Back to
Professor Merlin Crossley
Deputy Vice-Chancellor

Professor Merlin Crossley

BSc Hons (Melb)

DPhil (Oxon)

Division of VC & President
Office of DVC Academic Quality

ABOUT ME

 

Biography

Merlin Crossley is Deputy Vice-Chancellor (Academic Quality) at UNSW and Professor of Molecular Biology. He has also worked or studied at the Universities of Melbourne, Oxford, Harvard and Sydney. He has been recognized by numerous awards, including a Rhodes Scholarship and the Australian Academy of Science's Gottschalk Medal. He has made significant contributions to academic administration, serving as Dean at UNSW since 2010, and previously having been Acting Deputy Vice-Chancellor Research at the University of Sydney from 2006 to 2008.

Education

  • BSc Hons (Melb) 1986
  • DPhil (Oxon) 1990

 

RESEARCH

 

Research Goals

  • Fundamental mechanisms of gene regulation
  • Epigenetics
  • Artificial DNA-binding proteins
  • Blood development
  • Haemophilia
  • Sickle cell anaemia and thalassaemia
  • Gene therapy via CRISPR gene editing

Research in Detail

We are interested in understanding the fundamental molecular mechanisms by which genes are controlled. Ultimately we hope to treat chronic diseases, such as sickle cell anaemia or diabetes, by turning on beneficial genes or repressing harmful genes.

Supervision Opportunities/Areas

Please contact my collaborator Kate.Quinlan@unsw.edu.au

 

TEACHING & OUTREACH

 

Courses I contribute to teaching

BIOC2201 Principles of Molecular Biology (Advanced)

BABS3121 Molecular Biology of Nucleic Acids

BABS3281 Molecular Genomics

 

Current professional affiliations and service positions

Board Member, Australian Science Media Centre (AusSMC) 2013–present

Trust Member, Australian Museum 2012–2020

Board Member, New South Innovations 2011–2015

Council Member, European Molecular Biology Laboratory Australia Council 2011–2015

Board Member, Sydney Institute of Marine Science 2010-17

Advisory Committee, Australian Astronomical Observatory, 2017-2019

Board Member, The Conversation (Chair of Editorial Board) 2019-present

Board Member, UNSW Press (NewSouth Publishing) 2015-present (Chair from 2019-present)

