Professor Lynne Bilston
Senior Research Fellow

Professor Lynne Bilston

Medicine & Health
School of Clinical Medicine

Research Interests:
From a background in biomechanical engineering, the focus of my research is on how the nervous system responds to mechanical loading - both those loads which cause injury and those which are part of normal function. Our approach spans the range from the whole body (e.g crash testing) through individual tissues, and down to a molecular scale - integrating the data to gain an understanding of the detailed mechanisms of nervous system injury and mechanically influenced physiological functions.

I use novel imaging techniques such as tagged MRI and MR elastography to study a diverse range of in vivo mechanical functions, including obstructive sleep apnoea,muscle injury, biomechanical properties of tissues during growth and development, neural tissue mechanics, syringomyelia and hydrocephalus.

Broad Research Areas:
Injury, Biomedical Engineering, Neurotrauma, Imaging / Radiology, Population Health, Biomechanics

Society Memberships & Professional Activities:
Chair, Australian Standards Committee for Child Restraints, ISMRM, Australasian Sleep Association, Australian and New Zealand Society of Biomechanics, Fellow of Academy of Health and Medical Sciences

Specific Research Keywords:
Imaging, Neural Injury, Biomechanics, Road Safety, Syringomyelia, Sleep Apnoea

Phone
93991673
Location
Neuroscience Research Australia
  • Journal articles | 2022
    Carberry JC; Burke PGR; Osman AM; Jugé L; Toson B; Gandevia SC; Butler JE; Bilston LE; Eckert DJ, 2022, 'Regional genioglossus reflex responses to negative pressure pulses in people with obstructive sleep apnea', Journal of applied physiology (Bethesda, Md. : 1985), vol. 133, pp. 755 - 765, http://dx.doi.org/10.1152/japplphysiol.00083.2021
    Journal articles | 2022
    Jugé L; Foley P; Hatt A; Yeung J; Bilston LE, 2022, 'Ex vivo bovine liver nonlinear viscoelastic properties: MR elastography and rheological measurements', Journal of the Mechanical Behavior of Biomedical Materials, pp. 105638 - 105638, http://dx.doi.org/10.1016/j.jmbbm.2022.105638
    Journal articles | 2022
    Jugé L; Knapman FL; Humburg P; Burke PGR; Lowth AB; Brown E; Butler JE; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2022, 'The relationship between mandibular advancement, tongue movement, and treatment outcome in obstructive sleep apnea', Sleep, vol. 45, http://dx.doi.org/10.1093/sleep/zsac044
    Journal articles | 2022
    Jugé L; Liao A; Yeung J; Knapman F; Burke P; Brown E; Gandevia S; Eckert D; Butler J; Bilston L, 2022, 'O054 Genioglossus neural drive and upper airway dilation in people with obstructive sleep apnoea during wakefulness', SLEEP Advances, vol. 3, pp. A23 - A23, http://dx.doi.org/10.1093/sleepadvances/zpac029.053
    Journal articles | 2022
    Lloyd RA; Stoodley MA; Bilston LE, 2022, 'Statistical shape models of the posterior cranial fossa and hindbrain volumes may provide a more robust clinical metric for Chiari malformation', Journal of Biomechanics, vol. 137, http://dx.doi.org/10.1016/j.jbiomech.2022.111093
    Journal articles | 2021
    Babaei B; Fovargue D; Lloyd RA; Miller R; Jugé L; Kaplan M; Sinkus R; Nordsletten DA; Bilston LE, 2021, 'Magnetic Resonance Elastography Reconstruction for Anisotropic Tissues', Medical Image Analysis, vol. 74, http://dx.doi.org/10.1016/j.media.2021.102212
    Journal articles | 2021
    Brown EC; Jugé L; Knapman FL; Burke PGR; Ngiam J; Sutherland K; Butler JE; Eckert DJ; Cistulli PA; Bilston LE, 2021, 'Mandibular advancement splint response is associated with the pterygomandibular raphe', Sleep, vol. 44, http://dx.doi.org/10.1093/sleep/zsaa222
