Associate Professor Luke Hunter
Associate Professor

Associate Professor Luke Hunter

  • Bachelor of Advanced Science (Honours Class 1 and University Medal), The University of Sydney, 1997-2000
  • Ph.D. in Chemistry, The University of Sydney, 2001-2004.
  • Graduate Certificate in University Learning and Teaching, UNSW, 2012-2013
Science
School of Chemistry

I completed my PhD at The University of Sydney in 2005. I then undertook a series of postdoctoral positions at The University of Melbourne, The University of St Andrews (UK) and UNSW. In 2009, my independent career commenced with the award of a University of Sydney Postdoctoral Research Fellowship. In 2011, I was appointed as a Lecturer in Chemistry at UNSW, and since then I have been promoted to Senior Lecturer (2014) and Associate Professor (2019). My research interests are broadly in the areas of organic synthesis and medicinal chemistry, with a frequent focus on fluorinated target molecules.

Phone
54474
Location
Dalton building (F12), room 221
  • Book Chapters | 2019
    Mansour F; Hunter L, 2019, '9 Synthesis and applications of backbone-fluorinated amino acids', in Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals, pp. 325 - 347, http://dx.doi.org/10.1016/b978-0-12-812733-9.00009-x
    Book Chapters | 2018
    Mansour F; Hunter L, 2018, 'Synthesis and applications of backbone-fluorinated amino acids', in Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series, pp. 325 - 347, http://dx.doi.org/10.1016/B978-0-12-812733-9.00009-X
    Book Chapters | 2017
    Brown AL; Fifer NL; Hunter L; Churches QI; Chan PWH; Cohen SB; Hutton CA, 2017, 'Total Synthesis of Ustiloxin D', in Harmata M (ed.), Strategies and Tactics in Organic Synthesis, Elsevier, pp. 169 - 191, http://dx.doi.org/10.1016/B978-0-08-100756-3.00006-6
    Book Chapters | 2016
    Brown AL; Fifer NL; Hunter L; Churches QI; Chan PWH; Cohen SB; Hutton CA, 2016, 'Chapter 6 Total Synthesis of Ustiloxin D', in , pp. 169 - 191, http://dx.doi.org/10.1016/b978-0-08-100756-3.00006-6
  • Journal articles | 2021
    Constable GEO; Jung J; Read RW; Wakelin LPG; Bhadbhade MM; Hunter L, 2021, 'Synthesis of phenazine-2,8-dicarboxylates', Arkivoc, vol. 2022, http://dx.doi.org/10.24820/ARK.5550190.P011.661
    Journal articles | 2021
    Daryl Ariawan A; Mansour F; Richardson N; Bhadbhade M; Ho J; Hunter L, 2021, 'The effect of vicinal difluorination on the conformation and potency of histone deacetylase inhibitors', Molecules, vol. 26, http://dx.doi.org/10.3390/molecules26133974
    Journal articles | 2021
    Lawer A; Hunter L, 2021, 'Controlling γ-Peptide Helicity with Stereoselective Fluorination', European Journal of Organic Chemistry, vol. 2021, pp. 1184 - 1190, http://dx.doi.org/10.1002/ejoc.202001619
    Journal articles | 2021
    Lizarme-Salas Y; Yu TT; de Bruin-Dickason C; Kumar N; Hunter L, 2021, 'Fluorinated quorum sensing inhibitors: enhancement of potency through conformational control', Organic and Biomolecular Chemistry, vol. 19, pp. 9629 - 9636, http://dx.doi.org/10.1039/d1ob01649k
    Journal articles | 2021
    Richardson NL; O'Malley LJ; Weissberger D; Tumber A; Schofield CJ; Griffith R; Jones NM; Hunter L, 2021, 'Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2', Bioorganic and Medicinal Chemistry, vol. 38, http://dx.doi.org/10.1016/j.bmc.2021.116115
    Journal articles | 2021