 
Phone
+61 2 9385 2800
E-mail
m.crossley@unsw.edu.au
Location
University of New South Wales Sydney NSW 2052 Dalton Building Room 201
  • Book Chapters | 2018
    Yik JJ; Crossley M; Quinlan KGR, 2018, 'Genome editing of erythroid cell culture model systems', in Erythropoiesis methods and protocols, Springer, pp. 245 - 257, http://dx.doi.org/10.1007/978-1-4939-7428-3_15
    Book Chapters | 2012
    Funnell AP; Crossley M, 2012, 'Homo‑ and Heterodimerization in Transcriptional Regulation (Ch. 7)', in Matthews JM (ed.), Protein Dimerization and Oligomerization in Biology, Springer Biomedical Sciences, pp. 105 - 121, http://dx.doi.org/10.1007/978-1-4614-3229-6-7
    Book Chapters | 2007
    Grant RP; Crossley M; Mackay JP, 2007, 'Zinc‐finger Genes', in , Wiley, http://dx.doi.org/10.1002/9780470015902.a0005047.pub2
    Book Chapters | 2004
    Verger A; Crossley M, 2004, 'The transcriptome', in Mammalian Genomics, pp. 118 - 151
    Book Chapters | 2002
    Mackay J; Crossley M, 2002, 'Zinc Fingers', in , Wiley, http://dx.doi.org/10.1002/0471203076.emm0414
  • Journal articles | 2022
    Crossley M; Christakopoulos GE; Weiss MJ, 2022, 'Effective therapies for sickle cell disease: are we there yet?', Trends in Genetics, 38, pp. 1284 - 1298, http://dx.doi.org/10.1016/j.tig.2022.07.003
    Journal articles | 2022
    Huang P; Peslak SA; Ren R; Khandros E; Qin K; Keller CA; Giardine B; Bell HW; Lan X; Sharma M; Horton JR; Abdulmalik O; Chou ST; Shi J; Crossley M; Hardison RC; Cheng X; Blobel GA, 2022, 'HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription', Nature Genetics, 54, pp. 1417 - 1426, http://dx.doi.org/10.1038/s41588-022-01152-6
    Journal articles | 2022
    Ly LC; Yang Y; Li F; Crossley M; Shi Y; Quinlan KGR, 2022, 'Protocols for protein-DNA binding analysis of a zinc finger transcription factor bound to its cognate promoter', STAR protocols, 3, pp. 101598, http://dx.doi.org/10.1016/j.xpro.2022.101598
    Journal articles | 2022
    Ravi NS; Wienert B; Wyman SK; Bell HW; George A; Mahalingam G; Vu JT; Prasad K; Bandlamudi BP; Devaraju N; Rajendiran V; Syedbasha N; Pai AA; Nakamura Y; Kurita R; Narayanasamy M; Balasubramanian P; Thangavel S; Marepally S; Velayudhan SR; Srivastava A; Dewitt MA; Crossley M; Corn JE; Mohankumar KM, 2022, 'Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin', eLife, 11, http://dx.doi.org/10.7554/ELIFE.65421
    Journal articles | 2022
    Topfer SK; Feng R; Huang P; Ly LC; Martyn GE; Blobel GA; Weiss MJ; Quinlan KGR; Crossley M, 2022, 'Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression', Blood, 139, pp. 2107 - 2118, http://dx.doi.org/10.1182/blood.2021014205
    Journal articles | 2021
    Doerfler PA; Feng R; Li Y; Palmer LE; Porter SN; Bell HW; Crossley M; Pruett-Miller SM; Cheng Y; Weiss MJ, 2021, 'Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin', Nature Genetics, 53, pp. 1177 - 1186, http://dx.doi.org/10.1038/s41588-021-00904-0
    Journal articles | 2021
    Lan X; Ren R; Feng R; Ly LC; Lan Y; Zhang Z; Aboreden N; Qin K; Horton JR; Grevet JD; Mayuranathan T; Abdulmalik O; Keller CA; Giardine B; Hardison RC; Crossley M; Weiss MJ; Cheng X; Shi J; Blobel GA, 2021, 'ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression', Molecular Cell, 81, pp. 239 - 254.e8, http://dx.doi.org/10.1016/j.molcel.2020.11.006
    Journal articles | 2021
    Yang Y; Ren R; Ly LC; Horton JR; Li F; Quinlan KGR; Crossley M; Shi Y; Cheng X, 2021, 'Structural basis for human ZBTB7A action at the fetal globin promoter', Cell Reports, 36, pp. 109759, http://dx.doi.org/10.1016/j.celrep.2021.109759
    Journal articles | 2020
    Dryzek JS; Nicol D; Niemeyer S; Pemberton S; Curato N; Bächtiger A; Batterham P; Bedsted B; Burall S; Burgess M; Burgio G; Castelfranchi Y; Chneiweiss H; Church G; Crossley M; de Vries J; Farooque M; Hammond M; He B; Mendonça R; Merchant J; Middleton A; Rasko JEJ; Van Hoyweghen I; Vergne A, 2020, 'Global citizen deliberation on genome editing', Science, 369, pp. 1435 - 1437, http://dx.doi.org/10.1126/SCIENCE.ABB5931
    Journal articles | 2020
    Knights AJ; Vohralik EJ; Houweling PJ; Stout ES; Norton LJ; Alexopoulos SJ; Yik JJ; Mat Jusoh H; Olzomer EM; Bell-Anderson KS; North KN; Hoehn KL; Crossley M; Quinlan KGR, 2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, 11, pp. 2922, http://dx.doi.org/10.1038/s41467-020-16758-9
    Journal articles | 2020
    Knights AJ; Yang L; Shah M; Norton LJ; Green GS; Stout ES; Vohralik EJ; Crossley M; Quinlan KGR, 2020, 'Krüppel-like factor 3 (klf3) suppresses nf-b-driven inflammation in mice', Journal of Biological Chemistry, 295, pp. 608 - 6091, http://dx.doi.org/10.1074/jbc.RA120.013114
    Journal articles | 2020
    Lan X; Ren R; Feng R; Ly LC; Lan Y; Zhang Z; Aboreden N; Qin K; Horton JR; Grevet JD; Mayuranathan T; Abdulmalik O; Keller CA; Giardine B; Hardison RC; Crossley M; Weiss MJ; Cheng X; Shi J; Blobel GA, 2020, 'ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression', Blood, 136, pp. 54 - 54, http://dx.doi.org/10.1182/blood-2020-137564
    Journal articles | 2020
    Yang L; Chen Z; Stout ES; Delerue F; Ittner LM; Wilkins MR; Quinlan KGR; Crossley M, 2020, 'Methylation of a CGATA element inhibits binding and regulation by GATA-1', Nature Communications, 11, pp. 2560, http://dx.doi.org/10.1038/s41467-020-16388-1
    Journal articles | 2019
    Doerfler P; Feng R; Porter S; Li Y; Crossley M; Cheng Y; Pruett-Miller S; Weiss M, 2019, 'FUNCTIONALLY DISTINCT UTILIZATION OF CIS-REGULATORY ELEMENTS IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN', EXPERIMENTAL HEMATOLOGY, 76, pp. S64 - S64, http://dx.doi.org/10.1016/j.exphem.2019.06.350
    Journal articles | 2019
    Martyn GE; Wienert B; Kurita R; Nakamura Y; Quinlan KGR; Crossley M, 2019, 'A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site', Blood, 133, pp. 852 - 856, http://dx.doi.org/10.1182/blood-2018-07-863951
    Journal articles | 2019
    Shah M; Funnell APW; Quinlan KGR; Crossley M, 2019, 'Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act', BioEssays, 41, pp. e1900041, http://dx.doi.org/10.1002/bies.201900041
    Journal articles | 2018
    Artuz CM; Knights AJ; Funnell APW; Gonda TJ; Ravid K; Pearson RCM; Quinlan KGR; Crossley M, 2018, 'Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules', Biotechnology Reports, 20, http://dx.doi.org/10.1016/j.btre.2018.e00285