    Journal articles | 2021
    Jugé L; Olsza I; Knapman FL; Burke PGR; Brown EC; Stumbles E; De Frescheville AFB; Gandevia SC; Eckert DJ; Butler JE; Bilston LE, 2021, 'Effect of upper airway fat on tongue dilation during inspiration in awake people with obstructive sleep apnea', Sleep, vol. 44, http://dx.doi.org/10.1093/sleep/zsab192
    Journal articles | 2021
    Jugé L; Yeung J; Knapman FL; Burke PGR; Lowth AB; Gan KZC; Brown EC; Butler JE; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2021, 'Influence of mandibular advancement on tongue dilatory movement during wakefulness and how this is related to oral appliance therapy outcome for obstructive sleep apnea', Sleep, vol. 44, http://dx.doi.org/10.1093/sleep/zsaa196
    Journal articles | 2020
    Jugé L; Knapman FL; Burke PGR; Brown E; Bosquillon de Frescheville AF; Gandevia SC; Eckert DJ; Butler JE; Bilston LE, 2020, 'Regional respiratory movement of the tongue is coordinated during wakefulness and is larger in severe obstructive sleep apnoea', Journal of Physiology, vol. 598, pp. 581 - 597, http://dx.doi.org/10.1113/JP278769
    Journal articles | 2019
    Kwan BCH; Jugé L; Gandevia SC; Bilston LE, 2019, 'Sagittal Measurement of Tongue Movement During Respiration: Comparison Between Ultrasonography and Magnetic Resonance Imaging', Ultrasound in Medicine and Biology, vol. 45, pp. 921 - 934, http://dx.doi.org/10.1016/j.ultrasmedbio.2018.12.003
    Journal articles | 2019
    Tong J; Juge L; Burke PGR; Knapman F; Eckert DJ; Bilston LE; Amatoury J, 2019, 'Respiratory-related displacement of the trachea in obstructive sleep apnea', Journal of Applied Physiology, vol. 127, pp. 1307 - 1316, http://dx.doi.org/10.1152/japplphysiol.00660.2018
    Journal articles | 2019
    Yeung J; Jugé L; Hatt A; Bilston LE, 2019, 'Paediatric brain tissue properties measured with magnetic resonance elastography', Biomechanics and Modeling in Mechanobiology, vol. 18, pp. 1497 - 1505, http://dx.doi.org/10.1007/s10237-019-01157-x
    Journal articles | 2018
    Tan K; Jugé L; Hatt A; Cheng S; Bilston LE, 2018, 'Measurement of large strain properties in calf muscles in vivo using magnetic resonance elastography and spatial modulation of magnetization', NMR in Biomedicine, vol. 31, http://dx.doi.org/10.1002/nbm.3925
    Journal articles | 2017
    Adam A; Robison J; Lu J; Jose R; Badran N; Vivas-Buitrago T; Rigamonti D; Sattar A; Omoush O; Hammad M; Dawood M; Maghaslah M; Belcher T; Carson K; Hoffberger J; Jusué Torres I; Foley S; Yasar S; Thai QA; Wemmer J; Klinge P; Al-Mutawa L; Al-Ghamdi H; Carson KA; Asgari M; de Zélicourt D; Kurtcuoglu V; Garnotel S; Salmon S; Balédent O; Lokossou A; Page G; Balardy L; Czosnyka Z; Payoux P; Schmidt EA; Zitoun M; Sevestre MA; Alperin N; Baudracco I; Craven C; Matloob S; Thompson S; Haylock Vize P; Thorne L; Watkins LD; Toma AK; Bechter K; Pong AC; Jugé L; Bilston LE; Cheng S; Bradley W; Hakim F; Ramón JF; Cárdenas MF; Davidson JS; García C; González D; Bermudez S; Useche N; Mejía JA; Mayorga P; Cruz F; Martinez C; Matiz MC; Vallejo M; Ghotme K; Soto HA; Riveros D; Buitrago A; Mora M; Murcia L; Cohen D; Dasgupta D; Curtis C; Domínguez L; Remolina AJ; Grijalba MA; Whitehouse KJ; Edwards RJ; Eleftheriou A; Lundin F; Fountas KN; Kapsalaki EZ; Smisson HF; Robinson JS; Fritsch MJ; Arouk W; Garzon M; Kang M; Sandhu K; Baghawatti D; Aquilina K; James G; Thompson D; Gehlen M; Schmid Daners M; Eklund A, 2017, 'Abstracts from Hydrocephalus 2016', Fluids and barriers of the CNS, vol. 14, pp. 15, http://dx.doi.org/10.1186/s12987-017-0054-5
    Journal articles | 2017
