Professor Mark Tanaka

I am a mathematical and computational biologist at the University of New South Wales (UNSW) in the School of Biotechnology and Biomolecular Sciences (BABS). At UNSW I am also a member of the Evolution & Ecology Research Centre (E&ERC). I received my BSc(Hons) in genetics from the University of Sydney and my PhD in mathematical biology from Stanford University. My postdoctoral work at Emory University was in the area of microbial evolution.

A major component of my research programme concerns understanding how microbes including pathogens evolve. My research has considered topics such as mutation rates in pathogens and how they evolve; how antimicrobial resistance arises and the consequences of the fitness cost of resistance; the life-cycle of viruses; features of bacterial genomes such as mobile genes and gene clusters; and how microbes alter their environments and thus their own evolutionary trajectory. Another component of my research concerns analysis of genetic data from pathogen isolates collected in molecular epidemiology studies. My research group develops mathematical models which we use to make inferences from genetic and genomic data. I am also interested in human cultural evolution and modelling the interaction between behaviour and disease/health.

For more information about us please visit our lab website.

Professional service roles and affiliations

PLoS Computational Biology, Associate Editor
Theoretical Population Biology, Associate Editor
Genetics Society of AustralAsia, Society for Mathematical Biology, Member
Acting Head of School, BABS, 2018-2019
Deputy Head of School (Research Director), BABS, 2016-2018.

E-mail

m.tanaka@unsw.edu.au

Location

Room: 2111 Biological Sciences E26

Publications
Awards
Grants
Media
Teaching and Supervision

Publications

Book Chapters | 2018

Rodrigues G; Francis A; Sisson S; Tanaka M, 2018, 'Inferences on the acquisition of multidrug resistance in Mycobacterium tuberculosis using molecular epidemiological data', in Sisson S; Fan Y; Beaumont M (ed.), Approximate Bayesian Computation Likelihood-Free Methods for Complex Models, Chapman & Hall

Book Chapters | 2017

Pečerska J; Wood J; Tanaka MM; Stadler T, 2017, 'Mathematical models for the epidemiology and evolution of mycobacterium tuberculosis', in Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control, Springer, pp. 281 - 307, http://dx.doi.org/10.1007/978-3-319-64371-7_15
Journal articles | 2021

Payne M; Octavia S; Luu LDW; Sotomayor-Castillo C; Wang Q; Tay ACY; Sintchenko V; Tanaka MM; Lan R, 2021, 'Enhancing genomics-based outbreak detection of endemic salmonella enterica serovar typhimurium using dynamic thresholds', Microbial Genomics, vol. 7, http://dx.doi.org/10.1099/MGEN.0.000310

Journal articles | 2021

Luo L; Payne M; Kaur S; Hu D; Cheney L; Octavia S; Wang Q; Tanaka MM; Sintchenko V; Lan R, 2021, 'Elucidation of global and national genomic epidemiology of salmonella enterica serovar enteritidis through multilevel genome typing', Microbial Genomics, vol. 7, http://dx.doi.org/10.1099/MGEN.0.000605

Journal articles | 2021

Xiong X; Loo SL; Zhang L; Tanaka MM, 2021, 'Modelling the effect of birth and feeding modes on the development of human gut microbiota', Proceedings of the Royal Society B: Biological Sciences, vol. 288, pp. 20201810, http://dx.doi.org/10.1098/rspb.2020.1810

Journal articles | 2020

Payne M; Kaur S; Wang Q; Hennessy D; Luo L; Octavia S; Tanaka MM; Sintchenko V; Lan R, 2020, 'Multilevel genome typing: Genomics-guided scalable resolution typing of microbial pathogens', Eurosurveillance, vol. 25, http://dx.doi.org/10.2807/1560-7917.ES.2020.25.20.1900519

Journal articles | 2020

Zhang E; Thibaut LM; Terauds A; Raven M; Tanaka MM; Van Dorst J; Wong SY; Crane S; Ferrari BC, 2020, 'Lifting the veil on arid-to-hyperarid Antarctic soil microbiomes: A tale of two oases', Microbiome, vol. 8, pp. 37, http://dx.doi.org/10.1186/s40168-020-00809-w