    Journal articles | 2018
    Blobel GA; Crossley M, 2018, 'Charting a noncoding gene for g-globin activation', Blood, 132, pp. 1865 - 1867, http://dx.doi.org/10.1182/blood-2018-09-873620
    Journal articles | 2018
    Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KGR, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, 40, http://dx.doi.org/10.1002/bies.201800098
    Journal articles | 2018
    Martyn GE; Wienert B; Yang L; Shah M; Norton LJ; Burdach J; Kurita R; Nakamura Y; Pearson RCM; Funnell APW; Quinlan KGR; Crossley M, 2018, 'Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding', Nature Genetics, 50, pp. 498 - 503, http://dx.doi.org/10.1038/s41588-018-0085-0
    Journal articles | 2018
    Wienert B; Martyn GE; Funnell APW; Quinlan KGR; Crossley M, 2018, 'Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies', Trends in Genetics, 34, pp. 927 - 940, http://dx.doi.org/10.1016/j.tig.2018.09.004
    Journal articles | 2017
    Ilsley MD; Gillinder KR; Magor GW; Huang S; Bailey TL; Crossley M; Perkins AC, 2017, 'Krüppel-like factors compete for promoters and enhancers to fine-tune transcription', Nucleic Acids Research, 45, pp. 6572 - 6588, http://dx.doi.org/10.1093/nar/gkx441
    Journal articles | 2017
    Martyn GE; Quinlan KGR; Crossley M, 2017, 'The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1860, pp. 525 - 536, http://dx.doi.org/10.1016/j.bbagrm.2016.10.002
    Journal articles | 2017
    Nicol D; Eckstein L; Morrison M; Sherkow JS; Otlowski M; Whitton T; Bubela T; Burdon KP; Chalmers D; Chan S; Charlesworth J; Critchley C; Crossley M; de Lacey S; Dickinson JL; Hewitt AW; Kamens J; Kato K; Kleiderman E; Kodama S; Liddicoat J; Mackey DA; Newson AJ; Nielsen J; Wagner JK; McWhirter RE, 2017, 'Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic', Genome Medicine, 9, http://dx.doi.org/10.1186/s13073-017-0475-4
    Journal articles | 2017
    Norton LJ; Funnell APW; Burdach J; Wienert B; Kurita R; Nakamura Y; Philipsen S; Pearson RCM; Quinlan KGR; Crossley M, 2017, 'KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells', Blood Advances, 1, pp. 685 - 692, http://dx.doi.org/10.1182/bloodadvances.2016002303
    Journal articles | 2017
    Norton LJ; Hallal S; Stout ES; Funnell APW; Pearson RCM; Crossley M; Quinlan KGR, 2017, 'Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-03289-5
    Journal articles | 2017
    Wienert B; Martyn GE; Kurita R; Nakamura Y; Quinlan KGR; Crossley M, 2017, 'KLF1 drives the expression of fetal hemoglobin in British HPFH', Blood, 130, pp. 803 - 807, http://dx.doi.org/10.1182/blood-2017-02-767400
    Journal articles | 2016
    Berber S; Wood M; Llamosas E; Thaivalappil P; Lee K; Liao BM; Chew YL; Rhodes A; Yucel D; Crossley M; Nicholas HR, 2016, 'Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19582
    Journal articles | 2016
    Knights AJ; Yik JJ; Jusoh HM; Norton LJ; Funnell APW; Pearson RCM; Bell-Anderson KS; Crossley M; Quinlan KGR, 2016, 'Krüppel-like factor 3 (KLF3/BKLF) is required for widespread repression of the inflammatory modulator galectin-3 (Lgals3)', Journal of Biological Chemistry, 291, pp. 16048 - 16058, http://dx.doi.org/10.1074/jbc.M116.715748
    Journal articles | 2016
    Masuda T; Wang X; Maeda M; Canver MC; Sher F; Funnell APW; Fisher C; Suciu M; Martyn GE; Norton LJ; Zhu C; Kurita R; Nakamura Y; Xu J; Higgs DR; Crossley M; Bauer DE; Orkin SH; Kharchenko PV; Maeda T, 2016, 'Gene regulation: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin', Science, 351, pp. 285 - 289, http://dx.doi.org/10.1126/science.aad3312
    Journal articles | 2016
    Perkins A; Xu X; Higgs DR; Patrinos GP; Arnaud L; Bieker JJ; Philipsen S; Anstee D; Bodine D; Borg J; Crossley M; Dun L; Felice AE; Frayne J; Gallagher P; Gillinder K; Grech L; Lloyd JA; Moi P; Shen JCK; Siatecka M; Singleton B; Tallack M; Townes T; Thein SL; Viprakasit V, 2016, 'Kruppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants', BLOOD, 127, pp. 1856 - 1862, http://dx.doi.org/10.1182/blood-2016-01-694331
    Journal articles | 2015
    Dewi V; Kwok A; Lee S; Lee MM; Tan YM; Nicholas HR; Isono KI; Wienert B; Mak KS; Knights AJ; Quinlan KGR; Cordwell SJ; Funnell APW; Pearson RCM; Crossley M, 2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, 290, pp. 8591 - 8605, http://dx.doi.org/10.1074/jbc.M115.638338
    Journal articles | 2015
    Lim WF; Burdach J; Funnell APW; Pearson RCM; Quinlan KGR; Crossley M, 2015, 'Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain', Nucleic Acids Research, 44, pp. 3118 - 3130, http://dx.doi.org/10.1093/nar/gkv1380
    Journal articles | 2015
    Wienert B; Funnell APW; Norton LJ; Pearson RCM; Wilkinson-White LE; Lester K; Vadolas J; Porteus MH; Matthews JM; Quinlan KGR; Crossley M, 2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin', Nature Communications, 6, pp. 7085, http://dx.doi.org/10.1038/ncomms8085
    Journal articles | 2014
    Ballester B; Medina-Rivera A; Schmidt D; Gonzàlez-Porta M; Carlucci M; Chen X; Chessman K; Faure AJ; Funnell APW; Goncalves A; Kutter C; Lukk M; Menon S; McLaren WM; Stefflova K; Watt S; Weirauch MT; Crossley M; Marioni JC; Odom DT; Flicek P; Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, 3, pp. 1 - 29, http://dx.doi.org/10.7554/eLife.02626
    Journal articles | 2014
    Ballester B; Medina-Rivera A; Schmidt D; Gonzàlez-Porta M; Carlucci M; Chen X; Chessman K; Faure AJ; Funnell APW; Goncalves A; Kutter C; Lukk M; Menon S; McLaren WM; Stefflova K; Watt S; Weirauch MT; Crossley M; Marioni JC; Odom DT; Flicek P; Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, 3, pp. e02626, http://dx.doi.org/10.7554/eLife.02626
    Journal articles | 2014
    Burdach J; Funnell APW; Mak KS; Artuz CM; Wienert B; Lim WF; Tan LY; Pearson RCM; Crossley M, 2014, 'Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor', Nucleic Acids Research, 42, pp. 276 - 289, http://dx.doi.org/10.1093/nar/gkt895
    Journal articles | 2014
    Clifton MK; Westman BJ; Thong SY; O'Connell MR; Webster MW; Shepherd NE; Quinlan KG; Crossley M; Blobel GA; Mackay JP, 2014, 'The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0106011
