley-Andrade O; Jothidas A; Goh WX; Connor DE; Parsi K, 2014, 'Low-concentration detergent sclerosants stimulate white blood cells and release proinflammatory and proangiogenic cytokines in vitro', Journal of Vascular Surgery: Venous and Lymphatic Disorders, vol. 2, pp. 433 - 440, http://dx.doi.org/10.1016/j.jvsv.2014.02.005
    Journal articles | 2014
    Kim B; Somia N; Pereira J; Parsi K, 2014, 'Open access sclerotherapy: An alternative technique to treat complex venous malformations', Dermatologic Surgery, vol. 40, pp. 802 - 805, http://dx.doi.org/10.1111/dsu.0000000000000026
    Journal articles | 2014
    Parsi K; O'Connor A; Bester L, 2014, 'Stewart-Bluefarb syndrome: Report of five cases and a review of literature', Phlebology: The Journal of Venous Disease, vol. 30, pp. 505 - 514, http://dx.doi.org/10.1177/0268355514548090
    Journal articles | 2014
    Wong K; Chen T; Connor DE; Behnia M; Parsi K, 2014, 'Computational fluid dynamics of liquid and foam sclerosant injection in a vein model', Applied Mechanics and Materials, vol. 553, pp. 293 - 298, http://dx.doi.org/10.4028/www.scientific.net/AMM.553.293
    Journal articles | 2013
    Cameron E; Chen T; Connor DE; Behnia M; Parsi K, 2013, 'Sclerosant foam structure and stability is strongly influenced by liquid air fraction', European Journal of Vascular and Endovascular Surgery, vol. 46, pp. 488 - 494, http://dx.doi.org/10.1016/j.ejvs.2013.07.013
    Journal articles | 2013
    Connor DE; Exner T; Ma DDF; Joseph JE; Parsi K, 2013, 'Infusion of foam sclerosants results in a distance-dependent procoagulant activity, haemoconcentration and elevation of D-dimer levels.', Phlebology, vol. 29, pp. 1 - 12, http://dx.doi.org/10.1177/0268355513502333
    Journal articles | 2013
    Parsi K; Lekich C, 2013, 'Heterotopic ossification of small saphenous vein and panniculitis ossificans of chronic venous insufficiency presenting with livedo racemosa.', Phlebology, vol. 29, pp. 401 - 406, http://dx.doi.org/10.1177/0268355513495829
    Journal articles | 2013
    Valenzuela GC; Wong K; Connor DE; Behnia M; Parsi K, 2013, 'Foam sclerosants are more stable at lower temperatures', European Journal of Vascular and Endovascular Surgery, vol. 46, pp. 593 - 599, http://dx.doi.org/10.1016/j.ejvs.2013.08.012
    Journal articles | 2012
    Christou E; Parsi K, 2012, 'Non-involuting Congenital Haemangioma of the Eyelid: Successful Treatment with Fluroscopic Ultrasound Guided Sclerotherapy and Surgical Excision', phlebology, vol. 11, pp. 1 - 5, http://dx.doi.org/10.1258/phleb.2012.012116
    Journal articles | 2011
    Parsi K; Exner T; Low J; Fung ma DD; Joseph JE, 2011, 'In vitro effects of detergent sclerosants on clot formation and fibrinolysis', European Journal of Vascular and Endovascular Surgery, vol. 41, pp. 267 - 277, http://dx.doi.org/10.1016/j.ejvs.2010.10.004
    Journal articles | 2010
    Parsi K; Zimmet S; Allegra C; Bergan J; Gasparis AP; Labropoulos N; Lee BB; Malouf GM; Partsch H; Rabe E; Ramelet AA; Schadeck M; Vin F, 2010, 'Phlebology training curriculum. A consensus document of the International Union Of Phlebology (UIP)-2010', International Angiology, vol. 29, pp. 533 - 559
    Journal articles | 2009
    Lee BB; Bergan J; Gloviczki R; Laredo J; Loose DA; Mattassi R; Parsi K; Villavicencio JL; Zamboni P, 2009, 'Diagnosis and treatment of venous malformations consensus document of the International Union of Phlebology (IUP)-2009', International Angiology, vol. 28, pp. 434 - 451
    Journal articles | 2009
    Parsi K; Exner T; Low J; Dang Fung Ma D; Joseph JE, 2009, 'In vitro Effects of Detergent Sclerosants on Antithrombotic Mechanisms', European Journal of Vascular and Endovascular Surgery, vol. 38, pp. 220 - 228, http://dx.doi.org/10.1016/j.ejvs.2009.03.026
    Journal articles | 2008
    Parsi K; Exner T; Connor DE; Herbert AD; Ma DD; Joseph JE, 2008, 'The lytic effects of detergent sclerosants on erythrocytes, platelets, endothelial cells and microparticles are attenuated by albumin and other plasma components in vitro', European Journal of Vascular and Endovascular Surgery, vol. 36, pp. 216 - 223, http://dx.doi.org/10.1016/j.ejvs.2008.03.001
    Journal articles | 2007
    Parsi K; Exner T; Connor DE; Ma DD; Joseph JE, 2007, 'In Vitro Effects of Detergent Sclerosants on Coagulation, Platelets and Microparticles', European Journal of Vascular and Endovascular Surgery, vol. 34 (6), pp. 731 - 740, http://dx.doi.org/10.1016/j.ejvs.2007.07.011
  • Reports | 2016
    Connor DE; Cooley-Andrade O; Goh WX; Fung Ma DD; Parsi K, 2016, Detergent-sclerosants are deactivated and consumed by circulating blood cells

