Senior Lecturer

Dr Matthew Perry

Medicine & Health
Pharmacology

Publications

  • Book Chapters | 2014
    Vandenberg JI; Ng CA; Mann SA; Perry MD, 2014, 'Voltage-Gated Potassium Channels (Kv10-Kv12)', in Reference Module in Biomedical Research, http://dx.doi.org/10.1016/B978-0-12-801238-3.04809-1
    Book Chapters | 2011
    Sanguinetti MC; Perry M, 2011, 'hERG1 Channel Blockers and Cardiac Arrhythmia', in Heart Rate and Rhythm, Springer Berlin Heidelberg, pp. 611 - 625, http://dx.doi.org/10.1007/978-3-642-17575-6_34
    Book Chapters | 2005
    Mitcheson J; Perry M; Stansfeld P; Sanguinetti MC; Witchel H; Hancox J, 2005, 'Structural determinants for high-affinity block of hERG potassium channels.', in , pp. 136 - 150, https://www.ncbi.nlm.nih.gov/pubmed/16050266
  • Journal articles | 2020
    Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, vol. 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247
    Journal articles | 2020
    Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, vol. 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
    Journal articles | 2021
    Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, vol. 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280
    Journal articles | 2019
    Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, vol. 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220
    Journal articles | 2017
    Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, vol. 6, http://dx.doi.org/10.12688/f1000research.11855.1
    Journal articles | 2017
    Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, vol. 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298
    Journal articles | 2016
    Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, vol. 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015
    Journal articles | 2016
    Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, vol. 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011
    Journal articles | 2016
    Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, vol. 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
    Journal articles | 2016
    Perry MD; Rajendran VM; MacLennan KA; Sandle GI, 2016, 'Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.', Am J Physiol Gastrointest Liver Physiol, vol. 311, pp. G785 - G793, http://dx.doi.org/10.1152/ajpgi.00181.2015
    Journal articles | 2016
    Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, vol. 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392
    Journal articles | 2015
    Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, vol. 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275
    Journal articles | 2015
    Brignell JL; Perry MD; Nelson CP; Willets JM; Challiss RAJ; Davies NW, 2015, 'Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0121285
    Journal articles | 2015
    Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, vol. 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
    Journal articles | 2014
    Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
    Journal articles | 2014
    Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277
    Journal articles | 2014
    Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6069
    Journal articles | 2014
    Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, vol. 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568
    Journal articles | 2013
    Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, vol. 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975
    Journal articles | 2013
    Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0077032
    Journal articles | 2012
    Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, vol. 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
    Journal articles | 2011
    Nelson CP; Rainbow RD; Brignell JL; Perry MD; Willets JM; Davies NW; Standen NB; Challiss RAJ, 2011, 'Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.', Cardiovasc Res, vol. 91, pp. 694 - 702, http://dx.doi.org/10.1093/cvr/cvr137
    Journal articles | 2010
    Perry M; Sanguinetti M; Mitcheson J, 2010, 'Revealing the structural basis of action of hERG potassium channel activators and blockers.', J Physiol, vol. 588, pp. 3157 - 3167, http://dx.doi.org/10.1113/jphysiol.2010.194670
    Journal articles | 2009
    Perry M; Sachse FB; Abbruzzese J; Sanguinetti MC, 2009, 'PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.', Proc Natl Acad Sci U S A, vol. 106, pp. 20075 - 20080, http://dx.doi.org/10.1073/pnas.0906597106
    Journal articles | 2009
    Perry MD; Sandle GI, 2009, 'Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.', Am J Physiol Gastrointest Liver Physiol, vol. 297, pp. G159 - G167, http://dx.doi.org/10.1152/ajpgi.00132.2009
    Journal articles | 2008
    Perry M; Sanguinetti MC, 2008, 'A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.', Mol Pharmacol, vol. 73, pp. 1044 - 1051, http://dx.doi.org/10.1124/mol.107.043018
    Journal articles | 2007
    Perry M; Sachse FB; Sanguinetti MC, 2007, 'Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.', Proc Natl Acad Sci U S A, vol. 104, pp. 13827 - 13832, http://dx.doi.org/10.1073/pnas.0703934104