    Etchell E; Jugé L; Hatt A; Sinkus R; Bilston LE, 2017, 'Liver stiffness values are lower in pediatric subjects than in adults and increase with age: A multifrequency MR elastography study', Radiology, vol. 283, pp. 222 - 230, http://dx.doi.org/10.1148/radiol.2016160252
    Journal articles | 2017
    Pong AC; Jugé L; Bilston LE; Cheng S, 2017, 'Development of acute hydrocephalus does not change brain tissue mechanical properties in adult rats, but in juvenile rats', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0182808
    Journal articles | 2017
    Rad ZF; Nordon RE; Anthony CJ; Bilston L; Prewett PD; Arns JY; Arns CH; Zhang L; Davies GJ, 2017, 'High-fidelity replication of thermoplastic microneedles with open microfluidic channels', Microsystems and Nanoengineering, vol. 3, http://dx.doi.org/10.1038/micronano.2017.34
    Journal articles | 2016
    Farnoush A; Tan K; Juge L; Bilston LE; Cheng S, 2016, 'Effect of endoscopic third ventriculostomy on cerebrospinal fluid pressure in the cerebral ventricles', Journal of Clinical Neuroscience, vol. 23, pp. 63 - 67, http://dx.doi.org/10.1016/j.jocn.2015.04.025
    Journal articles | 2016
    Jugé L; Pong AC; Bongers A; Sinkus R; Bilston LE; Cheng S, 2016, 'Changes in rat brain tissue microstructure and stiffness during the development of experimental obstructive hydrocephalus', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0148652
    Journal articles | 2016
    Pong AC; Jugé L; Cheng S; Bilston LE, 2016, 'Longitudinal measurements of postnatal rat brain mechanical properties in-vivo', Journal of Biomechanics, vol. 49, pp. 1751 - 1756, http://dx.doi.org/10.1016/j.jbiomech.2016.04.005
    Journal articles | 2015
    Herbert RD; Héroux ME; Diong J; Bilston LE; Gandevia SC; Lichtwark GA, 2015, 'Changes in the length and three-dimensional orientation of muscle fascicles and aponeuroses with passive length changes in human gastrocnemius muscles', Journal of Physiology, vol. 593, pp. 441 - 455, http://dx.doi.org/10.1113/jphysiol.2014.279166
    Journal articles | 2015
    Jugé L; Petiet A; Lambert SA; Nicole P; Chatelin S; Vilgrain V; Van Beers BE; Bilston LE; Sinkus R, 2015, 'Microvasculature alters the dispersion properties of shear waves - a multi-frequency MR elastography study', NMR in Biomedicine, vol. 28, pp. 1763 - 1771, http://dx.doi.org/10.1002/nbm.3438
    Journal articles | 2015
    Lambert SA; Näsholm SP; Nordsletten D; Michler C; Juge L; Serfaty JM; Bilston L; Guzina B; Holm S; Sinkus R, 2015, 'Bridging Three Orders of Magnitude: Multiple Scattered Waves Sense Fractal Microscopic Structures via Dispersion', Physical Review Letters, vol. 115, http://dx.doi.org/10.1103/PhysRevLett.115.094301
    Journal articles | 2015
    Roberts JJ; Naudiyal P; Jugé L; Bilston LE; Granville AM; Martens PJ, 2015, 'Tailoring Stimuli Responsiveness using Dynamic Covalent Cross-Linking of Poly(vinyl alcohol)-Heparin Hydrogels for Controlled Cell and Growth Factor Delivery', ACS Biomaterials Science and Engineering, vol. 1, pp. 1267 - 1277, http://dx.doi.org/10.1021/acsbiomaterials.5b00321
    Journal articles | 2015
    Tan K; Cheng S; Jugé L; Bilston LE, 2015, 'Characterising skeletal muscle under large strain using eccentric and Fourier Transform-rheology', Journal of Biomechanics, vol. 48, pp. 3788 - 3795, http://dx.doi.org/10.1016/j.jbiomech.2015.08.025
    Journal articles | 2014
    Qin EC; Jugé L; Lambert SA; Paradis V; Sinkus R; Bilston LE, 2014, 'In vivo anisotropic mechanical properties of dystrophic skeletal muscles measured by anisotropic MR elastographic imaging: The mdx mouse model of muscular dystrophy', Radiology, vol. 273, pp. 726 - 735, http://dx.doi.org/10.1148/radiol.14132661
    Journal articles | 2013
