Professor Levon Michael Khachigian
Snr Principal Res Fell NH&MRC

Professor Levon Michael Khachigian

Medicine & Health
School of Medical Sciences

Qualifications: BSc (Hons I) PhD DSc UNSW MIP (Law) UTS

Research Interests

Cardiovascular disease and cancer remain the most prevalent causes of morbidity and mortality. The pathogenesis of these and a myriad of other proliferative, migratory, inflammatory and autoimmune diseases are underpinned by molecular and cellular changes in our blood vessels. Professor Levon Khachigian’s research is uncovering key networks of transcriptional control and inducible gene-regulatory circuits that lead to vascular disease. Building on these mechanistic insights, his group is developing new experimental drugs that have the potential to treat a myriad of health problems, from cancer and arthritis through to eye and heart disease.

Levon heads the Vascular Biology and Translational Research Laboratory within the School of Medical Sciences, UNSW Faculty of Medicine.  His research program sits within UNSW Medicine’s Thematic Areas of Cardiovascular and Cancer Biology, and has two major objectives:

  1. To better understand how potentially harmful genes are controlled in vascular cells. This arm investigates signalling and transcriptional mechanisms of growth factor and pro-inflammatory cytokine-dependent gene expression, post-translational mechanisms that modify protein behaviour, isolation and characterization of new genes that are induced or repressed by acute vascular cell injury, and the molecular control of vascular cell migration and proliferation. The group has considerable expertise in preclinical models of cardiovascular disease and cancer
  2. To develop novel vascular therapeutic agents for cardiovascular and inflammatory disease, tumour growth and metastasis. The lab is harnessing the outcomes of its fundamental research by pioneering the development of novel anti-gene, gene-therapeutic and small molecule pharmacological strategies targeting regulatory genes in experimental vascular diseases.  This involves in-house laboratory research and strategic national and international collaborations with a range of clinical and preclinical specialists, global contract research organisations, leading industrial medicinal chemists and drug development consultants.

Levon received his PhD from UNSW in 1993 and after postdoctoral training in vascular pathobiology at Harvard Medical School returned to the UNSW Centre for Vascular Research (CVR) in 1996 where he established an independent research group. He was appointed Professor in 2004 and Director of CVR in 2009.

If you are a student interested in a research project, scroll down to the bottom of this page for a list of projects.

Broad Research Areas    

  • Cardiovascular Disease
  • Inflammation
  • Cancer
  • Cell Biology and Gene Regulation
  • Pathology

Specific Research Keywords    

  • Cardiovascular and inflammatory disease
  • Oncology, tumour growth and metastasis
  • Molecular and cellular mechanisms
  • Signalling and transcription
  • Transcriptional regulation

Teaching Interests    

  • Drug discovery
  • Molecular pathobiology
  • Molecular biology, signalling and transcriptional control
  • Atherosclerosis and post-angioplasty restenosis
  • Inflammation
  • Angiogenesis
  • Cancer

Funding Sources    

  • National Health and Medical Research Council (NHMRC)
  • National Heart Foundation of Australia (NHF)
  • Australian Research Council (ARC)

Prizes and Distinctions

  • 2021 Distinguished Research Fellow, Australian Cardiovascular Alliance
  • 2017 NHMRC Senior Principal Research Fellowship
  • 2016 Scopus Eureka Prize for Excellence in International Scientific Collaboration (FANTOM5 consortium)
  • 2012 Distinguished Researcher Award, Australian Vascular Biology Society
  • 2010 The Royal Society of Victoria Medal for Excellence in Scientific Research
  • 2010 Premier’s Award for Excellence in Translational Research
  • 2010 Business Events Sydney Ambassador
  • 2009 NHMRC Australia Fellowship
  • 2009 Rotary International Vocational Excellence Award
  • 2007 OSMR Eureka James Callachor Prize for Medical Research
  • 2006 GlaxoSmithKline Award for Research Excellence
  • 2006 Wakefield Medal for Research Supervision
  • 2005 Khwarizmi International Award for Science and Technology
  • 2005 NHMRC Senior Principal Research Fellowship
  • 2004 Australasian Science Prize
  • 2003 C'wealth Health Minister's Award for Excellence in Health and Medical Research
  • 2003 Gottschalk Medal, Australian Academy of Science
  • 2003 Eureka Prize for Scientific Research
  • 2003 Alumni Award for Achievement
  • 2002 NHMRC Principal Research Fellowship
  • 2002 RT Hall Prize, Cardiac Society of Australia & New Zealand
  • 2001 Eppendorf Award for Young Australian Researcher (now Millennium Science Award)
  • 2001 AMGEN Medical Researcher Award
  • 2001 Young Tall Poppy Award
  • 1999 NHMRC Research Fellowship
  • 1997 Glaxo-Wellcome Australia Research Award (NSW)
  • 1997 NHMRC R. Douglas Wright Research Fellowship
  • 1993 NHMRC C.J. Martin Fellowship
  • 1993 J. William Fulbright Award
  • 1993 Rotary Foundation International Ambassadorial Award
  • 1988 Queen Elizabeth II Silver Jubilee Trust Award for Young Australians

Society Past Presidencies

  • Australian Society for Medical Research (ASMR)
  • Australian Vascular Biology Society (AVBS)

Conference Organization

  • Chair, 15th International Vascular Biology Meeting, Sydney
  • Vascular Biology Section Chair & Conference Treasurer, 20th Congress of the International Society on Thrombosis and Haemostasis, Sydney

Selected Publications

Santiago FS, Li Y, Khachigian LM. Serine 26 in early growth response-1 is critical for endothelial proliferation, migration and network formation. Journal of the American Heart Association 2021:10:e020521

Santiago FS, Li Y, Zhong L, Raftery MJ, Lins L, Khachigian LM. Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury. Cardiovascular Research 2021;cvab021

Yeh MC, Wu B, Li Y, Elahy M, Prado-Lourenco L, Sockler J, Lau H, Day RO, Khachigian LM. BT2 suppresses human monocytic-endothelial cell adhesion, bone erosion and inflammation Journal of Inflammation Research 2021;14:1019-1028

Li Y, Alhendi AMN, Yeh MC, Elahy M, Santiago FS, Deshpande NP, Wu B, Chan E, Inam S, Prado-Lourenco L, Marchand J, Joyce RD, Wilkinson-White LE, Raftery MJ, Zhu M, Adamson SJ, Barnat F, Viaud-Quentric K, Sockler J, Mackay JP, Chang A, Mitchell P, Marcuccio SM, Khachigian LM. Thermostable small molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis. Science Advances 2020;6:eaaz7815

O’Mara C, Coupland L, Kordbacheh F, Quah B, Chang CW, Davis DS, Bezos A, Browne A, Freeman C, Hammill D, Chopra P, Pipa G, Madge P, Gallant E, Segovia C, Dalhunty AF, Arnolda L, Mitchell I, Khachigian LM, Stephens R, von Itzstein M, Parish CR. Neutralizing the pathological effects of extracellular histones with small polyanions. Nature Communications 2020;11:6408

Khachigian LM. Pharmaceutical patents: Reconciling the human right to health with the incentive to invent. Drug Discovery Today 2020; 25:1135-1141

Alam T, Agrawal S, Severin J, Young RS, Andersson R, Arner E, Hasegawa A, Lizio M, Ramilowski J, Abugessaisa I, Ishizu Y, Noma S, Tarun H, Taylor MS, Lassmann T, Itoh M, Kasukawa T, Kawaji H, Marchionni L, Sheng G, Forrest A, Khachigian LM, Hayashizaki Y, Carninci P, de Hoon MJL. Comparative transcriptomics of primary cells in vertebrates. Genome Research 2020; 30:951-961

Allahwala UK, Khachigian LM, Nour D, Ridiandres A, Billah M, Ward M, Weaver J, Bhindi R. Recruitment and maturation of the coronary collateral circulation: current understanding and perspectives in arteriogenesis. Microvascular Research 2020; 132:104058

Billah M, Ridiandries A, Allahwala UK, Mudaliar H, Dona A, Hunyor S, Khachigian LM, Bhindi R.  Remote ischemic preconditioning induces cardioprotective autophagy and signals through IL-6 dependent JAK-STAT pathway. International Journal of Molecular Sciences 2020; 21:1692

Khachigian LM. Repurposing drugs for skin cancer. Current Medicinal Chemistry 2020;27:7214-7221

Li Y, Acharya G, Elahy M, Xin H, Khachigian LM. The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation. Cancer Letters 2019: 459:268-276

Khachigian LM. Deoxyribozymes as catalytic nanotherapeutic agents. Cancer Research 2019; 79: 879-888

Billah M, Ridiandries A, Rayner BS, Allahwala U, Dona A, Khachigian LM, Bhindi R. Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection. Basic Research in Cardiology 2019; 115:2

Santiago FS, Sanchez-Guerrero E, Zhang G, Zhong L, Raftery MJ, Khachigian LM. Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26. Biochemical and Biophysical Research Communications 2019: 510:345-351

Billah M, Ridiandries A, Allahwala U, Mudaliar H, Dona A, Hunyor S, Khachigian LM, Bhindi R. Circulating mediators of remote ischemic preconditioning.  Oncotarget 2019; 10:216-244

Khachigian LM. Transcription factors targeted by miRNAs regulating smooth muscle cell growth and intimal thickening after vascular injury. International Journal of Molecular Sciences 2019; 20:E5445

Alhendi AMN, Patrikakis M, Daub CO, Kawaji H, Itoh M, de Hoon M, Carninci P, Hayashizaki Y, Arner E, Khachigian LM. Promoter usage and dynamics in vascular smooth muscle cells exposed to fibroblast growth factor-2 or interleukin-1β.  Scientific Reports 2018; 8:13164

Cai H, Cho EA, Li Y, Sockler J, Parish CR, Chong BH, Edwards J, Dodds TJ, Ferguson PM, Wilmott JS, Scolyer RA, Halliday GM, Khachigian LM.  Melanoma protective anti-tumor immunity activated by catalytic DNA.  Oncogene 2018; 37:5115-26

Cannistraci CV, Nieminen T, Nishi M, Khachigian LM, Viikila J, Laine M, Cianflone D, Maseri A, Keong YK, Bhindi R, Ammirati E. “Summer shift”: a potential effect of sunshine on the time onset of ST-elevation acute myocardial infarction. Journal of the American Heart Association

Sheahan AV, Biankin AV, Parish CR, Khachigian LM. Targeted therapies in the management of locally advanced and metastatic pancreatic cancer. Oncotarget 2018; 9:21613-21627

Khachigian LM. The yin and yang of YY1 in tumor growth and suppression. International Journal of Cancer 2018; 143:460-465

Buckler JN, Banwell MG, Kordbacheh F, Parish CR, Santiago FS, Khachigian LM.   Developing neolignans as pro-angiogenic agents: stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4′-coniferyl ethers. ACS Omega 2017; 2: 7375-7388

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manade R, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton R, Babina M, Baillie LM, Barnett T, Beckhouse A, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle A, Clevers H, Davis C, Dietmar M, Dohi T, Edge A, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Baglioni M, Fairbairn L, Farah-Carson M, Faulkner G, Ferrai C, Fisher M, Forrester L, Fujita R, Furusawa J, Geijtenbeek T, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha T, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heating P, Hitchens K, Hume D, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura Y, Kempfle J, Kenna T, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken P, Knox A, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris K, Mothashi H, Mummery C, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin X, Rehli M, Rizzu P, Roy S, Sajantila A, Shimon S, Sato H, Satoh H, Savvi S, Saxena A, Schmidt C, Schneider C, Schulze-Tanzöl G, Schneemann A, Sheng G, Shin J, Sugiyama D, Sugiyama T, Summers K, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyota H, van de Wetering M, van den Berg L, Verardo R, Vijayan D, Wells C, Winterinham L, Wolventang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang P, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin A, Sengstag T, Severin J, Shimoji H, Suzuki M, Kawai J, Suzuki H, Kondo N, Itoh M, Daub C, Kasukawa T, Carninci P, Kawaji H, Forrest A, Hayashizaki Y. FANTOM5 CAGE profiles of human and mouse samples. Scientific Data 2017; 4:170112

Li Y, McRobb LS, Khachigian LM.  MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury.  International Journal of Cardiology 2016; 212:299-302

Li Y, McRobb LS, Khachigian LM.  Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide. International Journal of Cardiology 2016; 220:185-191

Khachigian LM. Early growth response-1 in the pathogenesis of cardiovascular disease. Journal of Molecular Medicine 2016; 94:747-53

Arner E, Daub CO, Vitting-Seerup K, Andersson RA, Lilje B, Drablos F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi A, Arner P, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, et al. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 2015; 347:1010-4

Aitken S, Shigeyuki Magi S, Alhendi AMN, Itoh M, Kawaji H, Lassmann T, Daub CO, Erik Arner E, Carninci P, Forrest ARR, Hayashizak Y, FANTOM Consortium, Khachigian LM, Okada-Hatakeyama M, Semple CA. Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response. PLoS Computational Biology 2015; 11:e1004217

Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple CA, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furuno M, Furusawa J, Geijtenbeek TB, Gibson A, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Shannan J, Sui H, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, et al. A promoter level mammalian expression atlas. Nature 2014; 507:462-70

Xie J, Zhang S, Hu Y, Li D, Cui J, Xue J, Zhang G, Khachigian LM, Wong J, Sun L, Wang M. Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation. Biochimica et Biophysica Acta-Molecular Basis of Disease 2014; 1842(12 Pt A):2479-88