Journal articles | 2020

Lai YW; Ridone P; Peralta G; Tanaka MM; Baker MAB, 2020, 'Evolution of the stator elements of rotary prokaryote motors', Journal of Bacteriology, vol. 202, http://dx.doi.org/10.1128/JB.00557-19

Journal articles | 2020

Tanaka MM; Godfrey-Smith P; Kerr B, 2020, 'The dual landscape model of adaptation and niche construction', Philosophy of Science, vol. 87, pp. 478 - 498, http://dx.doi.org/10.1086/708692

Journal articles | 2020

Aandahl RZ; Bhatia S; Vaudagnotto N; Street AG; Francis AR; Tanaka MM, 2020, 'MERCAT: Visualising molecular epidemiology data combining genetic markers and drug resistance profiles', Infection, Genetics and Evolution, vol. 77, pp. 104043, http://dx.doi.org/10.1016/j.meegid.2019.104043

Journal articles | 2020

Loo SL; Ong A; Kyaw W; Thibaut LM; Lan R; Tanaka MM, 2020, 'Nonsynonymous Polymorphism Counts in Bacterial Genomes: a Comparative Examination', Applied and Environmental Microbiology, vol. 87, pp. 1 - 16, http://dx.doi.org/10.1128/AEM.02002-20

Journal articles | 2020

Jayasundara D; Lee E; Octavia S; Lan R; Tanaka MM; Wood JG, 2020, 'Emergence of pertactin-deficient pertussis strains in Australia can be explained by models of vaccine escape', Epidemics, vol. 31, pp. 100388, http://dx.doi.org/10.1016/j.epidem.2020.100388

Journal articles | 2019

Russo AG; Kelly AG; Tuipulotu DE; Tanaka MM; White PA, 2019, 'Novel insights into endogenous RNA viral elements in Ixodes scapularis and other arbovirus vector genomes', Virus Evolution, vol. 5, http://dx.doi.org/10.1093/ve/vez010

Journal articles | 2018

Chisholm RH; Connelly BD; Kerr B; Tanaka MM, 2018, 'The role of pleiotropy in the evolutionary maintenance of positive niche construction', American Naturalist, vol. 192, pp. 35 - 48, http://dx.doi.org/10.1086/697471

Journal articles | 2018

Liu F; Ma R; Tay CYA; Octavia S; Lan R; Chung HKL; Riordan SM; Grimm MC; Leong RW; Tanaka MM; Connor S; Zhang L, 2018, 'Genomic analysis of oral Campylobacter concisus strains identified a potential bacterial molecular marker associated with active Crohn's disease', Emerging Microbes and Infections, vol. 7, http://dx.doi.org/10.1038/s41426-018-0065-6

Journal articles | 2017

Serdoz S; Egri-Nagy A; Sumner J; Holland BR; Jarvis PD; Tanaka MM; Francis AR, 2017, 'Maximum likelihood estimates of pairwise rearrangement distances', Journal of Theoretical Biology, vol. 423, pp. 31 - 40, http://dx.doi.org/10.1016/j.jtbi.2017.04.015

Journal articles | 2017

Fu S; Hiley L; Octavia S; Tanaka MM; Sintchenko V; Lan R, 2017, 'Comparative genomics of Australian and international isolates of Salmonella Typhimurium: Correlation of core genome evolution with CRISPR and prophage profiles', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-06079-1

Journal articles | 2017

Eden JS; Chisholm RH; Bull RA; White PA; Holmes EC; Tanaka MM, 2017, 'Persistent infections in immunocompromised hosts are rarely sources of new pathogen variants', Virus Evolution, vol. 3, http://dx.doi.org/10.1093/ve/vex018

Journal articles | 2017

Octavia S; Wang Q; Tanaka MM; Sintchenko V; Lan R, 2017, 'Genomic heterogeneity of Salmonella enterica serovar Typhimurium bacteriuria from chronic infection', Infection, Genetics and Evolution, vol. 51, pp. 17 - 20, http://dx.doi.org/10.1016/j.meegid.2017.03.004

