Dr Lok Bahadur Shrestha

Dr Lok Bahadur Shrestha

Casual Academic

MBBS, MD (Microbiology & Infectious Diseases)

Medicine & Health
School of Biomedical Sciences

Dr. Lok completed his Bachelor of Medicine and Bachelor of Surgery (MBBS) in 2010 and Doctor of Medicine (MD) in Microbiology & Infectious Diseases in 2015. After completing MD, he worked as an Assistant Professor at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. He was primarily involved in teaching microbiology to medical and dental students, supervising diagnostic microbiology laboratory, and research activities. Initially, his research was focused on bacterial infections and antimicrobial resistance. He has worked as a microbiologist in an expert team during Dengue outbreak in 2019 and COVID-19 surveillance in 2020.

His research interests are antimicrobial resistance, virology, and immunology. His current research focuses on broadly neutralizing antibodies against the emerging variants of SARS-COV-2 and breadth of memory B cell response against SARS-CoV-2 variants.

  • Journal articles | 2024
    Mainali N; Shrestha AB; Shrestha S; Chapagain S; Khanal B; Shrestha LB; Shrestha S; Jaiswal V, 2024, 'mRNA vaccines as a revolutionary approach to combat cancer', Postgraduate Medical Journal, 100, pp. 279 - 282, http://dx.doi.org/10.1093/postmj/qgad138
    Journal articles | 2024
    Walker SJ; Shrestha LB; Lloyd AR; Dawson O; Sheehan Y; Sheehan J; Maduka NBC; Cabezas J; Akiyama MJ; Kronfli N, 2024, 'Barriers and advocacy needs for hepatitis C services in prisons: Informing the prisons hepatitis C advocacy toolkit', International Journal of Drug Policy, 126, http://dx.doi.org/10.1016/j.drugpo.2024.104386
    Journal articles | 2023
    Basnet A; Chand AB; Pokhrel N; Acharya S; Gurung P; Khanal LK; Shrestha K; Shrestha LB; Raghubanshi BR, 2023, 'Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients', Journal of Nepal Health Research Council, 20, pp. 664 - 671, http://dx.doi.org/10.33314/jnhrc.v20i3.4047
    Journal articles | 2023
    Basnet A; Tamang B; Shrestha MR; Shrestha LB; Rai JR; Maharjan R; Dahal S; Shrestha P; Rai SK, 2023, 'Assessment of four in vitro phenotypic biofilm detection methods in relation to antimicrobial resistance in aerobic clinical bacterial isolates', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0294646
    Journal articles | 2023
    Foster CSP; Bull RA; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker GJ; Shrestha LB; Van Hal SJ; Kim KW; Rawlinson WD, 2023, 'Persistence of a Frameshifting Deletion in SARS-CoV-2 ORF7a for the Duration of a Major Outbreak', Viruses, 15, http://dx.doi.org/10.3390/v15020522
    Journal articles | 2023
    Speck P; MacKenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peter J; Kriiger-Loteri R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse"', mSphere, 8, http://dx.doi.org/10.1128/msphere.00165-23
    Journal articles | 2023
    Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”', Journal of Virology, 97, http://dx.doi.org/10.1128/jvi.00451-23
    Journal articles | 2023
    Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”', mBio, 14, http://dx.doi.org/10.1128/mbio.00815-23
    Journal articles | 2022
    Balachandran H; Phetsouphanh C; Agapiou D; Adhikari A; Rodrigo C; Hammoud M; Shrestha LB; Keoshkerian E; Gupta M; Turville S; Christ D; King C; Sasson SC; Bartlett A; Grubor-Bauk B; Rawlinson W; Aggarwal A; Stella AO; Klemm V; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Ahlenstiel G; Dwyer DE; Sorrell TC; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, 2022, 'Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses', Cell Reports, 38, pp. 110345, http://dx.doi.org/10.1016/j.celrep.2022.110345
    Journal articles | 2022
    Basnet A; Chand AB; Pokhrel N; Gurung P; Rai JR; Bajracharya S; Acharya S; Shrestha LB, 2022, 'Status of Intestinal Parasitic Infections in a Tertiary Care Center', Journal of Nepal Health Research Council, 20, pp. 505 - 509, http://dx.doi.org/10.33314/jnhrc.v20i02.4049
    Journal articles | 2022
