Associate Professor Kyle Lee Hoehn
Associate Professor

Associate Professor Kyle Lee Hoehn

Science
Biotech & Biomolecular Science

Research Program

My research team investigates mitochondrial function and metabolism in both normal physiology and disease states. We have discovered a novel class of small molecule mitochondrial uncouplers that boost metabolism and decrease oxidative stress. The current focus of our research involves the therapeutic potential of mitochondrial uncouplers to slow aging-related metabolic decline and to reverse metabolic disorders related to obesity, diabetes, and fatty liver disease. 

Selected publications (of 76)

  1. 2020 – Alexopoulos, A.J.; Chen, S-Y.; Brandon, A.E.; Salamoun, J.; Garcia, C.J.; Beretta, M.; Olzomer, E.; Byrne, F.B.; Shah, D.; Lawrence, R.; Carrive, P.; Tucker, S.P.; Cooney, G.J.; Santos, WL; Hoehn KL. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nature Communications. May 14;11(1):2397. doi: 10.1038/s41467-020-16298-2.
  2. 2020 – Salamoun J, Garcia C, Hargett S, Murray J, Chen SY, Beretta M, Alexopoulos S, Shah D, Olzomer E, Tucker S, Hoehn KL*, and Santos WL*. 6-Amino-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Non-alcoholic Steatohepatitis. Journal of Medicinal Chemistry. Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. *co-corresponding.
  3. 2020 – Childress E, Salamoun J, Hargett SH, Alexopoulos SJ, Chen SY, Shah D, Santiago-Rivera J, Garcia C, Dai Y, Tucker SJ, Hoehn KL*, and Santos WL*. [1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives  as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis. Journal of Medicinal Chemistry. Feb 4. doi: 10.1021/acs.jmedchem.9b01440 *co-corresponding.
  4. 2020 - Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP. BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Molecular Medicine. Jun 10:e12088. doi: 10.15252/emmm.202012088. 
  5. 2020 - Murray J, Hargett S, Hoehn KL*, and Santos W*L. Anilinopyrazines as potential mitochondrial uncouplers, Bioorganic Medicinal Chemistry Letters. Apr 15;30(8):127057. doi: 10.1016/j.bmcl.2020.127057.*co-corresponding.
  6. 2020 - Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N, and Hoehn KL. Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress. Redox Biology. Jan;28:101374. doi: 10.1016/j.redox.2019.101374. 
  7. 2020 - Knights AJ, Vohralik EJ, Houweling PJ, Stout ES, Norton LJ, Alexopoulos SJ, Yik JJ, Mat Jusoh H, Olzomer EM, Bell-Anderson KS, North KN, Hoehn KL, Crossley M, Quinlan KGR. Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Nature Communications. Jun 10;11(1):2922. doi: 10.1038/s41467-020-16758-9.
  8. 2018 – Byrne FL, Hargett SR, Lahiri S, Roy RJ, Berr SS, Caldwell SH, Hoehn KL. Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth. Cancers. Sep 5;10(9). doi: 10.3390/cancers10090312.
  9. 2017 – Nelson ME, Lahiri S, Chow JDY, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, and Hoehn KL. Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defense and promoting cell survival. Nature Communications. Mar 14;8:14689. doi: 10.1038/ncomms14689.
  10. 2015 – Healy ME, Chow JDY, Byrne FL, Breen DS, Leitinger N, Li C, Lackner C, Caldwell SH, and Hoehn KL. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. Journal of Hepatology. Mar;62(3):599-606.
  11. 2015 – Serasinghe MN, Weider SY, Thibaud TR, Elkholi R, Asciolla JJ, Yao JL, Jabado O, Hoehn K, Kageyama Y, Sesake H, and Chipuk JE. Mitochondrial division is requisite to RAS-induced transformation and targeted by mitooncogenic MAPK pathway inhibitors. Molecular Cell. Feb 5;57(3):521-536.
  12. 2015 – Kashatus JA, Nascimento A, Myers L, Sher A, Byrne FL, Hoehn KL, Counter CM, and Kashatus DF. Erk2 phosphorylation of Drp1 promotes mitochondrial fission and Ras-driven tumor growth. Molecular Cell. Feb 5;57(3):537-551.
