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Associate Professor Liz Caldon

Conjoint Associate Professor

Medicine & Health

School of Clinical Medicine

E-mail

l.caldon@garvan.org.au

Journal articles | 2024

Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia KM; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Chen W; Pidsley R; Qu W; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, 2024, 'The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer', Nature Structural and Molecular Biology, 31, pp. 498 - 512, http://dx.doi.org/10.1038/s41594-023-01181-7

Journal articles | 2024

De Lacavalerie PA; Lord SJ; Morgan MJ; Caldon CE; Kohonen-Corish MRJ, 2024, 'Molecular biomarkers for predicting complete response to preoperative chemoradiation in people with locally advanced rectal cancer', Cochrane Database of Systematic Reviews, 2024, http://dx.doi.org/10.1002/14651858.CD014718

Journal articles | 2024

Holliday H; Yang J; Dodson E; Nikolic I; Kamili A; Wheatley M; Deng N; Alexandrou S; Davis TP; Kavallaris M; Caldon CE; McCarroll J; De Preter K; Mestdagh P; Marshall GM; Simpson KJ; Fletcher J; Swarbrick A, 2024, 'Erratum: miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma (Molecular Therapy (2022) 30(3) (1119–1134), (S1525001622000041), (10.1016/j.ymthe.2022.01.004))', Molecular Therapy, 32, pp. 2031 - 2033, http://dx.doi.org/10.1016/j.ymthe.2024.05.008

Journal articles | 2024

Hosseinpour M; Xi X; Liu L; Malaver-Ortega L; Perlaza-Jimenez L; Joo JE; York HM; Beesley J; Caldon CE; Dugué PA; Dowty JG; Arumugam S; Southey MC; Rosenbluh J, 2024, 'SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-54824-8

Journal articles | 2023

Morra A; Mavaddat N; Muranen TA; Ahearn TU; Allen J; Andrulis IL; Auvinen P; Becher H; Behrens S; Blomqvist C; Bojesen SE; Bolla MK; Brauch H; Camp NJ; Carvalho S; Castelao JE; Cessna MH; Chang-Claude J; Chenevix-Trench G; Sahlberg KK; Børresen-Dale AL; Gram IT; Olsen KS; Engebråten O; Naume B; Geisler J; OSBREAC ; Grenaker Alnæs GI; Czene K; Decker B; Dennis J; Dörk T; Dorling L; Dunning AM; Ekici AB; Eriksson M; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gago-Dominguez M; García-Closas M; Geurts-Giele WRR; Giles GG; Guénel P; Gündert M; Hahnen E; Hall P; Hamann U; Harrington PA; He W; Heikkilä P; Hooning MJ; Hoppe R; Howell A; Humphreys K; Amor D; Andrews L; Antill Y; Balleine R; Beesley J; Bennett I; Bogwitz M; Botes L; Brennan M; Brown M; Buckley M; Burke J; Butow P; Caldon L; Campbell I; Cao M; Chakrabarti A; Chauhan D; Chauhan M; Christian A; Cohen P; Colley A; Crook A; Cui J; Courtney E; Cummings M; Dawson SJ; DeFazio A; Delatycki M; Dickson R; Dixon J; Edkins T; Edwards S; Farshid G; Fellows A; Fenton G; Field M; Flanagan J; Fong P; Forrest L; Fox S; French J; Friedlander M; Gaff C, 2023, 'The impact of coding germline variants on contralateral breast cancer risk and survival', American Journal of Human Genetics, 110, pp. 475 - 486, http://dx.doi.org/10.1016/j.ajhg.2023.02.003

Journal articles | 2023

Phan Z; Ford CE; Caldon CE, 2023, 'DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review', Pharmacological Research, 196, http://dx.doi.org/10.1016/j.phrs.2023.106927

Journal articles | 2023

Zhou FH; Downton T; Freelander A; Hurwitz J; Caldon CE; Lim E, 2023, 'CDK4/6 inhibitor resistance in estrogen receptor positive breast cancer, a 2023 perspective', Frontiers in Cell and Developmental Biology, 11, http://dx.doi.org/10.3389/fcell.2023.1148792

Journal articles | 2022

Aziz D; Lee C; Chin V; Fernandez KJ; Phan Z; Waring P; Caldon CE, 2022, 'High cyclin E1 protein, but not gene amplification, is prognostic for basal-like breast cancer', Journal of Pathology: Clinical Research, 8, pp. 355 - 370, http://dx.doi.org/10.1002/cjp2.269

