Dr Lindsay Wu
Senior Res Fellow (NH&MRC)

Dr Lindsay Wu

BSc (Hons I) (Sydney), PhD (UNSW)

Medicine & Health
School of Medical Sciences

The Laboratory for Ageing Research is works on fundamental mechanisms and interventions that could maintain healthy ageing. These have immediate applications in other conditions, including slowing the decline in fertility with age, preventing the long-term adverse effects of chemotherapy treatment, and understanding why older people are so much more susceptible to coronavirus infection. 

The following projects and more are available for study at both the honours and PhD level...

  • New treatments to maintain female fertility during biological ageing and following chemotherapy treatment
  • Role of the pentose phosphate pathway and the enzyme glucose-6-phosphate dehydrogenase in reproductive ageing
  • DNA transposons in genome instability and the regulation of lifespan
  • New treatments to reduce the side effects of chemotherapy and improve long-term health in cancer survivors
  • Studies of the metabolism of nicotinamide adenine dinucleotide (NAD+)
  • Age-related changes in innate immunity and metabolism during coronavirus infection

Our lab uses molecular biology, animal physiology, metabolomics and bioinformatics to address our questions. We have maintained consistent NHMRC funding since 2015 and are always interested in passionate new lab members.

+61 2 9385 1621
  • Book Chapters | 2020
    Li C; Chalmers TJ; Wong ASA; Zhou M; Marinova MB; Bertoldo MJ; Wu LE, 2020, 'Chapter Six Hepatic regeneration in aging: Cell type plasticity and redundancies', in The Stem Cell Niche during Ageing, Elsevier, pp. 127 - 171, http://dx.doi.org/10.1016/bs.asn.2020.07.002
    Book Chapters | 2020
    Wu L, 2020, 'Hepatic regeneration in aging: Cell type plasticity and redundancies', in Nilsson S (ed.), The Stem Cell Niche during Ageing, Academic Press, http://dx.doi.org/10.1016/bs.asn.2020.07.002
    Book Chapters | 2016
    Massudi H; Wu LE; Sinclair DA, 2016, 'Sirtuin Activation by Small Molecules', in Houtkooper RH (ed.), SIRTUINS, edn. Proteins and Cell Regulation, SPRINGER, pp. 243 - 266, http://dx.doi.org/10.1007/978-94-024-0962-8_12
  • Journal articles | 2022
    Aflatounian A; Paris VR; Richani D; Edwards MC; Cochran BJ; Ledger WL; Gilchrist RB; Bertoldo MJ; Wu LE; Walters KA, 2022, 'Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation', Molecular Metabolism, vol. 65, pp. 101583, http://dx.doi.org/10.1016/j.molmet.2022.101583
    Journal articles | 2022
    Campbell JM; Mahbub SB; Bertoldo MJ; Habibalahi A; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2022, 'Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes', Biogerontology, vol. 23, pp. 237 - 249, http://dx.doi.org/10.1007/s10522-022-09957-y
    Journal articles | 2022
    Habibalahi A; Campbell JM; Bertoldo MJ; Mahbub SB; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2022, 'Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice', Biomedicines, vol. 10, pp. 1544 - 1544, http://dx.doi.org/10.3390/biomedicines10071544
    Journal articles | 2021
    Bertoldo MJ; Paris VR; Gook DA; Edwards MC; Wu K; Liang CJJ; Marinova MB; Wu LE; Walters KA; Gilchrist RB, 2021, 'Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue', Reproduction, vol. 161, pp. 215 - 226, http://dx.doi.org/10.1530/REP-20-0539
    Journal articles | 2021
    Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453
    Journal articles | 2021
    Li C; Wu LE, 2021, 'Risks and rewards of targeting NAD+ homeostasis in the brain', Mechanisms of Ageing and Development, vol. 198, pp. 111545, http://dx.doi.org/10.1016/j.mad.2021.111545
    Journal articles | 2021
    Yu J; Laybutt DR; Kim LJ; Quek LE; Wu LE; Morris MJ; Youngson NA, 2021, 'Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide', American Journal of Physiology - Endocrinology and Metabolism, vol. 321, pp. E176 - E189, http://dx.doi.org/10.1152/AJPENDO.00446.2020
    Journal articles | 2020
    Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD+ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, vol. 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058
    Journal articles | 2020
    Bertoldo MJ; Smitz J; Wu LE; Lee HC; Woodruff TK; Gilchrist RB, 2020, 'Prospects of Rescuing Young Eggs for Oncofertility', Trends in Endocrinology and Metabolism, vol. 31, pp. 708 - 711, http://dx.doi.org/10.1016/j.tem.2020.07.004
    Journal articles | 2020
    Chalmers TJ; Wu LE, 2020, 'Transposable Elements Cross Kingdom Boundaries and Contribute to Inflammation and Ageing: Somatic Acquisition of Foreign Transposable Elements as a Catalyst of Genome Instability, Epigenetic Dysregulation, Inflammation, Senescence, and Ageing', BioEssays, vol. 42, http://dx.doi.org/10.1002/bies.201900197
    Journal articles | 2020
    Kim L-J; Chalmers TJ; Madawala R; Smith GC; Li C; Das A; Keung Poon EW; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, 2020, 'Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions', , http://dx.doi.org/10.1101/2020.09.10.289561
    Journal articles | 2020
    Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2020, 'Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (Cell Metabolism (2014) 19(3) (418–430), (S1550413114000655), (10.1016/j.cmet.2014.02.009))', Cell Metabolism, vol. 31, pp. 654, http://dx.doi.org/10.1016/j.cmet.2020.01.010
    Journal articles | 2020
    Journal articles | 2019
    Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, vol. 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026
    Journal articles | 2019
    Wu LE; Sinclair DA, 2019, 'The elusive NMN transporter is found', Nature Metabolism, vol. 1, pp. 8 - 9, http://dx.doi.org/10.1038/s42255-018-0015-6
    Journal articles | 2018
    Bonkowski MS; Das A; Schultz M; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair D, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, vol. 2, pp. 388 - 388, http://dx.doi.org/10.1093/geroni/igy023.1446
    Journal articles | 2018
    Bonkowski MS; Das A; Schultz MB; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair DA, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, vol. 2, pp. 799 - 799, http://dx.doi.org/10.1093/geroni/igy023.2966
    Journal articles | 2018
    Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, vol. 14, http://dx.doi.org/10.1007/s11306-017-1310-z
    Journal articles | 2018
    Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, vol. 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008
    Journal articles | 2018
    Latorre-Muro P; Baeza J; Armstrong EA; Hurtado-Guerrero R; Corzana F; Wu LE; Sinclair DA; López-Buesa P; Carrodeguas JA; Denu JM, 2018, 'Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions', Molecular Cell, vol. 71, pp. 718 - 732.e9, http://dx.doi.org/10.1016/j.molcel.2018.07.031
    Journal articles | 2018
    Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', ESMO Open, vol. 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56
    Journal articles | 2017
    Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159
    Journal articles | 2017
    Das A; Sinclair D; Bonkowski M; Johnston I; Wu L, 2017, 'Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors', Journal of Science and Medicine in Sport, vol. 20, pp. S165 - S166, http://dx.doi.org/10.1016/j.jsams.2017.09.564
    Journal articles | 2017
    Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms14689
    Journal articles | 2016
    Awan Z; Tay ESE; Eyre NS; Wu LE; Beard MR; Boo I; Drummer HE; George J; Douglas MW, 2016, 'Calsyntenin-1 mediates hepatitis C virus replication', Journal of General Virology, vol. 97, pp. 1877 - 1887, http://dx.doi.org/10.1099/jgv.0.000511
    Journal articles | 2016
    Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M; Sinclair DA; John JCS, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep23229
    Journal articles | 2016
    Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, vol. 473, pp. 1247 - 1255, http://dx.doi.org/10.1042/BCJ20160121
    Journal articles | 2016
    Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481
    Journal articles | 2016
    Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie - International Edition, vol. 55, pp. 1742 - 1745, http://dx.doi.org/10.1002/anie.201509065
    Journal articles | 2016
    Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie, vol. 128, pp. 1774 - 1777, http://dx.doi.org/10.1002/ange.201509065
    Journal articles | 2016
    Wu LE; Sinclair DA, 2016, 'Restoring stem cells-all you need is NAD+', Cell Research, vol. 26, pp. 971 - 972, http://dx.doi.org/10.1038/cr.2016.80
    Journal articles | 2015
    Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0130058
    Journal articles | 2015
    Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair DA; Homer H, 2015, 'Erratum: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes (PLoS ONE (2015) 10:5 (e0126194) DOI:10.1371/journal.pone.0126194)', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126194
    Journal articles | 2015
    Wu LE; Fazakerley DJ; Cantley J, 2015, 'Circulating AFABP promotes insulin secretion', Obesity, vol. 23, pp. 1525, http://dx.doi.org/10.1002/oby.21175
    Journal articles | 2014
    Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, vol. 34, pp. 3607 - 3617, http://dx.doi.org/10.1128/MCB.00583-14
    Journal articles | 2014
    North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, vol. 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907
    Journal articles | 2014
    Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009
    Journal articles | 2014
    Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, vol. 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005
    Journal articles | 2014
    Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, vol. 63, pp. 2656 - 2667, http://dx.doi.org/10.2337/db13-1665
    Journal articles | 2014
    Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, vol. 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005
    Journal articles | 2014
    Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, vol. 33, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713
    Journal articles | 2014
    Wu LE; Solon S; McMahon AC; Ballard JWO; Ruohonen K; Cogger VC; Warren A; Pichaud N; Melvin RG; Gokarn R; Khalil M; Huang X; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'Disparate consequences of macronutrients on appetite, longevity and cardiometabolic health reconciled by nutritional geometry', Cell Metabolism
    Journal articles | 2013
    Poorten DVD; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; McLeod D; Bugianesi E; Komuta M; Roskams T; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?†', Hepatology, vol. 57, pp. 2180 - 2188, http://dx.doi.org/10.1002/hep.26072
    Journal articles | 2010
