Dr Maria   Tsoli
Conjoint Senior Lecturer

Dr Maria Tsoli

  • BSc (Honours Microbiology & Immunology) 1999, University of New South Wales, Australia
  • PhD Cancer Biology & Molecular Modelling, 2004, University of Duisburg-Essen, Germany
Medicine & Health
Sch Women's&Children's Health

Dr Tsoli has a PhD in Cancer Cell Biology and Molecular Modelling, in which she examined the anticancer potential of gold-based nanoparticles. She subsequently accepted postdoctoral positions at the ANZAC Research Institute/USYD and Sanford-Burnham Institute/USA where she focused on elucidating signalling pathways involved in the development of cancer cachexia syndrome (CCS) and paediatric bone disorder hypophosphatasia. She is currently leading the Brain Tumour Group at the Children’s Cancer Institute (CCI) under the mentorship of A/Prof Ziegler. She is the lead scientist responsible for establishing state of the art techniques for research in Diffuse Intrinsic Pontine Gliomas (DIPG) and the development of glioma PDX models as part of the national PRecISion Medicine for Children with Cancer trial (PRISM). Key achievements include the (a) establishment of primary brain tumour neurospheres (DIPG, glioblastoma, medulloblastoma) and orthotopic animal models from paediatric overseas and Australian patient’s biopsies/ autopsies; and (b) establishment of single-agent and combination high-throughput screening performed on primary DIPG neurosphere-forming cells. Dr Tsoli is also responsible for the research direction of multiple DIPG projects, laboratory management, and is committed to developing the expertise and careers of junior research staff in the program exhibited by her supervision of research staff (currently 1 PhD student, 5 research assistants and 3 postdocs).

Phone
02 938 52146
Location
Children's Cancer Institute Lowy Cancer Research Centre, UNSW Australia PO Box 81 Randwick 2031 Australia http://ccia.org.au