    Journal articles | 2007
    Sandle GI; Perry MD; Mathialahan T; Linley JE; Robinson P; Hunter M; MacLennan KA, 2007, 'Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis.', J Pathol, vol. 212, pp. 66 - 73, http://dx.doi.org/10.1002/path.2159
    Journal articles | 2006
    Perry M; Stansfeld PJ; Leaney J; Wood C; De Groot MJ; Leishman D; Sutcliffe MJ; Mitcheson JS, 2006, 'Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs', Molecular Pharmacology, vol. 69, pp. 509 - 519, http://dx.doi.org/10.1124/mol.105.016741
    Journal articles | 2004
    Perry M; De Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J, 2004, 'Structural determinants of HERG channel block by clofilium and ibutilide', Molecular Pharmacology, vol. 66, pp. 240 - 249, http://dx.doi.org/10.1124/mol.104.000117
    Journal articles | 2004
    Witchel HJ; Dempsey CE; Sessions RB; Perry M; Milnes JT; Hancox JC; Mitcheson JS, 2004, 'The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.', Mol Pharmacol, vol. 66, pp. 1201 - 1212, http://dx.doi.org/10.1124/mol.104.001743
    Journal articles | 2021
    Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, vol. 6, pp. bpab003, http://dx.doi.org/10.1093/biomethods/bpab003
    Journal articles | 2021
    Ross S; Holliday M; Lim S; Mangala M; Perry M; Gray B; Fraser S; Hill A; Hudson J; Semsarian C, 2021, 'Functional Analysis of a Novel Heterozygous Variant in CASQ2 as a Distinct Cause of Catecholaminergic Polymorphic Ventricular Tachycardia', Heart, Lung and Circulation, vol. 30, pp. S96 - S96, http://dx.doi.org/10.1016/j.hlc.2021.06.016
    Journal articles | 2018
    Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, vol. 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039
    Journal articles | 2018
    Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, vol. 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309
    Journal articles | 2003
    Mitcheson JS; Perry MD, 2003, 'Molecular determinants of high-affinity drug binding to HERG channels.', Curr Opin Drug Discov Devel, vol. 6, pp. 667 - 674, https://www.ncbi.nlm.nih.gov/pubmed/14579516
    Book Chapters | 2014
    Vandenberg JI; Ng CA; Mann SA; Perry MD, 2014, 'Voltage-Gated Potassium Channels (Kv10-Kv12)', in Reference Module in Biomedical Research, http://dx.doi.org/10.1016/B978-0-12-801238-3.04809-1
    Book Chapters | 2011
    Sanguinetti MC; Perry M, 2011, 'hERG1 Channel Blockers and Cardiac Arrhythmia', in Heart Rate and Rhythm, Springer Berlin Heidelberg, pp. 611 - 625, http://dx.doi.org/10.1007/978-3-642-17575-6_34
    Book Chapters | 2005
    Mitcheson J; Perry M; Stansfeld P; Sanguinetti MC; Witchel H; Hancox J, 2005, 'Structural determinants for high-affinity block of hERG potassium channels.', in , pp. 136 - 150, https://www.ncbi.nlm.nih.gov/pubmed/16050266
  • Other | 2016
    Perry MD; Vandenberg JI, 2016, TECRL: Connecting sequence to consequence for a new sudden cardiac death gene, http://dx.doi.org/10.15252/emmm.201606967
    Conference Abstracts | 2014
    Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493
    Conference Abstracts | 2012
    Perry MD; Vandenberg JI, 2012, 'Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1801
    Conference Abstracts | 2012
    Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800
    Conference Abstracts |
    Phan K; Ng C; McNitt S; Moss A; Zareba W; Perry M; Vandenberg J, 'The role of in vitro phenotypes for clinical risk stratification of sudden death in Long QT Syndrome Type 2', in Heart, Lung and Circulation, Elsevier, Vol. 24, pp. S232 - S233, presented at Heart, Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2015.06.289
    Journal articles | 2021
    Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, vol. 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280
    Journal articles | 2021
    Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, vol. 6, pp. bpab003, http://dx.doi.org/10.1093/biomethods/bpab003
    Journal articles | 2021
    Ross S; Holliday M; Lim S; Mangala M; Perry M; Gray B; Fraser S; Hill A; Hudson J; Semsarian C, 2021, 'Functional Analysis of a Novel Heterozygous Variant in CASQ2 as a Distinct Cause of Catecholaminergic Polymorphic Ventricular Tachycardia', Heart, Lung and Circulation, vol. 30, pp. S96 - S96, http://dx.doi.org/10.1016/j.hlc.2021.06.016
    Journal articles | 2020
    Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, vol. 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
    Journal articles | 2020
    Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, vol. 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247
    Journal articles | 2019
    Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, vol. 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220
    Journal articles | 2018
    Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, vol. 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039
    Journal articles | 2018
    Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, vol. 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309
    Journal articles | 2017
    Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, vol. 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298
    Journal articles | 2017
    Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, vol. 6, http://dx.doi.org/10.12688/f1000research.11855.1
    Journal articles | 2016
    Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, vol. 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011
    Journal articles | 2016
    Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, vol. 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392
    Journal articles | 2016
    Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, vol. 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
    Journal articles | 2016
    Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, vol. 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015
    Journal articles | 2016
    Perry MD; Rajendran VM; MacLennan KA; Sandle GI, 2016, 'Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.', Am J Physiol Gastrointest Liver Physiol, vol. 311, pp. G785 - G793, http://dx.doi.org/10.1152/ajpgi.00181.2015
    Journal articles | 2015
    Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, vol. 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275
    Journal articles | 2015
    Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, vol. 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
    Journal articles | 2015
    Brignell JL; Perry MD; Nelson CP; Willets JM; Challiss RAJ; Davies NW, 2015, 'Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0121285
    Journal articles | 2014
    Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6069
    Journal articles | 2014
    Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
    Journal articles | 2014
    Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277
    Journal articles | 2014
    Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, vol. 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568
    Journal articles | 2013
    Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, vol. 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975
    Journal articles | 2013
    Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0077032
    Journal articles | 2012
    Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, vol. 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
    Journal articles | 2011
    Nelson CP; Rainbow RD; Brignell JL; Perry MD; Willets JM; Davies NW; Standen NB; Challiss RAJ, 2011, 'Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.', Cardiovasc Res, vol. 91, pp. 694 - 702, http://dx.doi.org/10.1093/cvr/cvr137
    Journal articles | 2010
    Perry M; Sanguinetti M; Mitcheson J, 2010, 'Revealing the structural basis of action of hERG potassium channel activators and blockers.', J Physiol, vol. 588, pp. 3157 - 3167, http://dx.doi.org/10.1113/jphysiol.2010.194670
    Journal articles | 2009
    Perry M; Sachse FB; Abbruzzese J; Sanguinetti MC, 2009, 'PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.', Proc Natl Acad Sci U S A, vol. 106, pp. 20075 - 20080, http://dx.doi.org/10.1073/pnas.0906597106
    Journal articles | 2009
    Perry MD; Sandle GI, 2009, 'Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.', Am J Physiol Gastrointest Liver Physiol, vol. 297, pp. G159 - G167, http://dx.doi.org/10.1152/ajpgi.00132.2009
    Journal articles | 2008
    Perry M; Sanguinetti MC, 2008, 'A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.', Mol Pharmacol, vol. 73, pp. 1044 - 1051, http://dx.doi.org/10.1124/mol.107.043018
    Journal articles | 2007
    Sandle GI; Perry MD; Mathialahan T; Linley JE; Robinson P; Hunter M; MacLennan KA, 2007, 'Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis.', J Pathol, vol. 212, pp. 66 - 73, http://dx.doi.org/10.1002/path.2159
    Journal articles | 2007
    Perry M; Sachse FB; Sanguinetti MC, 2007, 'Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.', Proc Natl Acad Sci U S A, vol. 104, pp. 13827 - 13832, http://dx.doi.org/10.1073/pnas.0703934104
    Journal articles | 2006
    Perry M; Stansfeld PJ; Leaney J; Wood C; De Groot MJ; Leishman D; Sutcliffe MJ; Mitcheson JS, 2006, 'Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs', Molecular Pharmacology, vol. 69, pp. 509 - 519, http://dx.doi.org/10.1124/mol.105.016741
    Journal articles | 2004
    Perry M; De Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J, 2004, 'Structural determinants of HERG channel block by clofilium and ibutilide', Molecular Pharmacology, vol. 66, pp. 240 - 249, http://dx.doi.org/10.1124/mol.104.000117
    Journal articles | 2004
    Witchel HJ; Dempsey CE; Sessions RB; Perry M; Milnes JT; Hancox JC; Mitcheson JS, 2004, 'The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.', Mol Pharmacol, vol. 66, pp. 1201 - 1212, http://dx.doi.org/10.1124/mol.104.001743
    Journal articles | 2003
    Mitcheson JS; Perry MD, 2003, 'Molecular determinants of high-affinity drug binding to HERG channels.', Curr Opin Drug Discov Devel, vol. 6, pp. 667 - 674, https://www.ncbi.nlm.nih.gov/pubmed/14579516

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