  13. 2013 – Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, and Hoehn KL. Opening of the Mitochondrial Permeability Transition Pore is Required for Insulin Resistance in Skeletal Muscle. Molecular Metabolism. Nov 26;3(2):124-34.
  14. 2013 – Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Columbus L, Lynch KR, Ravichandran KS, Yan Z, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, and Hoehn KL. Identification of a Novel Mitochondrial Uncoupler that Does Not Depolarize the Plasma Membrane. Molecular Metabolism. Nov 28;3(2):114-23.
  15. 2011 – Park D, Han C, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, and Ravichandaran KS. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature. Aug 21; 477(7363):220-4.
  16. 2010 - Hoehn KL*, Turner N*, Swarbrick MM, Wilks D, Preston E, Phua Yuwei, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, and Cooney GJ. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole body energy expenditure or adiposity. Cell Metabolism. Jan; 11(1):70-6.  
  17. 2009 - Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Insulin resistance is a cellular antioxidant defense mechanism. PNAS. Oct 20; 106 (42):17787-92.
  18. 2008 - Hoehn KL, Hohnen-Behrens C, Cederberg A, Turner N, Wu L, Yuasa T, Ebina Y, James DE.  IRS-1 Independent Defects Define Major Nodes of Insulin Resistance. Cell Metabolism. May; 7(5):421-33.

Education

  • Bachelor degree in Chemistry, Univ. of Northern Colorado 2000
  • Bachelor degree in Biology, Univ. of Northern Colorado 2000
  • Master of Science degree in Biochemistry, Colorado State University 2001
  • PhD degree in Biochemistry and Molecular Biology, Colorado State University 2005

Research Projects

  • To identify new molecules that improve healthy ageing
  • To develop molecules that reverse obesity and metabolic diseases
  • To develop new and better chemical tools for assessing mitochondrial function
  • To determine how dietary nutrients contribute to cancer initiation and/or progression
Phone
+61 (2) 9385 9399
Location
School of Biotechnology and Biomolecular Sciences

Publications

  • Book Chapters | 2003
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Summers SA, 2003, 'Assaying AKT/Protein Kinase B Activity', in Diabetes Mellitus, pp. 137 - 144, http://dx.doi.org/10.1385/1-59259-377-1:137
  • Journal articles | 2021
    Associate Professor Kyle Lee Hoehn
    Srivastava P; Gunawan C; Soeriyadi A; Amal R; Hoehn K; Marquis C, 2021, 'In vitro coronal protein signatures and biological impact of silver nanoparticles synthesized with different natural polymers as capping agents', NANOSCALE ADVANCES, vol. 3, pp. 4424 - 4439, http://dx.doi.org/10.1039/d0na01013h
    Journal articles | 2021
    Associate Professor Kyle Lee Hoehn
    Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Hargett SR; Childress ES; Salamoun JM; Aleksovska I; Roseblade A; Cranfield C; Rawling T; Quinlan KGR; Morris MJ; Tucker SP; Santos WL; Hoehn KL, 2021, 'Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake', Metabolism: Clinical and Experimental, vol. 117, pp. 154724, http://dx.doi.org/10.1016/j.metabol.2021.154724
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Flynn MC; Kraakman MJ; Tikellis C; Lee MKS; Hanssen NMJ; Kammoun HL; Pickering RJ; Dragoljevic D; Al-Sharea A; Barrett TJ; Hortle F; Byrne FL; Olzomer E; McCarthy DA; Schalkwijk CG; Forbes JM; Hoehn K; Makowski L; Lancaster GI; El-Osta A; Fisher EA; Goldberg IJ; Cooper ME; Nagareddy PR; Thomas MC; Murphy AJ, 2020, 'Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis', Circulation Research, vol. 127, pp. 877 - 892, http://dx.doi.org/10.1161/CIRCRESAHA.120.316653
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, vol. 11, pp. 2397, http://dx.doi.org/10.1038/s41467-020-16298-2
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Childress ES; Salamoun JM; Hargett SR; Alexopoulos SJ; Chen SY; Shah DP; Santiago-Rivera J; Garcia CJ; Dai Y; Tucker SP; Hoehn KL; Santos WL, 2020, 'Oxadiazolo[3,4- b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, vol. 63, pp. 2511 - 2526, http://dx.doi.org/10.1021/acs.jmedchem.9b01440