Cho EA, Moloney FJ, Cai H, Au-Yeung A, China C, Scolyer RA, Yosufi B, Raftery MJ, Deng JZ, Morton SW, Hammond PT, Arkenau HT, Damian DL, Francis DJ, Chesterman CN, Barnetson RStC, Halliday GM, Khachigian LM. Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a Phase 1 first-in-human trial (DISCOVER). The Lancet 2013;381:1835-43

Yee GPC, de Souza P, Khachigian LM. Current and potential treatments for cervical cancer. Current Cancer Drug Targets 2013;13:205-20

Li Y, Bhindi R, Deng ZJ, Morton SW, Hammond PT, Khachigian LM. Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine. International Journal of Cardiology 2013;168:3659-3664

Sanchez-Guerrero E, Jo SR, Chong BH, Khachigian LM. EGFR and the complexity of receptor crosstalk in the cardiovascular system. Current Molecular Medicine 2013; 13:3-12

Sheahan AV, Phillips PA, Khachigian LM. Therapeutic perspectives on pancreatic cancer. Current Cancer Drug Targets 2013;13:400-10

Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong TW, Chesterman CN, Francis DJ, Moloney FJ, Barnetson RStC, Halliday GM, Khachigian LM. DNAzyme targeting c-jun suppresses skin cancer growth. Science Translational Medicine 2012;4:139ra82

Sanchez-Guerrero E, Chen E, Kockx M, An SW, Chong BH, Khachigian LM. IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM. PLoS ONE 2012;7:e39811

Chan CWS, Kaplan W, Parish CR, Khachigian LM. Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme. PLoS ONE 2012;7:e39160

Malabanan K, Nath A, Khachigian LM. Platelet-derived growth factor-BB mediates cell migration through Induction of activation transcription factor-4 and tenascin C. American Journal of Pathology 2012;180:2590-7

Zhang N, Chan CS, Sanchez-Guerrero E, Khachigian LM. Repression of PDGF-R-alpha after cellular injury involves TNF-alpha, formation of a c-Fos-YY1 complex and negative regulation by HDAC. American Journal of Physiology-Cell Physiology 2012;302:C1590-8

Ishii H, Hulett MD, Li JM, Santiago FS, Parish CR, Khachigian LM. Yin yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1. International Journal of Oncology 2012;40:1575-80

Little PJ, Getachew R, Rezaei HB, Sanchez-Guerrero E, Khachigian LM, Wang H, Liao S, Zheng W, Ballinger ML, Osman N. Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGF-beta receptor phosphorylation. Archives of Biochemistry and Biophysics 2012;525:25-31

Bhindi R, Fahmy RG, McMahon AC, Khachigian LM, Lowe HC. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion. Journal of Pathology 2012;227:157-64

Perdomo J, Jiang X-M, Khachigian LM, Chong BH. SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. PLoS ONE 2012;7:e50637

Hitchins M, Rapkins R, Chau-To K, Srivastava S, Wong J, Khachigian LM, Polly P, Goldblatt J, Ward RL. Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR. Cancer Cell 2011;20:200-13

Chen JB, Liu M, Parish CR, Chong BH, Khachigian LM. Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.  International Journal of Biochemistry & Cell Biology 2011;43:905-12

Li D, Bhindi R, Khachigian LM. Recent developments in drug eluting stents. Journal of Molecular Medicine 2011;89:545-53

Truong A, Wong TY, Khachigian LM. Emerging therapeutic approaches in the management of retinal angiogenesis and edema. Journal of Molecular Medicine 2011; 89:343-61

Beck K, Wu BJ, Ni J, Santiago FS, Malabanan K, Li C, Wang Y, Khachigian LM, Stocker R. Interplay between heme oxygenase-1 and the multifunctional transcription factor Yin Yang 1.  Circulation Research 2010;107:1490-7

Liang SX, Pinkevych M, Khachigian LM, Parish CR, Davenport MP, Chong BH. Drug-induced thrombocytopenia: Development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG. Blood 2010;116:1958-60

Chan JC, Prado-Lourenco L, Khachigian LM, Di Bartolo B, Bennett MR, Kavurma MM.  TRAIL promotes VSMC proliferation and neointima formation after arterial injury in a FGF-2, Sp1 and NFkappaB-dependent manner. Circulation Research 2010;106:1061-71

Wang B, Chen J, Santiago FS, Janes M, Kavurma MM, Chong BH, Pimanda JE, Khachigian LM. Phosphorylation and acetylation of histone H3 and autoregulation by EGR-1 mediate IL-1beta induction of EGR-1 transcription.  Arteriosclerosis, Thrombosis and Vascular Biology 2010;30:536-45

Luo X, Cai H, Ni J, Bhindi R, Lowe HC, Chesterman CN, Khachigian LM. c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury. Arteriosclerosis, Thrombosis and Vascular Biology 2009;29:1836-42

Tan NY, Khachigian LM. Sp1 phosphorylation and its regulation of gene transcription.  Molecular and Cellular Biology 2009;29:2483-8

Abdel-Malak NA, Mayaki D, Khachigian LM, Hussain SNA. Early growth response-1 regulates angiopoeitin-1-induced endothelial cell proliferation, migration and differentiation. Arteriosclerosis, Thrombosis and Vascular Biology 2009;29:209-16

Malabanan K, Kanellakis P, Bobik A, Khachigian LM. ATF-4 induced by FGF-2 regulates VEGF-A transcription in vascular SMCs and mediates intimal thickening in rat arteries following balloon injury. Circulation Research 2008;103:378-87

Tan N, Midgley VC, Kavurma MM, Santiago FS, Luo X, Peden R, Fahmy RG, Berndt MC, Molloy MP, Khachigian LM. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circulation Research 2008;102:e38-51

Santiago FS, Ishii H, Shafi S, Khurana R, Kanellakis P, Bhindi R, Ramirez M, Bobik A, Martin J, Chesterman CN, Zachary IC, Khachigian LM. Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly. Circulation Research 2007;101:146-55

Fahmy RG, Waldman A, Zhang G, Mitchell A, Tedla N, Cai H, Chesterman CN, Geczy CR, Perry MA, Khachigian LM. Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun. Nature Biotechnology 2006;24:856-863

Liu MY, Eyries M, Zhang C, Santiago FS, Khachigian LM. Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1. Blood 2006;107:2322-9

Santiago FS, Khachigian LM. Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via co-operative interactions with Sp1.  Circulation Research 2004;95:479-487

Zhang G, Dass CR, Sumithran E, Di Girolamo NR, Sun LQ, Khachigian LM. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents.  Journal of the National Cancer Institute 2004;96:683-696

Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM. Zinc finger transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth.  Nature Medicine 2003;9:1026-1032

Francis DJ, Parish CR, McGarry M, Santiago FS, Lowe HC, Brown KJ, Bingley J, Hayward IP, Cowden WB, Campbell JH, Campbell GR, Chesterman CN, Khachigian LM.  Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling and inhibits proliferation.  Circulation Research 2003;92:e70-77

Khachigian LM, Fahmy RG, Zhang G, Bobryshev YV, Kaniaros A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: inhibition by a novel DNAzyme targeting c-Jun. Journal of Biological Chemistry 2002;277:22985-22991

Rafty LA, Santiago FS, Khachigian LM. NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter. EMBO Journal 2002;21:334-343

Lowe HC, Fahmy RG, Kavurma MM, Baker A, Chesterman CN, Khachigian LM. Catalytic oligodeoxynucleotides define a critical regulatory role for early growth response factor-1 in the porcine coronary artery model of in-stent restenosis.  Circulation Research 2001;89:670-677

Santiago FS, Lowe HC, Kavurma MM, Chesterman CN, Atkins DG, Khachigian LM.  Novel DNA enzyme targeting NGFI-A mRNA inhibits vascular smooth muscle proliferation and regrowth after injury.  Nature Medicine 1999;5:1264-1269

Khachigian LM, Lindner V, Williams AJ, Collins T.  Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 1996; 271:1427-1431