2008

AUD 180,000

BODYFLOW INTERNATIONAL

 

2011

USD 50,000

AMERICAN COLLLEGE OF PHLEBOLOGY

 

2012

AUD 20,698

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

 

2013

AUD 24,396

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

 

2013

EUR 10,000

KREUSSLER PHARMA, GERMANY

 

2014

AUD 35,329

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

 

2015

AUD 48,212

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

 

2015

AUD 55,000

GALDERMA AUSTRALIA

 

2015

USD 50,000

AMERICAN COLLLEGE OF PHLEBOLOGY

 

2016

 

AUD 55,000

GALDERMA AUSTRALIA

2017

 

AUD 49,000

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

2018

 

AUD 83,000

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

2019

 

AUD 55,000

ACADEMY OF PHLEBOLOGY AND LONGEVITY STUDIES

GOLD Medal Recipient      

Australasian College of Phlebology (2018)

for Major Contributions to Phlebology on an International Level

 

Visiting Professor

Royal Society of Medicine (UK, 2019)

 

Member of Honour

2013    Argentinian Society of Phlebology and Lymphology

2018    French Society of Phlebology

We conduct most of our work from Dermatology, Phlebology and Fluid Mechanics Research Laboratory, Level 8, St. Vincent's Centre for Applied Medical Research.

In phlebology, we have investigated sclerosing agents and their interaction with blood components, thrombotic and antithrombotic mechanisms.

My interest in basic science research has focussed on the biological effects sclerosing agents. 

In fluid mechanics, our research has focussed on physics and rheology of sclerosing foams.

In vascular dermatology, we have investigated conditions such as pigmented purpuric dermatosis and vascular malformations.

 

COMPLETED PROJECTS

 

1998-1999                    Imiquimod  Trial in Treatment of Basal Cell Carcinomas

Co-investigator                    Department of Dermatology

Liverpool hospital

 

Publication:

Shumack S, Robinson J, Kossard S, Golitz L, Greenway H, Schroeter A, Andres K, Amies M, Owens M. Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens. Arch Dermatol. 2002 Sep;138(9):1165-71.

 

1999-2000                   Travelers Venous Thromboembolism

Principal Investigator             Master of Science (Medicine)

Departments of Vascular Surgery and Vascular Medicine

St. Vincent’s Hospital

University of New South Wales (UNSW)

 

Publications:

Parsi K, McGrath M, Lord R. Traveller's Venous Thromboembolism. Cardiovascular

Surgery 2001;9: 157-8.

