Dr Lin Xiao

Conjoint Lecturer

PhD, University of North Carolina, Chapel Hill, USA

Bachelor of Science, La Trobe University, Melbourne, Australia

Bachelor of Nursing, University of Sydney, Australia          

Medicine & Health
School of Clinical Medicine

Dr. Xiao is a Research Officer at Children's Cancer Institute and a Cancer Institute NSW Early Career Fellow. 

  • Journal articles | 2021
    Xiao L; Somers K; Murray J; Pandher R; Karsa M; Ronca E; Bongers A; Terry R; Ehteda A; Gamble LD; Issaeva N; Leonova KI; O’Connor A; Mayoh C; Venkat P; Quek H; Brand J; Kusuma FK; Pettitt JA; Mosmann E; Kearns A; Eden G; Alfred S; Allan S; Zhai L; Kamili A; Gifford AJ; Carter DR; Henderson MJ; Fletcher JI; Marshall G; Johnstone RW; Cesare AJ; Ziegler DS; Gudkov AV; Gurova KV; Norris MD; Haber M, 2021, 'Dual targeting of chromatin stability by the curaxin CBL0137 and histone deacetylase inhibitor panobinostat shows significant preclinical efficacy in neuroblastoma', Clinical Cancer Research, vol. 27, pp. 4338 - 4352, http://dx.doi.org/10.1158/1078-0432.CCR-20-2357
    Journal articles | 2021
    Xiao L; Yeung H; Haber M; Norris MD; Somers K, 2021, 'Immunometabolism: A ‘Hot’ Switch for ‘Cold’ Pediatric Solid Tumors', Trends in Cancer, vol. 7, pp. 751 - 777, http://dx.doi.org/10.1016/j.trecan.2021.05.002
    Journal articles | 2019
    Gamble LD; Purgato S; Murray J; Xiao L; Yu DMT; Hanssen KM; Giorgi FM; Carter DR; Gifford AJ; Valli E; Milazzo G; Kamili A; Mayoh C; Liu B; Eden G; Sarraf S; Allan S; Giacomo SD; Flemming CL; Russell AJ; Cheung BB; Oberthuer A; London WB; Fischer M; Trahair TN; Fletcher JI; Marshall GM; Ziegler DS; Hogarty MD; Burns MR; Perini G; Norris MD; Haber M, 2019, 'Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma', Science Translational Medicine, vol. 11, http://dx.doi.org/10.1126/scitranslmed.aau1099
    Journal articles | 2019
    McCann JV; Xiao L; Kim DJ; Khan OF; Kowalski PS; Anderson DG; Pecot CV; Azam SH; Parker JS; Tsai YS; Wolberg AS; Turner SD; Tatsumi K; Mackman N; Dudley AC, 2019, 'Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1', Journal of Clinical Investigation, vol. 129, pp. 1654 - 1670, http://dx.doi.org/10.1172/JCI123106
    Journal articles | 2018
    Kim DJ; Dunleavey JM; Xiao L; Ollila DW; Troester MA; Otey CA; Li W; Barker TH; Dudley AC, 2018, 'Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition', British Journal of Cancer, vol. 118, pp. 1359 - 1368, http://dx.doi.org/10.1038/s41416-018-0072-3
    Journal articles | 2017
    Rao K; Sethi K; Ischia J; Gibson L; Galea L; Xiao L; Yim M; Chang M; Papa N; Bolton D; Shulkes A; Baldwin GS; Patel O, 2017, 'Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0180028
    Journal articles | 2017
    Xiao L; Dudley AC, 2017, 'Fine-tuning vascular fate during endothelial–mesenchymal transition', Journal of Pathology, vol. 241, pp. 25 - 35, http://dx.doi.org/10.1002/path.4814
    Journal articles | 2016
    Chang M; Xiao L; Shulkes A; Baldwin GS; Patel O, 2016, 'Zinc ions mediate gastrin expression, proliferation, and migration downstream of the cholecystokinin-2 receptor', Endocrinology, vol. 157, pp. 4706 - 4719, http://dx.doi.org/10.1210/en.2016-1270
    Journal articles | 2016