Journal articles | 2022

Holliday H; Yang J; Dodson E; Nikolic I; Kamili A; Wheatley M; Deng N; Alexandrou S; Davis TP; Kavallaris M; Caldon CE; McCarroll J; De Preter K; Mestdagh P; Marshall GM; Simpson KJ; Fletcher J; Swarbrick A, 2022, 'miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma', Molecular Therapy, 30, pp. 1119 - 1134, http://dx.doi.org/10.1016/j.ymthe.2022.01.004

Journal articles | 2022

Jahan Z; Benthani FA; Currey N; Parker HW; Dahlstrom JE; Caldon CE; Kohonen-Corish MRJ, 2022, 'MCC Gene Silencing Is a CpG Island Methylator Phenotype-Associated Factor That Predisposes Colon Cancer Cells to Irinotecan and Olaparib', Cancers, 14, http://dx.doi.org/10.3390/cancers14122859

Journal articles | 2021

Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Phan Z; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell DD; Serra V; Waring P; Lim E; Caldon CE, 2021, 'Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition', npj Breast Cancer, 7, http://dx.doi.org/10.1038/s41523-021-00312-x

Journal articles | 2021

Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109722

Journal articles | 2021

Floerchinger A; Murphy KJ; Latham SL; Warren SC; McCulloch AT; Lee YK; Stoehr J; Mélénec P; Guaman CS; Metcalf XL; Lee V; Zaratzian A; Da Silva A; Tayao M; Rolo S; Phimmachanh M; Sultani G; McDonald L; Mason SM; Ferrari N; Ooms LM; Johnsson AKE; Spence HJ; Olson MF; Machesky LM; Sansom OJ; Morton JP; Mitchell CA; Samuel MS; Croucher DR; Welch HCE; Blyth K; Caldon CE; Herrmann D; Anderson KI; Timpson P; Nobis M, 2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109689

Journal articles | 2021

Hickey TE; Selth LA; Chia KM; Laven-Law G; Milioli HH; Roden D; Jindal S; Hui M; Finlay-Schultz J; Ebrahimie E; Birrell SN; Stelloo S; Iggo R; Alexandrou S; Caldon CE; Abdel-Fatah TM; Ellis IO; Zwart W; Palmieri C; Sartorius CA; Swarbrick A; Lim E; Carroll JS; Tilley WD, 2021, 'The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer', Nature Medicine, 27, pp. 310 - 320, http://dx.doi.org/10.1038/s41591-020-01168-7

Journal articles | 2021

Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363

Journal articles | 2020

Achinger-Kawecka J; Valdes-Mora F; Luu PL; Giles KA; Caldon CE; Qu W; Nair S; Soto S; Locke WJ; Yeo-Teh NS; Gould CM; Du Q; Smith GC; Ramos IR; Fernandez KF; Hoon DS; Gee JMW; Stirzaker C; Clark SJ; Valdes Mora F, 2020, 'Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer', Nature Communications, 11, pp. 320, http://dx.doi.org/10.1038/s41467-019-14098-x

Journal articles | 2020

Burgess A; Caldon CE, 2020, 'Editorial: Proceedings From ACCM19: Cell Cycle, DNA Damage Response and Telomeres', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00805

Journal articles | 2020

Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0

Journal articles | 2020

Du Q; Smith G; Luu PL; Ferguson J; Armstrong N; Caldon E; Campbell E; Nair S; Zotenko E; Gould C; Buckley M; Kaczorowski D; Barton K; Deveson I; Smith M; Powell J; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark S, 2020, 'DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity', , http://dx.doi.org/10.1101/2020.10.15.338855

Journal articles | 2020

Elizabeth Caldon C; Caldon L, 2020, 'Friends and foes: Our evolving understanding of the link between Fbxw7 and p53 in cancer', Neoplasia (United States), 22, pp. 659 - 660, http://dx.doi.org/10.1016/j.neo.2020.07.007