Publications

  • Journal articles | 2021
    Dr Maria Tsoli
    Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Hayden E; Rouaen J; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Kankean A; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov A; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG', NEURO-ONCOLOGY, vol. 23, pp. 18 - 19, http://dx.doi.org/10.1093/neuonc/noab090.075
    Journal articles | 2021
    Dr Maria Tsoli
    Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Joshi S; Rouaen JRC; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Tolhurst O; Kankean A; Hayden E; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov AV; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG', Cell Reports, vol. 35, pp. 108994 - 108994, http://dx.doi.org/10.1016/j.celrep.2021.108994
    Journal articles | 2021
    Dr Maria Tsoli
    Khan A; Gamble LD; Upton DH; Ung C; Yu DMT; Ehteda A; Pandher R; Mayoh C; Hébert S; Jabado N; Kleinman CL; Burns MR; Norris MD; Haber M; Tsoli M; Ziegler DS, 2021, 'Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas', Nature Communications, vol. 12, pp. 971, http://dx.doi.org/10.1038/s41467-021-20896-z
    Journal articles | 2021
    Dr Maria Tsoli
    Upton D; George S; Liu J; Cai D; Su SY-C; Manoharan N; Foresto S; Hassall T; Tsoli M; Ziegler D, 2021, 'ACT001-A PROMISING THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', NEURO-ONCOLOGY, vol. 23, pp. 20 - 20, http://dx.doi.org/10.1093/neuonc/noab090.080
    Journal articles | 2021
    Dr Maria Tsoli
    Xie J; Kumar A; Dolman MEM; Mayoh C; Khuong-Quang DA; Cadiz R; Wong-Erasmus M; Mould EVA; Grebert-Wade D; Barahona P; Kamili A; Tsoli M; Failes TW; Chow SO; Bhatia K; Marshall GM; Ziegler DS; Haber M; Lock RB; Tyrrell V; Lau L; Athanasatos P; Gifford AJ, 2021, 'The important role of routine cytopathology in pediatric precision oncology', Cancer Cytopathology, http://dx.doi.org/10.1002/cncy.22448
    Journal articles | 2021
    Dr Maria Tsoli
    Khan A; Gamble L; Upton D; Yu D; Pandher R; Mayoh C; Burns MR; Norris MD; Haber M; Tsoli M; Ziegler DS, 2021, 'POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', NEURO-ONCOLOGY, vol. 23, pp. 40 - 41, http://dx.doi.org/10.1093/neuonc/noab090.163
    Journal articles | 2021
    Dr Maria Tsoli
    Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Reynolds P; Tsoli M; Ziegler D, 2021, 'RARE-08. POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS IDENTIFIED THROUGH HIGH THROUGHPUT DRUG SCREENING', Neuro-Oncology, vol. 23, pp. i42 - i42, http://dx.doi.org/10.1093/neuonc/noab090.169
    Journal articles | 2021
    Dr Maria Tsoli
    Ung C; Upton D; Tsoli M; Ziegler D, 2021, 'HGG-10. THE BLOOD-BRAIN BARRIER IN DIPG: INVESTIGATING REGION-SPECIFIC DIFFERENCES IN PERMEABILITY', Neuro-Oncology, vol. 23, pp. i19 - i19, http://dx.doi.org/10.1093/neuonc/noab090.076
    Journal articles | 2021
    Dr Maria Tsoli
    Ung C; Tsoli M; Liu J; Cassano D; Pocoví-Martínez S; Upton DH; Ehteda A; Mansfeld FM; Failes TW; Farfalla A; Katsinas C; Kavallaris M; Arndt GM; Vittorio O; Cirillo G; Voliani V; Ziegler DS, 2021, 'Doxorubicin-loaded gold nanoarchitectures as a therapeutic strategy against diffuse intrinsic pontine glioma', Cancers, vol. 13, pp. 1 - 20, http://dx.doi.org/10.3390/cancers13061278
    Journal articles | 2020
    Dr Maria Tsoli
    Shen H; Yu M; Tsoli M; Chang C; Joshi S; Liu J; Ryall S; Chornenkyy Y; Siddaway R; Hawkins C; Ziegler DS, 2020, 'Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas', Neuro-Oncology, vol. 22, pp. 139 - 151, http://dx.doi.org/10.1093/neuonc/noz140
    Journal articles | 2020
    Dr Maria Tsoli