Phone
+61 2 9385 2537
Location
UNSW Medicine

Publications

  • Book Chapters | 2013
    Professor Levon Michael Khachigian
    Prado-Lourenço L; Alhendi AMN; Khachigian LM, 2013, 'Insights into roles of immediate-early genes in angiogenesis', in Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases, pp. 145 - 162, http://dx.doi.org/10.1007/978-3-7091-1428-5_7
    Book Chapters | 2007
    Professor Levon Michael Khachigian
    Khachigian LM; Midgley VC, 2007, 'Early growth response-1 coupling in vascular endothelium', in Endothelial Biomedicine, pp. 818 - 821, http://dx.doi.org/10.1017/CBO9780511546198.091
    Book Chapters | 2005
    Professor Levon Michael Khachigian
    Lowe HC; Khachigian LM; Kritharides L; Johnson JL, 2005, 'Animal Models of Vulnerable Plaque', in High-Risk Atherosclerotic Plaques Mechanisms, Imaging, Models, and Therapy, edn. 1, CRC Press, Florida, pp. 35 - 52
    Books | 2004
    Professor Levon Michael Khachigian
    Khachigian LM, 2004, High-risk atherosclerotic plaques: Mechanisms, imaging, models, and therapy
    Books | 2004
    Professor Levon Michael Khachigian
    Khachigian LM, 2004, Preface
    Book Chapters | 2000
    Professor Levon Michael Khachigian
    Khachigian LM; Takuwa Y; Collins T, 2000, 'Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression', in Control of Gene Expression by Catecholamines and the Renin-Angiotensin System, Springer US, pp. 183 - 186, http://dx.doi.org/10.1007/978-1-4615-4351-0_21
    Book Chapters | 2000
    Professor Levon Michael Khachigian
    Khachigian LM; Silverman ES; Lindner V; Williams A; Chesterman CN; Collins TF, 2000, 'Platelet-derived growth factor: regulation of gene expression and roles in vascular pathobiology', in Platelets, Thrombosis and the Vessel Wall, edn. Original, Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 267 - 286
    Book Chapters | 2000
    Professor Levon Michael Khachigian
    Khachigian LM; Geczy C, 2000, 'Growth factors and cytokines in atherogenesis', in Athersclerosis, edn. Original, Oxford University Press, Oxford, UK, pp. 250 - 266
    Book Chapters | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Rafty LA; Collins TF; Khachigian LM, 2000, 'Biology of platelet derived growth factor', in Skeletal Growth Factors, edn. Original, Lippincott Williams OEM_sqlplus_input_finished, Philadelphia, USA, pp. 129 - 152
  • Journal articles | 2021
    Professor Levon Michael Khachigian
    Grapotte M; Saraswat M; Bessière C; Menichelli C; Ramilowski JA; Severin J; Hayashizaki Y; Itoh M; Tagami M; Murata M; Kojima-Ishiyama M; Noma S; Noguchi S; Kasukawa T; Hasegawa A; Suzuki H; Nishiyori-Sueki H; Frith MC; Abugessaisa I; Aitken S; Aken BL; Alam I; Alam T; Alasiri R; Alhendi AMN; Alinejad-Rokny H; Alvarez MJ; Andersson R; Arakawa T; Araki M; Arbel T; Archer J; Archibald AL; Arner E; Arner P; Asai K; Ashoor H; Astrom G; Babina M; Baillie JK; Bajic VB; Bajpai A; Baker S; Baldarelli RM; Balic A; Bansal M; Batagov AO; Batzoglou S; Beckhouse AG; Beltrami AP; Beltrami CA; Bertin N; Bhattacharya S; Bickel PJ; Blake JA; Blanchette M; Bodega B; Bonetti A; Bono H; Bornholdt J; Bttcher M; Bougouffa S; Boyd M; Breda J; Brombacher F; Brown JB; Bult CJ; Burroughs AM; Burt DW; Busch A; Caglio G; Califano A; Cameron CJ; Cannistraci CV; Carbone A; Carlisle AJ; Carninci P; Carter KW; Cesselli D; Chang JC; Chen JC; Chen Y; Chierici M; Christodoulou J; Ciani Y; Clark EL; Coskun M; Dalby M; Dalla E; Daub CO; Davis CA; de Hoon MJL; de Rie D; Denisenko E; Deplancke B; Detmar M; Deviatiiarov R; Di Bernardo D; Diehl AD; Dieterich LC, 2021, 'Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-23143-7
    Journal articles | 2021
    Professor Levon Michael Khachigian
    Yeh MC; Wu BJ; Li Y; Elahy M; Prado-Lourenco L; Sockler J; Lau H; Day RO; Khachigian LM, 2021, 'BT2 suppresses human monocytic-endothelial cell adhesion, bone erosion and inflammation', Journal of Inflammation Research, vol. 14, pp. 1019 - 1028, http://dx.doi.org/10.2147/JIR.S296676
    Journal articles | 2021
    Professor Levon Michael Khachigian
    Santiago FS; Li Y; Zhong L; Raftery MJ; Lins L; Khachigian LM, 2021, 'Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury.', Cardiovasc Res, http://dx.doi.org/10.1093/cvr/cvab021
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Li Y; Alhendi AMN; Yeh MC; Elahy M; Santiago FS; Deshpande NP; Wu B; Chan E; Inam S; Prado-Lourenco L; Marchand J; Joyce RD; Wilkinson-White LE; Raftery MJ; Zhu M; Adamson SJ; Barnat F; Viaud-Quentric K; Sockler J; Mackay JP; Chang A; Mitchell P; Marcuccio SM; Khachigian LM, 2020, 'Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis', Science Advances, vol. 6, pp. eaaz7815, http://dx.doi.org/10.1126/sciadv.aaz7815
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Billah M; Ridiandries A; Rayner BS; Allahwala UK; Dona A; Khachigian LM; Bhindi R, 2020, 'Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection', Basic Research in Cardiology, vol. 115, http://dx.doi.org/10.1007/s00395-019-0763-9
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Alam T; Agrawal S; Severin J; Young RS; Andersson R; Arner E; Hasegawa A; Lizio M; Ramilowski JA; Abugessaisa I; Ishizu Y; Noma S; Tarui H; Taylor MS; Lassmann T; Itoh M; Kasukawa T; Kawaji H; Marchionni L; Sheng G; Forrest ARR; Khachigian LM; Hayashizaki Y; Carninci P; De Hoon MJL, 2020, 'Comparative transcriptomics of primary cells in vertebrates', Genome Research, vol. 30, pp. 951 - 961, http://dx.doi.org/10.1101/gr.255679.119
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Billah M; Ridiandries A; Allahwala UK; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2020, 'Remote ischemic preconditioning induces cardioprotective autophagy and signals through the IL-6-dependent JAK-STAT pathway', International Journal of Molecular Sciences, vol. 21, pp. 1692 - 1692, http://dx.doi.org/10.3390/ijms21051692
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Meara CHO; Coupland LA; Kordbacheh F; Quah BJC; Chang CW; Simon Davis DA; Bezos A; Browne AM; Freeman C; Hammill DJ; Chopra P; Pipa G; Madge PD; Gallant E; Segovis C; Dulhunty AF; Arnolda LF; Mitchell I; Khachigian LM; Stephens RW; von Itzstein M; Parish CR, 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-20231-y
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Khachigian LM, 2020, 'Pharmaceutical patents: reconciling the human right to health with the incentive to invent', Drug Discovery Today, vol. 25, pp. 1135 - 1141, http://dx.doi.org/10.1016/j.drudis.2020.04.009
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Khachigian LM, 2020, 'Repurposing drugs for skin cancer', Current Medicinal Chemistry, vol. 27, pp. 7214 - 7221, http://dx.doi.org/10.2174/0929867327666191220103901
    Journal articles | 2020
    Professor Levon Michael Khachigian
    Allahwala UK; Khachigian LM; Nour D; Ridiandres A; Billah M; Ward M; Weaver J; Bhindi R, 2020, 'Recruitment and maturation of the coronary collateral circulation: Current understanding and perspectives in arteriogenesis', Microvascular Research, vol. 132, http://dx.doi.org/10.1016/j.mvr.2020.104058
    Journal articles | 2019
    Professor Levon Michael Khachigian
    Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, vol. 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019
    Journal articles | 2019
    Professor Levon Michael Khachigian
    Billah M; Ridiandries A; Allahwala U; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2019, 'Circulating mediators of remote ischemic preconditioning: Search for the missing link between non-lethal ischemia and cardioprotection', Oncotarget, vol. 10, pp. 216 - 244, http://dx.doi.org/10.18632/oncotarget.26537
    Journal articles | 2019
    Professor Levon Michael Khachigian
    Khachigian LM, 2019, 'Transcription factors targeted by miRNAs regulating smooth muscle cell growth and intimal thickening after vascular injury', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20215445
    Journal articles | 2019
    Professor Levon Michael Khachigian
    Li Y; Acharya G; Elahy M; Xin H; Khachigian LM, 2019, 'The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation', Cancer Letters, vol. 459, pp. 268 - 276, http://dx.doi.org/10.1016/j.canlet.2019.05.026
    Journal articles | 2019
    Professor Levon Michael Khachigian
    Khachigian LM, 2019, 'Deoxyribozymes as catalytic nanotherapeutic agents', Cancer Research, vol. 79, pp. 879 - 888, http://dx.doi.org/10.1158/0008-5472.CAN-18-2474
    Journal articles | 2018
    Professor Levon Michael Khachigian
    Khachigian LM, 2018, 'The Yin and Yang of YY1 in tumor growth and suppression', International Journal of Cancer, vol. 143, pp. 460 - 465, http://dx.doi.org/10.1002/ijc.31255
    Journal articles | 2018
    Professor Levon Michael Khachigian
    Cai H; Cho EA; Li Y; Sockler J; Parish CR; Chong BH; Edwards J; Dodds TJ; Ferguson PM; Wilmott JS; Scolyer RA; Halliday GM; Khachigian LM, 2018, 'Melanoma protective antitumor immunity activated by catalytic DNA', Oncogene, vol. 37, pp. 5115 - 5126, http://dx.doi.org/10.1038/s41388-018-0306-0
    Journal articles | 2018
    Professor Levon Michael Khachigian
    Sheahan AV; Biankin AV; Parish CR; Khachigian LM, 2018, 'Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: A systematic review', Oncotarget, vol. 9, pp. 21613 - 21627, http://dx.doi.org/10.18632/oncotarget.25085
    Journal articles | 2018
    Professor Levon Michael Khachigian
    Cannistraci CV; Nieminen T; Nishi M; Khachigian LM; Viikilä J; Laine M; Cianflone D; Maseri A; Yeo KK; Bhindi R; Ammirati E, 2018, '"Summer Shift": A potential effect of sunshine on the time onset of ST-elevation acute myocardial infarction', Journal of the American Heart Association, vol. 7, http://dx.doi.org/10.1161/JAHA.117.006878
    Journal articles | 2018
    Professor Levon Michael Khachigian
    Alhendi AMN; Patrikakis M; Daub CO; Kawaji H; Itoh M; de Hoon M; Carninci P; Hayashizaki Y; Arner E; Khachigian LM, 2018, 'Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-30702-4
    Journal articles | 2017
    Professor Levon Michael Khachigian
    Buckler JN; Banwell MG; Kordbacheh F; Parish CR; Santiago FS; Khachigian LM, 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, vol. 2, pp. 7375 - 7388, http://dx.doi.org/10.1021/acsomega.7b01459
    Journal articles | 2017
    Professor Levon Michael Khachigian
    Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M; Kawashima T; Kojima M; Kubosaki A; Manabe RI; Murata M; Nagao-Sato S; Nakazato K; Ninomiya N; Nishiyori-Sueki H; Noma S; Saijyo E; Saka A; Sakai M; Simon C; Suzuki N; Tagami M; Watanabe S; Yoshida S; Arner P; Axton RA; Babina M; Kenneth Baillie J; Barnett TC; Beckhouse AG; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Carlisle AJ; Clevers HC; Davis CA; Detmar M; Dohi T; Edge BAS; Edinger M; Ehrlund A; Ekwall K; Endoh M; Enomoto H; Eslami A; Fagiolini M; Fairbairn L; Farach-Carson MC; Faulkner GJ; Ferrai C; Fisher ME; Forrester LM; Fujita R; Furusawa JI; Geijtenbeek TB; Gingeras T; Goldowitz D; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Hasegawa Y; Herlyn M; Heutink P; Hitchens KJ; Hume DA; Ikawa T; Ishizu Y; Kai C; Kawamoto H; Kawamura YI; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klein S; Peter Klinken S; Knox AJ; Kojima S; Koseki H; Koyasu S; Lee W; Lennartsson A; MacKay-Sim A; Mejhert N; Mizuno Y; Morikawa H; Morimoto M; Moro K; Morris KJ; Motohashi H, 2017, 'FANTOM5 CAGE profiles of human and mouse samples', Scientific Data, vol. 4, http://dx.doi.org/10.1038/sdata.2017.112
    Journal articles | 2017
    Professor Levon Michael Khachigian
    Murrell M; Khachigian L; Ward MR, 2017, 'Corrigendum to “The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting” [Atherosclerosis 194 (2) (2007) 364–371] (S0021915006006836) (10.1016/j.atherosclerosis.2006.11.016)', Atherosclerosis, vol. 261, pp. 172, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.011
    Journal articles | 2016
    Professor Levon Michael Khachigian
    Li Y; McRobb LS; Khachigian LM, 2016, 'Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide', International Journal of Cardiology, vol. 220, pp. 185 - 191, http://dx.doi.org/10.1016/j.ijcard.2016.06.300
    Journal articles | 2016
    Professor Levon Michael Khachigian
    Khachigian LM, 2016, 'Early growth response-1 in the pathogenesis of cardiovascular disease', Journal of Molecular Medicine, vol. 94, pp. 747 - 753, http://dx.doi.org/10.1007/s00109-016-1428-x
    Journal articles | 2016
    Professor Levon Michael Khachigian
    Li Y; McRobb LS; Khachigian LM, 2016, 'MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury', International Journal of Cardiology, vol. 212, pp. 299 - 302, http://dx.doi.org/10.1016/j.ijcard.2016.03.037
    Journal articles | 2016
    Professor Levon Michael Khachigian
    Tan NY; Li J-M; Stocker R; Khachigian LM, 2016, 'Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement (Retraction of vol 105, pg 422, 2009)', CIRCULATION RESEARCH, vol. 118, pp. E31 - E31, http://dx.doi.org/10.1161/RES.0000000000000090
    Journal articles | 2015
    Professor Levon Michael Khachigian
    Hurst LD; Ghanbarian AT; Forrest ARR; Huminiecki L; Rehli M; Kenneth Baillie J; de Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Alam I; Albanese D; Altschuler GM; Arakawa T; Archer JAC; Arner P; Babina M; Baker S; Balwierz PJ; Beckhouse AG; Pradhan SB; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Maxwell Burroughs A; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson A; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Ho Sui SJ; Hofmann OM, 2015, 'The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome', PLoS Biology, vol. 13, http://dx.doi.org/10.1371/journal.pbio.1002315
    Journal articles | 2015
    Professor Levon Michael Khachigian
    Aitken S; Magi S; Alhendi AMN; Itoh M; Kawaji H; Lassmann T; Daub CO; Arner E; Carninci P; Forrest ARR; Hayashizaki Y; Khachigian LM; Okada-Hatakeyama M; Semple CA; Sandelin A; Wells C; Hume DA; Summers KM; Vitting-Seerup K; Andersson R; Yumoto MN, 2015, 'Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response', PLoS Computational Biology, vol. 11, http://dx.doi.org/10.1371/journal.pcbi.1004217
    Journal articles | 2015
    Professor Levon Michael Khachigian
    Arner E; Daub CO; Vitting-Seerup K; Andersson R; Lilje B; Drabløs F; Lennartsson A; Rönnerblad M; Hrydziuszko O; Vitezic M; Freeman TC; Alhendi AMN; Arner P; Axton R; Baillie JK; Beckhouse A; Bodega B; Briggs J; Brombacher F; Davis M; Detmar M; Ehrlund A; Endoh M; Eslami A; Fagiolini M; Fairbairn L; Faulkner GJ; Ferrai C; Fisher ME; Forrester L; Goldowitz D; Guler R; Ha T; Hara M; Herlyn M; Ikawa T; Kai C; Kawamoto H; Khachigian LM; Klinken SP; Kojima S; Koseki H; Klein S; Mejhert N; Miyaguchi K; Mizuno Y; Morimoto M; Morris KJ; Mummery C; Nakachi Y; Ogishima S; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov D; Passier R; Patrikakis M; Pombo A; Qin XY; Roy S; Sato H; Savvi S; Saxena A; Schwegmann A; Sugiyama D; Swoboda R; Tanaka H; Tomoiu A; Winteringham LN; Wolvetang E; Yanagi-Mizuochi C; Yoneda M; Zabierowski S; Zhang P; Abugessaisa I; Bertin N; Diehl AD; Fukuda S; Furuno M; Harshbarger J; Hasegawa A; Hori F; Ishikawa-Kato S; Ishizu Y; Itoh M; Kawashima T; Kojima M; Kondo N; Lizio M; Meehan TF; Mungall CJ; Murata M; Nishiyori-Sueki H; Sahin S; Nagao-Sato S; Severin J; De Hoon MJL; Kawai J; Kasukawa T; Lassmann T, 2015, 'Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells', Science, vol. 347, pp. 1010 - 1014, http://dx.doi.org/10.1126/science.1259418