Journal articles | 2016

Chisholm RH; Trauer JM; Curnoed D; Tanaka MM, 2016, 'Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. 9051 - 9056, http://dx.doi.org/10.1073/pnas.1603224113

Journal articles | 2016

Chisholm RH; Tanaka MM, 2016, 'The emergence of latent infection in the early evolution of Mycobacterium tuberculosis', Proceedings of the Royal Society B: Biological Sciences, vol. 283, http://dx.doi.org/10.1098/rspb.2016.0499

Journal articles | 2016

Mahendran V; Liu F; Riordan SM; Grimm MC; Tanaka MM; Zhang L, 2016, 'Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages', Gut Pathogens, vol. 8, http://dx.doi.org/10.1186/s13099-016-0101-9

Journal articles | 2016

Murray V; Chen JK; Tanaka MM, 2016, 'The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells', Molecular Biology Reports, vol. 43, pp. 639 - 651, http://dx.doi.org/10.1007/s11033-016-3998-7

Journal articles | 2016

Fu S; Octavia S; Wang Q; Tanaka MM; Tay CY; Sintchenko V; Lan R, 2016, 'Evolution of variable number tandem repeats and its relationship with genomic diversity in Salmonella typhimurium', Frontiers in Microbiology, vol. 7, http://dx.doi.org/10.3389/fmicb.2016.02002

Journal articles | 2016

Chan CHS; Sanders LP; Tanaka MM, 2016, 'Modelling the role of immunity in reversion of viral antigenic sites', Journal of Theoretical Biology, vol. 392, pp. 23 - 34, http://dx.doi.org/10.1016/j.jtbi.2015.12.008

Journal articles | 2015

Wu Y; Aandahl RZ; Tanaka MM, 2015, 'Dynamics of bacterial insertion sequences: Can transposition bursts help the elements persist? Theories and models', BMC Evolutionary Biology, vol. 15, http://dx.doi.org/10.1186/s12862-015-0560-5

Journal articles | 2015

Peck KM; Chan CHS; Tanaka M, 2015, 'Connecting within-host dynamics to the rate of viral molecular evolution', Virus Evolution, vol. 1, pp. vev013 - vev013, http://dx.doi.org/10.1093/ve/vev013

Journal articles | 2015

Octavia S; Wang Q; Tanaka MM; Kaur S; Sintchenko V; Lan R, 2015, 'Delineating community outbreaks of Salmonella enterica serovar typhimurium by use of whole-genome sequencing: Insights into genomic variability within an outbreak', Journal of Clinical Microbiology, vol. 53, pp. 1063 - 1071, http://dx.doi.org/10.1128/JCM.03235-14

Journal articles | 2015

Fu S; Octavia S; Tanaka MM; Sintchenko V; Lan R, 2015, 'Defining the core genome of salmonella enterica serovar typhimurium for genomic surveillance and epidemiological typing', Journal of Clinical Microbiology, vol. 53, pp. 2530 - 2538, http://dx.doi.org/10.1128/JCM.03407-14

Journal articles | 2015

Octavia S; Wang Q; Tanaka MM; Sintchenko V; Lan R, 2015, 'Genomic variability of serial human isolates of salmonella enterica serovar typhimurium associated with prolonged carriage', Journal of Clinical Microbiology, vol. 53, pp. 3507 - 3514, http://dx.doi.org/10.1128/JCM.01733-15

Journal articles | 2014

Tanaka MM; Althouse BM; Bergstrom CT, 2014, 'Timing of antimicrobial use influences the evolution of antimicrobial resistance during disease epidemics', Evolution, Medicine and Public Health, vol. 2014, pp. 150 - 161, http://dx.doi.org/10.1093/emph/eou027

Journal articles | 2014

Wu Y; Saddler CA; Valckenborgh F; Tanaka MM, 2014, 'Dynamics of evolutionary rescue in changing environments and the emergence of antibiotic resistance', Journal of Theoretical Biology, vol. 340, pp. 222 - 231, http://dx.doi.org/10.1016/j.jtbi.2013.09.026