Journal articles | 2020

Kramer I; Hooning MJ; Mavaddat N; Hauptmann M; Keeman R; Steyerberg EW; Giardiello D; Antoniou AC; Pharoah PDP; Canisius S; Abu-Ful Z; Andrulis IL; Anton-Culver H; Aronson KJ; Augustinsson A; Becher H; Beckmann MW; Behrens S; Benitez J; Bermisheva M; Bogdanova NV; Bojesen SE; Bolla MK; Bonanni B; Brauch H; Bremer M; Brucker SY; Burwinkel B; Castelao JE; Chan TL; Chang-Claude J; Chanock SJ; Chenevix-Trench G; Choi JY; Clarke CL; Børresen-Dale AL; Sahlberg K; Ottestad L; Kåresen R; Schlichting E; Holmen MM; Sauer T; Haakensen V; Engebråten O; Naume B; Fosså A; Kiserud C; Reinertsen K; Helland Å; Riis M; Geisler J; Alnæs GG; Collée JM; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Devilee P; Dörk T; dos-Santos-Silva I; Dunning AM; Dwek M; Eccles DM; Evans DG; Fasching PA; Flyger H; Gago-Dominguez M; García-Closas M; García-Sáenz JA; Giles GG; Goldgar DE; González-Neira A; Haiman CA; Håkansson N; Hamann U; Hartman M; Heemskerk-Gerritsen BAM; Hollestelle A; Hopper JL; Hou MF; Howell A; Marsh D; Scott R; Baxter R; Yip D; Carpenter J; Davis A; Pathmanathan N; Simpson P; Graham JD; Sachchithananthan M; Amor D; Andrews L; Antill Y; Balleine R; Beesley J; Bennett I; Bogwitz M, 2020, 'Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk', American Journal of Human Genetics, 107, pp. 837 - 848, http://dx.doi.org/10.1016/j.ajhg.2020.09.001

Journal articles | 2020

Lee C; Fernandez KJ; Alexandrou S; Marcelo Sergio C; Deng N; Rogers S; Burgess A; Elizabeth Caldon C, 2020, 'Cyclin E2 promotes whole genome doubling in breast cancer', Cancers, 12, pp. 1 - 19, http://dx.doi.org/10.3390/cancers12082268

Journal articles | 2020

Milioli HH; Alexandrou S; Lim E; Caldon CE, 2020, 'Cyclin E1 and cyclin E2 in ER+ breast cancer: Prospects as biomarkers and therapeutic targets', Endocrine-Related Cancer, 27, pp. R93 - R112, http://dx.doi.org/10.1530/ERC-19-0501

Journal articles | 2020

Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', Breast Cancer Research, 22, pp. 87, http://dx.doi.org/10.1186/s13058-020-01318-2

Journal articles | 2020

Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer', , http://dx.doi.org/10.1101/2020.06.09.140921

Journal articles | 2020

Tadesse S; Anshabo AT; Portman N; Lim E; Tilley W; Caldon CE; Wang S, 2020, 'Targeting CDK2 in cancer: challenges and opportunities for therapy', Drug Discovery Today, 25, pp. 406 - 413, http://dx.doi.org/10.1016/j.drudis.2019.12.001

Journal articles | 2019

Alexandrou S; George SM; Ormandy CJ; Lim E; Oakes SR; Elizabeth Caldon C, 2019, 'The proliferative and apoptotic landscape of basal-like breast cancer', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20030667

Journal articles | 2019

Aziz D; Lee C; Chin V; Fernandez K; Etemadmoghadam D; Bowtell D; Waring PM; Caldon CE, 2019, 'Cyclin E1 is a shared biomarker of subsets of high grade serous ovarian cancer (HGSOC) and basal like breast cancer (BLBC)', Annals of Oncology, 30, pp. ix86 - ix86, http://dx.doi.org/10.1093/annonc/mdz426.029

Journal articles | 2019

Caldon CE; Burgess A, 2019, 'Label free, quantitative single-cell fate tracking of time-lapse movies', MethodsX, 6, pp. 2468 - 2475, http://dx.doi.org/10.1016/j.mex.2019.10.014

Journal articles | 2019

Chia KM; Milioli H; Portman N; Laven-Law G; Coulson R; Yong A; Segara D; Parker A; Caldon CE; Deng N; Swarbrick A; Tilley WD; Hickey TE; Lim E, 2019, 'Non-canonical AR activity facilitates endocrine resistance in breast cancer', Endocrine-Related Cancer, 26, pp. 251 - 264, http://dx.doi.org/10.1530/ERC-18-0333

Journal articles | 2019

Currey N; Jahan Z; Caldon CE; Tran PN; Benthani F; De Lacavalerie P; Roden DL; Gloss BS; Campos C; Bean EG; Bullman A; Reibe-Pal S; Dinger ME; Febbraio MA; Clarke SJ; Dahlstrom JE; Kohonen-Corish MRJ, 2019, 'Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer', Cellular and Molecular Gastroenterology and Hepatology, 7, pp. 819 - 839, http://dx.doi.org/10.1016/j.jcmgh.2019.01.009

Journal articles | 2019

Du Q; Bert SA; Armstrong NJ; Caldon CE; Song JZ; Nair SS; Gould CM; Luu PL; Peters T; Khoury A; Qu W; Zotenko E; Stirzaker C; Clark SJ, 2019, 'Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-08302-1

