Associate Professor Maté Biro
Associate Professor

Associate Professor Maté Biro

Medicine & Health
School of Clinical Medicine

Visit the Biro Group website at EMBL Australia

 

 

 

 

 


Dr Maté Biro received his PhD with summa cum laude at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. 

Dr. Biro has previously worked at the Centenary Institute of Cancer Medicine and Cell Biology in Sydney, in the Imaging Informatics division at the Bioinformatics Institute of A*STAR in Singapore, at the MIT BioImaging Center in Cambridge, MA, USA and in the Belle collaboration at the KEK: High Energy Accelerator Research Organisation in Tsukuba, Japan.

As an EMBL Australia Group Leader he will expand his exciting studies on the way actomyosin complexes control cell shape, homeostasis and migration in cancer and immune function, focusing on the elucidation of biomechanical interaction within and between cells.

Dr. Biro is spearheading the use of complex in vitro and in vivo models for studying the cell-intrinsic actin cytoskeleton cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning of T cells and their cytotoxic interaction with tumour cells. Using a multidisciplinary approach encompassing cell biology, biophysics, bioimage informatics and advanced light microscopy, he aims to unravel fundamental actin-based processes and develop new methodologies for basic cell biological research. Dr. Biro's research relies heavily on advanced microscopy and the development of image analysis platforms capable of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions.

Dr. Biro's group is primarily concerned with the cell biology and mechanics of the actin cytoskeleton, and how immune cells (T cells) locate and kill cancer cells.

Main research topics are:

  • Mechanobiology of immune cell-tumour cell interactions
  • Single cell and population-wide immune cell migration dynamics
  • Advanced imaging and image analysis
  • Computational modelling and simulations

The group uses high-speed imaging to watch how cells move throughout complex 3-dimensional environments and also uses single molecule microscopes to observe the dynamics of actomyosin, a major and the force-generating component of the cytoskeleton.

When he is not involved with research Dr. Biro enjoys flying all things powered or unpowered and discovering the marvels of the underwater world whilst diving. He is also always happy to discuss his research and other passions over a beer...

Phone
+61293858020
Location
EMBL Australia node in Single Molecule Science Level 3, Lowy Cancer Research Centre (C25)
  • Book Chapters | 2015
    Biro M; Maître JL, 2015, 'Dual pipette aspiration: Aunique tool for studying intercellular adhesion', in Methods in Cell Biology, pp. 255 - 267, http://dx.doi.org/10.1016/bs.mcb.2014.10.007
  • Journal articles | 2022
    Govendir MA; Kempe D; Sianati S; Cremasco J; Mazalo JK; Colakoglu F; Golo M; Poole K; Biro M, 2022, 'T cell cytoskeletal forces shape synapse topography for targeted lysis via membrane curvature bias of perforin', Developmental Cell, vol. 57, pp. 2237 - 2247.e8, http://dx.doi.org/10.1016/j.devcel.2022.08.012
    Journal articles | 2020
    Niño JLG; Pageon SV; Tay SS; Colakoglu F; Kempe D; Hywood J; Mazalo JK; Cremasco J; Govendir MA; Dagley LF; Hsu K; Rizzetto S; Zieba J; Rice G; Prior V; O’neill G; Williams RJ; Nisbet DR; Kramer B; Webb AI; Luciani F; Read MN; Biro M, 2020, 'Cytotoxic T cells swarm by homotypic chemokine signalling', eLife, vol. 9, pp. 1 - 71, http://dx.doi.org/10.7554/eLife.56554
    Journal articles | 2019
    Redpath GMI; Ecker M; Kapoor-Kaushik N; Vartoukian H; Carnell M; Kempe D; Biro M; Ariotti N; Rossy J, 2019, 'Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-12352-w
    Journal articles | 2018
    Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CML; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05772-7
    Journal articles | 2017
    Marshal AD; Bailey CG; Champ K; Vellozzi M; O'Young P; Metierre C; Feng Y; Thoeng A; Richards AM; Schmitz U; Biro M; Jayasinghe R; Ding L; Anderson L; Mardis ER; Rasko JEJ, 2017, 'CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic', Oncogene, vol. 36, pp. 4100 - 4110, http://dx.doi.org/10.1038/onc.2017.25
    Journal articles | 2016
    Galeano Niño JL; Kwan RYQ; Weninger W; Biro M, 2016, 'Antigen-specific T cells fully conserve antitumour function following cryopreservation', Immunology and Cell Biology, vol. 94, pp. 411 - 418, http://dx.doi.org/10.1038/icb.2015.105
    Journal articles | 2016
    Sedzinski J; Hannezo E; Tu F; Biro M; Wallingford JB, 2016, 'Emergence of an Apical Epithelial Cell Surface In Vivo', Developmental Cell, vol. 36, pp. 24 - 35, http://dx.doi.org/10.1016/j.devcel.2015.12.013
    Journal articles | 2015
    Tong PL; Roediger B; Kolesnikoff N; Biro M; Tay SS; Jain R; Shaw LE; Grimbaldeston MA; Weninger W, 2015, 'The skin immune atlas: Three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy', Journal of Investigative Dermatology, vol. 135, pp. 84 - 93, http://dx.doi.org/10.1038/jid.2014.289
    Journal articles | 2014
    Bovellan M; Romeo Y; Biro M; Boden A; Chugh P; Yonis A; Vaghela M; Fritzsche M; Moulding D; Thorogate R; Jégou A; Thrasher AJ; Romet-Lemonne G; Roux PP; Paluch EK; Charras G, 2014, 'Cellular control of cortical actin nucleation', Current Biology, vol. 24, pp. 1628 - 1635, http://dx.doi.org/10.1016/j.cub.2014.05.069
    Journal articles | 2014
    Munoz MA; Biro M; Weninger W, 2014, 'T cell migration in intact lymph nodes in vivo', Current Opinion in Cell Biology, vol. 30, pp. 17 - 24, http://dx.doi.org/10.1016/j.ceb.2014.05.002
    Journal articles | 2014
    Weninger W; Biro M; Jain R, 2014, 'Leukocyte migration in the interstitial space of non-lymphoid organs', Nature Reviews Immunology, vol. 14, pp. 232 - 246, http://dx.doi.org/10.1038/nri3641