    Clarke M; Mackay A; Ismer B; Pickles JC; Tatevossian RG; Newman S; Bale TA; Stoler I; Izquierdo E; Temelso S; Carvalho DM; Molinari V; Burford A; Howell L; Virasami A; Fairchild AR; Avery A; Chalker J; Kristiansen M; Haupfear K; Dalton JD; Orisme W; Wen J; Hubank M; Kurian KM; Rowe C; Maybury M; Crosier S; Knipstein J; Schüller U; Kordes U; Kram DE; Snuderl M; Bridges L; Martin AJ; Doey LJ; Al-Sarraj S; Chandler C; Zebian B; Cairns C; Natrajan R; Boult JKR; Robinson SP; Sill M; Dunkel IJ; Gilheeney SW; Rosenblum MK; Hughes D; Proszek PZ; Macdonald TJ; Preusser M; Haberler C; Slavc I; Packer R; Ng HK; Caspi S; Popović M; Kotnik BF; Wood MD; Baird L; Davare MA; Solomon DA; Olsen TK; Brandal P; Farrell M; Cryan JB; Capra M; Karremann M; Schittenhelm J; Schuhmann MU; Ebinger M; Dinjens WNM; Kerl K; Hettmer S; Pietsch T; Andreiuolo F; Driever PH; Korshunov A; Hiddingh L; Worst BC; Sturm D; Zuckermann M; Witt O; Bloom T; Mitchell C; Miele E; Colafati GS; Diomedi-Camassei F; Bailey S; Moore AS; Hassall TEG; Lowis SP; Tsoli M; Cowley MJ; Ziegler DS; Karajannis MA; Aquilina K; Hargrave DR; Carceller F; Marshall LV, 2020, 'Infant high-grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes', Cancer Discovery, vol. 10, pp. 942 - 963, http://dx.doi.org/10.1158/2159-8290.CD-19-1030
    Journal articles | 2019
    Dr Maria Tsoli
    Rampersaud E; Ziegler DS; Iacobucci I; Payne-Turner D; Churchman ML; Schrader KA; Joseph V; Offit K; Tucker K; Sutton R; Warby M; Chenevix-Trench G; Huntsman DG; Tsoli M; Scott Mead R; Qu C; Leventaki V; Wu G; Mullighan CG, 2019, 'Germline deletion of ETV6 in familial acute lymphoblastic leukemia', Blood Advances, vol. 3, pp. 1039 - 1046, http://dx.doi.org/10.1182/bloodadvances.2018030635
    Journal articles | 2019
    Dr Maria Tsoli
    Franshaw L; Tsoli M; Byrne J; Mayoh C; Sivarajasingam S; Norris M; Marshall GM; Ziegler DS, 2019, 'Predictors of Success of Phase II Pediatric Oncology Clinical Trials', Oncologist, vol. 24, pp. e765 - e774, http://dx.doi.org/10.1634/theoncologist.2017-0666
    Journal articles | 2019
    Dr Maria Tsoli
    Tsoli M; Shen H; Mayoh C; Franshaw L; Ehteda A; Upton D; Carvalho D; Vinci M; Meel MH; van Vuurden D; Plessier A; Castel D; Drissi R; Farrell M; Cryan J; Crimmins D; Caird J; Pears J; Francis S; Ludlow LEA; Carai A; Mastronuzzi A; Liu B; Hansford J; Gottardo NG; Hassall T; Kirby M; Fouladi M; Hawkins C; Monje M; Grill J; Jones C; Hulleman E; Ziegler DS, 2019, 'Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma (Journal of Neuro-Oncology, (2019), 141, 2, (253-263), 10.1007/s11060-018-03038-2)', Journal of Neuro-Oncology, vol. 141, pp. 265, http://dx.doi.org/10.1007/s11060-018-03060-4
    Journal articles | 2019
    Dr Maria Tsoli
    Tsoli M; Shen H; Mayoh C; Franshaw L; Ehteda A; Upton D; Carvalho D; Vinci M; Meel MH; van Vuurden D; Plessier A; Castel D; Drissi R; Farrell M; Cryan J; Crimmins D; Caird J; Pears J; Francis S; Ludlow LEA; Carai A; Mastronuzzi A; Liu B; Hansford J; Gottardo N; Hassall T; Kirby M; Fouladi M; Hawkins C; Monje M; Grill J; Jones C; Hulleman E; Ziegler DS, 2019, 'International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma', Journal of Neuro-Oncology, vol. 141, pp. 253 - 263, http://dx.doi.org/10.1007/s11060-018-03038-2
    Journal articles | 2019
    Dr Maria Tsoli
    Franshaw L; Tsoli M; Lau LMS; Ziegler DS, 2019, 'Translating palbociclib to the clinic for DIPG - What is truly achievable?', EBioMedicine, vol. 45, pp. 22, http://dx.doi.org/10.1016/j.ebiom.2019.06.024
    Journal articles | 2018
    Dr Maria Tsoli
    Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin JX; Gayevskiy V; Kumar A; Kaplan W; Ekert PG; Saletta F; Franshaw L; Liu J; Gifford A; Weber MA; Rodriguez M; Cohn RJ; Arndt G; Tyrrell V; Haber M; Trahair T; Marshall GM; McDonald K; Cowley MJ; Ziegler DS, 2018, 'Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer', Cancer Biology and Therapy, vol. 19, pp. 1078 - 1087, http://dx.doi.org/10.1080/15384047.2018.1491498
    Journal articles | 2018
    Dr Maria Tsoli