Journal articles | 2014

Egri-Nagy A; Gebhardt V; Tanaka MM; Francis AR, 2014, 'Group-theoretic models of the inversion process in bacterial genomes', Journal of Mathematical Biology, vol. 69, pp. 243 - 265, http://dx.doi.org/10.1007/s00285-013-0702-6

Journal articles | 2014

Aandahl RZ; Stadler T; Sisson SA; Tanaka MM, 2014, 'Exact vs. approximate computation: Reconciling different estimates of Mycobacterium tuberculosis epidemiological parameters', Genetics, vol. 196, pp. 1227 - 1230, http://dx.doi.org/10.1534/genetics.113.158808

Journal articles | 2014

Eden JS; Hewitt J; Lim KL; Boni MF; Merif J; Greening G; Ratcliff RM; Holmes EC; Tanaka MM; Rawlinson WD; White PA, 2014, 'The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012', Virology, vol. 450-451, pp. 106 - 113, http://dx.doi.org/10.1016/j.virol.2013.12.005

Journal articles | 2014

Hamblin SR; White PA; Tanaka MM, 2014, 'Viral niche construction alters hosts and ecosystems at multiple scales', Trends in Ecology and Evolution, vol. 29, pp. 594 - 599, http://dx.doi.org/10.1016/j.tree.2014.08.005

Journal articles | 2013

Regoes RR; Hamblin S; Tanaka M, 2013, 'Viral mutation rates: Modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed', Proceedings of the Royal Society of London Series B - Biological Sciences, vol. 280, pp. 1 - 9, http://dx.doi.org/10.1098/rspb.2012.2047

Journal articles | 2013

Eden J-S; Tanaka M; Boni MF; Rawlinson WD; White PA, 2013, 'Recombination within the pandemic norovirus GII.4 lineage', Journal of Virology, vol. 87, pp. 6270 - 6282, http://dx.doi.org/10.1128/JVI.03464-12

Journal articles | 2013

Chan CHS; Hamblin S; Tanaka MM, 2013, 'The effects of linkage on comparative estimators of selection', BMC Evolutionary Biology, vol. 13, http://dx.doi.org/10.1186/1471-2148-13-244

Journal articles | 2013

Hamblin S; Tanaka MM, 2013, 'Behavioural manipulation of insect hosts by Baculoviridae as a process of niche construction', BMC Evolutionary Biology, vol. 13, http://dx.doi.org/10.1186/1471-2148-13-170

Journal articles | 2013

Saddler CA; Wu Y; Valckenborgh F; Tanaka MM, 2013, 'Epidemiological control of drug resistance and compensatory mutation under resistance testing and second-line therapy', Epidemics, vol. 5, pp. 164 - 173, http://dx.doi.org/10.1016/j.epidem.2013.08.002

Journal articles | 2012

Reyes JF; Chan C; Tanaka M, 2012, 'Impact of homoplasy on variable numbers of tandem repeats and spoligotypes in Mycobacterium tuberculosis', Infection Genetics and Evolution, vol. 12, pp. 811 - 818, http://dx.doi.org/10.1016/j.meegid.2011.05.018

Journal articles | 2012

Kidd M; Chen Z; Wang Y; Jackson KJ; Zhang L; Boyd SD; Fire AZ; Tanaka M; Gaeta BA; Collins AM, 2012, 'The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements', The Journal Of Immunology, vol. 188, pp. 1333 - 1340, http://dx.doi.org/10.4049/jimmunol.1102097

Journal articles | 2012

Aandahl R; Reyes JF; Sisson SA; Tanaka M, 2012, 'A model-based Bayesian estimation of the rate of evolution of VNTR loci in Mycobacterium tuberculosis', PLoS Computational Biology, vol. 8, pp. e1002573, http://dx.doi.org/10.1371/journal.pcbi.1002573

Journal articles | 2012

Francis AR; Tanaka M, 2012, 'Evolution of variation in presence and absence of genes in bacterial pathways', BMC Evolutionary Biology, vol. 12, pp. 1 - 11, http://dx.doi.org/10.1186/1471-2148-12-55