    Tan KT; Cheng SK; Juge L; Bilston LE, 2013, 'Characterising soft tissues under large amplitude oscillatory shear and combined loading', Journal of Biomechanics, vol. 46, pp. 1060 - 1066, http://dx.doi.org/10.1016/j.jbiomech.2013.01.028
  • Conference Abstracts | 2021
    Brereton C; Ferreira A; Juge L; Bilston L; Brown E, 2021, 'P013 A pilot study for ultrasound examination of the pterygomandibular raphe to predict efficacy of mandibular advancement splint therapy in obstructive sleep apnoea', in SLEEP Advances, Oxford University Press (OUP), Vol. 2, pp. A25 - A26, http://dx.doi.org/10.1093/sleepadvances/zpab014.061
    Conference Abstracts | 2021
    Jugé L; Knapman F; Humburg P; Burke P; Lowth A; Brown E; Butler J; Eckert D; Ngiam J; Sutherland K; Cistulli P; Bilston L, 2021, 'Pharyngeal enlargement via tongue advancement differs with mandibular advancement therapy response and improves treatment prediction', in SLEEP Advances, Oxford University Press (OUP), Vol. 2, pp. A11 - A12, http://dx.doi.org/10.1093/sleepadvances/zpab014.025
    Conference Abstracts | 2020
    Bilston L; Juge L; Knapman F; Yeung J; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA, 2020, 'Mandibular Advancement Splint Treatment Outcome Is Related to the Interaction Between Airway Enlargement and Dilatory Muscle Function with Mandibular Advancement', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, ELECTR NETWORK, Vol. 201, presented at International Conference of the American-Thoracic-Society (ATS), ELECTR NETWORK, 10 November 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000556622802499&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Brown L; Juge L; Burke P; Sutherland K; Eckert DJ; Cistulli PA; Bilston LE, 2019, 'Mandibular advancement splint efficacy is higher but tolerance lower in people without lateral wall tendon', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Sydney, Vol. 28, presented at 31st Annual Scientific Meeting (ASM) of the Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Sydney, 16 October 2019 - 19 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489047200071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Brown L; Juge L; Burke P; Sutherland K; Eckert DJ; Cistulli PA; Bilston LE, 2019, 'Mandibular advancement splint efficacy is higher but tolerance lower in people without lateral wall tendon', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Sydney, Vol. 28, presented at 31st Annual Scientific Meeting (ASM) of the Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Sydney, 16 October 2019 - 19 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489047200146&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Juge L; Yeung J; Knapman F; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2019, 'Altered inspiratory airway dilation patterns with mandibular advancement splints may help predict treatment outcomes', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Sydney, Vol. 28, presented at 31st Annual Scientific Meeting (ASM) of the Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Sydney, 16 October 2019 - 19 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489047200032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Juge L; Yeung J; Knapman F; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2019, 'HOW MANDIBULAR ADVANCEMENT SPLINTS ALTER GENIOGLOSSUS AIRWAY DILATION PATTERNS DURING INSPIRATION IN AWAKE PEOPLE WITH OBSTRUCTIVE SLEEP APNOEA MAY HELP PREDICT TREATMENT OUTCOMES', in SLEEP MEDICINE, ELSEVIER, Vol. 64, pp. S38 - S38, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000558768400104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Brown L; Juge L; Burke P; Sutherland K; Cistulli P; Bilston L, 2018, 'How lateral airway tissues affect upper airway dimensions with mandibular advancement in obstructive sleep apnoea.', in EUROPEAN RESPIRATORY JOURNAL, EUROPEAN RESPIRATORY SOC JOURNALS LTD, FRANCE, Paris, Vol. 52, presented at 28th International Congress of the European-Respiratory-Society (ERS), FRANCE, Paris, 15 September 2018 - 19 September 2018, http://dx.doi.org/10.1183/13993003.congress-2018.OA5369