    Ziegler DS; Wong M; Mayoh C; Kumar A; Tsoli M; Mould E; Tyrrell V; Khuong-Quang DA; Pinese M; Gayevskiy V; Cohn RJ; Lau LMS; Reynolds M; Cox MC; Gifford A; Rodriguez M; Cowley MJ; Ekert PG; Marshall GM; Haber M, 2018, 'Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma', British Journal of Cancer, vol. 119, pp. 693 - 696, http://dx.doi.org/10.1038/s41416-018-0251-2
    Journal articles | 2018
    Dr Maria Tsoli
    Tsoli M; Liu J; Franshaw L; Shen H; Cheng C; Jung MS; Joshi S; Ehteda A; Khan A; Montero-Carcabosso A; Dilda PJ; Hogg P; Ziegler DS, 2018, 'Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma', Oncotarget, vol. 9, pp. 7541 - 7556, http://dx.doi.org/10.18632/oncotarget.24045
    Journal articles | 2017
    Dr Maria Tsoli
    Hennika T; Hu G; Olaciregui NG; Barton KL; Ehteda A; Chitranjan A; Chang C; Gifford AJ; Tsoli M; Ziegler DS; Carcaboso AM; Becher OJ, 2017, 'Pre-clinical study of panobinostat in xenograft and genetically engineered murine diffuse intrinsic pontine glioma models', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0169485
    Journal articles | 2017
    Dr Maria Tsoli
    Lapin DH; Tsoli M; Ziegler DS, 2017, 'Genomic insights into diffuse intrinsic pontine glioma', Frontiers in Oncology, vol. 7, http://dx.doi.org/10.3389/fonc.2017.00057
    Journal articles | 2016
    Dr Maria Tsoli
    Tsoli M; Swarbrick MM; Robertson GR, 2016, 'Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia', Seminars in Cell and Developmental Biology, vol. 54, pp. 68 - 81, http://dx.doi.org/10.1016/j.semcdb.2015.10.039
    Journal articles | 2014
    Dr Maria Tsoli
    Vanniasinghe A, 2014, 'Depletion of White Adipose Tissue in Cancer Cachexia Syndrome Is Associated with Inflammatory Signaling and Disrupted Circadian Regulation', PLoS One, vol. 9, http://dx.doi.org/10.1371/journal.pone.0092966
    Journal articles | 2014
    Dr Maria Tsoli
    Petruzzelli M; Schweiger M; Schreiber R; Campos-Olivas R; Tsoli M; Allen J; Swarbrick M; Rose-John S; Rincon M; Robertson G; Zechner R; Wagner EF, 2014, 'A switch from white to brown fat increases energy expenditure in cancer-associated cachexia', Cell Metab, vol. 20, pp. 433 - 447, http://dx.doi.org/10.1016/j.cmet.2014.06.011
    Journal articles | 2012
    Dr Maria Tsoli
    Keating J; Tsoli M; Hallahan AR; Ingram WJ; Haber M; Ziegler DS, 2012, 'Targeting the inhibitor of apoptosis proteins as a novel therapeutic strategy in medulloblastoma', Molecular Cancer Therapeutics, vol. 11, pp. 2654 - 2663, http://dx.doi.org/10.1158/1535-7163.MCT-12-0352
    Journal articles | 2012
    Dr Maria Tsoli
    Tsoli M; Robertson GR, 2012, 'Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem', Trends in Endocrinology and Metabolism, vol. 24, pp. 174 - 183, http://dx.doi.org/10.1016/j.tem.2012.10.006
    Journal articles | 2012
    Dr Maria Tsoli
    Tsoli M; Moore MM; Burg DW; Painter AB; Taylor R; Lockie SH; Turner N; Warren A; Cooney GJ; Oldfield BJ; Clark SJ; Robertson GR, 2012, 'Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice', Cancer Research, vol. 72, pp. 4372 - 4382, http://dx.doi.org/10.1158/0008-5472.CAN-11-3536
    Journal articles | 2012
    Dr Maria Tsoli
    Shum A; Theodore M; Taylor R; Painter AB; Moore MM; Tsoli M; Tan TC; Clarke SJ; Robertson GR; Polly P, 2012, 'Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting', Aging, vol. 4, pp. 133 - 143, http://dx.doi.org/10.18632/aging.100436
    Journal articles | 2011
    Dr Maria Tsoli
    Lee A; Chick JM; Kolarich D; Haynes PA; Robertson GR; Tsoli M; Jankova L; Clarke SJ; Packer NH; Baker MS, 2011, 'Liver membrane proteome glycosylation changes in mice bearing an extra-hepatic tumor.', Molecular & cellular proteomics : MCP, vol. 10
    Journal articles | 2010
    Dr Maria Tsoli