    Surjadinata G; Hunter L; Matesic L; Pascali G, 2021, 'Analytical-scale synthesis of aryl-SF4Cl via flow microfluidic technology', Journal of Flow Chemistry, vol. 11, pp. 107 - 115, http://dx.doi.org/10.1007/s41981-020-00130-5
    Journal articles | 2020
    Chen S; Ruan Y; Lu JL; Hunter L; Hu XG, 2020, 'Diastereoselective synthesis and conformational analysis of 4,5-difluoropipecolic acids', Organic and Biomolecular Chemistry, vol. 18, pp. 8192 - 8198, http://dx.doi.org/10.1039/d0ob01811b
    Journal articles | 2020
    Jwad R; Weissberger D; Hunter L, 2020, 'Strategies for Fine-Tuning the Conformations of Cyclic Peptides', Chemical Reviews, vol. 120, pp. 9743 - 9789, http://dx.doi.org/10.1021/acs.chemrev.0c00013
    Journal articles | 2020
    Lizarme-Salas Y; Ariawan AD; Ratnayake R; Luesch H; Finch A; Hunter L, 2020, 'Vicinal difluorination as a C=C surrogate: An analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity', Beilstein Journal of Organic Chemistry, vol. 16, pp. 2663 - 2670, http://dx.doi.org/10.3762/BJOC.16.216
    Journal articles | 2020
    Lizarme-Salas Y; Ariawan AD; Ratnayake R; Luesch H; Finch A; Hunter L, 2020, 'Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity', , http://dx.doi.org/10.3762/bxiv.2020.93.v1
    Journal articles | 2020
    Wu YM; Salas YL; Leung YC; Hunter L; Ho J, 2020, 'Predicting Octanol-Water Partition Coefficients of Fluorinated Drug-Like Molecules: A Combined Experimental and Theoretical Study', Australian Journal of Chemistry, vol. 73, pp. 677 - 685, http://dx.doi.org/10.1071/CH19648
    Journal articles | 2020
    Yeshi K; Ruscher R; Hunter L; Daly NL; Loukas A; Wangchuk P, 2020, 'Revisiting inflammatory bowel disease: Pathology, treatments, challenges and emerging therapeutics including drug leads from natural products', Journal of Clinical Medicine, vol. 9, http://dx.doi.org/10.3390/jcm9051273
    Journal articles | 2019
    2019, 'Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research (Natural Product Reports (2018) DOI: 10.1039/c7np00064b)', Natural Product Reports, vol. 36, pp. 248 - 249, http://dx.doi.org/10.1039/c8np90041h
    Journal articles | 2019
    Au C; Gonzalez C; Leung YC; Mansour F; Trinh J; Wang Z; Hu XG; Griffith R; Pasquier E; Hunter L, 2019, 'Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination', Organic and Biomolecular Chemistry, vol. 17, pp. 664 - 674, http://dx.doi.org/10.1039/c8ob02679c
    Journal articles | 2019
    Jwad RS; Pang AHC; Hunter L; Read RW, 2019, 'In pursuit of fluorinated sigma receptor ligand candidates related to [ 18 F]-FPS', Australian Journal of Chemistry, vol. 72, pp. 213 - 225, http://dx.doi.org/10.1071/CH18510
    Journal articles | 2019
    McAlpine JB; Chen SN; Kutateladze A; Macmillan JB; Appendino G; Barison A; Beniddir MA; Biavatti MW; Bluml S; Boufridi A; Butler MS; Capon RJ; Choi YH; Coppage D; Crews P; Crimmins MT; Csete M; Dewapriya P; Egan JM; Garson MJ; Genta-Jouve G; Gerwick WH; Gross H; Harper MK; Hermanto P; Hook JM; Hunter L; Jeannerat D; Ji NY; Johnson TA; Kingston DGI; Koshino H; Lee HW; Lewin G; Li J; Linington RG; Liu M; McPhail KL; Molinski TF; Moore BS; Nam JW; Neupane RP; Niemitz M; Nuzillard JM; Oberlies NH; Ocampos FMM; Pan G; Quinn RJ; Reddy DS; Renault JH; Rivera-Chávez J; Robien W; Saunders CM; Schmidt TJ; Seger C; Shen B; Steinbeck C; Stuppner H; Sturm S; Taglialatela-Scafati O; Tantillo DJ; Verpoorte R; Wang BG; Williams CM; Williams PG; Wist J; Yue JM; Zhang C; Xu Z; Simmler C; Lankin DC; Bisson J; Pauli GF, 2019, 'The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research', Natural Product Reports, vol. 36, pp. 35 - 107, http://dx.doi.org/10.1039/c7np00064b