 

1999                             Acitretin in Chemoprevention of Actinic Keratoses and

Study Design                     Squamous Cell Carcinomas in Post-operative Cardiac Transplant Patients

Skin & Cancer Foundation Australia                                                                                    

Department of Cardiothoracic Surgery

St Vincent’s Hospital

University of New South Wales (UNSW)

                                                                                    

                                                  

2004-2011                    Interaction of Detergent Sclerosants with Coagulation,

Principal Investigator           Antithrombotic and Fibrinolytic Mechanisms

Doctor of Philosophy

Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

 

2004-2006                   Electrostimulation in Prevention of Deep Vein

Principal Investigator            Thrombosis

Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

 

2004                            Microbiology of Rosacea

Co-Investigator                  Department of Dermatology

St. Vincent’s Hospital

University of New South Wales (UNSW)

 

 

2004-2007                   Sclerosants, Clotting Factors, Platelets and Microparticles

Principal Investigator             Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Parsi K, Exner T, Connor DE, Ma DDF, Joseph JE. In vitro Effects of Detergent Sclerosants on Coagulation, Platelets and Microparticles. Eur J Vasc Endovasc Surg. 2007;34:731-740.

 

 

2006-2019 

Principal Investigator          The Role of D-dimer in the Differential Diagnosis of Deep Vein Thrombosis and Deep Vein Sclerosis

Haematology Research Lab, St. Vincent’s Hospital

Dermatology, Phlebology and Fluid Mechanics Research Lab,

St. Vincent’s Centre for Applied Medical Research

University of New South Wales (UNSW)

 

This is a prospective study of a cohort of more than 2000 patients undergoing sclerotherapy to assess the role of D-dimer in the evaluation of post-sclerotherapy deep vein occlusion. 

 

Publication:

Parsi K, Panozzo B, Bull A, Yang A, Kang M, Parsi Y, Connor DE. Deep Vein Sclerosis (DVS) Following Sclerotherapy: Ultrasonic and D-Dimer Criteria. Phlebology. 2019 Submitted.

 

 

2007-2008                   The Lytic Effects of Detergent Sclerosants

Principal Investigator           Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Parsi K, Exner T, Connor DE, Herbert A, Ma DDF, Joseph JE. The Lytic Effects of Detergent Sclerosants on Erythrocytes, Platelets, Endothelial Cells and Microparticles are Attenuated by Albumin and other Plasma Components In vitro. Eur J Vasc Endovasc Surg. 2008;36:216-23.

 

 

2007-2011                    Prevention of Venous Gas Embolism in Foam Sclerotherapy

Principal Investigator           Phlebology Research Lab, Sydney Skin & Vein Clinic

 

Publication:

Parsi K. Venous Gas Embolism During Foam Sclerotherapy of Saphenous Veins Despite Recommended Treatment Modifications. Phlebology 2011;4:140-147.

 

2008-2009                   Sclerosants and Antithrombotic Mechanisms

Principal Investigator           Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Parsi K, Exner T, Low J, Ma DDF, Joseph JE. In Vitro Effects of Detergent Sclerosants on Antithrombotic Mechanisms. Eur J Vasc Endovasc Surg. 2009;38:220-8.

 

 

2009-2010                   Sclerosants and Fibrinolytic Mechanisms

Principal Investigator           Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Parsi K, Exner T, Ma DDF, Joseph JE. In vitro Effects of Detergent Sclerosants on Fibrinolytic Enzymes and Inhibitors. Thromb Res. 2010;126:328-36.

 

 

2009-2010                   Sclerosants, Clot Formation and Fibrinolysis

Principal Investigator           Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Parsi K, Exner T, Low J, Ma DDF, Joseph JE. In vitro Effects of Detergent Sclerosants on Clot Formation and Lysis. Eur J Vasc Endovasc Surg. 2010;41:267-77.

 

 

2009-2010                   Fluid Mechanics of Foam Sclerosants 

Co-Investigator                  School of Aerospace, Mechanical & Mechatronic Engineering

and Associate Supervisor       University of Sydney (USYD)

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

This study was a collaboration with the School of Fluid Mechanics, Faculty of Engineering, the University of Sydney and formed an Honours project for Biomedical student Evan Cameron.  