    Journal articles | 2015
    Professor Levon Michael Khachigian
    Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2015, 'Erratum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun(Nat.Biotechnol.(2006) 24(856-863))', Nature Biotechnology, vol. 33, pp. 882, http://dx.doi.org/10.1038/nbt0815-882c
    Journal articles | 2014
    Professor Levon Michael Khachigian
    Forrest ARR; Kawaji H; Rehli M; Baillie JK; De Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Altschuler IA; Albanese D; Altschule GM; Arakawa T; Archer JAC; Arner P; Babina M; Rennie S; Balwierz PJ; Beckhouse AG; Pradhan-Bhatt S; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Burroughs AM; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson AP; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Sui SJH; Hofmann OM; Hoof I; Hori F; Huminiecki L, 2014, 'A promoter-level mammalian expression atlas', Nature, vol. 507, pp. 462 - 470, http://dx.doi.org/10.1038/nature13182
    Journal articles | 2014
    Professor Levon Michael Khachigian
    Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2014, 'Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919))', Blood, vol. 124, pp. 3034, http://dx.doi.org/10.1182/blood-2014-09-604066
    Journal articles | 2014
    Professor Levon Michael Khachigian
    Chaabane SC; De Brachéne AC; Essaghir A; Velghe A; Re SL; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108656
    Journal articles | 2014
    Professor Levon Michael Khachigian
    Xie J; Zhang S; Hu Y; Li D; Cui J; Xue J; Zhang G; Khachigian LM; Wong J; Sun L; Wang M, 2014, 'Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1842, pp. 2479 - 2488, http://dx.doi.org/10.1016/j.bbadis.2014.04.017
    Journal articles | 2014
    Professor Levon Michael Khachigian
    Charni Chaabane S; Coomans de Brachène A; Essaghir A; Velghe A; Lo Re S; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PloS one, vol. 9, pp. e108656, http://dx.doi.org/10.1371/journal.pone.0108656
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Rayner BS; Figtree GA; Sabaretnam T; Shang P; Mazhar J; Weaver JC; Lay WN; Witting PK; Hunyor SN; Grieve SM; Khachigian LM; Bhindi R, 2013, 'Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction.', Journal of the American Heart Association, vol. 2, http://dx.doi.org/10.1161/JAHA.113.000023
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Li D; Ilnytskyy Y; Kovalchuk A; Khachigian LM; Bronson RT; Wang B; Kovalchuk O, 2013, 'Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer', Oncotarget, vol. 4, pp. 1373 - 1387, http://dx.doi.org/10.18632/oncotarget.1165
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2013, 'Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27', Blood, vol. 122, pp. 2911 - 2919, http://dx.doi.org/10.1182/blood-2012-12-473017
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Chan CWS; Khachigian LM, 2013, 'DNAzyme delivery approaches in biological settings', Current Medicinal Chemistry, vol. 20, pp. 3448 - 3455, http://dx.doi.org/10.2174/09298673113209990033
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Rayner B; Figtree G; Lay W; Sabaretnam T; Shang P; Mazhar J; Weaver J; Grieve S; Hunyor S; Khachigian L; Bhindi R, 2013, 'SELECTIVE INHIBITION OF THE MASTER REGULATOR TRANSCRIPTION FACTOR EGR-1 USING CATALYTIC OLIGONUCLEOTIDES REDUCES MYOCARDIAL INJURY AND IMPROVES LV SYSTOLIC FUNCTION IN A PRECLINICAL MODEL OF MYOCARDIAL INFARCTION', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 61, pp. E213 - E213, http://dx.doi.org/10.1016/S0735-1097(13)60214-4
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Chong BH; Choi PY; Khachigian LM; Perdomo JS, 2013, 'Drug-induced immune thrombocytopenia', Hematology - Oncology Clinics of North America, vol. 27, pp. 521 - 540, http://dx.doi.org/10.1016/j.hoc.2013.02.003
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Sanchez-Guerrero E; Jo SR; Chong BH; Khachigian LM, 2013, 'EGFR and the complexity of receptor crosstalk in the cardiovascular system', Current Molecular Medicine, vol. 13, pp. 3 - 12, http://dx.doi.org/10.2174/156652413804486313
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Perdomo J; Jiang XM; Carter DR; Khachigian LM; Chong BH, 2013, 'Correction: SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4 (PLoS ONE)', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/annotation/3d7a31cd-09e7-47d1-af57-c58c7082058d
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Ni J; Waldman A; Khachigian LM, 2013, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins (The Journal of Biological Chemistry (2010) 285 (4038-4048))', Journal of Biological Chemistry, vol. 288, pp. 31918, http://dx.doi.org/10.1074/jbc.A109.078345
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Li Y; Bhindi R; Deng ZJ; Morton SW; Hammond PT; Khachigian LM, 2013, 'Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)', International Journal of Cardiology, vol. 168, pp. 3659 - 3664, http://dx.doi.org/10.1016/j.ijcard.2013.05.092
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2013, 'Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction', International Journal of Cardiology, vol. 168, pp. 1679 - 1680, http://dx.doi.org/10.1016/j.ijcard.2013.03.078
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic perspectives on pancreatic cancer', Current Cancer Drug Targets, vol. 13, pp. 400 - 410, http://dx.doi.org/10.2174/1568009611313040004
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic Perspectives on Pancreatic Cancer', Current Cancer Drug Targets, vol. 888, pp. 1 - 6, http://dx.doi.org/10.2174/15680096113138880007
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Sanchez-Guerrero E; Chen E; Kockx M; An S-W; Chong BH; Khachigian LM, 2013, 'Correction: IL-1beta Signals through the EGF Receptor and Activates Egr-1 through MMP-ADAM', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/annotation/a0bc2cbb-0390-4476-833d-30ce4f829794
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Yee GPC; De Souza PL; Khachigian LM, 2013, 'Reducing invasion potential of cervical cancer cells via targeted knockdown of c-Jun.', Journal of Clinical Oncology, vol. 31, pp. e22005 - e22005, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22005
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Khachigian LM, 2013, 'Inhibition of intimal thickening and acceleration of reendothelialization after vascular injury using a cocktail approach', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 32, pp. S64 - S64, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400238&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Professor Levon Michael Khachigian
    Khachigian LM, 2013, 'Nephron regeneration after acute kidney injury in the zebrafish', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 32, pp. S63 - S63, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400237&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Little PJ; Getachew R; Rezaei HB; Sanchez-Guerrero E; Khachigian LM; Wang H; Liao S; Zheng W; Ballinger ML; Osman N, 2012, 'Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFâ receptor phosphorylation', Archives of Biochemistry and Biophysics, vol. 525, pp. 25 - 31, http://dx.doi.org/10.1016/j.abb.2012.05.025
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Zhang N; Chan CWS; Sanchez-Guerrero E; Khachigian LM, 2012, 'Repression of PDGF-R-á after cellular injury involves TNF-á, formation of a c-Fos-YY1 complex, and negative regulation by HDAC', American Journal of Physiology - Cell Physiology, vol. 302, pp. 1590 - 1598, http://dx.doi.org/10.1152/ajpcell.00429.2011
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Bhindi R; Fahmy RG; McMahon AC; Khachigian LM; Lowe HC, 2012, 'Intracoronary delivery of DNAzymes targeting human Egr-1 reduces infarct size following myocardial ischaemia reperfusion', Journal of Pathology, vol. 227, pp. 157 - 164, http://dx.doi.org/10.1002/path.2991
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Midwinter R; Maghzal GJ; Dennis JM; Wu BJ; Cai H; Kapralov AA; Natalia A; Belikova NA; Tyurina YY; Dong LF; Khachigian LM; Neuzil J; Kagan VE; Stocker R, 2012, 'Succinobucol induces apoptosis in vascular smooth muscle cells', Free Radical Biology and Medicine, vol. 52, pp. 871 - 879, http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Ishii H; Hulett M; Li J; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, vol. 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Perdomo J; Jiang X-M; Carter DR; Khachigian LM; Chong BH, 2012, 'SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4', PLoS ONE, vol. 7, pp. e50637 - e50637, http://dx.doi.org/10.1371/journal.pone.0050637
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Chan CWS; Kaplan W; Parish CR; Khachigian LM, 2012, 'Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme', PLoS One, vol. 7, pp. e39160, http://dx.doi.org/10.1371/journal.pone.0039160
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Malabanan KP; Sheahan A; Khachigian LM, 2012, 'Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C', American Journal of Pathology, vol. 180, pp. 2590 - 2597, http://dx.doi.org/10.1016/j.ajpath.2012.02.009
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Rayner B; Figtree G; Lay W; Sabaretnam T; Mazar J; Weaver J; Grieve S; Hunyor S; Khachigian L; Bhindi R, 2012, 'The Intracoronary Delivery of DNAzymes Targeting Egr-1 Upon Restoration of Blood Flow Reduces Inflammation and Subsequent Tissue Damage Following Acute Myocardial Ischemia Reperfusion', Heart, Lung and Circulation, vol. 21, pp. S179 - S179, http://dx.doi.org/10.1016/j.hlc.2012.05.446
    Journal articles | 2012
    Professor Levon Michael Khachigian
    Journal articles | 2011
    Professor Levon Michael Khachigian
    Chen J; Liu M; Parish CR; Chong BH; Khachigian LM, 2011, 'Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 905 - 912, http://dx.doi.org/10.1016/j.biocel.2011.03.004
    Journal articles | 2011
    Professor Levon Michael Khachigian
    Truong A; Wong TY; Khachigian LM, 2011, 'Emerging therapeutic approaches in the management of retinal angiogenesis and edema', Journal of Molecular Medicine, vol. 89, pp. 343 - 361, http://dx.doi.org/10.1007/s00109-010-0709-z
    Journal articles | 2011
    Professor Levon Michael Khachigian
    Liang S; Khachigian LM; Ahmadi Z; Yang ; Liu S; Chong BH, 2011, 'In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1(+) /CD31(+) side-population cells).', Journal of Thrombosis and Haemostasis, vol. 9, pp. 1628 - 1637, http://dx.doi.org/10.1111/j.1538-7836.2011.04375.x
    Journal articles | 2011
    Professor Levon Michael Khachigian
    Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, pp. S70 - S70, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700266&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2011
    Professor Levon Michael Khachigian
    Khachigian LM; Nath A; Malabanan KP, 2011, 'Regulation of cell migration by activation transcription factor-4', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, pp. S71 - S71, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700267&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Ni J; Waldman A; Khachigian LM, 2010, 'c-Jun regulates shear-and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.', The Journal of Biological Chemistry, vol. 285, pp. 4038 - 4048, http://dx.doi.org/10.1074/jbc.M109.078345
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Malabanan KP; Khachigian LM, 2010, 'Activation transcription factor-4 and the acute vascular response to injury.', Journal of Molecular Medicine - Jmm, vol. 88, pp. 545 - 552, http://dx.doi.org/10.1007/s00109-010-0615-4
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Pourgholami MH; Khachigian LM; Fahmy R; Badar S; Wang L; Chu SW; Morris DL, 2010, 'Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis', Biochemical and Biophysical Research Communications, vol. 397, pp. 729 - 734, http://dx.doi.org/10.1016/j.bbrc.2010.06.019
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Ye ; Chan G; Qiao ; Meng ; Luo ; Khachigian LM; Ma ; Deng R; Chen ; Chong BH; Yang , 2010, 'Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway', Haematologica, vol. 95, pp. 1745 - 1753, http://dx.doi.org/10.3324/haematol.2009.020958
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Getachew R; Ballinger M; Burch M; Reid J; Khachigian LM, 2010, 'PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminologycan elongationon biglycan and increases binding to LDL.', Endocrinology, vol. 151, pp. 4356 - 4367, http://dx.doi.org/10.1210/en.2010-0027
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Kavurma MM, 2010, 'TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner', Circulation Research, vol. 106, pp. 1061 - 1071, http://dx.doi.org/10.1161/CIRCRESAHA.109.206029
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Cheng Q; Mckeown S; Santos L; Santiago FS; Khachigian LM; Morand E; Hickey M, 2010, 'Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.', Journal of Immunology, vol. 185, pp. 1238 - 1247, http://dx.doi.org/10.4049/jimmunol.0904104
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Liang SX; Pinkevych M; Khachigian LM; Parish CR; Davenport MP; Chong BH, 2010, 'Drug-induced thrombocytopenia (DITP): development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG', Blood, vol. 116, pp. 1958 - 1960, http://dx.doi.org/10.1182/blood-2010-02-268326
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Ni J; Waldman A; Khachigian LM, 2010, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins(Journal of Biological Chemistry (2018) 293(20307) DOI: 10.1074/jbc.M109.078345)', Journal of Biological Chemistry, vol. 293, pp. 20307, http://dx.doi.org/10.1074/jbc.W118.007069
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1β and forms a cytokine-inducible gene-silencing complex with NF-κB p65 and interferon regulatory factor-1 (Journal of Biological Chemistry (2009) 284, (35101-35112)) DOI: 10.1074/jbc.A109.061903', Journal of Biological Chemistry, vol. 285, pp. 4363
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Perdomo JS; Fock E; Kaur G; Yan F; Khachigian LM; Jans D; Chong BH, 2010, 'A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transciptional activity and platelet production', Journal of Thrombosis and Haemostasis, vol. 8, pp. 2542 - 2553, http://dx.doi.org/10.1111/j.1538-7836.2010.04058.x
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Zhang N; Khachigian LM, 2010, 'Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1 beta (IL-1 beta) release and cooperative transactivation by NF-kappa B and ATF-4. IL-1 beta FACILITATES HDAC-1/2 DISSOCIATION FROM PROMOTER (Retraction of vol 284, pg 27933, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A109.025742