    Journal articles | 2018
    Lawer A; Nesvaderani J; Marcolin GM; Hunter L, 2018, 'Synthesis and biochemical characterisation of fluorinated analogues of pepstatin A and grassystatin A', Tetrahedron, vol. 74, pp. 1278 - 1287, http://dx.doi.org/10.1016/j.tet.2017.12.033
    Journal articles | 2017
    Cheerlavancha R; Ahmed A; Leung YC; Lawer A; Liu QQ; Cagnes M; Jang HC; Hu XG; Hunter L, 2017, 'Homologated amino acids with three vicinal fluorines positioned along the backbone: Development of a stereoselective synthesis', Beilstein Journal of Organic Chemistry, vol. 13, pp. 2316 - 2325, http://dx.doi.org/10.3762/bjoc.13.228
    Journal articles | 2017
    Daryl Ariawan A; Webb JEA; Howe ENW; Gale PA; Thordarson P; Hunter L, 2017, 'Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate', Organic and Biomolecular Chemistry, vol. 15, pp. 2962 - 2967, http://dx.doi.org/10.1039/C7OB00316A
    Journal articles | 2017
    Hu WL; Hu XG; Hunter L, 2017, 'Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications', Synthesis (Germany), vol. 49, pp. 4917 - 4930, http://dx.doi.org/10.1055/s-0036-1590881
    Journal articles | 2017
    Konstandaras N; Matto L; Bhadbhade M; Hunter L; Harper JB, 2017, 'Synthesis and Determination of the pKa Values of a Series of Bis(anilino)furazano[3, 4-b]pyrazines', ChemistrySelect, vol. 2, pp. 7018 - 7023, http://dx.doi.org/10.1002/slct.201701674
    Journal articles | 2016
    Hu XG; Lawer A; Peterson MB; Iranmanesh H; Ball GE; Hunter L, 2016, 'Diastereoselective Synthesis and Conformational Analysis of (2R)- and (2S)-Fluorostatines: An Approach Based on Organocatalytic Fluorination of a Chiral Aldehyde', Organic Letters, vol. 18, pp. 662 - 665, http://dx.doi.org/10.1021/acs.orglett.5b03592
    Journal articles | 2016
    Lizarme Y; Wangsahardja J; Marcolin GM; Morris JC; Jones NM; Hunter L, 2016, 'Synthesis and neuroprotective activity of dictyoquinazol A and analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 1480 - 1487, http://dx.doi.org/10.1016/j.bmc.2016.02.016
    Journal articles | 2016
    Patel AR; Hu XG; Lawer A; Ahmed MI; Au C; Jwad R; Trinh J; Gonzalez C; Hannah E; Bhadbhade MM; Hunter L, 2016, 'Scalable, stereoselective syntheses of α,β-difluoro-γ-amino acids', Tetrahedron, vol. 72, pp. 3305 - 3317, http://dx.doi.org/10.1016/j.tet.2016.04.070
    Journal articles | 2016
    Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'ChemInform Abstract: Concise Synthesis of Dictyoquinazol A via a Dimerisation-Cyclocondensation Sequence.', ChemInform, vol. 47, http://dx.doi.org/10.1002/chin.201640213
    Journal articles | 2016
    Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'Concise Synthesis of Dictyoquinazol A via a Dimerisation-Cyclocondensation Sequence', Synlett, vol. 27, pp. 1237 - 1240, http://dx.doi.org/10.1055/s-0035-1561569
    Journal articles | 2015
    Absalom N; Yamamoto I; O'Hagan D; Hunter L; Chebib M, 2015, 'Probing the Mode of Neurotransmitter Binding to GABA Receptors Using Selectively Fluorinated GABA Analogues', Australian Journal of Chemistry, vol. 68, pp. 23 - 30, http://dx.doi.org/10.1071/CH14456
    Journal articles | 2015
