Dr Melanie Walker

Dr Melanie Walker

Postdoctoral Fellow
Medicine & Health
School of Biomedical Sciences

Qualifications: PhD

Bio: In 2013 Melanie commenced her PhD with Rowena Bull, Fabio Luciani and Andrew Lloyd where her researched focussed on understanding transmitted founder (T/F) virus phenotypic traits and neutralising antibody responses to TF viruses. In 2018, she moved to Copenhagen, Denmark for a postdoctoral position at the Centre for Medical Parasitology, University of Copenhagen. Here, her worked focussed on characterising the humoral immune response and monoclonal antibodies to malaria merozoite antigens and SARS-CoV-2 spike protein. Melanie moved back to Sydney in 2023 to join the VISP group as a postdoc. Her current project involves working with panels of HCV envelope antigens that will help guide the development of broadly neutralising antibodies.

Phone
83180024
Location
WW Lv5 532 E
  • Journal articles | 2024
    Partey FD; Dowuona JNN; Pobee ANA; Walker MR; Aculley B; Prah DA; Ofori MF; Barfod LK, 2024, 'Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults', Scientific Reports, 14, http://dx.doi.org/10.1038/s41598-024-55206-2
    Journal articles | 2024
    Underwood AP; Gupta M; Wu B-R; Eltahla AA; Boo I; Wang JJ; Agapiou D; Abayasingam A; Reynaldi A; Keoshkerian E; Zhao Y; Brasher N; Walker MR; Bukh J; Maher L; Gordon T; Davenport MP; Luciani F; Drummer HE; Lloyd AR; Bull RA, 2024, 'B cell characteristics define HCV reinfection outcome.', J Hepatol, http://dx.doi.org/10.1016/j.jhep.2024.04.004
    Journal articles | 2023
    Heron JE; McManus H; Vickers T; Ryan K; Wright E; Carter A; Stoove M; Asselin J; Grulich A; Donovan B; Guy R; Varma R; Chen M; Ryder N; Lewis DA; Templeton DJ; O’Connor CC; Gracey DM; Bastian L; Bateson D; Bowden S; Boyd M; Callander D; Aung HL; Cogle A; Costello J; Dimech W; Dittmer J; El-Hayek C; Ellard J; Fairley C; Franklin L; Hellard M; Hocking J; Kim J; McGill S; Nolan D; Patel P; Pendle S; Polkinghorne V; Nguyen L; Nguyen T; Reed P; Roth N; Selvey C; Traeger M; Walker M; West M, 2023, 'Renal impairment associated with tenofovir disoproxil fumarate for antiretroviral therapy and HIV pre-exposure prophylaxis: An observational cohort study', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0280339
    Journal articles | 2023
    Kaptoge S; Seshasai SRK; Sun L; Walker M; Bolton T; Spackman S; Ataklte F; Willeit P; Bell S; Burgess S; Pennells L; Altay S; Assmann G; Ben-Shlomo Y; Best LG; Björkelund C; Blazer DG; Brenner H; Brunner EJ; Dagenais GR; Cooper JA; Cooper C; Crespo CJ; Cushman M; D'Agostino RB; Daimon M; Daniels LB; Danker R; Davidson KW; de Jongh RT; Donfrancesco C; Ducimetiere P; Elders PJM; Engström G; Ford I; Gallacher I; Bakker SJL; Goldbourt U; de La Cámara G; Grimsgaard S; Gudnason V; Hansson PO; Imano H; Jukema JW; Kabrhel C; Kauhanen J; Kavousi M; Kiechl S; Knuiman MW; Kromhout D; Krumholz HM; Kuller LH; Laatikainen T; Lowler DA; Meyer HE; Mukamal K; Nietert PJ; Ninomiya T; Nitsch D; Nordestgaard BG; Palmieri L; Price JF; Ridker PM; Sun Q; Rosengren A; Roussel R; Sakurai M; Salomaa V; Schöttker B; Shaw JE; Strandberg TE; Sundström J; Tolonen H; Tverdal A; Verschuren WMM; Völzke H; Wagenknecht L; Wallace RB; Wannamethee SG; Wareham NJ; Wassertheil-Smoller S; Yamagishi K; Yeap BB; Harrison S; Inouye M; Griffin S; Butterworth AS; Wood AM; Thompson SG; Sattar N; Danesh J; Di Angelantonio E; Tipping RW; Russell S; Johansen M; Bancks MP; Mongraw-Chaffin M; Magliano D; Barr ELM; Zimmet PZ, 2023, 'Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation', The Lancet Diabetes and Endocrinology, 11, pp. 731 - 742, http://dx.doi.org/10.1016/S2213-8587(23)00223-1
    Journal articles | 2023
    Walker MR; Idorn M; Bennett A; Søgaard M; Salanti A; Ditlev SB; Barfod L, 2023, 'Characterization of SARS-CoV-2 humoral immune response in a subject with unique sampling: A case report', Immunity, Inflammation and Disease, 11, http://dx.doi.org/10.1002/iid3.910