    Hocking SL; Wu LE; Guilhaus M; Chisholm DJ; James DE, 2010, 'Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells', Diabetes, vol. 59, pp. 3008 - 3016, http://dx.doi.org/10.2337/db10-0483
    Journal articles | 2010
    Wu LE; Carter EA; Rayner BS; McLeod AI; Marshall CP; Levina A; Aitken JB; Witting PK; Lai B; Cai Z; Vogt S; Lee YC; Tobin MJ; Harris HH; Lay PA, 2010, 'Silicon Nitride as a Versatile Growth Substrate for Microspectroscopic Imaging and Mapping of Individual Cells.', Molecular Biosystems, vol. 6, pp. 1316 - 1322, http://dx.doi.org/10.1039/c001499k
    Journal articles | 2010
    Wu LE; Hocking SL; James DE, 2010, 'Macrophage infiltration and cytokine release in adipose tissue: angiogenesis or inflammation?', Diabetology International, vol. 1, pp. 26 - 34, http://dx.doi.org/10.1007/s13340-010-0003-x
    Journal articles | 2009
    Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, vol. 10, pp. 40 - 47, http://dx.doi.org/10.1016/j.cmet.2009.06.001
    Journal articles | 2008
    Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, vol. 7, pp. 421 - 433, http://dx.doi.org/10.1016/j.cmet.2008.04.005
    Journal articles | 2007
    Vogt S; Lai B; Finney L; Palmer B; Wu LE; Harris H; Paunesku T; de Jonge M; Legnini D; Maser J; Glesne D; Lay P; Woloschak G, 2007, 'Imaging trace elements in cells with x-ray fluorescence microscopy', MICROSCOPY AND MICROANALYSIS, vol. 13, pp. 40 - 41, http://dx.doi.org/10.1017/S1431927607076283
  • Working Papers | 2019
    Bertoldo M; Listijono D; Ho W-HJ; Riepsamen A; Jin X; Selesniemi K; Goss D; Mahbub S; Campbell J; Habibalahi A; Loh W-GN; Youngson N; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu R; Mikolaizak S; Araki T; Le Couteur D; Turner N; Morris M; Walters K; Goldys E; O’Neill C; Gilchrist R; Sinclair D; Homer H; Wu L, 2019, NAD+repletion rescues female fertility during reproductive ageing, http://dx.doi.org10.1101/721985
  • Preprints | 2021
    Habibalahi A; Bertoldo MJ; Mahbub SB; Campbell JM; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2021, NMN treatment reverses unique deep radiomic signature morphology of oocytes from aged mice, http://dx.doi.org/10.21203/rs.3.rs-951364/v1
    Conference Papers | 2021
    Mahbub SB; Campbell J; Tan TCY; Habibalahi A; Bertoldo MJ; Goss DM; Walter K; Wu LE; Dunning KR; Goldys E, 2021, 'Label-free multispectral identification of native fluorophores to assess embryo and oocyte quality', in Leary JF; Tarnok A; Georgakoudi I (eds.), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, SPIE, presented at Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 06 March 2021 - 12 March 2021, http://dx.doi.org/10.1117/12.2579141
    Preprints | 2020
    Kim L-J; Chalmers T; Smith G; Li C; Das A; Poon WKE; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, 2020, Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome, http://dx.doi.org/10.21203/rs.3.rs-87047/v1
    Conference Abstracts | 2020
    Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752
    Patents | 2020
    Wu L; Sinclair D, 2020, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. United Stated Patent no. 10603334
    Conference Papers | 2019
    Riepsamen A; Listijono D; Kalani S; Cooke S; Ledger W; Wu L; Sinclair D, 2019, 'Sirtuins are required for forming fertilization-ready eggs', in BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, BJOG: An International Journal of Obstetrics & Gynaecology, Brisbane, Australia, pp. 40 - 40, presented at Royal College of Obstetricians and Gynaecologists World Congress, Brisbane, Australia, 10 April 2019, http://dx.doi.org/10.1111/1471-0528.13368
    Conference Abstracts | 2017
    Chowdhury MKH; Morris M; Turner N; Wu L; Shepherd P; Smith G, 2017, 'Niclosamide blocks glucagon phosphorylation of serine 552 on beta-catenin leading to decrease target genes expression and improve glucose metabolism via PKA signalling pathway', in FASEB JOURNAL, WILEY, IL, Chicago, Vol. 31, presented at Experimental Biology (EB) Annual Meeting, IL, Chicago, 22 April 2017 - 26 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405461402087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Homer H; Riepsamen A; Wu LE; Sinclair D, 2015, 'Sirt2-mediated BubR1 regulation promotes oocyte maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, PORTUGAL, Lisbon, pp. 11 - 11, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), PORTUGAL, Lisbon, 14 June 2015 - 17 June 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359740300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Wu LE; James DE; Cantley J, 2010, 'Secreted adipocyte fatty acid binding protein (FABP4) forms the molecular basis of the adipo-insular axis', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, pp. S58 - S58, presented at 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), SWEDEN, Stockholm, 20 September 2010 - 24 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000280689700124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2009
    Wu LE; Larance M; Ramm G; Raftery M; Guilhaus M; James DE, 2009, 'Proteomic Analysis of Adipokine Secretion in Insulin Resistance', in DIABETES, AMER DIABETES ASSOC, LA, New Orleans, pp. A333 - A334, presented at 69th Annual Meeting of the American-Diabetes-Association, LA, New Orleans, 05 June 2009 - 09 June 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266352602014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