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and interferon regulatory factor-1 (vol 284, pg 35101, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 4263 - 4263, http://dx.doi.org/10.1074/jbc.A109.061903
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Kavurma MM; Bobryshev Y; Khachigian LM, 2010, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1 (Retraction of vol 277, pg 36244, 2002)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A110.200463
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and interferon regulatory factor-1 (Retraction of vol 284, pg 35101, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A209.061903
    Journal articles | 2010
    Professor Levon Michael Khachigian
    Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010) 185 (1238-1247))', Journal of Immunology, vol. 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Wang B; Khachigian LM; Esau L; Birrer M; Zhao X; Parker M; Hendricks D, 2009, 'A Key Role for Early Growth Response-1 and Nuclear Factor-kappa B in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer', Molecular Cancer Research, vol. 7, pp. 755 - 764, http://dx.doi.org/10.1158/1541-7786.MCR-08-0472
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Chan C; Khachigian LM, 2009, 'DNAzymes and their therapeutic possibilities', Internal Medicine Journal, vol. 39, pp. 249 - 251, http://dx.doi.org/10.1111/j.1445-5994.2009.01799.x
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Tan N; Li J; Stocker R; Khachigian LM, 2009, 'Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and fasl-fas engagement', Circulation Research, vol. 105, pp. 422 - 430, http://dx.doi.org/10.1161/CIRCRESAHA.109.203323
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Abdel-Malak N; Mofarrahi M; Mayaki D; Khachigian LM; Hussain S, 2009, 'Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 29, pp. 209 - 216, http://dx.doi.org/10.1161/ATVBAHA.108.181073
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Luo X; Cai H; Ni J; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2009, 'c-Jun DNAzymes Inhibit Myocardial Inflammation, ROS Generation, Infarct Size, and Improve Cardiac Function After Ischemia-Reperfusion Injury', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 29, pp. 1836 - U282, http://dx.doi.org/10.1161/ATVBAHA.109.189753
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Zhang C; Song Q; Khachigian LM; Lubenec I; Shie J; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells', Biochemical and Biophysical Research Communications, vol. 380, pp. 689 - 694, http://dx.doi.org/10.1016/j.bbrc.2009.01.151
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Zhang C; Song Q; Khachigian LM; Lubenec I; Shie J; Yang B; Li J; Tian Y, 2009, 'Retraction notice to `Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells` [Biophys. Res. Commun. 380 (3) (2009) 689-694] (DOI:10.1016/j.bbrc.2009.01.151)', Biochemical and Biophysical Research Communications, vol. 388, pp. 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Tan N; Khachigian LM, 2009, 'Sp1 phosphorylation and its regulation of gene transcription', Molecular and Cellular Biology, vol. 29, pp. 2483 - 2488, http://dx.doi.org/10.1128/MCB.01828-08
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Zhang C; Song QH; Khachigian LM; Lubenec I; Shie J-L; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells (Retraction of vol 380, pg 689, 2009)', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 388, pp. 464 - 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Dass CR; Khachigian LM; Choong PFM, 2009, 'C-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model (Molecular Cancer Research (2008) 6, (1289-1292))', Molecular Cancer Research, vol. 7, pp. 1594, http://dx.doi.org/10.1158/1541-7786.MCR-07-9-COR2
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2009, 'Selected Egr-1-dependent molecules are increased acutely with acute myocardial infarction', Heart, Lung and Circulation, vol. 18, pp. S253 - S254, http://dx.doi.org/10.1016/j.hlc.2009.05.625
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J; Stocker R, 2009, 'Abstract: 81 PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE', Atherosclerosis Supplements, vol. 10, pp. e220 - e220, http://dx.doi.org/10.1016/s1567-5688(09)70224-7
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Ni J; Waldman A; Khachigian LM, 2009, 'c-Jun Induces Intimal Hyperplasia in a Rabbit End-to-Side Autologous Veno-Arterial Transplantation Model', Heart, Lung and Circulation, vol. 18, pp. S110 - S111, http://dx.doi.org/10.1016/j.hlc.2009.05.250
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2009, 'Prolonged Diabetes in Rats is Associated With Increased Myocardial Fibrosis and Profound Sensitivity to Ischaemia', Heart, Lung and Circulation, vol. 18, pp. S314 - S314, http://dx.doi.org/10.1016/j.hlc.2009.05.484
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Khachigian LM; Peter K; Berndt MC, 2009, 'Recent advances in vascular biology: Selected highlights from IVBM 2008', Thrombosis and Haemostasis, vol. 101, pp. 997 - 998, http://dx.doi.org/10.1160/TH09-05-0294
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Khachigian L, 2009, 'DNAZYME TARGETING TRANSCRIPTION FACTOR C-JUN INHIBITS MYOCARDIAL INFLAMMATION, ROS GENERATION AND INFARCT SIZE AFTER ISCHEMIA-REPERFUSION INJURY', ATHEROSCLEROSIS SUPPLEMENTS, vol. 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957101541&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2009, 'Selective Egr-1 Inhibition Reduces Infarct Size in the Diabetic Rat Heart with Myocardial Ischaemia–Reperfusion Injury', Heart, Lung and Circulation, vol. 18, pp. S315 - S315, http://dx.doi.org/10.1016/j.hlc.2009.05.485
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J; Stocker R, 2009, 'PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE-1', ATHEROSCLEROSIS SUPPLEMENTS, vol. 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957100820&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Ni J; Waldman A; Khachigian L, 2009, 'DNA enzyme targeting transcription factor c-Jun reduces intimal hyperplasia in human saphenous vein explants and inhibits Vein Graft stenosis in rabbits', EUROPEAN HEART JOURNAL, vol. 30, pp. 322 - 322, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702603073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Professor Levon Michael Khachigian
    Khachigian LM, 2009, 'Immediate-early genes as master regulators in cancer and other vascular disease', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 24, pp. S77 - S77, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270497500292&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Malabanan KP; Kanellakis P; Bobik A; Khachigian LM, 2008, 'Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury', Circulation Research, vol. 103, pp. 378 - 387, http://dx.doi.org/10.1161/CIRCRESAHA.107.168682
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Dass CR; Khachigian LM; Choong P, 2008, 'c-Jun knockdown sensitizes osteosarcoma to doxorubicin', Molecular Cancer Therapeutics, vol. 7, pp. 1909 - 1912, http://dx.doi.org/10.1158/1535-7163.MCT-08-0086
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Kavurma MM; Schoppet M; Bobryshev YV; Khachigian LM; Bennett MR, 2008, 'TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappa B and induction of insulin-like growth factor-1 receptor', The Journal of Biological Chemistry, vol. 283, pp. 7754 - 7762, http://dx.doi.org/10.1074/jbc.M706927200
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Tan N; Midgley VC; Kavurma MM; Santiago FS; Luo X; Peden RS; Fahmy R; Berndt MC; Molloy M; Khachigian LM, 2008, 'Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific ser/thr residues in the second zinc finger region of Sp1', Circulation Research, vol. 102, pp. E38 - E51, http://dx.doi.org/10.1161/CIRCRESAHA.107.167395
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Dass CR; Friedhuber AM; Khachigian LM; Dunstan DM; Choong PFM, 2008, 'Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity', Journal of Microencapsulation, vol. 25, pp. 421 - 425, http://dx.doi.org/10.1080/02652040802033673
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Dass CR; Choong P; Khachigian LM, 2008, 'DNAzyme technology and cancer therapy: cleave and let die', Molecular Cancer Therapeutics, vol. 7, pp. 243 - 251, http://dx.doi.org/10.1158/1535-7163.MCT-07-0510
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Dass CR; Friedhuber A; Khachigian LM; Dunstan D; Choong P, 2008, 'Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model', Cancer Biology and Therapy, vol. 7, pp. 1033 - 1036, http://dx.doi.org/10.4161/cbt.7.7.6037
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Kavallaris M; Meachem S; Hulett M; West C; Pitt R; Chesters J; Laffan W; Boreham P; Khachigian LM, 2008, 'Perceptions in health and medical research careers: the Australian Society for Medical Research Workforce Survey', Medical Journal of Australia, vol. 188, pp. 520 - 524
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Benson VL; Khachigian LM; Lowe HC, 2008, 'DNAzymes and cardiovascular disease', British Journal of Pharmacology, vol. 154, pp. 741 - 748, http://dx.doi.org/10.1038/bjp.2008.145
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Khachigian LM; Berndt MC; Tan NY, 2008, 'Ang II-Inducible PDGF-D Transcription Requires Ser/Thr Residues In The Second Zinc Finger Region of Sp1: Novel Phosphospecific Antibodies Demonstrate that Sp1 is Phosphorylated by SMC Injury', FASEB JOURNAL, vol. 22, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208467808746&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Sanchez-Guerrero E; Midgley VC; Khachigian LM, 2008, 'Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation', Nucleic Acids Research, vol. 36, pp. 1941 - 1951, http://dx.doi.org/10.1093/nar/gkm923
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Dass CR; Galloway S; Clark J; Khachigian LM; Choong P, 2008, 'Involvement of c-jun in human liposarcoma growth - Supporting data from clinical immunohistochemistry and DNAzyme efficacy', Cancer Biology and Therapy, vol. 7, pp. 1297 - 1301, http://dx.doi.org/10.4161/cbt.7.8.6301
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Dass CR; Khachigian LM; Choong P, 2008, 'C-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model', Molecular Cancer Research, vol. 6, pp. 1289 - 1292, http://dx.doi.org/10.1158/1541-7786.MCR-08-0036
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Khachigian LM; Bobik A; Kanellakis P; Malabanan K, 2008, 'Response to abcouwer and roybal', Circulation Research, vol. 103, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559
    Journal articles | 2008
    Professor Levon Michael Khachigian
    Khachigian LM; Bobik A; Kanellakis P; Malabanan KP, 2008, 'Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 Response', Circulation Research, vol. 103, pp. E119 - E119, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Murrell MJ; Khachigian LM; Ward M, 2007, 'The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting', Atherosclerosis, vol. 194, pp. 364 - 371, http://dx.doi.org/10.1016/j.atherosclerosis.2006.11.016
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin J; Chesterman CN; Zachary I; Khachigian LM, 2007, 'Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21(WAF1/Cip1) transcription and p21(WAF1/Cip1)-Cdk4-cyclin D1 assembly', Circulation Research, vol. 101, pp. 146 - 155, http://dx.doi.org/10.1161/CIRCRESAHA.106.145235
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Bhindi R; Fahmy R; Lowe HC; Chesterman CN; Dass CR; Cairns MJ; Saravolac E; Sun L; Khachigian LM, 2007, 'Brothers in arms - DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies', American Journal of Pathology, vol. 171, pp. 1079 - 1088, http://dx.doi.org/10.2353/ajpath.2007.070120
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Khachigian LM; Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin JL; Chesterman CN; Zachary I, 2007, 'Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly', Federation of American Societies for Experimantal Biology Journal, vol. 21, pp. A69 - A69, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245708500329&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Kavurma MM; Figg N; Bennett MR; Mercer J; Khachigian LM; Uttlewood TD, 2007, 'Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment', Biochemical Journal, vol. 407, pp. 79 - 87, http://dx.doi.org/10.1042/BJ20070380
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Fahmy R; Khachigian LM, 2007, 'Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1', Journal of Cellular Biochemistry, vol. 100, pp. 1526 - 1535, http://dx.doi.org/10.1002/jcb.21145
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Khachigian LM, 2007, 'Science never sleeps: Tucker Collins, MD, PhD', Endothelium - Journal of Endothelial Cell Research, vol. 14, pp. 173 - 174, http://dx.doi.org/10.1080/10623320701670026
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2007, 'The Transcription Factor Egr-1 is Upregulated by Myocardial Ischaemia Reperfusion Injury in an In Vivo Rat Model Of Diabetes', Heart, Lung and Circulation, vol. 16, pp. S23 - S24, http://dx.doi.org/10.1016/j.hlc.2007.06.062
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Lowe HC; Khachigian LM, 2007, 'The streptozotocin-treated Sprague-Dawley rat: A useful model for the assessment of acute and chronic effects of myocardial ischaemia reperfusion injury in experimental diabetes', Diabetes and Vascular Disease Research, vol. 4, pp. 153 - 154, http://dx.doi.org/10.3132/dvdr.2007.035
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2007, 'The transcription factor Egr-1 is implicated in myocardial ischaemic reperfusion injury in an in vivo model of diabetes', Journal of Molecular and Cellular Cardiology, vol. 42, pp. S194 - S194, http://dx.doi.org/10.1016/j.yjmcc.2007.03.590
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Lowe HC; Mcmahon AC; Khachigian LM; Benson VL, 2007, 'The transcription factor early growth response gene 1 (Egr-1) is implicated in acute myocardial ischemic reperfusion injury in an in vivo model of diabetes', EUROPEAN HEART JOURNAL, vol. 28, pp. 434 - 434, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702202289&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2007
    Professor Levon Michael Khachigian
    Kavurma MM; Figg N; Bennett MR; Mercer JL; Khachigian LM; Littlewood T, 2007, 'Oxidative stress regulates IGF1R expression in vascular smooth muscle cells via p53/TBP promoter interactions', Biochemical Journal, vol. 407, pp. 79 - 87, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243520700040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Fahmy R; Waldman A; Zhang GS; Mitchell A; Tedla NT; Cai H; Geczy C; Chesterman CN; Perry MA; Khachigian LM, 2006, 'Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun', Nature Biotechnology, vol. 24, pp. 856 - 863, http://dx.doi.org/10.1038/nbt1225
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM, 2006, 'Early growth response-1 in Cardiovascular Pathobiology', Circulation Research, vol. 98, pp. 186 - 191, http://dx.doi.org/10.1161/01.RES.0000200177.53882.c3