Journal articles | 2019

Figlioli G; Bogliolo M; Catucci I; Caleca L; Lasheras SV; Pujol R; Kiiski JI; Muranen TA; Barnes DR; Dennis J; Michailidou K; Bolla MK; Leslie G; Aalfs CM; Balleine R; Baxter R; Braye S; Carpenter J; Dahlstrom J; Forbes J; Lee CS; Marsh D; Morey A; Pathmanathan N; Scott R; Simpson P; Spigelman A; Wilcken N; Yip D; Zeps N; Adank MA; Adlard J; Agata S; Cadoo K; Agnarsson BA; Ahearn T; Aittomäki K; Ambrosone CB; Andrews L; Anton-Culver H; Antonenkova NN; Arndt V; Arnold N; Aronson KJ; Arun BK; Asseryanis E; Auber B; Auvinen P; Azzollini J; Balmaña J; Barkardottir RB; Barrowdale D; Barwell J; Beane Freeman LE; Beauparlant CJ; Beckmann MW; Behrens S; Benitez J; Berger R; Bermisheva M; Blanco AM; Blomqvist C; Bogdanova NV; Bojesen A; Bojesen SE; Bonanni B; Borg A; Brady AF; Brauch H; Brenner H; Brüning T; Burwinkel B; Buys SS; Caldés T; Caliebe A; Caligo MA; Campa D; Campbell IG; Canzian F; Castelao JE; Chang-Claude J; Chanock SJ; Claes KBM; Clarke CL; Collavoli A; Conner TA; Cox DG; Cybulski C; Czene K; Daly MB; de la Hoya M; Devilee P; Diez O; Ding YC; Dite GS; Ditsch N; Domchek SM; Dorfling CM; dos-Santos-Silva I; Durda K, 2019, 'The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer', npj Breast Cancer, 5, http://dx.doi.org/10.1038/s41523-019-0127-5

Journal articles | 2019

Lee CS; Rogers S; Fernandez K; Alexandrou S; Deng N; Sergio CM; Kulkarni A; Gugasyan L; Musgrove EA; Deans AJ; Burgess A; Caldon CE, 2019, 'Mechanisms underlying uncontrolled genome doubling in breast cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p008

Journal articles | 2019

Li A; Geyer FC; Blecua P; Lee JY; Selenica P; Brown DN; Pareja F; Lee SSK; Kumar R; Rivera B; Bi R; Piscuoglio S; Wen HY; Lozada JR; Gularte-Mérida R; Cavallone L; Aghmesheh M; Amor D; Andrews L; Antill Y; Balleine R; Beesley J; Blackburn A; Bogwitz M; Brown M; Burgess M; Burke J; Butow P; Caldon L; Campbell I; Christian A; Clarke C; Cohen P; Crook A; Cui J; Cummings M; Dawson SJ; De Fazio A; Delatycki M; Dobrovic A; Dudding T; Duijf P; Edkins E; Edwards S; Farshid G; Fellows A; Field M; Flanagan J; Fong P; Forbes J; Forrest L; Fox S; French J; Friedlander M; Ortega DG; Gattas M; Giles G; Gill G; Gleeson M; Greening S; Haan E; Harris M; Hayward N; Hickie I; Hopper J; Hunt C; James P; Jenkins M; Kefford R; Kentwell M; Kirk J; Kollias J; Lakhani S; Lindeman G; Lipton L; Lobb L; Lok S; Macrea F; Mann G; Marsh D; McLachlan SA; Meiser B; Milne R; Nightingale S; O’Connell S; Pachter N; Patterson B; Phillips K; Saleh M; Salisbury E; Saunders C; Saunus J; Scott C; Scott R; Sexton A; Shelling A; Simpson P; Spigelman A; Spurdle M; Stone J, 2019, 'Homologous recombination DNA repair defects in PALB2-associated breast cancers', npj Breast Cancer, 5, http://dx.doi.org/10.1038/s41523-019-0115-9

Journal articles | 2019

Portman N; Alexandrou S; Carson E; Wang S; Lim E; Caldon CE, 2019, 'Overcoming CDK4/6 inhibitor resistance in ER-positive breast cancer', Endocrine-Related Cancer, 26, pp. R15 - R30, http://dx.doi.org/10.1530/ERC-18-0317

Journal articles | 2019

Tadesse S; Caldon EC; Tilley W; Wang S, 2019, 'Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update', Journal of Medicinal Chemistry, 62, pp. 4233 - 4251, http://dx.doi.org/10.1021/acs.jmedchem.8b01469

Journal articles | 2018

Aziz D; Etemadmoghadam D; Caldon CE; Au-Yeung G; Deng N; Hutchinson R; Bowtell D; Waring P, 2018, '19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes', Gynecologic Oncology, 151, pp. 327 - 336, http://dx.doi.org/10.1016/j.ygyno.2018.08.039