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Salamoun JM; Garcia CJ; Hargett SR; Murray JH; Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Tucker SP; Hoehn KL; Santos WL, 2020, '6-Amino[1,2,5]oxadiazolo[3,4- b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, vol. 63, pp. 6203 - 6224, http://dx.doi.org/10.1021/acs.jmedchem.0c00542
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, vol. 28, pp. 101374 - 101374, http://dx.doi.org/10.1016/j.redox.2019.101374
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Knights AJ; Vohralik EJ; Houweling PJ; Stout ES; Norton LJ; Alexopoulos SJ; Yik JJ; Mat Jusoh H; Olzomer EM; Bell-Anderson KS; North KN; Hoehn KL; Crossley M; Quinlan KGR, 2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, vol. 11, pp. 2922, http://dx.doi.org/10.1038/s41467-020-16758-9
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Axelrod CL; King WT; Davuluri G; Noland RC; Hall J; Hull M; Dantas WS; Zunica ERM; Alexopoulos SJ; Hoehn KL; Langohr I; Stadler K; Doyle H; Schmidt E; Nieuwoudt S; Fitzgerald K; Pergola K; Fujioka H; Mey JT; Fealy C; Mulya A; Beyl R; Hoppel CL; Kirwan JP, 2020, 'BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control', EMBO Molecular Medicine, vol. 12, http://dx.doi.org/10.15252/emmm.202012088
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Murray JH; Hargett S; Hoehn KL; Santos WL, 2020, 'Anilinopyrazines as potential mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, vol. 30, http://dx.doi.org/10.1016/j.bmcl.2020.127057
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Märklin M; Tandler C; Kopp HG; Hoehn KL; Quintanilla-Martinez L; Borst O; Müller MR; Saur SJ, 2020, 'C-Cbl regulates c-MPL receptor trafficking and its internalization', Journal of Cellular and Molecular Medicine, vol. 24, pp. 12491 - 12503, http://dx.doi.org/10.1111/jcmm.15785
    Journal articles | 2020
    Associate Professor Kyle Lee Hoehn
    Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, vol. 10, pp. 8182, http://dx.doi.org/10.1038/s41598-020-65182-y
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, vol. 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Cantley J; Davenport A; Vetterli L; Nemes NJ; Whitworth PT; Boslem E; Thai LM; Mellett N; Meikle PJ; Hoehn KL; James DE; Biden TJ, 2019, 'Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass', Diabetologia, vol. 62, pp. 99 - 111, http://dx.doi.org/10.1007/s00125-018-4743-7
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Gemta LF; Siska PJ; Nelson ME; Gao X; Liu X; Locasale JW; Yagita H; Slingluff CL; Hoehn KL; Rathmell JC; Bullock TNJ, 2019, 'Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells', Science Immunology, vol. 4, http://dx.doi.org/10.1126/sciimmunol.aap9520
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, vol. 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Jiménez de Oya N; Esler WP; Huard K; El-Kattan AF; Karamanlidis G; Blázquez AB; Ramos-Ibeas P; Escribano-Romero E; Louloudes-Lázaro A; Casas J; Sobrino F; Hoehn K; James DE; Gutiérrez-Adán A; Saiz JC; Martín-Acebes MA, 2019, 'Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models', Emerging Microbes and Infections, vol. 8, pp. 624 - 636, http://dx.doi.org/10.1080/22221751.2019.1604084
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, pp. 728 - 739, http://dx.doi.org/10.1080/14756366.2019.1580276
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, vol. 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063
    Journal articles | 2019
    Associate Professor Kyle Lee Hoehn
    Podwika S; Gabel A; Slack-Davis J; Shupnik M; Hoehn K; Modesitt SC, 2019, 'Physical Activity, Nutrition and Hormone Levels of Postmenopausal Women With and Without Endometrial Cancer [40R]', Obstetrics & Gynecology, vol. 133, pp. 202S - 202S, http://dx.doi.org/10.1097/01.aog.0000559153.05084.de
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth', Cancers, vol. 10, http://dx.doi.org/10.3390/cancers10090312