    Hu X-G; Daryl Ariawan A; Hunter L, 2015, 'ChemInform Abstract: A D-Ribose-Derived α-Amino Nitrile as a Versatile Intermediate for the Collective Synthesis of Piperidine-Type Iminosugar C-Glycosides.', ChemInform, vol. 46, pp. no - no, http://dx.doi.org/10.1002/chin.201517263
    Journal articles | 2015
    Yap DQJ; Cheerlavancha R; Lowe R; Wang S; Hunter L, 2015, 'Investigation of cis- and trans-4-Fluoroprolines as Enantioselective Catalysts in a Variety of Organic Transformations', Australian Journal of Chemistry, vol. 68, pp. 44 - 49, http://dx.doi.org/10.1071/CH14129
    Journal articles | 2014
    Ahmed MI; Harper JB; Hunter L, 2014, 'Incrementally increasing the length of a peptide backbone: Effect on macrocyclisation efficiency', Organic and Biomolecular Chemistry, vol. 12, pp. 4598 - 4601, http://dx.doi.org/10.1039/c4ob00492b
    Journal articles | 2014
    Cheerlavancha R; Lawer A; Cagnes M; Bhadbhade M; Hunter L, 2014, 'ChemInform Abstract: Sequential Deoxyfluorination Approach for the Synthesis of Protected α,β,γ-Trifluoro-δ-amino Acids.', ChemInform, vol. 45, pp. no - no, http://dx.doi.org/10.1002/chin.201413220
    Journal articles | 2014
    Hu X-G; Hunter L, 2014, 'ChemInform Abstract: Stereoselectively Fluorinated N-Heterocycles: A Brief Survey', ChemInform, vol. 45, pp. no - no, http://dx.doi.org/10.1002/chin.201440259
    Journal articles | 2014
    Hu X-G; Thomas DS; Griffith R; Hunter L, 2014, 'Stereoselective Fluorination Alters the Geometry of a Cyclic Peptide: Exploration of Backbone-Fluorinated Analogues of Unguisin A', Angewandte Chemie, vol. 126, pp. 6290 - 6293, http://dx.doi.org/10.1002/ange.201403071
    Journal articles | 2014
    Hu XG; Daryl Ariawan A; Hunter L, 2014, 'A d-ribose-derived α-amino nitrile as a versatile intermediate for the collective synthesis of piperidine-type iminosugar C-glycosides', Tetrahedron Letters, vol. 55, pp. 7222 - 7225, http://dx.doi.org/10.1016/j.tetlet.2014.11.024
    Journal articles | 2014
    Hu XG; Thomas DS; Griffith R; Hunter L, 2014, 'Stereoselective fluorination alters the geometry of a cyclic peptide: Exploration of backbone-fluorinated analogues of unguisin a', Angewandte Chemie - International Edition, vol. 53, pp. 6176 - 6179, http://dx.doi.org/10.1002/anie.201403071
    Journal articles | 2014
    Lawer A; Tai J; Jolliffe KA; Fletcher S; Avery VM; Hunter L, 2014, 'Total synthesis and antiplasmodial activity of pohlianin C and analogues', Bioorganic and Medicinal Chemistry Letters, vol. 24, pp. 2645 - 2647, http://dx.doi.org/10.1016/j.bmcl.2014.04.071
    Journal articles | 2014
    Patel AR; Hunter L; Bhadbhade MM; Liu F, 2014, 'Conformational regulation of substituted azepanes through mono-, di-, and trifluorination', European Journal of Organic Chemistry, vol. 2014, pp. 2584 - 2593, http://dx.doi.org/10.1002/ejoc.201301811
    Journal articles | 2014
    Wang Z; Chang T; Hunter L; Gregory AM; Tanudji M; Jones S; Stenzel MH, 2014, 'Radio-opaque micelles for X-ray imaging', Australian Journal of Chemistry, vol. 67, pp. 78 - 84, http://dx.doi.org/10.1071/CH13391
    Journal articles | 2013
    Cheerlavancha R; Lawer A; Cagnes M; Bhadbhade M; Hunter L, 2013, 'Sequential deoxyfluorination approach for the synthesis of protected α,β,γ-trifluoro-δ-amino acids', Organic Letters, vol. 15, pp. 5562 - 5565, http://dx.doi.org/10.1021/ol402756e
    Journal articles | 2013