    Matic M; Corradin AP; Tsoli M; Clarke SJ; Polly P; Robertson GR, 2010, 'The alternatively spliced murine pregnane X receptor isoform, mPXR 171–211 exhibits a repressive action', International Journal of Biochemistry and Cell Biology, vol. 42, pp. 672 - 682, http://dx.doi.org/10.1016/j.biocel.2010.01.001
    Journal articles | 2007
    Dr Maria Tsoli
    Matic M; Mahns A; Tsoli M; Corradin AP; Polly P; Robertson GR, 2007, 'Pregnane X Receptor: Promiscuous regulator of detoxification pathways', International Journal of Biochemistry and Cell Biology, vol. 39, pp. 478 - 483, http://dx.doi.org/10.1016/j.biocel.2006.08.017
    Journal articles | 2005
    Dr Maria Tsoli
    Tsoli M; Kuhn H; Brandau W; Esche H; Schmid G, 2005, 'Cellular uptake and toxicity of Au55 clusters', Small, vol. 1, pp. 841 - 844, http://dx.doi.org/10.1002/smll.200500104
    Journal articles | 2004
    Dr Maria Tsoli
    Tsoli M; Kuhn H; Schmid G, 2004, 'Molecular docking simulations of the interactions between DNA molecules and a gold cluster', Materials Research Society Symposium Proceedings, vol. EXS, pp. 417 - 423
    Journal articles | 2003
    Dr Maria Tsoli
    Liu Y; Meyer-Zaika W; Franzka S; Schmid G; Tsoli M; Kuhn H, 2003, 'Gold-cluster degradation by the transition of B-DNA into A-DNA and the formation of nanowires', Angewandte Chemie - International Edition, vol. 42, pp. 2853 - 2857, http://dx.doi.org/10.1002/anie.200250235
    Journal articles | 2003
    Dr Maria Tsoli
    Liu Y; Meyer-Zaika W; Franzka S; Schmid G; Tsoli M; Kuhn H, 2003, 'Goldcluster-Abbau durch den Übergang von B-DNA in A-DNA und Bildung von Nanodrähten', Angewandte Chemie, vol. 115, pp. 2959 - 2963, http://dx.doi.org/10.1002/ange.200250235
  • Conference Abstracts | 2020
    Dr Maria Tsoli
    Ehteda A; Franshaw L; Liu J; Joshi S; Simon S; Pang CNI; Giorgi F; Pandher R; Ung C; Tolhurst O; Mayoh C; Khan A; Hayden E; Gopalakrishnan A; Trebilcock P; Upton D; Lehmann R; George S; Vittorio O; Tsoli M; Gurova K; Gudkov AG; Norris MD; Haber M; Ziegler DS, 2020, 'DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii292 - iii292, http://dx.doi.org/10.1093/neuonc/noaa222.076
    Conference Abstracts | 2020
    Dr Maria Tsoli
    Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Nath C; Reynolds P; Tsoli M; Ziegler D, 2020, 'DIPG-07. HIGH THROUGHPUT DRUG SCREENING IDENTIFIES POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii288 - iii288, http://dx.doi.org/10.1093/neuonc/noaa222.058
    Conference Abstracts | 2020
    Dr Maria Tsoli
    Khan A; Gamble L; Upton D; Yu D; Ehteda A; Pandher R; Mayoh C; Burns M; Norris M; Haber M; Tsoli M; Ziegler D, 2020, 'DIPG-15. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii289 - iii290, http://dx.doi.org/10.1093/neuonc/noaa222.065
    Conference Abstracts | 2020
    Dr Maria Tsoli
    Ung C; Tsoli M; Liu J; Cassano D; Upton D; Ehteda A; Mansfield F; Failes T; Kavallaris M; Arndt G; Vittorio O; Voliani V; Cirilo G; Ziegler DS, 2020, 'DDEL-12. NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii286 - iii286, http://dx.doi.org/10.1093/neuonc/noaa222.047
    Conference Abstracts | 2020
    Dr Maria Tsoli
    Franshaw L; Hayden E; Joshi S; Liu J; Ehteda A; Pang CNI; Tsoli M; Ziegler DS, 2020, 'DIPG-14. TARGETING POLO-LIKE KINASE 1 IN COMBINATION WITH KEY ONCOGENIC DRIVERS IN DIPG: FROM SINGLE AGENT TO COMBINATION STRATEGIES', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii289 - iii289, http://dx.doi.org/10.1093/neuonc/noaa222.064
    Conference Abstracts | 2020
    Dr Maria Tsoli
    Khan A; Gamble L; Pandher R; Burns MR; Mussai F; Norris M; Haber M; Tsoli M; Ziegler DS, 2020, 'DIPG-16. COMBINATION OF ARGININE DEPLETION AND POLYAMINE INHIBITION AS AN ANTICANCER STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii290 - iii290, http://dx.doi.org/10.1093/neuonc/noaa222.066
    Conference Abstracts | 2020
    Dr Maria Tsoli