Journal articles | 2018

Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P; del Monte Nieto G; Gallego-Ortega D, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Journal articles | 2018

Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z

Journal articles | 2017

Law AMK; Yin JXM; Castillo L; Young AIJ; Piggin C; Rogers S; Caldon CE; Burgess A; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2017, 'Andy's Algorithms: New automated digital image analysis pipelines for FIJI', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-15885-6

Journal articles | 2016

Caldon CE, 2016, 'Cdk2 regulates metastasis suppressor BRMS1', Cell Cycle, 15, pp. 779 - 780, http://dx.doi.org/10.1080/15384101.2015.1136521

Journal articles | 2016

Rogers S; Fey D; McCloy RA; Parker BL; Mitchell NJ; Payne RJ; Daly RJ; James DE; Caldon CE; Watkins DN; Croucher DR; Burgess A, 2016, 'PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells', Journal of Cell Science, 129, pp. 1340 - 1354, http://dx.doi.org/10.1242/jcs.179754

Journal articles | 2015

Loh SF; Cooper C; Selinger CI; Barnes EH; Chan C; Carmalt H; West R; Gluch L; Beith JM; Caldon CE; O'Toole S, 2015, 'Cell cycle marker expression in benign and malignant intraductal papillary lesions of the breast', Journal of Clinical Pathology, 68, pp. 187 - 191, http://dx.doi.org/10.1136/jclinpath-2014-202331

Journal articles | 2015

Rogers S; Gloss BS; Lee CS; Sergio CM; Dinger ME; Musgrove EA; Burgess A; Caldon CE, 2015, 'Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells', Cell Division, 10, pp. 1, http://dx.doi.org/10.1186/s13008-015-0007-9

Journal articles | 2015

Susanto JM; Colvin EK; Pinese M; Chang DK; Pajic M; Mawson A; Caldon CE; Musgrove EA; Henshall SM; Sutherland RL; Biankin AV; Scarlett CJ, 2015, 'The epigenetic agents suberoylanilide hydroxamic acid and 5-AZA-2′ deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo', International Journal of Oncology, 46, pp. 2223 - 2230, http://dx.doi.org/10.3892/ijo.2015.2894

Journal articles | 2014

Caldon CE, 2014, 'Estrogen signaling and the dna damage response in hormone dependent breast cancers', Frontiers in Oncology, 4 MAY, http://dx.doi.org/10.3389/fonc.2014.00106

Journal articles | 2014

McCloy RA; Rogers S; Caldon CE; Lorca T; Castro A; Burgess A, 2014, 'Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events', Cell Cycle, 13, pp. 1400 - 1412, http://dx.doi.org/10.4161/cc.28401

Journal articles | 2013

Caldon CE; Sergio CM; Burgess A; Deans AJ; Sutherland RL; Musgrove EA, 2013, 'Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1', Cell Cycle, 12, pp. 606 - 617, http://dx.doi.org/10.4161/cc.23512

Journal articles | 2013

Ortiz-padilla C; Gallego-ortega D; Browne B; Hochgrafe F; Caldon CE; Lyons R; Croucher DR; Rickwood D; Ormandy CJ; Brummer T; Daly RJ, 2013, 'Functional characterization of cancer-associated Gab1 mutations', Oncogene, 32, pp. 2696 - 2702, http://dx.doi.org/10.1038/onc.2012.271

Journal articles | 2013

Stone A; Cowley MJ; Valdes-Mora F; McCloy RA; Sergio CM; Gallego-Ortega D; Caldon CE; Ormandy CJ; Biankin AV; Gee JMW; Nicholson RI; Print CG; Clark SJ; Musgrove EA, 2013, 'BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer', Molecular Cancer Therapeutics, 12, pp. 1874 - 1885, http://dx.doi.org/10.1158/1535-7163.MCT-13-0012

Journal articles | 2012

Caldon CE; Sergio CM; Kang J; Muthukaruppan A; Boersma MN; Stone A; Barraclough J; Lee CS; Black MA; Miller LD; Gee JM; Nicholson RI; Sutherland RL; Print CG; Musgrove EA, 2012, 'Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells', MOLECULAR CANCER THERAPEUTICS, 11, pp. 1488 - 1499, http://dx.doi.org/10.1158/1535-7163.MCT-11-0963