 

Publication:

Cameron E, Chen T, Connor DE, Behnia M, Parsi K. Sclerosant Foam Structure and Stability is Strongly Influenced by Liquid Air Fraction. Eur J Vasc Endovasc Surg. 2013; 46:488-94.

 

 

2010-2011                    Sclerosants and Platelet Activation and Aggregation

Principal Investigator           Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Parsi K, Pilotelle A, Conner DE, Exner T, Lowe J, Ma DDF, Joseph JE. Low Concentration Detergent Sclerosants Induce Platelet Activation but Inhibit Aggregation due to Suppression of GPIIb/IIIa Activation in vitro. Thromb Haemost. 2012; 130:472-8.

 

2008-2013                   In vivo Effects of Detergent Sclerosants on Coagulation,

Principal Investigator           Antithrombotic and Fibrinolytic Mechanisms

Haematology Research Lab, St. Vincent’s Hospital

Phlebology Research Lab, Sydney Skin & Vein Clinic

University of New South Wales (UNSW)

 

Publication:

Connor D, Joseph J, Exner T, Ma D, Parsi K. Infusion of foam sclerosants results in a distance-dependent procoagulant activity, haemoconcentration and elevation of D-dimer levels. Phlebology 2013; Sep 3.

 

2011-2014                      In vitro Effects of Detergent Sclerosants on Blood Cells, 

Principal Investigator           Inflammation and Angiogenesis

Haematology Research Lab, St. Vincent’s Centre for Applied Medical Research

Dermatology, Phlebology and Fluid Mechanics Research Lab,

St. Vincent’s Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Publication:

Cooley-Andrade O, Jothidas A, Goh WX, Connor DE, Parsi K. Low-concentration detergent sclerosants stimulate white blood cells and release proinflammatory and proangiogenic cytokines in vitro. J Vasc Surg Venous Lymphat Disord. 2014 Oct;2(4):433-40. doi: 10.1016/j.jvsv.2014.02.005

 

2011-                            Computational Fluid Dynamics of Foam Sclerosants 

Co-Investigator                 School of Aerospace, Mechanical & Mechatronic Engineering

and Primary Supervisor        University of Sydney (USYD)

Dermatology, Phlebology and Fluid Mechanics Research Lab,

St. Vincent’s Centre for Applied Medical Research

University of New South Wales (UNSW)

 

This study was a collaboration with the School of Fluid Mechanics, Faculty of Engineering, University of Sydney. 

 

Publication:

Wong K, Chen T, Connor DE, Behnia M, Parsi K.  Computational Fluid Dynamics of Liquid and Foam Sclerosant Injection in a Vein Model. Applied Mechanics and Materials 2013; 553, 293-298

 

 

2012-                            Apoptotic Effects of Detergent Sclerosants

Primary Supervisor                Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Publications:

Cooley-Andrade O, Connor DE, Ma DDF, Weisel JW, Parsi K. Morphological changes in vascular and circulating blood cells following exposure to detergent sclerosants.  Phlebology / Venous Forum of the Royal Society of Medicine 02/2015; DOI: 10.1177/0268355515573686

Cooley-Andrade O, Cheung K, Chew AN, Connor DE, Parsi K. Detergent sclerosants at sub-lytic concentrations induce endothelial cell apoptosis through a caspase dependent pathway. Apoptosis. 2016 Jul;21(7):836-45. doi:10.1007/s10495-016-1252-3.

Cooley-Andrade O, Goh WX, Connor DE, Ma DD, Parsi K. Detergent Sclerosants Stimulate Leukocyte Apoptosis and Oncosis. Eur J Vasc Endovasc Surg. 2016 Jun;51(6):846-56. doi: 10.1016/j.ejvs.2016.03.008.

Yang A, Dhanji P, Wijaya M, Chen X, Cooley-Andrade O, Connor DE, Parsi K. Detergent Sclerosants cause apoptosis of squamous cell carcinoma cells in vitro. J Inv Derm 2019. Submitted.