    Journal articles | 2014
    Funnell APW; Crossley M, 2014, 'Hemophilia B Leyden and once mysterious cis-regulatory mutations', Trends in Genetics, 30, pp. 18 - 23, http://dx.doi.org/10.1016/j.tig.2013.09.007
    Journal articles | 2014
    Funnell APW; Vernimmen D; Lim WF; Mak KS; Wienert B; Martyn GE; Artuz CM; Burdach J; Quinlan KGR; Higgs DR; Whitelaw E; Pearson RCM; Crossley M, 2014, 'Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells', BMC Molecular Biology, 15, http://dx.doi.org/10.1186/1471-2199-15-8
    Journal articles | 2014
    Knights AJ; Funnell AP; Pearson RC; Crossley M; Bell-Anderson KS, 2014, 'Adipokines and insulin action: A sensitive issue', Adipocyte, 3, pp. 88 - 96, http://dx.doi.org/10.4161/adip.27552
    Journal articles | 2014
    Mak KS; Burdach J; Norton LJ; Pearson RCM; Crossley M; Funnell APW, 2014, 'Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor', Genome Biology, 15, http://dx.doi.org/10.1186/gb-2014-15-4-r58
    Journal articles | 2014
    Reid A; Yücel D; Wood M; Llamosas E; Kant S; Crossley M; Nicholas H, 2014, 'The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan', Experimental Gerontology, 60, pp. 153 - 165, http://dx.doi.org/10.1016/j.exger.2014.09.022
    Journal articles | 2014
    Yücel D; Hoe M; Llamosas E; Kant S; Jamieson C; Young PA; Crossley M; Nicholas HR, 2014, 'SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans', Developmental Biology, 392, pp. 266 - 282, http://dx.doi.org/10.1016/j.ydbio.2014.05.018
    Journal articles | 2013
    Bell-Anderson KS; Funnell AP; Williams H; Mat Jusoh H; Scully T; Lim WF; Burdach J; Mak KS; Knights AJ; Hoy AJ; Nicholas HR; Sainsbury A; Turner N; Pearson R; Crossley M, 2013, 'Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).', Diabetes, 62, pp. 2728 - 2737, http://dx.doi.org/10.2337/db12-1745
    Journal articles | 2013
    Berber S; Llamosas E; Thaivalappil P; Boag PR; Crossley M; Nicholas HR, 2013, 'Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans', Developmental Dynamics, 242, pp. 1250 - 1261, http://dx.doi.org/10.1002/dvdy.24023
    Journal articles | 2013
    Funnell AP; Wilson M; Ballester B; Mak KS; Burdach J; Magan N; Pearson RC; Lemaigre F; Stowell K; Odom D; Flicek P; Crossley M, 2013, 'A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden', American Journal of Human Genetics, 92, pp. 460 - 467, http://dx.doi.org/10.1016/j.ajhg.2013.02.003
    Journal articles | 2013
    Funnell APW; Mak KS; Twine NA; Pelka GJ; Norton LJ; Radziewic T; Power M; Wilkins MR; Bell-Anderson KS; Fraser ST; Perkins AC; Tam PP; Pearson RCM; Crossley M, 2013, 'Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing', Molecular and Cellular Biology, 33, pp. 2976 - 2987, http://dx.doi.org/10.1128/MCB.00074-13
    Journal articles | 2013
    Kelsey L; Flenniken AM; Qu D; Funnell APW; Pearson R; Zhou YQ; Voronina I; Berberovic Z; Wood G; Newbigging S; Weiss ES; Wong M; Quach I; Yeh SYS; Deshwar AR; Scott IC; McKerlie C; Henkelman M; Backx P; Simpson J; Osborne L; Rossant J; Crossley M; Bruneau B; Adamson SL, 2013, 'ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003612
    Journal articles | 2013
    Mackay JP; Segal DJ; Crossley M, 2013, 'Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?', Trends in Biochemical Sciences, 38, pp. 421 - 422, http://dx.doi.org/10.1016/j.tibs.2013.06.005
    Journal articles | 2013
    Vandevenne M; Jacques DA; Artuz C; Nguyen CD; Kwan AH; Segal DJ; Matthews JM; Crossley M; Guss JM; Mackay JP, 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', J Biol Chem, 288, pp. 10616 - 10627, http://dx.doi.org/10.1074/jbc.M112.441451
    Journal articles | 2012
    Bendak K; Loughlin FE; Cheung V; O'Connell MR; Crossley M; MacKay JP, 2012, 'A rapid method for assessing the RNA-binding potential of a protein', Nucleic Acids Research, 40, http://dx.doi.org/10.1093/nar/gks285
    Journal articles | 2012
    Burdach J; O'Connell M; Mackay JP; Crossley M, 2012, 'Two-timing zinc finger transcription factors liaising with RNA', Trends in Biochemical Sciences, 37, pp. 199 - 205, http://dx.doi.org/10.1016/j.tibs.2012.02.001
    Journal articles | 2012
    Crossley M; Funnell AP, 2012, 'Homo- and heterodimerization in transcriptional regulation.', Advances in Experimental Medicine and Biology, 747, pp. 105 - 121, http://dx.doi.org/10.1007/978-1-4614-3229-6_7
    Journal articles | 2012
    Funnell AP; Norton LJ; Mak KS; Burdach J; Artuz CM; Twine NA; Wilkins MR; Power C; Hung TT; Perdomo JS; Bell-Anderson K; Orkin SH; Pearson RC; Crossley M, 2012, 'The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo', Molecular and Cellular Biology, 32, pp. 3281 - 3292, http://dx.doi.org/10.1128/MCB.00173-12
    Journal articles | 2012
    Knights A; Funnell AP; Crossley M; Pearson RC, 2012, 'Holding tight: cell junctions and cancer spread', Trends in Cancer Research, 8, pp. 61 - 69, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582402/
    Journal articles | 2012
    Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012
    Journal articles | 2011
    Crossley M; Norton LJ; Funnell AP; Pearson R, 2011, 'Cellular reprogramming toward the erythroid lineage', International Journal of Cell Biology, pp. Art. No. 501464, http://dx.doi.org/10.1155/2011/501464
    Journal articles | 2011
    Jack BH; Pearson RC; Crossley M, 2011, 'C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis', International Journal of Biochemistry and Cell Biology, 43, pp. 693 - 696, http://dx.doi.org/10.1016/j.biocel.2011.01.017
    Journal articles | 2011
    Mak KS; Funnell AP; Pearson RC; Crossley M, 2011, 'PU.1 and haematopoietic cell fate: Dosage matters', International Journal of Cell Biology, pp. Art. No. 808524, http://dx.doi.org/10.1155/2011/808524
    Journal articles | 2011
    Nunez N; Clifton MM; Funnell AP; Artuz CM; Hallal S; Quinlan KG; Font J; Vandevenne M; Setiyaputra S; Pearson RC; Mackay JP; Crossley M, 2011, 'The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain', The Journal of Biological Chemistry, 286, pp. 38190 - 38201, http://dx.doi.org/10.1074/jbc.M111.301234
    Journal articles | 2011
    Pearson RC; Funnell AP; Crossley M, 2011, 'The mammalian transcription factor Krüppel-like Factor 3 (KLF3/BKLF)', IUBMB Life, 63, pp. 86 - 93, http://dx.doi.org/10.1002/iub.422