Journal articles | 2011

Tanaka M; Valckenborgh F, 2011, 'Escaping an evolutionary lobster trap: Drug resistance and compensatory mutation in a fluctuating environment', Evolution, vol. 65, pp. 1376 - 1387, http://dx.doi.org/10.1111/j.1558-5646.2011.01223.x

Journal articles | 2011

Octavia S; Ch''ng SL; Xia Q; Duong A; Tanaka M; Fukushima H; Lan R, 2011, 'Population structure and evolution of pathogenicity of Yersinia pseudotuberculosis', Applied and Environmental Microbiology, vol. 77, pp. 768 - 775, http://dx.doi.org/10.1128/AEM.01993-10

Journal articles | 2011

Tanaka M; Reyes JF, 2011, 'VNTR mutation in Mycobacterium tuberculosis: Lower rates for less variable loci', Infection Genetics and Evolution, vol. 11, pp. 1192 - 1192, http://dx.doi.org/10.1016/j.meegid.2011.03.013

Journal articles | 2011

Leshchyns'ka I; Tanaka M; Schachner M; Sytnyk V, 2011, 'Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions', The Journal of Biological Chemistry, vol. 286, pp. 23397 - 23406, http://dx.doi.org/10.1074/jbc.M111.252098

Journal articles | 2011

Tanaka M; Reyes JF, 2011, 'Mutation rate of VNTR loci in Mycobacterium tuberculosis: Response to Supply et al.', Infection Genetics and Evolution, vol. 11, pp. 1189 - 1190, http://dx.doi.org/10.1016/j.meegid.2011.01.014

Journal articles | 2010

Reyes JF; Tanaka M, 2010, 'Mutation rates of spoligotypes and variable numbers of tandem repeat loci in Mycobacterium tuberculosis', Infection Genetics and Evolution, vol. 10, pp. 1046 - 1051, http://dx.doi.org/10.1016/j.meegid.2010.06.016

Journal articles | 2010

Ballouz S; Lan R; Francis AR; Tanaka M, 2010, 'Conditions for the evolution of gene clusters in bacterial genomes.', PLoS Computational Biology, vol. 6, pp. e1000672 - e1000672, http://dx.doi.org/10.1371/journal.pcbi.1000672

Journal articles | 2010

Mclean A; Luciani F; Tanaka M, 2010, 'Trade-offs in resource allocation in the intracellular life-cycle of hepatitis C virus', Journal of Theoretical Biology, vol. 267, pp. 565 - 572, http://dx.doi.org/10.1016/j.jtbi.2010.09.031

Journal articles | 2009

Tanaka M; Kendal J; Laland K, 2009, 'From traditional medicine to witchcraft: Why medical treatments are not always efficacious', PLoS One, vol. 4, http://dx.doi.org/10.1371/journal.pone.0005192

Journal articles | 2009

Luciani F; Sisson SA; Jiang H; Francis AR; Tanaka M, 2009, 'The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 14711 - 14715, http://dx.doi.org/10.1073/pnas.0902437106

Journal articles | 2009

Sisson SA; Fan Y; Tanaka MM, 2009, 'Sequential Monte Carlo without likelihoods (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 6, (1760-1765) DOI:10.1073/pnas.0607208104)', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 16889, http://dx.doi.org/10.1073/pnas.0908847106

Journal articles | 2009

Tanaka M; Cristescu R; Cooper DW, 2009, 'Effective population size of koala populations under different population management regimes including contraception', Wildlife Research, vol. 36, pp. 601 - 609, http://dx.doi.org/10.1071/WR08160

Journal articles | 2009

Tanaka M; Sisson SA; King GC, 2009, 'High affinity extremes in combinatorial libraries and repertoires', Journal of Theoretical Biology, vol. 261, pp. 260 - 265, http://dx.doi.org/10.1016/j.jtbi.2009.07.041

Journal articles | 2008

Reyes JF; Francis AR; Tanaka M, 2008, 'Models of deletion for visualizing bacterial variation: an application to tuberculosis spoligotypes', BMC bioinformatics, vol. 9, pp. 496 - 511, http://dx.doi.org/10.1186/1471-2105-9-496