    Duchatel RJ; Mannan A; Jackson ER; Staudt D; Skerrett-Byrne DA; Jamaluddin MFB; Woldu AS; Douglas A; Hulleman E; Carcaboso AM; Monje M; Alvaro F; Tsoli M; Ziegler DS; Dun MD, 2020, 'DIPG-29. PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE (PI3K) INHIBITION DRIVES PROTEIN KINASE C ACTIVATION (PKC) IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii292 - iii293, http://dx.doi.org/10.1093/neuonc/noaa222.078
    Conference Abstracts | 2019
    Dr Maria Tsoli
    Duchatel R; Jackson E; Patabendige A; Cain J; Tsoli M; Monje M; Alvaro F; Ziegler D; Dun M, 2019, 'DIPG-03. TARGETING PI3K USING THE BLOOD BRAIN BARRIER PENETRABLE INHIBITOR, GDC-0084, FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 21, pp. ii68 - ii68, http://dx.doi.org/10.1093/neuonc/noz036.024
    Conference Abstracts | 2018
    Dr Maria Tsoli
    Ziegler D; Tsoli M; Tyrell V; Cohn R; Lau L; Cox M; Cowley M; Ekert P; Marshall G; Haber M, 2018, 'EAPH-09. POTENT CLINICAL AND RADIOLOGICAL RESPONSE TO LAROTRECTINIB IN FIRST CASE OF TRK FUSION HIGH GRADE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 20, pp. i67 - i67, http://dx.doi.org/10.1093/neuonc/noy059.178
    Conference Abstracts | 2018
    Dr Maria Tsoli
    Khan A; Tsoli M; Yu D; Joshi S; Gamble L; Franshaw L; Haber M; Ziegler DS, 2018, 'Abstract 4800: Targeting the polyamine pathway as a novel therapeutic treatment against diffuse intrinsic pontine glioma', in Experimental and Molecular Therapeutics, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL, http://dx.doi.org/10.1158/1538-7445.am2018-4800
    Conference Abstracts | 2018
    Dr Maria Tsoli
    Khan A; Gamble L; Yu D; Joshi S; Franshaw L; Burns M; Norris M; Haber M; Tsoli M; Ziegler D, 2018, 'DIPG-01. TARGETING THE POLYAMINE PATHWAY AS A NOVEL THERAPEUTIC TREATMENT AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 20, pp. i49 - i49, http://dx.doi.org/10.1093/neuonc/noy059.095
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Lau L; Byrne J; Ekert PG; Failes T; Fellowes A; Fletcher J; Gifford A; Haber M; Kumar A; Lock R; Marshall G; McCowage GB; Mould E; Norris M; Trahair T; Tsoli M; Tyrrell V; Wadham C; Xie J; Ziegler DS, 2017, 'Pilot study of a comprehensive precision medicine platform for children with high-risk cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, Vol. 35, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, 02 June 2017 - 06 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.10539
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Tsoli M; Lapin D; Franshaw L; Shen H; Liu J; Ziegler D, 2017, 'DIPG-04. COMBINED TARGETING OF CALCIUM SIGNALLING AND RTK/PI3K PATHWAY IS A NOVEL THERAPEUTIC APPROACH AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 19, pp. iv5 - iv5, http://dx.doi.org/10.1093/neuonc/nox083.019
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Tsoli M; Yeung N; Valvi S; Joshi S; Franshaw L; Shen H; Liu J; Ziegler D, 2017, 'DIPG-05. COMBINATION OF SYNTHETIC RETINOID FENRETINIDE WITH RECEPTOR TYROSINE KINASE INHIBITOR PONATINIB AS A POTENTIAL NEW APPROACH AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 19, pp. iv5 - iv6, http://dx.doi.org/10.1093/neuonc/nox083.020
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Shen H; Chang C; Joshi S; Liu J; Tsoli M; Hau E; Ziegler D, 2017, 'DIPG-02. RADIOSENSITIVITY OF DIPG CELLS IS ENHANCED BY TARGETING GLUCOSE METABOLISM IN VITRO AND IN VIVO', in Neuro-Oncology, Oxford University Press (OUP), Vol. 19, pp. iv5 - iv5, http://dx.doi.org/10.1093/neuonc/nox083.017
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Franshaw L; Chang C; Joshi S; Ehteda A; Tsoli M; Ziegler D, 2017, 'DIPG-07. INDUCING DNA LETHALITY THROUGH POLO-LIKE KINASE 1 INHIBITION: A NOVEL THERAPEUTIC APPROACH IN DIPG', in Neuro-Oncology, Oxford University Press (OUP), Vol. 19, pp. iv6 - iv6, http://dx.doi.org/10.1093/neuonc/nox083.022