    Journal articles | 2022
    Knudsen AS; Walker MR; Agullet JP; Björnsson KH; Bassi MR; Barfod L, 2022, 'Enhancing neutralization of Plasmodium falciparum using a novel monoclonal antibody against the rhoptry-associated membrane antigen', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-06921-1
    Journal articles | 2022
    Traeger MW; Guy R; Asselin J; Patel P; Carter A; Wright EJ; Grulich A; McManus H; Fairley CK; Chow EPF; McNulty A; Finlayson R; Bell C; Owen L; Marshall L; Russell D; O'Donnell D; Donovan B; Hellard ME; Stoové MA; Bastian L; Bateson D; Bowden S; Boyd M; Callander D; Cogle A; Costello J; Dimech W; Dittmer J; El-Hayek C; Ellard J; Franklin L; Hocking J; Kim J; McGill S; Nolan D; Pendle S; Polkinghorne V; Nguyen L; Nguyen T; O'Connor C; Reed P; Roth N; Ryder N; Selvey C; Vickers T; Walker M; Watchirs-Smith L; West M, 2022, 'Real-world trends in incidence of bacterial sexually transmissible infections among gay and bisexual men using HIV pre-exposure prophylaxis (PrEP) in Australia following nationwide PrEP implementation: an analysis of sentinel surveillance data', The Lancet Infectious Diseases, 22, pp. 1231 - 1241, http://dx.doi.org/10.1016/S1473-3099(22)00175-X
    Journal articles | 2022
    Walker MR; Barfod L, 2022, 'Production of PfEMP1-Specific Human Monoclonal Antibodies from Naturally Immune Individuals', , 2470, pp. 407 - 421, http://dx.doi.org/10.1007/978-1-0716-2189-9_30
    Journal articles | 2022
    Walker MR; Podlekareva D; Johnsen S; Leerhøy B; Fougeroux C; Søgaard M; Salanti A; Ditlev SB; Barfod L, 2022, 'SARS-CoV-2 RBD-Specific Antibodies Induced Early in the Pandemic by Natural Infection and Vaccination Display Cross-Variant Binding and Inhibition', Viruses, 14, http://dx.doi.org/10.3390/v14091861
    Journal articles | 2021
    Knudsen AS; Björnsson KH; Bassi MR; Walker MR; Kok A; Cristinoi B; Jensen AR; Barfod L, 2021, 'Strain-Dependent Inhibition of Erythrocyte Invasion by Monoclonal Antibodies Against Plasmodium falciparum CyRPA', Frontiers in Immunology, 12, http://dx.doi.org/10.3389/fimmu.2021.716305
    Journal articles | 2020
    Brasher NA; Eltahla AA; Underwood A; Boo I; Rizzetto S; Walker MR; Rodrigo C; Luciani F; Maher L; Drummer HE; Tedla N; Lloyd AR; Bull RA, 2020, 'B cell immunodominance in primary hepatitis C virus infection', Journal of Hepatology, 72, pp. 670 - 679, http://dx.doi.org/10.1016/j.jhep.2019.11.011
    Journal articles | 2020
    Mina M; Underwood A; Eltahla A; Wu BR; Walker MR; Bull RA; Lloyd AR, 2020, 'Anti-envelope antibody responses in highly exposed seronegative individuals may be associated with protection from HCV infection', Journal of Viral Hepatitis, 27, pp. 1012 - 1021, http://dx.doi.org/10.1111/jvh.13339
    Journal articles | 2020
    Walker MR; Eltahla AA; Mina MM; Li H; Lloyd AR; Bull RA, 2020, 'Envelope-specific IgG3 and IgG1 responses are associated with clearance of acute hepatitis C virus infection', Viruses, 12, pp. 75, http://dx.doi.org/10.3390/v12010075
    Journal articles | 2020
    Walker MR; Knudsen AS; Partey FD; Bassi MR; Frank AM; Castberg FC; Sarbah EW; Ofori MF; Hviid L; Barfod L, 2020, 'Acquisition and decay of IgM and IgG responses to merozoite antigens after Plasmodium falciparum malaria in Ghanaian children', PLoS ONE, 15, http://dx.doi.org/10.1371/journal.pone.0243943
    Journal articles | 2019
    Keck ZY; Pierce BG; Lau P; Lu J; Wang Y; Underwood A; Bull RA; Prentoe J; Velázquez-Moctezuma R; Walker MR; Luciani F; Guest JD; Fauvelle C; Baumert TF; Bukh J; Lloyd AR; Foung SKH, 2019, 'Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design', PLoS Pathogens, 15, pp. e1007772, http://dx.doi.org/10.1371/journal.ppat.1007772
    Journal articles | 2019