    Hu XG; Hunter L, 2013, 'Stereoselectively fluorinated N-heterocycles: A brief survey', Beilstein Journal of Organic Chemistry, vol. 9, pp. 2696 - 2708, http://dx.doi.org/10.3762/bjoc.9.306
    Journal articles | 2013
    Patel AR; Ball G; Hunter L; Liu F, 2013, 'Conformational regulation of substituted azepanes through selective monofluorination.', Org. Biomol. Chem., vol. 11, pp. 3781 - 3785, http://dx.doi.org/10.1039/c3ob40391b
    Journal articles | 2012
    Harty D; Farahani RMZ; Simonian MR; Hunter L; Hunter N, 2012, 'Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the áC region and cleavage of the N-terminal region of the Bâ chains of fibrinogen', Thrombosis and Haemostasis, vol. 108, pp. 236 - 246, http://dx.doi.org/10.1160/TH12-01-0032
    Journal articles | 2012
    Hunter L, 2012, 'α,β-Difluoro-γ-amino acids: synthesis and applications', Chimica Oggi-Chemistry Today, vol. 30, pp. 20 - 22
    Journal articles | 2012
    Hunter L, 2012, 'ChemInform Abstract: α,β-Difluoro-γ-amino Acids - Synthesis and Applications', ChemInform, vol. 43, pp. no - no, http://dx.doi.org/10.1002/chin.201243251
    Journal articles | 2012
    Journal articles | 2012
    Hunter L, 2012, 'α,β-difluoro-γ-amino acids synthesis and applications', Chimica Oggi/Chemistry Today, vol. 30, pp. 20 - 22
    Journal articles | 2012
    Hunter L; Butler SL; Ludbrook SB, 2012, 'Solid phase synthesis of peptides containing backbone-fluorinated amino acids', Organic and Biomolecular Chemistry, vol. 10, pp. 8911 - 8918, http://dx.doi.org/10.1039/c2ob26596f
    Journal articles | 2012
    Wang Z; Hunter L, 2012, 'Synthesis of difluorinated β- and γ-amino acids: Investigation of a challenging deoxyfluorination reaction', Journal of Fluorine Chemistry, vol. 143, pp. 143 - 147, http://dx.doi.org/10.1016/j.jfluchem.2012.06.016
    Journal articles | 2012
    Yamamoto I; Jordan MA; Gavande N; Doddareddy M; Chebib M; Hunter L, 2012, 'The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor', Chemical Communications, vol. 48, pp. 829 - 831, http://dx.doi.org/10.1039/C1CC15816C
    Journal articles | 2011
    Hunter L; Chung J, 2011, 'Total synthesis of unguisin A', Journal of Organic Chemistry, vol. 76, pp. 5502 - 5505, http://dx.doi.org/10.1021/jo200813a
    Journal articles | 2011
    Hunter L; Condie GC; Harding MM, 2011, 'ChemInform Abstract: Reversible Aqueous Metathesis Reactions for Potential Application in Dynamic Combinatorial Chemistry.', ChemInform, vol. 42, pp. no - no, http://dx.doi.org/10.1002/chin.201102054
    Journal articles | 2011
    Hunter L; Jolliffe KA; Jordan M; Jensen P; Macquart R, 2011, 'Synthesis and Conformational Analysis of á,â-Difluoro-ã-amino Acid Derivatives', Chemistry - a European Journal, vol. 17, pp. 2340 - 2343, http://dx.doi.org/10.1002/chem.201003320
    Journal articles | 2010
    Hunter L, 2010, 'ChemInform Abstract: The C-F- Bond as a Conformational Tool in Organic and Biological Chemistry', ChemInform, vol. 41, pp. no - no, http://dx.doi.org/10.1002/chin.201041259
    Journal articles | 2010
    Hunter L, 2010, 'The C-F bond as a conformational tool in organic and biomolecular chemistry', Beilstein Journal of Organic Chemistry, vol. 6, http://dx.doi.org/10.3762/bjoc.6.38
    Journal articles | 2010
    Hunter L; Condie G; Harding MM, 2010, 'Reversible aqueous metathesis reactions for potential application in dynamic combinatorial chemistry', Tetrahedron Letters, vol. 51, pp. 5064 - 5067, http://dx.doi.org/10.1016/j.tetlet.2010.07.105