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Ehteda A; Kankean A; Chitranjan A; Tsoli M; Liu J; Shen H; Franshaw L; Joshi S; Chang C; Ager E; Ziegler DS, 2017, 'DIPG-09. TRX-E-009-1 IS A NOVEL AND A POTENT THERAPEUTIC AGENT FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in Neuro-Oncology, Oxford University Press (OUP), Vol. 19, pp. iv6 - iv6, http://dx.doi.org/10.1093/neuonc/nox083.024
    Conference Abstracts | 2017
    Dr Maria Tsoli
    Franshaw L; Tsoli M; Byrne J; Sivarajasingam S; Norris M; Marshall G; Ziegler D, 2017, 'TRTH-05. PREDICTORS OF SUCCESS OF PHASE 2 PAEDIATRIC ONCOLOGY CLINICAL TRIALS', in Neuro-Oncology, Oxford University Press (OUP), Vol. 19, pp. iv52 - iv52, http://dx.doi.org/10.1093/neuonc/nox083.217
    Conference Abstracts | 2016
    Dr Maria Tsoli
    Tsoli M; Chang C; Shen H; Liu J; Chintranjan A; Franshaw L; Dilda P; Carcaboso AM; Hogg P; Ziegler D, 2016, 'HG-19COMBINED TARGETING OF MITOCHONDRIAL FUNCTION AND mTOR IS A POTENT NOVEL THERAPEUTIC APPROACH FOR DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 18, pp. iii51.3 - iii51, http://dx.doi.org/10.1093/neuonc/now073.16
    Conference Abstracts | 2016
    Dr Maria Tsoli
    Shen H; Tsoli M; Chang C; Chitranjan A; Liu J; Hau E; Kankean A; Ehteda A; Franshaw L; Valvi S; Ziegler D, 2016, 'HG-04DICHLOROACETATE AND METFORMIN COMBINE TO MODULATE GLUCOSE METABOLISM AND POTENTLY SENSITISE DIPG CELLS TO RADIATION THERAPY', in Neuro-Oncology, Oxford University Press (OUP), Vol. 18, pp. iii48.3 - iii48, http://dx.doi.org/10.1093/neuonc/now073.03
    Conference Abstracts | 2016
    Dr Maria Tsoli
    Valvi S; Tsoli M; Chitranjan A; Shen H; Chang C; Kankean A; Ehteda A; Franshaw L; Liu J; Ziegler D, 2016, 'HG-25FENRETINIDE TARGETS THE RTK-PI3K PATHWAY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 18, pp. iii52.5 - iii53, http://dx.doi.org/10.1093/neuonc/now073.22
    Conference Abstracts | 2016
    Dr Maria Tsoli
    Ehteda A; Tsoli M; Chitranjan A; Chang C; Simon S; Kankean A; Shen H; Liu J; Haber M; Gudkov A; Ziegler D, 2016, 'HG-20COMBINATION OF EPIGENETIC MODIFIERS CBL0137 AND PANOBINOSTAT IS HIGHLY POTENT IN VITRO AND IN VIVO FOR DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 18, pp. iii51.4 - iii51, http://dx.doi.org/10.1093/neuonc/now073.17
    Conference Abstracts | 2015
    Dr Maria Tsoli
    Kankean A; Ehteda A; Chitranjan A; Tsoli M; Ager E; Ziegler D, 2015, 'BT-09 * TRILEXIUM INHIBITS THE EXPRESSION OF t-NOX AND IS A NOVEL, POTENTIALLY POTENT THERAPY FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in Neuro-Oncology, Oxford University Press (OUP), Vol. 17, pp. iii5 - iii5, http://dx.doi.org/10.1093/neuonc/nov061.19
    Conference Abstracts | 2015
    Dr Maria Tsoli
    Kankean A; Tsoli M; Tsang J; Chitranjan A; Maleki S; McDonald K; Ziegler D, 2015, 'HG-16 * THE ANTI-APOPTOTIC PROTEIN ARC IS OVER-EXPRESSED IN MALIGNANT GLIOMA AND CORRELATES WITH PATIENT OUTCOME', in Neuro-Oncology, Oxford University Press (OUP), Vol. 17, pp. iii14 - iii14, http://dx.doi.org/10.1093/neuonc/nov061.53
    Conference Abstracts | 2015
    Dr Maria Tsoli
    Haber M; Murray J; Gamble L; Carnegie-Clark A; Webber H; Ruhle M; Henderson MJ; Middlemass S; Carter D; Tsoli M; Ehteda A; Simon S; Oberthuer A; Fischer M; Gurova K; Burkhart C; Purmal A; Lock RB; Ziegler D; Marshall GM; Gudkov AV; Norris MD, 2015, 'The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Philadelphia, PA, Vol. 75, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-1611
    Conference Abstracts | 2013
    Dr Maria Tsoli
    Mitic G; Tsoli M; Ziegler DS; Kavallaris M, 2013, 'beta III-tubulin in glioblastoma: An emerging multifactorial survival factor role in chemotherapy response and tumor formation.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, Vol. 73, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-3431

