Senior Research Fellow

Dr Matt Paradise

medicine-health
Centre for Healthy BrainAgeing

Matt is an Old Age Psychiatrist who trained both in the UK and Australia, receiving a Masters of Psychiatric Research from University College London (UCL). He is finishing his PhD in vascular cognitive impairment and neuroimaging with Professor Perminder Sachdev AM, Co-Director of CHeBA.

Matt’s dual role as clinician and researcher has developed his unique understanding of the dementia experience. In his clinical capacity he works within South West Sydney Local Health District. His research interests include late-life depression, mild-cognitive impairment, cerebrovascular imaging, dementia service development and dementia risk-reduction.

He is the recipient of a Dementia Centre for Research Collaboration grant to develop a novel MRI-based cerebrovascular pathology index, and was the inaugural recipient of the Josh Woolfson Memorial Scholarship which supports research looking at modifiable risk factors for Alzheimer’s disease to identify and target at-risk groups and individuals and develop intervention strategies for risk reduction.

He is part of the Neuroimaging and Neuropsychiatry Groups at the Centre for Healthy Brain Ageing within the School of Psychiatry.

Meet Our Researcher
Click here to read Dr Matt Paradise's ‘Meet Our Researcher’ interview

Publications

  • Book Chapters | 2015
    Dr Matt Paradise
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood, and sleep', in Handbook of Depression in Alzheimer's Disease, pp. 355 - 366, http://dx.doi.org/10.3233/978-1-61499-542-5-355
  • Journal articles | 2021
    Dr Matt Paradise
    Paradise M; Crawford JD; Lam BCP; Wen W; Kochan NA; Makkar S; Dawes L; Trollor J; Draper B; Brodaty H; Sachdev PS, 2021, 'Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia', Neurology, vol. 96, pp. e1501 - e1511, http://dx.doi.org/10.1212/WNL.0000000000011537
    Journal articles | 2020
    Dr Matt Paradise
    Liu Y; Chan DKY; Thalamuthu A; Wen W; Jiang J; Paradise M; Lee T; Crawford J; Wai Kin Wong M; Hua Xu Y; Poljak A; Pickford R; Sachdev PS; Braidy N, 2020, 'Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia', Computational and Structural Biotechnology Journal, vol. 18, pp. 1613 - 1624, http://dx.doi.org/10.1016/j.csbj.2020.06.001
    Journal articles | 2019
    Dr Matt Paradise
    Paradise M; Sachdev PS, 2019, 'Vascular cognitive disorders', Seminars in Neurology, vol. 39, pp. 241 - 250, http://dx.doi.org/10.1055/s-0039-1678582
    Journal articles | 2019
    Dr Matt Paradise
    Paradise MB; Beaudoin MS; Dawes L; Crawford JD; Wen W; Brodaty H; Sachdev PS, 2019, 'Development and validation of a rating scale for perivascular spaces on 3T MRI', Journal of the Neurological Sciences, vol. 409, pp. 116621 - 116621, http://dx.doi.org/10.1016/j.jns.2019.116621
    Journal articles | 2019
    Dr Matt Paradise
    Paradise M; Seruga A; Crawford JD; Chaganti J; Thalamuthu A; Kochan NA; Brodaty H; Wen W; Sachdev PS, 2019, 'The relationship of cerebral microbleeds to cognition and incident dementia in non-demented older individuals', Brain Imaging and Behavior, vol. 13, pp. 750 - 761, http://dx.doi.org/10.1007/s11682-018-9883-3
    Journal articles | 2019
    Dr Matt Paradise
    Paradise DM, 2019, 'Commentary on: Mechanisms Linking White Matter Lesions, Tract Integrity and Depression in Alzheimer's Disease', American Journal of Geriatric Psychiatry, vol. 27, pp. 960 - 962, http://dx.doi.org/10.1016/j.jagp.2019.05.010
    Journal articles | 2018
    Dr Matt Paradise
    Jiang J; Paradise M; Liu T; Armstrong NJ; Zhu W; Kochan N; Brodaty H; Sachdev PS; Wen W, 2018, 'The association of regional white matter lesions with cognition in a community-based cohort of older individuals', NeuroImage: Clinical, vol. 19, pp. 14 - 21, http://dx.doi.org/10.1016/j.nicl.2018.03.035
    Journal articles | 2018
    Dr Matt Paradise
    Paradise M; Shepherd CE; Wen W; Sachdev PS, 2018, 'Neuroimaging and neuropathology indices of cerebrovascular disease burden: A systematic review', Neurology, vol. 91, pp. 310 - 320, http://dx.doi.org/10.1212/wnl.0000000000005997
    Journal articles | 2015
    Dr Matt Paradise