    Journal articles | 2011
    Turchinovich G; Vu TT; Frommer F; Kranich J; Schmid S; Alles M; Loubert JB; Goulet JP; Zimber-Strobl U; Schneider P; Bachl J; Pearson RC; Crossley M; Agenes F; Kirberg J, 2011, 'Programming of marginal zone B cell fate by basic krüppel-like factor (BKLF/KLF3)', Blood, 117, pp. 3780 - 3792, http://dx.doi.org/10.1182/blood-2010-09-308742
    Journal articles | 2011
    Vu TT; Gatto D; Turner V; Funnell AP; Mak KS; Norton LJ; Kaplan W; Cowley MJ; Agenes F; Kirberg J; Brink R; Pearson RC; Crossley M, 2011, 'Impaired B cell development in the absence of Kruppel-like Factor 3.', Journal of Immunology, 187, pp. 5032 - 5042, http://dx.doi.org/10.4049/jimmunol.1101450
    Journal articles | 2011
    Wilkinson-White L; Gamsjaeger R; Dastmalchi S; Weinert B; Stokes P; Crossley M; Mackay JP; Matthews JM, 2011, 'Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 14443 - 14448, http://dx.doi.org/10.1073/pnas.1105898108
    Journal articles | 2011
    Wissmueller S; Font J; Liew CW; Cram ED; Schroeder T; Turner J; Crossley M; Mackay JP; Matthews JM, 2011, 'Protein-protein interactions: Analysis of a false positive GST pulldown result', Proteins - Structure Function and Bioinformatics, 79, pp. 2365 - 2371, http://dx.doi.org/10.1002/prot.23068
    Journal articles | 2010
    Jack B; Crossley M, 2010, 'GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control', The Journal of Biological Chemistry, 285, pp. 32405 - 32414, http://dx.doi.org/10.1074/jbc.M110.141317
    Journal articles | 2010
    Pearson RC; Crossley M, 2010, 'KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding site', Molecular and Cellular Biology, 30, pp. 3430 - 3443, http://dx.doi.org/10.1128/MCB.00302-10
    Journal articles | 2009
    Natalie Winteringham L; Endersby R; Beaumont J; Lalonde J-P; Crossley M; Klinken SP, 2009, 'Hls5, a Novel Ubiquitin E3 Ligase, Modulates Levels of Sumoylated GATA-1.', Blood, 114, pp. 253 - 253, http://dx.doi.org/10.1182/blood.v114.22.253.253
    Journal articles | 2007
    Funnell APW; Keys J; Tallack M; Hodge D; Perkins AC; Crossley M, 2007, 'Identification of a novel, erythroid BKLF promoter', Blood Cells, Molecules, and Diseases, 38, pp. 139 - 140, http://dx.doi.org/10.1016/j.bcmd.2006.10.049
    Journal articles | 2007
    Pearson R; Funnel APW; Kwok A; Keys J; Tallack M; Hodge D; Perkins AC; Crossley M, 2007, 'The regulation of gene repression by BKLF', BLOOD CELLS MOLECULES AND DISEASES, 38, pp. 133 - 134, http://dx.doi.org/10.1016/j.bcmd.2006.10.035
    Journal articles | 2005
    Marreiros A; Dudgeon K; Dao V; Grimm MO; Czolij R; Crossley M; Jackson P, 2005, '884KAI1 promoter activity is dependent on P53, junb and AP2: Evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells', European Urology Supplements, 4, pp. 223 - 223, http://dx.doi.org/10.1016/s1569-9056(05)80888-7
    Journal articles | 2004
    Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Erratum: Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (Molecular and Cellular Biology (2003) 23, 10 (3427-3441))', Molecular and Cellular Biology, 24, pp. 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004
    Journal articles | 2004
    Luo Q; Ma X; Wahl SM; Bieker JJ; Crossley M; Montaner LJ, 2004, 'Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages', Journal of Biological Chemistry, 279, pp. 18451 - 18456, http://dx.doi.org/10.1074/jbc.M400320200
    Journal articles | 2004
    Simpson RJY; Lee SHY; Bartle N; Sum EY; Visvader JE; Matthews JM; Mackay JP; Crossley M, 2004, 'Classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3', Journal of Biological Chemistry, 279, pp. 39789 - 39797, http://dx.doi.org/10.1074/jbc.M404130200
    Journal articles | 2004
    Verger A; Crossley M, 2004, 'Chromatin modifiers in transcription and DNA repair', Cellular and Molecular Life Sciences, 61, pp. 2154 - 2162, http://dx.doi.org/10.1007/s00018-004-4176-y
    Journal articles | 2003
    Crossley M, 2003, 'Transcriptional Treats', BioEssays, 25, pp. 190 - 192, http://dx.doi.org/10.1002/bies.10235
    Journal articles | 2003
    Kwan AHY; Czolij R; Mackay JP; Crossley M, 2003, 'Pentaprobe: a comprehensive sequence for the one-step detection of DNA-binding activities.', Nucleic acids research, 31, http://dx.doi.org/10.1093/nar/gng124
    Journal articles | 2003
    Kwan AHY; Gell DA; Verger A; Crossley M; Matthews JM; Mackay JP, 2003, 'Engineering a protein scaffold from a PHD finger', Structure, 11, pp. 803 - 813, http://dx.doi.org/10.1016/S0969-2126(03)00122-9
    Journal articles | 2003
    Pizzuti A; Sarkozy A; Newton AL; Conti E; Flex E; Digilio MC; Amati F; Gianni D; Tandoi C; Marino B; Crossley M; Dallapiccola B, 2003, 'Erratum: Mutations of ZFPM2/FOG2 Gene in Sporadic Cases of Tetralogy of Fallot (Human Mutation (2003) 22 (372-377))', Human Mutation, 22, pp. 494 - 495, http://dx.doi.org/10.1002/humu.10308
    Journal articles | 2003
    Pizzuti A; Sarkozy A; Newton AL; Conti E; Flex E; Digilio MC; Amati F; Gianni D; Tandoi C; Marino B; Crossley M; Dallapiccola B, 2003, 'Mutations of ZFPM2/FOG2 Gene in Sporadic Cases of Tetralogy of Fallot', Human Mutation, 22, pp. 372 - 377, http://dx.doi.org/10.1002/humu.10261
    Journal articles | 2003
    Simpson RJY; Cram ED; Czolij R; Matthews JM; Crossley M; Mackay JP, 2003, 'CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions', Journal of Biological Chemistry, 278, pp. 28011 - 28018, http://dx.doi.org/10.1074/jbc.M211146200
    Journal articles | 2003
    Turner J; Nicholas H; Bishop D; Matthews JM; Crossley M, 2003, 'The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2', Journal of Biological Chemistry, 278, pp. 12786 - 12795, http://dx.doi.org/10.1074/jbc.M300587200
    Journal articles | 2002
    Kowalski K; Liew CK; Matthews JM; Gell DA; Crossley M; Mackay JP, 2002, 'Characterization of the conserved interaction between GATA and FOG family proteins', Journal of Biological Chemistry, 277, pp. 35720 - 35729, http://dx.doi.org/10.1074/jbc.M204663200
    Journal articles | 2002
    Perdomo JS, 2002, 'The Ikaros family protein Eos associates with C-terminal-binding protein corepressors', European Journal of Biochemistry, 269, pp. 5885 - 5892, http://dx.doi.org/10.1046/j.1432-1033.2002.03313.x