Awards

2020: Senior Lecturer (Conjoint) 

2019: Levi Wheeler Fellow

2016: Organisation of Hellene and Hellene-Cypriot Women of Australia

2013: Children's Cancer Institute Quarterly Staff award

 

Grants

Current Funding:

  • 2019-2021: Cure Brain Cancer Foundation Innovation Grant: Tsoli M (CIA), New therapeutic strategies for DIPG-understanding the role of super BBB in brainstem and ways to overcome it. 
  • 2019-2020: DIPG Collaborative: Tsoli M (CIA), Developing new epigenetic combination treatments against DIPG. 
  • 2019-2022: Cancer Australia: Tsoli M (CIC), Targeting Polo-like kinase 1 as a novel therapeutic opportunity for Diffuse Intrinsic Pontine Gliomas. 
  • 2018-2019: DIPG Collaborative: Tsoli M & Ziegler DS, Polyamine pathway metabolism as a novel therapeutic option for DIPG. 
  • 2017 – 2020 Cancer Australia: Tsoli M (CID), Synthetic retinoid therapy for DIPG. 

Previous Funding:

  • 2017-2018: Tour De Cure Pioneering grant: Tsoli M (CIA), A trojan horse strategy against DIPG. 
  • 2015-2016 The Cure Starts Now: Tsoli M & Ziegler DS, Fenretinide, a novel agent targeting RTK/PI3K/AKT network for the treatment of Diffuse Intrinsic Pontine Glioma, 
  • 2014-2015 The Cure Starts Now: Tsoli M & Ziegler DS, Facilitates Chromatin Transcription Complex (FACT): A novel therapeutic target against Diffuse Intrinsic Pontine Glioma, 
  • 2014-2015 Cure Brain Cancer Foundation: Tsoli M & Ziegler DS, Novel targeted chemotherapeutic agents against Diffuse Intrinsic Pontine Gliomas (DIPG), 

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