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Liu M; Eyries MM; Zhang C; Santiago FS; Khachigian LM, 2006, 'Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1', Blood, vol. 107, pp. 2322 - 2329, http://dx.doi.org/10.1182/blood-2005-06-2377
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM, 2006, 'Collagen antibody-induced arthritis', Nature Protocols, vol. 1, pp. 2512 - 2516, http://dx.doi.org/10.1038/nprot.2006.393
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM; Fahmy R; Di Girolamo N; Zhang GS, 2006, 'JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation', Journal of Cell Science, vol. 119, pp. 3219 - 3226, http://dx.doi.org/10.1242/jcs.03059
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM; Luo X; Sumithran E; Pua VS; Barnetson R; Halliday GM; Zhang GS, 2006, 'Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression', Oncogene, vol. 25, pp. 7260 - 7266, http://dx.doi.org/10.1038/sj.onc.1209726
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM; Lowe HC; Bhindi R, 2006, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Journal of Thrombosis and Haemostasis, vol. 4, pp. 1479 - 1483, http://dx.doi.org/10.1111/j.1538-7836.2006.02022.x
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM; Witting PK; McMahon AC; Lowe HC; Bhindi R, 2006, 'Rat models of myocardial infarction', Thrombosis and Haemostasis, vol. 96, pp. 602 - 610, http://dx.doi.org/10.1160/TH05-07-0514
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Kingwell B; Anderson GP; Duckett S; Hoole E; Jackson Pulver L; Khachigian LM; Morris ME; Roder D; Rothwell-Short J; Wilson A, 2006, 'Evaluation of NHMRC funded research completed in 1992, 1997 and 2003: gains in knowledge, health and wealth', Medical Journal of Australia, vol. 184, pp. 282 - 286
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Murrell MJ; Khachigian L; Ward MR, 2006, 'The role of c-jun in flow dependent and flow independent restenosis after angioplasty and stenting', Vascular Pharmacology, vol. 45, pp. e59 - e59, http://dx.doi.org/10.1016/j.vph.2006.08.155
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Lowe HC; Khachigian LM, 2006, 'The endothelium and cardiovascular disease: New developments, new challenges', Endothelium: Journal of Endothelial Cell Research, vol. 13, pp. 365, http://dx.doi.org/10.1080/10623320601125303
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Santiago FS; Ishii H; Hulett MD; Bobik A; Martin JF; Chesterman CN; Zachary IC; Khachigian LM, 2006, 'Injury-inducible yin yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing P21WAF1/CIP1 transcription and perturbing cyclin D1-CDK4-P21WAF1/CIP1 assembly', Vascular Pharmacology, vol. 45, pp. e46 - e47, http://dx.doi.org/10.1016/j.vph.2006.08.160
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian LM, 2006, 'Health and medical research funding: an investment in Australia`s future', Medical Journal of Australia, vol. 185, pp. 348 - 350
    Journal articles | 2006
    Professor Levon Michael Khachigian
    Khachigian L, 2006, 'Molecular assassin targets master regulator gene', Australian Life Scientist, vol. 3, pp. 15
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Fisher C; Sanchez-Ruderisch H; Welzel M; Wiedenmann B; Sakai T; Andre S; Gabius H; Khachigian LM; Detjen K; Rosewicz S, 2005, 'Galectin-1 Interacts with the alpha 5 Beta 1 Fibronectin Receptor to Restrict Carcinoma Cell growth via Induction of p21 and p27', The Journal of Biological Chemistry, vol. 280, pp. 37266 - 37277, http://dx.doi.org/10.1074/jbc.M411580200
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Kavurma MM; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2005, 'Vessel wall apoptosis and atherosclerotic plaque instability', Journal of Thrombosis and Haemostasis, vol. 3, pp. 465 - 472, http://dx.doi.org/10.1111/j.1538-7836.2005.01120.x
    Journal articles | 2005
    Professor Levon Michael Khachigian
    de Mestre A; Rao S; Hornby J; Soe-Htwe T; Khachigian LM; Hulett M, 2005, 'Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells', The Journal of Biological Chemistry, vol. 280, pp. 35136 - 35147, http://dx.doi.org/10.1074/jbc.M503414200
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Lowe HC; James B; Khachigian LM, 2005, 'A novel model of in-stent restenosis: rat aortic stenting', Heart, vol. 91, pp. 393 - 395, http://dx.doi.org/10.1136/hrt.2003.028076
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Bhindi R; Brieger D; Ishii H; Di Girolamo N; Kumar RK; Khachigian LM; Lowe HC, 2005, 'Fibroblast growth factor 2 and the transcription factor Egr-l localiseto endothelial cell microvascular channels in human coronary artery occlusion', Thrombosis and Haemostasis, vol. 93, pp. 172 - 174
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Bonello M; Bobryshev YV; Khachigian LM, 2005, 'Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells', American Journal of Pathology, vol. 167, pp. 1149 - 1159, http://dx.doi.org/10.1016/S0002-9440(10)61203-5
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Khachigian LM, 2005, 'Suppressing a sick heart', Nature Medicine, vol. 11, pp. 828 - 829, http://dx.doi.org/10.1038/nm0805-828
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Bonello MR; Khachigian LM, 2005, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter (vol 279, pg 2377, 2004)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, pp. 1704 - 1704, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226195200102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Khachigian LM; Waldman A; Fahmy R; Perry M; Geczy C; Zhang G, 2005, 'Novel Insights into Functions of Immediate-Early Genes In Vascular Permeability and Inflammation using Catalytic DNA', INFLAMMATION RESEARCH, vol. 54, pp. S89 - S89, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000205501600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Bhindi R; Khachigian LM; Lowe HC, 2005, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Circulation, vol. 112, pp. U239 - U239, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000232956401200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Bonello MR; Khachigian LM, 2005, 'Erratum: Fibroblast growth factor-2 represses platelet-derived growth factor receptor-α (PDGFR-α) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-α promoter (Journal of Biological Chemistry (2004) 279 (2377-2382))', Journal of Biological Chemistry, vol. 280, pp. 1704
    Journal articles | 2005
    Professor Levon Michael Khachigian
    Waldman A; Fahmy R; Khachigian LM, 2005, 'DNAzymes targeting c-Jun inhibit inflammation and downregulate endothelial ICAM-1, VCAM-1 and E-selectin expression', Circulation, vol. 112, pp. U319 - U319, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000232956401573&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Zhang GS; Dass CR; Sumithran E; Di Girolamo N; Sun L; Khachigian LM, 2004, 'Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents', Journal of the National Cancer Institute, vol. 96, pp. 683 - 696, http://dx.doi.org/10.1093/jnci/djh120
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Khachigian LM; Parish CR, 2004, 'Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies', Cardiovascular Drug Reviews, vol. 22, pp. 1 - 6
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Santiago FS; Khachigian LM, 2004, 'Ets-1 Stimulates Platelet-Derived Growth Factor A-Chain Gene Transcription and Vascular Smooth Muscle Cell Growth via Cooperative Interactions With Sp1', Circulation Research, vol. 95, pp. 479 - 487, http://dx.doi.org/10.1161/01.RES.0000141135.36279.67
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Mitchell A; Dass CR; Sun L; Khachigian LM, 2004, 'Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1', Nucleic Acids Research, vol. 32, pp. 3065 - 3069, http://dx.doi.org/10.1093/nar/gkh626
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Midgley VC; Khachigian LM, 2004, 'Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1', The Journal of Biological Chemistry, vol. 279, pp. 40289 - 40295, http://dx.doi.org/10.1074/jbc.M406063200
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Kavurma MM; Khachigian LM, 2004, 'Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21(WAF1/Cip1) promoter', Journal of Cellular Biochemistry, vol. 93, pp. 904 - 916, http://dx.doi.org/10.1002/jcb.20238
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Eyries MM; Collins TF; Khachigian LM, 2004, 'Modulation of growth factor gene expression in vascular cells by oxidative stress', Endothelium - Journal of Endothelial Cell Research, vol. 11, pp. 133 - 139, http://dx.doi.org/10.1080/10623320490482691
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Khachigian LM, 2004, 'Early growth response-1: blocking angiogenesis by shooting the messenger', Cell Cycle, vol. 3, pp. 10 - 11
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Sharma L; Melis E; Hickey M; Clyne C; Erlich JH; Khachigian LM; Morand E; Carmeliet P; Tipping P; Davenport P, 2004, 'The cytoplasmic domain of tissue factor contributes to leukocyterecruitment and death in endotoxemia', American Journal of Pathology, vol. 165, pp. 331 - 340, http://dx.doi.org/10.1016/S0002-9440(10)63300-7
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Bonello M; Khachigian LM, 2004, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter', The Journal of Biological Chemistry, vol. 279, pp. 2377 - 2382, http://dx.doi.org/10.1074/jbc.M308254200
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Fahmy R; Khachigian LM, 2004, 'Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth', Nucleic Acids Research, vol. 32, pp. 2281 - 2285, http://dx.doi.org/10.1093/nar/gkh543
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Hanratty C; Murrell MJ; Khachigian LM; Tsao P; Ward M, 2004, 'Low flow promotes instent intimal hyperplasia: Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate', Atherosclerosis, vol. 177, pp. 269 - 274, http://dx.doi.org/10.1016/j.atherosclerosis.2004.07.016
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Protein-protein interaction between Fli-1 and GATA-1 mediatessynergistic expression of megakaryocyte-specific genes throughcooperative DNA binding (vol 23, pg 3427, 2003)', Molecular and Cellular Biology, vol. 24, pp. 5088 - 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Zhang GS; Dass CR; Sun L; Khachigian LM, 2004, 'DNAZYMES TARGETING C-JUN BLOCK ENDOTHELIAL PROLIFERATION, MIGRATION, TUBULE FORMATION, ANGIOGENESIS AND SOLID TUMOR GROWTH', Cardiovascular Pathology, vol. 13, pp. 131 - 131, http://www.sciencedirect.com/science/article/B6T13-4C88SSS-FR/2/5289ac8546a33c5e6f75f4effe492cdc
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Khachigian LM, 2004, 'Deoxyribozymes as inhibitors of vascular smooth muscle cell growth', Current Pharmaceutical Biotechnology, vol. 5, pp. 337 - 339, http://dx.doi.org/10.2174/1389201043376788
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Khachigian LM, 2004, 'DNAzymes as molecular agents that manipulate Egr-1 gene expression', Biochemical Pharmacology, vol. 68, pp. 1023 - 1025, http://dx.doi.org/10.1016/j.bcp.2004.03.042
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Khachigian LM, 2004, 'Oxidative stress and endothelial dysfunction', Endothelium - Journal of Endothelial Cell Research, vol. 11, pp. 77 - 78, http://dx.doi.org/10.1080/10623320490492339
    Journal articles | 2004
    Professor Levon Michael Khachigian
    Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Erratum: Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (Molecular and Cellular Biology (2003) 23, 10 (3427-3441))', Molecular and Cellular Biology, vol. 24, pp. 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Kavurma MM; Khachigian LM, 2003, 'Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation', Journal of Biological Chemistry, vol. 278, pp. 32537 - 32543, http://dx.doi.org/10.1074/jbc.M305650200
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Kavurma MM; Khachigian LM, 2003, 'Signaling and transcriptional control of Fas ligand gene expresion', Cell death and differentiation, vol. 10, pp. 36 - 44, http://dx.doi.org/10.1038/sj.cdd.4401179
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Zhang C; Kavurma MM; Lai A; Khachigian LM, 2003, 'Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF1/Cip1 promoter', Journal of Biological Chemistry, vol. 278, pp. 27903 - 27909, http://dx.doi.org/10.1074/jbc.M304328200
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Francis DJ; Parish CR; McGarry M; Santiago FS; Lowe HC; Brown KJ; Bingley JA; Hayward IP; Cowden WB; Campbell JH; Campbell GR; Chesterman CN; Khachigian LM, 2003, 'Blockade of Vascular Smooth Muscle Cell Proliferation and Intimal Thickening After Balloon Injury by the Sulfated Oligosaccharide PI-88', Circulation Research, vol. 92, pp. 70 - 77
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Burkhart CA; Cheng AJ; Madafiglio J; Kavallaris M; Mili M; Marshall GM; Weiss WA; Khachigian LM; Norris MD; Haber M, 2003, 'Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma', Journal of National Cancer Institute, vol. 95, pp. 1394 - 1403, http://dx.doi.org/10.1093/jnci/djg045
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Eisbacher M; Holmes ML; Newton A; Hogg PJ; Crossley M; Chong BH; Khachigian LM, 2003, 'Protein-protein interaction between Fli-1 and GATA 1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding', Molecular and Cellular Biology, vol. 23, pp. 3427 - 3441, http://dx.doi.org/10.1128/MCB.23.10.3427-3441.2003
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Fahmy R; Dass CR; Sun L; Chesterman CN; Khachigian LM, 2003, 'Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumour growth', Nature Medicine, vol. 9, pp. 1026 - 1032, http://dx.doi.org/10.1038/nm905
    Journal articles | 2003
    Professor Levon Michael Khachigian
    De Mestre AM; Khachigian LM; Santiago FS; Staykova MA; Hulett MD, 2003, 'Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1', Journal of Biological Chemistry, vol. 278, pp. 50377 - 50385, http://dx.doi.org/10.1074/jbc.M310154200
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Kavurma MM; Khachigian LM, 2003, 'ERK, JNK, and p38 MAP Kinases Differentially Regulate Proliferation and Migration of Phenotypically Distinct Smooth Muscle Cell Subtypes', Journal of Cellular Biochemistry, vol. 89, pp. 289 - 300, http://dx.doi.org/10.1002/jcb.10497
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Lowe HC; Jang IK; Khachigian LM, 2003, 'Animal models of vulnerable plaque', Thrombosis and Haemostasis, vol. 90, pp. 774 - 780
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Ward MR; Hanratty CG; Murrell M; Khachigian L; Tsao PS, 2003, 'Low flow increases stent restenosis. Comparison with flow-dependent lumen loss after angioplasty and effects of the antioxidant PDTC', Heart, Lung and Circulation, vol. 12, pp. A73 - A74, http://dx.doi.org/10.1046/j.1443-9506.2003.02873.x
    Journal articles | 2003
    Professor Levon Michael Khachigian
    Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and Emerging Therapies in Cardiology and Haematology', Current Drug Targets, vol. 3, pp. 101 - 103, http://dx.doi.org/10.2174/1568006033481465