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, vol. 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice', Journal of Biological Chemistry, vol. 293, pp. 5731 - 5745, http://dx.doi.org/10.1074/jbc.RA117.000808
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Chaudhuri R; Krycer JR; Fazakerley DJ; Fisher-Wellman KH; Su Z; Hoehn KL; Yang JYH; Kuncic Z; Vafaee F; James DE, 2018, 'The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-20104-x
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Childress ES; Alexopoulos SJ; Hoehn KL; Santos WL, 2018, 'Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential', Journal of Medicinal Chemistry, vol. 61, pp. 4641 - 4655, http://dx.doi.org/10.1021/acs.jmedchem.7b01182
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Serasinghe MN; Gelles JD; Li K; Zhao L; Abbate F; Syku M; Mohammed JN; Badal B; Rangel CA; Hoehn KL; Celebi JT; Chipuk JE, 2018, 'Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition', Cell Death and Disease, vol. 9, http://dx.doi.org/10.1038/s41419-017-0044-1
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.32111
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05613-7
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, vol. 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KGR, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, vol. 40, http://dx.doi.org/10.1002/bies.201800098
    Journal articles | 2018
    Associate Professor Kyle Lee Hoehn
    Meher AK; Serbulea V; Upchurch CM; Osinski V; Sahu S; Hargett S; Hoehn KL; Harris TE; Klibanov AL; McNamara CA; Leitinger N, 2018, 'Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.428
    Journal articles | 2017
    Associate Professor Kyle Lee Hoehn
    Krycer JR; Yugi K; Hirayama A; Fazakerley DJ; Quek LE; Scalzo R; Ohno S; Hodson MP; Ikeda S; Shoji F; Suzuki K; Domanova W; Parker BL; Nelson ME; Humphrey SJ; Turner N; Hoehn KL; Cooney GJ; Soga T; Kuroda S; James DE, 2017, 'Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism', Cell Reports, vol. 21, pp. 3536 - 3547, http://dx.doi.org/10.1016/j.celrep.2017.11.085
    Journal articles | 2017
    Associate Professor Kyle Lee Hoehn
    Taddeo EP; Hargett SR; Lahiri S; Nelson ME; Liao JA; Li C; Slack-Davis JK; Tomsig JL; Lynch KR; Yan Z; Harris TE; Hoehn KL, 2017, 'Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-00210-y
    Journal articles | 2017
    Associate Professor Kyle Lee Hoehn
    Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, vol. 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006
    Journal articles | 2017
    Associate Professor Kyle Lee Hoehn
    Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms14689
    Journal articles | 2017
    Associate Professor Kyle Lee Hoehn
    Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, vol. 56, pp. 528 - 537, http://dx.doi.org/10.1007/s12020-017-1297-2
    Journal articles | 2017
    Associate Professor Kyle Lee Hoehn
    Caruana BT; Hoehn KL, 2017, 'The race to find endometrial cancer biomarkers', Surgery for Obesity and Related Diseases, vol. 13, pp. 869 - 870, http://dx.doi.org/10.1016/j.soard.2017.01.042
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Laker RC; Taddeo EP; Akhtar YN; Zhang M; Hoehn KL; Yan Z, 2016, 'The mitochondrial permeability transition pore regulator cyclophilin D exhibits tissue-specific control of metabolic homeostasis', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0167910
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Narayanan S; Nieh AH; Kenwood BM; Davis CA; Tosello-Trampont AC; Elich TD; Breazeale SD; Ward E; Anderson RJ; Caldwell SH; Hoehn KL; Hahn YS, 2016, 'Distinct roles for intracellular and extracellular lipids in hepatitis C virus infection', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0156996
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice', Journal of Endocrinology, vol. 228, pp. 127 - 134, http://dx.doi.org/10.1530/JOE-15-0444