    Journal articles | 2009
    Hunter L; Kirsch P; Slawin AMZ; O'Hagan D, 2009, 'Synthesis and Structure of Stereoisomeric Multivicinal Hexafluoroalkanes', Angewandte Chemie, vol. 121, pp. 5565 - 5568, http://dx.doi.org/10.1002/ange.200901956
    Journal articles | 2009
    Hunter L; Kirsch P; Slawin AMZ; O'Hagan D, 2009, 'Synthesis and Structure of Stereoisomeric Multivicinal Hexafluoroalkanes.', Angew. Chem., Int. Ed., vol. 48, pp. 5457 - S5457/63, http://dx.doi.org/10.1002/anie.200901956
    Journal articles | 2008
    Hunter L; Kirsch P; Hamilton JTG; O'Hagan D, 2008, 'The multi-vicinal fluoroalkane motif: an examination of 2,3,4,5-tetrafluorohexane stereoisomers.', Org. Biomol. Chem., vol. 6, pp. 3105 - 3108, http://dx.doi.org/10.1039/b807449f
    Journal articles | 2008
    Hunter L; O'Hagan D, 2008, 'ChemInform Abstract: Multi-vicinal Fluoroalkanes: A New Class of Organofluorine Compounds', ChemInform, vol. 39, http://dx.doi.org/10.1002/chin.200847242
    Journal articles | 2008
    Hunter L; O'Hagan D, 2008, 'Multi-vicinal fluoroalkanes: a new class of organofluorine compounds.', Org. Biomol. Chem., vol. 6, pp. 2843 - 2848, http://dx.doi.org/10.1039/b809432b
    Journal articles | 2007
    Hunter L; Slawin AMZ; Kirsch P; O'Hagan D, 2007, 'Synthesis and Conformation of Multi-Vicinal Fluoroalkane Diastereoisomers', Angewandte Chemie, vol. 119, pp. 8033 - 8036, http://dx.doi.org/10.1002/ange.200701988
    Journal articles | 2007
    Hunter L; Slawin AMZ; Kirsch P; O'Hagan D, 2007, 'Synthesis and conformation of multi-vicinal fluoroalkane diastereoisomers.', Angew. Chem., Int. Ed., vol. 46, pp. 7887 - 7890, http://dx.doi.org/10.1002/anie.200701988
    Journal articles | 2006
    Hunter L; O'Hagan D; Slawin AMZ, 2006, 'Enantioselective synthesis of an all-syn four vicinal fluorine motif', Journal of the American Chemical Society, vol. 128, pp. 16422 - 16423, http://dx.doi.org/10.1021/ja066188p
    Journal articles | 2005
    Hunter L; McLeod MD; Hutton CA, 2005, 'Synthesis of the β-Hydroxydopa—y-Hydroxy-δ-sulfinylnorvaline (I) Component of Ustiloxins A and B (II).', ChemInform, vol. 36, http://dx.doi.org/10.1002/chin.200533223
    Journal articles | 2005
    Hunter L; McLeod MD; Hutton CA, 2005, 'Synthesis of the β-hydroxydopa-γ-hydroxy-δ-sulfinylnorvaline component of ustiloxins A and B.', Org. Biomol. Chem., vol. 3, pp. 732 - 734, http://dx.doi.org/10.1039/b418876d
    Journal articles | 2004
    Hunter L; Hutton CA, 2004, 'Preparation of Selectively Protected L-Dopa Derivatives: Oxidation of Tyrosine-3-boronates.', ChemInform, vol. 35, http://dx.doi.org/10.1002/chin.200412210
    Journal articles | 2004
    Hutchins LM; Hunter L; Ehya N; Gibbs MD; Bergquist PL; Hutton CA, 2004, 'Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp', Tetrahedron Asymmetry, vol. 15, pp. 2975 - 2980, http://dx.doi.org/10.1016/j.tetasy.2004.07.041
    Journal articles | 2003
    Hunter L; Hutton CA, 2003, 'Preparation of Selectively Protected L-DOPA Derivatives: Oxidation of Tyrosine-3-boronates.', Aust. J. Chem., vol. 56, pp. 1095 - 1098, http://dx.doi.org/10.1071/CH03181
    Journal articles | 2002
    Sunna A; Hunter L; Hutton CA; Bergquist PL, 2002, 'Biochemical characterization of a recombinant thermoalkalophilic lipase and assessment of its substrate enantioselectivity.', Enzyme Microb. Technol., vol. 31, pp. 472 - 476, http://dx.doi.org/10.1016/S0141-0229(02)00133-3