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Khachigian LM; Fahmy R; Zhang GS; Bobryshev YV; Kaniaros A, 2002, 'c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun', The Journal of Biological Chemistry, vol. 277, pp. 22985 - 22991, http://dx.doi.org/10.1074/jbc.M200977200
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Kavurma MM; Bobryshev YV; Khachigian LM, 2002, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1', The Journal of Biological Chemistry, vol. 277, pp. 36244 - 36252, http://dx.doi.org/10.1074/jbc.M200463200
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Lowe HC; Oesterle SN; Khachigian LM, 2002, 'Coronary In-Stent Restenosis: Current Status and Future Strategies', Journal of the American College of Cardiology, vol. 39, pp. 183 - 193, http://dx.doi.org/10.1016/S0735-1097(01)01742-9
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Rafty LA; Santiago FS; Khachigian LM, 2002, 'NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter', European Molecular Biology Organization, vol. 21, pp. 334 - 343, http://dx.doi.org/10.1093/emboj/21.3.334
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Khachigian LM, 2002, 'Catalytic Antisense DNA Molecules Targeting Egr-1 Inhibit Neointima Formation following Permanent Ligation of Rat Common Carotid Arteries', Thrombosis and Haemostasis, vol. 87, pp. 134 - 140
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Lowe HC; Khachigian LM, 2002, 'Coating stents with antirestenotic drugs: the blunderbuss or the magic bullet?', Circulation, vol. 105, http://dx.doi.org/10.1161/circ.105.4.e29
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Fahmy R; Khachigian LM, 2002, 'Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury', Journal of Cellular Biochemistry, vol. 84, pp. 575 - 582, http://dx.doi.org/10.1002/jcb.10057
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Khachigian LM, 2002, 'DNAzymes: cutting a path to a new class of therapeutics', Current Opinion in Molecular Therapeutics, vol. 4, pp. 119 - 121
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Lowe HC; Burkoff D; Khachigian LM; MacNeill BD; Hayase M; Oesterle SN, 2002, 'Beyond angioplasty: novel developments in interventional cardiology', Internal Medicine Journal, vol. 32, pp. 470 - 474, http://dx.doi.org/10.1046/j.1445-5994.2002.00261.x
    Journal articles | 2002
    Professor Levon Michael Khachigian
    MacNeill BD; James B; Chesterman CN; Khachigian LM, 2002, 'Overstretch stent injury to the rat aorta leads to in-stent restenosis', American Journal of Cardiology, vol. 89, pp. 1010, http://dx.doi.org/10.1016/S0002-9149(02)02264-6
    Journal articles | 2002
    Professor Levon Michael Khachigian
    Rafty LA; Khachigian LM, 2002, 'von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter', Journal of Cellular Biochemistry, vol. 85, pp. 490 - 495, http://dx.doi.org/10.1002/jcb.10152
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Kavurma MM; Santiago FS; Bonfoco E; Khachigian LM, 2001, 'Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement', The Journal of Biological Chemistry, vol. 276, pp. 4964 - 4971, http://dx.doi.org/10.1074/jbc.M009251200
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Lowe HC; Fahmy R; Kavurma MM; Baker A; Chesterman CN; Khachigian LM, 2001, 'Catalytic Oligodeoxynucleotides Define a Key Regulatory Role for Early Growth Response Factor-1 in the Porcine Model of Coronary In-Stent Restenosis', Circulation Research, vol. 89, pp. 670 - 677, http://dx.doi.org/10.1161/hh2001.097867
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical proten kinase C-', Nucleic Acids Research, vol. 29, pp. 1027 - 1033
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Santiago FS; Khachigian LM, 2001, 'Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.', Molecular Medicine, vol. 79, pp. 695 - 706, http://dx.doi.org/10.1007/s001090100272
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Gousseva N; Kugathasan K; Chesterman CN; Khachigian LM, 2001, 'Early Growth Response Factor-1 Mediates Insulin-Inducible Vascular Endothelial Cell Proliferation and Regrowth After Injury', Journal of Cellular Biochemistry, vol. 81, pp. 523 - 534, http://dx.doi.org/10.1002/1097-4644(20010601)81:3<523::AID-JCB1066>3.0.CO;2-E
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Khachigian LM, 2001, 'Catalytic oligonucleotides targeting Egr-1 as potential inhibitors of in-stent restenosis', Annals of the New York Academy of Sciences, vol. 947, pp. 412 - 415, http://dx.doi.org/10.1111/j.1749-6632.2001.tb03975.x
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Santiago FS; Lowe HC; Bobryshev YV; Khachigian LM, 2001, 'Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.', The Journal of Biological Chemistry, vol. 276, pp. 41143 - 41149, http://dx.doi.org/10.1074/jbc.M104913200
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Lowe HC; Kumar RK; Chesterman CN; Fahmy R; Khachigian LM, 2001, 'Coronary Stent Thrombosis: Insights from the Porcine Coronary Stent Model', Journal of Thrombosis and Thrombolysis, vol. 86, pp. 937 - 938
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2001, 'Acute Local Release of Fibroblast Growth Factor 2 but not Transforming Growth Factor B1 following Coronary Stenting', Journal of Thrombosis and Thrombolysis, vol. 85, pp. 574 - 576
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Rat Aortic Stenting: Toward a Simple Model of In-Stent Restenosis', American Journal of Cardiology, vol. 88, pp. 720 - 721, http://dx.doi.org/10.1016/S0002-9149(01)01795-7
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Does Thrombus Contribute to In-stent Restenosis in the Porcine Coronary Stent Model?', Journal of Thrombosis and Thrombolysis, vol. 85, pp. 1117 - 1118
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Lowe HC; Fahmy R; Chesterman CN; Khachigian LM, 2001, 'Catalytic oligodeoxynucleotides targeting the human transcription factor EGR-1 as inhibitors of restenosis', CIRCULATION, vol. 104, pp. 265 - 265, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171895001261&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Khachigian LM, 2001, 'Single-stranded catalytic dna as potential therapeutic agents in vascular disease', Today's Life Science, vol. 13, pp. 30 - 31
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Eisbacher M; Newton A; Holmes ML; Khachigian LM; Crossley M; Chong BH, 2001, 'The protein-protein interaction between FLI-1 and GATA-1 is crucial for expression of the megakaryocyte-specific gene Glycoprotein IX.', BLOOD, vol. 98, pp. 286A - 286A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2001
    Professor Levon Michael Khachigian
    Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation mediates inducible platelet-derived growth factor B-chain gene expression: Phosphorylation mediated by atypical protein kinase C-zeta', FASEB JOURNAL, vol. 15, pp. A1185 - A1185, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167454202722&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Tapsall JW; Khachigian LM, 2000, 'Induction of platelet-derived growth factor B-chain expression by transforming growth factor-b involves transactivation by smads', The Journal of Biological Chemistry, vol. 275, pp. 16709 - 16716, http://dx.doi.org/10.1074/jbc.275.22.16709
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet ?-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells.', Blood, vol. 95, pp. 3094 - 3101
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Khachigian LM, 2000, 'Catalytic DNAs as potential therapeutic agents and sequent-specific molecular tools to dissect biological function', Journal of Clinical Investigation, vol. 106, pp. 1189 - 1195, http://dx.doi.org/10.1172/JCI11620
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Murray BJ; Chong BH; Chesterman CN; Khachigian LM, 2000, 'Intracoronary blood sampling using the multifunction probing catheter does not cause platelet activation', Journal of Invasive Cardiology, vol. 12, pp. 144 - 146
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Larkin L; Khachigian LM; Jessup W, 2000, 'Regulation of apolipoprotein E production in macrophages', International Journal of Molecular Medicine, vol. 6, pp. 253 - 258
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Khachigian LM; Takuwa Y; Collins TF, 2000, 'Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression', Molecular and Cellular Biochemistry, vol. 212, pp. 183 - 186
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Rafty LA; Khachigian LM, 2000, 'Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression', The Journal of Biological Chemistry, vol. 275, pp. 11478 - 11483, http://dx.doi.org/10.1074/jbc.275.15.11478
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Khachigian LM, 2000, 'Neointimal formation following rat carotid angioplasty is inhibited by a novel catalytic DNA molecule targeting the transcription factor EGR-1', Heart, Lung and Circulation, vol. 9, pp. A90 - A90, http://dx.doi.org/10.1046/j.1443-9506.2000.06012.x
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Costandi M; Chesterman CN; Khachigian LM, 2000, 'Human vascular injury triggers fibroblast growth factor 2 (FGF 2) release. Neointima formation in vitro is inhibited by novel catalytic DNA molecules targeting human EGR-1', Heart, Lung and Circulation, vol. 9, pp. A95 - A95, http://dx.doi.org/10.1046/j.1443-9506.2000.0622x.x
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Chong BH; Eisbacher M; Khin TH; Khachigian LM, 2000, 'Inducible expression of GPIX by PMA and TPO in megakaryocytic cells requires an intact Ets site and upstream activation of ERK.', BLOOD, vol. 96, pp. 672A - 672A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256102891&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2000, 'Acute local release of fibroblast growth factor-2, but not transforming growth factor-beta(1), following coronary stenting', CIRCULATION, vol. 102, pp. 732 - 732, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000090072303532&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'Immobilized hyaluronic acid as a thromboresistant coating for cardiovascular devices', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2000
    Professor Levon Michael Khachigian
    Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'A novel catalytic DNA molecule targeting the transcription factor Egr-1 inhibits neointimal formation following rat carotid angioplasty', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Khachigian LM; Santiago FS; Rafty LA; Onza CL; Delbridge G; Bobik A; Collins TF; Johnson AG, 1999, 'GC Factor 2 represses plateletderived growth factor Achain gene transcription and is itself induced by arterial injury', Circulation Research, vol. 84, pp. 1258 - 1267, http://dx.doi.org/10.1161/01.RES.84.11.1258
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Silverman ES; Khachigian LM; Santiago FS; Williams A; Lindner V; Collins TF, 1999, 'Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury.', American Journal of Pathology, vol. 155, pp. 1311 - 1317, http://dx.doi.org/10.1016/S0002-9440(10)65233-9
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker AT; Atkins D; Khachigian LM, 1999, 'New DNA enzyme targeting Egr1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury', Nature Medicine, vol. 5, pp. 1264 - 1269, http://dx.doi.org/10.1038/15215
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Santiago FS; Lowe HC; Day FL; Chesterman CN; Khachigian LM, 1999, 'Early growth response factor1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor2.', American Journal of Pathology, vol. 154, pp. 937 - 944, http://dx.doi.org/10.1016/S0002-9440(10)65341-2
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'Erratum: New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (Nature Medicine (1999) 5 (1264-1269))', Nature Medicine, vol. 5, pp. 1438, http://dx.doi.org/10.1038/71020
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Santiago FS; Atkins D; Khachigian LM, 1999, 'Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr1/NGFIAdependent.', American Journal of Pathology, vol. 155, pp. 897 - 905, http://dx.doi.org/10.1016/S0002-9440(10)65189-9
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (vol 5, pg 1264, 1999)', NATURE MEDICINE, vol. 5, pp. 1438 - 1438, http://dx.doi.org/10.1038/71020
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Lowe HC; Chesterman CN; Khachigian LM, 1999, 'Left main coronary artery stenosis after percutaneous transluminal coronary angioplast: Importance of remaining `Minimally Invasive`', Catheterization and Cardiovascular Interventions, vol. 46, pp. 254 - 255
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Day FL; Rafty LA; Chesterman CN; Khachigian LM, 1999, 'Angiotensin II (ATII)inducible plateletderived growth factor Achain gene expression is p42/44 extracellular signalregulated kinase1/2 and Egr1dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII a', The Journal of Biological Chemistry, vol. 274, pp. 23726 - 23733, http://dx.doi.org/10.1074/jbc.274.34.23726
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Khachigian LM, 1999, 'The imtimacies of blood vessel injury.', Today's Life Science, vol. 11, pp. 74 - 78
    Journal articles | 1999
    Professor Levon Michael Khachigian
    Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.', FASEB JOURNAL, vol. 13, pp. A42 - A42, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033300240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1998
    Professor Levon Michael Khachigian
    Khachigian LM; Collins TF, 1998, 'Early growth response factor-1: a pleiotropic mediator of inducible gene expression.', Journal of Molecular Medicine - Jmm, vol. 76, pp. 613 - 616, http://dx.doi.org/10.1007/s001090050258
    Journal articles | 1998
    Professor Levon Michael Khachigian
    Sumpio RE; Du W; Galagher G; Wang H; Khachigian LM; Collins TF; Gimbrone MA; Resnick N, 1998, 'Regulation of PDGF-B in endothelial cells exposed to cyclic strain.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 18, pp. 349 - 355, http://dx.doi.org/10.1161/01.ATV.18.3.349
    Journal articles | 1998
    Professor Levon Michael Khachigian
    Rafty LA; Khachigian LM, 1998, 'Zinc finger transcription factors mediate high constitutive PDGF-B expression in smooth muscle cells derived from aortae of newborn rats.', The Journal of Biological Chemistry, vol. 273, pp. 5758 - 5764, http://dx.doi.org/10.1074/jbc.273.10.5758
    Journal articles | 1998
    Professor Levon Michael Khachigian
    Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1998, 'Endothelial injury triggers FGF-2 release and a signaling cascade involving MAPK and Egr-1.', FASEB JOURNAL, vol. 12, pp. A467 - A467, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006402706&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1998
    Professor Levon Michael Khachigian