"Media formulations to enhance embryo formation in assisted reproduction": NHMRC Development Grant (2021-2023)

“Translating new advances in oncofertility”: NHMRC Project Grant APP1139763, (2018-2021).

“Preserving ovarian function during chemotherapy and old age”: NHMRC Career Development Fellowship (RD Wright Biomedical Fellowship) APP1127821 (2017-2020)

“Nicotinamide adenine dinucleotide (NAD+) raising agents for improving oocyte quality”: NHMRC Development Grant APP1122484 (2017-2019)

“Female reproductive health preservation by nicotinamide adenine dinucleotide (NAD+) and Sirtuin2 (SIRT2)”: NHMRC Project Grant APP1103689 (2016-2018)

“New drugs to prevent premature ageing and side effects of chemotherapy”: NHMRC Development Grant APP1093643 (2015-2017)

“Calorie restriction mimetics for the treatment of hepatocellular carcinoma”: Early Career Fellowship, Cancer Institute NSW (2014-2016). 





The Conversation

Wu, LE (2017). The search to extend lifespan is gaining ground, but can we truly reverse the biology of ageing? Selected for The Conversation Yearbook, "50 Standout Articles from Australia's Top Thinkers"

Wu LE, Mikolaizak AS (2017). I've always wondered - does anyone my age have a chance of living for centuries? 

Collins C, Wu LE (2016). Research check - can eating aged cheese help you age well?


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My Teaching

BABS2011 - Current Trends in Biotechnology

BIOC3271 - Molecular Cell Biology II

PHAR2011 - Introductory Pharmacology and Toxicology

PHAR9101 - Introduction to the Therapeutics Industry