Journal articles | 2008

Tang C; Reyes JF; Luciani F; Francis AR; Tanaka M, 2008, 'spolTools: online utilities for analyzing spoligotypes of the Mycobacterium tuberculosis complex', Bioinformatics, vol. 24, pp. 2414 - 2415, http://dx.doi.org/10.1093/bioinformatics/btn434

Journal articles | 2008

Venturi V; Kedzierska K; Tanaka MM; Turner SJ; Doherty PC; Davenport MP, 2008, 'Method for assessing the similarity between subsets of the T cell receptor repertoire', Journal of Immunological Methods, vol. 329, pp. 67 - 80, http://dx.doi.org/10.1016/j.jim.2007.09.016

Journal articles | 2008

Luciani F; Francis AR; Tanaka M, 2008, 'Interpreting genotype cluster sizes of Mycobacterium tuberculosis isolates typed with IS6110 and spoligotyping', Infection Genetics and Evolution, vol. 8, pp. 182 - 190, http://dx.doi.org/10.1016/j.meegid.2007.12.004

Journal articles | 2007

Sisson SA; Fan Y; Tanaka M, 2007, 'Sequential Monte Carlo without likelihoods', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 1760 - 1765, http://dx.doi.org/10.1073/pnas.0607208104

Journal articles | 2007

Bull RA; Tanaka M; White PA, 2007, 'Norovirus recombination', Journal of General Virology, vol. 88, pp. 3347 - 3359, http://dx.doi.org/10.1099/vir.0.83321-0

Journal articles | 2007

Zaghloul L; Tang C; Chin H; Bek EJ; Lan R; Tanaka M, 2007, 'The distribution of insertion sequences in the genome of Shigella flexneri strain 2457T', FEMS Microbiology Letters, vol. 277, pp. 197 - 204, http://dx.doi.org/10.1111/j.1574-6968.2007.00957.x

Journal articles | 2006

Tanaka M; Francis AR, 2006, 'Detecting emerging strains of tuberculosis by using spoligotypes', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 15266 - 15271, http://dx.doi.org/10.1073/pnas.0603130103

Journal articles | 2006

Tanaka M; Francis AR; Luciani F; Sisson SA, 2006, 'Using approximate Bayesian computation to estimate tuberculosis transmission parameters from genotype data', Genetics, vol. 173, pp. 1511 - 1520, http://dx.doi.org/10.1534/genetics.106.055574

Journal articles | 2006

Tanaka M; Phong R; Francis AR, 2006, 'An evaluation of indices for quantifying tuberculosis transmission using genotypes of pathogen isolates', BMC Infectious Diseases, vol. 6, http://dx.doi.org/10.1186/1471-2334-6-92

Journal articles | 2005

Bull RA; Hansman G; Clancy LE; Tanaka M; Rawlinson WD; White PA, 2005, 'Norovirus recombination in ORF1/ORF2 overlap', Emerging Infectious Diseases, vol. 11, pp. 1079 - 1085, http://dx.doi.org/10.3201/eid1107.041273

Journal articles | 2005

Regoes R; Crotty S; Antia R; Tanaka M, 2005, 'Optimal replication of poliovirus within cells', American Naturalist, vol. 165, pp. 364 - 373, http://dx.doi.org/10.1086/428295

Journal articles | 2005

Tanaka M; Francis AR, 2005, 'Methods of quantifying and visualising outbreaks of tuberculosis using genotypic information', Infection Genetics and Evolution, vol. 5, pp. 35 - 43, http://dx.doi.org/10.1016/j.meegid.2004.06.001

Journal articles | 2004

Tanaka M; Rosenberg NA; Small P, 2004, 'The control of copy number of IS6110 in Mycobacterium tuberculosis', Molecular Biology and Evolution, vol. 21, pp. 2195 - 2201, http://dx.doi.org/10.1093/molbev/msh234

Journal articles | 2004

Tanaka M, 2004, 'Evidence for positive selection on Mycobacterium tuberculosis within patients', BMC Evolutionary Biology, vol. 4, pp. 31 - 31, http://dx.doi.org/10.1186/1471-2148-4-31