  • Conference Presentations | 2017
    Colbran S; Hunter L; Lapere K; Prescott SW; Sulway S; Yannoulatos S, 2017, '"Basic" vs "Expert" knowledge: a new paradigm in chemistry assessment', presented at RACI100 Congress, Melbourne, -
    Other | 2015
    Hunter L, 2015, Fluorine Chemistry, http://dx.doi.org/10.1071/CH14583
    Conference Papers | 2012
    Hunter L, 2012, 'Fluorinated amino acids: Building blocks for the synthesis of shape-controlled bioactive peptides', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, San Diego, CA, presented at 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS), San Diego, CA, 25 March 2012 - 29 March 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324475105362&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

RESEARCH GRANTS:

  • Cooperative Research Centres Projects (CRC-P) (2020–2022): $3,000,000
  • ARC Discovery Project (2018–2020): $416,584
  • ARC Discovery Project (2014–2016): $345,000
  • ARC Discovery Early Career Research Award (2012–2014): $375,000
  • UNSW Major Research Equipment Grant (2013): $90,000
  • UNSW Faculty Research Grant Program (2018): $20,000
  • UNSW Faculty Research Grant Program (2016): $20,000
  • UNSW Faculty of Science Interdisciplinary Research Grant (2013): $3,000
  • University of Sydney Postdoctoral Research Fellowship (2009–2011): $300,00

TEACHING GRANTS:

  • ARC Industrial Transformation Training Centre (2018–2023): $3,279,502
  • UNSW Learning & Teaching Strategic Development and Enhancement Funding (2018–2019): $200,000
  • UNSW Learning & Teaching Strategic Development and Enhancement Funding (2014–2015): $200,000
  • UNSW Learning & Teaching Innovation Grant (2015): $20,000
  • UNSW Learning & Teaching Innovation Grant (2014): $25,000

  • 2018 Vice-Chancellor's Award for Teaching Excellence
  • 2016 Vice-Chancellor's Award for Teaching Excellence
  • 2017 Fellow of the UNSW Scientia Education Academy (5-year term)
  • 2015 Tasmanian Alkaloids Lectureship
  • 2012 ARC Discovery Early Career Researcher Award (DECRA)
  • 2009 University of Sydney Postdoctoral Research Fellowship
  • 2000 University Medal

Research in the Hunter group focuses on natural products chemistry, peptidomimetics, bioactive molecules and synthetic methodology. A strong theme of organofluorine chemistry underpins several of these research areas. 

Fluorine is a small element that packs a big punch. When fluorine atoms are incorporated into organic molecules, they can have a dramatic impact on the substances' physical and chemical properties, and this leads to a wealth of applications in pharmaceuticals, agrochemicals, liquid crystals and polymers. In the Hunter group we are particularly interested in developing new methods to synthesise organofluorine compounds, and in using fluorine atoms to control molecular conformation (a kind of "molecular origami"). The highly polarised C-F bond tends to align in very particular ways with adjacent functional groups, due to a variety of subtle stereoelectronic effects. In our lab, we harness these effects to produce novel bioactive molecules that are constrained into optimal 3D shapes, controlled by the precise positioning of fluorine atoms. The research is interdisciplinary in nature, and we collaborate extensively to analyse the biological properties of the molecules that we create.