    Journal articles | 2002
    Sharpe BK; Matthews JM; Kwan AHY; Newton A; Gell DA; Crossley M; Mackay JP, 2002, 'A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution', Structure, 10, pp. 639 - 648, http://dx.doi.org/10.1016/S0969-2126(02)00757-8
    Journal articles | 2001
    Crossley M, 2001, 'Transcription of the genome: Don't read it all at once', Genome Biology, 2
    Journal articles | 2001
    Eisbacher M; Newton A; Holmes ML; Khachigian LM; Crossley M; Chong BH, 2001, 'The protein-protein interaction between FLI-1 and GATA-1 is crucial for expression of the megakaryocyte-specific gene Glycoprotein IX.', BLOOD, 98, pp. 286A - 286A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2001
    Mehaffey MG; Newton AL; Gandhi MJ; Crossley M; Drachman JG, 2001, 'X-linked thrombocytopenia caused by a novel mutation of GATA-1', Blood, 98, pp. 2681 - 2688, http://dx.doi.org/10.1182/blood.V98.9.2681
    Journal articles | 2001
    Newton A; Mackay J; Crossley M, 2001, 'The N-terminal Zinc Finger of the Erythroid Transcription Factor GATA-1 Binds GATC Motifs in DNA', Journal of Biological Chemistry, 276, pp. 35794 - 35801, http://dx.doi.org/10.1074/jbc.M106256200
    Journal articles | 2001
    Palmer S; Brouillet JP; Kilbey A; Fulton R; Walker M; Crossley M; Bartholomew C, 2001, 'Evi-1 Transforming and Repressor Activities are Mediated by CtBP Co-repressor Proteins', Journal of Biological Chemistry, 276, pp. 25834 - 25840, http://dx.doi.org/10.1074/jbc.M102343200
    Journal articles | 2001
    Sathasivam P; Bailey AM; Crossley M; Byrne JA, 2001, 'The role of the coiled-coil motif in interactions mediated by TPD52', Biochemical and Biophysical Research Communications, 288, pp. 56 - 61, http://dx.doi.org/10.1006/bbrc.2001.5721
    Journal articles | 2001
    Schuierer M; Hilger-Eversheim K; Dobner T; Bosserhoff AK; Moser M; Turner J; Crossley M; Buettner R, 2001, 'Induction of AP-2α Expression by Adenoviral Infection Involves Inactivation of the AP-2rep Transcriptional Corepressor CtBP1', Journal of Biological Chemistry, 276, pp. 27944 - 27949, http://dx.doi.org/10.1074/jbc.M100070200
    Journal articles | 2001
    Turner J; Crossley M, 2001, 'The CtBP family: Enigmatic and enzymatic transcriptional co-repressors', BioEssays, 23, pp. 683 - 690, http://dx.doi.org/10.1002/bies.1097
    Journal articles | 2000
    Chu Kong Liew ; Kowalski K; Fox AH; Newton A; Sharpe BK; Crossley M; Mackay JP, 2000, 'Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions', Structure, 8, pp. 1157 - 1166, http://dx.doi.org/10.1016/S0969-2126(00)00527-X
    Journal articles | 2000
    Matthews JM; Kowalski K; Liew CK; Sharpe BK; Fox AH; Crossley M; Mackay JP, 2000, 'A class of zinc fingers involved in protein-protein interactions', European Journal of Biochemistry, 267, pp. 1030 - 1038, http://dx.doi.org/10.1046/j.1432-1327.2000.01095.x
    Journal articles | 2000
    Newton AL; Sharped BK; Kwan A; Mackay JP; Crossley M, 2000, 'The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules', Journal of Biological Chemistry, 275, pp. 15128 - 15134, http://dx.doi.org/10.1074/jbc.M910396199
    Journal articles | 2000
    Perdomo J; Holmes ML; Chong BH; Crossley M, 2000, 'Eos and Pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities', The Journal of Biological Chemistry, 275, pp. 38347 - 38354, http://dx.doi.org/10.1074/jbc.M005457200
    Journal articles | 2000
    Van Vliet J; Turner J; Crossley M, 2000, 'Human Kruppel-like Factor 8: A CACCC-box binding protein that associates with CtBP and represses transcription', Nucleic Acids Research, 28, pp. 1955 - 1962, http://dx.doi.org/10.1093/nar/28.9.1955
    Journal articles | 1999
    Fox A; Liew C; Holmes ML; Kowalski K; Mackay J; Crossley M, 1999, 'Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers', European Molecular Biology Organization, 18, pp. 2812 - 2822, http://dx.doi.org/10.1093/emboj/18.10.2812
    Journal articles | 1999
    Fox AH; Holmes M; MacKay J; Crossley M, 1999, 'The activity of FOG-1 is potentiated by its ability to contact GATA-1 through multiple zinc fingers', Biochemical Society Transactions, 27, pp. A99 - A99, http://dx.doi.org/10.1042/bst027a099c
    Journal articles | 1999
    Holmes ML; Turner J; Fox A; Chisholm OT; Crossley M; Chong BH, 1999, 'hFOG-2, a novel zinc finger protein, binds the corepressor mCtBP2 and modulates GATAmediated activation', The Journal of Biological Chemistry, 274, pp. 23491 - 23498, http://dx.doi.org/10.1074/jbc.274.33.23491
    Journal articles | 1999
    Kowalski K; Czolij R; King GF; Crossley M; Mackay JP, 1999, 'The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG', Journal of Biomolecular NMR, 13, pp. 249 - 262, http://dx.doi.org/10.1023/A:1008309602929
    Journal articles | 1999
    Turner J; Crossley M, 1999, 'Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors', International Journal of Biochemistry and Cell Biology, 31, pp. 1169 - 1174, http://dx.doi.org/10.1016/S1357-2725(99)00067-9
    Journal articles | 1999
    Turner J; Crossley M, 1999, 'Mammalian Kruppel-like transcription factors: More than just a pretty finger', Trends in Biochemical Sciences, 24, pp. 236 - 240, http://dx.doi.org/10.1016/S0968-0004(99)01406-1
    Journal articles | 1998
    Bradbury RA; Sunn KL; Crossley M; Bai M; Brown EM; Delbridge L; Conigrave AD, 1998, 'Expression of the parathyroid Ca2+-sensing receptor in cytotrophoblasts from human term placenta', Journal of Endocrinology, 156, pp. 425 - 430, http://dx.doi.org/10.1677/joe.0.1560425
    Journal articles | 1998
    Fox AH; Kowalski K; King GF; Mackay JP; Crossley M, 1998, 'Key residues characteristic of GATA N-fingers are recognized by FOG', Journal of Biological Chemistry, 273, pp. 33595 - 33603, http://dx.doi.org/10.1074/jbc.273.50.33595
    Journal articles | 1998
    Mackay JP; Crossley M, 1998, 'Zinc fingers are sticking together', Trends in Biochemical Sciences, 23, pp. 1 - 4, http://dx.doi.org/10.1016/S0968-0004(97)01168-7
    Journal articles | 1998
    Mackay JP; Kowalski K; Fox AH; Czolij R; King GF; Crossley M, 1998, 'Involvement of the N-finger in the self-association of GATA-1', Journal of Biological Chemistry, 273, pp. 30560 - 30567, http://dx.doi.org/10.1074/jbc.273.46.30560