Journal articles | 2012

Caldon CE; Sergio CM; Kang JW; Muthukaruppan A; Boersma M; Stone A; Barraclough J; Lee CS; Black MJ; Miller LA; Gee JMW; Robert i nicholson RI; Sutherland RL; Print C; Musgrove EA, 2012, 'Cyclin E2 overexpression is associated with endocrine resistance but not insensivity to CDK2 inhibition in human breast cancer cells', Molecular Cancer Therapeutics, 11, pp. 1488 - 1499, http://dx.doi.org/10.1158/1535-7163.MCT-11-0963

Journal articles | 2012

Kalyuga M; Gallego-Ortega D; Lee H; Roden DL; Cowley MJ; Caldon CE; Stone A; Allerdice SL; Valdes-Mora F; Rosalind launchbury R; Statham A; Armstrong NJ; Alles MC; Adelaide young A; Egger A; Au W; Piggin CL; Evans C; Ledger A; Brummer T; Oakes SR; Kaplan W; Gee JMW; Robert i nicholson RI; Sutherland RL; Swarbrick A; Naylor MJ; Clark SJ; Carroll JS; Ormandy CJ, 2012, 'ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer', PLoS Biology, 10, pp. e1001461, http://dx.doi.org/10.1371/journal.pbio.1001461

Journal articles | 2011

Musgrove EA; Caldon CE; Barraclough J; Stone A; Sutherland RL, 2011, 'Cyclin D as a therapeutic target in cancer', Nature Reviews Cancer, 11, pp. 558 - 572, http://dx.doi.org/10.1038/nrc3090

Journal articles | 2009

Caldon CE; Sergio CM; Schutte J; Boersma M; Sutherland RL; Carroll J; Musgrove EA, 2009, 'Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc', Molecular and Cellular Biology, 29, pp. 4623 - 4639

Journal articles | 2008

Butt A; Caldon CE; Mcneil CM; Swarbrick A; Musgrove EA; Sutherland RL, 2008, 'Cell cycle machinery: Links with genesis and treatment of breast cancer', Advances in Experimental Medicine and Biology, 630, pp. 189 - 205

Journal articles | 2008

Caldon CE; Lee CS; Sutherland RL; Musgrove EA, 2008, 'Wilms` tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation', Oncogene, 27, pp. 126 - 138, http://dx.doi.org/10.1038/sj.onc.1210622

Journal articles | 2008

Caldon CE; Swarbrick A; Lee CS; Sutherland RL; Musgrove EA, 2008, 'The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini', Cancer research, 68, pp. 3026 - 3036, http://dx.doi.org/10.1158/0008-5472.CAN-07-3079

Journal articles | 2008

Musgrove EA; Sergio CM; Loi S; Inman CK; Anderson LR; Alles MC; Pinese M; Caldon CE; Schutte J; Gardiner-Garden M; Ormandy CJ; McArthur G; Butt A; Sutherland RL, 2008, 'Identification of functional networks of estrogen-and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer', PLoS One, 3, pp. 2987 - 2995

Journal articles | 2006

Brummer T; Schramek D; Hayes V; Bennett HL; Caldon CE; Musgrove EA; Daly RJ, 2006, 'Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein', The Journal of Biological Chemistry, 281, pp. 626 - 637

Journal articles | 2006

Caldon CE; Daly RJ; Sutherland RL; Musgrove EA, 2006, 'Cell cycle control in breast cancer cells', Journal of Cellular Biochemistry, 97, pp. 261 - 274

Journal articles | 2005

Swarbrick A; Akerfeldt M; Lee CS; Sergio CM; Caldon CE; Hunter LJ; Sutherland RL; Musgrove EA; Lee CS, 2005, 'Regulation of cyclin expression and cell cycle progression in breastepithelial cells by the helix-loop-helix protein Id1', Oncogene, 24, pp. 381 - 389

Journal articles | 2004

Kus BM; Caldon CE; Andorn-Broza R; Edwards AM, 2004, 'Functional Interaction of 13 Yeast SCF Complexes with a Set of Yeast E2 Enzymes In Vitro', Proteins: Structure, Function and Genetics, 54, pp. 455 - 467, http://dx.doi.org/10.1002/prot.10620

Journal articles | 2004

Nadkarni MA; Caldon CE; Chhour KL; Fisher IP; Martin FE; Jacques NA; Hunter N, 2004, 'Carious dentine provides a habitat for a complex array of novel Prevotella-like bacteria', Journal of Clinical Microbiology, 42, pp. 5238 - 5244, http://dx.doi.org/10.1128/JCM.42.11.5238-5244.2004

Journal articles | 2003

Paramaesvaran M; Caldon E; Najdi S; Gonzaga G; Hunter N; Nguyen K; McDonald J; Langley DB; Crossley MJ; Collyer CA; Esvaran M, 2003, 'Porphyrin-mediated Cell Surface Heme Capture from Hemoglobin by Porphyromonas gingivalis.', Journal of Bacteriology, 185, pp. 2528 - 2537, http://dx.doi.org/10.1128/JB.185.8.2528-2537.2003