    Basnet A; Chand AB; Shrestha LB; Pokhrel N; Karki L; Shrestha SKD; Tamang B; Shrestha MR; Dulal M; Rai JR, 2022, 'Co-infection of Uropathogenic Escherichia coli among COVID-19 Patients Admitted to a Tertiary Care Centre: A Descriptive Cross-sectional Study', Journal of the Nepal Medical Association, 60, pp. 294 - 298, http://dx.doi.org/10.31729/jnma.7376
    Journal articles | 2022
    Chand AB; Basnet A; Shrestha LB; Sen B; Priyadarshinee A; Amatya I; Rajbanshi BR, 2022, 'Significance of Hematological Biomarkers in Association to Syphilitic Patients', Journal of Nepal Health Research Council, 20, pp. 426 - 430, http://dx.doi.org/10.33314/jnhrc.v20i02.4074
    Journal articles | 2022
    Chand AB; Singh S; Bhatt LR; Sen B; Joshi YP; Joshi P; Shrestha LB; Shrestha SKD; Basnet A, 2022, 'Vitamin D Deficiency among Patients Visiting Outpatient Departments in a Tertiary Care Centre: A Descriptive Cross-sectional Study', Journal of the Nepal Medical Association, 60, pp. 356 - 359, http://dx.doi.org/10.31729/jnma.7299
    Journal articles | 2022
    Pokharel K; Dawadi BR; Aryal B; Shrestha LB, 2022, 'PROFILE OF BREAKTHROUGH INFECTION OF COVID-19 IN A TERTIARY CARE HOSPITAL: A DESCRIPTIVE CROSS-SECTIONAL STUDY', Journal of Chitwan Medical College, 12, pp. 62 - 64, http://dx.doi.org/10.54530/jcmc.591
    Journal articles | 2022
    Pokharel K; Dawadi BR; Shrestha LB, 2022, 'Role of Biofilm in Bacterial Infection and Antimicrobial Resistanc', Journal of the Nepal Medical Association, 60, pp. 836 - 840, http://dx.doi.org/10.31729/jnma.7580
    Journal articles | 2022
    Shrestha DB; Budhathoki P; Gurung B; Subedi S; Aryal S; Basukala A; Aryal B; Adhikari A; Poudel A; Yadav GK; Khoury M; Rayamajhee B; Shrestha LB, 2022, 'Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis', Parasites and Vectors, 15, http://dx.doi.org/10.1186/s13071-022-05409-1
    Journal articles | 2022
    Shrestha LB; Foster C; Rawlinson W; Tedla N; Bull RA, 2022, 'Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission', Reviews in Medical Virology, http://dx.doi.org/10.1002/rmv.2381
    Journal articles | 2022
    Shrestha LB; Yadav GK; Pradhan S; Sharma A; Pandit T; Chhetry R; Khanal B, 2022, 'Co-infection of Hepatitis B and Hepatitis C among HIV-infected patients: A cross-sectional study from tertiary care hospital of eastern Nepal', PLOS ONE, 17, http://dx.doi.org/10.1371/journal.pone.0264791
    Journal articles | 2021
    Baral R; Shrestha LB; Ortuno-Gutierrez N; Pyakure P; Rai B; Rimal SP; Singh S; Sharma SK; Khanal B; Selvaraj K; Kumar AM, 2021, 'Low yield but high levels of multidrug resistance in urinary tract infections in a tertiary hospital, Nepal', PUBLIC HEALTH ACTION, 11, pp. 70 - 76, http://dx.doi.org/10.5588/pha.21.0044
    Journal articles | 2021
    Shrestha DB; Budhathoki P; Sedhai YR; Shrestha LB; Awal S; Upadhaya Regmi B; Yadav J; Baniya R; Thapaliya S; Dangal G, 2021, 'Prevalence of Hepatitis B and C among HIV Infected Patients in Nepal over 1990-2020.', Kathmandu Univ Med J (KUMJ), 19, pp. 132 - 139, https://www.ncbi.nlm.nih.gov/pubmed/34812172
    Journal articles | 2021
    Shrestha LB; Syangtan G; Basnet A; Acharya KP; Chand AB; Pokhrel K, 2021, 'Methicillin-resistant staphylococcus aureus in nepal', Journal of the Nepal Medical Association, 59, pp. 518 - 522, http://dx.doi.org/10.31729/JNMA.6251
    Journal articles | 2021
    Shrestha LB; Tedla N; Bull RA, 2021, 'Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 Variants', Frontiers in Immunology, 12, http://dx.doi.org/10.3389/fimmu.2021.752003
    Journal articles | 2021
    Shrestha M; Baral R; Shrestha LB, 2021, 'Metallo-β lactamase producing non-fermentative gram-negative bacilli from various clinical isolates in a tertiary care hospital: A descriptive cross-sectional study', Journal of the Nepal Medical Association, 59, pp. 875 - 880, http://dx.doi.org/10.31729/jnma.6408
    Journal articles | 2021
    Syangtan G; Bista S; Dawadi P; Rayamajhee B; Shrestha LB; Tuladhar R; Joshi DR, 2021, 'Asymptomatic SARS-CoV-2 Carriers: A Systematic Review and Meta-Analysis', Frontiers in Public Health, 8, http://dx.doi.org/10.3389/fpubh.2020.587374
    Journal articles | 2020
    Shrestha LB; Bhattarai NR; Rai K; Khanal B, 2020, 'Antibiotic resistance and mecA gene characterization of coauglase-negative Staphylococci isolated form clinical samples in Nepal.', Infection and drug resistance, 13, pp. 3163 - 69