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep22292
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, vol. 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Biwer LA; Taddeo EP; Kenwood BM; Hoehn KL; Straub AC; Isakson BE, 2016, 'Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 671 - 679, http://dx.doi.org/10.1016/j.bbalip.2016.04.014
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, vol. 239, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702
    Journal articles | 2016
    Associate Professor Kyle Lee Hoehn
    Baker W; Paquette C; Byrne FL; Atkins KA; Shupnik M; Modesitt SC; Hoehn KL; Slack-Davis JK, 2016, 'Postmenopausal endometrial cancer patients have significantly higher expression of GLUT6 in the endometrium', Gynecologic Oncology, vol. 141, pp. 175 - 176, http://dx.doi.org/10.1016/j.ygyno.2016.04.456
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Kenwood BM; Calderone JA; Taddeo EP; Hoehn KL; Santos WL, 2015, 'Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, vol. 25, pp. 4858 - 4861, http://dx.doi.org/10.1016/j.bmcl.2015.06.040
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2015, 'Acetyl CoA carboxylase 2 is dispensable for CD8+ T cell responses', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0137776
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Modesitt SC; Hallowell PT; Slack-Davis JK; Michalek RD; Atkins KA; Kelley SL; Arapovic S; Shupnik MA; Hoehn K, 2015, 'Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life', Gynecologic Oncology, vol. 138, pp. 238 - 245, http://dx.doi.org/10.1016/j.ygyno.2015.05.015
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Hargett SR; Walker NN; Hussain SS; Hoehn KL; Keller SR, 2015, 'Deletion of the rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice', American Journal of Physiology - Endocrinology and Metabolism, vol. 309, pp. E233 - E245, http://dx.doi.org/10.1152/ajpendo.00007.2015
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Cronk SM; Kelly-Goss MR; Ray HC; Mendel TA; Hoehn KL; Bruce AC; Dey BK; Guendel AM; Tavakol DN; Herman IM; Peirce SM; Yates PA, 2015, 'Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy', Stem Cells Translational Medicine, vol. 4, pp. 459 - 467, http://dx.doi.org/10.5966/sctm.2014-0108
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Bajwa A; Rosin DL; Chroscicki P; Lee S; Dondeti K; Ye H; Kinsey GR; Stevens BK; Jobin K; Kenwood BM; Hoehn KL; Lynch KR; Okusa MD, 2015, 'Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury', Journal of the American Society of Nephrology, vol. 26, pp. 908 - 925, http://dx.doi.org/10.1681/ASN.2013121351
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, vol. 62, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Serasinghe MN; Wieder SY; Renault TT; Elkholi R; Asciolla JJ; Yao JL; Jabado O; Hoehn K; Kageyama Y; Sesaki H; Chipuk JE, 2015, 'Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors', Molecular Cell, vol. 57, pp. 521 - 536, http://dx.doi.org/10.1016/j.molcel.2015.01.003
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, vol. 57, pp. 537 - 551, http://dx.doi.org/10.1016/j.molcel.2015.01.002
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', npj Systems Biology and Applications, vol. 1, http://dx.doi.org/10.1038/npjsba.2015.10
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Laker R; Taddeo E; Zhang M; Hoehn K; Yan Z, 2015, 'The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue‐Specific Control of Metabolic Homeostasis', The FASEB Journal, vol. 29, http://dx.doi.org/10.1096/fasebj.29.1_supplement.1036.14
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Saur SJ; Märklin M; Ganser M; Hoehn K; David JE; Borst O; Kanz L; Kopp H-G; Mueller MR, 2015, 'C-Cbl Regulates c-Mpl Receptor Trafficking and Its Internalization', Blood, vol. 126, pp. 2388 - 2388, http://dx.doi.org/10.1182/blood.v126.23.2388.2388
    Journal articles | 2015
    Associate Professor Kyle Lee Hoehn