Journal articles | 2003

Tanaka M; Bergstrom CT; Levin B, 2003, 'The Evolution of Mutator Genes in Bacterial Populations: The Roles of Environmental Change and Timing', Genetics, vol. 164, pp. 843 - 854

Journal articles | 2003

Cotsapas C; Chan EK; Kirk MF; Tanaka M; Little PF, 2003, 'Genetic variation and the control of transcription', Cold Spring Harbor Symposia on Quantitative Biology, vol. 68, pp. 109 - 114, http://dx.doi.org/10.1101/sqb.2003.68.109

Journal articles | 2003

Rosenberg NA; Tsolaki AG; Tanaka M, 2003, 'Estimating change rates of genetic markers suing serial samples: applications to the transposon IS6110 in Mycobacterium tuberculosis', Theoretical Population Biology, vol. 63, pp. 347 - 363, http://dx.doi.org/10.1016/S0040-5809(03)00010-8

Journal articles | 2002

Tanaka MM; Kumm J; Feldman MW, 2002, 'Coevolution of Pathogens and Cultural Practices: A New Look at Behavioral Heterogeneity in Epidemics', Theoretical Population Biology, vol. 62, pp. 111 - 119, http://dx.doi.org/10.1006/tpbi.2002.1585

Journal articles | 2001

Tanaka MM; Rosenberg NA, 2001, 'Optimal estimation of transposition rates of insertion sequences for molecular epidemiology', Statistics in Medicine, vol. 20, pp. 2409 - 2420, http://dx.doi.org/10.1002/sim.910

Journal articles | 2000

Tanaka MM; Small PM; Salamon H; Feldman MW, 2000, 'The dynamics of repeated elements: Applications to the epidemiology of tuberculosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, pp. 3532 - 3537, http://dx.doi.org/10.1073/pnas.97.7.3532

Journal articles | 2000

Rhee JT; Tanaka MM; Behr MA; Agasino CB; Paz EA; Hopewell PC; Small PM, 2000, 'Use of multiple markers in population-based molecular epidemiologic studies of tuberculosis', International Journal of Tuberculosis and Lung Disease, vol. 4, pp. 1111 - 1119

Journal articles | 1999

Field D; Magnasco MO; Moxon ER; Metzgar D; Tanaka MM; Wills C; Thaler DS, 1999, 'Contingency loci, mutator alleles, and their interactions. Synergistic strategies for microbial evolution and adaptation in pathogenesis', Annals of the New York Academy of Sciences, vol. 870, pp. 378 - 381, http://dx.doi.org/10.1111/j.1749-6632.1999.tb08907.x

Journal articles | 1999

Tanaka MM; Feldman MW, 1999, 'Theoretical considerations of cross-immunity, recombination and the evolution of new parasitic strains', Journal of Theoretical Biology, vol. 198, pp. 145 - 163, http://dx.doi.org/10.1006/jtbi.1999.0906

Journal articles | 1997

Tanaka MM; Liang XM; Gray YHM; Sved JA, 1997, 'The accumulation of P-element-induced recombinants in the germline of male Drosophila melanogaster', Genetics, vol. 147, pp. 1769 - 1782

Journal articles | 1996

Gray YHM; Tanaka MM; Sved JA, 1996, 'P-element-induced recombination in Drosophila melanogaster: Hybrid element insertion', Genetics, vol. 144, pp. 1601 - 1610

Journal articles | 2019

Zhang E; Thibaut L; Terauds A; Wong S; van Dorst J; Tanaka M; Ferrari B, 2019, 'Extreme niche partitioning promotes a remarkably high diversity of soil microbiomes across eastern Antarctica', , http://dx.doi.org/10.1101/559666
Preprints | 2016

Serdoz S; Egri-Nagy A; Sumner J; Holland BR; Jarvis PD; Tanaka MM; Francis AR, 2016, Maximum likelihood estimates of pairwise rearrangement distances

Preprints | 2014

Egri-Nagy A; Gebhardt V; Tanaka MM; Francis AR, 2014, Group-theoretic models of the inversion process in bacterial genomes