 

2014-                            Endothelial Cell and Platelet Binding and Activation  

Primary Supervisor                Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Publication:

Connor DE, Cheung K, Gerbelli J, Chew AN, Goonawardhana D, Parsi K. Low Concentration Detergent Sclerosants Induce Endothelial Activation in vitro. Eur J Vasc Endovasc Surg. 2019. Submitted.

 

 

CURRENT and ONGOING PROJECTS

2007-                           Haemostatic Abnormalities in Pigmented Purpuric Dermatoses

Principal Investigator           Department of Dermatology, St. Vincent’s Hospital

Haematology Research Lab, St. Vincent’s Hospital

Dermatology, Phlebology and Fluid Mechanics Research Lab,

St. Vincent’s Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Aims:

To investigate the underlying haemostatic abnormalities in patients with pigmented purpuric dermatoses.

 

2013-                            Identification and Characterisation of Sclerocoagulum

Primary Supervisor                Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Aims:

To investigate the molecular structure of sclerothrombus and how it differs from a fibrin thrombus. In collaboration with Prof. John Weisel, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

 

2015-                            The Role of Tumescent Anaesthesia in the Management of Arteriovenous Malformations

Primary Supervisor                Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

Aims:

To investigate the role of tumescent anaesthesia in vessel wall approximation during endovenous ablative procedures.

 

 

2016-                           Compression Stockings and Compression of Superficial Veins  

Primary Supervisor                Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Aims:

To investigate whether compression stockings actually compress superficial veins.

 

Publication:

Yang A, Yasaman B, Parsi Y, Kang M, Connor D, Parsi K. Two layers of graduated compression stockings can reduce healthy saphenous vein diameters in the standing position. Phlebology. 2019 Feb 10:268355519828871. doi: 10.1177/0268355519828871.

 

2017-                            Restless Leg Syndrome

Primary Supervisor                Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Aims:

To investigate the contribution of venous disease to the pathophysiology of restless leg syndrome.

 

 

2018-                            Vascular Aetiology of Reticulate Eruptions

Primary Supervisor                 Dermatology, Phlebology and Fluid Mechanics Research Laboratory

St. Vincent’s  Centre for Applied Medical Research

University of New South Wales (UNSW)

 

Aims:  To investigate the underlying vascular abnormalities in the pathogenesis of reticulate eruptions.

 

AUSTRALASIAN COLLEGE OF PHLEBOLOGY

LEAD AUTHOR, CYANOACRYLATE GLUE IN PERIPHERAL VEINS CONSENSUS, 2019

MEMBER, ULTRASOUND GUIDED SCLEROTHERAPY, 2016

MEMBER, DIRECT VISION SCLEROTHERAPY, 2016

MEMBER, ENDOVENOUS LASER ABLATION STANDARDS , 2010

MEMBER, ULTRASOUND GUIDED SCLEROTHERAPY, 2010

MEMBER, DIRECT VISION SCLEROTHERAPY, 2010

 

UIP INTERNATIONAL CONSENSUS GUIDELINES

Lead Author, POST-THROMBOTIC FIBROSIS, 2019

Lead Author, VENOUS MAPPING CONSENSUS COMMITTEE, 2019

Lead Author, CONTRAINDICATION OF SCLEROTHERAPY CONSENSUS COMMITTEE, 2017

MEMBER, FOAM SCLEROTHERAPY CONSENSUS COMMITTEE, 2013

MEMBER, VENOUS ULCERS CONSENSUS COMMITTEE, 2013

MEMBER, CONGENITAL VASCULAR MALFORMATION DIAGNOSTIC COMMITTEE, 2013

MEMBER, VENOUS HAEMODYNAMICS CONSENSUS COMMITTEE, 2012

Lead Author, Phlebology Curriculum, 2009

MEMBER, VENOUS MALFORMATIONS CONSENSUS COMMITTEE, 2008

 

INTERNATIONAL UNION OF ANGIOLOGY (IUA) CONSENSUS GUIDELINES

 

MEMBER, ARTERIO-VENOUS MALFORMATIONS CONSENSUS COMMITTEE, 2010