    Walker MR; Leung P; Eltahla AA; Underwood A; Abayasingam A; Brasher NA; Li H; Wu BR; Maher L; Luciani F; Lloyd AR; Bull RA, 2019, 'Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies', Scientific Reports, 9, pp. 13300, http://dx.doi.org/10.1038/s41598-019-49454-w
    Journal articles | 2019
    Wu BR; Eltahla AA; Keoshkerian E; Walker MR; Underwood A; Brasher NA; Agapiou D; Lloyd AR; Bull RA, 2019, 'A method for detecting hepatitis C envelope specific memory B cells from multiple genotypes using cocktail E2 tetramers', Journal of Immunological Methods, 472, pp. 65 - 74, http://dx.doi.org/10.1016/j.jim.2019.06.016
    Journal articles | 2018
    Underwood AP; Walker MR; Brasher NA; Eltahla AA; Maher L; Luciani F; Lloyd AR; Bull RA, 2018, 'Understanding the determinants of BnAb induction in acute HCV infection', Viruses, 10, pp. 659, http://dx.doi.org/10.3390/v10110659
    Journal articles | 2017
    Mutanga O; Walker M, 2017, 'Exploration of the academic lives of students with disabilities at South African universities: Lecturers' perspectives.', Afr J Disabil, 6, pp. 316, http://dx.doi.org/10.4102/ajod.v6i0.316
    Journal articles | 2017
    Rodrigo C; Walker MR; Leung P; Eltahla AA; Grebely J; Dore GJ; Applegate T; Page K; Dwivedi S; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Luciani F; Lloyd AR; Bull RA, 2017, 'Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection', Infection, Genetics and Evolution, 49, pp. 88 - 96, http://dx.doi.org/10.1016/j.meegid.2017.01.006
    Journal articles | 2016
    Bull RA; Eltahla AA; Rodrigo C; Koekkoek SM; Walker M; Pirozyan MR; Betz-Stablein B; Toepfer A; Laird M; Oh S; Heiner C; Maher L; Schinkel J; Lloyd AR; Luciani F; Rasoli Pirozyan M, 2016, 'A method for near full-length amplification and sequencing for six hepatitis C virus genotypes', BMC Genomics, 17, pp. 247, http://dx.doi.org/10.1186/s12864-016-2575-8
    Journal articles | 2016
    Walker MR; Li H; Teutsch S; Betz-Stablein B; Luciani F; Lloyd AR; Bull RA; Dolan K; Maher L, 2016, 'Incident hepatitis c virus genotype distribution and multiple infection in australian prisons', Journal of Clinical Microbiology, 54, pp. 1855 - 1861, http://dx.doi.org/10.1128/JCM.00287-16
    Journal articles | 2015
    Bull RA; Leung P; Gaudieri S; Deshpande P; Cameron B; Walker M; Chopra A; Lloyd AR; Luciani F; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Maher L, 2015, 'Transmitted/founder viruses rapidly escape from CD8+ T cell responses in acute hepatitis C virus infection', Journal of Virology, 89, pp. 5478 - 5490, http://dx.doi.org/10.1128/JVI.03717-14
    Journal articles | 2013
    Albrechtsen A; Grarup N; Li Y; Sparso T; Tian G; Cao H; Jiang T; Kim SY; Korneliussen T; Li Q; Nie C; Wu R; Skotte L; Morris AP; Ladenvall C; Cauchi S; Stancakova A; Andersen G; Astrup A; Banasik K; Bennett AJ; Bolund L; Charpentier G; Chen Y; Dekker JM; Doney ASF; Dorkhan M; Forsen T; Frayling TM; Groves CJ; Gui Y; Hallmans G; Hattersley AT; He K; Hitman GA; Holmkvist J; Huang S; Jiang H; Jin X; Justesen JM; Kristiansen K; Kuusisto J; Lajer M; Lantieri O; Li W; Liang H; Liao Q; Liu X; Ma T; Ma X; Manijak MP; Marre M; Mokrosinski J; Morris AD; Mu B; Nielsen AA; Nijpels G; Nilsson P; Palmer CNA; Rayner NW; Renstrom F; Ribel-Madsen R; Robertson N; Rolandsson O; Rossing P; Schwartz TW; Slagboom PE; Sterner M; Tang M; Tarnow L; Tuomi T; van't Riet E; van Leeuwen N; Varga TV; Vestmar MA; Walker M; Wang B; Wang Y; Wu H; Xi F; Yengo L; Yu C; Zhang X; Zhang J; Zhang Q; Zhang W; Zheng H; Zhou Y; Altshuler D; 't Hart LM; Franks PW; Balkau B; Froguel P; McCarthy MI; Laakso M; Groop L; Christensen C; Brandslund I; Lauritzen T; Witte DR; Linneberg A; Jorgensen T; Hansen T; Wang J; Nielsen R; Pedersen O, 2013, 'Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes', DIABETOLOGIA, 56, pp. 298 - 310, http://dx.doi.org/10.1007/s00125-012-2756-1