    Journal articles | 1998
    Spadaccini A; Tilbrook PA; Sarna MK; Crossley M; Bieke JJ; Klinken SP, 1998, 'Transcription factor erythroid Kruppel-like factor (ELKF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation', Journal of Biological Chemistry, 273, pp. 23793 - 23798, http://dx.doi.org/10.1074/jbc.273.37.23793
    Journal articles | 1998
    Turner J; Crossley M, 1998, 'Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators', EMBO Journal, 17, pp. 5129 - 5140, http://dx.doi.org/10.1093/emboj/17.17.5129
    Journal articles | 1997
    Tsang AP; Visvader JE; Turner CA; Fujiwara Y; Yu C; Weiss MJ; Crossley M; Orkin SH, 1997, 'FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation', Cell, 90, pp. 109 - 119, http://dx.doi.org/10.1016/S0092-8674(00)80318-9
    Journal articles | 1996
    Crossley M; Whitelaw E; Perkins A; Williams G; Fujiwara Y; Orkin SH, 1996, 'Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells', Molecular and Cellular Biology, 16, pp. 1695 - 1705, http://dx.doi.org/10.1128/MCB.16.4.1695
    Journal articles | 1995
    Crossley M; Merika M; Orkin SH, 1995, 'Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains', Molecular and Cellular Biology, 15, pp. 2448 - 2456, http://dx.doi.org/10.1128/MCB.15.5.2448
    Journal articles | 1995
    Visvader JE; Crossley M; Hill J; Orkin SH; Adams JM, 1995, 'The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line', Molecular and Cellular Biology, 15, pp. 634 - 641, http://dx.doi.org/10.1128/mcb.15.2.634
    Journal articles | 1994
    Crossley M; Orkin SH, 1994, 'Phosphorylation of the erythroid transcription factor GATA-1', Journal of Biological Chemistry, 269, pp. 16589 - 16596
    Journal articles | 1994
    Crossley M; Tsang AP; Bieker JJ; Orkin SH, 1994, 'Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1', Journal of Biological Chemistry, 269, pp. 15440 - 15444
    Journal articles | 1993
    Crossley M; Orkin SH, 1993, 'Regulation of the β-globin locus', Current Opinion in Genetics and Development, 3, pp. 232 - 237, http://dx.doi.org/10.1016/0959-437X(93)90028-N
    Journal articles | 1992
    Crossley M; Ludwig M; Stowell KM; De Vos P; Olek K; Brownlee GG, 1992, 'Recovery from hemophilia B Leyden: An androgen responsive element in the factor IX promoter', Science, 257, pp. 377 - 379, http://dx.doi.org/10.1126/science.1631558
    Journal articles | 1990
    Crossley M; Brownlee GG, 1990, 'Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B', Nature, 345, pp. 444 - 446, http://dx.doi.org/10.1038/345444a0
    Journal articles | 1990
    Crossley M; Winship PR; Austen DEG; Rizza CR; Brownlee GG, 1990, 'A less severe form of haemophilia B leyden', Nucleic Acids Research, 18, pp. 4633, http://dx.doi.org/10.1093/nar/18.15.4633
    Journal articles | 1990
    Pang CP; Crossley M; Kent G; Brownlee GG, 1990, 'Comparative sequence analysis of mammalian factor IX promoters', Nucleic Acids Research, 18, pp. 6731 - 6732, http://dx.doi.org/10.1093/nar/18.22.6731
    Journal articles | 1989
    CROSSLEY PM; WINSHIP PR; BLACK A; RIZZA CR; BROWNLEE GG, 1989, 'UNUSUAL CASE OF HAEMOPHILIA-B', LANCET, 1, pp. 960 - 960, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989U400800034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
  • Preprints | 2020
    Lan X; Ren R; Feng R; Ly LC; Lan Y; Zhang Z; Aboreden N; Qin K; Horton JR; Grevet JD; Mayuranathan T; Abdulmalik O; Keller CA; Giardine B; Hardison RC; Crossley M; Weiss MJ; Cheng X; Shi J; Blobel GA, 2020, ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression, , http://dx.doi.org/10.1101/2020.08.31.274324
    Other | 2019
    Fan Y; Crossley M; Johnston E, 2019, Male teachers are most likely to rate highly in university student feedback, , https://theconversation.com/male-teachers-are-most-likely-to-rate-highly-in-university-student-feedback-111741
    Conference Papers | 2016
    Ilsley M; Gillinder KR; Magor G; Crossley M; Perkins AC, 2016, 'Fine-Tuning Erythropoiesis By Competition Between Kruppel-like Factors for Promoters and Enhancers', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, presented at 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), CA, San Diego, 03 December 2016 - 06 December 2016, http://dx.doi.org/10.1182/blood.V128.22.1036.1036
    Other | 2016
    Mak KS; Burdach J; Norton LJ; Pearson RCM; Crossley M; Funnell APW, 2016, Erratum to: Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor [Genome Biology, 15 (2014) R58], , http://dx.doi.org/10.1186/s13059-016-0977-1
    Conference Abstracts | 2015
    Masuda T; Wang X; Maeda M; Canver MC; Sher F; Funnell APW; Fisher C; Suciu M; Martyn GE; Norton LJ; Zhu R; Kurita R; Nakamura Y; Xu J; Higgs DR; Crossley M; Bauer DE; Orkin SH; Kharchenko PV; Maeda T, 2015, 'The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, Vol. 126, presented at 57th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 05 December 2015 - 08 December 2015, http://dx.doi.org/10.1182/blood.V126.23.2.2
    Conference Papers | 2012
    Yucel D; Llamosas E; Crossley M; Nicholas H, 2012, 'The regulation of C-terminal Binding Protein (CtBP) by a putative chromatin modifier', in JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE BV, TURKEY, Erciyes Univ, Kayseri, pp. 13 - 13, presented at Eurobiotech Agriculture Symposium, TURKEY, Erciyes Univ, Kayseri, 12 April 2012 - 14 April 2012, http://dx.doi.org/10.1016/j.jbiotec.2012.07.014
    Conference Papers | 2003
    Crossley M, 2003, 'Unscrambling the genome', in Genome Biology, http://dx.doi.org/10.1186/gb-2003-4-5-320
    Conference Papers | 2002
    Crossley M, 2002, 'Genome packaging and expression', in Genome Biology
    Conference Papers | 2002
    Turner J; Holmes M; Czolij R; Gaensler K; Yang HD; Fujiwara Y; Chong B; Koh P; Perkins A; Orkin S; Crossley M, 2002, 'Basic Kruppel-like factor recruits multiple co-repressors to silence gene expression.', in BLOOD CELLS MOLECULES AND DISEASES, ACADEMIC PRESS INC ELSEVIER SCIENCE, ENGLAND, OXFORD, pp. 135 - 136, presented at 13th Conference on Hemoglobin Switching, ENGLAND, OXFORD, 26 September 2002 - 30 September 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184101400050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

