Senior Lecturer

Dr Matthew Perry

medicine-health
School of Medical Sciences

Publications

  • Book Chapters | 2014
    Dr Matthew Perry
    Vandenberg JI; Ng CA; Mann SA; Perry MD, 2014, 'Voltage-Gated Potassium Channels (Kv10-Kv12)', in Reference Module in Biomedical Research, http://dx.doi.org/10.1016/B978-0-12-801238-3.04809-1
  • Journal articles | 2020
    Dr Matthew Perry
    Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, vol. 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247
    Journal articles | 2020
    Dr Matthew Perry
    Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, vol. 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
    Journal articles | 2020
    Dr Matthew Perry
    Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2020, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events.', Cardiovasc Res, http://dx.doi.org/10.1093/cvr/cvaa280
    Journal articles | 2019
    Dr Matthew Perry
    Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, vol. 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220
    Journal articles | 2017
    Dr Matthew Perry
    Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, vol. 6, http://dx.doi.org/10.12688/f1000research.11855.1
    Journal articles | 2017
    Dr Matthew Perry
    Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, vol. 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298
    Journal articles | 2016
    Dr Matthew Perry
    Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, vol. 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015
    Journal articles | 2016
    Dr Matthew Perry
    Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, vol. 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011
    Journal articles | 2016
    Dr Matthew Perry
    Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, vol. 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
    Journal articles | 2016
    Dr Matthew Perry
    Perry MD; Rajendran VM; MacLennan KA; Sandle GI, 2016, 'Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.', Am J Physiol Gastrointest Liver Physiol, vol. 311, pp. G785 - G793, http://dx.doi.org/10.1152/ajpgi.00181.2015
    Journal articles | 2016
    Dr Matthew Perry
    Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, vol. 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392
    Journal articles | 2015
    Dr Matthew Perry
    Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, vol. 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275
    Journal articles | 2015
    Dr Matthew Perry
    Brignell JL; Perry MD; Nelson CP; Willets JM; Challiss RAJ; Davies NW, 2015, 'Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0121285
    Journal articles | 2015
    Dr Matthew Perry
    Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, vol. 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
    Journal articles | 2014
    Dr Matthew Perry
    Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
    Journal articles | 2014
    Dr Matthew Perry
    Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277
    Journal articles | 2014
    Dr Matthew Perry
    Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6069
    Journal articles | 2014
    Dr Matthew Perry
    Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, vol. 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568
    Journal articles | 2013
    Dr Matthew Perry
    Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, vol. 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975
    Journal articles | 2013
    Dr Matthew Perry
    Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0077032
    Journal articles | 2012
    Dr Matthew Perry
    Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, vol. 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
    Journal articles | 2011
    Dr Matthew Perry
    Nelson CP; Rainbow RD; Brignell JL; Perry MD; Willets JM; Davies NW; Standen NB; Challiss RAJ, 2011, 'Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.', Cardiovasc Res, vol. 91, pp. 694 - 702, http://dx.doi.org/10.1093/cvr/cvr137
    Journal articles | 2010
    Dr Matthew Perry
    Perry M; Sanguinetti M; Mitcheson J, 2010, 'Revealing the structural basis of action of hERG potassium channel activators and blockers.', J Physiol, vol. 588, pp. 3157 - 3167, http://dx.doi.org/10.1113/jphysiol.2010.194670
    Journal articles | 2009
    Dr Matthew Perry
    Perry M; Sachse FB; Abbruzzese J; Sanguinetti MC, 2009, 'PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.', Proc Natl Acad Sci U S A, vol. 106, pp. 20075 - 20080, http://dx.doi.org/10.1073/pnas.0906597106
    Journal articles | 2009
    Dr Matthew Perry
    Perry MD; Sandle GI, 2009, 'Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.', Am J Physiol Gastrointest Liver Physiol, vol. 297, pp. G159 - G167, http://dx.doi.org/10.1152/ajpgi.00132.2009
    Journal articles | 2008
    Dr Matthew Perry
    Perry M; Sanguinetti MC, 2008, 'A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.', Mol Pharmacol, vol. 73, pp. 1044 - 1051, http://dx.doi.org/10.1124/mol.107.043018
    Journal articles | 2007
    Dr Matthew Perry
    Perry M; Sachse FB; Sanguinetti MC, 2007, 'Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.', Proc Natl Acad Sci U S A, vol. 104, pp. 13827 - 13832, http://dx.doi.org/10.1073/pnas.0703934104
    Journal articles | 2007
    Dr Matthew Perry
    Sandle GI; Perry MD; Mathialahan T; Linley JE; Robinson P; Hunter M; MacLennan KA, 2007, 'Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis.', J Pathol, vol. 212, pp. 66 - 73, http://dx.doi.org/10.1002/path.2159
    Journal articles | 2006
    Dr Matthew Perry
    Perry M; Stansfeld PJ; Leaney J; Wood C; De Groot MJ; Leishman D; Sutcliffe MJ; Mitcheson JS, 2006, 'Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs', Molecular Pharmacology, vol. 69, pp. 509 - 519, http://dx.doi.org/10.1124/mol.105.016741
    Journal articles | 2004
    Dr Matthew Perry
    Perry M; De Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J, 2004, 'Structural determinants of HERG channel block by clofilium and ibutilide', Molecular Pharmacology, vol. 66, pp. 240 - 249, http://dx.doi.org/10.1124/mol.104.000117
    Journal articles | 2004
    Dr Matthew Perry
    Witchel HJ; Dempsey CE; Sessions RB; Perry M; Milnes JT; Hancox JC; Mitcheson JS, 2004, 'The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.', Mol Pharmacol, vol. 66, pp. 1201 - 1212, http://dx.doi.org/10.1124/mol.104.001743
  • Other | 2016
    Dr Matthew Perry
    Perry MD; Vandenberg JI, 2016, TECRL: Connecting sequence to consequence for a new sudden cardiac death gene, http://dx.doi.org/10.15252/emmm.201606967
    Conference Abstracts | 2014
    Dr Matthew Perry
    Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493
    Conference Abstracts | 2012
    Dr Matthew Perry
    Perry MD; Vandenberg JI, 2012, 'Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1801
    Conference Papers | 2012
    Dr Matthew Perry
    Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800

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