    Paradise M; Mccade D; Hickie IB; Diamond K; Lewis SJG; Naismith SL, 2015, 'Caregiver burden in mild cognitive impairment', Aging and Mental Health, vol. 19, pp. 72 - 78, http://dx.doi.org/10.1080/13607863.2014.915922
    Journal articles | 2015
    Dr Matt Paradise
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep', Journal of Alzheimer's disease : JAD, vol. 44, pp. 1181 - 1191, http://dx.doi.org/10.3233/JAD-142061
    Journal articles | 2015
    Dr Matt Paradise
    Jayaweera HK; Hickie IB; Duffy SL; Hermens DF; Mowszowski L; Diamond K; Terpening Z; Paradise M; Lewis SJG; Lagopoulos J; Naismith SL, 2015, 'Mild Cognitive Impairment Subtypes in Older People with Depressive Symptoms: Relationship with Clinical Variables and Hippocampal Change', Journal of Geriatric Psychiatry and Neurology, vol. 28, pp. 174 - 183, http://dx.doi.org/10.1177/0891988715573535
    Journal articles | 2015
    Dr Matt Paradise
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood, and sleep', Advances in Alzheimer's Disease, vol. 4, pp. 355 - 365, http://dx.doi.org/10.3233/978-1-61499-542-5-355
    Journal articles | 2014
    Dr Matt Paradise
    Elcombe EL; Lagopoulos J; Mowszowski L; Diamond K; Paradise M; Hickie IB; Lewis SJG; Naismith SL, 2014, 'Clinical and cognitive correlates of structural hippocampal change in "at-risk" older adults', Journal of Geriatric Psychiatry and Neurology, vol. 27, pp. 67 - 76, http://dx.doi.org/10.1177/0891988713509137
    Journal articles | 2014
    Dr Matt Paradise
    Duffy SL; Paradise M; Hickie IB; Lewis SJG; Naismith SL; Lagopoulos J, 2014, 'Cognitive impairment with and without depression history: An analysis of white matter microstructure', Journal of Psychiatry and Neuroscience, vol. 39, pp. 135 - 143, http://dx.doi.org/10.1503/jpn.130079
    Journal articles | 2012
    Dr Matt Paradise
    Paradise MB; Naismith SL; Davenport TA; Hickie IB; Glozier NS, 2012, 'The impact of gender on early ill-health retirement in people with heart disease and depression', Australian and New Zealand Journal of Psychiatry, vol. 46, pp. 249 - 256, http://dx.doi.org/10.1177/0004867411427807
    Journal articles | 2012
    Dr Matt Paradise
    Paradise MB; Naismith SL; Norrie LM; Graeber MB; Hickie IB, 2012, 'The role of glia in late-life depression', International Psychogeriatrics, vol. 24, pp. 1878 - 1890, http://dx.doi.org/10.1017/S1041610212000828
    Journal articles | 2012
    Dr Matt Paradise
    Mowszowski L; Ward PB; Diamond K; Paradise M; Kaur M; Lewis SJG; Hickie I; Hermens DF; Naismith S, 2012, 'Reduced temporal mismatch negativity in late-life depression: An event-related potential index of cognitive deficit and functional disability?', Journal of Affective Disorders, vol. 138, pp. 71 - 78, http://dx.doi.org/10.1016/j.jad.2011.12.028
    Journal articles | 2011
    Dr Matt Paradise
    Paradise MB; Glozier NS; Naismith SL; Davenport TA; Hickie IB, 2011, 'Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: A cross-sectional study', BMC Psychiatry, vol. 11, http://dx.doi.org/10.1186/1471-244X-11-108
    Journal articles | 2009
    Dr Matt Paradise
    Paradise M; Walker Z; Cooper C; Blizard R; Regan C; Katona C; Livingston G, 2009, 'Prediction of survival in Alzheimer's disease - The LASER-AD longitudinal study', International Journal of Geriatric Psychiatry, vol. 24, pp. 739 - 747, http://dx.doi.org/10.1002/gps.2190
    Journal articles | 2009
    Dr Matt Paradise
    Paradise M; Cooper C; Livingston G, 2009, 'Systematic review of the effect of education on survival in Alzheimer's disease', International Psychogeriatrics, vol. 21, pp. 25 - 32, http://dx.doi.org/10.1017/S1041610208008053
  • Conference Abstracts | 2019
    Dr Matt Paradise
    Paradise MB; Wen W; Sachdev PS, 2019, 'Perivascular spaces are associated with longitudinal cognitive decline and incident dementia in a healthy older cohort [Poster Abstract P3-311]', in Alzheimer's & Dementia, Elsevier BV, Los Angeles, CA, USA, Vol. 15, pp. P1410 - P1411, presented at Alzheimer's Association International Conference (AAIC) 2019, Los Angeles, CA, USA, 14 July 2019 - 16 July 2019, http://dx.doi.org/10.1016/j.jalz.2019.06.3981

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