Journal articles | 2001

March PE, 2001, 'Evolution of a molecular switch;universal bacterial GTPases regulate ribosome function', Molecular Microbiology, pp. 289 - 297
Working Papers | 2020

Du Q; Smith G; Luu PL; Ferguson J; Armstrong N; Caldon E; Campbell E; Nair S; Zotenko E; Gould C; Buckley M; Kaczorowski D; Barton K; Deveson I; Smith M; Powell J; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark S, 2020, DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity, http://dx.doi.org10.1101/2020.10.15.338855
Preprints | 2025

Caldon C; Alexandrou S; Lee C; Fernandez K; Wiharja C; Eshraghi L; Reeves J; Reed D; Portman N; Phan Z; Milioli H; Nikolic I; Cadell A; Croucher D; Simpson K; Lim E; Hickey T; Millar E; Alves C; Ditzel H, 2025, JNK pathway suppression drives resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer, http://dx.doi.org/10.21203/rs.3.rs-5920749/v1

Preprints | 2025

Phan Z; Fernandez KJ; Caldon CE, 2025, Unmatched cell line collections are not optimal for identification of PARP inhibitor response and drug synergies, http://dx.doi.org/10.1101/2025.04.28.650908

Preprints | 2024

Hosseinpour M; Malaver-Ortega L; Perlaza-Jimenez L; Joo JE; Liu L; Caldon EC; Dugué P-A; Dowty JG; Southey MC; Rosenbluh J, 2024, SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers, http://dx.doi.org/10.1101/2024.01.16.575955

Preprints | 2023

Phan Z; Ford C; Caldon E, 2023, DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: a meta-analysis and systematic review, http://dx.doi.org/10.1101/2023.05.24.23290442

Conference Abstracts | 2022

Freelander A; Laven-Law G; Eshraghi L; Geetha N; Somerville P; Pickering M; Alexandrou S; Caldon CE; Tilley WD; Hickey TE; Lim E, 2022, 'Selective Androgen Receptor Modulators in combination with CDK4/6 inhibitors demonstrate anti-cancer activity in preclinical treatment resistant ER plus AR plus breast cancer models', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 83, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 06 December 2022 - 10 December 2022, http://dx.doi.org/10.1158/1538-7445.SABCS22-P4-08-16

Conference Abstracts | 2021

Freelander A; Laven-Law G; Eshraghi L; Chia KM; Pickering M; Yong A; Wilkinson A; Alexandrou S; Caldon CE; Hickey TE; Tilley WD; Lim E, 2021, 'Combination CDK4/6 inhibition and AR agonism suppresses the growth of CDK4/6 inhibitor resistant breast cancers', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 82, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 07 December 2021 - 10 December 2021, http://dx.doi.org/10.1158/1538-7445.SABCS21-PD2-02

Preprints | 2020

Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell D; Investigators K; Serra V; Waring P; Lim E; Caldon CE, 2020, Cyclin E1 protein is stabilized inBRCA1mutated breast cancers leading to synergy between CDK2 and PARP inhibitors, http://dx.doi.org/10.1101/2020.01.29.911883

Conference Abstracts | 2020

Hickey T; Selth L; Chia KM; Milioli HH; Laven-Law G; Roden D; Jindal S; Hui M; Ebrahimie E; Birrel SN; Stello S; Iggo R; Alexandrou S; Caldon L; Finlay-Shultz J; Abdel-Fatah TM; Ellis IO; Zwart W; Palmieri C; Sartorious CA; Swarbrick A; Lim E; Carrol JS; Tilley WD, 2020, 'The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer', in Journal of the Endocrine Society, Oxford University Press (OUP), Vol. 4, pp. or05 - or06, presented at Endocrine Society Annual Meeting, http://dx.doi.org/10.1210/jendso/bvaa046.982

Preprints | 2020

Tilley W; Hickey T; Selth L; Chia KM; Milioli H; Laven-Law G; Roden D; Jindal S; Hui M; Finlay-Schultz J; Ebrahimie E; Birrell S; Stelloo S; Iggo R; Alexandrou S; Caldon C; Abdel-Fatah T; Ellis I; Zwart W; Palmieri C; Sartorius C; Swarbrick A; Lim E; Carroll J, 2020, The Androgen Receptor is a Tumour Suppressor in Estrogen Receptor Positive Breast Cancer, http://dx.doi.org/10.21203/rs.3.rs-62718/v1