    Journal articles | 2020
    Shrestha LB; Pokharel K, 2020, 'Standard operating procedure for specimen collection, packaging and transport for diagnosis of SARS-CoV-2', Journal of the Nepal Medical Association, 58, http://dx.doi.org/10.31729/jnma.5260
    Journal articles | 2020
    Shrestha LB, 2020, 'Multi-drug resistant and extended-spectrum lactamase producing bacteria in pediatric urinary tract infection', INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 101, pp. 27 - 27, http://dx.doi.org/10.1016/j.ijid.2020.09.106
    Journal articles | 2019
    Dumaru R; Baral R; Shrestha LBLB, 2019, 'Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan', BMC Research Notes, 12, http://dx.doi.org/10.1186/s13104-019-4084-8
    Journal articles | 2019
    Shah C; Baral R; Bartaula B; Shrestha LB, 2019, 'Virulence factors of uropathogenic Escherichia coli (UPEC) and correlation with antimicrobial resistance.', BMC microbiology, 19, pp. 204 - 204, http://dx.doi.org/10.1186/s12866-019-1587-3
    Journal articles | 2019
    Shrestha LB; Baral R; Khanal B, 2019, 'Comparative study of antimicrobial resistance and biofilm formation among Gram-positive uropathogens isolated from community-acquired urinary tract infections and catheter-associated urinary tract infections.', Infection and drug resistance, 12, pp. 957 - 963, http://dx.doi.org/10.2147/IDR.S200988
    Journal articles | 2019
    Shrestha LB; Baral R; Poudel P; Khanal B, 2019, 'Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal.', BMC pediatrics, 19, pp. 36 - 36, http://dx.doi.org/10.1186/s12887-019-1410-1
    Journal articles | 2019
    Shrestha LB; Bhattarai NR; Khanal B, 2019, 'Bacteriological Profile and Antimicrobial Susceptibility Pattern among Isolates Obtained From Body Fluids.', Journal of Nepal Health Research Council, 17, pp. 173 - 177, http://dx.doi.org/10.33314/jnhrc.v0i0.1656
    Journal articles | 2018
    Shrestha L; Bhattarai NR; Khanal B, 2018, 'Comparative evaluation of methods for the detection of biofilm formation in coagulase-negative staphylococci and correlation with antibiogram', Infection and Drug Resistance, Volume 11, pp. 607 - 613, http://dx.doi.org/10.2147/IDR.S159764
    Journal articles | 2017
    Shrestha LB; Bhattarai NR; Khanal B, 2017, 'Antibiotic resistance and biofilm formation among coagulase-negative staphylococci isolated from clinical samples at a tertiary care hospital of eastern Nepal', Antimicrobial Resistance and Infection Control, 6, pp. 1 - 7, http://dx.doi.org/10.1186/s13756-017-0251-7
  • Preprints | 2022
    Foster CSP; Bull R; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker G; Shrestha LB; van Hal S; Kim KW; Rawlinson W, 2022, Persistence of a SARS-CoV-2 variant with a frameshifting deletion for the duration of a major outbreak, , http://dx.doi.org/10.1101/2022.09.06.22279658
    Preprints | 2020
    Syangtan G; Bista S; Dawadi P; Rayamajhee B; Shrestha LB; Tuladhar R; Joshi DR, 2020, Asymptomatic people with SARS-CoV-2 as unseen carriers of COVID-19: A systematic review and meta-analysis, , http://dx.doi.org/10.21203/rs.3.rs-39512/v1
    Conference Papers | 2016
    Khanal B; Yadav A; Pandit T; Shrestha LB; Raj BN, 2016, 'Multidrug resistant blood culture isolates: An experience from a tertiary care hospital in Eastern Nepal', in INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, ELSEVIER SCI LTD, pp. 97 - 97, http://dx.doi.org/10.1016/j.ijid.2016.02.256
    Preprints |
    Balachandran H; Phetsouphanh C; Agapiou D; Adhikari A; Rodrigo C; Hammoud M; Shrestha LB; Keoshkerian E; Gupta M; Turville S; Christ D; King C; Sasson S; Bartlett A; Grubor-Bauk B; Rawlinson W; Aggarwal A; Stella AO; Klemm V; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Ahlenstiel G; Dwyer D; Sorrell TC; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses, , http://dx.doi.org/10.2139/ssrn.3920641

 

  • Bill & Melinda Gates Foundation Young Investigator Award (2019).
  • Citation Classic Award for the review article "Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission."

 

 

 

 

My Research Supervision

 

My Teaching