    Santiago FS; Atkins D; Khachigian LM, 1998, 'Antisense oligonucleotides directed against Egr-1 inhibit vascular smooth muscle cell proliferation.', FASEB JOURNAL, vol. 12, pp. A189 - A189, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006401100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Resnick N; Yahav H; Khachigian LM; Collins T; Anderson KR; Dewey FC; Gimbrone MA, 1997, 'Endothelial gene regulation by laminar shear stress', Advances in Experimental Medicine and Biology, vol. 430, pp. 155 - 164, http://dx.doi.org/10.1007/978-1-4615-5959-7_13
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Khachigian LM; Collins TF, 1997, 'Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium', Circulation Research, vol. 81, pp. 457 - 461, http://dx.doi.org/10.1161/01.RES.81.4.457
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Khachigian LM; Anderson KJ; Halnon NJ; Gimbrone MA; Resnick N; Collins TF, 1997, 'Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 17, pp. 2280 - 2286, http://dx.doi.org/10.1161/01.ATV.17.10.2280
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Silverman ES; Khachigian LM; Lindner V; Williams A; Collins TF, 1997, 'Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3', American Journal of Physiology - Cell Physiology, vol. 273, pp. H1415 - H1426
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Yang M; Khachigian LM; Hicks C; Chesterman CN; Chong BH, 1997, 'Identification of PDGF receptors on human megakaryocytes and megakarocytic cell lines', Thrombosis and Haemostasis, vol. 78, pp. 892 - 896
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Gimbrone MA; Resnick N; Nagel T; Khachigian LM; Collins T; Topper JN, 1997, 'Hemodynamics, endothelial gene expression, and atherogenesis', Annals of the New York Academy of Sciences, vol. 811, pp. 1 - 11, http://dx.doi.org/10.1111/j.1749-6632.1997.tb51983.x
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Khachigian LM; Collins TF; Fries JW, 1997, 'N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo', American Journal of Pathology, vol. 151, pp. 1225 - 1229
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Delbridge G; Khachigian LM, 1997, 'FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1', Circulation Research, vol. 81, pp. 282 - 288, http://dx.doi.org/10.1161/01.RES.81.2.282
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Khachigian LM; Dixon GJ; Huang XF; Catts SV; Hickie IB; Wakefield D, 1997, 'Molecular biology and the major psychoses', Australian and New Zealand Journal of Psychiatry, vol. 31, pp. 12 - 16, http://dx.doi.org/10.3109/00048679709073794
    Journal articles | 1997
    Professor Levon Michael Khachigian
    Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1997, 'Endothelial injury and transcriptional activation: bFGF induction of Egr-1 and PDGF-A', ATHEROSCLEROSIS, vol. 134, pp. 265 - 265, http://dx.doi.org/10.1016/S0021-9150(97)89392-6
    Journal articles | 1996
    Professor Levon Michael Khachigian
    Khachigian LM; Anderson KR; Halnon NJ; Gimbrone MA; Resnick N; Collins T, 1996, 'Shear-induced endothelial pdgf-a chain gene expression involves EGR-1', FASEB Journal, vol. 10
    Journal articles | 1996
    Professor Levon Michael Khachigian
    Khachigian LM; Lindner V; Williams A; Collins TF, 1996, 'Egr-1-induced endothelial gene expression: a common theme in vascular injury', Science, vol. 271, pp. 1427 - 1431, http://dx.doi.org/10.1126/science.271.5254.1427
    Journal articles | 1996
    Professor Levon Michael Khachigian
    Field ST; Khachigian LM; Sleigh MJ; Yang G; Hogg PJ; Chesterman CN, 1996, 'Extracellular matrix as a source of mitogenically active platelet-derived growth factor', Journal of Cellular Physiology, vol. 168, pp. 322 - 332, http://dx.doi.org/10.1002/(SICI)1097-4652(199608)168:2<322::AID-JCP11>3.0.CO;2-5
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells', Journal of Biological Chemistry, vol. 270, pp. 27679 - 27686, http://dx.doi.org/10.1074/jbc.270.46.27679
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Khachigian LM; Resnick N; Gimbrone MA; Collins T, 1995, 'Nuclear factor-κB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress', Journal of Clinical Investigation, vol. 96, pp. 1169 - 1175, http://dx.doi.org/10.1172/JCI118106
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the PDGF A-chain proximal promoter in cultured vascular endothelial cells.', BLOOD, vol. 86, pp. 1246 - 1246, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TH91001248&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Neish AS; Khachigian LM; Baichwal VR; Park A; Collins TF, 1995, 'Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1', The Journal of Biological Chemistry, vol. 270, pp. 28903 - 28908, http://dx.doi.org/10.1074/jbc.270.48.28903
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Williams A; Khachigian LM; Shows T; Collins TF, 1995, 'Isolation and characterisation of a novel zinc-finger protein with transcriptional repressor activity', The Journal of Biological Chemistry, vol. 270, pp. 22143 - 22152, http://dx.doi.org/10.1074/jbc.270.38.22143
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Khachigian LM; Collins T; Fries JWU, 1995, 'Nuclear factor-κB mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells', Biochemical and Biophysical Research Communications, vol. 206, pp. 462 - 467, http://dx.doi.org/10.1006/bbrc.1995.1065
    Journal articles | 1995
    Professor Levon Michael Khachigian
    Khachigian LM; Field SL; Crouch R; Chesterman CN, 1995, 'Platelet-derived growth factor A-chain synthetic peptide inhibits human glioma xenograft proliferation in nude mice', Anticancer Research, vol. 15, pp. 337 - 341
    Journal articles | 1995
    Professor Levon Michael Khachigian
    KHACHIGIAN LM; RESNICK N; GIMBRONE MA; COLLINS T, 1995, 'NUCLEAR FACTOR-KAPPA-B INTERACTS FUNCTIONALLY WITH THE SHEAR-STRESS-RESPONSE-ELEMENT IN THE PLATELET-DERIVED GROWTH-FACTOR B-CHAIN PROMOTER', FASEB JOURNAL, vol. 9, pp. A412 - A412, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98702410&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1994
    Professor Levon Michael Khachigian
    Khachigian LM; Fries JWU; Benz MW; Bonthron DT; Collins T, 1994, 'Novel cis-acting elements in the human platelet-derived growth factor B- chain core promoter that mediate gene expression in cultured vascular endothelial cells', Journal of Biological Chemistry, vol. 269, pp. 22647 - 22656
    Journal articles | 1994
    Professor Levon Michael Khachigian
    Khachigian LM; Chesterman CN, 1994, 'Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6', Peptides, vol. 15, pp. 133 - 137, http://dx.doi.org/10.1016/0196-9781(94)90181-3
    Journal articles | 1994
    Professor Levon Michael Khachigian
    KHACHIGIAN LM; BENZ MW; NEISH AS; BONTHRON DT; COLLINS T, 1994, 'NOVEL DNA-BINDING ELEMENTS IN THE PROMOTER OF HUMAN PLATELET-DERIVED GROWTH-FACTOR B-CHAIN GENE', FASEB JOURNAL, vol. 8, pp. A392 - A392, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994ND19602268&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1993
    Professor Levon Michael Khachigian
    Khachigian LM; Chesterman CN, 1993, 'Platelet-derived growth factor and its receptor: Structure and roles in normal growth and pathology', Platelets, vol. 4, pp. 304 - 315, http://dx.doi.org/10.3109/09537109309013233
    Journal articles | 1993
    Professor Levon Michael Khachigian
    KHACHIGIAN LM; SLEIGH MJ; CHESTERMAN CN, 1993, 'PLATELET-DERIVED GROWTH FACTOR-A-CHAIN EXON-6 PRODUCT ASSOCIATES WITH EXTRACELLULAR HEPARIN-LIKE GLYCOSAMINOGLYCANS', THROMBOSIS AND HAEMOSTASIS, vol. 69, pp. 972 - 972, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LT57701547&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1992
    Professor Levon Michael Khachigian
    Khachigian LM; Evin G; Morgan FJ; Owensby DA; Chesterman CN, 1992, 'A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine (J. Immunol. Methods 140 (1991) 249-258)', Journal of Immunological Methods, vol. 149, pp. 267, http://dx.doi.org/10.1016/0022-1759(92)90259-v
    Journal articles | 1992
    Professor Levon Michael Khachigian
    Khachigian LM; Owensby DA; Chesterman CN, 1992, 'A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth factors', Journal of Biological Chemistry, vol. 267, pp. 1660 - 1666
    Journal articles | 1992
    Professor Levon Michael Khachigian
    Khachigian LM; Chesterman CN, 1992, 'Platelet-derived growth factor and alternative splicing: A review', Pathology, vol. 24, pp. 280 - 290, http://dx.doi.org/10.3109/00313029209068882
    Journal articles | 1992
    Professor Levon Michael Khachigian
    Khachigian LM; Chesterman CN, 1992, 'Synthetic peptides representing the alternatively spliced exon of the platelet-derived growth factor A-chain modulate mitogenesis stimulated by normal human serum and several growth factors', Journal of Biological Chemistry, vol. 267, pp. 7478 - 7482
    Journal articles | 1992
    Professor Levon Michael Khachigian
    Journal articles | 1992
    Professor Levon Michael Khachigian
    Khachigian LM; Owensby DA; Chesterman CN, 1992, 'Erratum: A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth factors (Journal of Biological Chemistry (1992) 267 (1660-1666))', Journal of Biological Chemistry, vol. 267, pp. 6449
    Journal articles | 1991
    Professor Levon Michael Khachigian
    Khachigian LM; Evin G; Morgan FJ; Owensby DA; Chesterman CN, 1991, 'A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine', Journal of Immunological Methods, vol. 140, pp. 249 - 258, http://dx.doi.org/10.1016/0022-1759(91)90378-S
  • Conference Papers | 2017
    Professor Levon Michael Khachigian
    Billah M; Ridiandries A; Khachigian L; Dona A; Bhindi R, 2017, 'Autophagy is Essential for Remote Preconditioning Induced Cardioprotection and May Involve JAK-STAT Pathway for Autophagy Activation', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, Portland, OR, presented at Basic Cardiovascular Sciences Scientific Sessions of the American-Heart-Association - Pathways to Cardiovascular Therapeutics, Portland, OR, 10 July 2017 - 13 July 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000520552700360&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Levon Michael Khachigian
    Khachigian LM, 2016, 'New insights on the regulatory roles of early growth response-1 in the reparative response to vascular injury', in INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBL LTD, Vol. 38, pp. S79 - S79, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383733000298&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Professor Levon Michael Khachigian
    Sheahan AV; Khachigian LM, 2013, 'Abstract 3121: c-Jun as a target in pancreatic cancer.', in Molecular and Cellular Biology, American Association for Cancer Research, presented at Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am2013-3121
    Conference Papers | 2013
    Professor Levon Michael Khachigian
    Yee GPC; De Souza PL; Khachigian LM, 2013, 'Reducing invasion potential of cervical cancer cells via targeted knockdown of c-Jun', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, 31 May 2013 - 04 June 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419605150&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Levon Michael Khachigian
    Cho E; Moloney FJ; Cai H; Au-Yeung A; China C; Scolyer RA; Francis DJ; Halliday GM; Khachigian LM, 2012, 'First-in-Human Trial of Dz13 DNAzyme Targeting c-jun in Patients with Basal Cell Carcinoma', in JOURNAL OF INVESTIGATIVE DERMATOLOGY, NATURE PUBLISHING GROUP, Venice, ITALY, pp. S66 - S66, presented at 42nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Venice, ITALY, 07 September 2012 - 10 September 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000307814000367&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Professor Levon Michael Khachigian
    Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', in VASCULAR PHARMACOLOGY, ELSEVIER SCIENCE INC, Krakow, POLAND, pp. 335 - 336, presented at 6th European Meeting on Vascular Biology and Medicine (EMVBM), Krakow, POLAND, 21 September 2011 - 24 September 2011, http://dx.doi.org/10.1016/j.vph.2011.08.088
    Conference Papers | 2008
    Professor Levon Michael Khachigian
    Khachigian LM, 2008, 'IMMEDIATE-EARLY GENES AS MASTER SWITCHES IN DISEASE', in Cell Biology International, Academic Press Ltd Elsevier Science Ltd, London, England, pp. S3 - S3, presented at Cell Biology International, http://dx.doi.org/10.1016/j.cellbi.2008.01.018
    Conference Papers | 2006
    Professor Levon Michael Khachigian
    Bhindi R; Khachigian LM; Lowe HC, 2006, 'Egr-1 targeting DNAzymes reduce myocardial infarct size following ischaemia-reperfusion', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Barcelona, SPAIN, pp. 409 - 409, presented at 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Barcelona, SPAIN, 02 September 2006 - 06 September 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240668402465&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Professor Levon Michael Khachigian
    Murrell MJ; Khachigian LM; Tsao P; Ward MR, 2003, 'The effect of oxidant stress, injury and flow on c-jun and egr-1 expression', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, WASHINGTON, D.C., pp. A20 - A20, presented at 4th Annual Conference on Arteriosclerosis Thrombosisand Vascular Biology, WASHINGTON, D.C., 08 May 2003 - 10 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000182742500140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Professor Levon Michael Khachigian
    Eisbacher M; Holmes ML; Hogg PJ; Newton A; Khachigian LM; Crossley M; Chong BH, 2003, 'Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA-binding', in Journal of Thrombosis and Haemostasis, Blackwell Publishing Ltd, Oxford, England, pp. 357 - 357, presented at XIXth Congress of the International Society on Thrombosis and Haematosis, Birmingham, England, 12 July 2003 - 18 July 2003
    Conference Papers | 2002
    Professor Levon Michael Khachigian
    Khachigian LM, 2002, 'Insulin and vascular growth regulation by transcription', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A27 - A27, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2002
    Professor Levon Michael Khachigian
    Khachigian LM, 2002, 'Control of immediate-early transcription factor expression in injured arteries', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A12 - A12, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Patents | 1999
    Professor Levon Michael Khachigian
    Khachigian LM, 1999, Treatment of cancer, Patent No.
    Patents | 1999
    Professor Levon Michael Khachigian
    Khachigian LM, 1999, Treatment of asthma, Patent No.
    Patents | 1999
    Professor Levon Michael Khachigian
    Khachigian LM; Atkins D; Baker AT, 1999, Catalytic molecules, Patent No.
    Conference Papers | 1995
    Professor Levon Michael Khachigian
    Khachigian LM; Resnick N; Gimbrone MA; Collins TF, 1995, 'Nuclear factor-kB interacts functionally with the platelet-derived growth factor B-chain promoter', in Journal of Clinical Investigation, American Society Clinical Investigation Inc, Ann Arbor, MI, USA, presented at Experimental Biology Meeting 1995, Atlanta, Georgia USA, 08 April 1995 - 12 April 1995

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