    Conference Abstracts | 2018
    Juge L; Knapman F; Burke P; Brown E; Butler J; Eckert DJ; Ngiam J; Sutherland K; Cistulli PA; Bilston LE, 2018, 'Can Tongue Deformation During Mandibular Advancement Help to Predict Mandibular Advancement Treatment Outcomes?', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, CA, San Diego, Vol. 197, presented at International Conference of the American-Thoracic-Society, CA, San Diego, 18 May 2018 - 23 May 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449978905472&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Juge L; Knapman F; Burke P; Brown E; Gandevia S; Eckert D; Butler J; Bilston L, 2018, 'Variation in horizontal and oblique genioglossus dilatory motion during inspiration in obstructive sleep apnoea', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Brisbane, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100196&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Juge L; Knapman F; Eckert D; Burke P; Brown E; Butler J; Ngiam J; Sutherland K; Cistulli P; Bilston L, 2018, 'Tongue deformation during mandibular advancement may help to predict mandibular advancement treatment outcome in obese patients with obstructive sleep apnoea', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Brisbane, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100156&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Lowth A; Juge L; Knapman F; Burke P; Brown E; Butler J; Eckert D; Ngiam J; Cistulli P; Bilston L; Sutherland K, 2018, 'Dynamic MRI tongue deformation patterns during mandibular advancement and associations with craniofacial anatomy in OSA', in JOURNAL OF SLEEP RESEARCH, WILEY, AUSTRALIA, Brisbane, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), AUSTRALIA, Brisbane, 17 October 2018 - 20 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100108&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Kwan B; Juge L; Bilston L; Gandevia S, 2017, 'SAGITTAL MEASUREMENT OF GENIOGLOSSUS MOVEMENT DURING RESPIRATION: COMPARISON BETWEEN ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGING', in SLEEP MEDICINE, ELSEVIER SCIENCE BV, Vol. 40, pp. E175 - E175, http://dx.doi.org/10.1016/j.sleep.2017.11.512
    Conference Abstracts | 2016
    Juge ; Pong ; Bongers A; Sinkus ; Cheng ; Bilston , 2016, 'A step towards developing MR elastography and diffusion tensor imaging as complementary MR tools to improve the management of hydrocephalus', in A step towards developing MR elastography and diffusion tensor imaging as complementary MR tools to improve the management of hydrocephalus, 2016 Annual Meeting ISMRM, Singapore, presented at 2016 Annual Meeting ISMRM, Singapore, 07 May 2016 - 13 May 2016
    Conference Papers | 2015
    Juge L; Pong A; Bongers A; Sinkus R; Bilston L; Cheng S, 2015, 'Deformation, microstructure and stiffness of the rat brain tissue during the development of experimental obstructive hydrocephalus', in Deformation, microstructure and stiffness of the rat brain tissue during the development of experimental obstructive hydrocephalus, Hydrocephalus, Banff, Alberta, Canada, presented at Hydrocephalus

My Research Supervision

I am currently supervising ILP, Honours, Masters by Research, and PhD students.