    Modesitt SC; Hallowell PT; Hoehn KL; Slack-Davis JK; Kelley SL; Arapovic S; Shupnik M, 2015, 'Changes in metabolic profiles before and after bariatric surgery in high risk morbidly obese women: Obesity-related carcinogenesis is not all about hormones', Gynecologic Oncology, vol. 137, pp. 26 - 26, http://dx.doi.org/10.1016/j.ygyno.2015.01.060
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, vol. 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Taddeo EP; Laker RC; Breen DS; Akhtar YN; Kenwood BM; Liao JA; Zhang M; Fazakerley DJ; Tomsig JL; Harris TE; Keller SR; Chow JD; Lynch KR; Chokki M; Molkentin JD; Turner N; James DE; Yan Z; Hoehn KL, 2014, 'Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle', Molecular Metabolism, vol. 3, pp. 124 - 134, http://dx.doi.org/10.1016/j.molmet.2013.11.003
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, vol. 74, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Laker RC; Lillard TS; Okutsu M; Zhang M; Hoehn KL; Connelly JJ; Yan Z, 2014, 'Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring', Diabetes, vol. 63, pp. 1605 - 1611, http://dx.doi.org/10.2337/db13-1614
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Laker RC; Xu P; Ryall KA; Sujkowski A; Kenwood BM; Chain KH; Zhang M; Royal MA; Hoehn KL; Driscoll M; Adler PN; Wessells RJ; Saucerman JJ; Yan Z, 2014, 'A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo', Journal of Biological Chemistry, vol. 289, pp. 12005 - 12015, http://dx.doi.org/10.1074/jbc.M113.530527
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2014, 'Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity', Journal of Immunology, vol. 192, pp. 3190 - 3199, http://dx.doi.org/10.4049/jimmunol.1302985
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, vol. 3, pp. 114 - 123, http://dx.doi.org/10.1016/j.molmet.2013.11.005
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Narayanan S; Hoehn K; Kenwood B; Nieh A; Tosello-Trampont A; Davis C; Caldwell S; Hahn Y, 2014, 'Altered lipid metabolism influences course of hepatitis C virus infection and hepatocyte cytokine production', JOURNAL OF IMMUNOLOGY, vol. 192, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2014
    Associate Professor Kyle Lee Hoehn
    Bupp MG; Litvin S; Edwards R; Mihalcoe B; Byrne F; Hoehn K; Anoff J, 2014, 'The forkhead transcription factor, Foxo1, may coordinate naive CD8+T cell homeostasis with energy availability in mice.', JOURNAL OF IMMUNOLOGY, vol. 192, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005135&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Associate Professor Kyle Lee Hoehn
    Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2013.11.005
    Journal articles | 2013
    Associate Professor Kyle Lee Hoehn
    Lira VA; Okutsu M; Zhang M; Greene NP; Laker RC; Breen DS; Hoehn KL; Yan Z, 2013, 'Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance', FASEB Journal, vol. 27, pp. 4184 - 4193, http://dx.doi.org/10.1096/fj.13-228486
    Journal articles | 2013
    Associate Professor Kyle Lee Hoehn
    Cantley J; Whitworth PT; Davenport A; Hoehn KL; James DE; Biden TJ, 2013, 'Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation', DIABETIC MEDICINE, vol. 30, pp. 8 - 9, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316263400049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Associate Professor Kyle Lee Hoehn
    Caldwell S; Hoehn KL; Hahn YS, 2013, 'The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil', Hepatology, vol. 57, pp. 1684 - 1687, http://dx.doi.org/10.1002/hep.26091
    Journal articles | 2012
    Associate Professor Kyle Lee Hoehn
    Patel SA; Hoehn KL; Lawrence RT; Sawbridge L; Talbot NA; Tomsig JL; Turner N; Cooney GJ; Whitehead JP; Kraegen E; Cleasby ME, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity', Endocrinology, vol. 153, pp. 5231 - 5246, http://dx.doi.org/10.1210/en.2012-1368
    Journal articles | 2012
    Associate Professor Kyle Lee Hoehn
    Modesitt SC; Hsu JY; Chowbina SR; Lawrence RT; Hoehn KL, 2012, 'Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer', International Journal of Gynecological Cancer, vol. 22, pp. 732 - 741, http://dx.doi.org/10.1097/IGC.0b013e3182510496