  • National Health and Medical Research Council Ideas Grant GNT2020861 New approaches to treating hemologinopathies M. Crossley and Kate Quinlan, 2023-27 $1,508,780
  • National Health and Medical Research Council Project APP1164920 Silencing silencers to boost fetal globin production and treat beta-hemoglobinopathies M.Crossley, Kate Quinlan, and Mitch Weiss, 2019-2022, $560,394
  • National Health and Medical Research Council Project APP1098391 Editing beneficial single nucleotide polymorphisms into the genome: A new approach to genetic disease M.Crossley, 2016-8, $646,979
  • National Health and Medical Research Council Project APP1025877 Transcriptional regulation of globin genes M. Crossley and R. Pearson, 2012-14, $636,325
  • National Health and Medical Research Council Project APP1025873 Transcriptional control of megakaryopoiesis M. Crossley, K. Ravid, T. Gonda and R. Pearson, 2012-14, $651,010
  • National Health and Medical Research Council Project APP1009172 Identifying regulators of the DNA damage response and tumourigenesis using C.elegans H. Nicholas and M. Crossley, 2011-13, $496,706
  • National Health and Medical Research Council Project Grant ID632877 The transcriptional control of adipogenesis M.Crossley and K. Bell-Anderson, 2010-12, $535,125
  • Australian Research Council Linkage Grant LP210200125 with industry partner CSL Limited Improving the efficiency of CRISPR gene editing in cells 2022-4 $412,919
  • Australian Research Council Discovery Projet DP220101489 Transcription factors find their target genes by reading the epigenetic code Kate Quinlan, Jacqui Matthews, and M. Crossley, 2021-3, $530, 579
  • Australian Research Council Discovery Project DP180103785 One code to rule them all: synthesis of the transcription factor and histone code J.P.Mackay, M. Crossley, K.K.J. Low and K.G.R. Quinlan, 2018-20, $598,198
  • Australian Research Council Discovery Project DP 170101786 Designer DNA-binding proteins M. Crossley and K. Quinlan, 2017-9, $428,000
  • Australian Research Council Discovery Project DP150103503 Role of methylation in transcription factor activity M. Crossley and J.P. Mackay, 2015-7, $428,100
  • Australian Research Council Discovery Project DP120103798 Functional analysis of a nucleic acid binding protein essential for mammalian development J.P. Mackay and M. Crossley, 2012-14, $458,000

Rhodes Scholarship 1987

Australian Society for Biochemistry and Molecular Biology Roche Medal 1999

Royal Society of NSW Sir Edgeworth David Medal 2000

Australian Academy of Science Gottschalk Medal 2002

Julian Wells Medal, Lorne Genome Conference 2010

Fellow Queen’s College, Melbourne 2014

Fellow Royal Society of New South Wales 2014

NSW Premier's Prize for Medical Biological Sciences 2020

Australia Society of Biochemistry and Molecular Biology Lemberg Medal 2021

Fundamental mechanisms of gene regulation with a view to using the information to treat human genetic diseases

My Research Supervision

Vala Nejad Safari

Mahdi Haddad

Michael O'Dea

Anthea On-Fai Lee

Sonia Goozee

Ramyashree Prasanna Kumar

Annalise Psaila

Henry Bell

Emily Vohralik