Conference Abstracts | 2019

Alexandrou S; Milioli HH; Portman N; Lee C; Fernandez K; Blake D; Lim E; Caldon L, 2019, 'S phase dysregulation occurs following resistance to CDK4/6 inhibition ER+ breast cancer', in Oncolabs, Bioscientifica, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P001

Conference Abstracts | 2019

Aziz D; Lee C; Chin V; Fernandez K; Etemadmoghadam D; Bowtell D; Waring PM; Caldon CE, 2019, 'Cyclin E1 is a shared biomarker of subsets of high grade serous ovarian cancer (HGSOC) and basal like breast cancer (BLBC)', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SINGAPORE, Singapore, Vol. 30, presented at European-Society-for-Medical-Oncology (ESMO) Asia Congress, SINGAPORE, Singapore, 22 November 2019 - 24 November 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000503487700245&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2019

Chia KM; Milioli HH; Portman N; Laven-Law G; Coulson R; Young A; Segara D; Parker A; Caldon L; Deng N; Swarbrick A; Tilley W; Hickey T; Lim E, 2019, 'Targeting AR in endocrine-resistant breast cancer', in Oncolabs, Bioscientifica, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P012

Conference Abstracts | 2019

Lim E; Hickey TA; Selth LA; Chia KM; Milioli HH; Roden D; Laven-Law G; Jindal S; Hui M; Ebrahimie E; Birrell SN; Stelloo S; Caldon CE; Finlay-Schultz J; Abdel-Fatah TM; Ellis IO; Zwart W; Palmieri C; Sartorius CA; Swarbrick A; Carroll JS; Tilley WD, 2019, 'Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), TX, San Antonio, Vol. 80, pp. gs2-03-gs2-03, presented at 42nd Annual San Antonio Breast Cancer Symposium, TX, San Antonio, 09 December 2019 - 14 December 2019, http://dx.doi.org/10.1158/1538-7445.sabcs19-gs2-03

Conference Presentations | 2019

Portman N; Milioli HH; Alexandrou S; Coulson R; Young A; Chia KM; Haup S; Haup Y; Caldon L; Lim E, 2019, 'The MDM2 inhibitor NVP-CGM097 synergises with fulvestrant and inhibits Estrogen Receptor positive breast cancer', presented at Hormone-Dependent Cancers (GRS), Newry, USA

Conference Abstracts | 2019

Portman N; Milioli HH; Young A; Coulson R; Alexandrou S; Lam N; Haup S; Haup Y; Caldon L; Deng N; Lim E, 2019, 'Activation of p53 in combination with endocrine and CDK targeted therapies in ER+ breast cancer', in Oncolabs, Bioscientifica, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P043

Preprints | 2018

Du Q; Bert SA; Armstrong NJ; Caldon CE; Song JZ; Nair SS; Gould CM; Luu PL; Khoury A; Qu W; Zotenko E; Stirzaker C; Clark SJ, 2018, Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements, http://dx.doi.org/10.1101/251280

Conference Abstracts | 2018

Whittle JR; Vaillant F; Policheni AN; Liu K; Pal B; Giner G; Fernandez K; Gray DH; Caldon CE; Smyth GK; Visvader JE; Lindeman GJ, 2018, 'Synergistic targeting of CDK4/6 and BCL-2 pathways in estrogen receptor positive breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 79, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 04 December 2018 - 08 December 2018, http://dx.doi.org/10.1158/1538-7445.SABCS18-PD7-07

Conference Abstracts | 2017

Lim E; Portman N; Alexandrou S; Haupt S; Haupt Y; Caldon E, 2017, 'Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 78, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 05 December 2017 - 09 December 2017

Conference Papers | 2009

O Toole SJ; Swarbrick A; Millar E; McLeod D; Mcneil CM; Qiu MR; Lopez-Knowles E; Caldon E; Oakes SR; Ormandy CJ; Morey AL; Musgrove EA; Henshall SM; Sutherland RL, 2009, 'Aberrent hedgehog signaling is an early event in breast cancer development', in Cancer research, American Association Cancer Research, Philadelphia, PA, pp. 70S - 70S

Conference Papers | 2003

Kus B; Caldon C; Edwards A, 2003, 'Proteome-wide biochemical screen to identify ubiquitination targets of yeast ubiquitin ligase enzymes', in YEAST, JOHN WILEY & SONS LTD, SWEDEN, GOTHENBURG, pp. S151 - S151, presented at 21st International Conference on Yeast Genetics and Molecular Biology, SWEDEN, GOTHENBURG, 07 July 2003 - 12 July 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184161800341&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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3 PhD students
1 Honours student

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Associate Professor Liz Caldon

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