    Journal articles | 2012
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice', The Journal of Biological Chemistry, vol. 287, pp. 15801, http://dx.doi.org/10.1074/jbc.O112.356915
    Journal articles | 2012
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice (Journal of Biological Chemistry (2012) 287, (15801))', Journal of Biological Chemistry, vol. 287, pp. 20468, http://dx.doi.org/10.1074/jbc.A112.356915
    Journal articles | 2012
    Associate Professor Kyle Lee Hoehn
    Cleasby ME; Hoehn KL; Patel SA; Lawrence RT; Sawbridge L; Talbot NA; Turner N; Cooney GJ; Whitehead JP; Kraegen EW, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity', DIABETOLOGIA, vol. 55, pp. S244 - S245, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826501338&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2011
    Associate Professor Kyle Lee Hoehn
    Park D; Han CZ; Elliott MR; Kinchen JM; Trampont PC; Das S; Collins S; Lysiak JJ; Hoehn KL; Ravichandran KS, 2011, 'Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein', Nature, vol. 477, pp. 220 - 224, http://dx.doi.org/10.1038/nature10340
    Journal articles | 2010
    Associate Professor Kyle Lee Hoehn
    Richards AA; Colgrave ML; Zhang J; Webster J; Simpson F; Preston E; Wilks D; Hoehn KL; Stephenson M; Macdonald GAM; Prins J; Cooney GJ; Xu A; Whitehead JR, 2010, 'Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation', Molecular Endocrinology, vol. 24, pp. 229 - 239, http://dx.doi.org/10.1210/me.2009-0133
    Journal articles | 2010
    Associate Professor Kyle Lee Hoehn
    Larance M; Rowland AF; Hoehn KL; Humphreys D; Preiss T; Guilhaus M; James DE, 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, vol. 9, pp. 682 - 694, http://dx.doi.org/10.1074/mcp.M900435-MCP200
    Journal articles | 2010
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Turner N; Swarbrick MM; Wilks D; Preston E; Phua Y; Joshi H; Furler SM; Larance M; Hegarty BD; Leslie SJ; Pickford R; Hoy AJ; Kraegen EW; James DE; Cooney GJ; Hegarty , 2010, 'Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity', Cell Metabolism, vol. 11, pp. 70 - 76, http://dx.doi.org/10.1016/j.cmet.2009.11.008
    Journal articles | 2010
    Associate Professor Kyle Lee Hoehn
    Murrow BA; Hoehn KL, 2010, 'Mitochondrial regulation of insulin action', International Journal of Biochemistry and Cell Biology, vol. 42, pp. 1936 - 1939, http://dx.doi.org/10.1016/j.biocel.2010.08.020
    Journal articles | 2010
    Associate Professor Kyle Lee Hoehn
    Akhtar YN; Lira VA; Zhang M; Okutsu M; Hoehn KL; Yan Z, 2010, 'Genetic ablation of cyclophilin D, a component of the mitochondrial permeability transition pore, improves insulin sensitivity in high-fat fed mice', FASEB JOURNAL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675507150&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Holland WL; Knotts TA; Summers SA, 2010, 'The etiology of obesity-induced insulin resistance', Insulin Resistance: Symptoms, Causes and Treatment, pp. 205 - 238
    Journal articles | 2009
    Associate Professor Kyle Lee Hoehn
    Hoehn K; Salmon A; Hohnen-Behrens C; Turner N; Hoy A; Maghzal G; Stocker R; Van remmen H; Kraegen E; Cooney GJ; Richardson A; James DE, 2009, 'Insulin resistance is a cellular antioxidant defense mechanism', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 17787 - 17792, http://dx.doi.org/10.1073/pnas.0902380106
    Journal articles | 2009
    Associate Professor Kyle Lee Hoehn
    Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, vol. 10, pp. 40 - 47, http://dx.doi.org/10.1016/j.cmet.2009.06.001
    Journal articles | 2009
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Holland WL; Knotts TA; Summers SA, 2009, 'The etiology of obesity-induced insulin resistance', Diabetes Mellitus Research Advances, pp. 99 - 132
    Journal articles | 2008
    Associate Professor Kyle Lee Hoehn