Preprints |

Luo L; Payne M; Kaur S; Hu D; Cheney L; Octavia S; Wang Q; Tanaka MM; Sintchenko V; Lan R, Elucidation of global and local genomic epidemiology of Salmonella enterica serovar Enteritidis through multilevel genome typing, http://dx.doi.org/10.1101/2020.06.30.169953

Preprints |

Zhang E; Czechowski P; Terauds A; Wong SY; Chelliah DS; Raven M; Tanaka MM; Ferrari BC, Tracing boundaries in Eastern Antarctica: Multi-scale drivers of soil microbial communities across the hyperarid Vestfold Hills, http://dx.doi.org/10.1101/2021.09.22.461446

Preprints |

Francis A; Guo Y; Hurley P; Obst O; Park L; Tanaka M; Thomson R; Wang XR, Projected ICU and Mortuary load due to COVID-19 in Sydney, http://dx.doi.org/10.1101/2020.03.31.20049312

Preprints |

Chan CHS; Sanders LP; Tanaka MM, Modelling the role of immunity in reversion of viral antigenic sites, http://dx.doi.org/10.1101/027995

Journal articles | 2019

Russo AG; Kelly AG; Tuipulotu DE; Tanaka MM; White PA, 2019, 'Novel insights into endogenous RNA viral elements in Ixodes scapularis and other arbovirus vector genomes', Virus Evolution, vol. 5, http://dx.doi.org/10.1093/ve/vez010

Awards

Future Fellowship (Australian Research Council) 2014-2018
Moran Medal, Australian Academy of Science (jointly with S. A. Sisson) 2011
QEII Fellowship (Australian Research Council) 2009-2013

Grants

Selected research grants

Australian Research Council Discovery Project 2021-2023, How can cultural innovations trigger the emergence of new diseases? CI: M. Tanaka, PI: J. Kendal
National Health & Medical Research Council Project Grant 2018-2020, Reducing pertussis burden by optimising molecular epidemiological surveillance of epidemic Bordetella pertussis in Australia. CIs: R. Lan, V. Sintchenko, F. Mooi, M. Tanaka
Australian Research Council Discovery Project 2017-2019, New models linking microbial natural history and molecular evolution. CIs: M. Tanaka and R. Lan
National Health & Medical Research Council Project Grant 2017-2019, Optimising temporal genomic surveillance of Salmonella infections in Australia. CIs: R. Lan, V. Sintchenko, M. Tanaka, S. Octavia
National Health & Medical Research Council Project Grant 2017-2019, Assessing acellular pertussis vaccine effectiveness: integrating transmission models, genetics and cohort data to inform policy. CIs: J. Wood, M. Tanaka, R. Lan, P. McIntyre, H. Gidding, P. Campbell
Australian Research Council Linkage Project 2016-2018, Elucidating the genetic basis of newly evolved metabolic functions in yeast. CIs: R. Edwards, M. Wilkins, M. Tanaka, P. Attfield, P. Bell
Australian Research Council Future Fellowship 2014-2018, How microbes build their environments through evolutionary feedback. CI: M. Tanaka
National Health & Medical Research Council Project Grant 2013-2015, Molecular epidemiology and high resolution surveillance of Salmonella enterica serovar Typhimurium in Australia. CIs: R. Lan, V. Sintchenko, M. Tanaka, S. Octavia
Australian Research Council Discovery Project 2011-2013, Understanding mutation and genetic reassortment in viruses: New mathematical models of viral dynamics and evolution. CIs: M. Tanaka, P. White, K. Koelle, R. Regoes
Australian Research Council Discovery Project 2009--2013, Mathematical models and bioinformatic analyses of bacterial genome evolution. CIs: M. Tanaka, A. Francis and R. Lan
Australian Academy of Science, Scientific Visits to Europe 2006. CI: M. Tanaka
Australian Research Council Discovery Project 2005-2007, Evolutionary models and bioinformatic analyses of genetic variation in pathogens. CIs: M. Tanaka and A. Francis.

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Coordinator of Microbial Genetics (BABS3021/MICR3621)
Lecturer: Genes, Genomes and Evolution (BABS3291), Genetics (BABS2204/2264), Microbiology (MICR2011), Applied Biomolecular Sciences (BABS1202) and other courses.