    Lucitti JL; Sealock R; Buckley BK; Zhang H; Xiao L; Dudley AC; Faber JE, 2016, 'Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke', Stroke, vol. 47, pp. 3022 - 3031, http://dx.doi.org/10.1161/STROKEAHA.116.014160
    Journal articles | 2015
    Xiao L; Kim DJ; Davis CL; McCann JV; Dunleavey JM; Vanderlinden AK; Xu N; Pattenden SG; Frye SV; Xu X; Onaitis M; Monaghan-Benson E; Burridge K; Dudley AC, 2015, 'Tumor endothelial cells with distinct patterns of TGFβ-driven endothelial-to-mesenchymal transition', Cancer Research, vol. 75, pp. 1244 - 1254, http://dx.doi.org/10.1158/0008-5472.CAN-14-1616
    Journal articles | 2015
    Xiao L; McCann JV; Dudley AC, 2015, 'Isolation and culture expansion of tumor-specific endothelial cells', Journal of Visualized Experiments, vol. 2015, http://dx.doi.org/10.3791/53072
    Journal articles | 2014
    Dunleavey JM; Xiao L; Thompson J; Kim MM; Shields JM; Shelton SE; Irvin DM; Brings VE; Ollila DW; Brekken RA; Dayton PA; Melero-Martin JM; Dudley AC, 2014, 'Vascular channels formed by subpopulations of PECAM1 + melanoma cells', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6200
    Journal articles | 2014
    Xiao L; Harrell JC; Perou CM; Dudley AC, 2014, 'Identification of a stable molecular signature in mammary tumor endothelial cells that persists in vitro', Angiogenesis, vol. 17, pp. 511 - 518, http://dx.doi.org/10.1007/s10456-013-9409-y
    Journal articles | 2013
    Ranasinghe WKB; Xiao L; Kovac S; Chang M; Michiels C; Bolton D; Shulkes A; Baldwin GS; Patel O, 2013, 'The Role of Hypoxia-Inducible Factor 1α in Determining the Properties of Castrate-Resistant Prostate Cancers', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0054251
    Journal articles | 2013
    Xiao L; Kovac S; Chang M; Shulkes A; Baldwin GS; Patel O, 2013, 'Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter', Journal of Molecular Endocrinology, vol. 52, pp. 29 - 42, http://dx.doi.org/10.1530/JME-13-0162
    Journal articles | 2012
    Xiao L; Kovac S; Chang M; Shulkes A; Baldwin GS; Patel O, 2012, 'Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF)', Endocrinology, vol. 153, pp. 3006 - 3016, http://dx.doi.org/10.1210/en.2011-2069
    Journal articles | 2010
    Kovac S; Xiao L; Shulkes A; Patel O; Baldwin GS, 2010, 'Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor', FEBS Letters, vol. 584, pp. 4413 - 4418, http://dx.doi.org/10.1016/j.febslet.2010.09.046
  • Conference Abstracts | 2019
    Haber M; Gamble L; Xiao L; Pandher R; Somers K; Murray J; Khan A; Yu D; Franshaw L; Burns MR; Tsoli M; Ehteda A; Cesare A; O'Connor A; Mussai F; de Santo C; Cheng P; Korotchkina L; Gurova K; Tyrrell V; Mould E; Lau L; Dong AKQ; Mayoh C; Arndt G; Barahona P; Failes T; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Gifford A; Grebert-Wade D; Kamili A; Kumar A; Nagabushan S; O'Brien T; Strong P; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Xie J; Evans K; Lock R; Chernova OB; Henderson M; Gudkov AV; Ekert P; Cowley MJ; Marshall GM; Ziegler DS; Norris MD, 2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

2021 – 2023       Cancer Australia Project Grant, co-CI

2018 – 2019       Neuroblastoma Australia Project Grant, CI

2020 – 2022       Cancer Institute NSW Early Career Fellowship

2019 – 2020       Tour de Cure Early Career Fellowship

My Research Supervision

Harrison Yeong (Honours Student, 2020)