    Yip M; Ramm G; Larance MC; Hoehn K; Wagner M; Guilhaus M; James DE, 2008, 'CaMKII-Mediated Phosphorylation of the Myosin Motor Myolc Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes', Cell Metabolism, vol. 8, pp. 384 - 398, http://dx.doi.org/10.1016/j.cmet.2008.09.011
    Journal articles | 2008
    Associate Professor Kyle Lee Hoehn
    Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, vol. 7, pp. 421 - 433, http://dx.doi.org/10.1016/j.cmet.2008.04.005
    Journal articles | 2007
    Associate Professor Kyle Lee Hoehn
    Turner N; Bruce CR; Beale S; Hoehn K; So T; Rolph MS; Cooney GJ, 2007, 'Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle - Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents', Diabetes, vol. 56, pp. 2085 - 2092, http://dx.doi.org/10.2337/db07-0093
    Journal articles | 2007
    Associate Professor Kyle Lee Hoehn
    Holland WL; Knotts TA; Chavez JA; Wang L-P; Hoehn KL; Summers SA, 2007, 'Lipid mediators of insulin resistance', NUTRITION REVIEWS, vol. 65, pp. S39 - S46, http://dx.doi.org/10.1301/nr.2007.jun.S39-S46
    Journal articles | 2007
    Associate Professor Kyle Lee Hoehn
    Holland WL; Brozinick JT; Wang LP; Hawkins ED; Sargent KM; Liu Y; Narra K; Hoehn KL; Knotts TA; Siesky A; Nelson DH; Karathanasis SK; Fontenot GK; Birnbaum MJ; Summers SA, 2007, 'Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance', Cell Metabolism, vol. 5, pp. 167 - 179, http://dx.doi.org/10.1016/j.cmet.2007.01.002
    Journal articles | 2007
    Associate Professor Kyle Lee Hoehn
    Holland WL; Knotts TA; Chavez JA; Wang LP; Hoehn KL; Summers SA, 2007, 'Lipid mediators of insulin resistance.', Nutrition reviews, vol. 65
    Journal articles | 2007
    Associate Professor Kyle Lee Hoehn
    Holland WL; Knotts TA; Chavez JA; Wang LP; Hoehn KL; Summers SA, 2007, 'Lipid Mediators of Insulin Resistance', Nutrition Reviews, vol. 65, http://dx.doi.org/10.1111/j.1753-4887.2007.tb00327.x
    Journal articles | 2006
    Associate Professor Kyle Lee Hoehn
    Cress KE; Hoehn KL; Florant GL, 2006, 'The hunger switch', The FASEB Journal, vol. 20, pp. a177 - a177, http://dx.doi.org/10.1096/fasebj.20.4.a177-a
    Journal articles | 2004
    Associate Professor Kyle Lee Hoehn
    Stratford S; Hoehn KL; Liu F; Summers SA, 2004, 'Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B', Journal of Biological Chemistry, vol. 279, pp. 36608 - 36615, http://dx.doi.org/10.1074/jbc.M406499200
    Journal articles | 2004
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Hudachek SF; Summers SA; Florant GL, 2004, 'Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, vol. 286, pp. R498 - R504, http://dx.doi.org/10.1152/ajpregu.00509.2003
    Journal articles | 2004
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Hudachek SF; Summers SA; Florant GL, 2004, 'Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 286, http://dx.doi.org/10.1152/ajpregu.00509.2003
    Journal articles | 2003
    Associate Professor Kyle Lee Hoehn
    Hoehn KL; Summers SA, 2003, 'Assaying AKT/protein kinase B activity.', Methods in molecular medicine, vol. 83, pp. 137 - 144, http://dx.doi.org/10.1385/1-59259-377-1:137
  • Conference Papers | 2014
    Associate Professor Kyle Lee Hoehn
    Saur SJ; Maerklin M; Poljak A; Ganser M; James DE; Hoehn K; Kanz L; Kopp H-G; Mueller MR, 2014, 'C-CBL Is a Critical Negative Regulator of Megakaryopoesis', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243500072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2013
    Associate Professor Kyle Lee Hoehn
    Cantley J; Whitworth PT; Davenport A; Hoehn KL; James DE; Biden TJ, 2013, 'Acetyl-CoA carboxylase 1 is a critical regulator of beta cell mass', in DIABETOLOGIA, SPRINGER, Barcelona, SPAIN, Vol. 56, pp. S74 - S74, presented at 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, 23 September 2013 - 27 September 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000329196900166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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